umu.sePublikasjoner
12345 1 - 50 of 234
rss atomLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
  • Mauk, Tais
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Designhögskolan vid Umeå universitet.
    Code Roads: Teaching Kids Coding Fundamentals With Tangible Interaction2016Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
    Abstract [en]

    What if a computer wasn’t necessarily the best place for kids to learn the fundamentals of coding? A new wave of digital coding teaching tools has been ushered into America, with the country progressively gaining more interest in having kids learn code. 

    The goal of this project has been to propose an alternative teaching method, one focused and tailored to students who learn best through kinesthetic and visual means. 

    The approach has been to combine tangible interaction principles to help make the introductory stages of learning code as approachable and intuitive as possible. 

    The final result of this thesis is a modular toy system which gradually introduces kids to the fundamentals of coding independent of a computer, prompting exploration and problem solving.

  • Vikström, Julia
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik.
    Kanwar, Jenny
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik.
    Arbetsro i matematikklassrummet: Metoder som lärare använder för att påverka arbetsron2017Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [sv]

    Syftet med undersökningen var att, ur ett lärarperspektiv, öka kunskapen om hur mellanstadielärare använder metoder för att främja arbetsro under matematiklektioner. Undersökningen genomfördes genom observationer och kvalitativa intervjuer med matematiklärare i årskurs 4-6 vid fyra olika skolor i en stad i norra Sverige. Genom observationer framgick det att lärarna främjade arbetsron genom att värna om sina elevrelationer. Utifrån intervjuer framgick det av samtliga lärare att deras definition av arbetsro var när eleverna var fokuserade på ämnet. Resultatet av intervjuerna visade att matematiklärare anser att kommunikation, tydlighet och rutiner är viktiga aspekter för att främja arbetsron.

  • Pawar, Prashant Mohan-Anupama
    et al.
    Derba-Maceluch, Marta
    Chong, Sun-Li
    Gandla, Madhavi Latha
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Bashar, Shamrat Shafiul
    Sparrman, Tobias
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Ahvenainen, Patrik
    Hedenström, Mattias
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Ozparpucu, Merve
    Ruggeberg, Markus
    Serimaa, Ritva
    Lawoko, Martin
    Tenkanen, Maija
    Jönsson, Leif J.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Mellerowicz, Ewa J.
    In muro deacetylation of xylan affects lignin properties and improves saccharification of aspen wood2017Inngår i: Biotechnology for Biofuels, ISSN 1754-6834, E-ISSN 1754-6834, Vol. 10, 98Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Lignocellulose from fast growing hardwood species is a preferred source of polysaccharides for advanced biofuels and “green” chemicals. However, the extensive acetylation of hardwood xylan hinders lignocellulose saccharification by obstructing enzymatic xylan hydrolysis and causing inhibitory acetic acid concentrations during microbial sugar fermentation. To optimize lignocellulose for cost-effective saccharification and biofuel production, an acetyl xylan esterase AnAXE1 from Aspergillus niger was introduced into aspen and targeted to cell walls.

    Results: AnAXE1-expressing plants exhibited reduced xylan acetylation and grew normally. Without pretreatment, their lignocellulose yielded over 25% more glucose per unit mass of wood (dry weight) than wild-type plants. Glucose yields were less improved (+7%) after acid pretreatment, which hydrolyses xylan. The results indicate that AnAXE1 expression also reduced the molecular weight of xylan, and xylan–lignin complexes and/or lignin co-extracted with xylan, increased cellulose crystallinity, altered the lignin composition, reducing its syringyl to guaiacyl ratio, and increased lignin solubility in dioxane and hot water. Lignin-associated carbohydrates became enriched in xylose residues, indicating a higher content of xylo-oligosaccharides.

    Conclusions: This work revealed several changes in plant cell walls caused by deacetylation of xylan. We propose that deacetylated xylan is partially hydrolyzed in the cell walls, liberating xylo-oligosaccharides and their associated lignin oligomers from the cell wall network. Deacetylating xylan thus not only increases its susceptibility to hydrolytic enzymes during saccharification but also changes the cell wall architecture, increasing the extractability of lignin and xylan and facilitating saccharification.

  • Kristen, Arnt V.
    et al.
    Maurer, Mathew S.
    Rapezzi, Claudio
    Mundayat, Rajiv
    Suhr, Ole B.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Damy, Thibaud
    Impact of genotype and phenotype on cardiac biomarkers in patients with transthyretin amyloidosis - Report from the Transthyretin Amyloidosis Outcome Survey (THAOS)2017Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, nr 4, e0173086Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aim: Cardiac troponins and natriuretic peptides are established for risk stratification in light-chain amyloidosis. Data on cardiac biomarkers in transthyretin amyloidosis (ATTR) are lacking.

    Methods and results: Patients (n = 1617) with any of the following cardiac biomarkers, BNP (n = 1079), NT-proBNP (n = 550), troponin T (n = 274), and troponin I (n = 108), available at baseline in the Transthyretin Amyloidosis Outcomes Survey (THAOS) were analyzed for differences between genotypes and phenotypes and their association with survival. Median level of BNP was 68.0 pg/mL (IQR 30.5–194.9), NT-proBNP 337.9 pg/mL (IQR 73.0–2584.0), troponin T 0.03 μg/L (IQR 0.01–0.05), and troponin I 0.08 μg/L (IQR 0.04–0.13). NT-proBNP and BNP were higher in wild-type than mutant-type ATTR, troponin T and I did not differ, respectively. Non-Val30Met patients had higher BNP, NT-proBNP and troponin T levels than Val30Met patients, but not troponin I. Late-onset Val30Met was associated with higher levels of troponin I and troponin T compared with early-onset. 115 patients died during a median follow-up of 1.2 years. Mortality increased with increasing quartiles (BNP/NT-proBNP Q1 = 1.7%, Q2 = 5.2%, Q3 = 21.7%, Q4 = 71.3%; troponin T/I Q1 = 6.5%, Q2 = 14.5%, Q3 = 33.9%, Q4 = 45.2%). Three-year overall-survival estimates for BNP/NT-proBNP and troponin T/I quartiles differed significantly (p<0.001). Stepwise risk stratification was achieved by combining NT-proBNP/BNP and troponin T/I. From Cox proportional hazards model, age, modified body mass index, mutation (Val30Met vs. Non-Val30Met) and BNP/NT-proBNP (Q1–Q3 pooled vs. Q4) were identified as independent predictors of survival in patients with mutant-type ATTR.

    Conclusions: In this ATTR patient cohort, cardiac biomarkers were abnormal in a substantial percentage of patients irrespective of genotype. Along with age, mBMI, and mutation (Val30Met vs. Non-Val30Met), cardiac biomarkers were associated with surrogates of disease severity with BNP/NT-proBNP identified as an independent predictor of survival in ATTR.

  • Hellner, Erik
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för tillämpad utbildningsvetenskap.
    Sjöberg, Jakob
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för tillämpad utbildningsvetenskap.
    Vill du vara med?: En studie om fritidslärares planering och genomförande av idrott och fysiska aktiviteter i fritidshemsverksamhet2017Independent thesis Basic level (professional degree), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Den här studien har undersökt hur fritidslärare tolkar och använder läroplanen vid planering av idrott och andra fysiska aktiviteter i fritidshemmet. Studien tar även upp vilka utgångspunkter som fritidslärare använder sig av vid planering av idrott och andra fysiska aktiviteter i fritidshemsverksamheten. Syftet med studien är att synliggöra hur fritidslärare tolkar och använder läroplanen vid planering av idrott och andra fysiska aktiviteter både inomhus och utomhus i fritidshemmet. Syftet är vidare att belysa och analysera hur planeringen genomförs i den praktiska verksamheten. Resultatet i den här studien visar på att fritidslärare lägger mycket fokus på elevernas inflytande, intressen, kunskaper samt behov. De har även målen från läroplanen i bakhuvudet både vid planeringar samt i genomförande av aktiviteter i verksamheten. Resultatet visar även att fritidslärare jobbar mycket utifrån de olika ramfaktore roch förutsättningar som de har. Samtliga fritidslärare som vi har intervjuat som grund för dethär arbetet nämner flera utgångspunkter vid planeringsarbetet. Dessa behandlar många olikaaspekter av planeringsarbetet som till exempel rörelseglädje, inspiration eller ramfaktorer sompersonalstyrkan. De olika fritidshemmen som vi besökt ser olika ut men innehåller också många likheter när det kommer till utemiljön.

  • Westman, Anna
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    Sandström, Frida
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    Mazetti-Nissen, Ebba
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    Gränslöst arbete: En studie om kommunikationsteknikens påverkan på den psykosociala arbetsmiljön2017Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [en]

    Today the adoption and use of communication technology has broken down workplace boundaries and the dynamics of those, in specific regards to time and place. Through the integration of information technology, a new shape of work environment has been created. Technology makes it possible to work flexibly, independently and in a boundless digital environment, regardless of where one is located. This newly altered working environment presents new opportunities and challenges for both employees and their employers. This study aimed to create a deeper understanding of what the term boundless work implies and the effects it has on the psychosocial work environment. Through this study we also explore the perception of a sense of boundlessness within a consultant profession, along with employers’ awareness concerning this boundlessness within the work environment. This study used a qualitative research method, conducted through interviews to gather the data for this thesis. Our study indicates that access to communication technology contributes to the absence of boundaries in the workplace, in terms of availability and is a strong indication as to why employees are working beyond ordinary working hours and into their leisure time. In our recommendations section we argue that it is of importance to pay more attention to boundaries in work environments, as to better support employees’ time of recuperation away from work. We believe that the psychosocial environment of a workplace should be prioritized and that sustainable consultants make for profitable organizations. 

