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Ahlqvist, Jan
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Gustafsson, N., Ahlqvist, J., Näslund, U., Buhlin, K., Gustafsson, A., Kjellström, B., . . . Levring Jäghagen, E. (2020). Associations among Periodontitis, Calcified Carotid Artery Atheromas, and Risk of Myocardial Infarction. Journal of Dental Research, 99(1), 60-68
Åpne denne publikasjonen i ny fane eller vindu >>Associations among Periodontitis, Calcified Carotid Artery Atheromas, and Risk of Myocardial Infarction
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2020 (engelsk)Inngår i: Journal of Dental Research, ISSN 0022-0345, E-ISSN 1544-0591, Vol. 99, nr 1, s. 60-68Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Cardiovascular disease is a common cause of morbidity and premature mortality. Cardiovascular disease can be prevented when risk factors are identified early. Calcified carotid artery atheromas (CCAAs), detected in panoramic radiographs, and periodontitis have both been associated with increased risk of cardiovascular disease. This case-control study aimed to 1) investigate associations between periodontitis and CCAA detected in panoramic radiographs and 2) determine the risk of future myocardial infarctions due to CCAA combined with periodontitis. We evaluated 1,482 participants (738 cases and 744 controls) with periodontitis and CCAAs recruited from the PAROKRANK study (Periodontitis and Its Relation to Coronary Artery Disease). Participants were examined with panoramic radiographs, including the carotid regions. Associations between myocardial infarction and periodontitis combined with CCAA were evaluated in 696 cases and 696 age-, sex-, and residential area-matched controls. Periodontitis was evaluated radiographically (as degree of bone loss) and with a clinical periodontal disease index score (from clinical and radiographic assessments). We found associations between CCAA and clinical periodontal disease index score among cases (odds ratio [OR], 1.51; 95% CI, 1.09 to 2.10; P = 0.02) and controls (OR, 1.70; 95% CI, 1.22 to 2.38; P < 0.01), although not between CCAA and the degree of bone loss. In a multivariable model, myocardial infarction was associated with CCAA combined with periodontitis, as assessed by degree of bone loss (OR, 1.75; 95% CI, 1.11 to 2.74; P = 0.01). When the cohort was stratified by sex, only men showed a significant association between myocardial infarction and CCAA combined with periodontitis. Participants with clinically diagnosed periodontitis exhibited CCAA in panoramic radiographs more often than those without periodontitis, irrespective of the presence of a recent myocardial infarction. Participants with combined periodontitis and CCAA had a higher risk of having had myocardial infarction as compared with participants with either condition alone. These findings implied that patients in dental care might benefit from dentists assessing panoramic radiographs for CCAA-particularly, patients with periodontitis who have not received any preventive measures for cardiovascular disease.

sted, utgiver, år, opplag, sider
Sage Publications, 2020
Emneord
carotid artery atherosclerosis, cardiovascular disease(s), inflammation, radiography, risk factor(s), gender differences
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-165744 (URN)10.1177/0022034519885362 (DOI)000497086100001 ()31702950 (PubMedID)2-s2.0-85075189166 (Scopus ID)
Forskningsfinansiär
The Kempe FoundationsVästerbotten County Council
Tilgjengelig fra: 2019-12-10 Laget: 2019-12-10 Sist oppdatert: 2020-01-08bibliografisk kontrollert
Garoff, M., Ahlqvist, J., Edin, L.-T., Jensen, S., Levring Jäghagen, E., Petäjäniemi, F., . . . Johansson, E. (2019). Bilateral vessel-outlining carotid artery calcifications in panoramic radiographs: an independent risk marker for vascular events. BMC Cardiovascular Disorders, 19(1), Article ID 225.
Åpne denne publikasjonen i ny fane eller vindu >>Bilateral vessel-outlining carotid artery calcifications in panoramic radiographs: an independent risk marker for vascular events
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2019 (engelsk)Inngår i: BMC Cardiovascular Disorders, ISSN 1471-2261, E-ISSN 1471-2261, Vol. 19, nr 1, artikkel-id 225Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: In odontology, panoramic radiographs (PRs) are regularly performed. PRs depict the teeth and jaws as well as carotid artery calcifications (CACs). Patients with CACs on PRs have an increased risk of vascular events compared to healthy controls without CACs, but this association is often caused by more vascular events and risk factors at baseline. However, the risk of vascular events has only been analyzed based on the presence of CACs, and not their shape. Thus, this study determined if the shape of CACs in PRs affects the risk of future vascular events.

