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Hrubá, F., Černá, M., Chen, C., Harari, F., Horvat, M., Koppová, K., . . . Bergdahl, I. (2023). A regional comparison of children's blood cadmium, lead, and mercury in rural, urban and industrial areas of six European countries, and China, Ecuador, and Morocco. International Journal of Occupational Medicine and Environmental Health, 36(3), 349-364
Åpne denne publikasjonen i ny fane eller vindu >>A regional comparison of children's blood cadmium, lead, and mercury in rural, urban and industrial areas of six European countries, and China, Ecuador, and Morocco
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2023 (engelsk)Inngår i: International Journal of Occupational Medicine and Environmental Health, ISSN 1232-1087, E-ISSN 1896-494X, Vol. 36, nr 3, s. 349-364Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

OBJECTIVES: The authors aimed to evaluate whether blood cadmium (B-Cd), lead (B-Pb) and mercury (B-Hg) in children differ regionally in 9 countries, and to identify factors correlating with exposure.

MATERIAL AND METHODS: The authors performed a cross-sectional study of children aged 7-14 years, living in 2007-2008 in urban, rural, or potentially polluted ("hot spot") areas (ca. 50 children from each area, in total 1363 children) in 6 European and 3 non-European countries. The authors analyzed Cd, Pb, and total Hg in blood and collected information on potential determinants of exposure through questionnaires. Regional differences in exposure levels were assessed within each country.

RESULTS: Children living near industrial "hot-spots" had B-Cd 1.6 (95% CI: 1.4-1.9) times higher in the Czech Republic and 2.1 (95% CI:1.6-2.8) times higher in Poland, as compared to urban children in the same countries (geometric means [GM]: 0.13 μg/l and 0.15 μg/l, respectively). Correspondingly, B-Pb in the "hot spot" areas was 1.8 (95% CI: 1.6-2.1) times higher than in urban areas in Slovakia and 2.3 (95% CI: 1.9-2.7) times higher in Poland (urban GM: 19.4 μg/l and 16.3 μg/l, respectively). In China and Morocco, rural children had significantly lower B-Pb than urban ones (urban GM: 64 μg/l and 71 μg/l, respectively), suggesting urban exposure from leaded petrol, water pipes and/or coal-burning. Hg "hot spot" areas in China had B-Hg 3.1 (95% CI: 2.7-3.5) times higher, and Ecuador 1.5 (95% CI: 1.2-1.9) times higher, as compared to urban areas (urban GM: 2.45 μg/l and 3.23 μg/l, respectively). Besides industrial exposure, traffic correlated with B-Cd; male sex, environmental tobacco smoke, and offal consumption with B-Pb; and fish consumption and amalgam fillings with B-Hg. However, these correlations could only marginally explain regional differences.

CONCLUSIONS: These mainly European results indicate that some children experience about doubled exposures to toxic elements just because of where they live. These exposures are unsafe, identifiable, and preventable and therefore call for preventive actions.

sted, utgiver, år, opplag, sider
Poland: Nofer Institute of Occupational Medicine, 2023
Emneord
biological monitoring, cadmium, child, environmental pollutants, lead, mercury
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-214412 (URN)10.13075/ijomeh.1896.02139 (DOI)37681424 (PubMedID)2-s2.0-85170188858 (Scopus ID)
Tilgjengelig fra: 2023-09-18 Laget: 2023-09-18 Sist oppdatert: 2023-09-18bibliografisk kontrollert
Hansén, N., Ljungberg, J., Bergdahl, I., Hultdin, J., Näslund, U., Johansson, B. & Söderberg, S. (2023). Adipokines are possible risk markers for aortic stenosis requiring surgery. Scandinavian Cardiovascular Journal, 57(1), Article ID 2247193.
Åpne denne publikasjonen i ny fane eller vindu >>Adipokines are possible risk markers for aortic stenosis requiring surgery
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2023 (engelsk)Inngår i: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 57, nr 1, artikkel-id 2247193Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objectives: Aortic stenosis (AS) is the most prevalent valvular heart disease among adults. The adipocyte-derived hormones, leptin and adiponectin, have profound metabolic actions. We examined whether these adipokines are independently associated with future aortic valve replacement (AVR).

