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  • Norante, Rosa Pia
    et al.
    Massimino, Maria Lina
    Lorenzon, Paolo
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Univ Padua, Dept Biomed Sci, Padua, Italy.
    De Mario, Agnese
    Peggion, Caterina
    Vicario, Mattia
    Albiero, Mattia
    Sorgato, Maria Catia
    Lopreiato, Raffaele
    Bertoli, Alessandro
    Generation and validation of novel adeno-associated viral vectors for the analysis of Ca2+ homeostasis in motor neurons2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, 6521Article in journal (Refereed)
    Abstract [en]

    A finely tuned Ca2+ homeostasis in restricted cell domains is of fundamental importance for neurons, where transient Ca2+ oscillations direct the proper coordination of electro-chemical signals and overall neuronal metabolism. Once such a precise regulation is unbalanced, however, neuronal functions and viability are severely compromised. Accordingly, disturbed Ca2+ metabolism has often been claimed as a major contributor to different neurodegenerative disorders, such as amyotrophic lateral sclerosis that is characterised by selective motor neuron (MN) damage. This notion highlights the need for probes for the specific and precise analysis of local Ca2+ dynamics in MNs. Here, we generated and functionally validated adeno-associated viral vectors for the expression of gene-encoded fluorescent Ca2+ indicators targeted to different cell domains, under the transcriptional control of a MN-specific promoter. We demonstrated that the probes are specifically expressed, and allow reliable local Ca2+ measurements, in MNs from murine primary spinal cord cultures, and can also be expressed in spinal cord MNs in vivo, upon systemic administration to newborn mice. Preliminary analyses using these novel vectors have shown larger cytosolic Ca2+ responses following stimulation of AMPA receptors in the cytosol of primary cultured MNs from a murine genetic model of ALS compared to the healthy counterpart.

  • Wallert, John
    et al.
    Department of Women's and Children's Health, Uppsala University, Sweden.
    Held, Claes
    Department of Medical Sciences: Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Centre, Uppsala University, Sweden4Department of Medical Sciences, Cardiology, Uppsala University, Sweden.
    Madison, Guy
    Umeå University, Faculty of Social Sciences, Department of Psychology.
    Olsson, Erik
    Department of Women's and Children's Health, Uppsala University, Sweden.
    Temporal changes in myocardial infarction incidence rates are associated with periods of perceived psychosocial stress: A SWEDEHEART national registry study2017In: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 191, 12-20 p.Article in journal (Refereed)
    Abstract [en]


    Psychosocial stress might trigger myocardial infarction (MI). Increased MI incidence coincides with recurrent time periods during the year perceived as particularly stressful in the population.


    A stress-triggering hypothesis on the risk of MI onset was investigated with Swedish population data on MI hospital admission date and symptom onset date (N = 156,690; 148,176) as registered from 2006 through 2013 in the national quality registry database Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies (SWEDEHEART). Poisson regression was applied to analyze daily MI rates during days belonging to the Christmas and New Year holidays, turns of the month, Mondays, weekends, and summer vacation in July compared with remaining control days.


    Adjusted incidence rate ratios (IRRs) for MI rates were higher during Christmas and New Year holidays (IRR = 1.07 [1.04-1.09], P < .001) and on Mondays (IRR = 1.11 [1.09-1.13], P < .001) and lower in July (IRR = 0.92 [0.90-0.94], P < .001) and over weekends (IRR = 0.88 [0.87-0.89], P < .001), yet not during the turns of the month (IRR = 1.01 [1.00–1.02], P = .891). These findings were also predominantly robust with symptom onset as alternative outcome, when adjusting for both established and some suggested-but-untested confounders, and in 8 subgroups.


    Fluctuations in daily MI incidence rates are systematically related to time periods of presumed psychosocial stress. Further research might clarify mechanisms that are amenable to clinical alteration.

