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  • Apine, Anete
    et al.
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Business Administration.
    Escobar Valdés, Francisco José
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Business Administration.
    Risk Management in Sustainable Projects in the Construction Industry: Cases of Swedish Companies2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Sustainable construction projects are expanding in the market and green codes andstandards are advancing giving the ground for development of technology and materialsapplied. With every new material and technology utilised in the field, also risks aregrowing. The importance of risk management in sustainable construction projects isthus increasing and more experience and expertise is needed. So, the purpose of thisthesis is to examine and gain deeper understanding of project related risks in sustainableconstruction projects in Swedish companies operating in built environment. It is crucialto gain knowledge of good practices within the industry to be able to propose furtherinvestigation of the subject that could improve the existing risk management andsustainable construction project goals.This thesis examines the existing theory of the risk management process and sustainableprojects by shedding light on the trends within the construction industry. The intentionof the thesis is to add value to the existing gap in the theory that suggests thatconstruction industry is exposed to more risks and uncertainty than perhaps otherindustries, and that introducing sustainability adds more uncertainties and risks. Thisphenomenon is claimed to be due to the lack of knowledge and experience in the areaand, thus, practitioners seek for new ways how to tackle the arising issues. This thesisattempts to display how Swedish companies who are working with green and highperformance buildings identify and deal with risks.Two Swedish companies operating in built environment were chosen in order toinvestigate different ways of dealing with risks and the trend of sustainability inconstruction. Those in charge of risk and sustainability within the companies wereinterviewed applying semi-structured interviews and additional information wasgathered through multiple sources, such as annual reports, web pages and otherdocuments. This thesis has exploratory and qualitative research design and appliesabductive approach for the purpose and the nature of phenomena.The findings showed the different tools how risk management is applied in thecompanies and how it is related to the risks faced in green building construction. Theresults showed the importance of tools applied tackling sustainable construction projectsthat companies have applied and added to their processes in order to manageuncertainties that could occur if these processes were not implemented. As regards thegeneralisability towards findings, there still could be added more companies and futureresearch could imply also maturity of the companies to make findings more precise.However, after consideration of the processes learnt from companies, the proposedmodel for achievement of successful sustainable construction projects can be followedand applied in other companies operating in this industry.

  • Trang, Phan Minh
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Weather and extreme heat in association to mental disorders: The case of Hanoi, Vietnam2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Background: Vietnam suffers consequences of global warming. There is limited data of therelationship between weather, extreme heat and potential mental health problems. It is thereforecrucial to study heat-related mental illnesses and to establish good solutions with relevantadaptations to global warming. The adaptation measures should give attention to people that live inareas facing annual extreme weather, and protecting health in general and more specifically mentalhealth of citizens. The study aimed to examine relationships between weather patterns, extremeheat or heatwaves, and mental disorders, and to investigate factors contributing to increasedvulnerability and susceptibility.

    Methods: The thesis includes a systematic review and a hospital-based study using data from theHanoi Mental Hospital for five years (2008 – 2012), with mental disorders diagnosed by ICD10(F00-99) to estimate the effects of weather variation, seasonality, increased temperatures, andheatwaves on hospital admissions for depression and other mental disorders. A negative binomialregression model accounting for yearly study period, time trends, and day of the week was used toanalyze the relationship between seasonality, heatwaves, and monthly and daily mental disorderhospitalizations.

    Results: Our findings showed (i) a general tendency for more admissions between May andDecember, with a seasonal bi-annual high between May-June and November-December, andelevated ambient temperature was significantly related to increasing admissions for depressivedisorders; (ii) the number of hospital cases for mental disorders increased in the summer seasonespecially in June, and two percent of cases emerged during elevated temperature of one degreeCelsius; and (iii) when compared with non-heatwave periods, heatwaves amounted to increasingrisks for admission for the whole group of mental disorders (F00-79), and admissions for mentaldisorders among residents in rural communities and in the elderly population increasedsignificantly during heatwaves.

    Conclusion: There were associations between hospital admissions for depression and othermental disorders and seasonality, weather patterns, elevated temperatures, and heatwaves. Theassociations grew stronger with the length of the heatwaves and particularly the elderly appearedmore sensitive to seasonality, hot weather and heatwaves.

  • Rilinger, Holger
    Umeå University, Faculty of Social Sciences, Department of Law.
    Mineralbrytning inom Natura 2000-områden2017Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
  • Edgar, Atsuko
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
    Hur är kunskapen om infektionssjukdomar och behandling av dessa bland receptarier och apotekare på svenska apotek?2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Frosteblad, Gustav
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies.
    Handling och tro vid nattvardsbordet: En undersökning av nattvardssyner hos präster i Härnösand stift2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Honn, Marie
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
    Lindgren, Helena
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
    Bharath, Gurram Kumar
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
    Sjöstedt, Anders
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
    Lack of OxyR and KatG Results in Extreme Susceptibility of Francisella tularensis LVS to Oxidative Stress and Marked Attenuation In vivo2017In: Frontiers in Cellular and Infection Microbiology, E-ISSN 2235-2988, Vol. 7, 14Article in journal (Refereed)
    Abstract [en]

    Francisella tularensis is an intracellular bacterium and as such is expected to encounter a continuous attack by reactive oxygen species (ROS) in its intracellular habitat and efficiently coping with oxidative stress is therefore essential for its survival. The oxidative stress response system of F tularensis is complex and includes multiple antioxidant enzymes and pathways, including the transcriptional regulator OxyR and the H2O2-decomposing enzyme catalase, encoded by katG. The latter is regulated by OxyR. A deletion of either of these genes, however, does not severely compromise the virulence of F tularensis and we hypothesized that if the bacterium would be deficient of both catalase and OxyR, then the oxidative defense and virulence of F tularensis would become severely hampered. To test this hypothesis, we generated a double deletion mutant, Delta oxyR/Delta katG, of F tularensis LVS and compared its phenotype to the parental LVS strain and the corresponding single deletion mutants. In accordance with the hypothesis, Delta oxyR/Delta katG was distinctly more susceptible than Delta oxyR and Delta katG to H2O2, ONOO-, and O-2(-), moreover, it hardly grew in mouse-derived BMDM or in mice, whereas Delta katG and Delta oxyR grew as well as F tularensis LVS in BMDM and exhibited only slight attenuation in mice. Altogether, the results demonstrate the importance of catalase and OxyR for a robust oxidative stress defense system and that they act cooperatively. The lack of both functions render F tularensis severely crippled to handle oxidative stress and also much attenuated for intracellular growth and virulence.

  • Andersson Westman, Nina
    et al.
    Umeå University, Faculty of Medicine, Department of Nursing.
    Björnström, Anne
    Umeå University, Faculty of Medicine, Department of Nursing.
    Barns och ungdomars erfarenheter av att ha en förälder som drabbats av cancersjukdom: En litteraturstudie2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Titel: Barns och ungdomars erfarenheter av att ha en förälder som drabbats av cancersjukdom - en litteraturstudie.

    Bakgrund: Tusentals barn är anhöriga till cancersjuka föräldrar. Sjukdom hos föräldern påverkar barnets tillvaro både känslomässigt och praktiskt. Barn som anhöriga är sårbara på grund av sin beroendeställning till föräldern samt svårigheter att förstå det som händer och bakomliggande orsaker.

    Syfte: Syftet med denna uppsats är att beskriva barns och ungdomars erfarenheter av att ha en förälder som drabbats av cancersjukdom.

    Metod: En litteraturstudie genomfördes på 12 artiklar med kvalitativ ansats. Artiklarna granskades, analyserades och sammanställdes.

    Resultat: Resultatet presenterades i tre huvudkategorier och sammanlagt nio underkategorier. Huvudkategorierna innefattade: behov av kunskap och information, förändringar för hela familjen och en emotionellt svår och krävande situation.

    Konklusion: Sjuksköterskan bör tillämpa ett familjecentrerat förhållningssätt för att uppmärksamma barnens behov när deras vardag förändras. Information och stöd bör anpassas efter barnets utvecklingsnivå och individuella behov och önskemål. Mer forskning i ämnet skulle kunna förbättra bemötandet av barn som anhöriga. 

  • Pyhälä, Johanna
    et al.
    Umeå University, Faculty of Medicine, Department of Nursing.
    From, Linda
    Umeå University, Faculty of Medicine, Department of Nursing.
    Att identifiera det som sker bakom stängda dörrar: Vad hindrar sjukvårdspersonal från att identifiera kvinnor utsatta för våld i nära relation? En litteraturstudie2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Abstrakt

    Bakgrund: Våld i nära relation är ett globalt hälsoproblem och kränker kvinnans mänskliga rättigheter. I tidigare studier har kvinnor utsatta för våld i nära relation beskrivit svårigheter i att söka vård vilket kan ge allvarliga hälsokonsekvenser. Hälso- och sjukvården har därmed ett viktigt ansvar i att identifiera dessa kvinnor för att kunna erbjuda dem en god vård.

    Syfte: Att beskriva hinder för sjukvårdspersonal att identifiera kvinnor som utsätts för våld i nära relation.

    Metod: En litteraturstudie där åtta kvantitativa artiklar granskats, analyserats och sedan sammanställts.

    Resultat: Åtta hinder identifierades och sammanställdes i två huvudområden som innefattar: organisatoriska och personliga hinder. Resultat visade att brist på kunskap, brist på kliniska riktlinjer och bristande språkförståelse var associerat med en lägre screeningfrekvens.

    Konklusion: De rapporterade hindren för att screena kan leda till att kvinnor utsatta för våld i nära relation inte identifieras vilket utgör ett hot för deras hälsa. Hälso- och sjukvården skulle genom utbildning och förebyggande åtgärder kunna motverka att dessa hinder uppstår och därmed främja kvinnors hälsa.

    Nyckelord: Våld i nära relation, sjukvårdspersonal, hinder, identifiering, sjuksköterskor.

  • Dacke, Niklas
    et al.
    Umeå University, Faculty of Medicine, Department of Nursing.
    Malm, Malm
    Umeå University, Faculty of Medicine, Department of Nursing.
    Är det svårt att hålla mask eller?: Anestesisjuksköterskans erfarenheter av oväntat svåra luftvägar i samband med anestesi2016Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Managing the airway of a patient during anesthesia is one of anesthesia

    nurse's main tasks. When an unexpected difficult airway occurs, the high demands in

    terms of competence of the nurse anesthetist. Previous research has small extent

    focused on the nurse anesthetist experiences of this complex situation. It is therefore

    desirable to perform further studies on this subject, focusing on experience.

    Aim: The aim was to illustrate anesthetic nurses experiences of the unexpected

    difficult airway associated with anesthesia.

    Method: The study was conducting using qualitative approach. Data were collected

    through semi-structured interviews with ten anesthetic nurses employed in two

    different surgical departments in Sweden. The interviews were transcribed and

    analyzed by content analysis.

    Result: The analysis revealed four categories that describe anesthetic nurses

    experiences of the unexpected difficult airway associated with anesthesia; experiences

    of working under pressure, to work in teams, the importance of feeling safe in their

    professional capacity and the value reflection

    Conclusion: Anesthetic nurses shared experiences suggest a consensus that when

    these situations occur they requested more training together. This is partly to facilitate

    cooperation and also to take advantage of others' experiences and strategies to solve

    similar situations in the future.

    Keywords: Nurse anesthetist, unexpected difficult airways, experiences, feelings.

  • Dong, Bo
    et al.
    Holm, Linus
    Umeå University, Faculty of Social Sciences, Department of Psychology.
    Bao, Min
    Cortical mechanisms for afterimage formation: evidence from interocular grouping2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 41101Article in journal (Refereed)
    Abstract [en]

    Whether the retinal process alone or retinal and cortical processes jointly determine afterimage (AI) formation has long been debated. Based on the retinal rebound responses, recent work proposes that afterimage signals are exclusively generated in the retina, although later modified by cortical mechanisms. We tested this notion with the method of "indirect proof". Each eye was presented with a 2-by-2 checkerboard of horizontal and vertical grating patches. Each corresponding patch of the two checkerboards was perpendicular to each other, which produces binocular rivalry, and can generate percepts ranging from complete interocular grouping to either monocular pattern. The monocular percepts became more frequent with higher contrast. Due to adaptation, the visual system is less sensitive during the AIs than during the inductions with AI-similar contrast. If the retina is the only origin of AIs, comparable contrast appearance would require stronger retinal signals in the AIs than in the inductions, thus leading to more frequent monocular percepts in the AIs than in the inductions. Surprisingly, subjects saw the fully coherent stripes significantly more often in AIs. Our results thus contradict the retinal generation notion, and suggest that in addition to the retina, cortex is directly involved in the generation of AI signals.

