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  • Escamez, Sacha
    et al.
    Umeå University, Faculty of Science and Technology, Department of Plant Physiology. Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC).
    Tuominen, Hannele
    Umeå University, Faculty of Science and Technology, Department of Plant Physiology. Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC).
    Contribution of cellular autolysis to tissular functions during plant development2017In: Current opinion in plant biology, ISSN 1369-5266, E-ISSN 1879-0356, Vol. 35, 124-130 p.Article, review/survey (Refereed)
    Abstract [en]

    Plant development requires specific cells to be eliminated in a predictable and genetically regulated manner referred to as programmed cell death (PCD). However, the target cells do not merely die but they also undergo autolysis to degrade their cellular corpses. Recent progress in understanding developmental cell elimination suggests that distinct proteins execute PCD sensu stricto and autolysis. In addition, cell death alone and cell dismantlement can fulfill different functions. Hence, it appears biologically meaningful to distinguish between the modules of PCD and autolysis during plant development.

  • Ekbom, Ellen
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    "Alla kan ju berätta": - en kvalitativ studie om bibliotekariers arbete med barns muntliga berättande2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med den här uppsatsen är att undersöka bibliotekariers upplevelser av att arbeta med barns muntliga berättande. Metoden som används är kvalitativa intervjuer, där sammanlagt sex bibliotekarier intervjuas. I analysen presenteras resultatet från informanterna i tre olika delar, upplevelser och erfarenheter av barns muntliga berättande, arbetssätt som fungerat särskilt bra och särskilda utmaningar för att arbeta med barns muntliga berättande. Utöver detta går analysen även in på specifika områden som pedagogiska svårigheter, svåra ämnen, samarbeten och skillnader mellan äldre och yngre barn. Uppsatsen förankras kontinuerligt i tidigare forskning och i slutsatsen konstateras att bibliotekarierna är positiva till att arbeta med barns muntliga berättande, men att det inte görs i särskilt hög grad. De anser att det är något som är värdefullt för barnen av flera skäl, men upplever också att det finns svårigheter att genomföra detta arbete, trots att det är en uttalad uppgift för folkbiblioteken. Förhoppningsvis kan uppsatsen vara ett bidrag till att öka kunskapen i arbetet med barns muntliga berättande på biblioteken.

  • Public defence: 2017-05-12 09:00 E04_R1, Umeå
    Sandén, Per
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Efficacy and safety of warfarin treatment in venous thromboembolic disease2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]


    As a major cause of morbidity and mortality treatment of venous thromboembolism is important, with the correct use of anticoagulants it is possible to greatly reduce both mortality and morbidity. Warfarin is among the most widely used anticoagulants being effective in treatment and prevention of venous thromboembolism with few negative side effects other than bleeding complications. With a narrow therapeutic window warfarin treatment requires constant monitoring and adjustments to stay effective without an increased bleeding risk.

    The aim of this thesis was to study the efficacy and safety of warfarin treatment in venous thromboembolic disease.


    Using AuriculA, the Swedish national quality register for atrial fibrillation and anticoagulation, a cohort was created of patients registered with warfarin treatment during the study time January 1st 2006 to December 31th 2011, including all different indications for anticoagulation. In all four studies the study design was retrospective with information added to the cohort from the Swedish national patient register about background data and endpoints in form of bleeding complications in all studies and thromboembolic events in study 1 and 2. In study 3 and 4 information was added from the cause of death register about occurrence of death and in study 3 cause of death. In study 3, information from the prescribed drugs register about retrieved prescriptions of acetylsalicylic acid was added.


    In study 1 the mean TTR was found to be high both among patients managed at primary healthcare centres and specialised anticoagulation clinics at 79.6% and 75.7%. There was no significant difference in rate of bleeding between the two types of managing centres being 2.22 and 2.26 per 100 treatment years. In study 2 no reduction in complication rate with increasing centre TTR was seen for patients with atrial fibrillation with few centres having centre TTR below 70% (2.9%), in contrast to previous findings by Wan et al(1). For those with warfarin due to VTE where a larger proportion of the centres had centre TTR below 70% (9.1%) there was a reduction in complication rate with increasing centre TTR. Among the 13859 patients with treatment for VTE in study 3 age (HR 1.02, CI 95% 1.01-1.03), hypertension (HR 1.29, CI 95%1.02-1.64), Cardiac failure (HR 1.55, CI 95% 1.13-2.11), chronic obstructive pulmonary disease (HR 1.43, CI 95% 1.04- 1.96), alcohol abuse (HR 3.35, CI 95% 1.97-5.71), anaemia (HR 1.77, CI 95% 1.29-2.44) and a history of major bleeding (HR 1.75, CI 95% 1.27-2.42) increased the risk of bleeding during warfarin treatment. In study 4 both those with high iTTR and those with low INR variability had a low rate of bleedings at 1.27 (1.14-1.41) or 1.20 (0.94-1.21) per 100 treatment years compared to those with low iTTR and high INR variability having a rate of bleeding at 2.91 (2.61-3.21) or 2.61 (2.36-2.86) respectively. Those with the combination of both low iTTR and high INR variability had an increased risk of bleeding, hazard ratio HR 3.47 (CI 95 % 2.89-4.17). The quartile with both the lowest iTTR and the highest INR variability had an increased risk of bleeding with a hazard ratio 4.03 (3.20-5.08) and 3.80 (CI 95%, 3.01-4.79) compared to the quartile with the highest iTTR and lowest INR variability.


    It is possible to achieve a safe warfarin treatment both in specialised anticoagulation centres and in primary health care. At initiation of treatment some of the patients at high risk of bleeding can be identified using knowledge about their background. With the use of quality indicators as TTR and INR variability during treatment those at high risk of complications can be identified and analysing treatment quality on centre level gives an opportunity to identify improvement areas among managing centres. With the addition of new treatment options warfarin can still be the most suitable option for some patients, being safe and effective when well managed.

  • Public defence: 2017-05-12 13:15 Hörsal C, Lindellhallen, Umeå
    Walther, Daniel
    Umeå University, Faculty of Social Sciences, Department of Political Science.
    Till death do us part: a comparative study of government instability in 28 European democracies2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis is rooted in the research tradition known as coalition politics, where governments, political parties and political institutions are the central focus. The main emphasis here is on government instability and the question of why governments in modern parliamentary democracies often come to an end before the next regular election. In five distinct but interrelated papers, the thesis explores the issue of early government termination and how it is affected by public support, economic developments and the functioning of the state apparatus. The studies included in this thesis generally take a quantitative approach and make use of a dataset that contains 640 governments in 29 European democracies. Their joint goal is to improve our understanding of when early termination happens by introducing and testing new explanatory factors as well as by improving how previously identified factors are modelled.

    The first paper focuses on Central and Eastern Europe. It shows that the stability of governments in that region is affected by slightly different factors than those that impact on governments in Western Europe. In particular, ideological factors and political institutions are found to be less important in Central and Eastern Europe while the formal power basis of the government and the country’s economic performance matter more. In the second paper, co-authored with Professor Torbjörn Bergman, the state is brought into government stability research. The paper shows that countries with a lower quality of governance and a less efficient public sector have less stable governments. This is mainly because government parties struggle to achieve their policy goals when the state apparatus is inefficient and corrupt.

    Paper 3, co-written with Associate Professor Johan Hellström, looks at how different types of governments respond to economic challenges. In particular, this paper demonstrates that the same changes in economic circumstances (e.g. increases in unemployment or inflation) have different effects on cabinet stability depending on which type of government is in charge. Single party governments are better equipped to deal with economic changes, because they are better positioned to devise new policy responses without having to compromise with other parties. Coalition governments, in contrast, become significantly more likely to terminate early when the economy takes a turn for the worse.

    Finally, over the course of two papers I first explore new techniques for analysing polling data and then use them to empirically test whether governments sometimes choose termination as a way to cope with bad poll numbers. Most of the existing techniques for pooling polls and forecasting elections were explicitly designed with two party systems in mind. In Paper 4, I test some of these techniques to determine their usefulness in complex, multiparty systems, and I develop some improvements that enable us to take advantage of more of the information in the data. In the final paper, I combine the two themes of polling and government stability by looking at how changes in government popularity affect the likelihood of premature dissolution. I find that governments, particularly single party governments, do, in fact, use terminations as a strategic response to changes in their popularity among the public. When support is high, governments tend to opportunistically call an early election, whereas they tend to abandon or reshuffle the government when support is low.

  • Public defence: 2017-05-12 09:00 KB.E3.01 Lilla Hörsalen, Umeå
    Jonna, Venkateswara Rao
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Class I Ribonucleotide Reductases: overall activity regulation, oligomerization, and drug targeting2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Ribonucleotide reductase (RNR) is a key enzyme in the de novo biosynthesis and homeostatic maintenance of all four DNA building blocks by being able to make deoxyribonucleotides from the corresponding ribonucleotides. It is important for the cell to control the production of a balanced supply of the dNTPs to minimize misincorporations in DNA. Because RNR is the rate-limiting enzyme in DNA synthesis, it is an important target for antimicrobial and antiproliferative molecules. The enzyme RNR has one of the most sophisticated allosteric regulations known in Nature with four allosteric effectors (ATP, dATP, dGTP, and dTTP) and two allosteric sites. One of the sites (s-site) controls the substrate specificity of the enzyme, whereas the other one (a-site) regulates the overall activity.  The a-site binds either dATP, which inhibits the enzyme or ATP that activates the enzyme. In eukaryotes, ATP activation is directly through the a-site and in E. coli it is a cross-talk effect between the a and s-sites. It is important to study and get more knowledge about the overall activity regulation of RNR, both because it has an important physiological function, but also because it may provide important clues to the design of antibacterial and antiproliferative drugs, which can target RNR.

    Previous studies of class I RNRs, the class found in nearly all eukaryotes and many prokaryotes have revealed that the overall activity regulation is dependent on the formation of oligomeric complexes. The class I RNR consists of two subunits, a large α subunit, and a small β subunit. The oligomeric complexes vary between different species with the mammalian and yeast enzymes cycle between structurally different active and inactive α6β2 complexes, and the E. coli enzyme cycles between active α2β2 and inactive α4β4 complexes. Because RNR equilibrates between many different oligomeric forms that are not resolved by most conventional methods, we have used a technique termed gas-phase electrophoretic macromolecule analysis (GEMMA). In the present studies, our focus is on characterizing both prokaryotic and mammalian class I RNRs. In one of our projects, we have studied the class I RNR from Pseudomonas aeruginosa and found that it represents a novel mechanism of overall activity allosteric regulation, which is different from the two known overall activity allosteric regulation found in E. coli and eukaryotic RNRs, respectively.  The structural differences between the bacterial and the eukaryote class I RNRs are interesting from a drug developmental viewpoint because they open up the possibility of finding inhibitors that selectively target the pathogens. The biochemical data that we have published in the above project was later supported by crystal structure and solution X-ray scattering data that we published together with Derek T. Logan`s research group.