METHODS: The study cohort included 117 consecutive patients with CACs in PRs and 121 age-matched controls without CACs. CAC shape in PRs was dichotomized into bilateral vessel-outlining CACs and other CAC shapes. Participants were followed prospectively for an endpoint of vascular events including myocardial infarction, stroke, and vascular death.

RESULTS: Patients with bilateral vessel-outlining CACs had more previous vascular events than those with other CAC shapes and the healthy controls (p < 0.001, χ2). The mean follow-up duration was 9.5 years. The endpoint was reached in 83 people. Patients with bilateral vessel-outlining CACs had a higher annual risk of vascular events (7.0%) than those with other CAC shapes (4.4%) and the controls (2.6%) (p < 0.001). In multivariate analysis, bilateral vessel-outlining CACs (hazard ratio: 2.2, 95% confidence interval: 1.1-4.5) were independent risk markers for the endpoint.

CONCLUSIONS: Findings of bilateral vessel-outlining CACs in PRs are independent risk markers for future vascular events.

sted, utgiver, år, opplag, sider
BioMed Central, 2019
Emneord
Cardiovascular disease, Carotid atherosclerosis, Panoramic radiography
HSV kategori
Forskningsprogram
medicin; odontologi
Identifikatorer
urn:nbn:se:umu:diva-164795 (URN)10.1186/s12872-019-1211-3 (DOI)000490832600004 ()31619183 (PubMedID)
Forskningsfinansiär
Swedish Heart Lung FoundationVästerbotten County CouncilKnut and Alice Wallenberg Foundation
Tilgjengelig fra: 2019-11-01 Laget: 2019-11-01 Sist oppdatert: 2019-11-19bibliografisk kontrollert
Gustafsson, N., Ahlqvist, J. & Levring Jäghagen, E. (2019). Long-term skill improvement among general dental practitioners after a short training programme in diagnosing calcified carotid artery atheromas on panoramic radiographs. European journal of dental education, 23, 54-61
Åpne denne publikasjonen i ny fane eller vindu >>Long-term skill improvement among general dental practitioners after a short training programme in diagnosing calcified carotid artery atheromas on panoramic radiographs
2019 (engelsk)Inngår i: European journal of dental education, ISSN 1396-5883, E-ISSN 1600-0579, Vol. 23, s. 54-61Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

PURPOSE: To study general dental practitioners (GDPs) ability to detect calcified carotid artery atheromas (CCAAs) in panoramic radiographs (PRs) and if their diagnostic accuracy in long term is improved after a short training programme.

METHODS: Fourteen GDPs had their diagnostic accuracy regarding CCAA in PR assessed at baseline, 2 weeks and 1 year after training. Comparison was made with a reference standard based on consensus results from two experienced oral and maxillofacial radiologists. At each session, 100 radiographs were assessed individually by the GDPs. After the baseline assessment, the GDPs participated in a 2-hour training programme comprising a lecture and diagnostic training by calibration. The GDPs results before and after training were compared, as well as between follow-up sessions.

RESULTS: A significant improvement in diagnostic accuracy was observed with increased sensitivity (from 41.8% to 55.7%, P = 0.02) without a significant decrease in specificity (from 87.2% to 86.7%, P = 0.87). The Kappa values also increased (from 0.66 to 0.71, P = 0.04). At 1-year follow-up, the improvement compared to baseline remained significant. There were no significant changes between the 2-week and 1-year follow-up assessment.

CONCLUSION: A short training programme can significantly and sustainable improve GDPs diagnostic accuracy regarding CCAA.