  • Yeung, Kelvin
    et al.
    Boija, Ann
    Karlsson, Edvin
    Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten). Division of CBRN Security and Defence, FOI-Swedish Defence Research Agency, Umeå, Sweden.
    Holmqvist, Per-Henrik
    Tstskis, Yonit
    Nisoli, Ilaria
    Yap, Damian
    Lorzadeh, Alireza
    Moksa, Michelle
    Hirst, Martin
    Aparicio, Samuel
    Fanto, Manolis
    Stenberg, Per
    Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten). Division of CBRN Security and Defence, FOI-Swedish Defence Research Agency, Umeå, Sweden.
    Mannervik, Mattias
    McNeill, Helen
    Atrophin controls developmental signaling pathways via interactions with Trithorax-like2017Inngår i: eLIFE, E-ISSN 2050-084X, Vol. 6, e23084Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Mutations in human Atrophin1, a transcriptional corepressor, cause dentatorubral-pallidoluysian atrophy, a neurodegenerative disease. Drosophila Atrophin (Atro) mutants display many phenotypes, including neurodegeneration, segmentation, patterning and planar polarity defects. Despite Atros critical role in development and disease, relatively little is known about Atros binding partners and downstream targets. We present the first genomic analysis of Atro using ChIP-seq against endogenous Atro. ChIP-seq identified 1300 potential direct targets of Atro including engrailed, and components of the Dpp and Notch signaling pathways. We show that Atro regulates Dpp and Notch signaling in larval imaginal discs, at least partially via regulation of thickveins and fringe. In addition, bioinformatics analyses, sequential ChIP and coimmunoprecipitation experiments reveal that Atro interacts with the Drosophila GAGA Factor, Trithorax-like (Trl), and they bind to the same loci simultaneously. Phenotypic analyses of Trl and Atro clones suggest that Atro is required to modulate the transcription activation by Trl in larval imaginal discs. Taken together, these data indicate that Atro is a major Trl cofactor that functions to moderate developmental gene transcription.

  • Rosenmüller, Mats H.
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
    Nilsson, Erik
    Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
    Lindberg, Fredrik
    Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
    Åberg, Sten-Olof
    Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
    Haapamaki, Markku M.
    Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
    Costs and quality of life of small-incision open cholecystectomy and laparoscopic cholecystectomy: an expertise-based randomised controlled trial2017Inngår i: BMC Gastroenterology, ISSN 1471-230X, E-ISSN 1471-230X, Vol. 17, 48Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Health care providers need solid evidence based data on cost differences between alternative surgical procedures for common surgical disorders. We aimed to compare small-incision open cholecystectomy (SIOC) and laparoscopic cholecystectomy (LC) concerning costs and health-related quality of life using data from an expertise-based randomised controlled trial. Methods: Patients scheduled for cholecystectomy were assigned to undergo LC or SIOC performed by surgeons in two different expert groups. Total costs were calculated in USD. Reusable instruments were assumed for the cost analysis. Quality of life was measured using the EuroQol 5-D 3-L (EQ 5-D-3L), at five postoperative time points and calculated to Area Under Curve (AUC) for 1 year postoperatively. Two hospitals participated in the trial, which included both emergency and elective surgery. Results: Of 477 patients that underwent a cholecystectomy during the study period, 355 (74.9%) were randomised and 323 analysed, 172 LC and 151 SIOC patients. Both direct and total costs were less for SIOC than for LC patients. The total costs were 5429 (4293-6932) USD for LC and 4636 (3905-5746) USD for SIOC, P = 0.001. The quality of life index did not differ between the LC and SIOC groups at any time. Median values (25th and 75th percentiles (p25-p75)) for AUC at 1 year were as follows: 349 (337-351) for LC and 349 (338-350) for SIOC. Conclusions: In this expertise-based randomised controlled trial LC was a more costly procedure and quality of life did not differ after SIOC and LC. (ClinicalTrials.gov Identifier: NCT00370344, August 30, 2006).

  • Persson, Emmy
    Umeå universitet, Humanistiska fakulteten, Institutionen för språkstudier.
    Att resa bortom textböckerna i en värld full av liv: Det upplevda värdet av studieresor utomlands i ämnet engelska på gymnasienivå.2017Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [en]

    The study aims to investigate how studies abroad in the English subject are made possible, motivated for, valued and evaluated. By using a qualitative method where three interviews with three students and two teachers were conducted the following results came to light: The results show that the municipality decides whether studies abroad will or will not be approved and financed. Furthermore, teachers and students work together with assignments before, during and after the trip which is followed by an evaluation. Finally, teachers’ and students’ attitudes and values towards studies abroad are both positive and negative. Both teachers and students can see an improvement in the English language where students develop a courage to use the English language, which in long term perspective leads to more use of the English language in the classroom, thus improved English. Teachers and students can also see an improvement in the students’ knowledge about English culture with a better understanding for what English culture is. Besides improvement connected to English as a subject, teachers and students can see that studies abroad lead to individual growth among the students.

  • Ivarsson, Andreas
    et al.
    Tranaeus, Ulrika
    Johnson, Urban
    Stenling, Andreas
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Negative psychological responses of injury and rehabilitation adherence effects on return to play in competitive athletes: a systematic review and meta-analysis2017Inngår i: Open Access Journal of Sports Medicine, ISSN 1179-1543, E-ISSN 1179-1543, Vol. 8, 27-32 s.Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Previous research offers evidence that psychological factors influence an injured athlete during the rehabilitation process. Our first objective was to conduct a systematic review and meta-analysis of the results from all published studies that examined the relationships among negative affective responses after sport injuries, rehabilitation adherence, and return to play (RTP). The second objective was to use a meta-analytic path analysis to investigate whether an indirect effect existed between negative affective responses and RTP through rehabilitation adherence. This literature review resulted in seven studies providing 14 effect sizes. The results from the meta-analysis showed that negative affective responses had a negative effect on successful RTP, whereas rehabilitation adherence had a positive effect on RTP. The results from the meta-analytic path analysis showed a weak and nonsignificant indirect effect of negative affective responses on RTP via rehabilitation adherence. These results underline the importance of providing supportive environments for injured athletes to increase the chances of successful RTP via a decrease in negative affective responses and increase in rehabilitation adherence.

  • Kjelgaard Mikkelsen, Carl Christian
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Högpresterande beräkningscentrum norr (HPC2N). Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för datavetenskap.
    Alastruey-Benede, Jesus
    Ibanez-Marin, Pablo
    Garcia Risueno, Pablo
    Accelerating Sparse Arithmetic in the Context of Newton's Method for Small Molecules with Bond Constraints2016Inngår i: Parallel Processing and Applied Mathematics, PPAM 2015, Part I / [ed] Wyrzykowski, R Deelman, E Dongarra, J Karczewski, K Kitowski, J Wiatr, K, Cham: Springer International Publishing Switzerland , 2016, 160-171 s.Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Molecular dynamics is used to study the time evolution of systems of atoms. It is common to constrain bond lengths in order to increase the time step of the simulation. Here we accelerate Newton's method for solving the constraint equations for a system consisting of many identical small molecules. Starting with a modular and generic base code using a sequential data layout, we apply three different optimization techniques. The compiled code approach is used to generate subroutines equivalent to a single step of Newton's method for a user specified molecule. Differing from the generic subroutines, these specific routines contain no loops and no indirect addressing. Interleaving the data describing different molecules generates vectorizable loops. Finally, we apply task fusion. The simultaneous application of all three techniques increases the speed of the base code by a factor of 15 for single precision calculations.

  • Enmark, Ulrika
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Pedagogiska institutionen.
    Stenberg, Teresa
    Umeå universitet, Samhällsvetenskapliga fakulteten, Pedagogiska institutionen.
    Jakten på det perfekta resultatet: En studie om hur man bedömer läsförmåga i åk 22017Independent thesis Basic level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [sv]

    Syftet med denna uppsats är att beskriva hur två skolor med likartade förutsättningar från samma skolområde, arbetat med resultaten av den obligatoriska kommunala screeningen i åk 2 vårterminen 2016. Studien avser också att klargöra hur kommunikationen angående screeningen mellan de olika nivåerna fungerar, till exempel mellan kommunens centrala tjänstemän och rektor, samt vidare ut till verksamheten. Avsikten är även att belysa hur den årliga screeningen påverkar specialpedagogers arbete, samt hur de olika skolornas arbete skiljer sig åt. Vi har undersökt detta ur ett sociokulturellt perspektiv och har använt intervjuer och dokumentstudier som datasamlingsmetod. Vi har intervjuat nio personer i olika positioner inom kommunen för att få en så heltäckande bild av processen som möjligt. Även ett stort antal informella samtal med personer som har beröring med ämnet har skett och har fördjupat förståelsen av det som undersökts. De dokument som studerats har varit instruktioner till genomförandet av screeningen (från kommunens intranät) samt statistik från Skolverkets databas SIRIS. Resultatet visade att arbetet med screeningen skiljer sig åt mellan de två skolorna, framför allt i efterarbetet med resultaten och påverkan på specialpedagogens arbete. Den ena skolan genomför ett arbete med träningstillfällen som sedan avslutas med ett nytt testtillfälle. Allt detta sker på uppdrag av rektor. På den andra skolan genomför ansvarig pedagog ett självständigt arbete med fokus på samarbete eftersom hen anser att det är vad gruppen främst behöver. Dessa skillnader i arbetssätt menar vi hör samman med olikheter i kontinuitet i personalsituationen samt ledningens inställning till resultat. Studien har också visat på brister i kommunikationen mellan de olika organisationsnivåerna och en tveksamhet till materialets utformning. Detta har vi tolkat som att screeningen som fenomen är ifrågasatt, utifrån aktuell läroplans synsätt och modern forskning kring bedömning.

  • Isles, Peter D. F.
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och geovetenskap. Rubenstein Ecosystem Science Laboratory, University of Vermont, Burlington, VT, USA; Rubenstein School of Environment and Natural Resources, University of Vermont, Burlington, VT, USA; Vermont EPSCoR, University of Vermont, Burlington, VT, USA.
    Xu, Yaoyang
    Stockwell, Jason D.
    Schroth, Andrew W.
    Climate-driven changes in energy and mass inputs systematically alter nutrient concentration and stoichiometry in deep and shallow regions of Lake Champlain2017Inngår i: Biogeochemistry, ISSN 0168-2563, E-ISSN 1573-515X, Vol. 133, nr 2, 201-217 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Concentrations of nitrogen (N) and phosphorus (P) in lakes may be differentially impacted by climate-driven changes in nutrient loading and by direct impacts of temperature and wind speed on internal nutrient cycling. Such changes may result in systematic shifts in lake N:P under future climate warming. We used 21 years of monitoring data to compare long-term and intra-annual trends in total N (TN), total P (TP) and TN:TP at 15 sites in Lake Champlain to concurrent measurements of watershed nutrient inputs and meteorological drivers. TN:TP declined sharply lake-wide, particularly in the past decade, yet the drivers of this trend varied based on site depth. In deep sites, declines were driven by changes in watershed loading of dissolved P and N and (in some cases) by decreases in hypolimnetic dissolved oxygen. In shallow sites, declines in TN:TP were primarily driven by long-term increases in temperature and decreases in wind speed, and exhibited systematic seasonal variability in TN:TP due to the timing of sediment P loading, N removal processes, and external nutrient inputs. We developed a conceptual model to explain the observed trends, and suggest that while climate drivers have affected nutrient dynamics in shallow and deep sites differently, both deep and shallow sites are likely to experience further declines in N:P and increases in cyanobacteria dominance if recent climate trends continue.