  • Sandlund, Marlene
    et al.
    Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Physiotherapy.
    Skelton, Dawn A.
    Pohl, Petra
    Ahlgren, Christina
    Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Physiotherapy.
    Melander-Wikman, Anita
    Lundin-Olsson, Lillemor
    Gender perspectives on views and preferences of older people on exercise to prevent falls: a systematic mixed studies review2017In: BMC Geriatrics, ISSN 1471-2318, E-ISSN 1471-2318, Vol. 17, 58Article in journal (Refereed)
    Abstract [en]

    Background: To offer fall prevention exercise programs that attract older people of both sexes there is a need to understand both women's and men's views and preferences regarding these programs. This paper aims to systematically review the literature to explore any underlying gender perspectives or gender interpretations on older people's views or preferences regarding uptake and adherence to exercise to prevent falls. Methods: A review of the literature was carried out using a convergent qualitative design based on systematic searches of seven electronic databases (PubMed, CINAHL, Amed, PsycINFO, Scopus, PEDro, and OTseeker). Two investigators identified eligible studies. Each included article was read by at least two authors independently to extract data into tables. Views and preferences reported were coded and summarized in themes of facilitators and barriers using a thematic analysis approach. Results: Nine hundred and nine unique studies were identified. Twenty five studies met the criteria for inclusion. Only five of these contained a gender analysis of men's and women's views on fall prevention exercises. The results suggests that both women and men see women as more receptive to and in more need of fall prevention messages. The synthesis from all 25 studies identified six themes illustrating facilitators and six themes describing barriers for older people either starting or adhering to fall prevention exercise. The facilitators were: support from professionals or family; social interaction; perceived benefits; a supportive exercise context; feelings of commitment; and having fun. Barriers were: practical issues; concerns about exercise; unawareness; reduced health status; lack of support; and lack of interest. Considerably more women than men were included in the studies. Conclusion: Although there is plenty of information on the facilitators and barriers to falls prevention exercise in older people, there is a distinct lack of studies investigating differences or similarities in older women's and men's views regarding fall prevention exercise. In order to ensure that fall prevention exercise is appealing to both sexes and that the inclusion of both men and women are encouraged, more research is needed to find out whether gender differences exists and whether practitioners need to offer a range of opportunities and support strategies to attract both women and men to falls prevention exercise.

  • Karhina, Kateryna
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Ghazinour, Mehdi
    Umeå University, Faculty of Social Sciences, Police Education Unit at Umeå University.
    Ng, Nawi
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR).
    Eriksson, Malin
    Umeå University, Faculty of Social Sciences, Department of Social Work.
    Voluntary work during times of military crisis: What motivates people to be involved and what are the effects on well-being?2017In: Psychology, ISSN 2152-7180, E-ISSN 2152-7199, Vol. 8, 1601-1619 p.Article in journal (Refereed)
    Abstract [en]

    The positive health effects of volunteering are quite well described in the lite- rature; however, potential negative effects of volunteering are less explored. Volunteering got attention in Ukraine because of the recent political crisis that brought military conflict to the Eastern part of the country in 2014. In- formal volunteering has transformed into a formal one. In order to be able to organize volunteering that promotes well-being, it is important to have more in-depth knowledge about motives behind volunteering as well as the positive and potential negative effects of it. We explore the case voluntary work in of one of the cities in Ukraine. Military conflict context has its own specifics and different motives make people act voluntarily. There are goal-oriented, val- ue-oriented, affectual and traditional motives present in our data. The data shows that involvement in volunteering brings positive returns on well-being of the providers such as enlarging the circles of friendship and expanding the networks volunteers involved in; brings positive emotions into life; compen- sates the efforts and gives meaning to life. However, the negative effects of volunteering are also present. They are physical tiredness and a lot of time spent on volunteering activities; becoming disconnected from the ordinary (non-volunteering) world; unsafety; neglect of own needs and experiences of negative emotions out of the involvement in volunteering activities. 

