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Boraxbekk, Carl-JohanORCID iD iconorcid.org/0000-0002-4458-6475
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Publikasjoner (10 av 108) Visa alla publikasjoner
Frykholm, E., Simonsson, E., Levik Sandström, S., Hedlund, M., Holmberg, H., Johansson, B., . . . Rosendahl, E. (2024). Applicability of a supramaximal high-intensity interval training program for older adults previously not engaged in regular exercise: analyses of secondary outcomes from the Umeå HIT Study. Psychology of Sport And Exercise, 73, Article ID 102647.
Åpne denne publikasjonen i ny fane eller vindu >>Applicability of a supramaximal high-intensity interval training program for older adults previously not engaged in regular exercise: analyses of secondary outcomes from the Umeå HIT Study
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2024 (engelsk)Inngår i: Psychology of Sport And Exercise, ISSN 1469-0292, E-ISSN 1878-5476, Vol. 73, artikkel-id 102647Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

This analysis of secondary outcomes investigated the applicability of supramaximal high-intensity interval training (HIT) with individually prescribed external intensity performed on stationary bicycles. Sixty-eight participants with a median (min; max) age of 69 (66; 79), at the time not engaged in regular exercise were randomized to 25 twice-weekly sessions of supramaximal HIT (20-min session with 10 × 6-s intervals) or moderate-intensity training (MIT, 40-min session with 3 × 8-min intervals). The primary aim was outcomes on applicability regarding; adherence to prescribed external interval intensity, participant reported positive and negative events, ratings of perceived exertion (RPE 6–20), and affective state (Feeling Scale, FS -5–5). A secondary aim was to investigate change in exercise-related self-efficacy (Exercise Self-Efficacy Scale) and motivation (Behavioural Regulations in Exercise Questionnaire-2). Total adherence to the prescribed external interval intensity was [median (min; max)] 89 % (56; 100 %) in supramaximal HIT, and 100 % (95; 100 %) in MIT. The supramaximal HIT group reported 60 % of the positive (112 of 186) and 36 % of the negative (52 of 146) events. At the end of the training period, the median (min; max) session RPE was 15 (12; 17) for supramaximal HIT and 14 (9; 15) for MIT. As for FS, the median last within-session rating was 3 (−1; 5) for supramaximal HIT and 3 (1; 5) for MIT. Exercise-related motivation increased (mean difference in Relative Autonomy Index score = 1.54, 95 % CI [0.69; 2.40]), while self-efficacy did not change (mean difference = 0.55, 95 % CI [-0.75; 1.82]), regardless of group. This study provide support for supramaximal HIT in supervised group settings for older adults.

sted, utgiver, år, opplag, sider
Elsevier, 2024
Emneord
Feasibility, HIIT, Randomized controlled trial, SIT, Sprint interval training
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-223607 (URN)10.1016/j.psychsport.2024.102647 (DOI)38604572 (PubMedID)2-s2.0-85190305065 (Scopus ID)
Forskningsfinansiär
Swedish Research Council, 2017–00912Forte, Swedish Research Council for Health, Working Life and Welfare, 2020–00159The Kamprad Family FoundationThe Dementia Association - The National Association for the Rights of the DementedFoundation for the Memory of Ragnhild and Einar LundströmThe Kempe Foundations
Tilgjengelig fra: 2024-05-02 Laget: 2024-05-02 Sist oppdatert: 2024-07-02bibliografisk kontrollert
Aronsson, I., Neely, A. S., Boraxbekk, C.-J., Eskilsson, T. & Gavelin, H. M. (2024). "Recovery activities are needed every step of the way": exploring the process of long-term recovery in people previously diagnosed with exhaustion disorder. BMC Psychology, 12(1), Article ID 248.
Åpne denne publikasjonen i ny fane eller vindu >>"Recovery activities are needed every step of the way": exploring the process of long-term recovery in people previously diagnosed with exhaustion disorder
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2024 (engelsk)Inngår i: BMC Psychology, E-ISSN 2050-7283, Vol. 12, nr 1, artikkel-id 248Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Sick-leave rates are high due to stress-related illnesses, but little is still known about the process of recovery from these conditions. The aim of this study was to explore the experiences of the recovery process, 6 to 10 years after treatment in people previously diagnosed with exhaustion disorder (ED), focusing on facilitators and barriers for the process of recovery from ED, and recovery activities experienced as helpful during the recovery process.