  • Hibar, Derrek P.
    et al.
    Adams, Hieab H. H.
    Jahanshad, Neda
    Chauhan, Ganesh
    Stein, Jason L.
    Hofer, Edith
    Renteria, Miguel E.
    Bis, Joshua C.
    Arias-Vasquez, Alejandro
    Ikram, M. Kamran
    Desrivieres, Sylvane
    Vernooij, Meike W.
    Abramovic, Lucija
    Alhusaini, Saud
    Amin, Najaf
    Andersson, Micael
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
    Arfanakis, Konstantinos
    Aribisala, Benjamin S.
    Armstrong, Nicola J.
    Athanasiu, Lavinia
    Axelsson, Tomas
    Beecham, Ashley H.
    Beiser, Alexa
    Bernard, Manon
    Blanton, Susan H.
    Bohlken, Marc M.
    Boks, Marco P.
    Bralten, Janita
    Brickman, Adam M.
    Carmichael, Owen
    Chakravarty, M. Mallar
    Chen, Qiang
    Ching, Christopher R. K.
    Chouraki, Vincent
    Cuellar-Partida, Gabriel
    Crivello, Fabrice
    Den Braber, Anouk
    Doan, Nhat Trung
    Ehrlich, Stefan
    Giddaluru, Sudheer
    Goldman, Aaron L.
    Gottesman, Rebecca F.
    Grimm, Oliver
    Griswold, Michael E.
    Guadalupe, Tulio
    Gutman, Boris A.
    Hass, Johanna
    Haukvik, Unn K.
    Hoehn, David
    Holmes, Avram J.
    Hoogman, Martine
    Janowitz, Deborah
    Jia, Tianye
    Jorgensen, Kjetil N.
    Karbalai, Nazanin
    Kasperaviciute, Dalia
    Kim, Sungeun
    Klein, Marieke
    Kraemer, Bernd
    Lee, Phil H.
    Liewald, David C. M.
    Lopez, Lorna M.
    Luciano, Michelle
    Macare, Christine
    Marquand, Andre F.
    Matarin, Mar
    Mather, Karen A.
    Mattheisen, Manuel
    McKay, David R.
    Milaneschi, Yuri
    Maniega, Susana Munoz
    Nho, Kwangsik
    Nugent, Allison C.
    Nyquist, Paul
    Loohuis, Loes M. Olde
    Oosterlaan, Jaap
    Papmeyer, Martina
    Pirpamer, Lukas
    Puetz, Benno
    Ramasamy, Adaikalavan
    Richards, Jennifer S.
    Risacher, Shannon L.
    Roiz-Santianez, Roberto
    Rommelse, Nanda
    Ropele, Stefan
    Rose, Emma J.
    Royle, Natalie A.
    Rundek, Tatjana
    Saemann, Philipp G.
    Saremi, Arvin
    Satizabal, Claudia L.
    Schmaal, Lianne
    Schork, Andrew J.
    Shen, Li
    Shin, Jean
    Shumskaya, Elena
    Smith, Albert V.
    Sprooten, Emma
    Strike, Lachlan T.
    Teumer, Alexander
    Tordesillas-Gutierrez, Diana
    Toro, Roberto
    Trabzuni, Daniah
    Trompet, Stella
    Vaidya, Dhananjay
    Van der Grond, Jeroen
    Van der Lee, Sven J.
    Van der Meer, Dennis
    Van Donkelaar, Marjolein M. J.
    Van Eijk, Kristel R.
    Van Erp, Theo G. M.
    Van Rooij, Daan
    Walton, Esther
    Westlye, Lars T.
    Whelan, Christopher D.
    Windham, Beverly G.
    Winkler, Anderson M.
    Wittfeld, Katharina
    Woldehawariat, Girma
    Wolf, Christiane
    Wolfers, Thomas
    Yanek, Lisa R.
    Yang, Jingyun
    Zijdenbos, Alex
    Zwiers, Marcel P.
    Agartz, Ingrid
    Almasy, Laura
    Ames, David
    Amouyel, Philippe
    Andreassen, Ole A.
    Arepalli, Sampath
    Assareh, Amelia A.
    Barral, Sandra
    Bastin, Mark E.
    Becker, Diane M.
    Becker, James T.
    Bennett, David A.
    Blangero, John
    van Bokhoven, Hans
    Boomsma, Dorret I.
    Brodaty, Henry
    Brouwer, Rachel M.
    Brunner, Han G.
    Buckner, Randy L.
    Buitelaar, Jan K.
    Bulayeva, Kazima B.
    Cahn, Wiepke
    Calhoun, Vince D.
    Cannon, Dara M.
    Cavalleri, Gianpiero L.
    Cheng, Ching-Yu
    Cichon, Sven
    Cookson, Mark R.
    Corvin, Aiden
    Crespo-Facorro, Benedicto
    Curran, Joanne E.
    Czisch, Michael
    Dale, Anders M.
    Davies, Gareth E.
    De Craen, Anton J. M.
    De Geus, Eco J. C.
    De Jager, Philip L.
    De Zubicaray, Greig I.
    Deary, Ian J.
    Debette, Stephanie
    DeCarli, Charles
    Delanty, Norman
    Depondt, Chantal
    DeStefano, Anita
    Dillman, Allissa
    Djurovic, Srdjan
    Donohoe, Gary
    Drevets, Wayne C.
    Duggirala, Ravi
    Dyer, Thomas D.
    Enzinger, Christian
    Erk, Susanne
    Espeseth, Thomas
    Fedko, Iryna O.
    Fernandez, Guillen
    Ferrucci, Luigi
    Fisher, Simon E.
    Fleischman, Debra A.
    Ford, Ian
    Fornage, Myriam
    Foroud, Tatiana M.
    Fox, Peter T.
    Francks, Clyde
    Fukunaga, Masaki
    Gibbs, J. Raphael
    Glahn, David C.
    Gollub, Randy L.
    Goring, Harald H. H.
    Green, Robert C.
    Gruber, Oliver
    Gudnason, Vilmundur
    Guelfi, Sebastian
    Haberg, Asta K.
    Hansell, Narelle K.
    Hardy, John
    Hartman, Catharina A.
    Hashimoto, Ryota
    Hegenscheid, Katrin
    Heinz, Andreas
    Le Hellard, Stephanie
    Hernandez, Dena G.
    Heslenfeld, Dirk J.
    Ho, Beng-Choon
    Hoekstra, Pieter J.
    Hoffmann, Wolfgang
    Hofman, Albert
    Holsboer, Florian
    Homuth, Georg
    Hosten, Norbert
    Hottenga, Jouke-Jan
    Huentelman, Matthew
    Pol, Hilleke E. Hulshoff
    Ikeda, Masashi
    Jack, Clifford R., Jr.
    Jenkinson, Mark
    Johnson, Robert
    Joensson, Erik G.
    Jukema, J. Wouter
    Kahn, Rene S.
    Kanai, Ryota
    Kloszewska, Iwona
    Knopman, David S.
    Kochunov, Peter
    Kwok, John B.
    Lawrie, Stephen M.
    Lemaitre, Herve
    Liu, Xinmin
    Longo, Dan L.
    Lopez, Oscar L.
    Lovestone, Simon
    Martinez, Oliver
    Martinot, Jean-Luc
    Mattay, Venkata S.
    McDonald, Colm
    McIntosh, Andrew M.
    McMahon, Francis J.
    McMahon, Katie L.
    Mecocci, Patrizia
    Melle, Ingrid
    Meyer-Lindenberg, Andreas
    Mohnke, Sebastian
    Montgomery, Grant W.
    Morris, Derek W.
    Mosley, Thomas H.
    Muhleisen, Thomas W.
    Mueller-Myhsok, Bertram
    Nalls, Michael A.
    Nauck, Matthias
    Nichols, Thomas E.
    Niessen, Wiro J.
    Nothen, Markus M.
    Nyberg, Lars
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
    Ohi, Kazutaka
    Olvera, Rene L.
    Ophoff, Roel A.
    Pandolfo, Massimo
    Paus, Tomas
    Pausova, Zdenka
    Penninx, Brenda W. J. H.
    Pike, G. Bruce
    Potkin, Steven G.
    Psaty, Bruce M.
    Reppermund, Simone
    Rietschel, Marcella
    Roffman, Joshua L.
    Romanczuk-Seiferth, Nina
    Rotter, Jerome I.
    Ryten, Mina
    Sacco, Ralph L.
    Sachdev, Perminder S.
    Saykin, Andrew J.
    Schmidt, Reinhold
    Schmidt, Helena
    Schofield, Peter R.
    Sigursson, Sigurdur
    Simmons, Andrew
    Singleton, Andrew
    Sisodiya, Sanjay M.
    Smith, Colin
    Smoller, Jordan W.
    Soininen, Hilkka
    Steen, Vidar M.
    Stott, David J.
    Sussmann, Jessika E.
    Thalamuthu, Anbupalam
    Toga, Arthur W.
    Traynor, Bryan J.
    Troncoso, Juan
    Tsolaki, Magda
    Tzourio, Christophe
    Uitterlinden, Andre G.
    Hernandez, Maria C. Valdes
    Van der Brug, Marcel
    van der Lugt, Aad
    van der Wee, Nic J. A.
    Van Haren, Neeltje E. M.
    van't Ent, Dennis
    Van Tol, Marie-Jose
    Vardarajan, Badri N.
    Vellas, Bruno
    Veltman, Dick J.
    Voelzke, Henry
    Walter, Henrik
    Wardlaw, Joanna M.
    Wassink, Thomas H.
    Weale, Michael E.
    Weinberger, Daniel R.
    Weiner, Michael W.
    Wen, Wei
    Westman, Eric
    White, Tonya
    Wong, Tien Y.
    Wright, Clinton B.
    Zielke, Ronald H.
    Zonderman, Alan B.
    Martin, Nicholas G.
    Van Duijn, Cornelia M.
    Wright, Margaret J.
    Longstreth, W. T.
    Schumann, Gunter
    Grabe, Hans J.
    Franke, Barbara
    Launer, Lenore J.
    Medland, Sarah E.
    Seshadri, Sudha
    Thompson, Paul M.
    Ikram, M. Arfan
    Novel genetic loci associated with hippocampal volume2017In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, 13624Article in journal (Refereed)
    Abstract [en]

    The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

  • Timby, Niklas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
    Domellöf, Magnus
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
    Lif Holgerson, Pernilla
    Umeå University, Faculty of Medicine, Department of Odontology.
    West, Christina E.
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
    Lonnerdal, Bo
    Hernell, Olle
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
    Johansson, Ingegerd
    Umeå University, Faculty of Medicine, Department of Odontology.
    Oral Microbiota in Infants Fed a Formula Supplemented with Bovine Milk Fat Globule Membranes: A Randomized Controlled Trial2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 1, e0169831Article in journal (Refereed)
    Abstract [en]

    Background In a recent study, supplementation of infant formula with milk fat globule membranes (MFGM) decreased the incidence of otitis media in infants <6 months of age. Objectives The aim of the present study was to characterize the oral microbiota in infants fed MFGM-supplemented formula and compare it to that of infants fed standard formula or breast milk.

    Methods In a prospective double-blinded randomized controlled trial, exclusively formula-fed infants <2 months of age were randomized to be fed experimental formula (EF, n = 80) with reduced energy and protein and supplemented with a bovine MFGM concentrate, or standard formula (SF, n = 80) until 6 months of age. A breast-fed reference (BFR, n = 80) group was also recruited. The oral microbiota was analyzed at 4 (n = 124) and 12 (n = 166) months of age using Illumina MiSeq multiplex sequencing and taxonomic resolution against the HOMD 16S rDNA database of oral bacteria.