sted, utgiver, år, opplag, sider
Wiley-Blackwell, 2019
Emneord
calcified carotid artery atheroma, carotid artery calcification, education, panoramic radiography, radiology
HSV kategori
Forskningsprogram
radiologi; odontologi; pedagogik
Identifikatorer
urn:nbn:se:umu:diva-153768 (URN)10.1111/eje.12402 (DOI)000455041100015 ()30358024 (PubMedID)2-s2.0-85056352070 (Scopus ID)
Tilgjengelig fra: 2018-12-01 Laget: 2018-12-01 Sist oppdatert: 2019-05-20bibliografisk kontrollert
Lundberg, E., Strandberg Mihajlovic, N., Sjöström, M. & Ahlqvist, J. B. (2019). The use of panoramic images for identification of edentulous persons. Journal of Forensic Odonto-Stomatology, 37(2), 18-24
Åpne denne publikasjonen i ny fane eller vindu >>The use of panoramic images for identification of edentulous persons
2019 (engelsk)Inngår i: Journal of Forensic Odonto-Stomatology, ISSN 0258-414X, E-ISSN 2219-6749, Vol. 37, nr 2, s. 18-24Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The aim of this study was to determine if edentulous persons could be identified using panoramic images by: I) investigating the possibility of matching two panoramic radiographs of the same person obtained on two different occasions, II) determining what anatomical features are used as the base for matching, III) investigating if oral and maxillofacial radiologists (OMR) and dentists who were not oral and maxillofacial radiologists (NOMR) differed in their ability to match the images, and IV) determining if the time elapsed between the images affected the results or the confidence of the match. Panoramic image pairs from 19 patients obtained on two different occasions were included, plus 10 images from other edentulous patients. The time elapsed between the image pairs varied between 4 months and 6 years. Four OMR and four NOMR were asked to match the image pairs depicting the same patient. The participants marked each match as "certain", "likely", or "possible" and what anatomical structure they used for matching. The OMR group correctly matched 100% of the images and the NOMR group correctly matched 96%. The anatomy of the mandible was most often used for matching. The OMR group was more certain in their decisions than the NOMR group. The time elapsed between the examinations did not affect the result. In conclusion, panoramic images can be used to identify edentulous patients. Both OMR and NOMR could identify edentulous individuals when only panoramic radiographic images were available and the OMR were especially confident in the identification process.

sted, utgiver, år, opplag, sider
International Organization for Forensic Odonto-Stomatology, 2019
Emneord
Forensic odontology, Panoramic radiography, Identification, Edentulous patients
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-165058 (URN)31589592 (PubMedID)
Tilgjengelig fra: 2019-11-07 Laget: 2019-11-07 Sist oppdatert: 2019-11-19bibliografisk kontrollert
Gustafsson, N., Ahlqvist, J. B., Näslund, U., Wester, P., Buhlin, K., Gustafsson, A. & Levring Jäghagen, E. (2018). Calcified carotid artery atheromas in panoramic radiographs are associated with a first myocardial infarction: a case-control study. Oral surgery, oral medicine, oral pathology and oral radiology, 125(2), 199-205
Åpne denne publikasjonen i ny fane eller vindu >>Calcified carotid artery atheromas in panoramic radiographs are associated with a first myocardial infarction: a case-control study
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2018 (engelsk)Inngår i: Oral surgery, oral medicine, oral pathology and oral radiology, ISSN 2212-4403, E-ISSN 2212-4411, Vol. 125, nr 2, s. 199-205Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective. The aim of this case-control study was to investigate whether patients with a first myocardial infarction (MI) had a higher prevalence of calcified carotid artery atheromas (CCAAs) on panoramic radiographs (PRs) than age-, gender-, and residential area-matched controls without MI. Study Design. Six hundred ninety-six cases with a first MI and 696 controls were included in this substudy of the Swedish multicentre PAROKRANK study. All participants underwent panoramic radiography, and the PRs were evaluated for CCAAs. Results. The prevalence of CCAAs detected by PR was 33.8% (235 of 696) in cases and 27.6% (192 of 696) in controls (odds ratio [OR] 1.24; 95% confidence interval [CI] 1.04-1.44; P = .012). Among males, 32.7% of cases (184 of 562) and 26.5% of controls (149 of 562) displayed CCAAs on PRs (OR 1.24; 95% CI 1.03-1.48; P = .022). Among both genders, bilateral CCAAs were significantly more common among cases than among controls (P = .002). Conclusions. Cases with recent MIs had a significantly higher prevalence of CCAAs on PRs compared with controls without MIs. This difference between groups was more pronounced for bilateral CCAAs. These findings supported the hypothesis that CCAA detection could serve as a risk indicator for future MIs.