Design: In this longitudinal case-control study, we identified 336 cases who had undergone AVR due to AS, and who had previously participated in population-based health surveys. Two referents were matched to each case and leptin and adiponectin concentrations were analysed from stored baseline survey samples. Uni- and multivariable logistic regression analyses were used to estimate the risk of future AVR. An additional cohort was identified for validation including 106 cases with AVR and 212 matched referents.

Results: Median age (interquartile range (IQR)) in years at survey was 59.9 (10.4) and at surgery 68.3 (12.7), and 48% were women. An elevated concentration of leptin was not associated with future AVR (odds ratio [95% confidence interval]) (1.10 [0.92–1.32]), although leptin was associated with a higher risk in patients with coronary artery disease (CAD) having more than 5 years between survey and AVR (1.41 [1.08–1.84]). Adiponectin was not associated with higher risk for future AVR (0.95 [0.82–1.11]), although after stratification for age, higher levels were associated with reduced risk for AVR in persons aged ≥60 years at surgery (0.79 [0.64–0.98]). In the validation study, leptin was associated with future AVR whereas adiponectin was not. None of the associations remained significant after adjustment for body mass index (BMI).

Conclusions: The adipokine leptin may promote the development of AS.

sted, utgiver, år, opplag, sider
Taylor & Francis, 2023
Emneord
adiponectin, Aortic stenosis, fat mass, leptin, prospective study, risk markers
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-214075 (URN)10.1080/14017431.2023.2247193 (DOI)001050266400001 ()37592808 (PubMedID)2-s2.0-85168287214 (Scopus ID)
Forskningsfinansiär
Swedish Heart Lung Foundation, 20100635Swedish Heart Lung Foundation, 20120631Swedish Heart Lung Foundation, 20140799Swedish Heart Lung Foundation, 20130630Region Västerbotten, RV-967561Umeå University, 964731
Tilgjengelig fra: 2023-09-04 Laget: 2023-09-04 Sist oppdatert: 2023-09-04bibliografisk kontrollert
Schillemans, T., Bergdahl, I., Hanhineva, K., Shi, L., Donat-Vargas, C., Koponen, J., . . . Brunius, C. (2023). Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations. Environmental Research, 216, Article ID 114570.
Åpne denne publikasjonen i ny fane eller vindu >>Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations
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2023 (engelsk)Inngår i: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 216, artikkel-id 114570Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The wide-spread environmental pollutants per- and polyfluoroalkyl substances (PFAS) have repeatedly been associated with elevated serum cholesterol in humans. However, underlying mechanisms are still unclear. Furthermore, we have previously observed inverse associations with plasma triglycerides. To better understand PFAS-induced effects on lipid pathways we investigated associations of PFAS-related metabolite features with plasma cholesterol and triglyceride concentrations. We used 290 PFAS-related metabolite features that we previously discovered from untargeted liquid chromatography-mass spectometry metabolomics in a case-control study within the Swedish Västerbotten Intervention Programme cohort. Herein, we studied associations of these PFAS-related metabolite features with plasma cholesterol and triglyceride concentrations in plasma samples from 187 healthy control subjects collected on two occasions between 1991 and 2013. The PFAS-related features did not associate with cholesterol, but 50 features were associated with triglycerides. Principal component analysis on these features indicated that one metabolite pattern, dominated by glycerophospholipids, correlated with longer chain PFAS and associated inversely with triglycerides (both cross-sectionally and prospectively), after adjustment for confounders. The observed time-trend of the metabolite pattern resembled that of the longer chain PFAS, with higher levels during the years 2004-2010. Mechanisms linking PFAS exposures to triglycerides may thus occur via longer chain PFAS affecting glycerophospholipid metabolism. If the results reflect a cause-effect association, as implied by the time-trend and prospective analyses, this may affect the general adult population.