    Results Species richness in the oral samples did not differ between the EF and SF groups, but partial least square modeling identified a few taxa that were significantly associated with being in either group, e.g. lower level of Moraxella catarrhalis in the EF group. Infants in the BFR group had significantly lower species richness at 4 months of age and their microbiota pattern differed markedly from the formula-fed groups.

    Conclusions Supplementation of infant formula with MFGM yielded moderate effects on the oral micro biome. Moraxella catarrhalis was less prevalent in infants fed EF than in those fed SF and may be associated with the decrease in otitis media seen in the same group.

  • Netzén Örn, Marcel
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Economics.
    Negative Interest Rate & the Level of Household Debt: A Vector Autoregressive approach in a European perspective.2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Ever since the big recession of the world economy 2007, the central banks in Europe have struggled to regain financial stability. Their goals have been hard to reach and 2014 The European Central bank (ECB) introduced negative interest rates for the first time in the world history. However, today, year 2016, many countries still have not been able to reach their inflation target. During this time with expansive monetary policies, many European Union (EU) members have faced rising level of household debts to GDP.

    This study focus on EU-members and uses a Vector Autoregressive method, Granger causality test and an impulse-response test to give a greater understanding about the association between the level of household debt and interest rate. Further, it aims to investigate if the negative interest rate has an impact on that association. However, our empirical results show that there is a significant negative association between the level of household debt and the interest rate in Austria, Belgium, Bulgaria, Finland, Germany, Italy, Poland, Romania, Slovakia, Spain and Sweden. Further, they show that there is a granger causality from the interest rate to the level of household debt for Belgium, Finland, Germany, Poland, Slovakia and Sweden. For all these countries, our findings show that a shock in the interest rate have a short-term effect on the level of household debt.

    Lastly, we found no statistical significant evidence for that the negative association between the interest rate and the level of household debt does increase when the interest rate is negative.

  • Barclay, Mikael
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies.
    The absolutist criteria of Roderick Firth's ideal observer theory2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Meta-ethical theories take a number of different ontological, epistemic and semantic positions. In 1952 Roderick Firth published the article “Ethical absolutism and the ideal observer”, in which he defends and shares his own version of a theory on the meaning of ethical expressions, referred to as the ideal observer theory (IOT).

    The IOT essentially suggests that the truth value of an ethical expression could in principle be determined by knowing the ethically significant reaction it would evoke on an ideal observer (IO), of certain ideal psychological characteristics, should such a being exist. These characteristics are being understood in terms of an ideal practice of justification for actions. For instance, we might hold that in order to be a competent moral judge, we must have sufficient knowledge of the circumstances which we are to assess, or that we are not somehow biased. Firth suggests that an ideal observer has the characteristics of omniscience to non-ethical facts, omnipercipience, disinterest, dispassion and consistency. The theory itself is described as being absolutist, dispositional, objectivist, relational and possibly empirical.

    The specific research question of this paper regards the theory’s ability to give a plausible and meaningful explanation as to the meaning of ethical expressions, while maintaining its absolutist characteristic.

    The presented conclusion holds that: (i) the ethically significant reaction of IOs cannot be conflicting, (ii) that knowing the characteristics of the IO is not in principle necessary for the form and validity of the theory, (iii) that such form presupposes actual IO characteristics based on an assumption about the human nature and (iv) that ‘IO’ designates a hypothetical reference through a circular definition. And that this, although perhaps not in principle refuting the theory, renders it without the ability to provide any real meaningful explanation regarding the meaning of ethical expressions. A dilemma suggested to be possibly addressed by the abandonment of the theory’s absolutist criteria.

  • Wedegren, Carina
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
    Novel biomarkers in Pulmonary Hypertension: The correlation between ADMA, SDMA, L-arginine and disease progression and kidney function2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Hjälmarö, Andreas
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies.
    Defending the Subjective Component of Susan Wolf's "Fitting Fulfillment View" About Meaning in Life2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In this essay, I intend to analyze and respond to criticism directed towards the subjective component of Susan Wolf’s Bi-partite “Fitting Fulfillment View”, criticism directed from Thaddeus Metz, Ben Bramble, and Aaron Smuts. Wolf offers a theory about meaning in life which considers both that the subject should find it meaningful and that the source of this meaningfulness should be objectively valuable. However, critics have argued that a subject’s attitude towards meaningfulness should not affect whether one’s life is meaningful or not. Out of the critics I found promising and responded to I did not find any that seriously threatened Wolf’s theory and, in some cases they even seem to misunderstand Wolf’s claim. In the final section, I raise a question for Wolf’s account that I believe would be interesting to pursue in a further study. 

  • Linder, Johanna
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies.
    Grepp om upplevelsen: En undersökning av Blocks och Shoemakers diskussion angående kvalias tillgänglighet för subjektet, givet argumentet om frånvarande kvalia2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Frelijj González, Camila
    et al.
    Umeå University, Faculty of Social Sciences, Department of Psychology.
    Hakola, Robin
    Umeå University, Faculty of Social Sciences, Department of Psychology.
    Nyblivna psykologers psykosociala arbetsmiljö: De tre första åren efter examen2016Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Långvariga sjukskrivningar på grund av maladaptiva stressreaktioner, är i Sverige påtagligt vanligare blandpsykologer än i den yrkesverksamma befolkningen i övrigt. Syftet med denna studie är att kartlägganyutexaminerade psykologers hälsa och psykosociala arbetsmiljö utefter en enkät som skickats ut under 2016.Urvalet består av 602 respondenter, varav 454 är kvinnor, 141 är män och fem vill inte kategorisera sig, medelålder31.6 år (SD = 5.2). Denna tvärsnittsstudie presenterar deskriptiv information, korrelationer, regressioner, envägsANOVA samt kvalitativ data. Resultaten visar att 44% av respondenterna tagit sig till arbetet trots att de bordesjukskrivit sig. Utbildningsdimensionerna psykologiskt arbete och professionell utveckling påverkarrespondenternas skattade egenförmåga. Diskrepansen mellan skalorna nuvarande arbete och idealt arbete visar sigi gruppen vara mindre i grupperna: män, respondenter över 40 år och för de som huvudsakligen arbetar medkonsultation. Av intresse är att närmare en femtedel av nyutexaminerade psykologer har dagliga tankar att lämnayrket. Detta diskuteras utefter empiri från andra yrkesgrupper och utefter både kvantitativ och kvalitativ data sominkommit i enkätundersökningen.

  • Gustafsson, Jonas
    Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics.
    Scheduling Meetings across Organizational Borders: Collaboration and Interoperability between Government Agencies and External partners2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Swedish agencies are obligated to collaborate in order to fulfil their respective missions. One of the largest agencies, The Social Insurance Agency, collaborates with several agencies, employers and care providers. Collaboration that needs synchronous dialogues andexchange of information, requires people to coordinate calendars, but since the organizations’ technical systems are separated, problems occur. The meeting organizers have to face the time-wasting problem of searching for suitable meeting occasions, without access to the calendars of their external meeting participants. Meetings across organizational borders are, therefore, difficult to arrange. This study has enlightened this problem, using methods for deeper understanding of the user’s point of view, searching for alternative solutions and with an experimental approach evaluated four different alternatives, all with their own unique pros and cons. One solution based on a WebDAV/CalDAV concept is recommended, due to its potentials. It is superior to the other alternatives, because of its strength in functionality. Moreover, it has great potential to develop into a broader collaboration service, offering a digital work space with functions for document sharing, discussion boards etc.

  • Sundlöf, Louise
    Umeå University, Faculty of Social Sciences, Department of Political Science.
    Moment 22: Våld eller kränkningar mot lärare från elever – en kvalitativ studie som belyser detta outforskade samhällsproblem.2016Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Skolverket har genomfört en undersökning tillsammans med 1566 lärare, där resultatet visade att var femte lärare säger sig ha utsatts för hot, kränkningar eller våld på̊ sin arbetsplats under de senaste åren. Det vanligaste förekommande är att läraren blir utsatt av hot, kränkningar eller våld av en elev i en skolmiljö̈ (Skolverket, 2015, 74). Idag är lärarnas utsatthet ett outforskat område och det finns en viss otydlighet om hur man ska bemöta detta i skolorna.

    Uppsatsens syfte är att beskriva samt att skapa en förståelse hur skolan agerar när en våldshandling eller kränkning har utförts från en elev mot en lärare och se om de har använt sig av någon typ av åtgärdsprogram i samband med händelsen. För att besvara detta har studien utgått från följande frågeställningar:

    • Hur har skolledningen inom skolan agerat efter att en våldshandling eller en kränkning har skett mot en lärare av en elev?

    • Vilka typer, om några, av åtgärdsprogrammen har använts när en kränkning eller våld har förekommit mot en lärare av en elev?

    • Vilka typer, om några, av åtgärdsprogrammen bedöms som positiva för att säkra lärarnas arbetsmiljö̈?

    Studien är genomförd med en kvalitativ metod där sex semistrukturerade intervjuer med personal från en fristående grundskola mot äldre år har deltagit. Intervjurespondenterna är skolans rektor, biträdande rektor, skolkurator, personalansvarig och två̊ lärare. Resultatet från dessa intervjuer har diskuterats utifrån en teoretisk grund hur skolan har tolkat och problematiserat lärares utsatthet av kränkningar och våld från elever samt hur de har valt att agera genom åtgärdsprogram för att behandla detta som ett problem. Detta har huvudsakligen gjorts utifrån Carol Bachis WPR-teori och Lennart Lundqvist teori Förstå̊, kunna, vilja.

    Genom en diskussion har studien svarat på̊ de tre frågeställningarna, där svaret på̊ fråga ett är att det finns tydliga mönster på̊ hur skolan agerar när lärare utsätts för våld eller kränkningar från elever. Nämligen att skolan genomför en gruppdiskussion med de inblandade lärarna och elever tillsammans med rektor och eventuellt förälder/vårdnadshavare. I svaret på̊ fråga två̊ kan vi se att skolan har agerat utifrån ett informellt åtgärdsprogram som bygger på̊ att varje händelse är unik och där lösningen måste baseras på̊ en diskussion mellan samtliga inblandade, rektor och möjligtvis förälder/vårdnadshavare. I svaret på̊ fråga tre kan vi se att även om skolans ledning inte ser lärares utsatthet av kränkningar och våld från elever som ett betydande problem visar resultatet att en åtgärdsstruktur ändå följs, även om informellt, och kan därmed uppfattas som något positivt för lärarnas arbetsmiljö̈.

    Övrigt som framkom ur resultatet och diskussionen var att ett tydligt mönster framkom att representanter från skolledningen inte väljer att se problemet med lärare som utsätts av kränkningar eller våld från elever som ett tillräckligt stort problem för att lägga skolans resurser på̊ åtgärder mot detta. Resultatet av detta är att lärares arbetsmiljö̈ kan ses som en nedprioriterad del i skolledningens strategi. Ett annat tydligt mönster som framgår från resultat och diskussion är att skolan har en typ av åtgärdsprogram. Dock har detta inte uppmärksammats av skolledningen då det inte är formulerat i ett policy dokument.

    En av de tydligaste slutsatserna är dock att situationen gällande åtgärdsprogram kring detta problem blir ett så kallat ”moment 22”. Det vill säga att skolledningen inte vill sätta in ett åtgärdsprogram om inte problemet är större men ett åtgärdsprogram kan behövas for att uppmärksamma att problemet är större än vad skolledningen vet om idag. 

  • Wedebrand, Christoffer
    Umeå University, Faculty of Social Sciences, Department of Political Science.
    Förståelse vid krishantering2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Studiens syfte är tvåfaldigt. Dels är syftet att undersöka hur organisationers förståelse (i meningen deras lägesbild och situationsförståelse) och handlande tycks förhålla sig sinsemellan. Dels är syftet att undersöka hur organisatoriska skillnader tycks påverka förståelsen (återigen i meningen deras lägesbild och situationsförståelse). I båda fallen inom sammanhanget av samhällelig krishantering.

    Studiens forskningsfrågor besvaras genom en kombination av kvalitativa metoder. Det empiriska materialet utgörs av intervjuer med personal inom somliga av de räddningstjänster som inblandades i hanteringen av en omfattande skogsbrand på Gotland, våren 2016.