    We have also studied the effect of a novel antiproliferative molecule, NSC73735, on the oligomerization of the human RNR large subunit. This collaborative research results showed that the molecule NSC73735 is the first reported non-nucleoside molecule which alters the oligomerization to inhibit human RNR and the molecule disrupts the cell cycle distribution in human leukemia cells.

  • Public defence: 2017-05-12 10:15 Hörsal B, Samhällsvetarhuset, Umeå
    Brännström, Malin
    Umeå University, Faculty of Social Sciences, Department of Law.
    Skogsbruk och renskötsel på samma mark: En rättsvetenskaplig studie av äganderätten och renskötselrätten2017Doctoral thesis, monograph (Other academic)
    Abstract [en]

    In the northern parts of Sweden forestry and Sami reindeer herding are exercised on the same land and there is an ongoing land use dispute between the land users. Land ownership and reindeer herding rights, based on immemorial prescription and customary law, are parallel property rights to the same land. Studies have concluded that the legal framework does not sufficiently reflect the property rights perspective of the land use conflict. This study examines the legal framework that regulates the relationship between forestry and reindeer herding from a property rights perspective. Starting points of the study are basic aspects of property rights, such as the right to use, decide on and benefit economically from property and the legal protection required in relation to others. Comparisons are made with the legal frameworks that regulate other relationships within real estate law, including e.g. neighbors, easements, joint facilities and utility easement.

    The study concludes that the relationship between land ownership and reindeer herding rights can be understood only against the background of historical events such as colonization and demarcation. The rights are more independent of each other than other legal relations and can be compared to a double ownership. It is further concluded that the Forestry Act is based on the assumption that reindeer herding is primarily a public interest that needs protection. Land owners have a far-reaching right to use forests that causes damages to reindeer pasture lands that is not in accordance with the legal nature of the reindeer herding right. Further, central elements usually used to regulate property rights relations are missing, e.g. mutual consideration, damages and judicial review.

    The study also examines if the legal framework is in accordance with the constitutional protection of property in Chapter 2 Section 15 of the constitutional Instrument of Government and Article 1 of the First Protocol to the European Convention on Human Rights. It is concluded that the legal framework has several deficiencies in this respect. Elements are discussed that can be implemented in law to appropriately reflect the property rights studied.

  • Pettersson, Mona
    Umeå University, Faculty of Social Sciences, Department of Informatics.
    Microchip implants and you: A study of the public perceptions of microchip implants2017Independent thesis Advanced level (degree of Master (Two Years)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    As technology advances with time, new devices are invented and old ones used in innovative ways. Microchips have been increasingly minimized to the point where they can now fit on a fingernail. When encased in a bio-friendly coating and equipped with the appropriate in- or output technology, new modes of natural digital interaction can be explored. This thesis studies how the general public perceives microchip implants as a digital interaction tool, as well as which features of microchip implants are important to them. Three different scenarios of implanted microchip use were created and used in eight semi-structured interviews. The results showed skepticism towards the technology due to worries about security and privacy, and a lack of knowledge of this technology. Benefits included keeping better track of health and making everyday actions easier, as well as excitement about this new technology. 

  • Ku, Dennis
    Umeå University, Faculty of Social Sciences, Department of Informatics.
    Take a Paws: Using cute media to alleviate computer frustration2017Independent thesis Advanced level (degree of Master (Two Years)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Computers have become an indispensable resource in assisting us in our daily life. While they do a good job most of the time, sometimes they can create a seemingly endless nightmare. Horrible user interfaces, bugs, errors, hardware issues and other factors are various causes of user frustration. The current approach is to either prevent it from happening or to fix the issue after it has appeared. In this study, an alternative approach is explored which makes use of distraction through mood induction. By using cute images of infantile animals it was argued that this could alleviate computer frustration. For this study, 60 participants were used to test this theory by first doing a frustrating task and a consequent treatment or control exposure. Mood and frustration levels were collected throughout the test and later analyzed. Additionally, opinions and reactions were collected using a follow-up interview and observations. Findings suggest that looking at cute images helps alleviate frustration caused by computers.

  • Nygren, Erik
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies.
    Kampen för religionsfrihet: Förbundet för religionsfrihet 1952-19682016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Tanentzap, Andrew J.
    et al.
    Kielstra, Brian W.
    Wilkinson, Grace M.
    Berggren, Martin
    Craig, Nicola
    del Giorgio, Paul A.
    Grey, Jonathan
    Gunn, John M.
    Jones, Stuart E.
    Karlsson, Jan
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Solomon, Christopher T.
    Pace, Michael L.
    Terrestrial support of lake food webs: Synthesis reveals controls over cross-ecosystem resource use2017In: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 3, no 3, e1601765Article in journal (Refereed)
    Abstract [en]

    Widespread evidence that organic matter exported from terrestrial into aquatic ecosystems supports recipient food webs remains controversial. A pressing question is not only whether high terrestrial support is possible but also what the general conditions are under which it arises. We assemble the largest data set, to date, of the isotopic composition (delta H-2, delta C-13, and delta N-15) of lake zooplankton and the resources at the base of their associated food webs. In total, our data set spans 559 observations across 147 lakes from the boreal to subtropics. By predicting terrestrial resource support from within-lake and catchment-level characteristics, we found that half of all consumer observations that is, the median were composed of at least 42% terrestrially derived material. In general, terrestrial support of zooplankton was greatest in lakes with large physical and hydrological connections to catchments that were rich in aboveground and belowground organic matter. However, some consumers responded less strongly to terrestrial resources where within-lake production was elevated. Our study shows that multiple mechanisms drive widespread cross-ecosystem support of aquatic consumers across Northern Hemisphere lakes and suggests that changes in terrestrial landscapes will influence ecosystem processes well beyond their boundaries.

  • Lindh, Markus V.
    et al.
    Sjostedt, Johanna
    Ekstam, Borje
    Casini, Michele
    Lundin, Daniel
    Hugerth, Luisa W.
    Hu, Yue O. O.
    Andersson, Anders F.
    Andersson, Agneta
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Legrand, Catherine
    Pinhassi, Jarone
    Metapopulation theory identifies biogeographical patterns among core and satellite marine bacteria scaling from tens to thousands of kilometers2017In: Environmental Microbiology, ISSN 1462-2912, E-ISSN 1462-2920, Vol. 19, no 3, 1222-1236 p.Article in journal (Refereed)
    Abstract [en]

    Metapopulation theory developed in terrestrial ecology provides applicable frameworks for interpreting the role of local and regional processes in shaping species distribution patterns. Yet, empirical testing of metapopulation models on microbial communities is essentially lacking. We determined regional bacterioplankton dynamics from monthly transect sampling in the Baltic Sea Proper using 16S rRNA gene sequencing. A strong positive trend was found between local relative abundance and occupancy of populations. Notably, the occupancy-frequency distributions were significantly bimodal with a satellite mode of rare endemic populations and a core mode of abundant cosmopolitan populations (e.g. Synechococcus, SAR11 and SAR86 clade members). Temporal changes in population distributions supported several theoretical frameworks. Still, bimodality was found among bacterioplankton communities across the entire Baltic Sea, and was also frequent in globally distributed datasets. Datasets spanning waters with widely different physicochemical characteristics or environmental gradients typically lacked significant bimodal patterns. When such datasets were divided into subsets with coherent environmental conditions, bimodal patterns emerged, highlighting the importance of positive feedbacks between local abundance and occupancy within specific biomes. Thus, metapopulation theory applied to microbial biogeography can provide novel insights into the mechanisms governing shifts in biodiversity resulting from natural or anthropogenically induced changes in the environment.

  • Fulton, Joel
    et al.
    Mazumder, Bismoy
    Whitchurch, Jonathan B.
    Monteiro, Cintia J.
    Collins, Hilary M.
    Chan, Chun M.
    Clemente, Maria P.
    Hernandez-Quiles, Miguel
    Stewart, Elizabeth A.
    Amoaku, Winfried M.
    Moran, Paula M.
    Mongan, Nigel P.
    Persson, Jenny L.
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Division of Experimental Cancer Research, Department of Translational Medicine, Lund University, Clinical Research Centre, Malmö, Sweden.
    Ali, Simak
    Heery, David M.
    Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-gamma (PPAR gamma) are disrupted by retinal disease-associated mutations2017In: Cell Death and Disease, ISSN 2041-4889, E-ISSN 2041-4889, Vol. 8, e2677Article in journal (Refereed)
    Abstract [en]

    Photoreceptor-specific nuclear receptor (PNR/NR2E3) and Tailless homolog (TLX/NR2E1) are human orthologs of the NR2E group, a subgroup of phylogenetically related members of the nuclear receptor (NR) superfamily of transcription factors. We assessed the ability of these NRs to form heterodimers with other members of the human NRs representing all major subgroups. The TLX ligand-binding domain (LBD) did not appear to form homodimers or interact directly with any other NR tested. The PNR LBD was able to form homodimers, but also exhibited robust interactions with the LBDs of peroxisome proliferator-activated receptor-gamma (PPAR gamma)/NR1C3 and thyroid hormone receptor b (TRb) TR beta/NR1A2. The binding of PNR to PPAR. was specific for this paralog, as no interaction was observed with the LBDs of PPAR alpha/NR1C1 or PPAR delta/NR1C2. In support of these findings, PPAR. and PNR were found to be co-expressed in human retinal tissue extracts and could be co-immunoprecipitated as a native complex. Selected sequence variants in the PNR LBD associated with human retinopathies, or a mutation in the dimerization region of PPAR. LBD associated with familial partial lipodystrophy type 3, were found to disrupt PNR/PPAR gamma complex formation. Wild-type PNR, but not a PNR309G mutant, was able to repress PPAR gamma-mediated transcription in reporter assays. In summary, our results reveal novel heterodimer interactions in the NR superfamily, suggesting previously unknown functional interactions of PNR with PPAR. and TR beta that have potential importance in retinal development and disease.

