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Mobarrez, F., Antoniewicz, L., Hedman, L., Bosson, J. A. & Lundbäck, M. (2020). Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers. Atherosclerosis
Open this publication in new window or tab >>Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers
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2020 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND AND AIMS: E-cigarette use is increasingly common. Whether e-cigarettes are harmful to human health is an intensely debated subject. In order to investigate whether e-cigarettes with and without nicotine cause different vascular responses, we obtained blood samples from healthy young volunteers who performed brief active e-cigarette inhalations. Extracellular vesicles (EVs) of endothelial and platelet origin were measured to determine vascular changes.

METHODS: Using a randomized, double-blind, crossover design, 17 healthy occasional smokers inhaled 30 puffs of e-cigarette vapor during 30 min. Blood samples were collected at baseline, as well as at 0, 2, 4 and 6 h post-exposure. EVs from platelets and endothelial cells were measured by flow cytometry.

RESULTS: Platelet and endothelial derived EVs were significantly increased with peak levels seen at 4 h following exposure to active inhalation of e-cigarette vapor with nicotine. Moreover, platelet derived EVs, expressing platelet activation marker P-selectin and the inflammation marker, CD40 ligand, were also significantly increased following inhalation of e-cigarette vapor with nicotine. In addition, platelet derived EVs expressing CD40 ligand was increased after inhalation of e-cigarette vapor without nicotine.

CONCLUSION: As few as 30 puffs of nicotine-containing e-cigarette vapor caused an increase in levels of circulating EVs of endothelial and platelet origin, which may signify underlying vascular changes. Although e-cigarette vapor without nicotine caused an increase in platelet EVs expressing CD40 ligand, nicotine, as a component in the vapor, seems to have a more compelling effect on extracellular vesicle formation and protein composition.

Place, publisher, year, edition, pages
Elsevier, 2020
Keywords
Electronic cigarette, Endothelial microvesicles, Extracellular vesicles, Microparticles, Platelet microvesicles, e-cigarette
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-168670 (URN)10.1016/j.atherosclerosis.2020.02.010 (DOI)32122618 (PubMedID)
Available from: 2020-03-05 Created: 2020-03-05 Last updated: 2020-03-05
Backman, H., Lindberg, A., Hedman, L., Stridsman, C., Jansson, S.-A., Sandström, T., . . . Rönmark, E. (2020). FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort. The World Allergy Organization journal, 13(3), Article ID 100110.
Open this publication in new window or tab >>FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort
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2020 (English)In: The World Allergy Organization journal, ISSN 1939-4551, Vol. 13, no 3, article id 100110Article in journal (Refereed) Published
Abstract [en]

Background: The relationship between lung function decline and eosinophils and neutrophils has important therapeutic implications among asthmatics, but it has rarely been studied in large cohort studies.

Objective: The aim is to study the relationship between blood eosinophils and neutrophils and FEV1 decline in a long-term follow-up of a population-based adult asthma cohort.

Methods: In 2012-2014, an adult asthma cohort was invited to a follow-up including spirometry, blood sampling, and structured interviews, and n = 892 participated (55% women, mean age 59 y, 32-92 y). Blood eosinophils, neutrophils and FEV 1 decline were analyzed both as continuous variables and divided into categories with different cut-offs. Regression models adjusted for smoking, exposure to vapors, gas, dust, or fumes (VGDF), use of inhaled and oral corticosteroids, and other possible confounders were utilized to analyze the relationship between eosinophils and neutrophils at follow-up and FEV1 decline.

Results: The mean follow-up time was 18 years, and the mean FEV 1 decline was 27 ml/year. The annual FEV1 decline was related to higher levels of both blood eosinophils and neutrophils at follow-up, but only the association with eosinophils remained when adjusted for confounders. Further, the association between FEV1 decline and eosinophils was stronger among those using ICS. With EOS <0.3 × 109/L as reference, a more rapid decline in FEV1 was independently related to EOS ≥0.4 × 109/L in adjusted analyses.