sted, utgiver, år, opplag, sider
Elsevier, 2023
Emneord
Cholesterol, HBM4EU, Metabolomics, Per- and polyfluoroalkyl substances, Triglycerides
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-200731 (URN)10.1016/j.envres.2022.114570 (DOI)000901257900002 ()36243049 (PubMedID)2-s2.0-85139821796 (Scopus ID)
Forskningsfinansiär
Swedish Research Council, 2018-05973Swedish Research Council, 2017-00650Swedish Research Council, 2017-00822Swedish Research Council, 2017-05840Swedish Research Council Formas, 2016-00314Swedish Research Council Formas, 2020-01653Forte, Swedish Research Council for Health, Working Life and Welfare, 2012-0758Dr P Håkanssons stiftelseEU, Horizon 2020, 733032
Tilgjengelig fra: 2022-11-03 Laget: 2022-11-03 Sist oppdatert: 2023-09-05bibliografisk kontrollert
Bergdahl, I. (2023). Correspondence on "Endocytosis-Mediated Transport of Pb in Rat Blood Cells" [Letter to the editor]. Environmental Science and Technology, 57(40), 15134-15135
Åpne denne publikasjonen i ny fane eller vindu >>Correspondence on "Endocytosis-Mediated Transport of Pb in Rat Blood Cells"
2023 (engelsk)Inngår i: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 57, nr 40, s. 15134-15135Artikkel i tidsskrift, Letter (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
American Chemical Society (ACS), 2023
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-216139 (URN)10.1021/acs.est.3c06212 (DOI)37769196 (PubMedID)2-s2.0-85174859461 (Scopus ID)
Merknad

Comment on:

Guo,H.; Tang,Y.; Li,Y.; Tian,H.; Zhang,T.; Li,Y.; Liu,L.; He,B.; Hu,L.; Jiang,G. Endocytosis-mediated transport of Pb in rat blood cells. Environ. Sci. Technol. 2023, 57, 8514-8523. DOI: 10.1021/acs.est.3c02182

Tilgjengelig fra: 2023-11-02 Laget: 2023-11-02 Sist oppdatert: 2023-11-02bibliografisk kontrollert
Sdougkou, K., Xie, H., Papazian, S., Bonnefille, B., Bergdahl, I. & Martin, J. W. (2023). Phospholipid removal for enhanced chemical exposomics in human plasma. Environmental Science and Technology, 57(28), 10173-10184
Åpne denne publikasjonen i ny fane eller vindu >>Phospholipid removal for enhanced chemical exposomics in human plasma
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2023 (engelsk)Inngår i: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 57, nr 28, s. 10173-10184Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The challenge of chemical exposomics in human plasma is the 1000-fold concentration gap between endogenous substances and environmental pollutants. Phospholipids are the major endogenous small molecules in plasma, thus we validated a chemical exposomics protocol with an optimized phospholipid-removal step prior to targeted and non-targeted liquid chromatography high-resolution mass spectrometry. Increased injection volume with negligible matrix effect permitted sensitive multiclass targeted analysis of 77 priority analytes; median MLOQ = 0.05 ng/mL for 200 μL plasma. In non-targeted acquisition, mean total signal intensities of non-phospholipids were enhanced 6-fold in positive (max 28-fold) and 4-fold in negative mode (max 58-fold) compared to a control method without phospholipid removal. Moreover, 109 and 28% more non-phospholipid molecular features were detected by exposomics in positive and negative mode, respectively, allowing new substances to be annotated that were non-detectable without phospholipid removal. In individual adult plasma (100 μL, n = 34), 28 analytes were detected and quantified among 10 chemical classes, and quantitation of per- and polyfluoroalkyl substances (PFAS) was externally validated by independent targeted analysis. Retrospective discovery and semi-quantification of PFAS-precursors was demonstrated, and widespread fenuron exposure is reported in plasma for the first time. The new exposomics method is complementary to metabolomics protocols, relies on open science resources, and can be scaled to support large studies of the exposome.