  • Hellström, Anna
    Umeå University, Faculty of Social Sciences, Department of Education.
    Extra anpassningar: Har det påverkat pedagogernas sätt att arbeta?2016Independent thesis Basic level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Syftet med studien var att beskriva och analysera ett antal pedagogers uppfattningar av begreppet extra anpassningar, hur de arbetar med extra anpassningar, samt hur det har påverkat deras arbete med att stödja elever i svårigheter på ett antal grundskolor i en mindre kommun i södra Norrland. Forskningsfrågorna lyder: Hur identifieras elevernas behov av stödinsatser? Hur tolkas begreppet extra anpassningar av pedagogerna? Hur arbetar pedagogerna kring extra anpassningar och hur följs insatserna upp? Den metod som använts i studien är kvalitativa intervjuer som genomfördes med nio klasslärare och tre specialpedagoger på fyra olika grundskolor i den valda kommunen. Resultatet visade att alla intervjuade pedagoger var medvetna om begreppet extra anpassningar, men uttrycker en osäkerhet i skillnaden mellan de olika begreppen extra anpassningar och särskilt stöd som förekommer i de allmänna råden. Dock framkommer att klasslärarna ger uttryck för att det är något de alltid har gjort, men inte uppmärksammat på det sätt som Skolverket (2014a) belyser i de allmänna råden. Studien visar att om lärare ska kunna inkludera alla elever med hjälp av stödinsatser såsom extra anpassningar, är det viktigt, att de får stöd i det arbetet, både från ledning och med stöd av resultat från forskning i det specialpedagogiska fältet i form av ökade kunskaper och verktyg som kan användas i undervisningen, samt att rutiner fastställs för hur detta arbete ska genomföras.

  • Rehnman, Bernice
    Umeå University, Faculty of Social Sciences, Department of Education.
    Kämpa eller ge upp?: En studie om attityder till lärande hos gymnasieelever som får stödinsatser2016Independent thesis Basic level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Myhr, Madeleine
    Umeå University, Faculty of Arts, Department of culture and media studies.
    "Hvis du undrer så har jeg endret språket på telefonen!": En netnografisk studie om Skams fandom på Facebook2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study aims to examine how Swedish fans of the TV-series Skam use the Facebook group Kosegruppa Sverige in order to construct and maintain a fandom, and how fan practices can contribute in creating identity among the members of the group. Theories related to fan research, discourse psychology and intersectionality were applied, as well as a brief overview of earlier research results related to these areas. By using a netnographic approach combined with a discourse analyses, posts made by fans on Kosegruppa Sverige during December 2016 were examined and analyzed.

    Three main fan practices were found to be used in constructing fandom in the group; fans made their own material such as edits, videos and attire that had a connection to the narrative, they acted out on their fandom both by adapting their language and looks, and finally by buying and selling merchandise and thus collecting things related to the series. Identity was created through intersectional perspectives of gender, sexuality and age. Finally, the study concluded that fandom could be seen as an integral tool within media production, which blurs the line between producers and consumers. 

  • Farrokhi, Anna
    Umeå University, Faculty of Social Sciences, Department of Education.
    Barn i kris: Specialpedagogers tankar om bemötande av och arbete med barn i kris2017Independent thesis Basic level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Syftet med denna studie är att utvinna kunskap ur åtta specialpedagogers berättelser om deras arbete med barn i kris. Studien bygger på en kvalitativ metod genom semistrukturerade intervjuer och en tematisk innehållsanalys. Bakgrunden presenterar en genomgång av lagar och styrdokument som påverkar arbetet med barn i kris, tidigare forskning om arbete med barn i kris samt en genomgång av specialpedagogiska perspektiven som utgör studiens teoretiska grund. Resultatet uppvisar att arbete med barn i kris i skolan är krävande och bygger på en organisation som sluter upp kring barnet. Det stöd som behövs ska ges genom anpassning av lärmiljön, till personen som jobbar närmast barnet och från de professionella i elevhälsan för att kunna skapa en gynnsam miljö för en optimal återhämtningsprocess. Resultatet visar även på brister inom de organisatoriska förutsättningarna för att kunna arbeta optimalt med barn i kris. Resursbristerna pekas ut som de största orsakerna till svårigheterna. I resultatanalysen åskådliggörs att specialpedagogernas tankar kring arbetet med barn i kris följer tidigare forskning, lagar och styrdokumentens skrivelser. Det tydliggörs även att specialpedagogerna över lag har svårigheter att genomföra de optimala åtgärderna trots de kunskaper de besitter. Avslutningsvis diskuteras slutsatserna av studien, där det framgår att barn i kris och barn i dolda kriser löper en stor risk att få ökad psykisk ohälsa. Slutsatser som dras är att proaktivt arbete behöver aktualiseras i skolans grundläggande arbete, där framförallt barns mående, relationer och grupprocesser måste vara i fokus.

  • Brännvall, Maria-Sofia Kristina
    et al.
    Umeå University, Faculty of Social Sciences, Department of Education.
    Morin Johansson, Susanne
    Umeå University, Faculty of Social Sciences, Department of Education.
    Är specialpedagogen på väg att reformeras bort?: Skolpolitiska reformers potentiella inverkan på specialpedagogprofessionen.2017Independent thesis Basic level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    I föreliggande uppsats ville vi fokusera på den styrning vi i dag ser och hur den i olika grad påverkar specialpedagogens yrkesroll. Diskussionen om lärarna som professionella har betonats i takt med att styrningen av skolan har förändradrats och decentraliserats till att bli den mål- och resultatstyrda skola vi har i dag med ett kommunalt huvudmannaskap. Syftet formulerades som så att beskriva och analysera ett antal skolpolitiska reformer och deras potentiella inverkan på specialpedagogprofessionen. Vi utgick ifrån professionsteori som ett teoretiskt ramverk som hjälpte oss att expandera förståelsen för studiens resultat. Med hjälp av styrdokument, forskning inom området samt intervjuer med specialpedagoger skulle studien besvara följande frågeställningar. Vad har specialpedagoger för tankar, erfarenheter och idéer gällande sin profession? Vad har specialpedagoger för tankar, erfarenheter och idéer om professionen i förhållande till de senaste reformerna på området? Vilka faktorer påverkar specialpedagogens profession? Specialpedagogerna i studien har alla ett specialpedagogiskt perspektiv där de ser på skolan utifrån tre olika nivåer; organisation-, grupp- och individ. Vi fann att ändringarna i lagen gällande extra anpassningar och särskilt stöd samt förstelärarreformen har inverkat på professionen och i och med delvis detta kom vi fram till fem faktorer som påverkar specialpedagogprofessionen. Forskning om och utvärdering av implementering av reformer och utfallet av dem kan vara ett sätt att förhoppningsvis stärka professionerna i vårt ovanifrån styrda utbildningsväsende.

  • Spruyt, Jon
    Umeå University, Faculty of Social Sciences, Department of Informatics.
    Gamified Individual Brainstorming: Reaching for the stars2017Independent thesis Advanced level (degree of Master (Two Years)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Ideation is a critical step in the creation of new solutions to problems. Brainstorming, being the most commonly known ideation method, is mostly done in groups. However, research points out that brainstorming individually is more effective than brainstorming in groups. This paper investigates if negative aspects (reduced enjoyment, motivation and self-rated performance) associated with brainstorming alone can be overcome by using a gamified approach to brainstorming. Gamified and non-gamified prototypes have been made and used in combination with a questionnaire to measure differences in these negative aspects. From the within-subject study including 20 participants, it appears that the implemented gamification approach was not different from the non-gamified approach for most of the negative aspects. Self-rated performance was however significantly higher in the non-gamified version. Using the gamified or non-gamified approach seems to largely come down to the preference of the user.

  • Hulo, Fatma
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
    Jämförelse av effektivitet och säkerhet vid oral eller intravenös järnsubstitution för behandling av järnbristanemi under graviditet2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Karlström, Malin
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
    Ankyloserande Spondylit och tumörnekrosfaktor-α-hämmare: En jämförelse av effekt och säkerhet vid behandling hos patienter med ankyloserande spondylit2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Tanghöj, Gustaf
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics. Unit of Research Education and Development, Östersund Hospital, Östersund, Sweden.
    Odermarsky, Michal
    Naumburg, Estelle
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics. Unit of Research Education and Development, Östersund Hospital, Östersund, Sweden.
    Liuba, Petru
    Early Complications After Percutaneous Closure of Atrial Septal Defect in Infants with Procedural Weight Less than 15 kg2017In: Pediatric Cardiology, ISSN 0172-0643, E-ISSN 1432-1971, Vol. 38, no 2, 255-263 p.Article in journal (Refereed)
    Abstract [en]

    Atrial septal defect (ASD) is the most common congenital cardiac lesion accounting for 10-15% of all cardiac malformations. In the majority of cases, the secundum type of the ASD is closed percutaneously in the catheterization laboratory. Although transcatheter closure of ASD is considered safe and effective in pediatric patients, there are limited data regarding the efficacy and safety of device ASD closure in smaller infants. The aim of this study was to determine risk of complications within 72 h following device closure of ASD in children of body weight < 15 kg compared to larger children. Overall 252 children who underwent transcatheter closure of ASD at Children's Heart Centre in Lund, Sweden, between 1998 and 2015 were included. Data regarding demographics, comorbidity and complications occurring during and after device procedure until discharge were retrieved from the hospital's databases. Echocardiographic data were obtained from the digital and videotape recordings. Nearly half of the study cohort (n = 112; 44%) had a procedural weight < 15 (median 11.3) kg with a median procedural age of 2.02 years. Among this study group, 22 (9%) children had post-procedural in-hospital complications, of which 16 (7%) were considered as major and six (2%) considered as minor. No deaths occurred. There was no significant difference in of the occurrence of major or minor complications between the two groups (p = 0.32). Larger ASD was more often associated with minor complications, OR 1.37 (95% CI 0.99-1.89), which most often consisted of transient arrhythmias during or after the procedure. Percutaneous ASD device closure can be performed safely in low-weight infants with a risk of post-procedural in-hospital complications comparable to larger/older children. Nevertheless, careful considerations of the indications to device closure is needed, particularly in children with larger ASD, as recommended by the current international guidelines for ASD closure.