Conclusions and clinical relevance: Besides emphasizing the importance of smoking cessation and reduction of other harmful exposures, our real-world results indicate that there is an independent relationship between blood eosinophils and FEV1 decline among adults with asthma.

Place, publisher, year, edition, pages
Elsevier, 2020
Keywords
ANOVA, Analysis of variance, ATS, American Thoracic Society, Asthma, BMI, Body mass index, Cohort, ECRHS, European Community Respiratory Health Survey, EOS, Eosinophils, ERS, European Respiratory Society, Eosinophils, FEV1, FEV1, Forced Expiratory Volume in 1 s, FEV1pp, FEV1 percent of predicted, FVC, Forced Expiratory Volume, GLI, Global Lung function Initiative, ICS, Inhaled corticosteroids, IgE, Immunoglobulin E, L, Liters, Ml, Milliliters, N, Number, NEU, Neutrophils, Neutrophils, OCS, Oral corticosteroids, OLIN, Obstructive Lung Disease in Northern Sweden, OLS, Ordinary Least Squares, VGDF, Vapors, gas, dust or fumes
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-169223 (URN)10.1016/j.waojou.2020.100110 (DOI)32206161 (PubMedID)
Funder
Swedish Heart Lung FoundationSwedish Research CouncilVästerbotten County CouncilNorrbotten County CouncilSwedish Asthma and Allergy AssociationVisare Norr
Available from: 2020-03-26 Created: 2020-03-26 Last updated: 2020-03-27Bibliographically approved
Antoniewicz, L., Brynedal, A., Hedman, L., Lundbäck, M. & Bosson, J. A. (2019). Acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting Airways. Cardiovascular Toxicology, 19(5), 441-450
Open this publication in new window or tab >>Acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting Airways
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2019 (English)In: Cardiovascular Toxicology, ISSN 1530-7905, E-ISSN 1559-0259, Vol. 19, no 5, p. 441-450Article in journal (Refereed) Published
Abstract [en]

The use of electronic cigarettes has increased exponentially since its introduction onto the global market in 2006. However, short- and long-term health effects remain largely unknown due to the novelty of this product. The present study examines the acute effects of e-cigarette aerosol inhalation, with and without nicotine, on vascular and pulmonary function in healthy volunteers. Seventeen healthy subjects inhaled electronic cigarette aerosol with and without nicotine on two separate occasions in a double-blinded crossover fashion. Blood pressure, heart rate, and arterial stiffness measured by pulse wave velocity and pulse wave analysis were assessed at baseline, and then at 0 h, 2 h, and 4 h following exposure. Dynamic spirometry and impulse oscillometry were measured following vascular assessments at these time points, as well as at 6 h following exposure. e-Cigarette aerosol with nicotine caused a significant increase in heart rate and arterial stiffness. Furthermore, e-cigarette aerosol-containing nicotine caused a sudden increase in flow resistance as measured by impulse oscillometry, indicating obstruction of the conducting airways. Both aerosols caused an increase in blood pressure. The present study indicates that inhaled e-cigarette aerosol with nicotine has an acute impact on vascular and pulmonary function. Thus, chronic usage may lead to long-term adverse health effects. Further investigation is warranted.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
Arterial stiffness, Augmentation index, ENDS, Electronic cigarettes, IOS, Pulse wave velocity, e-Cig
National Category
Occupational Health and Environmental Health Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-158824 (URN)10.1007/s12012-019-09516-x (DOI)000486337400006 ()30963443 (PubMedID)
Available from: 2019-05-09 Created: 2019-05-09 Last updated: 2019-11-11Bibliographically approved
Selberg, S., Hedman, L., Jansson, S.-A., Backman, H. & Stridsman, C. (2019). Asthma control and acute health care visits among young adults with asthma: A population-based study. Journal of Advanced Nursing, 75(12), 3525-3534
Open this publication in new window or tab >>Asthma control and acute health care visits among young adults with asthma: A population-based study
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2019 (English)In: Journal of Advanced Nursing, ISSN 0309-2402, E-ISSN 1365-2648, Vol. 75, no 12, p. 3525-3534Article in journal (Refereed) Published
Abstract [en]

AIMS: To study asthma control and acute health care visits among young adults with asthma.