sted, utgiver, år, opplag, sider
American Chemical Society (ACS), 2023
Emneord
chemical exposome, high-resolution mass spectrometry, liquid chromatography, multiclass targeted, non-targeted, phospholipid, plasma
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-212322 (URN)10.1021/acs.est.3c00663 (DOI)001021461300001 ()37394749 (PubMedID)2-s2.0-85164670955 (Scopus ID)
Forskningsfinansiär
Swedish Research Council, 2018-03409Swedish Research Council, 2017-00650
Tilgjengelig fra: 2023-07-25 Laget: 2023-07-25 Sist oppdatert: 2023-07-25bibliografisk kontrollert
Charles, D., Berg, V., Nøst, T. H., Wilsgaard, T., Bergdahl, I., Huber, S., . . . Rylander, C. (2023). Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosis. International journal of hygiene and environmental health (Print), 249, Article ID 114148.
Åpne denne publikasjonen i ny fane eller vindu >>Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosis
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2023 (engelsk)Inngår i: International journal of hygiene and environmental health (Print), ISSN 1438-4639, E-ISSN 1618-131X, Vol. 249, artikkel-id 114148Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Previous studies have reported associations between certain persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM). Polybrominated diphenyl ethers (PBDEs) are a class of POPs that are found in increasing concentrations in humans. Although obesity is a known risk factor for T2DM and PBDEs are fat-soluble, very few studies have investigated associations between PBDEs and T2DM. No longitudinal studies have assessed associations between repeated measurements of PBDE and T2DM in the same individuals and compared time trends of PBDEs in T2DM cases and controls.

Objectives: To investigate associations between pre- and post-diagnostic measurements of PBDEs and T2DM and to compare time trends of PBDEs in T2DM cases and controls.

Methods: Questionnaire data and serum samples from participants in the Tromsø Study were used to conduct a longitudinal nested case-control study among 116 T2DM cases and 139 controls. All included study participants had three pre-diagnostic blood samples (collected before T2DM diagnosis in cases), and up to two post-diagnostic samples after T2DM diagnosis. We used logistic regression models to investigate pre- and post-diagnostic associations between PBDEs and T2DM, and linear mixed-effect models to assess time trends of PBDEs in T2DM cases and controls.

Results: We observed no substantial pre- or post-diagnostic associations between any of the PBDEs and T2DM, except for BDE-154 at one of the post-diagnostic time-points (OR = 1.65, 95% CI: 1.00, 2.71). The overall time trends of PBDE concentrations were similar for cases and controls.

Discussion: The study did not support PBDEs increasing the odds of T2DM, prior to or after T2DM diagnosis. T2DM status did not influence the time trends of PBDE concentrations.

sted, utgiver, år, opplag, sider
Elsevier, 2023
Emneord
Polybrominated diphenyl ethers, Pre- and post-diagnostic associations, Repeated measurements, Time trends, Type 2 diabetes mellitus
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-205784 (URN)10.1016/j.ijheh.2023.114148 (DOI)000955903500001 ()36881976 (PubMedID)2-s2.0-85149801578 (Scopus ID)
Tilgjengelig fra: 2023-03-28 Laget: 2023-03-28 Sist oppdatert: 2023-09-05bibliografisk kontrollert
Bergdahl, I. & Skerfving, S. (2022). Lead (5ed.). In: Gunnar F. Nordberg; Max Costa (Ed.), Handbook on the toxicology of metals: volume II: Specific metals (pp. 427-493). Elsevier
Åpne denne publikasjonen i ny fane eller vindu >>Lead
2022 (engelsk)Inngår i: Handbook on the toxicology of metals: volume II: Specific metals / [ed] Gunnar F. Nordberg; Max Costa, Elsevier, 2022, 5, s. 427-493Kapittel i bok, del av antologi (Fagfellevurdert)
Abstract [en]