  • Seekell, David
    et al.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Carr, Joel
    Dell'Angelo, Jampel
    D'Odorico, Paolo
    Fader, Marianela
    Gephart, Jessica
    Kummu, Matti
    Magliocca, Nicholas
    Porkka, Miina
    Puma, Michael
    Ratajczak, Zak
    Rulli, Maria Cristina
    Suweis, Samir
    Tavoni, Alessandro
    Resilience in the global food system2017In: Environmental Research Letters, ISSN 1748-9326, E-ISSN 1748-9326, Vol. 12, no 2, 025010Article in journal (Refereed)
    Abstract [en]

    Ensuring food security requires food production and distribution systems function throughout disruptions. Understanding the factors that contribute to the global food system's ability to respond and adapt to such disruptions (i.e. resilience) is critical for understanding the long-term sustainability of human populations. Variable impacts of production shocks on food supply between countries indicate a need for national-scale resilience indicators that can provide global comparisons. However, methods for tracking changes in resilience have had limited application to food systems. We developed an indicator-based analysis of food systems resilience for the years 1992-2011. Our approach is based on three dimensions of resilience: socio-economic access to food in terms of income of the poorest quintile relative to food prices, biophysical capacity to intensify or extensify food production, and the magnitude and diversity of current domestic food production. The socio-economic indicator has a large variability, but with low values concentrated in Africa and Asia. The biophysical capacity indicator is highest in Africa and Eastern Europe, in part because of a high potential for extensification of cropland and for yield gap closure in cultivated areas. However, the biophysical capacity indicator has declined globally in recent years. The production diversity indicator has increased slightly, with a relatively even geographic distribution. Few countries had exclusively high or low values for all indicators. Collectively, these results are the basis for global comparisons of resilience between countries, and provide necessary context for developing generalizations about resilience in the global food system.

  • Forssell, Linnéa
    et al.
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Sjöström, Elin
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Inte en vanlig eljätte men lite mer inlindat i bomull: En receptionsanalys av Skellefteå Krafts externa kommunikation av CSR och hållbar utveckling samt hur studenter avkodar budskapet.2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    A reception analysis on Skellefteå Krafts external communication on CSR and sustainable development and in what ways students decode the message.

    As an effect of today's climate changes and global issues, one of the most important subjects for companies to communicate to consumers and stakeholders is corporate social responsibility (CSR). The purpose of this paper is to investigate in what ways the concept of responsibility in relation to corporate social responsibility and sustainable development infuse meaning in the external communication by the company Skellefteå Kraft. The paper also examines the way three respondent groups of students relate to this message.

    The theoretical frame stretches from different views on CSR- communication to green brand strategy and sustainable development. The critic on CSR-communication includes the concept of greenwashing. The study also relies on theories within semiotic analysis, reception analysis and Stuart Halls encoding decoding model. Using the method visual semiotic analysis made it possible to reveal what Stuart Hall calls the preferred reading of the company's external communication. To be able to analyze the way students relate to the message qualitative interviews was used. Tools within reception analyze was applied on the material from the interviews.

    Both the visual semiotic analysis and the analyze of the interviews showed that the external communication did not include the economic side of CSR as much as the social- and environmental aspect. This was to be expected since the campaigns are focused on customers and other stakeholders. The main result was that the respondents in large made a hegemonic read of both the advertising films and the campaign site. They lay focus primarily on the caption and less on the image itself. The respondents could mainly distinguish the communication of social responsibility. This may be because both campaigns focus primarily on the human being and different life styles. When it comes to environmental responsibility the analysis show that Skellefteå Kraft uses ecological arguments in their external communication about energy and electrician, but they do not demonstrate the extraction which does in fact have some negative effects on nature. If Skellefteå Kraft had been more willing to demonstrate the extraction process they probably would have been described as honest and their ecological arguments would have been more comprehensible. This would also be proof that the company has little to hide when it comes to environmental

    responsibility. The advertising film as well as the campaign site communicates joyfulness and naturally produced electricity.

  • Sonevik, Linnéa
    et al.
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Wahlgren, Agnes
    Umeå University, Faculty of Arts, Department of culture and media studies.
    ”I’ve never been politically correct – truthfully it takes far too much time and can often make it more difficult to achieve total victory”: En kritisk diskursanalys av Donald Trumps tal under valåret 20162017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study, ​“‘I’ve never been politically correct – truthfully it takes far too much time and can often make it more difficult to achieve total victory’ - a Critical Discourse Analysis of Donald Trump's speeches during United States presidential election of 2016”​, examines the political communication through linguistic strategies throughout 10 of Donald Trump’s speeches from the Trump rallies during the election year 2016. In order to serve that purpose, this thesis investigates which ones of the discourses that dominates the republican agenda in this context. ​Accordingly to the Critical Discourse Analysis the aim is also to see whether the worldview in Trumps speeches is constructed or deconstructed.

    The study is based on a theoretical framework with theories about social constructionism, nationalism and populism. A quantitative content analysis was made through the online text tool “Textometrica” in order to see Trumps main discourses. The qualitative content analysis was made through Norman Faircloughs three-dimensional model for a Critical Discourse Analysis.

    According to the analysis of this study, the five main discourses are ​Establishment, Trump, USA, Immigration ​and​ Work​. Around these discourses, Donald Trump’s main strategy is constructing an opposition between “us” and “them”, where “us” consist with Trump himself and the american people, and “them” includes the establishment, other countries and immigrants. Based on these opponents, and through disparaging “them” in a strategy, here called “the thief-strategy”, Trump constructs a reality where “us” is the better half and he appears as the hero in this duo.

    In conclusion, Trumps strategy in order to win the presidential election 2016 included running a political agenda characterized by populism which later on can lead to a polarized community, and a dissatisfied american people who will be open for change and a new leader.

  • Pettersson, Felix
    Umeå University, Faculty of Arts, Department of culture and media studies.
    ”Det handlar om mentala faktorer”: En studie i hur vinnarmentalitet gestaltas i svensk sportpress2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Title: ”It’s about mental factors” – Examining how a “winner’s mentality” is portrayed in Swedish sports mediaThis essay aims to explore what the Swedish sports media means when it discusses the term of a “winner’s mentality”, through a discourse analysis. More specifically this essay studies how the language in nine different sports papers in Sweden construes the meaning of the word by combining it with different signs and through the use of metaphors, a commonly used linguistic trick in Sportugese. The articles selected for analysis were all published in a one month span between the 8th of December 2016 and the 8th of January 2017. This particular period of time was selected because it included the 2017 World Juniors in ice hockey, a tournament in which the Swedes have placed fourth three years in a row, and which sparked a debate in the Swedish sports press about the team’s “winner’s mentality”.The study found five major themes within the sports journalistic discourse. A major aspect was focusing on the athlete´s psychology, their self-confidence and their will to win. This closely resembles the discourse in popular psychology, more specifically self-help texts where the readers are encouraged to change through active will. Another major theme was that of a winning record. According to the sports press, if an athlete or a team wins more often than not than that proves they possess a “winner’s mentality” and helps them win in the future as well. The essay also found differences in “winner´s mentality” based on a cultural aspect. Swede’s ability to win was downplayed while Americans were praised for their unusually strong mental abilities. This is also found in Swedish self-help texts and might indicate a much larger discourse in national identity at work. The two last themes identified were the importance of experience, and also that a “winner´s mentality” could be affected by a large amount of external factors.Overall the study found that the discourse was in disagreement within itself. A “winner´s mentality” could mean plenty of different things, and in some cases actively opposes itself. Another finding was that the sports press rarely reflects on the meaning of the term and instead mostly uses it as a rhetoric weapon or to make a point across. This raises the question whether or not the term has an actual use within sports terminology and debate if it can be interpreted in many different ways.

  • Söderqvist, Marlene
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Lyckodiskurser i en senmodern verklighet: En kvantitativ innehållsanalys och kritisk diskursanalys av porträtteringen av lyckliga människor i kvällspress under 20152016Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    We are today living in a society with endless possibilities. A society where you can dream about something more. What makes you happy is important to study, though it’s a big part of people’s life quality. It’s important to consider how media chooses to portray it, because it affects how the society judges and adapts to the message media is sending out. The purpose of this essay is to consider how happiness is constructed in evening papers and how it differs between different gender portrayals.

    The methods that were used were a quantitative content analysis and a critical discourse analysis founded by Norman Fairclough. The material was mainly taken from Swedish evening papers Aftonbladet and Expressen. A total of 203 articles were analyzed, and a total of 19 articles were more closely analyzed with a critical discourse analysis.

    Theories that were used in the analysis were theories about happiness, gender, framing and stereotypes, as well as earlier research on the subject concerning portraits and gender.The result shows that there are different subjects that are being connected to happiness, but being in a happy relationship and having a well receiving job are the most popular ones. Most the portrayed people are famous in some way. There are several differences between male and female portrayals and the most vital ones are a central focus on men’s work life, and for women there are more focus on children, looks and praise for managing to fight her way through life.

  • Lif, Stina
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Bland hyckleri och hemohes: En textanalytisk studie av den svenska rapporteringen om finska och ryska dopningsfall2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The aim of this study has been to, through a quantitative content analysis and a qualitative

    text analysis, determine which meaning nationality is given in news reports in Swedish daily

    press, and how it creates the event as a scandal. Focusing on two major scandals in cross

    country skiing, articles from the Finnish scandal in Lahtis 2001 and the revealing of doped

    Russian skiers in 2016 has been analysed. The theoretical framework for the study has been

    Stuart Halls representation theory, the framing theory, and theories regarding media scandals

    and nationality. The results from the quantitative and qualitative analyses has been divided

    into four themes: Imagined communities, Us and them, Individual and corporate and Fallen

    star. The results show that nationality is given meaning through the creation of imagined

    communities. It creates a gap between us and them, a sense of the nations parting from each

    other in form of cultural and moral aspects. There is also a difference between the

    representation of the countries. In the Russian doping scandal, Russia is considered as a doped

    nation, with a systematic doping where little guilt is to be put on the skiers themselves. In

    Finland, the nation stands for the people and is not in any ways to be associated with the

    doping scandal. Instead, the skiers get all the blame and little notion is made about the doping

    as being organised. This has also made the scandals to be divided into individual or corporate

    doping. As for the framing of the event as a scandal, attributes as “cheating” and a portrayal

    of the skiers as fallen stars is represented. By revealing the names of the suspected dopers it

    increases the news worth. An unexpected outcome was that the Russian dopers was not

    mentioned by name as often as the Finnish, which could enhance the event as a scandal even

    more. Furthermore, doping scandals could be studied in many different ways and is an

    interesting subject to immerse oneself in.