BACKGROUND: Despite the access to effective treatment and nursing interventions, poor asthma control is still common among individuals with asthma. However, studies describing clinical characteristics among young adults with asthma are rare.

DESIGN: A population-based cohort study.

METHODS: In 2015, as a part of the OLIN pediatric cohort I (recruited in 1996 at age 7-8yr), N=2291 young adults (27-28 yr) completed a postal questionnaire survey including questions on asthma and respiratory symptoms. Of these, N=280 (12%) were identified as having current asthma and were further studied.

RESULTS: Of those with current asthma, women reported respiratory symptoms and smoking to a greater extent than men. Approximately one-fourth had uncontrolled asthma and acute health care visits due to asthma was reported by 15% of women and 8% of men. Uncontrolled asthma was associated with smoking, lower educational level, use of reliever treatment most days and acute health care visits. Acute health care visits due to asthma were associated with periodic use of regular controller treatment also after adjustment for uncontrolled asthma.

CONCLUSION: The result indicate poor adherence to asthma treatment which may lead to decreased asthma control and acute health care visits.

IMPACT: Most young adults with asthma are diagnosed and treated in primary care, ideally in a team with a nurse. The main findings highlight the need for evidenced-based nursing interventions, contributing to a more efficient asthma management in primary care. This article is protected by copyright. All rights reserved.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
asthma, health services, nurses, nursing, patient care, primary healthcare, quantitative research, smoking, treatment adherence and compliance, young adult
National Category
Respiratory Medicine and Allergy Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-162645 (URN)10.1111/jan.14174 (DOI)000486799500001 ()31441107 (PubMedID)2-s2.0-85074391870 (Scopus ID)
Available from: 2019-08-26 Created: 2019-08-26 Last updated: 2020-01-09Bibliographically approved
Backman, H., Stridsman, C., Hedman, L., Lindberg, A., Andersson, M., Lundback, B. & Rönmark, E. (2019). Characterization of adults with asthma per GINA treatment steps. Paper presented at European-Respiratory-Society (ERS) International Congress, Madrid, SPAIN, SEP 28-OCT 02, 2019.. European Respiratory Journal, 54
Open this publication in new window or tab >>Characterization of adults with asthma per GINA treatment steps
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2019 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Sheffield: European Respiratory Society Journals, 2019
Keywords
Asthma, Asthma - management, Spirometry
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-168197 (URN)10.1183/13993003.congress-2019.PA4417 (DOI)000507372405429 ()
Conference
European-Respiratory-Society (ERS) International Congress, Madrid, SPAIN, SEP 28-OCT 02, 2019.
Note

Supplement: 63. Meeting Abstract: PA4417.

Available from: 2020-03-11 Created: 2020-03-11 Last updated: 2020-03-11Bibliographically approved
Lassmann-Klee, P., Brumpton, B., Henriksen, A. H., Larsson, M., Sundblad, B.-M., Pölluste, J., . . . Sovijärvi, A. R. A. (2019). Differences of FENO in adult general populations of Nordic regions. Paper presented at European-Respiratory-Society (ERS) International Congress, Madrid, Spain, SEP 28-OCT 02, 2019.. European Respiratory Journal, 54
Open this publication in new window or tab >>Differences of FENO in adult general populations of Nordic regions
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2019 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
European Respiratory Society Journals, 2019
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-168229 (URN)10.1183/13993003.congress-2019.PA5064 (DOI)000507372406418 ()
Conference
European-Respiratory-Society (ERS) International Congress, Madrid, Spain, SEP 28-OCT 02, 2019.
Note

Supplement: 63. Meeting Abstract: PA5064.