sted, utgiver, år, opplag, sider
ELSEVIER SCIENCE INC, 2018
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-144341 (URN)10.1016/j.oooo.2017.10.009 (DOI)000422751700018 ()29242130 (PubMedID)
Tilgjengelig fra: 2018-02-08 Laget: 2018-02-08 Sist oppdatert: 2019-05-21bibliografisk kontrollert
Garoff, M., Ahlqvist, J., Levring Jäghagen, E., Johansson, E. & Wester, P. (2016). Carotid calcification in panoramic radiographs: radiographic appearance and the degree of carotid stenosis. Dento-Maxillo-Facial Radiology, 45(6), Article ID 20160147.
Åpne denne publikasjonen i ny fane eller vindu >>Carotid calcification in panoramic radiographs: radiographic appearance and the degree of carotid stenosis
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2016 (engelsk)Inngår i: Dento-Maxillo-Facial Radiology, ISSN 0250-832X, E-ISSN 1476-542X, Vol. 45, nr 6, artikkel-id 20160147Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objectives: Approximately 7% of patients examined with panoramic radiographs (PRs) for odontological reasons, and with incidental findings of carotid artery calcification (CAC), have significant (≥50%) carotid stenosis (SCS). The aim of this study was to determine if the radiographic appearance of CACs in PRs could be categorized such that we could improve the positive-predictive value (PPV) for SCS detection.

Methods: This cross-sectional study included 278 patients with CACs identified by PRs, 127 with SCS and 151 without SCS. CACs were categorized based on the following appearances: (1) single, (2) scattered or (3) vessel-outlining. Correlates were derived for each category according to positivity or not for SCS in the corresponding neck sides. For a representative adult population (in dentistry) presenting with CACs in PRs, PPVs for SCS prediction were then calculated for three subgroups based on different combinations of appearances (2) and/or (3).

Results: Vessel-outlining CACs corresponded to 65% of neck sides with SCS vs 47% without SCS (p < 0.001). Single CACs corresponded to 15% of neck sides with SCS vs 27% without SCS (p = 0.006). Scattered CACs corresponded to 20% of neck sides with SCS vs 26% without SCS (p  = 0.127). In the representative population, the PPVs for SCS detection were comparable (7.2–7.8%) for all three subgroups and when the presence of a CAC is the sole criterion (7.4%).

Conclusions: Stratifying the radiographic appearance of CACs in PRs does not improve the PPV for SCS detection. Whether different radiographic appearances are associated with future risk of stroke, or other cardiovascular events, remains unknown.

sted, utgiver, år, opplag, sider
British Institute of Radiology, 2016
Emneord
carotid stenosis, panoramic radiography, calcification
HSV kategori
Forskningsprogram
odontologi
Identifikatorer
urn:nbn:se:umu:diva-119791 (URN)10.1259/dmfr.20160147 (DOI)000381711400003 ()
Merknad

First published in theses in manuscript form.

Tilgjengelig fra: 2016-04-27 Laget: 2016-04-27 Sist oppdatert: 2018-06-07bibliografisk kontrollert
Johansson, J., Bladh, M., Sjöström, M. & Ahlqvist, J. (2016). The use of intraoral radiographs for identification of edentulous patients rehabilitated with implants. Journal of Forensic Odonto-Stomatology, 34(1), 1-9
Åpne denne publikasjonen i ny fane eller vindu >>The use of intraoral radiographs for identification of edentulous patients rehabilitated with implants
2016 (engelsk)Inngår i: Journal of Forensic Odonto-Stomatology, ISSN 0258-414X, E-ISSN 2219-6749, Vol. 34, nr 1, s. 1-9Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The aims of this study were; i) to determine the accuracy by which two intra-oral radiographic examinations performed on patients with edentulous mandibles treated with dental implants can be matched. ii) to determine whether prosthodontic supra-construction is important for matching. iii) to investigate whether there is a difference between oral and maxilla-facial radiologists (OMR) and dental practitioners, not specialized in oral and maxillofacial radiology (NOMR), regarding their ability to match. The specific features of the radiographs used by the operators to acquire a match were also investigated. Intra-oral radiographic examinations from 59 patients were utilized. Radiographic examinations from 47 patients carried out at placement of the supra-construction and at subsequent follow-up examinations were used as "ante-mortem" and "post-mortem" records respectively. Examinations from 12 patients were added to the "post-mortem" records without "ante-mortem" records being available. The study was divided into two parts. In Part One all "ante"- and "post-mortem" records had the supra-construction masked and in Part Two it was visible. Seven dentists (4 OMR, 3 NOMR) were instructed to specify on what basis each matching was made on the confidence of a three-graded scale OMR had 93.2 % and 98.5 % accuracy in Parts One and Two respectively. NOMR had 63.8 % and 87.9 %. Bone anatomy was the most commonly used feature by OMR to obtain a match. For NOMR it was the appearance of the fixtures. OMR reported higher confidence in their ability to match the examinations. This study indicates that OMR could be a valuable resource in cases of identification where dental implants are a feature of the post-mortem dental records.