  • Källman, Marie
    et al.
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Fellman, Elin
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Kvinnor i olympiaden. En jämförande studie av kvinnors representation och framställning i media under OS-åren 1996 och 20162017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]


    Women in the olympics - A quantitative and qualitative analysis of the representation and portayal of female athletes in the olympics

    The purpose of the study was to examine how often female athletes occur in swedish sports media and how they are portrayed, in comparison to male athletes. The years studied was 1996 and 2016. Since the female participants increased over those twenty years it was interesting to see if the media followed that development. The study is based on earlier research such as Natalie Koivula and her concepts of the trivialization, infantilization and ambivalens of female athletes. Some theories used in the study is agenda setting, discourse analysis and different gender theories by, among others, Hirdman, Butler and Conell & Pearse.

    A quantitative and a qualitative analysis has been used in order to determine the representation and portrayal of female athletes. Over 400 articles about the olympics from the newspapers Aftonbladet and Expressen was coded using a content analysis to identify how often female athletes occur in comparison to men. For the discourse analysis 12 articles, three from every newspaper and year was coded using both theories and earlier research.

    The result shows that there was a difference in both representation and portrayal between men and women in 1996, with men overrepresented in both team sports and individual sports. In 2016 there the results show a complete reversal with women overrepresented in all sports. There was a clear difference in the portrayal of female and male athletes in 1996, where womens looks were described more often than their sporting efforts. In 2016 however the portrayal of women were more similar to men, with a few exceptions.

    The results of the study from 1996 can be explained by the patriarchal structures that our society is built on. Although the patriarchy still is present it is clear to see that feminism and gender issues have affected the society over the last twenty years, giving female athletes a better chance to be represented and portrayed equally to male athletes.

  • Jernstig, Embla
    et al.
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Wikström, Mikaela
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Hur viktig är vikten?: En kvantitativ och kvalitativ studie av Expressen och Aftonbladets framställning av vikt, utseende och hälsa.2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In media we often see articles about how to lose weight, what we shouldn’t like about our bodies and how to get rid of these so called problems. In this essay we examine how weight is portrayed in Sweden’s two largest evening papers, Expressen and Aftonbladet. The purpose of the essay is to see how Swedish evening papers portray weight in relation to health, appearance, and diet. We have used a quantitative content analysis combined with a qualitative critical discourse analysis to examine this. The two methods combined strengthen the validity and reliability in our results. We examine articles from the newspapers from the years of 1996, 2006 and 2016 to be able to see the differences between these years. Through the quantitative content analysis, we found many interesting patterns. Some of the most important findings are that weight often is portrayed in a way of change and not as something static. A loss of weight is in a majority of the articles described as something positive, whereas to gain weight is described as a problem and something negative. We have also found interesting results about gender. Women take the roll of a private person in a majority of the cases. The role of the expert in the articles have changed from a majority of men to a majority of women. Dieting is portrayed as something typically feminine. In the discourse of weight there seems to be at strong connection between the skinny body, happiness and health whereas the fat body is submissively connected to sickness and ill-health. Our bodies seem to be looked at like a project to be taken care of, in order to fit in to the bodily-norms. If someone fits in to the norm they get values in life in return. Our conclusion is that stereotypical norms of the skinny body and the good in loss of weight is reproduced in Expressen and Aftonbladet, and that this haven’t changed over time. We argue that this can lead to consequences in peoples lifes and a discrimination to certain groups in the society.

  • Hansson Vikström, Greta
    et al.
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Hedlund, Julia
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Det flexibla livet som journalister älskar: En jämförelse mellan journalister på en tidning och radioredaktion i norra Sverige2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Abstract Title: “Journalists who loves the flexible life” - A case between journalists occupational

    perception and work-future who works at a newspaper compared to a radio station in northern Sweden.

    This study is a qualitative comparison between journalists without permanent employment on a commercial newspaper and a public service owned radio station in a medium sized town in northern Sweden. The main purpose was to analyse the occupational perception and work-future among young journalists without permanent employment in the public service and the commercial sector. Another intention was to figure out if there was any similarities or differences between working for a public service owned radio station compare to a commercial newspaper. We wanted to investigate how these journalists experience and manage their work and in which way they look at their own future and journalism in general. The research applies theories such as the precariat and studies about convergence. The chosen method for the study were qualitative semi-structured interviews based on the answers from six journalists and was processed through a thematic analysis.

    The main conclusion of this study was that multi journalism has become a part of the journalistic agenda, both on the radio station and the newspaper. It showed that journalists has to be flexible when it comes to working schedules. Even though they had to adapt to a lot of the journalistic requirement they still accepted the funny, but yet stressful life as a journalist. One conclusion that can be drawn is that todays journalism can demand almost anything, and job seeking journalists will adapt quite well regardless of change. A final conclusion was that it's difficult to predict the future of these journalists. But a common stand point for the journalists was that almost everyone could imagine a future in another profession.

  • Bergström, Tim
    et al.
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Eriksson, Jon
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Nationalism och Norrientalism: En diskursanalys av den norrländska självständighetsdebatten sensommaren 2016 och framåt2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The student thesis Nationalism and Norrientalism: A Discourse Analysis of the Norrlandic Independence Debate of Late Summer 2016 and Beyond aims to examine the style and content of the recent secession debate in the Swedish and Norrlandic printed press.

    From the late summer of 2016 to the beginning of 2017 the question of Norrlandic sovereignty was a prioritized topic in the legacy media debate, as well as in social media. It commenced after the Swedish government enterprise Vattenfall planned to relocate forty employment opportunities from Jokkmokk, raising the question of Norrlandic independence based on a post-colonialist view of the region. This thesis examines how the framing of Northern Sweden as a colony has been established, re-established or refuted in the different discourses of the printed debate, through a faceted lens composed of various theories of Orientalism and nationalism.

    Rooted in the discourse theory of Ernesto Laclau and Chantal Mouffe, merged with the critical discourse analysis of Norman Fairclough, and leaning against media theories of inoculation and framing, the study takes aim at the myths, metaphors, articulations and antagonisms which constituted the polemics in the printed press of the period.

    The results conclude that the debate revolved around independence, resources, and the myth regarding Norrland—often described as a barren landscape, marked by vast distances and a lack of social services. The term colony was used to describe Norrland as marginalised and robbed of its natural resources, whereas the term was met by opposition from the objecting side, who emphasised the historic and present representation of Norrlanders in high politics. The colonial identity was constituted in the press through internal Orientalism by Stockholm writers and self-Orientalisation by Norrlandic ones. The most distinct patterns of difference between the objecting side and the advocating side of independence was the determination of the real economic loser of a Norrlandic secession from Sweden.

  • Angvarson, Elin
    et al.
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Nilsson, Jesper
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Jag är inte porrmoralist, men...: En diskursanalys av pornografidebatten i svensk press år 20162017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The purpose of this essay is to investigate the opinions of pornography in the Swedish press 2016. To perform this, a quantitative method and discourse analysis on 139 published texts have been used. This study shows that the year of 2016 primarily is focused on a strong sence of concern about the effects of pornography rather than the industry itself, and the concerns are primarily rooted in anxiety of the effects on pornography-consumers, that is primarily young boys and men. The debate that is mainly represented by women with a great variety of work titles like scholars, criminologist, politicians, mothers, columnists, and film directors. The articles used for this study were found in newspapers and magazines from all over Sweden. When opinions about pornography is expressed it's usually a negative or critical opinions. If the opinion is positive or defending towards pornography it's usually a response to an already written negative or critical article. The critic is from different feminist theories, pro and counter arguments from both radical- and liberal feminism. Arguments that has its roots in the three counter waves during the 70's-, 80's- and 21's centrury is portrayed by the liberal feminist Petra Östergren in the publication Porr, Horor och Feminister. Some of the feminist arguments occur in contexts that describes the effects of pornography like something that inspire men and young boys to commit violent crimes. But there are also some arguments from the liberal feminist side that is more positive and that is arguing against the fact that women's pleasure is excluded from the male influenced debate. In the beginning of 2016 was the debate mostly focused on violence in pornography, that after a criminologist by the name Nina Rung published an article about sexuell crimes. During the summer the debate was mostly focused on sexual assaults due to the high numbers of assaults and harassments during the summer festivals. It will not be until october that the debate reached its heights, due to an article about the negative effects of pornography written by a group of politicians, tv-personalities and celebrities. Opinions that are possible to recognise during the rest of the year are adults and their concerns for kids and youths. A will to protect children and teenagers from pornography are strongly defined, but also a major discussion about sex norms and ideal in pornography are to be seen during 2016. The effect of pornography are also included in contexts like pornography- or emotional-impotence. An interesting part of the discourse analysis is the concept disclaimer. A linguistic discourse concept introduced by the researcher Teun A. van Dijk. The term have been used frequently by the counter porn critics. “I'm no moralist, but…” is an usual term used by the porn critics, something that could be used due to today's desire and habbit of building once’s own identity in our social media-opinion bubbles. 

  • Shah, Mansi
    et al.
    Cardenas, Ryan
    Wang, Belinda
    Persson, Jenny
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Mongan, Nigel P.
    Grabowska, Anna
    Allegrucci, Cinzia
    HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells2017In: Molecular Cancer, ISSN 1476-4598, E-ISSN 1476-4598, Vol. 16, 38Article in journal (Refereed)
    Abstract [en]

    Background: Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissues. Here, we screened the expression of homeobox genes in mammary stem cells to establish their role in stem cells transformation in breast cancer. Methods: Using a Homeobox Genes PCR array, we screened 83 homeobox genes in normal cancer breast stem/progenitor cells isolated by flow cytometry. The candidate gene HOXC8 epigenetic regulation was studied by DNA methylation and miRNA expression analyses. Self-renewal and differentiation of HOXC8-overexpressing or knockdown cells were assessed by flow cytometry and mammosphere, 3D matrigel and soft agar assays. Clinical relevance of in vitro findings were validated by bioinformatics analysis of patient datasets from TCGA and METABRIC studies. Results: In this study we demonstrate altered expression of homeobox genes in breast cancer stem/progenitor cells. HOXC8 was consistently downregulated in stem/progenitor cells of all breast molecular subtypes, thus representing an interesting tumour suppressor candidate. We show that downregulated expression of HOXC8 is associated with DNA methylation at the gene promoter and expression of miR196 family members. Functional studies demonstrated that HOXC8 gain of function induces a decrease in the CD44(+)/CD24(-/low) cancer stem cell population and proportion of chemoresistant cells, with a concomitant increase in CD24(+) differentiated cells. Increased HOXC8 levels also decrease the ability of cancer cells to form mammospheres and to grow in anchorage-independent conditions. Furthermore, loss of HOXC8 in non-tumorigenic mammary epithelial cells expands the cancer stem/progenitor cells pool, increases stem cell self-renewal, prevents differentiation induced by retinoic acid and induces a transformed phenotype. Conclusions: Taken together, our study points to an important role of homeobox genes in breast cancer stem/progenitor cell function and establishes HOXC8 as a suppressor of stemness and transformation in the mammary gland lineage.