Method: Thirty-eight participants (average age: 52 years, 32 females) previously diagnosed with ED were interviewed with semi-structured interviews 6–10 years after undergoing treatment. The interviews were analyzed with thematic analysis.

Results: Three themes resulted from the analysis. The first theme, “A long and rocky road”, summarizes the fluctuating path to feeling better and emphasizes barriers and facilitators that affected the process of recovery, with a focus on external life events and the participants’ own behaviors. Facilitators were changing workplace, receiving support, a reduction in stressors, and changed behaviors. Barriers were a poor work environment, caregiver responsibilities, negative life events and lack of support. The second theme “Recovery activities are needed every step of the way” describes how both the need for recovery activities and the types of activities experienced as helpful changed during the recovery process, from low-effort recovery activities for long periods of time to shorter and more active recovery activities. Recovery activities were described as important for self-care but hard to prioritize in everyday life. The last theme, “Reorienting to a new place”, captures the struggle to cope with the remaining impact of ED, and how internal facilitators in terms of understanding and acceptance were important to reorient and adjust to a new way of functioning.

Conclusions: Recovering from ED is a long and ongoing process where recovery activities are needed every step of the way. Our results highlight the importance of supporting personal recovery and long-term behavioral change, addressing individual stressors that may perpetuate the condition, and adjusting recovery activities according to where the person is in the recovery process.

Trial registration: ClinicalTrials.gov: NCT0073772. Registered on March 8, 2017. This study was pre-registered on Open Science Framework (osf.io).

sted, utgiver, år, opplag, sider
BioMed Central (BMC), 2024
Emneord
Clinical burnout, Exhaustion disorder, Recovery activities, Recovery process
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-224236 (URN)10.1186/s40359-024-01756-z (DOI)001214797700001 ()38711137 (PubMedID)2-s2.0-85192161955 (Scopus ID)
Forskningsfinansiär
AFA Insurance, 150175Forte, Swedish Research Council for Health, Working Life and Welfare, 2020–01111
Tilgjengelig fra: 2024-05-15 Laget: 2024-05-15 Sist oppdatert: 2024-05-15bibliografisk kontrollert
Sandberg, P., Boraxbekk, C.-J., Zogaj, I. & Nyberg, L. (2023). Age-independent transfer after successful associative mnemonic training. Journal of Cognitive Enhancement, 7(3-4), 159-172
Åpne denne publikasjonen i ny fane eller vindu >>Age-independent transfer after successful associative mnemonic training
2023 (engelsk)Inngår i: Journal of Cognitive Enhancement, ISSN 2509-3290, Vol. 7, nr 3-4, s. 159-172Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Generalization of training to support the performance on new tasks—transfer—has been much studied. One hypothesis is that transfer occurs if overlapping neuronal circuits are engaged in both training and transfer tasks. Here, we investigated transfer effects in the domain of episodic memory by following 356 participants between 20 and 83 years who downloaded and used a smart phone application to practice the method of loci (MoL) over 3 months. We measured transfer of MoL training to three associative memory tasks with hypothesized neurocognitive overlap (binding in the hippocampus) with the trained task. Transfer tasks were administered at the beginning of training and when two specific proficiency levels in Loci training were reached. Results showed robust transfer effects across the age span at both levels. These results indicate that app-based strategy training can lead to enhancement of episodic memory beyond the specific training task, which may have clinical implementations.