  • Eriksson, Markus
    Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics.
    Konstruktion av formatdelar: Konstruktion och materialanalys av formatdelar till APL2016Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This is a project that has been carried out in autumn 2016 for Bachelor of engineering in mechanical engineering at Umeå University. The work included 15 credits.  The aim of the project is to produce new parts for a machine that APL uses in its production. The machine in question fills bottles with liquid which is then sealed and sent on to the next station. APL makes use of several different sizes of these bottles but only have access to one size of format elements. This created a problem in that when you are working with the smaller bottles you are forced to put some extra material in where the format parts were too big.

     

    The materials that the old format parts consisted of was also an area that was investigated. This is because all parts are Heat-sterilized before they are used in the machine and during such treatment they are exposed to high temperatures. With the material used at the present time this heating process was causing the parts to lose their shape as they are not made for the temperature to which they are exposed.

    The purpose of this project is thus to produce 3d-drawings for the new format elements that are tailored to the bottles with smaller dimensions, as well as to investigate whether there are other materials that may be more suitable for the strain that parts are exposed to.

     

    To achieve this, i have examined the old parts and have taken the relevant measurements.

    The old measurements have been corrected and the new models have been drawn up in the CAD program SolidWorks. Since then, dimensioned drawings designed to serve as a manufacturing base have been made.  

    A study on material opportunities has also taken place, focusing on different plastic materials and the manufacturing processes that are relevant. Focus in terms of the materials was largely put on properties at high temperatures. Values are obtained from tables and calculations have been made, and together, this shows what material is best suited for the APLs purposes.

  • Mårtensson, Daniel
    Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Department of Applied Hydraulics.
    Principles of an automatic brewing machine: By using CodeSys with Raspberry Pi2017Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This project will give you a view from another side when it comes to control engineering and mechanical construction in brewing.

    This is a thesis project about principles for an automatic brewing machine. This project started off with prestudy of earlier research results in automatic brewing based on the Arduino platform.

    This project shows principles about mechanical construction and creating a control system by using inexpensive commercial products such as CodeSys and Raspberry Pi.

    The project report begins describing the mechanical construction, how it works and it shows how it looks. The mechanical construction is a tall scaffolding which is the chassis of the brewing machine.

    The history background about brewing is reviewed and the fundamental methods about brewing are described as well. The goal of this project is to present principals by using CodeSys and Raspberry Pi together. Notice that this is not a construction document. This document does not include production wiring diagrams or blueprints – only principles of wiring diagrams and figures of the machine, designed in a CAD software.

    This brewing machine includes a few different kind of control systems to automate the process. The processes are a hops container that can deliver a set of hops in a specific time, motorized whisks to distribute the heat, heat exchanger for cooling down, heating control system and a drain control system.

    The main focus in this project is the mechanical parts, the flow system, the control systems and a discussion about each sub system. Results shows a lot of pictures of the complete system with text that explain the pictures. What was good, what was bad and what could be done better.

  • Johansson, Cecilia
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Dahlqvist, Erik
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Andersson, Jonas
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Jansson, Jan-Håkan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Johansson, Lars
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Incidence, type of atrial fibrillation and risk factors for stroke: a population-based cohort study2017In: Clinical Epidemiology, ISSN 1179-1349, E-ISSN 1179-1349, Vol. 9, 53-62 p.Article in journal (Refereed)
    Abstract [en]

    Purpose: The aims of this study were to estimate the incidence of atrial fibrillation and atrial flutter (AF), to assess the presence of provoking factors and risk factors for stroke and systemic embolism, and to determine the type of AF in patients with first-diagnosed AF. Patients and methods: This cohort study was performed in northern Sweden between January 1, 2011 and December 31, 2012. Diagnosis registries were searched for the International Classification of Diseases-10 code for AF (I48) to identify cases of incident AF. All AF diagnoses were electrocardiogram-verified. Data pertaining to provoking factors, type of AF and presence of risk factors for stroke and systemic embolism according to the CHA(2)DS(2)-VASc score were obtained from medical records. Results: The incidence of AF in the entire population was 4.0 per 1,000 person-years. The incidence was 27.5 per 1,000 person-years in patients aged >= 80 years. A total of 21% of all patients had a provoking factor in association with the first-diagnosed episode of AF. The CHA(2)DS(2)-VASc score was 2 or higher in 81% of the patients. Permanent AF was the most common type of AF (29%). Conclusion: There was a considerable increase in the incidence of AF with age, and a provoking factor was found in one-fifth. The most common type of AF was permanent AF. Four in five patients had a CHA(2)DS(2)-VASc score of 2 or more.

  • Zarin, Rouien
    Umeå University, Faculty of Science and Technology, Umeå Institute of Design.
    Faster. Stronger. Better?: designing for enhanced engagement of extreme sports2017Doctoral thesis, monograph (Other academic)
    Abstract [en]

    The human body is capable of very rich and complex movements and gestures which we use in everyday life to manipulate, navigate and negotiate the world around us—it is our interface for human experience. However, as technology advances it simultaneously shrinks, moving closer to our bodies, intertwining with the many facets of our lives and positions itself between our experiences of the physical environments around us. When utilizing these technological systems in the context of intense sporting activities this competition for our focus leads to problematic scenarios—in the best case altering the aesthetic qualities of physical activity and in the worst case leaving us vulnerable to perilous situations. 

    This constructive design research thesis aims to understand how design may be used in relation to the body as part of an informative research approach to generate knowledge about how people actively engage with technology. This is deemed increasingly important as the advancements in technological connectivity and its corresponding trend in miniaturization create a pervasive effect that beckons closer examination and attention as these elements influence how we move. This is achieved by investigations conducted through studies in the area of extreme sports—specifically mountain biking and climbing activities— with the purpose of deepening understanding about human engagement with digital technologies situated within particular contexts. This research explores how the body’s movements can be considered a material to be worked with, designed and assessed in order to influence performance behaviour.

    Overall, the thesis undertakes a mixed methods approach to addressing interaction design issues within the context of movement. By advocating making as a generative activity, this research produces a series of artifacts drawing from notions of embodiment that is used to ‘tease out’ knowledge, which is then reflected upon and iterated. These corresponding artifacts embody and imbue designerly intention, subsequently raising pertinent questions of what it means to be connected in an ever evolving digital world, and how we can distinguish, address and begin to design for/with information realities relating to the natural and artificial.

    Ultimately the thesis offers three main contributions to designers and researchers: (1) the Stages of Performativity framework that serves to increase awareness of the temporal aspects when designing for activities (2) A proposed model of the makers prototyping process and its corresponding seduction loop phenomenon (3) a series of non-prescriptive artifacts intended to be aspirational such as the Blackbox, Heel hook, Morpheel, Griptile and Climbing Sleeve prototypes. These contributions could be of particular interest to those intent on utilizing a maker driven prototyping practice by primarily proposing a comprehensive account of the transactions occurred during my prototyping process that is conducive to heightening awareness and cognition towards athletes engaged in extreme sports. The hope is to inspire an active role in designing experiences that enhance or support physical activities rather than impeding them.

    In addition, this research approach advocates the unpacking or engagement with technological materials as a means for extending understanding and defining their functions in for the sake of employing them for thought provoking, prototyping endeavors to challenge complex and seemingly established systems while simultaneously providing a discourse in regards to the advancements of connected technologies towards a more humanizing experience.  

    Finally, it is suggested that the probing of alternate realities by means of constructive design exploration is an essential step towards sketching meaningful engagement when considering the role that we desire technology to play in our lives.

  • Björnstig, Johanna
    et al.
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
    Bylund, Per-Olof
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
    Björnstig, Ulf
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
    Vehicle-related injuries in and around a medium sized Swedish City - bicyclist injuries caused the heaviest burden on the medical sector2017In: Injury Epidemiology, ISSN 0176-3733, E-ISSN 2197-1714, Vol. 4, 4Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: A data acquisition from the medical sector may give one important view of the burden on the society caused by vehicle related injuries. The official police-reported statistics may only reflect a part of all vehicle-related injured seeking medical attention. The aim is to provide a comprehensive picture of the burden of vehicle related injuries on the medical sector (2013), and to compare with official police-reported statistics and the development year 2000-2013.

    METHODS: The data set includes 1085 injured from the Injury Data Base at Umeå University Hospital's catchment area with 148,500 inhabitants in 2013.

    RESULTS: Bicyclists were the most frequently injured (54%). One-third had non-minor (MAIS2+) injuries, and bicyclists accounted for 58% of the 1071 hospital bed days for all vehicle-related injuries. Car occupants represented 23% of all injured, and only 9% had MAIS2+ injuries. They accounted for 17% of the hospital bed days. Motorized two wheel vehicle riders represented 11% of the injured and 39% had MAIS2+ injuries and they occupied 11% of the hospital bed days. Of the 1085 medically treated persons, 767 were injured in public traffic areas, and, therefore, should be included in the official police statistics; however, only a third (232) of them were reported by the police. The annual injury rate had not changed during 2000-2013 for bicyclists, motor-cycle riders, pedestrians or snowmobile riders. However, for passenger car occupants a decrease was observed after 2008, and for mopedists the injury rate was halved after 2009 when a licensing regulation was introduced.

    CONCLUSION: The Swedish traffic injury reducing strategy Vision Zero, may have contributed to the reduction of injured car occupants and moped riders. The official police-reported statistics was a biased data source for vehicle related injuries and the total number medically treated was in total five times higher. Bicyclists caused the heaviest burden on the medical sector; consequently, they need to be prioritized in future safety work, as recently declared in the Government plan Vision Zero 2.0.

  • Patthey, Cedric
    et al.
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Tong, Yong Guang
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Tait, Christine Mary
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Wilson, Sara Ivy
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Evolution of the functionally conserved DCC gene in birds2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 42029Article in journal (Refereed)
    Abstract [en]

    Understanding the loss of conserved genes is critical for determining how phenotypic diversity is generated. Here we focus on the evolution of DCC, a gene that encodes a highly conserved neural guidance receptor. Disruption of DCC in animal models and humans results in major neurodevelopmental defects including commissural axon defects. Here we examine DCC evolution in birds, which is of particular interest as a major model system in neurodevelopmental research. We found the DCC containing locus was disrupted several times during evolution, resulting in both gene losses and faster evolution rate of salvaged genes. These data suggest that DCC had been lost independently twice during bird evolution, including in chicken and zebra finch, whereas it was preserved in many other closely related bird species, including ducks. Strikingly, we observed that commissural axon trajectory appeared similar regardless of whether DCC could be detected or not. We conclude that the DCC locus is susceptible to genomic instability leading to independent disruptions in different branches of birds and a significant influence on evolution rate. Overall, the phenomenon of loss or molecular evolution of a highly conserved gene without apparent phenotype change is of conceptual importance for understanding molecular evolution of key biological processes.

  • Svedmark, Maja
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies.
    Trälbunden vilja för frihet: En studie om frihetsbegreppet i Martin Luthers skrift Om den trälbundna viljan.2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Ronestjärna, Benjamin
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies.
    Att minnas det hörda: En närläsning av muntlig och skriftlig kommunikation i 5 Mos 6:4-92017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Hultdin, Joel
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies.
    För oss utgiven: En empirisk undersökning av nattvardssynen hos präster i Luleå stift2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • Lundberg, Otto
    Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
    GDP forecasting and nowcasting: Utilizing a system for averaging models to improve GDP predictions for six countries around the world2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This study was issued by Swedbank because they wanted too improve their GDP growth forecast capabilites.  A program was developed and tested on six countries; USA, Sweden, Germany, UK, Brazil and Norway.

    In this paper I investigate if I can reduce forecasting error for GDP growth by taking a smart average from a variety of models compared to both the best individual models and a random walk. I combine the forecasts from four model groups: Vector autoregression, principal component analysis, machine learning and random walk. The smart average is given by a system that give more weight to the predictions of models with a lower historical error. Different weighting schemas are explored; how far into the past should we look? How much should bad performance be punished?

    I show that for the six countries studied the smart average outperforms the single best model and that for five out of six countries it beats a random walk by at least 25%.