  • Alfredson, Håkan
    Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering. 2Institute of Sport, Exercise and Health, University College London Hospitals, London, UK.
    Low recurrence rate after mini surgery outside the tendon combined with short rehabilitation in patients with midportion Achilles tendinopathy2016Inngår i: Open Access Journal of Sports Medicine, ISSN 1179-1543, E-ISSN 1179-1543, Vol. 7, 51-54 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: There is a general opinion that a structured and specific rehabilitation is needed after treatment of midportion Achilles tendinopathy to minimize recurrence of the condition. There is sparse knowledge about the recurrence rates in large patient materials after specific treatments for midportion Achilles tendinopathy.

    Aim: This study aimed to investigate the recurrence rates in a large number of patients with chronic painful midportion Achilles tendinopathy that had been surgically treated with the ultrasound (US) and Doppler (DP)-guided mini-surgical scraping technique. Postoperatively, a relatively simple rehabilitation protocol, including a range of movement exercises and gradually increased walking and biking before allowing free activity, was used.

    Materials and methods: From a database, information about the recurrence rates after US + DP-guided mini-surgical scraping, performed by a single surgeon on 519 tendons with US + DP-verified chronic painful midportion Achilles tendinopathy, was obtained.

    Results: Recurrence of painful midportion Achilles tendinopathy was found in 26 of 519 (5%) operated tendons, 13 from women and 13 from men. In 13 tendons, a close by located plantaris tendon was extirpated during the reoperation.

    Conclusion: In this large material on patients treated with US + DP-guided mini-surgical scraping for midportion Achilles tendinopathy, there were few recurrences, although only a simple and nonspecific rehabilitation protocol was used.

  • Nordin, Pär
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap.
    Ahlberg, J.
    Johansson, H.
    Holmberg, Henrik
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Hafstrom, L.
    Risk factors for injuries associated with damage claims following groin hernia repair2017Inngår i: Hernia, ISSN 1265-4906, E-ISSN 1248-9204, Vol. 21, nr 2, 215-221 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Surgical repair of groin hernia should be carried out with minimal complication rates, and it is important to have regular quality control and accurate means of assessment. The Swedish healthcare system has a mutual insurance company (LA-F) that receives claims from patients who have suffered healthcare-related damage or malpractice. The Swedish Hernia Register (SHR) currently covers around 98% of all Swedish groin hernia operations. The aim of this study was to analyse damage claims following groin hernia repair surgery and link these with entries in the SHR, in order to identify risk factors and causes of injuries and malpractice associated with hernia repair. Data on all 48,574 groin hernia operations registered in the SHR between 2008 and 2010 were compared and linked with data on claims made to the Swedish National Patient Injury Insurance (LA-F). Of the 130 damage claims received by LA-F, 26 dealt with bleeding, 20 with testicular injury and 7 with intestinal lesions. Eighty (62%) of the complications were considered malpractice according to the Swedish Patient Injury Act. Acute and recurrent surgery, sutured repair and general anaesthesia were associated with a significantly increased risk for a damage claim independently the patients were compensated or not. Females filed claims in greater proportion than males. There was no significant difference in background factors between claims accepted by LA-F and compensated and those who were rejected compensation. Risk factors for filing a damage claim included acute surgery, operation for recurrence, sutured repair and general anaesthesia, whereas local anaesthesia reduced the risk.

  • Yin, Ge
    et al.
    Zhou, Yihui
    Strid, Anna
    Zheng, Ziye
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Department of Environmental Science and Analytical Chemistry, Stockholm University, 11418 Stockholm, Sweden.
    Bignert, Anders
    Ma, Taowu
    Athanassiadis, Ioannis
    Qiu, Yanling
    Spatial distribution and bioaccumulation of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in snails (Bellamya aeruginosa) and sediments from Taihu Lake area, China2017Inngår i: Environmental science and pollution research international, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 24, nr 8, 7740-7751 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Taihu Lake area is one of the densest metropolitan areas in the world including diverse industrial activity. In the present study, the snail (Bellamya aeruginosa) and sediment were collected from the Taihu Lake area to investigate the contamination status, congener pattern, spatial distribution, and bioaccumulation effect of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). The samples underwent liquid extraction, lipid removal by sulfuric acid, and acidic silica gel column, and subsequently analyzed by gas chromatography-electron capture detector (GC-ECD) and gas chromatography-mass spectrometry (GC-MS). Concentration of S22PCBs ranged between 90 and 680 ng g(-1) lipid weight in the snails and between 0.018 and 0.82 ng g(-1) dry weight in the sediments. Concentration of S24PBDEs varied from 25 to 200 ng g(-1) lipid weight in the snails and from 0.62 to 67 ng g(-1) dry weight in the sediments. The levels of PCBs and PBDEs observed were in the medium to low range compared with other studies in the world. CB-153 was the predominant PCB congener in both snails and sediments whereas BDE-209 showed a low bioavailability in the snails, even if it contributed up to 70% of S24PBDEs in the sediments. The spatial distribution showed that the highest concentration of PCBs and PBDEs were detected in samples from Zhushan Lake. East Taihu Lake and Dianshan Lake showed lower concentration of PCBs and PBDEs than the other sampling sites. Biota-sediment accumulation was found between snails and sediments of most of PCB and PBDE congeners except for the highly brominated BDEs (i.e., BDE-209). Therefore, sediment is suggested to be an appropriate matrix to monitor BDE-209 while aquatic species such as the snail could be good for monitoring of PCBs and lower brominated BDE congeners. No significant correlation (Spearman correlation test, two-tailed) of CB-153 (r = 0.54, p = 0.27) or BDE-47 (r = 0.60, p = 0.21) was found between snails and sediments.

  • Petursdottir, Greta
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    Nutti, Sandra
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    Att vara både här och där: En kvalitativ studie av hur unga vuxna upplever en växlande närvaro mellan en digital och analog värld2017Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [en]

    Smartphones and social media are a central part of everyday life for many young adults in the modern digital society. The development of digital devices has created opportunities for young adults to be present in a digital world through social media while at the same with people they meet face-to-face. Smartphones make the digital world portable, which give us access to a virtual network no matter where we are or what we are doing. This study aims to answer the question: How do young adults perceive a constant accessibility to a virtual world through social media in face-to-face meetings? The empirical data is based on interviews in focus groups along with hidden observations. Results from the study indicate that technology has become an essential part of young adults as they are never separated from their smartphones and regularly need to check new activities; whether they are alone or in the company of others. Social media is perceived as disruptive in face-to-face meetings, although still used frequently. It appears as though young adults are struggling to find a balance between a digital and analogue presence in a world where they can be both here and there simultaneously. 

  • Sperens, Maria
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Arbetsterapi.
    Hamberg, Katarina
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Allmänmedicin.
    Hariz, Gun-Marie
    Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Arbetsterapi. Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap.
    Are Patients Ready for "EARLYSTIM"?: Attitudes towards Deep Brain Stimulation among Female and Male Patients with Moderately Advanced Parkinson's Disease2017Inngår i: Parkinson's Disease, ISSN 2090-8083, E-ISSN 2042-0080, 1939831Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective. To explore, in female and male patients with medically treated, moderately advanced Parkinson's disease (PD), their knowledge and reasoning about Deep Brain Stimulation (DBS). Methods. 23 patients with PD (10 women), aged 46- 70, were interviewed at a mean of 8 years after diagnosis, with open-ended questions concerning their reflections and considerations about DBS. The interviews were transcribed verbatim and analysed according to the difference and similarity technique in Grounded Theory. Results. From the patients' narratives, the core category "Processing DBS: balancing symptoms, fears and hopes" was established. The patients were knowledgeable about DBS and expressed cautious and well considered attitudes towards its outcome but did not consider themselves ill enough to undergo DBS. They were aware of its potential side-effects. They considered DBS as the last option when oral medication is no longer sufficient. There was no difference between men and women in their reasoning and attitudes towards DBS. Conclusion. This study suggests that knowledge about the pros and cons of DBS exists among PD patients and that they have a cautious attitude towards DBS. Our patients did not seem to endorse an earlier implementation of DBS, and they considered that it should be the last resort when really needed.

  • Lundberg, Oscar
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    Ekman, Ludvig
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    Varför används inte det nya IT-stödet?: En kvalitativ studie om mjuka kompetensens värdeskapande inom IT-relaterade organisationsförändringar2017Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [en]

    Throughout time organizations have adapted and implemented different technological solutions to streamline their operation. With the adaption of new technology, employees will have to change their current routines. This readjustment is challenging for organizations because of people’s dislike towards changes. Studies in recent years within organizational change has highlighted soft skills value in this situation. A consulting company in Scandinavia (IT-consulting firm AB) has recently invested in soft skills to manage organizational change. The aim of this study is to investigate how significant soft skills are within IT-related organizational changes, for IT-consulting firm AB and their customers. Our investigation was a qualitative case study involving six semi-structured interviews with employees on IT-consulting firm AB. The results showed that soft skills are hard to define but involves intrapersonal skills like flexibility, adaptation and communication. Soft skills are essential both for IT-consulting firm AB and its customers. Its value creation within IT-related organizational change is interconnected to human activity like relationship building and understanding human needs.

  • Jansson, Linn
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    Naréus, Lisa
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    En digital dashboard, kostar den mer än den smakar?: En kvalitativ studie om vilka effekter en digital dashboard kan ge på organisationer2017Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [en]

    Many organizations are digitizing their business systems, creating potential to furthermore develop their organizations to become even more efficient. Business Intelligence is a collective term for skills, techniques, applications and processes that can help organizations to better understand their business. One of many Business Intelligence tools is a digital dashboard. A dashboard can collect the hidden figures in the business system or present already knows Key Performance Indicator to an organization. This study is conducted to find out what positive changes a usage of a dashboard can give to an organization. Through interviews and literature studies we have compared and analysed the results. This study shows that if you succeed with an implementation of a dashboard you will find benefits like better awareness, better agency and you will find that the organization will become more results orientated than before. They are all positive effects that a usage of a dashboard can give.