sted, utgiver, år, opplag, sider
Springer Nature, 2023
Emneord
Aging, Episodic memory training, Mnemonics, Strategy training, The method of loci, Transfer effects
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-215935 (URN)10.1007/s41465-023-00273-y (DOI)001087509300001 ()2-s2.0-85174607278 (Scopus ID)
Forskningsfinansiär
Knut and Alice Wallenberg Foundation, 2015.0277
Tilgjengelig fra: 2023-11-02 Laget: 2023-11-02 Sist oppdatert: 2024-01-11bibliografisk kontrollert
Demnitz, N., Hulme, O. J., Siebner, H. R., Kjaer, M., Ebmeier, K. P., Boraxbekk, C.-J. & Gillan, C. M. (2023). Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts. Neurobiology of Aging, 131, 115-123
Åpne denne publikasjonen i ny fane eller vindu >>Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts
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2023 (engelsk)Inngår i: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 131, s. 115-123Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Modifiable lifestyle factors have been shown to promote healthy brain ageing. However, studies have typically focused on a single factor at a time. Given that lifestyle factors do not occur in isolation, multivariable analyses provide a more realistic model of the lifestyle-brain relationship. Here, canonical correlation analyses (CCA) examined the relationship between nine lifestyle factors and seven MRI-derived indices of brain structure. The resulting covariance pattern was further explored with Bayesian regressions. CCA analyses were first conducted on a Danish cohort of older adults (n = 251) and then replicated in a British cohort (n = 668). In both cohorts, the latent factors of lifestyle and brain structure were positively correlated (UK: r =.37, p < 0.001; Denmark: r =.27, p < 0.001). In the cross-validation study, the correlation between lifestyle-brain latent factors was r =.10, p = 0.008. However, the pattern of associations differed between datasets. These findings suggest that baseline characterisation and tailoring towards the study sample may be beneficial for achieving targeted lifestyle interventions.

sted, utgiver, år, opplag, sider
Elsevier, 2023
Emneord
Magnetic resonance imaging (MRI), Modifiable lifestyle factors, Old age, White matter hyperintensities
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-214977 (URN)10.1016/j.neurobiolaging.2023.07.023 (DOI)37619515 (PubMedID)2-s2.0-85172425623 (Scopus ID)
Forskningsfinansiär
Novo Nordisk Foundation, NNF20OC0064869EU, Horizon 2020, 732592
Tilgjengelig fra: 2023-10-16 Laget: 2023-10-16 Sist oppdatert: 2023-10-16bibliografisk kontrollert
Ryberg, M., Boraxbekk, C.-J., Kjaer, M. & Demnitz, N. (2023). Effects of acute physical activity on brain metabolites as measured by magnetic resonance spectroscopy (1H-MRS) in humans: a systematic review. Heliyon, 9(10), Article ID e20534.
Åpne denne publikasjonen i ny fane eller vindu >>Effects of acute physical activity on brain metabolites as measured by magnetic resonance spectroscopy (1H-MRS) in humans: a systematic review
2023 (engelsk)Inngår i: Heliyon, E-ISSN 2405-8440, Vol. 9, nr 10, artikkel-id e20534Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Physical activity (PA) promotes brain health in a variety of domains including cognition, mood, and neuroplasticity. At the neurochemical level, the mechanisms underlying these effects in the brain are not fully understood. With proton Magnetic Resonance Spectroscopy (1H-MRS), it is possible to non-invasively quantify metabolite concentrations, enabling studies to obtain measures of exercise-induced neurochemical changes. This systematic review aimed to examine the existing literature on acute effects of PA on brain metabolites as measured by 1H-MRS. Four databases (Cochrane Central Register of Controlled Trials, PubMed, Embase, and PsycINFO) were searched, identifying 2965 studies, of which 9 met the inclusion criteria. Across studies, Gamma-AminoButyric Acid (GABA) and lactate tended to increase after exercise, while no significant changes in choline were reported. For glutamine/glutamate (Glx), studies were inconclusive. Conclusions were limited by the lack of consensus on 1H-MRS data processing and exercise protocols. To reduce inter-study differences, future studies are recommended to: (1) apply a standardized exercise index, (2) consider the onset time of MRS scans, and (3) follow standardized MRS quantification methods.

sted, utgiver, år, opplag, sider
Elsevier, 2023
Emneord
Spectroscopy, Exercise, Neurochemistry, Interventions
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-218224 (URN)10.1016/j.heliyon.2023.e20534 (DOI)001088294100001 ()37818016 (PubMedID)2-s2.0-85173660640 (Scopus ID)
Tilgjengelig fra: 2023-12-18 Laget: 2023-12-18 Sist oppdatert: 2023-12-18bibliografisk kontrollert
Simonsson, E., Levik Sandström, S., Hedlund, M., Holmberg, H., Johansson, B., Lindelöf, N., . . . Rosendahl, E. (2023). Effects of controlled supramaximal high-intensity interval training on cardiorespiratory fitness and global cognitive function in older adults: the Umeå hit study-a randomized controlled trial. The journals of gerontology. Series A, Biological sciences and medical sciences, 78(9), 1581-1590
Åpne denne publikasjonen i ny fane eller vindu >>Effects of controlled supramaximal high-intensity interval training on cardiorespiratory fitness and global cognitive function in older adults: the Umeå hit study-a randomized controlled trial
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2023 (engelsk)Inngår i: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 78, nr 9, s. 1581-1590Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: This study examined the effects of regulated and controlled supramaximal high-intensity interval training (HIT) adapted for older adults, compared to moderate-intensity training (MIT), on cardiorespiratory fitness; cognitive, cardiovascular, and muscular function; and quality of life.