  • Ruud, Svein
    et al.
    Östman, Leif
    Orädd, Philip
    Umeå University.
    Energy savings for a wood based modular pre-fabricated facade refurbishment system compared to other measures2016In: Sustainable built environment Tallinn and Helsinki Conference SBE16: build green and renovate deep, 2016, 768-778 p.Conference paper (Refereed)
    Abstract [en]

    There is a need to focus on energy efficiency for the existing buildings, especially buildings erected before the energy crises in the seventies, as these buildings provide a massive potential for improvements in energy performance. The facades of these buildings are also facing an increased need for a face-lift. There are a large number of such facades in all these countries. One problem is that these buildings must be refurbished at low costs and with limited disturbance to the users/tenants. In this study we have investigated the energy efficiency of a modular pre-fabricated facade refurbishment system based on wood and compared it to two existing systems for on-site mounting of additional insulation. These existing alternatives require a lot of on-site works. Hence prefabricated solutions would, of course, offer advantages. There have been several attempts to develop such solutions in recent years but so far none of them have provided an acceptable solution. This approach is based on an alternative with small scale prefab elements with a simple assembly process. The energy analyses concentrate on thermal bridges and U-values, relating it to the total energy performance and compared to the current situation and comparable refurbishment methods. We have mainly focused on the wall structures but as a comparison also other energy saving measures has been investigated shortly. For the very common reference building the pre-fabricated solution is the third most effective energy measure. We have also conducted a study of the energy efficiency regulations in different Nordic countries in order to see what the current legal framework is, and tried to sort out how far it is possible to improve energy efficiency by means of improving the U-value of the exterior walls. The outcome is a verification of the energy efficiency of the chosen prefab structure as a solution for refurbishment. The advantages are to be found in the dry production process combined with a simple and fast assembly on site. Similarly, there are advantages in the reduced number of thermal bridges and in the potential for the use of recyclable materials. Another advantage is that it has an integrated air tightness that is mounted on the outside of the existing wall. This is part of a larger research project aiming at cost efficient and sustainable solutions for refurbishment of facades in a Nordic context. In the larger research project, we have also conducted a cost-benefit analyses and studied moisture conditions in order to see how far this solution might be feasible. The ultimate aim is to test a product and compare the findings from demo projects in the three countries Norway, Sweden and Finland.

  • Sandlund, Elisabeth
    Umeå University, Faculty of Arts, Department of language studies.
    Intensivläsning: En interventionsstudie med upprepad läsning av ord och text2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The aim of the study was to investigate if an intensive reading intervention based on decoding word and text through repeated reading could improve the students’ reading fluency and thereby their reading comprehension. Reading fluency can be defined as reading with suitable speed, good decoding and word recognition, by using prosody and showing understanding of what has been read. The method in the study was an experimental intervention combined with interviews with participating students. Eight students in grades 2 and 3 were included, and they were divided into two comparable groups, an intervention group and a control group. Pre- and post-test examined whether the intervention had effects on the students’ decoding and reading comprehension compared to the control students. The interviews explored how the students experienced the intervention and how they felt that the training affected their ability to read. The results showed that most of the students in the intervention-group improved their reading accuracy, which in turn may have affected their reading comprehension in a positive way. According to the interviews, the students experienced the activities mostly as meaningful and fun (with one negative thing, they missed class teaching) and they all think they have learned things that have been positive for their ability to read. In conclusion, this study proposes that an intensive reading intervention can be a good way for specialist teachers to assist students in their early reading development.

  • Nilsson, Christer
    et al.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Sarneel, Judith M.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences. Ecology & Biodiversity Group and Plant Ecophysiology Group, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
    Palm, Daniel
    Gardeström, Johanna
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Pilotto, Francesca
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Polvi, Lina E.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Lind, Lovisa
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Holmqvist, Daniel
    Lundqvist, Hans
    How do biota respond to additional physical restoration of restored streams?2017In: Ecosystems (New York. Print), ISSN 1432-9840, E-ISSN 1435-0629, Vol. 20, no 1, 144-162 p.Article in journal (Refereed)
    Abstract [en]

    Restoration of channelized streams by returning coarse sediment from stream edges to the wetted channel has become a common practice in Sweden. Yet, restoration activities do not always result in the return of desired biota. This study evaluated a restoration project in the Vindel River in northern Sweden in which practitioners further increased channel complexity of previously restored stream reaches by placing very large boulders (> 1 m), trees (> 8 m), and salmonid spawning gravel from adjacent upland areas into the channels. One reach restored with basic methods and another with enhanced methods were selected in each of ten different tributaries to the main channel. Geomorphic and hydraulic complexity was enhanced but the chemical composition of riparian soils and the communities of riparian plants and fish did not exhibit any clear responses to the enhanced restoration measures during the first 5 years compared to reaches restored with basic restoration methods. The variation in the collected data was among streams instead of between types of restored reaches. We conclude that restoration is a disturbance in itself, that immigration potential varies across landscapes, and that biotic recovery processes in boreal river systems are slow. We suggest that enhanced restoration has to apply a catchment-scale approach accounting for connectivity and availability of source populations, and that low-intensity monitoring has to be performed over several decades to evaluate restoration outcomes.

  • Sundberg, Sanna
    et al.
    Umeå University, Faculty of Medicine, Department of Nursing.
    Wikner, Sofia
    Umeå University, Faculty of Medicine, Department of Nursing.
    Mäns upplevelser efter genomförd prostatektomi till följd av prostatacancer: En litteraturstudie2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Men’s experiences after completed prostatectomy due to prostate cancer

    A literature study

    Abstract

    Background: Prostate cancer is the most common cancer among men in Sweden and is often treated with prostatectomy. The prevalence is expected to increase, which means that more men will be forced to seek healthcare. Studies have shown that major shortcomings exist in the care and the reason is the lack of adequate information.

    Aim: To illustrate men´s experiences after completed prostatectomy due to prostate cancer.

    Method: A literature study based on nine articles with a qualitative approach. The articles quality was reviewed, analyzed and compiled into a result.The article searches were conducted in CINAHL and PubMed.

    Results: Complications, lack of information and inadequate follow-ups caused men both physical and mental suffering, and reduced reliance on caregivers. Despite the shortcomings, men experienced gratitude for having survived and that the support they received was important. Related to the shortcomings men expressed their desire to help others.

    Conclusion: Based on the shortcomings that the men experienced, health professionals can be seen as a cause of suffering, but also as a hope in the current situation. Related to this, better understanding can lead to improved care.

  • Hirsch, Philipp Emanuel
    et al.
    Thorlacius, Magnus
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Brodin, Tomas
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Burkhardt-Holm, Patricia
    An approach to incorporate individual personality in modeling fish dispersal across in-stream barriers2017In: Ecology and Evolution, ISSN 2045-7758, E-ISSN 2045-7758, Vol. 7, no 2, 720-732 p.Article in journal (Refereed)
    Abstract [en]

    Animal personalities are an important factor that affects the dispersal of animals. In the context of aquatic species, dispersal modeling needs to consider that most freshwater ecosystems are highly fragmented by barriers reducing longitudinal connectivity. Previous research has incorporated such barriers into dispersal models under the neutral assumption that all migrating animals attempt to ascend at all times. Modeling dispersal of animals that do not perform trophic or reproductive migrations will be more realistic if it includes assumptions of which individuals attempt to overcome a barrier. We aimed to introduce personality into predictive modeling of whether a nonmigratory invasive freshwater fish (the round goby, Neogobius melanostomus) will disperse across an in-stream barrier. To that end, we experimentally assayed the personalities of 259 individuals from invasion fronts and established round goby populations. Based on the population differences in boldness, asociability, and activity, we defined a priori thresholds with bolder, more asocial, and more active individuals having a higher likelihood of ascent. We then combined the personality thresholds with swimming speed data from the literature and in situ measurements of flow velocities in the barrier. The resulting binary logistic regression model revealed probabilities of crossing a barrier which depended not only on water flow and fish swimming speed but also on animal personalities. We conclude that risk assessment through predictive dispersal modeling across fragmented landscapes can be advanced by including personality traits as parameters. The inclusion of behavior into modeling the spread of invasive species can help to improve the accuracy of risk assessments.

  • Grahn, Lisa
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Fisketurism: Inom Lilla Edet och Trollhättans kommun i Göta älv2017Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The interest in sports fishing and the number of enterprises involved is a growing phenomenon in Sweden. According to statistics from Statistics Sweden, about 1.6 million of all Swedish residents has an interest in fishing and about 10 percent of all international trips are related to fishing tourism. This indicates that there is a potential to develop fishing tourism in Swedish rivers.

    The aim of this study was to explore the fishing tourism around the salmon fishery and to identify any action that has been taken to improve conditions for the salmon in the river Göta älv, in the area of the Lilla Edet and Trollhättan municipalities. The information in this study has been collected from literature and interviews with SFK Laxen and Trollhättan Municipality.

    Göta älv is, among other rivers, regulated for hydropower production with four hydropower dams blocking the migration routes for the salmon. The main measurements that have been taken to facilitate salmon migration and improve conditions for salmon fishing are fish ladders at the power stations, and the addition of gravel to create spawning grounds. However, many projects that would improve the potential for fishing tourism are still waiting to be approved or has been denied. The result of this study has clarified the current situation for salmon and salmon fishing in Göta älv, and make some suggestions for further development of fishing tourism in the river.

  • Schlaepfer, Daniel R.
    et al.
    Bradford, John B.
    Lauenroth, William K.
    Munson, Seth M.
    Tietjen, Britta
    Hall, Sonia A.
    Wilson, Scott D.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences. Department of Biology, University of Regina, Regina, Saskatchewan, Canada.
    Duniway, Michael C.
    Jia, Gensuo
    Pyke, David A.
    Lkhagva, Ariuntsetseg
    Jamiyansharav, Khishigbayar
    Climate change reduces extent of temperate drylands and intensifies drought in deep soils2017In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, 14196Article in journal (Refereed)
    Abstract [en]

    Drylands cover 40% of the global terrestrial surface and provide important ecosystem services. While drylands as a whole are expected to increase in extent and aridity in coming decades, temperature and precipitation forecasts vary by latitude and geographic region suggesting different trajectories for tropical, subtropical, and temperate drylands. Uncertainty in the future of tropical and subtropical drylands is well constrained, whereas soil moisture and ecological droughts, which drive vegetation productivity and composition, remain poorly understood in temperate drylands. Here we show that, over the twenty first century, temperate drylands may contract by a third, primarily converting to subtropical drylands, and that deep soil layers could be increasingly dry during the growing season. These changes imply major shifts in vegetation and ecosystem service delivery. Our results illustrate the importance of appropriate drought measures and, as a global study that focuses on temperate drylands, highlight a distinct fate for these highly populated areas.

  • Makoveichuk, Elena
    et al.
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Physiological chemistry.
    Ruge, Toralph
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
    Nilsson, Solveig
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Physiological chemistry.
    Södergren, Anna
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology.
    Olivecrona, Gunilla
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Physiological chemistry.
    High concentrations of Angiopoietin-like Protein 4 detected in serum from patients with rheumatoid arthritis can be explained by non-specific antibody reactivity2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 1, e0168922Article in journal (Refereed)
    Abstract [en]

    Angiopoietin-like protein 4 (ANGPTL4) is suggested to be a master regulator of plasma triglyceride metabolism. Our aim was to study whether the previously reported high levels of ANGPTL4 detected in serum from patients with rheumatoid arthritis (RA) by ELISA was due to any specific molecular form of this protein (oligomers, monomers or fragments). ANGPTL4 levels were first determined in serum from 68 RA patients and 43 age and sex matched control subjects and the mean values differed by a factor of 5.0. Then, ANGPTL4 was analyzed after size exclusion chromatography (SEC) of serum samples. With serum from one of the RA patients with high levels of ANGPTL4, the dominant reactivity was found in fractions corresponding to high-molecular weight proteins. In addition, a minor peak of reactivity eluting late from the column was found both in the patient and in controls. By the use of Hetero-Block r, and by careful selection of antibodies, we documented non-specific reactions for ANGPTL4 in 39% of samples from the RA patients, most likely due to cross-reactivity of the antibodies with rheumatoid factor (RF). The corresponding figure for control subjects was 6.3%. After corrections for non-specific reactions, the mean level of ANGPTL4 in serum from RA patients was still significantly higher than in control individuals (mean levels were 101 +/- 62 and 67 +/- 39 ng/ml respectively, P = 0.02). We re-analyzed samples from our previously published studies on ANGPL4 levels in patients on hemodialysis and patients with diabetes type 2. These samples did not show false positive reactions. The levels of ANGPTL4 were comparable to those detected previously.