Emneord
dental identification, forensic odontology, dental implants, intra-oral radiographs, edentulous patients
HSV kategori
Forskningsprogram
rättsmedicin; odontologi; radiologi
Identifikatorer
urn:nbn:se:umu:diva-125216 (URN)
Tilgjengelig fra: 2016-09-08 Laget: 2016-09-08 Sist oppdatert: 2018-06-07bibliografisk kontrollert
Jashari, F., Ibrahimi, P., Johansson, E., Ahlqvist, J., Arnerlöv, C., Garoff, M., . . . Henein, M. Y. (2015). Atherosclerotic Calcification Detection: A Comparative Study of Carotid Ultrasound and Cone Beam CT. International Journal of Molecular Sciences, 16(8), 19978-19988
Åpne denne publikasjonen i ny fane eller vindu >>Atherosclerotic Calcification Detection: A Comparative Study of Carotid Ultrasound and Cone Beam CT
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2015 (engelsk)Inngår i: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 16, nr 8, s. 19978-19988Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND AND AIM: Arterial calcification is often detected on ultrasound examination but its diagnostic accuracy is not well validated. The aim of this study was to determine the accuracy of carotid ultrasound B mode findings in detecting atherosclerotic calcification quantified by cone beam computed tomography (CBCT).

METHODS: We analyzed 94 carotid arteries, from 88 patients (mean age 70 ± 7 years, 33% females), who underwent pre-endarterectomy ultrasound examination. Plaques with high echogenic nodules and posterior shadowing were considered calcified. After surgery, the excised plaques were examined using CBCT, from which the calcification volume (mm3) was calculated. In cases with multiple calcifications the largest calcification nodule volume was used to represent the plaque. Carotid artery calcification by the two imaging techniques was compared using conventional correlations.

RESULTS: Carotid ultrasound was highly accurate in detecting the presence of calcification; with a sensitivity of 88.2%. Based on the quartile ranges of calcification volumes measured by CBCT we have divided plaque calcification into four groups: <8; 8-35; 36-70 and >70 mm3. Calcification volumes ≥8 were accurately detectable by ultrasound with a sensitivity of 96%. Of the 21 plaques with <8 mm3 calcification volume; only 13 were detected by ultrasound; resulting in a sensitivity of 62%. There was no difference in the volume of calcification between symptomatic and asymptomatic patients.

CONCLUSION: Carotid ultrasound is highly accurate in detecting the presence of calcified atherosclerotic lesions of volume ≥8 mm3; but less accurate in detecting smaller volume calcified plaques. Further development of ultrasound techniques should allow better detection of early arterial calcification.

sted, utgiver, år, opplag, sider
MDPI, 2015
Emneord
carotid atherosclerosis, ultrasound, calcification
HSV kategori
Forskningsprogram
medicin, hjärt- och kärlforskning; odontologi; radiologi
Identifikatorer
urn:nbn:se:umu:diva-107990 (URN)10.3390/ijms160819978 (DOI)000366826100173 ()26307978 (PubMedID)
Tilgjengelig fra: 2015-08-31 Laget: 2015-08-31 Sist oppdatert: 2018-06-07bibliografisk kontrollert
Garoff, M., Johansson, E., Ahlqvist, J., Arnerlöv, C., Levring Jäghagen, E. & Wester, P. (2015). Calcium quantity in carotid plaques: detection in panoramic radiographs and association with degree of stenosis. Oral surgery, oral medicine, oral pathology and oral radiology, 120(2), 269-274
Åpne denne publikasjonen i ny fane eller vindu >>Calcium quantity in carotid plaques: detection in panoramic radiographs and association with degree of stenosis
Vise andre…
2015 (engelsk)Inngår i: Oral surgery, oral medicine, oral pathology and oral radiology, ISSN 2212-4403, E-ISSN 2212-4411, Vol. 120, nr 2, s. 269-274Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

OBJECTIVE: To determine calcium volume in extirpated carotid plaques, analyze correlations between calcium volume and degree of stenosis, and analyze whether calcium volume influences the possibility of detecting stenosis in panoramic radiographs.