METHODS: Sixty-eight nonexercising older adults (66-79 years, 44% males) were randomized to 3 months of twice-weekly HIT (20-minute session including 10 × 6-second intervals) or MIT (40-minute session including 3 × 8-minute intervals) on stationary bicycles in an ordinary gym setting. Individualized target intensity was watt controlled with a standardized pedaling cadence and individual adjustment of the resistance load. Primary outcomes were cardiorespiratory fitness (V̇o2peak) and global cognitive function (unit-weighted composite).

RESULTS: V̇o2peak increased significantly (mean 1.38 mL/kg/min, 95% CI [0.77, 1.98]), with no between-group difference (mean difference 0.05 [-1.17, 1.25]). Global cognition did not improve (0.02 [-0.05, 0.09]), nor differed between groups (0.11 [-0.03, 0.24]). Significant between-group differences in change were observed for working memory (0.32 [0.01, 0.64]), and maximal isometric knee extensor muscle strength (0.07 N·m/kg [0.003, 0.137]), both in favor of HIT. Irrespective of the group, there was a negative change in episodic memory (-0.15 [-0.28, -0.02]), a positive change in visuospatial ability (0.26 [0.08, 0.44]), and a decrease in systolic (-2.09 mmHg [-3.54, -0.64]) and diastolic (-1.27 mmHg [-2.31, -0.25]) blood pressure.

CONCLUSIONS: In nonexercising older adults, 3 months of watt-controlled supramaximal HIT improved cardiorespiratory fitness and cardiovascular function to a similar extent as MIT, despite half the training time. In favor of HIT, there was an improvement in muscular function and a potential domain-specific effect on working memory.

CLINICAL TRIAL REGISTRATION: NCT03765385.

sted, utgiver, år, opplag, sider
Oxford University Press, 2023
Emneord
Aerobic capacity, HIIT, Moderate-intensity training, SIT, Sprint interval training
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-214207 (URN)10.1093/gerona/glad070 (DOI)000959356800001 ()36972981 (PubMedID)2-s2.0-85169177109 (Scopus ID)
Forskningsfinansiär
Swedish Research Council, 2017-00912Forte, Swedish Research Council for Health, Working Life and Welfare, 2020-00159The Kamprad Family FoundationThe Dementia Association - The National Association for the Rights of the DementedFoundation for the Memory of Ragnhild and Einar LundströmThe Kempe FoundationsUmeå University
Tilgjengelig fra: 2023-09-08 Laget: 2023-09-08 Sist oppdatert: 2024-07-02bibliografisk kontrollert
Stiernman, L., Dubol, M., Comasco, E., Sundström-Poromaa, I., Boraxbekk, C.-J., Johansson, I.-M. & Bixo, M. (2023). Emotion-induced brain activation across the menstrual cycle in individuals with premenstrual dysphoric disorder and associations to serum levels of progesterone-derived neurosteroids. Translational Psychiatry, 13(1), Article ID 124.
Åpne denne publikasjonen i ny fane eller vindu >>Emotion-induced brain activation across the menstrual cycle in individuals with premenstrual dysphoric disorder and associations to serum levels of progesterone-derived neurosteroids
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2023 (engelsk)Inngår i: Translational Psychiatry, E-ISSN 2158-3188, Vol. 13, nr 1, artikkel-id 124Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Premenstrual dysphoric disorder (PMDD) is a debilitating disorder characterized by severe mood symptoms in the luteal phase of the menstrual cycle. PMDD symptoms are hypothesized to be linked to an altered sensitivity to normal luteal phase levels of allopregnanolone (ALLO), a GABAA-modulating progesterone metabolite. Moreover, the endogenous 3β-epimer of ALLO, isoallopregnanolone (ISO), has been shown to alleviate PMDD symptoms through its selective and dose-dependent antagonism of the ALLO effect. There is preliminary evidence showing altered recruitment of brain regions during emotion processing in PMDD, but whether this is associated to serum levels of ALLO, ISO or their relative concentration is unknown. In the present study, subjects with PMDD and asymptomatic controls underwent functional magnetic resonance imaging (fMRI) in the mid-follicular and the late-luteal phase of the menstrual cycle. Brain responses to emotional stimuli were investigated and related to serum levels of ovarian steroids, the neurosteroids ALLO, ISO, and their ratio ISO/ALLO. Participants with PMDD exhibited greater activity in brain regions which are part of emotion-processing networks during the late-luteal phase of the menstrual cycle. Furthermore, activity in key regions of emotion processing networks - the parahippocampal gyrus and amygdala - was differentially associated to the ratio of ISO/ALLO levels in PMDD subjects and controls. Specifically, a positive relationship between ISO/ALLO levels and brain activity was found in PMDD subjects, while the opposite was observed in controls. In conclusion, individuals with PMDD show altered emotion-induced brain responses in the late-luteal phase of the menstrual cycle which may be related to an abnormal response to physiological levels of GABAA-active neurosteroids.