  • Disputas: 2017-06-16 13:00 Hörsal E, humansithuset, Umeå
    Lundmark, Mikael
    Umeå universitet, Humanistiska fakulteten, Institutionen för idé- och samhällsstudier.
    Religiositet och coping: religionspsykologiska studier av kristna med cancer2017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    This thesis investigates the interdependence of religiosity and a life situation changed by cancer, focusing especially on the coping process. This implies analyses of a number of identified expressions of religiosity regarding prerequisites and functions in the coping process. In order to synthesize the results from the studies, the aim has been operationalized into three comprehensive research questions that were posed to each of the empirical studies of the thesis: 1) What are the functions of the analysed expressions of religiosity during the coping process? 2) What prerequisites for the influence of religiosity on the coping process can be identified?  3) How is religiosity influenced by a life situation changed by cancer? The empirical studies are presented in four separate articles. Each of the studies has its own specific research questions that are related to the comprehensive research questions. The method was qualitative and explorative. The research material was gathered with qualitative interviews of 20 Swedish informants of varying gender, age, congregational affiliation and diagnosis. The informants defined themselves as Christians and practised their Christian faith and had or had had a cancer disease. There is longitudinal data from half of the group. The theoretical framework was based on the coping theories developed by Kenneth Pargament and Ruard Ganzevoort and complemented by, among other things, the object-relations theoretical concept of transitional objects.

    The results show that most of the analysed expressions of religiosity function as a preserving coping method but some of them also function as a reconstructing coping method. In some cases, the expressions of religiosity also function as methods of attributing control, either to God or to the individual. Two main groups of prerequisites for the expressions of religiosity were identified in conjunction with the coping process: contextual and psychological. The former could in turn be divided into religious and medical contexts; the latter into several different kinds, such as perceptual psychological factors, the need to create and use transitional objects, locus of control, and personality traits. Reconstructing coping methods imply varying degrees of changes in the informants’ religiosity, both regarding the analysed expression of religiosity and other expressions of religiosity. In addition to gaining insights into the interdependence of religion and coping for Christians living with cancer, the study contributes to the development of the psychology of religion coping theory by adding to the theory: 1) suggested specifications to the current concepts of Pargament’s coping theory; 2) the concept coping tool; 3) the distinction between functional and relational regarding the concepts of coping mechanism and coping method; 4) the coping mechanism attributing, and 5) the distinction between unilateral and bilateral deferring coping styles. The results indicate that the coping process can include a creative element in the form of a search for, or creation of, functional coping methods and/or coping tools which enhance the functionality of the coping process.

  • Disputas: 2017-06-15 10:00 KB3A9, KBC, Umeå
    Maier, Dominique Béatrice
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för ekologi, miljö och geovetenskap.
    Combining limnology and paleolimnology: a refined understanding of environmental sediment signal formation in a varved lake2017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Paleoclimatic archives, such as lake sediments, extend our understanding of terrestrial and aquatic ecosystem dynamics in relation to climate variability beyond the period covered by instrumental data. In this context, annually laminated (i.e. varved) lake sediments are particularly valuable, as they offer high temporal resolution and undisturbed sediment. However, in order to extract reliable climate information from lake sediments, a careful calibration with the processes controlling the sediment formation is essential. This thesis combines limnological and paleolimnological data from a varved, boreal lake in northern Sweden (Nylandssjön, Nordingrå) collected over different time scales. The main aim of the thesis is to gain a more refined insight into which processes are reflected in the sedimentary diatom assemblage. More specifically, sequential sediment trap records were coupled with physical, chemical and biological lake monitoring and environmental data for comparison and validation with the varved sediment record. The main result of the thesis is that timing, succession and inter-annual variability of key limnological and environmental processes (e.g. ice-cover duration, lake over-turn or catchment run-off) are of major importance for the sedimentary diatom assemblage formation. Continuous monitoring of physico-chemical parameters over three consecutive years identified varying winter air temperature as a major factor influencing in-lake processes and hence the diatom record. Timing of lake over-turn and catchment run-off seemed to be the driver for monospecific diatom blooms, which are reflected in the annual sediment signal. The integrated annual diatom signal in the sediment was dominated by spring or autumn blooms, resulting either from a Cyclotella glomerata dominated spring bloom after relatively warm winter conditions, or a Asterionella formosa dominated autumn bloom after relatively cold winter conditions. The analysis of the diatom stratigraphy in the varved sediment over several decades corroborated the importance of climatic variables (late winter air temperature and NAO), even though the variables with the most predictive power for variance in the diatom data were associated with sediment composition (C, N and sedimentation rate) and pollution (Pb and Cu). Overall, the analysis of the drivers of inter-annual and decadal diatom assemblage fluctuations emphasizes the importance of winter air temperature, indicating that weather extremes may be disproportionately represented in annual sediment records in contrast to nutrient concentrations or sedimentation rate.

  • Harström, Hanna
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik.
    Elever i matematiksvårigheter2017Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [sv]

    När man talar om begreppet matematiksvårigheter så finns det många olika tolkningar. Syftetmed denna studie är att få mer kunskap om lärares syn på matematiksvårigheter, samt vilkaresurser som används i undervisningen för elever i matematiksvårigheter i årskurserna 4–6.I denna studie undersöks lärares olika föreställningar och erfarenheter avmatematiksvårigheter genom kvalitativa semistrukturerade intervjuer. Tillsammans medförfattares olika tolkningar av begreppet matematiksvårigheter söks en djupare förståelse förundervisning av elever i matematiksvårigheter. Resultatet visar hur lärare upptäcker elever imatematiksvårigheter samt hur undervisningen anpassas på bästa sätt för dessa elever. Trotslärares olika förutsättningar så tycks de göra ett gediget arbete för att erbjuda elever rätt stöd iundervisningen.

  • Edlund, Viktoria
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik.
    Blomberg, Ida
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik.
    Formativ bedömning i matematiki årskurs 4-6: En studie om matematiklärares användning av formativbedömning2017Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [sv]

    Tidigare forskning visar att formativ bedömning har en positiv effekt på elevers lärande ochutveckling, men på grund av att den svenska skolan blir mer resultatinriktad blir det svårare attanvända formativ bedömning. Syftet med vårt examensarbete är att ta reda på hur matematiklärarearbetar med formativ bedömning i undervisningen. Med hjälp av 72 enkätsvar och intervjuer med 5lärare har vi fått svar på våra frågor. Frågorna handlar om hur formativ bedömning används imatematikundervisningen i årskurs 4–6, och hur lärare motiveras genom self-determination theorytill att arbeta, eller inte arbeta, med formativ bedömning. Resultatet visar att formativ bedömninganvänds i stor utsträckning i matematikundervisningen, och att lärare drivs framför allt av en yttremotivation för att arbeta med formativ bedömning. Många olika arbetssätt för formativ bedömninganvänds av lärare i matematikundervisningen. Muntlig feedback är det arbetssätt som används av flestinformanter.

  • Helmerius, Markus
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik.
    Att räkna på rätt sätt: En studie om lärares erfarenheter av att arbeta med standardalgoritm och skriftlighuvudräkning i årskurserna 4-62017Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [sv]

    När elever i årskurserna F-3 och 4-6 gör beräkningar i addition och subtraktion, är detframförallt två metoder de använder sig av, standardalgoritm, även kallad uppställning, ochskriftlig huvudräkning. Enligt forskning finns det både för- och nackdelar med bådametoderna. I detta arbete kommer lärares tankar och upplevelser av att arbeta med dessa tvåmetoder att lyftas och synliggöras genom kvalitativa intervjuer. Syftet med arbetet är dels attundersöka för- och nackdelar med de två beräkningsmetoderna men också vilken kunskapssynsom ligger till grund för lärarnas lektioner i matematik. Arbetet har också synliggjort hur välförmågorna inom matematik utvecklas av de två olika metoderna. Det resultat som framkomvisade att lärarna helst arbetar med standardalgoritm och inte låter förmågorna påverka derasundervisning i lika stor utsträckning som de 4 F:en. Det visade sig dessutom att den skriftligahuvudräkningen i större utsträckning utvecklade de fem matematiska förmågorna.

  • Nordlund, Pernilla
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik.
    Att förstå biologins betydelse för samhället: En lärares arbete med samhällsfrågor i biologiklassrummet2017Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [sv]

    Samhällsfrågor med naturvetenskapligt innehåll, SNI, är en undervisningsform med en tvärvetenskaplig inriktning som visat sig vara utvecklande och motiverande för elever. Ämnesplanerna i de naturvetenskapliga ämnena i den svenska gymnasieskolan framhåller också ett innehåll som är i linje med SNI. Samtidigt uttrycker lärare osäkerhet kring implementeringen av sådan undervisning. Syftet med denna studie är att ge insyn i hur lärare arbetar med att integrera SNI i sin biologiundervisning. Denna fallstudie ger en inblick i hur en lärare planerar för hur biologin kan sättas i ett samhällsperspektiv och hur det sedan realiseras i klassrummet. En lärare och fem elever har intervjuats och svaren analyserats genom en innehållsanalys. Lärarens arbete i klassrummet skildras genom fem elevers beskrivningar av det. Resultaten visade att fullständig SNI-undervisning är svår att genomföra i biologin och att alternativ samhällsanknytning både är önskvärd och mer förekommande.

  • Ekström, André
    Umeå universitet, Humanistiska fakulteten, Institutionen för språkstudier.
    Grejen med grammatikkunskaper: En studie av synen på grammatikkunskaper i styrdokument och läromedel för gymnasieskolans svenskämne2017Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [en]

    This study investigates the view of grammar knowledge that appears in the steering documents and six textbooks for Swedish in upper secondary school. The research was carried out with the research questions “What view of grammar knowledge appears in the curriculum?”, and “What view of grammar knowledge appears in the textbooks?”. The study was conducted with a qualitative content analysis of applicable parts of the curriculum and relevant meta-texts and student activities from the textbooks. The results show that the steering documents and the textbooks to varying degrees differ with respect to various aspects of the concept view of grammar knowledge, compared with each other and within the different groups of materials. Moreover, the results illustrate that the steering documents, with their general expressions, allow a broader view of grammar than the view which each individual textbook offers. 