  • Qureshi, Karl
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    Att maskinöversätta sökfrågor: En studie av Google Translate och Bing Translators förmåga att översätta svenska sammansättningar i ett CLIR-perspektiv2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med denna uppsats är att undersöka hur väl Google Translate respektive Bing Translator fungerar vid översättning av sökfrågor med avseende på svenska sammansättningar, samt försöka utröna huruvida det finns något samband mellan utfallet och sammansättningarnas komplexitet.

    Testmiljön utgörs av Europaparlamentets offentliga dokumentregister. Undersökningen är emellertid begränsad till Europeiska rådets handlingar, som till antalet är 1 334 på svenska respektive 1 368 på engelska. Analysen av data har dels skett utifrån precision och återvinningsgrad, dels utifrån en kontrastiv analys för att kunna ge en mer enhetlig bild på det undersökta fenomenet.

    Resultatet visar att medelvärdet varierar mellan 0,287 och 0,506 för precision samt 0,400 och 0,614 för återvinningsgrad beroende på ordtyp och översättningstjänst. Vidare visar resultatet att det inte tycks finnas något tydligt samband mellan effektivitet och sammansättningarnas komplexitet. I stället tycks de lägre värdena bero på synonymi, och då gärna inom själva sammansättningen, samt hyponymi. I det senare fallet beror det dels på översättningstjänsternas oförmåga att återge lämpliga översättningar, dels på det engelska språkets tendens att bilda sammansättningar med lösa substantivattribut.

  • Illario, Maddalena
    et al.
    Vollenbroek-Hutten, Miriam M R
    Molloy, D William
    Menditto, Enrica
    Iaccarino, Guido
    Eklund, Patrik
    Umeå University, Faculty of Science and Technology, Department of Computing Science.
    Active and Healthy Ageing and Independent Living 20162016In: Journal of Aging Research, ISSN 2090-2204, E-ISSN 2090-2212, Vol. 2016, 8062079Article in journal (Refereed)
  • Bousquet, J
    et al.
    Hellings, P W
    Agache, I
    Bedbrook, A
    Bachert, C
    Bergmann, K C
    Bewick, M
    Bindslev-Jensen, C
    Bosnic-Anticevitch, S
    Bucca, C
    Caimmi, D P
    Camargos, P A M
    Canonica, G W
    Casale, T
    Chavannes, N H
    Cruz, A A
    De Carlo, G
    Dahl, R
    Demoly, P
    Devillier, P
    Fonseca, J
    Fokkens, W J
    Guldemond, N A
    Haahtela, T
    Illario, M
    Just, J
    Keil, T
    Klimek, L
    Kuna, P
    Larenas-Linnemann, D
    Morais-Almeida, M
    Mullol, J
    Murray, R
    Naclerio, R
    O'Hehir, R E
    Papadopoulos, N G
    Pawankar, R
    Potter, P
    Ryan, D
    Samolinski, B
    Schunemann, H J
    Sheikh, A
    Simons, F E R
    Stellato, C
    Todo-Bom, A
    Tomazic, P V
    Valiulis, A
    Valovirta, E
    Ventura, M T
    Wickman, M
    Young, I
    Yorgancioglu, A
    Zuberbier, T
    Aberer, W
    Akdis, C A
    Akdis, M
    Annesi-Maesano, I
    Ankri, J
    Ansotegui, I J
    Anto, J M
    Arnavielhe, S
    Asarnoj, A
    Arshad, H
    Avolio, F
    Baiardini, I
    Barbara, C
    Barbagallo, M
    Bateman, E D
    Beghé, B
    Bel, E H
    Bennoor, K S
    Benson, M
    Białoszewski, A Z
    Bieber, T
    Bjermer, L
    Blain, H
    Blasi, F
    Boner, A L
    Bonini, M
    Bonini, S
    Bosse, I
    Bouchard, J
    Boulet, L P
    Bourret, R
    Bousquet, P J
    Braido, F
    Briggs, A H
    Brightling, C E
    Brozek, J
    Buhl, R
    Bunu, C
    Burte, E
    Bush, A
    Caballero-Fonseca, F
    Calderon, M A
    Camuzat, T
    Cardona, V
    Carreiro-Martins, P
    Carriazo, A M
    Carlsen, K H
    Carr, W
    Cepeda Sarabia, A M
    Cesari, M
    Chatzi, L
    Chiron, R
    Chivato, T
    Chkhartishvili, E
    Chuchalin, A G
    Chung, K F
    Ciprandi, G
    de Sousa, J Correia
    Cox, L
    Crooks, G
    Custovic, A
    Dahlen, S E
    Darsow, U
    Dedeu, T
    Deleanu, D
    Denburg, J A
    De Vries, G
    Didier, A
    Dinh-Xuan, A T
    Dokic, D
    Douagui, H
    Dray, G
    Dubakiene, R
    Durham, S R
    Du Toit, G
    Dykewicz, M S
    Eklund, Patrik
    Umeå University, Faculty of Science and Technology, Department of Computing Science.
    El-Gamal, Y
    Ellers, E
    Emuzyte, R
    Farrell, J
    Fink Wagner, A
    Fiocchi, A
    Fletcher, M
    Forastiere, F
    Gaga, M
    Gamkrelidze, A
    Gemicioğlu, B
    Gereda, J E
    van Wick, R Gerth
    González Diaz, S
    Grisle, I
    Grouse, L
    Gutter, Z
    Guzmán, M A
    Hellquist-Dahl, B
    Heinrich, J
    Horak, F
    Hourihane, J O' B
    Humbert, M
    Hyland, M
    Iaccarino, G
    Jares, E J
    Jeandel, C
    Johnston, S L
    Joos, G
    Jonquet, O
    Jung, K S
    Jutel, M
    Kaidashev, I
    Khaitov, M
    Kalayci, O
    Kalyoncu, A F
    Kardas, P
    Keith, P K
    Kerkhof, M
    Kerstjens, H A M
    Khaltaev, N
    Kogevinas, M
    Kolek, V
    Koppelman, G H
    Kowalski, M L
    Kuitunen, M
    Kull, I
    Kvedariene, V
    Lambrecht, B
    Lau, S
    Laune, D
    Le, L T T
    Lieberman, P
    Lipworth, B
    Li, J
    Lodrup Carlsen, K C
    Louis, R
    Lupinek, C
    MacNee, W
    Magar, Y
    Magnan, A
    Mahboub, B
    Maier, D
    Majer, I
    Malva, J
    Manning, P
    De Manuel Keenoy, E
    Marshall, G D
    Masjedi, M R
    Mathieu-Dupas, E
    Maurer, M
    Mavale-Manuel, S
    Melén, E
    Melo-Gomes, E
    Meltzer, E O
    Mercier, J
    Merk, H
    Miculinic, N
    Mihaltan, F
    Milenkovic, B
    Millot-Keurinck, J
    Mohammad, Y
    Momas, I
    Mösges, R
    Muraro, A
    Namazova-Baranova, L
    Nadif, R
    Neffen, H
    Nekam, K
    Nieto, A
    Niggemann, B
    Nogueira-Silva, L
    Nogues, M
    Nyembue, T D
    Ohta, K
    Okamoto, Y
    Okubo, K
    Olive-Elias, M
    Ouedraogo, S
    Paggiaro, P
    Pali-Schöll, I
    Palkonen, S
    Panzner, P
    Papi, A
    Park, H S
    Passalacqua, G
    Pedersen, S
    Pereira, A M
    Pfaar, O
    Picard, R
    Pigearias, B
    Pin, I
    Plavec, D
    Pohl, W
    Popov, T A
    Portejoie, F
    Postma, D
    Poulsen, L K
    Price, D
    Rabe, K F
    Raciborski, F
    Roberts, G
    Robalo-Cordeiro, C
    Rodenas, F
    Rodriguez-Mañas, L
    Rolland, C
    Roman Rodriguez, M
    Romano, A
    Rosado-Pinto, J
    Rosario, N
    Rottem, M
    Sanchez-Borges, M
    Sastre-Dominguez, J
    Scadding, G K
    Scichilone, N
    Schmid-Grendelmeier, P
    Serrano, E
    Shields, M
    Siroux, V
    Sisul, J C
    Skrindo, I
    Smit, H A
    Solé, D
    Sooronbaev, T
    Spranger, O
    Stelmach, R
    Sterk, P J
    Strandberg, T
    Sunyer, J
    Thijs, C
    Triggiani, M
    Valenta, R
    Valero, A
    van Eerd, M
    van Ganse, E
    van Hague, M
    Vandenplas, O
    Varona, L L
    Vellas, B
    Vezzani, G
    Vazankari, T
    Viegi, G
    Vontetsianos, T
    Wagenmann, M
    Walker, S
    Wang, D Y
    Wahn, U
    Werfel, T
    Whalley, B
    Williams, D M
    Williams, S
    Wilson, N
    Wright, J
    Yawn, B P
    Yiallouros, P K
    Yusuf, O M
    Zaidi, A
    Zar, H J
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    Zhang, L
    Zhong, N
    Zidarn, M
    ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle2016In: Clinical and Translational Allergy, ISSN 2045-7022, E-ISSN 2045-7022, Vol. 6, no 47Article in journal (Refereed)
    Abstract [en]

    The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease.

  • Norman, Anita J.
    et al.
    Stronen, Astrid V.
    Fuglstad, Geir-Arne
    Ruiz-Gonzalez, Aritz
    Kindberg, Jonas
    Street, Nathaniel R.
    Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). Umeå University, Faculty of Science and Technology, Department of Plant Physiology.
    Spong, Goran
    Landscape relatedness: detecting contemporary fine-scale spatial structure in wild populations2017In: Landscape Ecology, ISSN 0921-2973, E-ISSN 1572-9761, Vol. 32, no 1, 181-194 p.Article in journal (Refereed)
    Abstract [en]

    Methods for detecting contemporary, fine-scale population genetic structure in continuous populations are scarce. Yet such methods are vital for ecological and conservation studies, particularly under a changing landscape. Here we present a novel, spatially explicit method that we call landscape relatedness (LandRel). With this method, we aim to detect contemporary, fine-scale population structure that is sensitive to spatial and temporal changes in the landscape. We interpolate spatially determined relatedness values based on SNP genotypes across the landscape. Interpolations are calculated using the Bayesian inference approach integrated nested Laplace approximation. We empirically tested this method on a continuous population of brown bears (Ursus arctos) spanning two counties in Sweden. Two areas were identified as differentiated from the remaining population. Further analysis suggests that inbreeding has occurred in at least one of these areas. LandRel enabled us to identify previously unknown fine-scale structuring in the population. These results will help direct future research efforts, conservation action and aid in the management of the Scandinavian brown bear population. LandRel thus offers an approach for detecting subtle population structure with a focus on contemporary, fine-scale analysis of continuous populations.

  • Sunduru, Naresh
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Svensson, Mona
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Cipriano, Mariateresa
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Marwaha, Sania
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Andersson, David C.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Svensson, Richard
    Fowler, Christopher J.
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
    Elofsson, Mikael
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors2017In: Journal of enzyme inhibition and medicinal chemistry (Print), ISSN 1475-6366, E-ISSN 1475-6374, Vol. 32, no 1, 513-521 p.Article in journal (Refereed)
    Abstract [en]

    Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat neurological diseases. In search of new FAAH inhibitors, we identified 2-(4-cyclohexylphenoxy)-N-(3-(oxazolo[4,5-b] pyri-din-2-yl) phenyl) acetamide, 4g, with an IC50 of 2.6 mu M as a chemical starting point for the development of potent FAAH inhibitors. Preliminary hit-to-lead optimisation resulted in 2-(4-phenylphenoxy)-N-(3-(oxazolo[4,5-b] pyridin-2-yl)phenyl) acetamide, 4i, with an IC50 of 0.35 mu M.