Inorganic lead is the most extensively studied environmental toxin. Today's humans have in the order of 100 times higher lead exposure, compared to prehistoric humans, mainly from food. The exposure was even higher during the 20th century, mainly due to lead addition to gasoline. Today, high exposures occur in many occupations, but also through, for example, contaminated drinking water, traditional drugs, lead paint, and soil and dust in "hotspots" around mines and smelters. Absorbed lead is widely distributed in the body. It accumulates in the skeleton, which, in turn, causes endogenous exposure, especially during pregnancy/lactation and in osteoporosis. Lead passes over the placenta into the fetus, and via breast milk into the infant. The mode(s) of action is not known; different mechanisms might be operating at different concentrations. Toxic effects occur first in the nervous system of fetuses/infants/children, with small cognitive effects already at a mean blood lead concentration (B-Pb) of ≤0.05. μmol/L (≤10. μg/L; which is well below the worldwide mean), without any threshold. Lead effects have also been reported for the cardiovascular system [increase of blood pressure at B-Pb well below 0.5. μmol/L (100. μg/L)], the kidney, post- and prenatal growth, cognition in also adults and elderly, the blood, the immune system, the gastrointestinal tract, and the female and male reproduction. There is important genetic modification of the toxicity. Lead is carcinogenic in animal experiments, but there is only limited evidence in humans.

The organolead compounds tetraethyl- and tetramethyllead, earlier used in enormous quantities in leaded gasoline, are easily absorbed at inhalation and through the skin and may cause acute encephalopathia.

sted, utgiver, år, opplag, sider
Elsevier, 2022 Opplag: 5
Emneord
Blood pressure, Cardiovascular, CNS, Environment, Epidemiology, Fetus, IQ, Lead, Nervous system, Occupational, Public health, Toxicity
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-193328 (URN)10.1016/B978-0-12-822946-0.00036-2 (DOI)2-s2.0-85126280419 (Scopus ID)9780128229460 (ISBN)
Tilgjengelig fra: 2022-03-29 Laget: 2022-03-29 Sist oppdatert: 2022-03-29bibliografisk kontrollert
Wen, Q., Verheijen, M., Wittens, M. M., Czuryło, J., Engelborghs, S., Hauser, D., . . . Krauskopf, J. (2022). Lead-exposure associated miRNAs in humans and Alzheimer’s disease as potential biomarkers of the disease and disease processes. Scientific Reports, 12(1), Article ID 15966.
Åpne denne publikasjonen i ny fane eller vindu >>Lead-exposure associated miRNAs in humans and Alzheimer’s disease as potential biomarkers of the disease and disease processes
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2022 (engelsk)Inngår i: Scientific Reports, E-ISSN 2045-2322, Vol. 12, nr 1, artikkel-id 15966Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Alzheimer’s disease (AD) is a neurodegenerative disease that eventually affects memory and behavior. The identification of biomarkers based on risk factors for AD provides insight into the disease since the exact cause of AD remains unknown. Several studies have proposed microRNAs (miRNAs) in blood as potential biomarkers for AD. Exposure to heavy metals is a potential risk factor for onset and development of AD. Blood cells of subjects that are exposed to lead detected in the circulatory system, potentially reflect molecular responses to this exposure that are similar to the response of neurons. In this study we analyzed blood cell-derived miRNAs derived from a general population as proxies of potentially AD-related mechanisms triggered by lead exposure. Subsequently, we analyzed these mechanisms in the brain tissue of AD subjects and controls. A total of four miRNAs were identified as lead exposure-associated with hsa-miR-3651, hsa-miR-150-5p and hsa-miR-664b-3p being negatively and hsa-miR-627 positively associated. In human brain derived from AD and AD control subjects all four miRNAs were detected. Moreover, two miRNAs (miR-3651, miR-664b-3p) showed significant differential expression in AD brains versus controls, in accordance with the change direction of lead exposure. The miRNAs’ gene targets were validated for expression in the human brain and were found enriched in AD-relevant pathways such as axon guidance. Moreover, we identified several AD relevant transcription factors such as CREB1 associated with the identified miRNAs. These findings suggest that the identified miRNAs are involved in the development of AD and might be useful in the development of new, less invasive biomarkers for monitoring of novel therapies or of processes involved in AD development.