  • Glassér, Charlotte
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för tillämpad utbildningsvetenskap.
    Entreprenörskapets, Företagandets och det Innovativa tänkandets Läroplansdidaktik (EFID) i Gymnasieskolan: En fallstudie av Sveagymnasium2017Independent thesis Advanced level (professional degree), 10 poäng / 15 hpOppgave
    Abstract [sv]

    År 2010 fick Sverige en ny skollag för grund- och gymnasieskolan och år 2011 kom dess relaterade nya läroplaner. I styrdokumenten för gymnasieskolan formuleras och betonas starkt ”entreprenörskap, företagande och innovation”, som politiska utbildnings- och lärandemål, vilka ska genomsyra alla utbildningsår och ämnen. Syftet med denna studie är att bredda och fördjupa forskningen och kunskapen om hur läroplanen för gymnasiet 2011 transformerats och realiserats, vad avser utbildning och didaktiska praktiker i ”entreprenörskap, företagande och innovativt tänkande” (EFI Lgy 2011). Med en abduktiv, och hermeneutisk forskningsdesign och fallbeskrivning som metodansats kartläggs, analyseras och beskrivs hur skolledningen och kollegiet på den utvalda skolan ”Sveagymnasium”, och dess erbjudna treåriga högskoleförberedande utbildningsprogram, har transformerat och realiserat läroplanens direktiv om utbildning och lärande i EFI Lgy2011 under perioden 2012–2016. Studiens huvudsakliga bidrag är fallbeskrivningen av Entreprenörskapets, Företagandets och det Innovativa tänkandets läroplansdidaktik (EFID) på Sveagymnasium. Fallbeskrivningen förmedlar förståelsen av en skola där det föreligger formell och fastställd samordning mellan lärandemålen i entreprenörskap, företagande och innovativt tänkande (EFI Lgy 2011), relaterad schemabunden- och ämnesintegrerad undervisning, bedömning och betygssättning. Detta är den empiriska grunden för deninitierade teoribildningen och forskningen om Entreprenörskapets, Företagandets och det Innovativa tänkandets Didaktik (EFID Lgy 2011). Fallstudien kan även användas som pedagogiskt redskap i utbildande och skolutvecklande syfte. Studien avser främst att bidra till den empiriska, läroplansdidaktiska, forskningen och dess teoribildning med en sociokulturell och redskapsmedierad betraktelselins

  • Disputas: 2017-06-13 13:00 N360, Umeå
    Areljung, Sofie
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik. Umeå universitet, Samhällsvetenskapliga fakulteten, Umeå centrum för genusstudier (UCGS).
    Utanför experimentlådan: kunskapsproduktion, tid och materia i förskolans naturvetenskapsundervisning2017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The aim of this thesis is to contribute knowledge on conditions for science teaching in preschool. While Swedish preschool practices commonly build on children’s subjective experiences, scientific knowledge production is often associated with objectivity and detachedness. Seen from that perspective, tensions may occur when the knowledge cultures of preschool and science meet, as when science teaching is implemented in preschool. This thesis seeks to explore issues that are crucial for teachers to negotiate when they implement science teaching in preschool.

    The thesis includes five articles that build on empirical data in the form of teachers’ talk (interviews, focus group discussion, project meetings) and observation data from preschool practice. The data analyses draw on various theoretical perspectives, including communities of practice and feminist critique of science as well as theoretical concepts connected to framing and agential realism.

    The main result is that it is crucial, to teachers’ implementation of science teaching in preschool, that science content is open to children’s contributions. Further, the results show that teachers integrate several different forms of knowledge production when working with science content in practice. For example, observations and systematic investigations are combined with imagination and children’s bodily experiences. This goes against the presumed tensions between the knowledge cultures of preschool and science. However, tensions between the knowledge cultures are indicated by teachers’ unwillingness to interfere with children’s investigative processes or ideas about science content by relating children’s ideas to scientific explanatory models. Seen from a teacher’s perspective, it appears to be unproblematic to leave children’s ideas about science content unresolved, compared to leaving children’s ideas about social relations and other content unresolved.

    Drawing on the results, I discuss teaching beyond the limited material and temporal dimensions of the science box, which emerges as a metaphor when teachers describe a way of teaching that they are not comfortable with. Further, I suggest that the concept working theories, which addresses children’s tentative ideas about relations in their surrounding world, be introduced in preschool science teaching, to ease the perceived conflict between children’s ideas about science and scientific explanatory models.

  • Aronsson, Magnus
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    Jonsson, Sanna
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    Jacqueline, Wester
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    Värdet av ett innovationscenteri offentlig sektor: En explorativ fallstudie av Arbetsförmedlingens digitalainnovationscenter2017Independent thesis Basic level (degree of Bachelor), 180 hpOppgave
    Abstract [en]

    The conditions for organizations today has fundamentally changed as a result of

    digitalization and digital innovation processes has become a central part in an organization's

    continued work to handle changing requirements and needs. Arbetsförmedlingens

    Innovationscenter is a new department that has been established as a part of the authority’s

    journey towards digital renewal with the ambition to visualize digital opportunity for

    tomorrow's labour market. A knowledge gap has been identified concerning how a public

    organization through an innovation initiative manage the continuously increasing

    expectations for them to work innovative and digitally. To close this gap an explorative case

    study is conducted to study the role Innovationscenter plays in Arbetsförmedlingens work

    with digital innovation. A conceptual framework is then created based on research on value

    creation and innovation processes which is then used to study the empiricism. The study

    shows that Innovationscenters role is mainly one of external monitoring, organisational

    development and marketing. The conclusion is that Innovationscenter spends more time

    inspiring than innovating and argumentation is presented concerning the importance of

    creating the relevant structures to go from inspiration to innovation.

  • Rundqvist, Daniel
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    Jonsson, Olivia
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för informatik.
    I huvudet på en digital entreprenör: Faktorer som spelar in för att lyckas med en startup2017Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
  • Pettersson, Ellen
    et al.
    Moström, Erica
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik.
    Är det problem eleverna löser?: En innehållsanalys av läroböcker i matematik2017Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [sv]

    Matematikundervisningen styrs till stor del av läroböcker och för att säkerställa kvalitén hosdem krävs en kritisk inställning. Studiens syfte var att öka kunskapen om hur läroböcker imatematik utvecklar elevers problemlösningsförmåga. Med hjälp av tidigare forskningutformades kriterier för begreppet problemlösningsuppgift och utifrån dessa kriteriergenomfördes en innehållsanalys av läroböcker för att undersöka problemlösningsuppgiftersförekomst, placering och utformning. Vi fann att problemlösningsuppgifternas förekomstvarierade mellan olika läroböcker. Vår studie visade också att de flestaproblemlösningsuppgifter är placerade så att alla elever får räkna dem, ett resultat sommotsäger viss forskning. Tidigare forskning har påpekat att det bör ske en progression iutformningen av problemlösningsuppgifterna från årskurs fyra till sex, men vi fann ingatecken på att det sker i de undersökta läroböckerna. Vi jämförde även om och hurlärarhandledningarna ger stöd till problemlösningsundervisning. De undersöktalärarhandledningarna har till stor del liknande beskrivningar och undervisningsförslaggällande problemlösning.

  • Hökén, Jimmy
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik.
    Lönnbäck, Viktor
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik.
    Användning av digitala verktyg i matematikundervisning2017Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [sv]

    Datorer, mobiltelefoner och iPads är exempel på digitala verktyg som används dagligen i samhället och skolan är inget undantag. Tidigare forskning beskriver att attityder, normer och upplevelser hos den enskilda läraren har stor betydelse för valet av digitala verktyg. Syftet med vår studie är att öka kunskapen om förutsättningarna för lärarens användning av digitala verktyg i matematikundervisningen i årskurs 4-6. Vilka yttre och inre faktorer upplever läraren existerar? Hur beskriver och motiverar läraren sina val mellan traditionella eller digitala verktyg? För att svara på frågorna använde vi intervjuer som konstruerades med utgångspunkt från Theory of planned behavior. Vår studie indikerar att det är fler yttre än inre faktorer som påverkar lärarens användning av digitala verktyg, varav fler underlättar än hindrar användandet. Resultaten är komplexa och svårtolkade men vi drar slutsatsen att framtiden för användning av digitala verktyg i matematikundervisningen ser ljus ut.

  • Vikström, David
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för tillämpad utbildningsvetenskap.
    Social kompetens - en bristvara?: Fritidshemmets betydelse för elevernas utveckling av den sociala kompetensen2017Independent thesis Basic level (professional degree), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Syftet med detta arbete är att utöka kunskapen kring den så kallade Generationen Y eller Millennium generationen och hur deras förhållningssätt samt egenskaper påverkar deras barns sociala kompetens, elever som idag finns i våra fritidshem. Fokus i arbetet ligger på uppfattningen kring elevernas sociala kompetens och hur mycket de t.ex. påverkas av sociala medier samt hur personal vid fritidsverksamheten arbetar med social kompetens och elevernas självkänsla. Studien grundar sig på kvalitativa intervjuer med fritidspedagoger.Resultatet visar tendenser till att barn/elever har en större självständighet men samtidigt en lägre självkänsla. Studien visar också att fritidshemsverksamheten är medveten om detta och arbetar målmedvetet för att förstärka elevernas självkänsla och deras sociala kompetens. En viktig slutsats är att fritidshemmet spelar en stor betydelse för utvecklingen inom dessa områden.

  • Tidlund, Daniel
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för tillämpad utbildningsvetenskap.
    Lundin, Jonathan
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för tillämpad utbildningsvetenskap.
    "Var tycker ni det är bäst att man byggermed lego?": En studie om begreppet meningsfull fritid inom fritidshemmets verksamhet2017Independent thesis Basic level (professional degree), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Detta examensarbete syftar till att utöka förståelsen för vad begreppet meningsfull fritid kan innebära i fritidshemmets verksamhet. Vi valde detta område därför att vi upplever en oklarhet i hur begreppet meningsfull fritid kan tolkas och realiseras i fritidshemmets verksamhet. Materialet som ligger till grund för resultatet består av kvalitativa intervjuer med sex verksamma fritidslärare i tre kommuner i Sverige. Resultatet är analyserat med tematiskanalys och strukturerat utifrån de teman som synliggjordes i informanternas utsagor. Av studien framkommer att fritidslärarna anser att barns inflytande tenderar att påverka om de uppfattar sin tid på fritidshemmet som meningsfull. Vidare framkommer det att begreppet meningsfull fritid inte har någon entydig betydelse och kan därför tolkas olika vilket medför att fritidslärare också arbetar med detta på olika sätt. Alla informanter som vi intervjuat är dock överens om att en meningsfull fritid bör utformas utifrån barnens behov och intressen. Resultatet visar även att ramfaktorer begränsar och påverkar barnens möjlighet till en meningsfull fritid. Utifrån vårt arbete drar vi slutsatsen att barns inflytande och delaktighet är betydelsefullt för att de ska uppleva sin tid inom fritidshemmet som meningsfull.