  • Moradabbasi Fouladi, Arman
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
    Farmaceuter i sjukvården: – En kvantitativ enkätundersökning utifrån farmaceuters och läkares perspektiv i multidisciplinära team i Sörmlands läns landsting2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • Hudson, Lawrence N.
    et al.
    Newbold, Tim
    Contu, Sara
    Hill, Samantha L. L.
    Lysenko, Igor
    De Palma, Adriana
    Phillips, Helen R. P.
    Alhusseini, Tamera I.
    Bedford, Felicity E.
    Bennett, Dominic J.
    Booth, Hollie
    Burton, Victoria J.
    Chng, Charlotte W. T.
    Choimes, Argyrios
    Correia, David L. P.
    Day, Julie
    Echeverria-Londono, Susy
    Emerson, Susan R.
    Gao, Di
    Garon, Morgan
    Harrison, Michelle L. K.
    Ingram, Daniel J.
    Jung, Martin
    Kemp, Victoria
    Kirkpatrick, Lucinda
    Martin, Callum D.
    Pan, Yuan
    Pask-Hale, Gwilym D.
    Pynegar, Edwin L.
    Robinson, Alexandra N.
    Sanchez-Ortiz, Katia
    Senior, Rebecca A.
    Simmons, Benno I.
    White, Hannah J.
    Zhang, Hanbin
    Aben, Job
    Abrahamczyk, Stefan
    Adum, Gilbert B.
    Aguilar-Barquero, Virginia
    Aizen, Marcelo A.
    Albertos, Belen
    Alcala, E. L.
    del Mar Alguacil, Maria
    Alignier, Audrey
    Ancrenaz, Marc
    Andersen, Alan N.
    Arbelaez-Cortes, Enrique
    Armbrecht, Inge
    Arroyo-Rodriguez, Victor
    Aumann, Tom
    Axmacher, Jan C.
    Azhar, Badrul
    Azpiroz, Adrian B.
    Baeten, Lander
    Bakayoko, Adama
    Baldi, Andras
    Banks, John E.
    Baral, Sharad K.
    Barlow, Jos
    Barratt, Barbara I. P.
    Barrico, Lurdes
    Bartolommei, Paola
    Barton, Diane M.
    Basset, Yves
    Batary, Peter
    Bates, Adam J.
    Baur, Bruno
    Bayne, Erin M.
    Beja, Pedro
    Benedick, Suzan
    Berg, Ake
    Bernard, Henry
    Berry, Nicholas J.
    Bhatt, Dinesh
    Bicknell, Jake E.
    Bihn, Jochen H.
    Blake, Robin J.
    Bobo, Kadiri S.
    Bocon, Roberto
    Boekhout, Teun
    Bohning-Gaese, Katrin
    Bonham, Kevin J.
    Borges, Paulo A. V.
    Borges, Sergio H.
    Boutin, Celine
    Bouyer, Jeremy
    Bragagnolo, Cibele
    Brandt, Jodi S.
    Brearley, Francis Q.
    Brito, Isabel
    Bros, Vicenc
    Brunet, Jorg
    Buczkowski, Grzegorz
    Buddle, Christopher M.
    Bugter, Rob
    Buscardo, Erika
    Buse, Joern
    Cabra-Garcia, Jimmy
    Caceres, Nilton C.
    Cagle, Nicolette L.
    Calvino-Cancela, Maria
    Cameron, Sydney A.
    Cancello, Eliana M.
    Caparros, Rut
    Cardoso, Pedro
    Carpenter, Dan
    Carrijo, Tiago F.
    Carvalho, Anelena L.
    Cassano, Camila R.
    Castro, Helena
    Castro-Luna, Alejandro A.
    Cerda, Rolando B.
    Cerezo, Alexis
    Chapman, Kim Alan
    Chauvat, Matthieu
    Christensen, Morten
    Clarke, Francis M.
    Cleary, Daniel F. R.
    Colombo, Giorgio
    Connop, Stuart P.
    Craig, Michael D.
    Cruz-Lopez, Leopoldo
    Cunningham, Saul A.
    D'Aniello, Biagio
    D'Cruze, Neil
    da Silva, Pedro Giovani
    Dallimer, Martin
    Danquah, Emmanuel
    Darvill, Ben
    Dauber, Jens
    Davis, Adrian L. V.
    Dawson, Jeff
    de Sassi, Claudio
    de Thoisy, Benoit
    Deheuvels, Olivier
    Dejean, Alain
    Devineau, Jean-Louis
    Diekoetter, Tim
    Dolia, Jignasu V.
    Dominguez, Erwin
    Dominguez-Haydar, Yamileth
    Dorn, Silvia
    Draper, Isabel
    Dreber, Niels
    Dumont, Bertrand
    Dures, Simon G.
    Dynesius, Mats
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Edenius, Lars
    Eggleton, Paul
    Eigenbrod, Felix
    Elek, Zoltan
    Entling, Martin H.
    Esler, Karen J.
    De Lima, Ricardo F.
    Faruk, Aisyah
    Farwig, Nina
    Fayle, Tom M.
    Felicioli, Antonio
    Felton, Annika M.
    Fensham, Roderick J.
    Fernandez, Ignacio C.
    Ferreira, Catarina C.
    Ficetola, Gentile F.
    Fiera, Cristina
    Filgueiras, Bruno K. C.
    Firincioglu, Huseyin K.
    Flaspohler, David
    Floren, Andreas
    Fonte, Steven J.
    Fournier, Anne
    Fowler, Robert E.
    Franzen, Markus
    Fraser, Lauchlan H.
    Fredriksson, Gabriella M.
    Freire-, Geraldo B., Jr.
    Frizzo, Tiago L. M.
    Fukuda, Daisuke
    Furlani, Dario
    Gaigher, Rene
    Ganzhorn, Joerg U.
    Garcia, Karla P.
    Garcia-R, Juan C.
    Garden, Jenni G.
    Garilleti, Ricardo
    Ge, Bao-Ming
    Gendreau-Berthiaume, Benoit
    Gerard, Philippa J.
    Gheler-Costa, Carla
    Gilbert, Benjamin
    Giordani, Paolo
    Giordano, Simonetta
    Golodets, Carly
    Gomes, Laurens G. L.
    Gould, Rachelle K.
    Goulson, Dave
    Gove, Aaron D.
    Granjon, Laurent
    Grass, Ingo
    Gray, Claudia L.
    Grogan, James
    Gu, Weibin
    Guardiola, Moises
    Gunawardene, Nihara R.
    Gutierrez, Alvaro G.
    Gutierrez-Lamus, Doris L.
    Haarmeyer, Daniela H.
    Hanley, Mick E.
    Hanson, Thor
    Hashim, Nor R.
    Hassan, Shombe N.
    Hatfield, Richard G.
    Hawes, Joseph E.
    Hayward, Matt W.
    Hebert, Christian
    Helden, Alvin J.
    Henden, John-Andre
    Henschel, Philipp
    Hernandez, Lionel
    Herrera, James P.
    Herrmann, Farina
    Herzog, Felix
    Higuera-Diaz, Diego
    Hilje, Branko
    Hofer, Hubert
    Hoffmann, Anke
    Horgan, Finbarr G.
    Hornung, Elisabeth
    Horvath, Roland
    Hylander, Kristoffer
    Isaacs-Cubides, Paola
    Ishida, Hiroaki
    Ishitani, Masahiro
    Jacobs, Carmen T.
    Jaramillo, Victor J.
    Jauker, Birgit
    Jimenez Hernandez, F.
    Johnson, McKenzie F.
    Jolli, Virat
    Jonsell, Mats
    Juliani, S. Nur
    Jung, Thomas S.
    Kapoor, Vena
    Kappes, Heike
    Kati, Vassiliki
    Katovai, Eric
    Kellner, Klaus
    Kessler, Michael
    Kirby, Kathryn R.
    Kittle, Andrew M.
    Knight, Mairi E.
    Knop, Eva
    Kohler, Florian
    Koivula, Matti
    Kolb, Annette
    Kone, Mouhamadou
    Koroesi, Adam
    Krauss, Jochen
    Kumar, Ajith
    Kumar, Raman
    Kurz, David J.
    Kutt, Alex S.
    Lachat, Thibault
    Lantschner, Victoria
    Lara, Francisco
    Lasky, Jesse R.
    Latta, Steven C.
    Laurance, William F.
    Lavelle, Patrick
    Le Feon, Violette
    LeBuhn, Gretchen
    Legare, Jean-Philippe
    Lehouck, Valerie
    Lencinas, Maria V.
    Lentini, Pia E.
    Letcher, Susan G.
    Li, Qi
    Litchwark, Simon A.
    Littlewood, Nick A.
    Liu, Yunhui
    Lo-Man-Hung, Nancy
    Lopez-Quintero, Carlos A.
    Louhaichi, Mounir
    Lovei, Gabor L.
    Lucas-Borja, Manuel Esteban
    Luja, Victor H.
    Luskin, Matthew S.
    MacSwiney G, M. Cristina
    Maeto, Kaoru
    Magura, Tibor
    Mallari, Neil Aldrin
    Malone, Louise A.
    Malonza, Patrick K.
    Malumbres-Olarte, Jagoba
    Mandujano, Salvador
    Maren, Inger E.
    Marin-Spiotta, Erika
    Marsh, Charles J.
    Marshall, E. J. P.
    Martinez, Eliana
    Pastur, Guillermo Martinez
    Mateos, David Moreno
    Mayfield, Margaret M.
    Mazimpaka, Vicente
    McCarthy, Jennifer L.
    McCarthy, Kyle P.
    McFrederick, Quinn S.
    McNamara, Sean
    Medina, Nagore G.
    Medina, Rafael
    Mena, Jose L.
    Mico, Estefania
    Mikusinski, Grzegorz
    Milder, Jeffrey C.
    Miller, James R.
    Miranda-Esquivel, Daniel R.
    Moir, Melinda L.
    Morales, Carolina L.
    Muchane, Mary N.
    Muchane, Muchai
    Mudri-Stojnic, Sonja
    Munira, A. Nur
    Muonz-Alonso, Antonio
    Munyekenye, B. F.
    Naidoo, Robin
    Naithani, A.
    Nakagawa, Michiko
    Nakamura, Akihiro
    Nakashima, Yoshihiro
    Naoe, Shoji
    Nates-Parra, Guiomar
    Gutierrez, Dario A. Navarrete
    Navarro-Iriarte, Luis
    Ndang'ang'a, Paul K.
    Neuschulz, Eike L.
    Ngai, Jacqueline T.
    Nicolas, Violaine
    Nilsson, Sven G.
    Noreika, Norbertas
    Norfolk, Olivia
    Noriega, Jorge Ari
    Norton, David A.
    Noeske, Nicole M.
    Nowakowski, A. Justin
    Numa, Catherine
    O'Dea, Niall
    O'Farrell, Patrick J.
    Oduro, William
    Oertli, Sabine
    Ofori-Boateng, Caleb
    Oke, Christopher Omamoke
    Oostra, Vicencio
    Osgathorpe, Lynne M.
    Eduardo Otavo, Samuel
    Page, Navendu V.
    Paritsis, Juan
    Parra-H, Alejandro
    Parry, Luke
    Pe'er, Guy
    Pearman, Peter B.
    Pelegrin, Nicolas
    Pelissier, Raphael
    Peres, Carlos A.
    Peri, Pablo L.
    Persson, Anna S.
    Petanidou, Theodora
    Peters, Marcell K.
    Pethiyagoda, Rohan S.
    Phalan, Ben
    Philips, T. Keith
    Pillsbury, Finn C.
    Pincheira-Ulbrich, Jimmy
    Pineda, Eduardo
    Pino, Joan
    Pizarro-Araya, Jaime
    Plumptre, A. J.
    Poggio, Santiago L.
    Politi, Natalia
    Pons, Pere
    Poveda, Katja
    Power, Eileen F.
    Presley, Steven J.
    Proenca, Vania
    Quaranta, Marino
    Quintero, Carolina
    Rader, Romina
    Ramesh, B. R.
    Ramirez-Pinilla, Martha P.
    Ranganathan, Jai
    Rasmussen, Claus
    Redpath-Downing, Nicola A.
    Reid, J. Leighton
    Reis, Yana T.
    Rey Benayas, Jose M.
    Carlos Rey-Velasco, Juan
    Reynolds, Chevonne
    Ribeiro, Danilo Bandini
    Richards, Miriam H.
    Richardson, Barbara A.
    Richardson, Michael J.
    Macip Rios, Rodrigo
    Robinson, Richard
    Robles, Carolina A.
    Roembke, Joerg
    Romero-Duque, Luz Piedad
    Ros, Matthias
    Rosselli, Loreta
    Rossiter, Stephen J.
    Roth, Dana S.
    Roulston, T'ai H.
    Rousseau, Laurent
    Rubio, Andre V.
    Ruel, Jean-Claude
    Sadler, Jonathan P.
    Safian, Szabolcs
    Saldana-Vazquez, Romeo A.
    Sam, Katerina
    Samnegard, Ulrika
    Santana, Joana
    Santos, Xavier
    Savage, Jade
    Schellhorn, Nancy A.
    Schilthuizen, Menno
    Schmiedel, Ute
    Schmitt, Christine B.
    Schon, Nicole L.
    Schuepp, Christof
    Schumann, Katharina
    Schweiger, Oliver
    Scott, Dawn M.
    Scott, Kenneth A.
    Sedlock, Jodi L.
    Seefeldt, Steven S.
    Shahabuddin, Ghazala
    Shannon, Graeme
    Sheil, Douglas
    Sheldon, Frederick H.
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    Siebert, Stefan J.
    Silva, Fernando A. B.
    Simonetti, Javier A.
    Slade, Eleanor M.
    Smith, Jo
    Smith-Pardo, Allan H.
    Sodhi, Navjot S.
    Somarriba, Eduardo J.
    Sosa, Ramon A.
    Soto Quiroga, Grimaldo
    St-Laurent, Martin-Hugues
    Starzomski, Brian M.
    Stefanescu, Constanti
    Steffan-Dewenter, Ingolf
    Stouffer, Philip C.
    Stout, Jane C.
    Strauch, Ayron M.
    Struebig, Matthew J.
    Su, Zhimin
    Suarez-Rubio, Marcela
    Sugiura, Shinji
    Summerville, Keith S.
    Sung, Yik-Hei
    Sutrisno, Hari
    Svenning, Jens-Christian
    Teder, Tiit
    Threlfall, Caragh G.
    Tiitsaar, Anu
    Todd, Jacqui H.
    Tonietto, Rebecca K.
    Torre, Ignasi
    Tothmeresz, Bela
    Tscharntke, Teja
    Turner, Edgar C.
    Tylianakis, Jason M.
    Uehara-Prado, Marcio
    Urbina-Cardona, Nicolas
    Vallan, Denis
    Vanbergen, Adam J.
    Vasconcelos, Heraldo L.
    Vassilev, Kiril
    Verboven, Hans A. F.
    Verdasca, Maria Joao
    Verdu, Jose R.
    Vergara, Carlos H.
    Vergara, Pablo M.
    Verhulst, Jort
    Virgilio, Massimiliano
    Van Vu, Lien
    Waite, Edward M.
    Walker, Tony R.
    Wang, Hua-Feng
    Wang, Yanping
    Watling, James I.
    Weller, Britta
    Wells, Konstans
    Westphal, Catrin
    Wiafe, Edward D.
    Williams, Christopher D.
    Willig, Michael R.
    Woinarski, John C. Z.
    Wolf, Jan H. D.
    Wolters, Volkmar
    Woodcock, Ben A.
    Wu, Jihua
    Wunderle, Joseph M., Jr.
    Yamaura, Yuichi
    Yoshikura, Satoko
    Yu, Douglas W.
    Zaitsev, Andrey S.
    Zeidler, Juliane
    Zou, Fasheng
    Collen, Ben
    Ewers, Rob M.
    Mace, Georgina M.
    Purves, Drew W.
    Scharlemann, Joern P. W.
    Purvis, Andy
    The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project2017In: Ecology and Evolution, ISSN 2045-7758, E-ISSN 2045-7758, Vol. 7, no 1, 145-188 p.Article in journal (Refereed)
    Abstract [en]