  • Coe, Anna-Britt
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    The importance of taking into account different perspectives of a health problem: the case of fibromyalgia2017In: Global Health Action, ISSN 1654-9716, E-ISSN 1654-9880, Vol. 10, 1275189Article in journal (Refereed)
  • Hagglund, Anna-Carin
    et al.
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Jones, Iwan
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Carlsson, Leif
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    A novel mouse model of anterior segment dysgenesis (ASD): conditional deletion of Tsc1 disrupts ciliary body and iris development2017In: Disease Models and Mechanisms, ISSN 1754-8403, E-ISSN 1754-8411, Vol. 10, no 3, 245-257 p.Article in journal (Refereed)
    Abstract [en]

    Development of the cornea, lens, ciliary body and iris within the anterior segment of the eye involves coordinated interaction between cells originating from the ciliary margin of the optic cup, the overlying periocular mesenchyme and the lens epithelium. Anterior segment dysgenesis (ASD) encompasses a spectrum of developmental syndromes that affect these anterior segment tissues. ASD conditions arise as a result of dominantly inherited genetic mutations and result in both ocular-specific and systemic forms of dysgenesis that are best exemplified by aniridia and Axenfeld-Rieger syndrome, respectively. Extensive clinical overlap in disease presentation amongst ASD syndromes creates challenges for correct diagnosis and classification. The use of animal models has therefore proved to be a robust approach for unravelling this complex genotypic and phenotypic heterogeneity. However, despite these successes, it is clear that additional genes that underlie several ASD syndromes remain unidentified. Here, we report the characterisation of a novel mouse model of ASD. Conditional deletion of Tsc1 during eye development leads to a premature upregulation of mTORC1 activity within the ciliary margin, periocular mesenchyme and lens epithelium. This aberrant mTORC1 signalling within the ciliary margin in particular leads to a reduction in the number of cells that express Pax6, Bmp4 and Msx1. Sustained mTORC1 signalling also induces a decrease in ciliary margin progenitor cell proliferation and a consequent failure of ciliary body and iris development in postnatal animals. Our study therefore identifies Tsc1 as a novel candidate ASD gene. Furthermore, the Tsc1-ablated mouse model also provides a valuable resource for future studies concerning the molecular mechanisms underlying ASD and acts as a platform for evaluating therapeutic approaches for the treatment of visual disorders.

  • Athanasiu, Lavinia
    et al.
    Giddaluru, Sudheer
    Fernandes, Carla
    Christoforou, Andrea
    Reinvang, Ivar
    Lundervold, Astri J.
    Nilsson, Lars-Göran
    Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Aging Research Center, Karolinska Institutet, Stockholm, Sweden.
    Kauppi, Karolina
    Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
    Adolfsson, Rolf
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
    Eriksson, Elias
    Sundet, Kjetil
    Djurovic, Srdjan
    Espeseth, Thomas
    Nyberg, Lars
    Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Department of Radiation Sciences.
    Steen, Vidar M.
    Andreassen, Ole A.
    Le Hellard, Stephanie
    A genetic association study of CSMD1 and CSMD2 with cognitive function2017In: Brain, behavior, and immunity, ISSN 0889-1591, E-ISSN 1090-2139, Vol. 61, 209-216 p.Article in journal (Refereed)
    Abstract [en]

    The complement cascade plays a role in synaptic pruning and synaptic plasticity, which seem to be involved in cognitive functions and psychiatric disorders. Genetic variants in the closely related CSMD1 and CSMD2 genes, which are implicated in complement regulation, are associated with schizophrenia. Since patients with schizophrenia often show cognitive impairments, we tested whether variants in CSMD1 and CSMD2 are also associated with cognitive functions per se. We took a discovery-replication approach, using well-characterized Scandinavian cohorts. A total of 1637 SNPs in CSMD1 and 206 SNPs in CSMD2 were tested for association with cognitive functions in the NCNG sample (Norwegian Cognitive NeuroGenetics; n = 670). Replication testing of SNPs with p-value < 0.001 (7 in CSMD1 and 3 in CSMD2) was carried out in the TOP sample (Thematically Organized Psychosis; n =1025) and the BETULA sample (Betula Longitudinal Study on aging, memory and dementia; n = 1742). Finally, we conducted a meta-analysis of these SNPs using all three samples. The previously identified schizophrenia marker in CSMD1 (SNP rs10503253) was also included. The strongest association was observed between the CSMDI SNP rs2740931 and performance in immediate episodic memory (p-value = 5 Chi 10(-6), minor allele A, MAF 0.48-0.49, negative direction of effect). This association reached the study-wide significance level (p <= 1.2 Chi 10(-5)). SNP rs10503253 was not significantly associated with cognitive functions in our samples. In conclusion, we studied n = 3437 individuals and found evidence that a variant in CSMD1 is associated with cognitive function. Additional studies of larger samples with cognitive phenotypes will be needed to further clarify the role of CSMD1 in cognitive phenotypes in health and disease.

  • Ameh, Soter
    et al.
    Klipstein-Grobusch, Kerstin
    D'ambruoso, Lucia
    Kahn, Kathleen
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. Medical Research Council/Wits University Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; The International Network for the Demographic Evaluation of Populations and Their Health in Developing Countries (INDEPTH) Accra, Ghana.
    Tollman, Stephen M.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. Medical Research Council/Wits University Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; The International Network for the Demographic Evaluation of Populations and Their Health in Developing Countries (INDEPTH) Accra, Ghana.
    Gomez-Olive, Francesc Xavier
    Quality of integrated chronic disease care in rural South Africa: user and provider perspectives2017In: Health Policy and Planning, ISSN 0268-1080, E-ISSN 1460-2237, Vol. 32, no 2, 257-266 p.Article in journal (Refereed)
    Abstract [en]

    The integrated chronic disease management (ICDM) model was introduced as a response to the dual burden of HIV/AIDS and non-communicable diseases (NCDs) in South Africa, one of the first of such efforts by an African Ministry of Health. The aim of the ICDM model is to leverage HIV programme innovations to improve the quality of chronic disease care. There is a dearth of literature on the perspectives of healthcare providers and users on the quality of care in the novel ICDM model. This paper describes the viewpoints of operational managers and patients regarding quality of care in the ICDM model. In 2013, we conducted a case study of the seven PHC facilities in the rural Agincourt sub-district in northeast South Africa. Focus group discussions (n = 8) were used to obtain data from 56 purposively selected patients >= 18 years. In-depth interviews were conducted with operational managers of each facility and the sub-district health manager. Donabedian's structure, process and outcome theory for service quality evaluation underpinned the conceptual framework in this study. Qualitative data were analysed, with MAXQDA 2 software, to identify 17 a priori dimensions of care and unanticipated themes that emerged during the analysis. The manager and patient narratives showed the inadequacies in structure (malfunctioning blood pressure machines and staff shortage); process (irregular prepacking of drugs); and outcome (long waiting times). There was discordance between managers and patients regarding reasons for long patient waiting time which managers attributed to staff shortage and missed appointments, while patients ascribed it to late arrival of managers to the clinics. Patients reported anti-hypertension drug stock-outs (structure); sub-optimal defaulter-tracing (process); rigid clinic appointment system (process). Emerging themes showed that patients reported HIV stigmatisation in the community due to defaulter-tracing activities of home-based carers, while managers reported treatment of chronic diseases by traditional healers and reduced facility-related HIV stigma because HIV and NCD patients attended the same clinic. Leveraging elements of HIV programmes for NCDs, specifically hypertension management, is yet to be achieved in the study setting in part because of malfunctioning blood pressure machines and anti-hypertension drug stock-outs. This has implications for the nationwide scale up of the ICDM model in South Africa and planning of an integrated chronic disease care in other low-and middle-income countries.

  • Markström, Sanna
    Umeå University, Faculty of Arts, Department of culture and media studies.
    När reklamen kliver in i samhällsdebatten: En kvalitativ analys av Åhléns kampanj Bryt klädmaktsordningen2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The purpose of this study is to examine how Åhléns challenge existing gender norms and stereotypes in their campaign Bryt klädmaktsordningen. The study also wish to highlight the reactions that the campaign has received on Åhléns Facebook-page. The theoretical starting point is based on theories concerning representation and stereotypes and specifically how these theories can be seen in the context of advertising campaigns. The concepts of norms and norms criticism has been established and the concept of sex and gender has been discussed within the theoretical framework. Theories of semiotics has also been presented to provide a basis to the two qualitative methods in the study. First, a semiotic picture analysis is used to analyze the visual elements of the material. Then, a thematic text analysis is used to analyze the textual material consisted of comments from the Facebook-page. The result of the semiotic analysis shows that Åhléns challenge gender norms and stereotypes by presenting women and men in contrary to what is expected of them. A part of the result that was found a bit surprising is that the analysis also shows that the presentation is not entirely equitable between the men and women. The result of the thematic text analysis is first categorised into five different themes: “shouts of encouragement”, “keep politics away!”, “threats of boycott”, “great, but…” and “campaign defender”. The result shows that the reactions largely stands for or against Åhléns, this campaign or norm critical advertising. A surprising result was those who both praised and condemned Åhléns or campaign in the same comment. Based on the result, the conclusion is that Åhléns can participate and highlight social problems through their marketing communication and that they have done so by challenging the previling norms in the camaign. The fact that Åhléns has chosen to take a stand on gender norms through this campaign also shows that a norm critical advertising campaign can lead to a community discussion regarding prevailing gender norms. 