  • Bäckström, Ida
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för tillämpad utbildningsvetenskap.
    Johansson, Sandra
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för tillämpad utbildningsvetenskap.
    Sker det något lärande i fritidshem?: En intervjustudie med vårdnadshavare angående deras synpå lärandet i fritidshemmet2017Independent thesis Basic level (professional degree), 10 poäng / 15 hpOppgave
    Abstract [sv]

    I detta examensarbete redovisas och diskuteras en intervjustudie med vårdnadshavare angående lärandet som sker på fritidshemmet. Studiens syfte är att fördjupa kunskapen om vårdnadshavarnas uppfattning av fritidshemmet, vad de tror att fritidshemmet har för uppdrag, vad och hur barnen lär sig på fritidshemmet och om vårdnadshavarna anser sig se skillnad på lärandet mellan skolan och fritidshemmet. Vi har genomfört åtta intervjuer med vårdnadshavare från olika delar av en kommun i norra delen av Sverige. Intervjuerna har genomförts i form av kvalitativa intervjuer och de svar vi har fått ligger till grund för vårt resultat. Resultatet av studien visar att vårdnadshavarna upplever att barnen lär sig många olika saker på fritidshemmet, som den sociala läran och vardagslärande samt att lärandet sker i stor variation. Informanterna i studien beskriver att det ser en skillnad mellan lärande i skola och på fritidshemmet. De menar att på fritidshemmet lär sig barnen på sina egna villkor, informellt lärande och under skoltid sker mer formellt lärande.

  • Disputas: 2017-06-15 13:30 Samhällsvetarhuset, Hörsal C
    Hästbacka, Rasmus
    Umeå universitet, Samhällsvetenskapliga fakulteten, Juridiska institutionen.
    Europeiska företagsråd i svenska koncerner: en rättsvetenskaplig studie av EWC-regleringens betydelse för arbetstagarinflytande och styrning av multinationella koncerner2017Licentiatavhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    The subject matter of this licentiate thesis concerns the two EU directives on European Works Councils. The analysis is confined to the Swedish implementation of these directives into Swedish law. The thesis defines the term "EWC regulation" to encompass both the Swedish levels of EWC legislation and the regulation of EWCs by EWC agreements themselves.

    The overall objective is to gain an increased understanding of the function of EWC regulation. This requires a normative analysis of both EU and national law as well as an empirical study of the application. The thesis includes a number of agreements on EWCs based on the Swedish legislation and their application in corporations based in Sweden. Three multinational corporations in the health care sector, financial sector and metal industry have been selected.

    The focus lies on the regulation's practical significance for worker influence and corporate governance. A distinction is made between rules on worker participation (in law) and worker influence (in practice). As a point of departure the author combines the theory of reflexive law with concepts borrowed from the fields of management studies and economic history. The methods used consist of doctrinal legal interpretation and semi-structured interviews.

    The key findings run as follows. The EWC regulation generates worker influence by enhancing the knowledge and unity of worker representatives. The regulation facilitate corporate governance by strengthening the legitimacy of management, improving the decision basis and channels of communication. The worker influence is, under proper circumstances, strong in issues such as reorganizations, reassignments, health and safety. The influence is weaker in situations of relocation, outsourcing across national borders and other forms of regime shopping.

  • Lindahl, Joakim
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik.
    Granqvist, Simon
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för naturvetenskapernas och matematikens didaktik.
    Läxor i matematikundervisningen förmotivation och progression: En kvalitativ studie om läxans roll och hur de följs upp av lärarepå mellanstadiet2017Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
  • Disputas: 2017-06-12 09:00 Hörsal D, Umeå
    D'Ascenzi, Flavio
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Atrial function and loading conditions in athletes2017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Intensive training is associated with hemodynamic changes that typically induce an enlargement of cardiac chamber. Despite LA dilatation in athletes has been interpreted as a benign adaptation, little evidence is available. The aim of this thesis is to demonstrate that LA size changes in response to alterations in loading conditions and to analyse atrial myocardial function in athletes through the application of novel echocardiographic techniques.

    We found that top-level athletes exhibit a dynamic morphological and functional LA remodelling, induced by training, with an increase in reservoir and conduit volumes, but stable active volume. Training causes an increase in biatrial volumes which is accompanied by normal filling pressures and stiffness. These changes in atrial morphology are not associated with respective electrical changes. Extending the evidence from adult athletes to children, we found that training-induced atrial remodelling can occur in the early phases of the sports career and is associated with a preserved biatrial function. Finally, in a meta-analysis study of the available evidence we demonstrated that atrial function and size are not affected by aging.

    In conclusions, athlete’s heart is characterized by a physiological biatrial enlargement. This adaptation occurs in close association with LV cavity enlargement, is dynamic and reversible. This increase in biatrial size is not intrinsically an expression of atrial dysfunction. Indeed, in athletes the atria are characterized by a preserved reservoir function, normal myocardial stiffness, and dynamic changes in response to different loading conditions.

  • Hernandez, Alison
    et al.
    Ruano, Ana Lorena
    Marchal, Bruno
    San Sebastián, Miguel
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Flores, Walter
    Engaging with complexity to improve the health of indigenous people: a call for the use of systems thinking to tackle health inequity2017Inngår i: International Journal for Equity in Health, ISSN 1475-9276, E-ISSN 1475-9276, Vol. 16, 26Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The 400 million indigenous people worldwide represent a wealth of linguistic and cultural diversity, as well as traditional knowledge and sustainable practices that are invaluable resources for human development. However, indigenous people remain on the margins of society in high, middle and low-income countries, and they bear a disproportionate burden of poverty, disease, and mortality compared to the general population. These inequalities have persisted, and in some countries have even worsened, despite the overall improvements in health indicators in relation to the 15-year push to meet the Millennium Development Goals. As we enter the Sustainable Development Goals (SDGs) era, there is growing consensus that efforts to achieve Universal Health Coverage (UHC) and promote sustainable development should be guided by the moral imperative to improve equity. To achieve this, we need to move beyond the reductionist tendency to frame indigenous health as a problem of poor health indicators to be solved through targeted service delivery tactics and move towards holistic, integrated approaches that address the causes of inequalities both inside and outside the health sector. To meet the challenge of engaging with the conditions underlying inequalities and promoting transformational change, equity-oriented research and practice in the field of indigenous health requires: engaging power, context-adapted strategies to improve service delivery, and mobilizing networks of collective action. The application of systems thinking approaches offers a pathway for the evolution of equity-oriented research and practice in collaborative, politically informed and mutually enhancing efforts to understand and transform the systems that generate and reproduce inequities in indigenous health. These approaches hold the potential to strengthen practice through the development of more nuanced, context-sensitive strategies for redressing power imbalances, reshaping the service delivery environment and fostering the dynamics of collective action for political reform.

  • Yen, Amy Ming-Fang
    et al.
    Wu, Wendy Yi-Ying
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper. Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
    Tabar, Laszlo
    Duffy, Stephen W.
    Smith, Robert A.
    Chen, Hsiu-Hsi
    Initiators and promoters for the occurrence of screen-detected breast cancer and the progression to clinically-detected interval breast cancer2017Inngår i: Journal of Epidemiology, ISSN 0917-5040, E-ISSN 1349-9092, Vol. 27, nr 3, 98-106 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The risk factors responsible for breast cancer have been well documented, but the roles of risk factors as initiators, causing the occurrence of screen-detected breast cancer, or promoters, responsible for the progression of the screen-detected to the clinically-detected breast cancer, have been scarcely evaluated.

    Methods: We used data from women in a cohort in Kopparberg (Dalarna), Sweden between 1977 and 2010. Conventional risk factors, breast density, and tumor-specific biomarkers are superimposed to the temporal course of the natural history of the disease.

    Results: The results show that older age at first full-term pregnancy, dense breast, and a family history of breast cancer increased the risk of entering the preclinical screen-detectable phase of breast cancer by 23%, 41%, and 89%, respectively. Overweight/obesity (body mass index >= 25 kg/m(2)) was a significant initiator (adjusted relative risk [aRR] 1.15; 95% confidence interval [CI], 0.99-1.33), but was inversely associated with the role of promoter (aRR 0.65; 95% CI, 0.51-0.82). Dense breast (aRR 1.46; 95% CI, 1.12 -1.91), triple-negative (aRR 2.07; 95% CI, 1.37-3.15), and Ki-67 positivity (aRR 1.66; 95% CI, 1.19-2.30) were statistically significant promoters. When the molecular biomarkers were considered collectively as one classification, the basal-like subtype was the most influential subtype on promoters (aRR 4.24; 95% CI, 2.56-7.02) compared with the Luminal A subtype.

    Discussion: We ascertained state-dependent covariates of initiators and promoters to classify the risk of the two-step progression of breast cancer. The results of the current study are useful for individually-tailored screening and personalized clinical surveillance of patients with breast cancer that was detected at an early stage.

  • Doublet, Vincent
    et al.
    Poeschl, Yvonne
    Gogol-Doering, Andreas
    Alaux, Cedric
    Annoscia, Desiderato
    Aurori, Christian
    Barribeau, Seth M.
    Bedoya-Reina, Oscar C.
    Brown, Mark J. F.
    Bull, James C.
    Flenniken, Michelle L.
    Galbraith, David A.
    Genersch, Elke
    Gisder, Sebastian
    Grosse, Ivo
    Holt, Holly L.
    Hultmark, Dan
    Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten).
    Lattorff, H. Michael G.
    Le Conte, Yves
    Manfredini, Fabio
    McMahon, Dino P.
    Moritz, Robin F. A.
    Nazzi, Francesco
    Nino, Elina L.
    Nowick, Katja
    van Rij, Ronald P.
    Paxton, Robert J.
    Grozinger, Christina M.
    Unity in defence: honeybee workers exhibit conserved molecular responses to diverse pathogens2017Inngår i: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 18, 207Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Organisms typically face infection by diverse pathogens, and hosts are thought to have developed specific responses to each type of pathogen they encounter. The advent of transcriptomics now makes it possible to test this hypothesis and compare host gene expression responses to multiple pathogens at a genome-wide scale. Here, we performed a meta-analysis of multiple published and new transcriptomes using a newly developed bioinformatics approach that filters genes based on their expression profile across datasets. Thereby, we identified common and unique molecular responses of a model host species, the honey bee (Apis mellifera), to its major pathogens and parasites: the Microsporidia Nosema apis and Nosema ceranae, RNA viruses, and the ectoparasitic mite Varroa destructor, which transmits viruses.

    Results: We identified a common suite of genes and conserved molecular pathways that respond to all investigated pathogens, a result that suggests a commonality in response mechanisms to diverse pathogens. We found that genes differentially expressed after infection exhibit a higher evolutionary rate than non-differentially expressed genes. Using our new bioinformatics approach, we unveiled additional pathogen-specific responses of honey bees; we found that apoptosis appeared to be an important response following microsporidian infection, while genes from the immune signalling pathways, Toll and Imd, were differentially expressed after Varroa/virus infection. Finally, we applied our bioinformatics approach and generated a gene co-expression network to identify highly connected (hub) genes that may represent important mediators and regulators of anti-pathogen responses.