STUDY DESIGN: Ninety-seven consecutive patients with ultrasonography-verified carotid stenosis were examined with panoramic radiography before surgery. Extirpated carotid plaques (n = 103) were analyzed for calcium volume by cone beam computed tomography (CBCT). Panoramic radiographs were analyzed for carotid calcifications.

RESULTS: The median calcium volume was 45 mm(3) (first quartile subtracted from the third quartile [IQR], 14-98 mm(3)). We observed no correlation between calcium volume and degree of stenosis. Seventy-eight stenoses were situated within the region included in the panoramic radiographs, and their volumes ranged from 0 to 509 mm(3). Of these, 99% revealed carotid calcifications on panoramic radiographs.

CONCLUSIONS: We found no association between calcium volume and degree of carotid stenosis. Calcium volume did not influence the possibility of detecting carotid calcifications in panoramic radiographs.

HSV kategori
Forskningsprogram
odontologi; radiologi; medicin, hjärt- och kärlforskning
Identifikatorer
urn:nbn:se:umu:diva-107590 (URN)10.1016/j.oooo.2015.04.010 (DOI)000360302600022 ()26166031 (PubMedID)
Tilgjengelig fra: 2015-08-25 Laget: 2015-08-24 Sist oppdatert: 2018-06-07bibliografisk kontrollert
Johansson, E., Ahlqvist, J., Garoff, M., Levring Jäghagen, E., Meimermondt, A. & Wester, P. (2015). Carotid calcifications on panoramic radiographs: a 5-year follow-up study. Oral surgery, oral medicine, oral pathology and oral radiology, 120(4), 513-520
Åpne denne publikasjonen i ny fane eller vindu >>Carotid calcifications on panoramic radiographs: a 5-year follow-up study
Vise andre…
2015 (engelsk)Inngår i: Oral surgery, oral medicine, oral pathology and oral radiology, ISSN 2212-4403, E-ISSN 2212-4411, Vol. 120, nr 4, s. 513-520Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective. The aim of this study was to determine whether people with calcifications in the area of the carotid arteries on panoramic radiographs (CALPANs) have an increased prevalence of vascular risk factors or an increased risk of future vascular events. Materials and Methods. We included 113 consecutive patients with CALPANs and 116 gender- and age-matched controls without CALPANs. Vascular risk factors were generally known in the study population, since it was recorded in a population-based community-screening program. Results. Patients with CALPANs had a higher prevalence of vascular risk factors than controls independent of previous vascular events. During the 5.4-year follow-up, patients with CALPANs had a higher risk of a combined endpoint of vascular events (5.6%/yr) compared with the controls (2.4%/yr) (P = .004 by log rank test; unadjusted hazard ratio (HR) 2.4; 95% CI 1.3-4.3). This difference was not significant when previous vascular events and risk factors were taken into account (adjusted HR; 1.2; 95% CI 0.6-2.3; P = .62; Cox regression). Conclusions. People with CALPANs are very likely to have vascular risk factors, but these factors might be unknown when CALPANs are detected. Accordingly, patients with CALPANs should be advised to have their vascular risk factors regularly checked in order to receive advice on preventive lifestyle modifications and medical treatment when indicated. However, it remains unknown whether CALPANs add information about the independent risk of future vascular events. Therefore, further studies are warranted to investigate whether the detection of CALPANs indicates a need for additional or more intense vascular treatment.

sted, utgiver, år, opplag, sider
[Johansson, Elias; Meimermondt, Amanda] Umea Univ, Dept Pharmacol & Clin Neurosci, S-90182 ea, Sweden. [Johansson, Elias; Wester, Per] Umea Univ, Dept Publ Hlth & Clin Med, S-90182 Umea, Sweden. [Ahlqvist, Jan; Garoff, Maria; Jaghagen, Eva Levring] Umea Univ, Dept Odontol, S-90182 Umea, Sweden.: , 2015
Emneord
vascular risk, cardiology
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-109796 (URN)10.1016/j.oooo.2015.06.026 (DOI)000360912000015 ()26260766 (PubMedID)
Tilgjengelig fra: 2015-10-08 Laget: 2015-10-06 Sist oppdatert: 2018-06-07bibliografisk kontrollert
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