  • Kindstedt, Elin
    et al.
    Umeå University, Faculty of Medicine, Department of Odontology.
    Koskinen Holm, Cecilia
    Umeå University, Faculty of Medicine, Department of Odontology.
    Sulniute, Rima
    Umeå University, Faculty of Medicine, Department of Odontology.
    Martinez-Carrasco, Irene
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Lundmark, Richard
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Lundberg, Pernilla
    Umeå University, Faculty of Medicine, Department of Odontology.
    CCL11, a novel mediator of inflammatory bone resorption2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, no 1, 5334Article in journal (Refereed)
    Abstract [en]

    Normal bone homeostasis, which is regulated by bone-resorbing osteoclasts and bone-forming osteoblasts is perturbed by inflammation. Inchronic inflammatory disease with disturbed bone remodelling, e.g. rheumatoid arthritis, patients show increased serum levels of the chemokine eotaxin-1 (CCL11). Herein, we demonstrate an inflammatory driven expression of CCL11 in bone tissue and a novel role of CCL11 in osteoclast migration and resorption. Using an inflammatory bone lesion model and primary cell cultures, we discovered that osteoblasts express CCL11 in vivo and in vitro and that expression increased during inflammatory conditions. Osteoclasts did not express CCL11, but the high affinity receptor CCR3 was significantly upregulated during osteoclast differentiation and found to colocalise with CCL11. Exogenous CCL11 was internalised in osteoclast and stimulated the migration of pre-osteoclast and concomitant increase in bone resorption. Our data pinpoints that the CCL11/CCR3 pathway could be a new target for treatment of inflammatory bone resorption.

  • Calla, Johanna
    et al.
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Business Administration.
    Hedenström, Lisa
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Business Administration.
    Konflikten mellan svinn och slut-i-hyllan: En kvalitativ studie om hanteringen av färskvaror i dagligvaruhandelns försörjningskedja2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    I följande studie behandlas dagligvaruhandelns försörjningskedja och dess färskvarusortiment. Det har teoretiskt visats att dagligvaruhandeln är en bransch som präglas av osäker efterfrågan som medfört höga lagernivåer och svinn i kedjan. Utifrån en identifierad problematik kring hantering av färskvaror i en bransch kantad av osäker efterfrågan, riktar sig studien till att besvara problemformuleringarna; “Hur hanteras osäker efterfrågan inom färskvarusortimentet i dagligvaruhandelns försörjningskedja?” samt “Hur kan höga lagernivåer och svinn minskas inom dagligvaruhandelns försörjningskedja utan att det resulterar i slut-i-hyllan-problematik i färskvarusortimentet?”. Utifrån dessa problematiseringar beskrivs studiens syfte som; att undersöka hur konsekvenserna av osäker efterfrågan såsom höga lagernivåer och svinn kan reduceras. Detta trots färskvarors karaktär och aktörers önskan att tillgodose efterföljande leds efterfrågan och undvika slut-i-hyllan. För att undersöka denna konflikt är ett delsyfte i studien att skapa förståelse för hur osäker efterfrågan hanteras av olika aktörer i dagligvaruhandelns försörjningskedja.

    För att besvara dessa problemformuleringaroch uppfylla det angivna syftet, har en abduktiv ansats använts samt en kvalitativ metodik. Detta har resulterat i semistrukturerade intervjuer med aktörer i olika delar av dagligvaruhandelns försörjningskedja. Såväl producenter, grossister och butiker har medverkat i studien. Detta för att studiens skall kunna bidra med en helhetsbild över försörjningskedjan och hur den osäkra efterfrågan hanteras i denna.

    Utifrån studiens resultat visas det att den osäkra efterfrågan som påvisats teoretiskt, inte återfinns i samma omfattning i praktiken gällande aktörernas ordinarie sortiment av färskvaror. Vad som däremot framkom var att kampanjprodukter, innehar desto mer osäkerhet och efterfrågan för dessa är svårare att uppskatta. Resultatet visade att aktörerna hanterar dessa osäkerheter genom att prognostisera efterfrågan samt genom viss informationsdelning mellan parterna. Resultatet visade även att samtliga aktörer i regel föredrar att lagerhålla färskvaror som kan riskera att resultera i svinn snarare än att riskera slut-i-hyllan och brist till kund. Detta visade sig vara en uppfattning som sträckte sig över samtliga led av försörjningskedjan, med undantaget för dyrare produkter som aktörerna menar blir för dyra att lagerhålla och riskera att slänga. Den hållbara vinkel som studien även antagit, visar att det krävs ekonomiska incitament för att aktörerna ska genomföra hållbara aktiviteter.