sted, utgiver, år, opplag, sider
Springer Nature, 2023
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-206958 (URN)10.1038/s41398-023-02424-3 (DOI)000968319200001 ()37055419 (PubMedID)2-s2.0-85152386545 (Scopus ID)
Tilgjengelig fra: 2023-04-26 Laget: 2023-04-26 Sist oppdatert: 2024-05-17bibliografisk kontrollert
Nyberg, L., Andersson, M., Lundquist, A., Baaré, W. F. .., Bartrés-Faz, D., Bertram, L., . . . Walhovd, K. B. (2023). Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates. Cerebral Cortex, 33(9), 5075-5081
Åpne denne publikasjonen i ny fane eller vindu >>Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates
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2023 (engelsk)Inngår i: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 33, nr 9, s. 5075-5081Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

sted, utgiver, år, opplag, sider
Oxford University Press, 2023
Emneord
aging, individual differences, caudate, hippocampus, cortex
HSV kategori
Forskningsprogram
medicin
Identifikatorer
urn:nbn:se:umu:diva-201287 (URN)10.1093/cercor/bhac400 (DOI)000863898100001 ()36197324 (PubMedID)2-s2.0-85159256770 (Scopus ID)
Forskningsfinansiär
Knut and Alice Wallenberg FoundationEU, Horizon 2020, 732592
Tilgjengelig fra: 2022-11-27 Laget: 2022-11-27 Sist oppdatert: 2023-06-07bibliografisk kontrollert
Demnitz, N., Gates, A. T., Mortensen, E. L., Garde, E., Wimmelmann, C. L., Siebner, H. R., . . . Boraxbekk, C.-J. (2023). Is it all in the baseline? Trajectories of chair stand performance over 4 years and their association with grey matter structure in older adults. Human Brain Mapping, 44(11), 4299-4309
Åpne denne publikasjonen i ny fane eller vindu >>Is it all in the baseline? Trajectories of chair stand performance over 4 years and their association with grey matter structure in older adults
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2023 (engelsk)Inngår i: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 44, nr 11, s. 4299-4309Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Understanding individual variability in response to physical activity is key to developing more effective and personalised interventions for healthy ageing. Here, we aimed to unpack individual differences by using longitudinal data from a randomised-controlled trial of a 12-month muscle strengthening intervention in older adults. Physical function of the lower extremities was collected from 247 participants (66.3 ± 2.5 years) at four time-points. At baseline and at year 4, participants underwent 3 T MRI brain scans. K-means longitudinal clustering was used to identify patterns of change in chair stand performance over 4 years, and voxel-based morphometry was applied to map structural grey matter volume at baseline and year 4. Results identified three groups showing trajectories of poor (33.6%), mid (40.1%), and high (26.3%) performance. Baseline physical function, sex, and depressive symptoms significantly differed between trajectory groups. High performers showed greater grey matter volume in the motor cerebellum compared to the poor performers. After accounting for baseline chair stand performance, participants were re-assigned to one of four trajectory-based groups: moderate improvers (38.9%), maintainers (38.5%), improvers (13%), and decliners (9.7%). Clusters of significant grey matter differences were observed between improvers and decliners in the right supplementary motor area. Trajectory-based group assignments were unrelated to the intervention arms of the study. In conclusion, patterns of change in chair stand performance were associated with greater grey matter volumes in cerebellar and cortical motor regions. Our findings emphasise that how you start matters, as baseline chair stand performance was associated with cerebellar volume 4 years later.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2023
Emneord
ageing, longitudinal analysis, physical activity, physical function, VBM
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-209197 (URN)10.1002/hbm.26346 (DOI)000991689100001 ()37219945 (PubMedID)2-s2.0-85159866920 (Scopus ID)