    Conclusions: Our meta-analysis generated a comprehensive overview of the host metabolic and other biological processes that mediate interactions between insects and their pathogens. We identified key host genes and pathways that respond to phylogenetically diverse pathogens, representing an important source for future functional studies as well as offering new routes to identify or generate pathogen resilient honey bee stocks. The statistical and bioinformatics approaches that were developed for this study are broadly applicable to synthesize information across transcriptomic datasets. These approaches will likely have utility in addressing a variety of biological questions.

  • Poveda, Alaitz
    et al.
    Chen, Yan
    Brändström, Anders
    Umeå universitet, Samhällsvetenskapliga fakulteten, Enheten för demografi och åldrandeforskning (CEDAR).
    Engberg, Elisabeth
    Umeå universitet, Samhällsvetenskapliga fakulteten, Enheten för demografi och åldrandeforskning (CEDAR).
    Hallmans, Göran
    Umeå universitet, Medicinska fakulteten, Enheten för biobanksforskning.
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Enheten för biobanksforskning.
    Renström, Frida
    Umeå universitet, Medicinska fakulteten, Enheten för biobanksforskning. Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Clinical Research Centre, Lund University, Jan Waldenströms gata 35, Building 91, Skåne University Hospital, SE-20502 Malmö, Sweden.
    Kurbasic, Azra
    Franks, Paul W.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin. Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Clinical Research Centre, Lund University, Jan Waldenströms gata 35, Building 91, Skåne University Hospital, SE-20502 Malmö, Sweden; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
    The heritable basis of gene-environment interactions in cardiometabolic traits2017Inngår i: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 60, nr 3, 442-452 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aims/hypothesis Little is known about the heritable basis of gene-environment interactions in humans. We therefore screened multiple cardiometabolic traits to assess the probability that they are influenced by genotype-environment interactions.

    Methods Fourteen established environmental risk exposures and 11 cardiometabolic traits were analysed in the VIKING study, a cohort of 16,430 Swedish adults from 1682 extended pedigrees with available detailed genealogical, phenotypic and demographic information, using a maximum likelihood variance decomposition method in Sequential Oligogenic Linkage Analysis Routines software.

    Results All cardiometabolic traits had statistically significant heritability estimates, with narrow-sense heritabilities (h (2)) ranging from 24% to 47%. Genotype-environment interactions were detected for age and sex (for the majority of traits), physical activity (for triacylglycerols, 2 h glucose and diastolic BP), smoking (for weight), alcohol intake (for weight, BMI and 2 h glucose) and diet pattern (for weight, BMI, glycaemic traits and systolic BP). Genotype-age interactions for weight and systolic BP, genotype-sex interactions for BMI and triacylglycerols and genotype-alcohol intake interactions for weight remained significant after multiple test correction.

    Conclusion/hypothesis Age, sex and alcohol intake are likely to be major modifiers of genetic effects for a range of cardiometabolic traits. This information may prove valuable for studies that seek to identify specific loci that modify the effects of lifestyle in cardiometabolic disease.

  • Justice, Anne E
    et al.
    Winkler, Thomas W
    Feitosa, Mary F
    Graff, Misa
    Fisher, Virginia A
    Young, Kristin
    Barata, Llilda
    Deng, Xuan
    Czajkowski, Jacek
    Hadley, David
    Ngwa, Julius S
    Ahluwalia, Tarunveer S
    Chu, Audrey Y
    Heard-Costa, Nancy L
    Lim, Elise
    Perez, Jeremiah
    Eicher, John D
    Kutalik, Zoltan
    Xue, Luting
    Mahajan, Anubha
    Renström, Frida
    Umeå universitet, Medicinska fakulteten, Enheten för biobanksforskning.
    Wu, Joseph
    Qi, Qibin
    Ahmad, Shafqat
    Alfred, Tamuno
    Amin, Najaf
    Bielak, Lawrence F
    Bonnefond, Amelie
    Bragg, Jennifer
    Cadby, Gemma
    Chittani, Martina
    Coggeshall, Scott
    Corre, Tanguy
    Direk, Nese
    Eriksson, Joel
    Fischer, Krista
    Gorski, Mathias
    Neergaard Harder, Marie
    Horikoshi, Momoko
    Huang, Tao
    Huffman, Jennifer E
    Jackson, Anne U
    Justesen, Johanne Marie
    Kanoni, Stavroula
    Kinnunen, Leena
    Kleber, Marcus E
    Komulainen, Pirjo
    Kumari, Meena
    Lim, Unhee
    Luan, Jian'an
    Lyytikainen, Leo-Pekka
    Mangino, Massimo
    Manichaikul, Ani
    Marten, Jonathan
    Middelberg, Rita P S
    Muller-Nurasyid, Martina
    Navarro, Pau
    Perusse, Louis
    Pervjakova, Natalia
    Sarti, Cinzia
    Smith, Albert Vernon
    Smith, Jennifer A
    Stancakova, Alena
    Strawbridge, Rona J
    Stringham, Heather M
    Sung, Yun Ju
    Tanaka, Toshiko
    Teumer, Alexander
    Trompet, Stella
    van der Laan, Sander W
    van der Most, Peter J
    Van Vliet-Ostaptchouk, Jana V
    Vedantam, Sailaja L
    Verweij, Niek
    Vink, Jacqueline M
    Vitart, Veronique
    Wu, Ying
    Yengo, Loic
    Zhang, Weihua
    Hua Zhao, Jing
    Zimmermann, Martina E
    Zubair, Niha
    Abecasis, Goncalo R
    Adair, Linda S
    Afaq, Saima
    Afzal, Uzma
    Bakker, Stephan J L
    Bartz, Traci M
    Beilby, John
    Bergman, Richard N
    Bergmann, Sven
    Biffar, Reiner
    Blangero, John
    Boerwinkle, Eric
    Bonnycastle, Lori L
    Bottinger, Erwin
    Braga, Daniele
    Buckley, Brendan M
    Buyske, Steve
    Campbell, Harry
    Chambers, John C
    Collins, Francis S
    Curran, Joanne E
    de Borst, Gert J
    de Craen, Anton J M
    de Geus, Eco J C
    Dedoussis, George
    Delgado, Graciela E
    den Ruijter, Hester M
    Eiriksdottir, Gudny
    Eriksson, Anna L
    Esko, Tonu
    Faul, Jessica D
    Ford, Ian
    Forrester, Terrence
    Gertow, Karl
    Gigante, Bruna
    Glorioso, Nicola
    Gong, Jian
    Grallert, Harald
    Grammer, Tanja B
    Grarup, Niels
    Haitjema, Saskia
    Hallmans, Göran
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.
    Hamsten, Anders
    Hansen, Torben
    Harris, Tamara B
    Hartman, Catharina A
    Hassinen, Maija
    Hastie, Nicholas D
    Heath, Andrew C
    Hernandez, Dena
    Hindorff, Lucia
    Hocking, Lynne J
    Hollensted, Mette
    Holmen, Oddgeir L
    Homuth, Georg
    Jan Hottenga, Jouke
    Huang, Jie
    Hung, Joseph
    Hutri-Kahonen, Nina
    Ingelsson, Erik
    James, Alan L
    Jansson, John-Olov
    Jarvelin, Marjo-Riitta
    Jhun, Min A
    Jorgensen, Marit E
    Juonala, Markus
    Kahonen, Mika
    Karlsson, Magnus
    Koistinen, Heikki A
    Kolcic, Ivana
    Kolovou, Genovefa
    Kooperberg, Charles
    Kramer, Bernhard K
    Kuusisto, Johanna
    Kvaloy, Kirsti
    Lakka, Timo A
    Langenberg, Claudia
    Launer, Lenore J
    Leander, Karin
    Lee, Nanette R
    Lind, Lars
    Lindgren, Cecilia M
    Linneberg, Allan
    Lobbens, Stephane
    Loh, Marie
    Lorentzon, Mattias
    Luben, Robert
    Lubke, Gitta
    Ludolph-Donislawski, Anja
    Lupoli, Sara
    Madden, Pamela A F
    Mannikko, Reija
    Marques-Vidal, Pedro
    Martin, Nicholas G
    McKenzie, Colin A
    McKnight, Barbara
    Mellstrom, Dan
    Menni, Cristina
    Montgomery, Grant W
    Musk, Aw Bill
    Narisu, Narisu
    Nauck, Matthias
    Nolte, Ilja M
    Oldehinkel, Albertine J
    Olden, Matthias
    Ong, Ken K
    Padmanabhan, Sandosh
    Peyser, Patricia A
    Pisinger, Charlotta
    Porteous, David J
    Raitakari, Olli T
    Rankinen, Tuomo
    Rao, D C
    Rasmussen-Torvik, Laura J
    Rawal, Rajesh
    Rice, Treva
    Ridker, Paul M
    Rose, Lynda M
    Bien, Stephanie A
    Rudan, Igor
    Sanna, Serena
    Sarzynski, Mark A
    Sattar, Naveed
    Savonen, Kai
    Schlessinger, David
    Scholtens, Salome
    Schurmann, Claudia
    Scott, Robert A
    Sennblad, Bengt
    Siemelink, Marten A
    Silbernagel, Gunther
    Slagboom, P Eline
    Snieder, Harold
    Staessen, Jan A
    Stott, David J
    Swertz, Morris A
    Swift, Amy J
    Taylor, Kent D
    Tayo, Bamidele O
    Thorand, Barbara
    Thuillier, Dorothee
    Tuomilehto, Jaakko
    Uitterlinden, Andre G
    Vandenput, Liesbeth
    Vohl, Marie-Claude
    Volzke, Henry
    Vonk, Judith M
    Waeber, Gerard
    Waldenberger, Melanie
    Westendorp, R G J
    Wild, Sarah
    Willemsen, Gonneke
    Wolffenbuttel, Bruce H R
    Wong, Andrew
    Wright, Alan F
    Zhao, Wei
    Zillikens, M Carola
    Baldassarre, Damiano
    Balkau, Beverley
    Bandinelli, Stefania
    Boger, Carsten A
    Boomsma, Dorret I
    Bouchard, Claude
    Bruinenberg, Marcel
    Chasman, Daniel I
    Chen, Yii-DerIda
    Chines, Peter S
    Cooper, Richard S
    Cucca, Francesco
    Cusi, Daniele
    Faire, Ulf de
    Ferrucci, Luigi
    Franks, Paul W
    Froguel, Philippe
    Gordon-Larsen, Penny
    Grabe, Hans-Jorgen
    Gudnason, Vilmundur
    Haiman, Christopher A
    Hayward, Caroline
    Hveem, Kristian
    Johnson, Andrew D
    Wouter Jukema, J
    Kardia, Sharon L R
    Kivimaki, Mika
    Kooner, Jaspal S
    Kuh, Diana
    Laakso, Markku
    Lehtimaki, Terho
    Marchand, Loic Le
    Marz, Winfried
    McCarthy, Mark I
    Metspalu, Andres
    Morris, Andrew P
    Ohlsson, Claes
    Palmer, Lyle J
    Pasterkamp, Gerard
    Pedersen, Oluf
    Peters, Annette
    Peters, Ulrike
    Polasek, Ozren
    Psaty, Bruce M
    Qi, Lu
    Rauramaa, Rainer
    Smith, Blair H
    Sorensen, Thorkild I A
    Strauch, Konstantin
    Tiemeier, Henning
    Tremoli, Elena
    van der Harst, Pim
    Vestergaard, Henrik
    Vollenweider, Peter
    Wareham, Nicholas J
    Weir, David R
    Whitfield, John B
    Wilson, James F
    Tyrrell, Jessica
    Frayling, Timothy M
    Barroso, Ines
    Boehnke, Michael
    Deloukas, Panagiotis
    Fox, Caroline S
    Hirschhorn, Joel N
    Hunter, David J
    Spector, Tim D
    Strachan, David P
    van Duijn, Cornelia M
    Heid, Iris M
    Mohlke, Karen L
    Marchini, Jonathan
    Loos, Ruth J F
    Kilpelainen, Tuomas O
    Liu, Ching-Ti
    Borecki, Ingrid B
    North, Kari E
    Cupples, L Adrienne
    Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits2017Inngår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, 14977-14977 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.