  • Eklund, Julia
    et al.
    Umeå University, Faculty of Arts, Department of culture and media studies.
    Jaako, Amanda
    Umeå University, Faculty of Arts, Department of culture and media studies.
    "De har ju ett syfte med allt de gör": En kvalitativ studie av IKEAs reklamserie Där livet händer2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Is commercialism a threat to authenticity? This is a qualitative research method and study of IKEAs advertising series Där livet händer. To appear genuine and authentic has become highly important for companies and brands. Critical consumption discourses makes it harder for companies to be perceived as genuine.

    Där livet händer was launched autumn of 2016 by IKEA Sweden. An advertising series with a concept that aims to represent swedes in their everyday life. The creators of the production worked to avoid traditional language within advertising, instead they wanted to achieve an authentic expression.

    This study aims to get a better and deeper understanding of advertising where the producer strives for authentic expression. To fulfill the purpose of the study we have used a semiotic analysis of the series Där livet händer, and done qualitative group interviews with different types of consumer groups with different kinds of perspectives on consumption. The theoretical framework for this study is based on Jenkins theory about convergence, Bauman’s theory about consumption culture and Fairclough’s critical discourse analysis.

    This study shows that the consumer’s individual identity projects through consumption controls how they perceive commercial messages. Brands can through authentic expression, as in authentic recognition, reach different types of consumer groups. To be perceived as authentic, however, seems to be more difficult. Especially if you want to reach consumer groups with more critical perspectives on mass consumption. The home is central in the IKEA commercials, it is also strongly related to the origin, presence and human identity. By recognition linked to the nuclear family and the home, IKEA has more or less managed to affect the different consumer groups in this study. 

  • Norqvist, Lars
    et al.
    Umeå University, Faculty of Social Sciences, Department of applied educational science.
    Leffler, Eva
    Umeå University, Faculty of Social Sciences, Department of Education.
    Learning in non-formal education: is it ‘‘youthful’’for youth in action?2017In: International Review of Education, ISSN 0020-8566, E-ISSN 1573-0638, Vol. 63, no 2, 235-256 p.Article in journal (Refereed)
    Abstract [en]

    This article offers insights into the practices of a non-formal education programme for youth provided by the European Union (EU). It takes a qualitative approach and is based on a case study of the European Voluntary Service (EVS). Data were collected during individual and focus group interviews with learners (the EVS volunteers), decision takers and trainers, with the aim of deriving an understanding of learning in non-formal education. The research questions concerned learning, the recognition of learning and perspectives of usefulness. The study also examined the Youthpass documentation tool as a key to understanding the recognition of learning and to determine whether the learning was useful for learners (the volunteers). The findings and analysis offer several interpretations of learning, and the recognition of learning, which take place in non-formal education. The findings also revealed that it is complicated to divide learning into formal and non-formal categories; instead, non-formal education is useful for individual learners when both formal and non-formal educational contexts are integrated. As a consequence, the division of formal and non-formal (and possibly even informal) learning creates a gap which works against the development of flexible and interconnected education with ubiquitous learning and mobility within and across formal and non-formal education. This development is not in the best interests of learners, especially when seeking useful learning and education for youth (what the authors term “youthful” for youth in action).

  • Dahlin, Lars B.
    et al.
    Andersson, Gert
    Backman, Clas
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Hand Surgery. Department of Hand Surgery, University Hospital of Northern Sweden, Umeå University, Umeå, Sweden.
    Svensson, Hampus
    Bjorkman, Anders
    Rehabilitation, Using Guided Cerebral plasticity, of a Brachial plexus Injury treated with Intercostal and phrenic Nerve transfers2017In: Frontiers in Neurology, ISSN 1664-2295, E-ISSN 1664-2295, Vol. 8, 72Article in journal (Refereed)
    Abstract [en]

    Recovery after surgical reconstruction of a brachial plexus injury using nerve grafting and nerve transfer procedures is a function of peripheral nerve regeneration and cerebral reorganization. A 15-year-old boy, with traumatic avulsion of nerve roots C5-C7 and a non-rupture of C8-T1, was operated 3 weeks after the injury with nerve transfers: ( a) terminal part of the accessory nerve to the suprascapular nerve, (b) the second and third intercostal nerves to the axillary nerve, and (c) the fourth to sixth intercostal nerves to the musculocutaneous nerve. A second operation-free contralateral gracilis muscle transfer directly innervated by the phrenic nerve-was done after 2 years due to insufficient recovery of the biceps muscle function. One year later, electromyography showed activation of the biceps muscle essentially with coughing through the intercostal nerves, and of the transferred gracilis muscle by deep breathing through the phrenic nerve. Voluntary flexion of the elbow elicited clear activity in the biceps/gracilis muscles with decreasing activity in intercostal muscles distal to the transferred intercostal nerves (i.e., corresponding to eighth intercostal), indicating cerebral plasticity, where neural control of elbow flexion is gradually separated from control of breathing. To restore voluntary elbow function after nerve transfers, the rehabilitation of patients operated with intercostal nerve transfers should concentrate on transferring coughing function, while patients with phrenic nerve transfers should focus on transferring deep breathing function.

  • Juliusson, G.
    et al.
    Abrahamsson, J.
    Lazarevic, V.
    Antunovic, P.
    Derolf, A.
    Garelius, H.
    Lehmann, S.
    Myhr-Eriksson, K.
    Mollgard, L.
    Uggla, B.
    Wåhlin, Anders
    Umeå University, Faculty of Medicine, Department of Radiation Sciences.
    Wennstrom, L.
    Hoglund, M.
    Prevalence and characteristics of survivors from acute myeloid leukemia in Sweden2017In: Leukemia, ISSN 0887-6924, E-ISSN 1476-5551, Vol. 31, no 3, 728-731 p.Article in journal (Refereed)
  • Krajewski, Stefanie Sandra
    et al.
    Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Isoz, Isabelle
    Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Johansson, Jörgen
    Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    Antibacterial and antivirulence effect of 6-N-hydroxylaminopurine in Listeria monocytogenes2017In: Nucleic Acids Research, ISSN 0305-1048, E-ISSN 1362-4962, Vol. 45, no 4, 1914-1924 p.Article in journal (Refereed)
    Abstract [en]

    The emerging development of antibiotic resistant bacteria calls for novel types of antibacterial agents. In this work we examined the putative antibacterial effect of purine analogs in Listeria monocytogenes. We show that, among several tested purine analogs, only 6-N-hydroxylaminopurine (6-N-HAP) reduces the viability of the Gram-positive pathogenListeria monocy-togenes. As in Bacillus subtilis, 6-N-HAP terminates expression at guanine riboswitches in L. monocyto-genes hence preventing expression of their downstream genes. However, we show that the bacteriocidal effect of the compound was unlinked to the terminated expression at the guanine riboswitches. When further examining the antimicrobial effect, we observed that 6-N-HAP acts as a potent mutagen in L. monocytogenes, by increasing the mutation rate and inducing the SOS-response. Also, addition of 6N-HAP decreased virulence gene expression by reducing both the levels and activity of the virulence regulator PrfA.

  • Vogelzang, Nicholas J.
    et al.
    Coleman, Robert E.
    Michalski, Jeff M.
    Nilsson, Sten
    O'Sullivan, Joe M.
    Parker, Christopher
    Widmark, Anders
    Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
    Thuresson, Marcus
    Xu, Lei
    Germino, Joseph
    Sartori, Oliver
    Hematologic Safety of Radium-223 Dichloride: Baseline Prognostic Factors Associated With Myelosuppression in the ALSYMPCA Trial2017In: Clinical Genitourinary Cancer, ISSN 1558-7673, E-ISSN 1938-0682, Vol. 15, no 1, 42-52 p.Article in journal (Refereed)
    Abstract [en]

    Radium-223 was minimally myelosuppressive. Multivariate analyses of data from ALSYMPCA patients identified baseline factors that may increase hematologic toxicity risk with radium-223. Extent of disease and degree of prostate-specific antigen elevation were predictive of grade 2-4 anemia; prior docetaxel, and decreased hemoglobin and platelets were predictive of grade 2-4 thrombocytopenia. Patients with these factors should be closely monitored during radium-223 therapy. Background: Myelosuppression is common in patients with progressive castration-resistant prostate cancer and bone metastases. Radium-223 prolongs overall survival in these patients but may cause myelosuppression; understanding risk factors will improve clinical decision making. We describe hematologic safety of radium-223 in ALSYMPCA and post hoc analyses identifying patients at increased risk for hematologic toxicity. Patients and Methods: Hematologic parameters and adverse events were analyzed. Multivariate analyses assessing baseline risk factors for hematologic toxicities were performed separately for radium-223 and placebo patients. Results: Nine hundred one patients received radium-223 (n = 600) or placebo (n = 301); 65% of radium-223 and 48% of placebo patients had the full 6 cycles. Grade 3/4 thrombocytopenia was more common in radium-223 versus placebo patients (6% vs. 2%). Logistic regression analyses identified significant baseline predictors for grade 2-4 hematologic toxicities related to radium-223 treatment: extent of disease (6-20 vs. < 6 bone metastases; odds ratio [OR] = 2.76; P = .022) and elevated prostate-specific antigen (OR = 1.65; P = .006) for anemia; prior docetaxel (OR = 2.16; P = .035), decreased hemoglobin (OR = 1.35; P = .008), and decreased platelets (OR = 1.44; P = .030) for thrombocytopenia. Neutropenia events were too few in placebo patients for a comparative analysis. There were no significant associations between hematologic toxicities and number of radium-223 injections received (4-6 vs. 1-3). Conclusion: Radium-223 has a favorable safety profile with a low myelosuppression incidence. Understanding baseline factors associated with myelosuppression may assist clinicians in avoiding severe myelosuppression events with radium-223.

  • Zhang, Xiangwei
    et al.
    Wang, Yang
    Li, Cheng
    Helmersson, Jing
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Jiang, Yuanzhu
    Ma, Guoyuan
    Wang, Guanghui
    Dong, Wei
    Sang, Shaowei
    Du, Jiajun
    The prognostic value of tumor length to resectable esophageal squamous cell carcinoma: a retrospective study2017In: PeerJ, ISSN 2167-8359, E-ISSN 2167-8359, Vol. 5, e2943Article in journal (Refereed)
    Abstract [en]

    Background: The current TNM classification system does not consider tumor length for patients with esophageal carcinoma (EC). This study explored the effect of tumor length, in addition to tumor depth and lymph node involvement, on survival in patients with esophageal squamous cell carcinoma (ESCC).