Tilgjengelig fra: 2023-06-09 Laget: 2023-06-09 Sist oppdatert: 2023-11-06bibliografisk kontrollert
Fjell, A. M., Sørensen, Ø., Wang, Y., Amlien, I. K., Baaré, W. F., Bartrés-Faz, D., . . . Walhovd, K. B. (2023). Is short sleep bad for the brain?: Brain structure and cognitive function in short sleepers. Journal of Neuroscience, 43(28), 5241-5250
Åpne denne publikasjonen i ny fane eller vindu >>Is short sleep bad for the brain?: Brain structure and cognitive function in short sleepers
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2023 (engelsk)Inngår i: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 43, nr 28, s. 5241-5250Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Many sleep less than recommended without experiencing daytime sleepiness. According to prevailing views, short sleep increases risk of lower brain health and cognitive function. Chronic mild sleep deprivation could cause undetected sleep debt, negatively affecting cognitive function and brain health. However, it is possible that some have less sleep need and are more resistant to negative effects of sleep loss. We investigated this using a cross-sectional and longitudinal sample of 47,029 participants of both sexes (20-89 years) from the Lifebrain consortium, Human Connectome project (HCP) and UK Biobank (UKB), with measures of self-reported sleep, including 51,295 MRIs of the brain and cognitive tests. A total of 740 participants who reported to sleep <6 h did not experience daytime sleepiness or sleep problems/disturbances interfering with falling or staying asleep. These short sleepers showed significantly larger regional brain volumes than both short sleepers with daytime sleepiness and sleep problems (n = 1742) and participants sleeping the recommended 7-8 h (n = 3886). However, both groups of short sleepers showed slightly lower general cognitive function (GCA), 0.16 and 0.19 SDs, respectively. Analyses using accelerometer-estimated sleep duration confirmed the findings, and the associations remained after controlling for body mass index, depression symptoms, income, and education. The results suggest that some people can cope with less sleep without obvious negative associations with brain morphometry and that sleepiness and sleep problems may be more related to brain structural differences than duration. However, the slightly lower performance on tests of general cognitive abilities warrants closer examination in natural settings.

SIGNIFICANCE STATEMENT: Short habitual sleep is prevalent, with unknown consequences for brain health and cognitive performance. Here, we show that daytime sleepiness and sleep problems are more strongly related to regional brain volumes than sleep duration. However, participants sleeping ≤6 h had slightly lower scores on tests of general cognitive function (GCA). This indicates that sleep need is individual and that sleep duration per se is very weakly if at all related brain health, while daytime sleepiness and sleep problems may show somewhat stronger associations. The association between habitual short sleep and lower scores on tests of general cognitive abilities must be further scrutinized in natural settings.

Emneord
brain, cognition, hippocampus, MRI, sleep, sleepiness
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-212215 (URN)10.1523/JNEUROSCI.2330-22.2023 (DOI)37365003 (PubMedID)2-s2.0-85164626158 (Scopus ID)
Forskningsfinansiär
EU, Horizon 2020, 732592EU, European Research Council, 283634EU, European Research Council, 725025EU, European Research Council, 313440The Research Council of NorwayKnut and Alice Wallenberg FoundationEU, European Research Council, 677804Wellcome trust, 203139/Z/16/ZNIH (National Institutes of Health)
Tilgjengelig fra: 2023-07-21 Laget: 2023-07-21 Sist oppdatert: 2024-03-20bibliografisk kontrollert
Prosjekter
Fysisk aktivitets påverkan på hjärnan (dopaminsystemet), kognition och åldrande [2012-00530_VR]; Umeå universitet
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0002-4458-6475