Available from: 2020-02-20 Created: 2020-02-20 Last updated: 2020-02-20Bibliographically approved
Hedman, L., Backman, H., Stridsman, C., Lindberg, A., Lundback, B. & Rönmark, E. (2019). E-cigarette use is most common in persistent smokers in a Swedish prospective population study. Paper presented at European-Respiratory-Society (ERS) International Congress, Madrid, SPAIN, SEP 28-OCT 02, 2019.. European Respiratory Journal, 54
Open this publication in new window or tab >>E-cigarette use is most common in persistent smokers in a Swedish prospective population study
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2019 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Sheffield: European Respiratory Society Journals, 2019
Keywords
Adults, Smoking
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-168191 (URN)10.1183/13993003.congress-2019.OA3313 (DOI)000507372400230 ()
Conference
European-Respiratory-Society (ERS) International Congress, Madrid, SPAIN, SEP 28-OCT 02, 2019.
Note

Supplement: 63. Meeting Abstract: OA3313.

Available from: 2020-03-12 Created: 2020-03-12 Last updated: 2020-03-12Bibliographically approved
Lagrange, E., Nilsson, U., Hedman, L., Stridsman, C., Backman, H., Lindberg, A. & Blomberg, A. (2019). Elevated hsCRP is associated with respiratory symptoms in COPD. Paper presented at European-Respiratory-Society (ERS) International Congress, Madrid, Spain, SEP 28-OCT 02, 2019.. European Respiratory Journal, 54
Open this publication in new window or tab >>Elevated hsCRP is associated with respiratory symptoms in COPD
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2019 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Sheffield: European Respiratory Society Journals, 2019
Keywords
COPD, Biomarkers, Inflammation
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-168221 (URN)10.1183/13993003.congress-2019.PA4430 (DOI)000507372405441 ()
Conference
European-Respiratory-Society (ERS) International Congress, Madrid, Spain, SEP 28-OCT 02, 2019.
Note

Supplement: 63. Meeting Abstract: PA4430.

Available from: 2020-02-26 Created: 2020-02-26 Last updated: 2020-02-26Bibliographically approved
Pisinger, C., Dagli, E., Filippidis, F. T., Hedman, L., Janson, C., Loukides, S., . . . Vestbo, J. (2019). ERS and tobacco harm reduction. European Respiratory Journal, 54(6), Article ID 1902009.
Open this publication in new window or tab >>ERS and tobacco harm reduction
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2019 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54, no 6, article id 1902009Article in journal, Editorial material (Other academic) Published
Place, publisher, year, edition, pages
European Respiratory Society, 2019
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-167356 (URN)10.1183/13993003.02009-2019 (DOI)000505226200031 ()31801824 (PubMedID)2-s2.0-85076006834 (Scopus ID)
Available from: 2020-01-22 Created: 2020-01-22 Last updated: 2020-01-22Bibliographically approved
Jansson, S.-A., Hedman, L., Stridsman, C., Axelsson, M., Kriit, H. K., Lindberg, A., . . . Backman, H. (2019). Life-years lost due to asthma. Paper presented at European-Respiratory-Society (ERS) International Congress, Madrid, SPAIN, SEP 28-OCT 02, 2019.. European Respiratory Journal, 54
Open this publication in new window or tab >>Life-years lost due to asthma
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2019 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Sheffield: European Respiratory Society Journals, 2019
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:umu:diva-168184 (URN)10.1183/13993003.congress-2019.PA5063 (DOI)000507372406417 ()
Conference
European-Respiratory-Society (ERS) International Congress, Madrid, SPAIN, SEP 28-OCT 02, 2019.
Note

Supplement: 63. Meeting Abstract: PA5063.

Available from: 2020-03-12 Created: 2020-03-12 Last updated: 2020-03-12Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0002-1630-3167

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