    The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.

  • Hasselquist, Eliza Maher
    et al.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences. Department of Forest Ecology and Management, Swedish University of Agricultural Sciences, Umeå, Sweden.
    Hasselquist, Niles J.
    Sparks, Jed P.
    Nilsson, Christer
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Recovery of nitrogen cycling in riparian zones after stream restoration using delta N-15 along a 25-year chronosequence in northern Sweden2017In: Plant and Soil, ISSN 0032-079X, E-ISSN 1573-5036, Vol. 410, no 1-2, 423-436 p.Article in journal (Refereed)
    Abstract [en]

    Swedish boreal streams were modified to transport timber by pushing boulders to stream sides, creating levees that disconnected streams from riparian areas. Many streams have since been restored and our goal was to understand how this affects riparian nitrogen (N) cycling. We compared the natural abundance of delta N-15 isotopes in foliage and roots of Filipendula ulmaria plus soils and litter along streams restored 2-25 years ago. We measured sources of N, potential immobilization of N, namely plant diversity and biomass, and the amount and sources of carbon (C) to determine if these were important for describing riparian N cycling. The delta N-15 of F. ulmaria foliage changed dramatically just after restoration compared to the channelized, disconnected state and then converged over the next 25 years with the steady-state reference. The disturbance and reconnection of the stream with the riparian zone during restoration created a short-term pulse of N availability and gaseous losses of N as a result of enhanced microbial processing of N. With increasing time since restoration, N availability appears to have decreased, and N sources changed to those derived from mycorrhizae, amino acids, or the humus layer, or there was enhanced N-use efficiency by older, more diverse plant communities.

  • Bandau, Franziska
    et al.
    Umeå University, Faculty of Science and Technology, Department of Plant Physiology.
    Albrectsen, Benedicte Riber
    Umeå University, Faculty of Science and Technology, Department of Plant Physiology.
    Julkunen-Tiitto, Riitta
    Gundale, Michael J.
    Genotypic variability in Populus tremula L. affects how anthropogenic nitrogen enrichment influences litter decomposition2017In: Plant and Soil, ISSN 0032-079X, E-ISSN 1573-5036, Vol. 410, no 1-2, 467-481 p.Article in journal (Refereed)
    Abstract [en]

    Boreal forests can receive substantial nitrogen (N) enrichment via atmospheric N deposition and industrial forest fertilization. While it is known that N enrichment can impact ecosystem properties, such as litter decomposition, it remains poorly understood how genetic variability within plant species modifies these impacts. We grew replicates of ten Populus tremula L. genotypes (GTs) under 3 N conditions; ambient, and levels representing atmospheric N deposition and industrial forest fertilization. We measured leaf and litter physical and chemical traits, and conducted a litter decomposition assay. Leaf traits varied due to N treatment, GT, and constitutive tannin levels. Leaf traits were in some cases correlated with litter traits, and decomposition was influenced by single and interactive effects of N and GT. Nitrogen addition unexpectedly decelerated decomposition, potentially due to changes in specific leaf area (SLA). Variation in decomposition rates among the GTs was best explained by their differences in SLA, and lignin:N ratio. Nitrogen addition also caused a shift in which traits most strongly influenced decomposition. Our findings highlight that the considerable diversity present in tree species can have a strong influence on ecosystem processes, such as decomposition, and how these processes respond to environmental change.

  • Bengtsson, Karin
    et al.
    Jacobsson, Lennart T H
    Rydberg, Barbro
    Kvist, Göran
    Torstenson, Tomas
    Dehlin, Mats
    Hilme, Elisabet
    Lindhé, Anna
    Wallerstedt, Susanna Maria
    Forsblad-d'Elia, Helena
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology. Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Box 480, S-405 30, Gothenburg, Sweden..
    Comparisons between comorbid conditions and health care consumption in rheumatoid arthritis patients with or without biological disease-modifying antirheumatic drugs: a register-based study2016In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 17, no 1, 499Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Symptoms and prognosis of patients with rheumatoid arthritis (RA) have improved with more intensive therapy, including the biological disease-modifying anti-rheumatic drugs (bDMARDs). Real life data concerning how comorbidities are distributed among patients treated or not treated with bDMARDs are scarce. Our objective was to investigate differences in comorbidity and health care consumption in RA patients, with and without bDMARDs.

    METHODS: This cross-sectional study was performed in the Southwestern part of Sweden. Patients, aged ≥ 18 years and diagnosed with RA in secondary health care during 2009-2010, were identified in the regional health care database. Aggregated data of comorbidity and health care consumption were retrieved between 2006 and 2010. RA patients treated with bDMARDs on 31st December 2010 were identified in the Swedish Rheumatology Quality Register (SRQ), which includes the biologics register Anti-Rheumatic Therapy in Sweden (ARTIS). Descriptive, comparative, univariate and multiple logistic regression analyses were used to identify factors associated with bDMARDs.

    RESULTS: Seven thousand seven hundred and twelve (7712) RA patients were identified (age 64.8 ± 14.9 years, women 74.3%), of whom 1137 (14.7%) were treated with bDMARDs. Overall, the most common comorbidities were infections (69.2%), hypertension (41.1%), chronic respiratory disease (15.3%), ischemic heart disease (14.0%) and malignancy (13.7%). Patients without bDMARDs were older and had more comorbidity. In the multiple logistic regression analysis, older age, cerebrovascular and chronic respiratory disease, heart failure, depression and malignancy were all associated with no present bDMARDs. Infections were associated with bDMARDs. Patients treated with bDMARDs consumed more secondary outpatient care but less visits in primary health care compared to patients without bDMARDs.

    CONCLUSIONS: Patients treated with bDMARDs versus no bDMARDs were younger and had significantly lower period prevalence for most common comorbidities, with the exception of infections. Differences in comorbidities between RA patients with or without bDMARDs should be taken into consideration when evaluating effectiveness and safety of bDMARDs in ordinary care.

  • Klingberg, Eva
    et al.
    Strid, Hans
    Ståhl, Arne
    Deminger, Anna
    Carlsten, Hans
    Öhman, Lena
    Forsblad-d'Elia, Helena
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Rheumatology. Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at the University of Gothenburg, Guldhedsgatan 10A, S-413 46, Gothenburg, Sweden..
    A longitudinal study of fecal calprotectin and the development of inflammatory bowel disease in ankylosing spondylitis.2017In: Arthritis Research & Therapy, ISSN 1478-6354, E-ISSN 1478-6362, Vol. 19, no 21Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Patients with ankylosing spondylitis (AS) are at increased risk of developing inflammatory bowel disease (IBD). We aimed to determine the variation in fecal calprotectin in AS over 5 years in relation to disease activity and medication and also to study the incidence of and predictors for development of IBD.

    METHODS: Fecal calprotectin was assessed at baseline (n = 204) and at 5-year follow-up (n = 164). The patients answered questionnaires and underwent clinical evaluations. At baseline and at 5-year follow-up, ileocolonoscopy was performed in patients with fecal calprotectin ≥500 mg/kg and ≥200 mg/kg, respectively. The medical records were checked for diagnoses of IBD during the follow-up period.

    RESULTS: Fecal calprotectin >50 mg/kg was found in two-thirds of the patients at both study visits. In 80% of the patients, fecal calprotectin changed by <200 mg/kg between the two measuring points. Baseline fecal calprotectin was positively correlated with Ankylosing Spondylitis Disease Activity Score based on C-reactive protein, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, C-reactive protein, erythrocyte sedimentation rate, and fecal calprotectin at 5-year follow-up. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) was associated with higher fecal calprotectin, and 3-week cessation of NSAIDs resulted in a drop of a median 116 mg/kg in fecal calprotectin. The use of tumor necrosis factor (TNF) blockers was associated with lower fecal calprotectin at both visits, but the users of TNF receptor fusion proteins had significantly higher fecal calprotectin than users of anti-TNF antibodies at 5-year follow-up. The 5-year incidence of Crohn's disease (CD) was 1.5% and was predicted by high fecal calprotectin.

    CONCLUSIONS: Fecal calprotectin was elevated in a majority of the patients and was associated with disease activity and medication at both visits. CD developed in 1.5% of the patients with AS, and a high fecal calprotectin was the main predictor thereof. The results support a link between inflammation in the gut and the musculoskeletal system in AS. We propose that fecal calprotectin may be a potential biomarker to identify patients with AS at risk of developing IBD.

    TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00858819 . Registered 9 March 2009. Last updated 28 May 2015.