  • Roy, Ananya
    et al.
    Attarha, Sanaz
    Weishaupt, Holger
    Edqvist, Per-Henrik
    Swartling, Fredrik J.
    Bergqvist, Michael
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper.
    Siebzehnrubl, Florian A.
    Smits, Anja
    Ponten, Fredrik
    Tchougounova, Elena
    Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression2017Inngår i: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 8, nr 15, 24815-24827 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Serglycin is an intracellular proteoglycan with a unique ability to adopt highly divergent structures by glycosylation with variable types of glycosaminoglycans (GAGs) when expressed by different cell types. Serglycin is overexpressed in aggressive cancers suggesting its protumorigenic role. In this study, we explored the expression of serglycin in human glioma and its correlation with survival and immune cell infiltration. We demonstrate that serglycin is expressed in glioma and that increased expression predicts poor survival of patients. Analysis of serglycin expression in a large cohort of low-and high-grade human glioma samples reveals that its expression is grade dependent and is positively correlated with mast cell (MC) infiltration. Moreover, serglycin expression in patient-derived glioma cells is significantly increased upon MC co-culture. This is also accompanied by increased expression of CXCL12, CXCL10, as well as markers of cancer progression, including CD44, ZEB1 and vimentin. In conclusion, these findings indicate the importance of infiltrating MCs in glioma by modulating signaling cascades involving serglycin, CD44 and ZEB1. The present investigation reveals serglycin as a potential prognostic marker for glioma and demonstrates an association with the extent of MC recruitment and glioma progression, uncovering potential future therapeutic opportunities for patients.

  • Kable, Mary E.
    et al.
    Hansen, Lori M.
    Styer, Cathy M.
    Deck, Samuel L.
    Rakhimova, Olena
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.
    Shevtsova, Anna
    Eaton, Kathryn A.
    Martin, Miriam E.
    Gideonsson, Pär
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.
    Borén, Thomas
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk kemi och biofysik.
    Solnick, Jay V.
    Host Determinants of Expression of the Helicobacter pylori BabA Adhesin2017Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 46499Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Expression of the Helicobacter pylori blood group antigen binding adhesin A (BabA) is more common in strains isolated from patients with peptic ulcer disease or gastric cancer, rather than asymptomatic colonization. Here we used mouse models to examine host determinants that affect H. pylori BabA expression. BabA expression was lost by phase variation as frequently in WT mice as in RAG2-/- mice that do not have functional B or T cells, and in MyD88-/-, TLR2-/- and TLR4-/- mice that are defective in toll like receptor signaling. The presence of other bacteria had no effect on BabA expression as shown by infection of germ free mice. Moreover, loss of BabA expression was not dependent on Le(b) expression or the capacity of BabA to bind Leb. Surprisingly, gender was the host determinant most associated with loss of BabA expression, which was maintained to a greater extent in male mice and was associated with greater bacterial load. These results suggest the possibility that loss of BabA expression is not driven by adaptive immunity or toll-like receptor signaling, and that BabA may have other, unrecognized functions in addition to serving as an adhesin that binds Le(b).

  • Hatje, Ann-Katrin
    Comments on the Session Crime, Morality and Social Stigmatization2000Inngår i: Sex, State and Society: Comparative Perspectives on the History of Sexuality / [ed] Lars-Göran Tedebrand, Umeå: Nyheternas tryckeri KB i Umeå , 2000, 403-407 s.Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Lennerhed, Lena
    Sex Reform in the 1930's and 1940's: RFSU, the Swedish Association for Sex Education2000Inngår i: Sex, State and Society: Comparative Perspectives on the History of Sexuality / [ed] Lars-Göran Tedebrand, Umeå: Nyheternas tryckeri KB i Umeå , 2000, 403-407 s.Kapittel i bok, del av antologi (Annet vitenskapelig)
  • Disputas: 2017-06-09 09:00 Bergasalen, byggnad 27, Norrlands universitetssjukhus, Umeå
    Brynolfsson, Patrik
    Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik.
    Applications of statistical methods in quantitative magnetic resonance imaging2017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Magnetic resonance imaging, MRI, offers a vast range of imaging methods that can be employed in the characterization of tumors. MRI is generally used in a qualitative way, where radiologists interpret the images for e.g. diagnosis, follow ups, or assessment of treatment response. In the past decade, there has been an increasing interest for quantitative imaging, which give repeatable measurements of the anatomy. Quantitative imaging allows for objective analysis of the images, which are grounded in physical properties of the underlying tissues. The aim of this thesis was to improve quantitative measurements of Dynamic contrast enhanced MRI (DCE-MRI), and the texture analysis of diffusion weighted MRI (DW-MRI).

    DCE-MRI measures perfusion, which is the delivery of blood, oxygen and nutrients to the tissues. The exam involves continuously imaging the region of interest, e.g. a tumor, while injecting a contrast agent (CA) in the blood stream. By analyzing how fast and how much CA leaks out into the tissues, the cell density and the permeability of the capillaries can be estimated. Tumors often have an irregular and broken vasculature, and DCE-MRI can aid in tumor grading or treatment assessment. One step is crucial when performing DCE-MRI analysis, the quantification of CA in the tissue. The CA concentration is difficult to measure accurately due to uncertainties in the imaging, properties of the CA, and physiology of the patient. Paper I, the possibility of using two aspects of the MRI data, phase and magnitude, for improved CA quantification, is explored. We found that the combination of phase and magnitude information improved the CA quantification in regions with high CA concentration, and was more advantageous for high field strength scanners.

    DW-MRI measures the diffusion of water in and between cells, which reflects the cell density and structure of the tissue. The structure of a tumor can give insights into the prognosis of the disease. Tumors are heterogeneous, both genetically and in the distribution of cells, and tumors with high intratumoral heterogeneity have poorer prognosis. This heterogeneity can be measured using texture analysis. In 1973, Haralick et al. presented a texture analysis method using a gray level co-occurrence matrix, GLCM, to gauge the spatial distribution of gray levels in the image. This method of assessing texture in images has been successfully applied in many areas of research, from satellite images to medical applications. Texture analysis in treatment outcome assessment is studied in Paper II, where we showed that texture can distinguish between groups of patients with different survival times, in images acquired prior to treatment start.

    However, this type of texture analysis is not inherently quantitative in the way it is calculated today. This was studied in Paper III, where we investigated how texture features were affected by five parameters related to image acquisition and pre-processing. We found that the texture feature values were dependent on the choice of these imaging and preprocessing parameters. In Paper IV, a novel method for calculating Haralick texture features was presented, which makes the texture features asymptotically invariant to the size of the GLCM. This method allows for comparison of textures between images that have been analyzed in different ways.

    In conclusion, the work in this thesis has been aimed at improving quantitative analysis of tumors using MRI and texture analysis.

  • Disputas: 2017-06-09 10:00 Hörsal D, Samhällsvetarhuset
    Fjellfeldt, Maria
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för socialt arbete.
    Choice as governance in community mental health services2017Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    In 2009, the Act on Freedom of Choice Systems (SFS 2008:962) wasestablished in Sweden, and this enabled municipalities to organise services aschoice models. This thesis describes and analyses the implementation of afreedom of choice system within community mental health services. Daycentre services were in focus, and a case study was conducted of a majormunicipality that sought to be a “world-class city” in regard to citizens’ choice.The experiences of policy makers, managers, professionals, and participantswere explored in interviews, and documents on a national, municipal, and citydistrict level, as well as homepages of providers of community mental healthservices, were all part of the study and were analysed using content-analysismethods.

    The results showed that the freedom of choice system aimed for two objectives– improvements at the individual level and financial efficiency. In practice,financial efficiency was experienced as the main objective. Increased varietyof services was aimed for by the competitive model, but such variety was notobserved. Instead, services tended to be more similar than specialised.Concerning new providers, they were characterised as committedprofessionals running companies with strained economies. Participantsaffected by the reform expressed anxiety and worries due to theunpredictability and uncertainty embedded in the competitive choice model.Choice within the system concerned where to go, whereas participantsemphasised a wish to be able to influence the choice aspects of who carriedout the service and how much time to attend the services.

    The conclusion was that the freedom of choice system was implemented as atechnology of governance to increase financial efficiency of services.Individual choice was not experienced as increased in any aspect except forthe choice of where to go. Instead, freedom of choice actually appeared todecrease due to standardisation and hierarchical structures. Aspects that werefound to be relevant when designing freedom of choice systems aiming toincrease individual freedom of choice were to address predictability andcontinuity, to address sustainable financial premises, to analyse the predictedimpact of administrative systems that are to be used, and to avoid the use of“hidden goals” in the policy-making process.