    Methods: A total of 498 ESCC patients who underwent surgical resection as the primary treatment were selected in the retrospective study. Pathological details were collected, which included tumor type, TNM stage, differentiation. Other collected information were: the types of esophageal resection, ABO blood group, family history and demographic and lifestyle factors. A time-dependent receiver operating characteristic (ROC) curve and a regression tree for survival were used to identify the cut-off point of tumor length, which was 3 cm. Univariate and multivariate Cox proportional hazard regression models were used to identify the prognostic factors to ESCC.

    Results & Discussion: The 1-, 3-, 5-year overall survival rates were found to be 82.5%, 55.6%, and 35.1%, respectively. Patients who had larger tumor length (>3 cm) had a higher risk for death than the rest patients. From the univariate Cox proportional hazards regression model, the overall survival rate was significantly influenced by the depth of the tumor and lymph node involvement (either as dummy or continuous variables), Sex, and tumor length. Using these four variables in the multivariate Cox proportional hazard regression model, we found that the overall survival was significantly influenced by all variables except Sex. Therefore, in addition to the depth of the tumor and lymph node involvement (as either dummy or continuous variables), the tumor length is also an independent prognostic factor for ESCC. The overall survival rate was higher in a group with smaller tumor length (≤3 cm) than those patients with larger tumor length (>3 cm), no matter what the tumor stage was.

    Conclusion: The tumor length was found to be an important prognostic factor for ESCC patients without receiving neoadjuvant therapy. The modification of EC staging system may consider tumor length to better predict ESCC survival and identify higher risk patients for postoperative therapy.

  • Sundh, Josefin
    et al.
    Janson, Christer
    Johansson, Gunnar
    Linden, Anders
    Lofdahl, Claes-Goran
    Sandström, Thomas
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Larsson, Kjell
    Characterization of secondary care for COPD in Sweden2017In: European Clinical Respiratory Journal, ISSN 2001-8525, Vol. 4, 1270079Article in journal (Refereed)
    Abstract [en]

    Introduction: Only a selected proportion of chronic obstructive pulmonary disease (COPD) patients are managed in secondary care. The aim of this study was to characterize disease severity, treatment and structure of secondary care for COPD in Sweden.

    Methods: Information was collected from 29 of 33 existing secondary care units of respiratory medicine in Sweden, using both individual data from 373 consecutively enrolled COPD patients with Global initiative on Obstructive Lung Disease (GOLD) stage III–IV and a structural questionnaire about available resources at the units. Patient data included exacerbations, health status assessed by COPD Assessment Test (CAT), lung function, comorbid conditions, pharmacological treatment and vaccinations. Structural data included available smoking cessation support, multidisciplinary rehabilitation, physical training, patient education and routine follow-up after exacerbations at the respective unit. All patients were reclassified according to the GOLD 2014 group A–D classification. Multiple linear regression investigated associations of available resources with number of exacerbations and CAT score.

    Results: According to GOLD 2014, 87% of the population were GOLD D and 13% were GOLD C. Triple inhaled therapy were prescribed in 88% of the patients. Over 75% of the units had resources for smoking cessation, multidisciplinary rehabilitation, physical training and patient education. Routine follow-up after exacerbations was available in 35% of the units. Being managed at units with access to structured patient education was associated with statistically significantly fewer exacerbations (adjusted regression coefficient (95% confidence interval) −0.79 (−1.39 to −0.19), p = 0.010).

    Conclusion: Most stage III–IV COPD patients managed at secondary care respiratory units in Sweden have maximized inhaled therapy and high risk disease even when reclassified according to GOLD 2014. Most units have access to smoking cessation, rehabilitation and patient education. Patients managed at units with structured patient education have a lower exacerbation risk.

  • Public defence: 2017-05-04 09:30 KBE301, Lilla Hörsalen (KBC), Umeå
    Vasconcelos, Francisco Rivera
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Effects of warming and browning on benthic and pelagic ecosystem components in shallow lakes2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The majority of lakes on Earth are shallow, unproductive and located at high latitudes. These lakes are experiencing big changes due to climate change, where two environmental drivers operate simultaneously, browning and warming. How they affect lake ecosystems is not well understood. Here, I addressed this issue by using a theoretical and an experimental approach. In particular, I generated model predictions and compared them with the results of a realistic large-scale experiment, where browning and warming were manipulated in a factorial design. In addition, model outcomes were compared with data from 12 unproductive lakes sampled along a gradient of browning. Another novelty of my thesis is that it integrates benthic and pelagic food web components in the model and experimental approaches. I found that browning affected the resources availability for benthic and pelagic producers in the model and in the experiment. With browning, benthic primary producers became increasingly light limited and declined, while pelagic producers became less nutrient limited and increased. Pelagic nutrient limitation was alleviated by two non-exclusive mechanisms. Browning directly enriched the water with nutrients, and browning indirectly increased the nutrient flowing from the sediment to the pelagic habitat via suppression of benthic producers. To tease apart these two mechanisms I applied structural equation modeling (SEM). The indirect evidence by SEM suggests that both mechanisms contributed equally to the pelagic nutrient concentration in the experiment. Interestingly, a model food web with only primary producers shows similar qualitative behavior as a food web with grazers and carnivores included. This happens because carnivorous fish exert strong top-down control in the more productive habitat, which relaxes grazing pressure on primary producers and increases resource limitation in the adjacent habitat. Biomass of benthic and pelagic consumers followed the same pattern as their resources. The lake data were largely congruent with model expectations and supported the findings of the experiment. Furthermore, the model also predicted a negative relationship between total phosphorus and both primary and fish production, which was observed across the 12 lakes. Warming effects were more complex. The model predicts that warming effects should depend on browning and are expected to be strongest in the more productive of the two (benthic and pelagic) habitats. For example, at low levels of browning the biomasses of benthic algae and fish are expected to decline with warming, which was observed in the experiment. In contrast, observed warming effects at high levels of browning deviated from model expectations. The mechanisms by which browning and warming interactively affect lake food webs are still poorly understood. This thesis offers a conceptual foundation for their further study through the integration of within- and between-habitat interactions.

  • Hartvik, Anna
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Förutsättningar att skapa en god psykosocial arbetsmiljö: Hinder och hjälpmedel som prefekter upplever i det systematiska arbetsmiljöarbetet2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The aim of this study was to investigate the conditions that Heads of Department are facing when conducting Systematic Work Environment Management (SWEM) within psychosocial work environment at Umeå University. The study has focused on the obstacles and tools that Heads of Department are experiencing in their efforts to investigate, assess, and measures to reduce risks and follow up actions in the psychosocial work environment. To investigate this, I conducted semi-structured interviews with four Heads of Department and a Head of Unit at Umeå University. The interviews were recorded, transcribed and analysed. The result of the study is that dialogue and cooperation on different levels of the workplace seems to be the foundation of their SWEM within psychosocial work environment. A relationship-oriented leadership, good communication climate at the workplace, and various support functions are also important tools. Some of the obstacles that they experience are heavy workload, performance cultures, and sometimes lack of central support. SWEM also seems to be more time-consuming within psychosocial work environment than within the physical environment. It is not possible to draw any general conclusions from this study, but it has indicated several tracks that might be interesting to investigate further to improve conditions for the Heads of Department. For example, to further map their psychosocial environment, if the central support is perceived as sufficient and how to safeguard the local support from, for example, human resources specialists and work safety representatives.

  • Enthoven, Paul
    et al.
    Molander, Peter
    Oberg, Birgitta
    Stålnacke, Britt-Marie
    Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Rehabilitation Medicine. Department of Clinical Sciences, Karolinska Institutet and Department of Rehabilitation Medicine, Danderyd Hospital, Stockholm, Sweden.
    Stenberg, Gunilla
    Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Physiotherapy.
    Gerdle, Bjorn
    DO PAIN CHARACTERISTICS GUIDE SELECTION FOR MULTIMODAL PAIN REHABILITATION?2017In: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 49, no 2, 161-169 p.Article in journal (Refereed)
    Abstract [en]

    Objective: To determine whether self-reported pain measures are associated with selection for multimodal or multidisciplinary rehabilitation (MMR) and whether this selection is influenced by sex. Design: Cross-sectional cohort study. Subjects: A total of 1,226 women and 464 men with chronic pain conditions from 2 university hospitals. Methods: Drawing from the Swedish Quality Registry for Pain Rehabilitation (SQRP), data on pain, psychological symptoms, function, health, and activity/participation were collected. Multiple logistic regression was used to investigate association of pain measures with selection for MMR (no/yes) after multidisciplinary assessment. Covariates were: age, educational level, anxiety, depression, working status, and several pain measures. Results: High pain intensity in the previous week (odds ratio (OR) 0.92; 95% confidence interval (CI) 0.86-0.99) and high pain severity (Multidimensional Pain Inventory) (OR 0.83; 95% CI 0.74-0.95) were negatively associated with selection for MMR, whereas higher number of pain quadrants was positively associated with selection for MMR. Similar results were obtained for women, but none of the measures was predictive for men. Conclusion: This practice-based study showed that higher scores on self-reported pain were not associated with selection for MMR, and in women there was a negative association for higher pain intensity and pain severity. Thus, other factors than pain determine whether patients are selected for MMR.

  • Boldrup, Linda
    et al.
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Gu, Xiaolian
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Coates, Philip J.
    Norberg-Spaak, Lena
    Umeå University, Faculty of Medicine, Department of Clinical Sciences.
    Fåhraeus, Robin
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology. RECAMO, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic; Institut de Génétique Moléculaire, Université Paris 7, Hôpital St. Louis, 75010 Paris, France.
    Laurell, Göran
    Umeå University, Faculty of Medicine, Department of Clinical Sciences. Department of Surgical Sciences/ENT, Uppsala University, 752 36 Uppsala, Sweden.
    Wilms, Torben
    Umeå University, Faculty of Medicine, Department of Clinical Sciences.
    Nylander, Karin
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma2017In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 8, no 12, 19389-19402 p.Article in journal (Refereed)
    Abstract [en]

    Due to the high frequency of loco-regional recurrences, which could be explained by changes in the field surrounding the tumor, patients with squamous cell carcinoma of head and neck show poor survival. Here we identified a total of 554 genes as dysregulated in clinically tumor free tongue tissue in patients with tongue tumors when compared to healthy control tongue tissue. Among the top dysregulated genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36). Data suggest that these are important findings which can aid in earlier diagnosis of tumor development, a relapse or a novel squamous cell carcinoma of the tongue, in the absence of histological signs of a tumor.