sted, utgiver, år, opplag, sider
Nature Publishing Group, 2022
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-200102 (URN)10.1038/s41598-022-20305-5 (DOI)36153426 (PubMedID)2-s2.0-85138460597 (Scopus ID)
Tilgjengelig fra: 2022-10-12 Laget: 2022-10-12 Sist oppdatert: 2022-10-12bibliografisk kontrollert
Charles, D., Berg, V., Nøst, T. H., Bergdahl, I., Huber, S., Ayotte, P., . . . Rylander, C. (2022). Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus. Environmental Research, 204, Article ID 112129.
Åpne denne publikasjonen i ny fane eller vindu >>Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus
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2022 (engelsk)Inngår i: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 204, artikkel-id 112129Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Positive associations have been reported between persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM); however, causality has not been established. Over the last decades, environmental exposure to legacy POPs has decreased, complicating epidemiological studies. In addition, physiological risk factors for T2DM may also influence POP concentrations, contributing to a complex network of factors that could impact associations with T2DM. Longitudinal studies on this topic are lacking, and few have assessed prospective and cross-sectional associations between repeated POP measurements and T2DM in the same individuals, which may shed light on causality.

Objectives: To compare longitudinal trends in concentrations of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in T2DM cases and controls, and to examine prospective and cross-sectional associations between PCBs, OCPs and T2DM at different time-points before and after T2DM diagnosis in cases.

Methods: We conducted a longitudinal, nested case-control study (1986–2016) of 116 T2DM cases and 139 controls from the Tromsø Study. All participants had three blood samples collected before T2DM diagnosis in cases, and up to two samples thereafter. We used linear mixed-effect models to assess temporal changes of POPs within and between T2DM cases and controls, and logistic regression models to investigate the associations between different POPs and T2DM at different time-points.

Results: PCBs, trans-nonachlor, cis-nonachlor, oxychlordane, cis-heptachlor epoxide, p,p’-DDE, and p,p’-DDT declined more slowly in cases than controls, whereas β-HCH and HCB declined similarly in both groups. Most POPs showed positive associations between both pre- and post-diagnostic concentrations and T2DM, though effect estimates were imprecise. These associations were most consistent for cis-heptachlor epoxide.

Discussion: The observed positive associations between certain POPs and T2DM may be because of higher POP concentrations within prospective T2DM cases, due to slower temporal declines as compared to controls.

sted, utgiver, år, opplag, sider
Elsevier, 2022
Emneord
Longitudinal assessment, Persistent organic pollutants, Pre- and post-diagnostic associations, Repeated measurements, Type 2 diabetes mellitus
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-188388 (URN)10.1016/j.envres.2021.112129 (DOI)000704710900003 ()2-s2.0-85115969531 (Scopus ID)
Tilgjengelig fra: 2021-10-07 Laget: 2021-10-07 Sist oppdatert: 2023-09-05bibliografisk kontrollert
Porta, M., Gasull, M., Pumarega, J., Kiviranta, H., Rantakokko, P., Raaschou-Nielsen, O., . . . Vineis, P. (2022). Plasma concentrations of persistent organic pollutants and pancreatic cancer risk. International Journal of Epidemiology, 51(2), 479-490
Åpne denne publikasjonen i ny fane eller vindu >>Plasma concentrations of persistent organic pollutants and pancreatic cancer risk
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2022 (engelsk)Inngår i: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 51, nr 2, s. 479-490Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts.

Methods: We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline.

Results: Some associations were observed at higher concentrations of p, p'-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk.

Conclusions: Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.

sted, utgiver, år, opplag, sider
Oxford University Press, 2022
Emneord
biomarkers, environmental health, methods, Pancreatic cancer, persistent organic pollutants
HSV kategori
Forskningsprogram
kirurgi
Identifikatorer
urn:nbn:se:umu:diva-203107 (URN)10.1093/ije/dyab115 (DOI)000756415800001 ()34259837 (PubMedID)2-s2.0-85128496343 (Scopus ID)
Forskningsfinansiär
Swedish Research Council, 2017-00650
Tilgjengelig fra: 2023-01-16 Laget: 2023-01-16 Sist oppdatert: 2023-06-08bibliografisk kontrollert
Prosjekter
Könsskillnader i hur stroke och hjärtinfarkt relaterar till fiskkonsumtion, metylkvicksilver, fiskfetter och selen [2007-2024_Formas]; Umeå universitetVarför är diabetes typ 2 så starkt kopplat till koncentrationen av långlivade organiska miljöföroreningar i blodplasma? En fa... [2012-00758_Forte]; Umeå universitet
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0003-1227-6859