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Johansson, Magdalena
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Johansson, M., Johansson, L., Wennberg, M. & Lind, M. (2019). Alcohol Consumption and Risk of First-Time Venous Thromboembolism in Men and Women. Thrombosis and Haemostasis, 119(6), 962-970
Åpne denne publikasjonen i ny fane eller vindu >>Alcohol Consumption and Risk of First-Time Venous Thromboembolism in Men and Women
2019 (engelsk)Inngår i: Thrombosis and Haemostasis, ISSN 0340-6245, Vol. 119, nr 6, s. 962-970Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: The relationship between alcohol intake and risk of venous thromboembolism (VTE) is unclear. Men and women differ in their drinking habits, which may affect a possible association.

OBJECTIVE: This article investigates the association between alcohol consumption, alcohol dependence and VTE in the total population as well as in men and women separately.

METHODS: We performed a prospective, population-based cohort study in northern Sweden. Study participants were 108,025 (51% women) persons aged 30 to 60 years who underwent a health examination between 1985 and 2014. We assessed alcohol consumption and defined alcohol dependence using a questionnaire. The outcome was a validated first-time VTE.

RESULTS: The mean follow-up time was 13.9 years, and 2,054 participants had a first-time VTE. The mean alcohol consumption was 3.5 standard drinks weekly in men and 1.5 in women. Alcohol dependence was found in 10% of men and 3% of women. There was an association between alcohol consumption (hazard ratio [HR], 1.02; 95% confidence interval [CI], 1.00-1.03 per standard drink weekly) as well as alcohol dependence (HR, 1.27; 95% CI, 1.06-1.52) and VTE after adjustments. In men, the risk of VTE increased over quartiles of weekly alcohol consumption (p for trend 0.02), with a HR of 1.22 (95% CI, 1.01-1.47) for the highest quartile. Alcohol dependence was associated with VTE in men (HR, 1.30; 95% CI, 1.07-1.59). In women, there were no significant associations.

CONCLUSION: High alcohol consumption and alcohol dependence were associated with increased risk of first-time VTE in men, but not in women.

sted, utgiver, år, opplag, sider
Georg Thieme Verlag KG, 2019
Emneord
venous thromboembolism, venous thrombosis, alcohol consumption, alcohol intake, alcohol drinking, alcohol dependence, risk marker, prospective studies, cohort studies
HSV kategori
Forskningsprogram
medicin
Identifikatorer
urn:nbn:se:umu:diva-157495 (URN)10.1055/s-0039-1681100 (DOI)000474924300013 ()30900224 (PubMedID)2-s2.0-85066132287 (Scopus ID)
Prosjekter
Venous thromboEmbolism In Northern Sweden
Forskningsfinansiär
Swedish Research CouncilForte, Swedish Research Council for Health, Working Life and WelfareVästerbotten County Council
Tilgjengelig fra: 2019-03-24 Laget: 2019-03-24 Sist oppdatert: 2019-09-09bibliografisk kontrollert
Johansson, M. (2019). Epidemiology of venous thromboembolism with focus on risk markers. (Doctoral dissertation). Umeå: Umeå University
Åpne denne publikasjonen i ny fane eller vindu >>Epidemiology of venous thromboembolism with focus on risk markers
2019 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Alternativ tittel[sv]
Venös tromboembolism – epidemiologi med fokus på riskmarkörer
Abstract [en]

Background: Venous thromboembolism (VTE) is a vascular disease with an incidence of approximately 140 cases per 100,000 person-years in adults. The incidence of VTE has increased over the last decades, and more than 20% of affected individuals die in the first year after diagnosis. To reduce the incidence of VTE, it is important to identify modifiable risk factors for the condition.

Aims: The aims of this thesis were a) To study the incidence of first-time VTE and the prevalence of risk markers for VTE at the time of VTE diagnosis, b) To determine the validity of diagnoses of deep vein thrombosis and pulmonary embolism in administrative registries, and c) To study the association between glucose levels, diabetes, alcohol consumption, physical activity and risk of first-time VTE.

Methods: To determine the incidence of first-time VTE and the prevalence of risk markers for VTE at the time of VTE diagnosis, a retrospective, population-based cohort study was conducted. The study included all adult residents of Västerbotten County during the year 2006. All other aims were addressed in the prospective, population-based Venous thromboEmbolism In Northern Sweden (VEINS) cohort study. The VEINS cohort included 108,025 residents of Västerbotten County aged 30 to 60 years without previous VTE events. They were included from 1985 onwards and were followed until a VTE event, death, emigration, or the study end on September 5, 2014. All underwent a health examination within the Västerbotten Intervention Programme where weight, height, blood pressure and glucose levels were measured, and answered a questionnaire regarding smoking, education level, medication use, history of diabetes, alcohol intake and physical activity. VTE diagnoses were validated by review of medical records and radiology reports. To study the validity of diagnoses of deep vein thrombosis and pulmonary embolism in administrative registries, a registry search for International Classification of Diseases diagnosis codes indicating pulmonary embolism and/or deep vein thrombosis events was made in the Swedish National Patient Registry and the Cause of Death Registry. An additional search using an extended set of International Classification of Diseases diagnosis codes was performed in order to identify misclassified events.

Results: The incidence of first-time VTE was 137 (95% confidence interval [CI] 122–154) per 100,000 adults per year. The most common risk markers for VTE were recent hospitalization and concurrent malignancy. The positive predictive value for a diagnosis of pulmonary embolism was 80.7% (95% CI 78.4–82.9), and that of deep vein thrombosis 59.2% (95% CI 56.7–61.7). Misclassification occurred in 1.1% (95% CI 0.4–1.7) of pulmonary embolism events and in 16.4% (95% CI 14.2–18.7) of deep vein thrombosis events. In the VEINS cohort, a total of 2,054 participants experienced an objectively verified first-time VTE event during approximately 1.5 million person-years of follow-up. In univariable analysis, there were associations between fasting plasma glucose, oral glucose tolerance test two-hour post-load plasma glucose, diabetes and increased risk of first-time VTE. These associations were attenuated after adjustment for potential confounders, and were no longer significant. There was an association between alcohol consumption and risk of first-time VTE in men (for trend 0.02 after adjustments for increased risk of first-time VTE over quartiles of weekly alcohol consumption). Alcohol dependence was associated with risk of first-time VTE in men (hazard ratio [HR] 1.30; 95% CI 1.07–1.59 after adjustments). In women, there were no significant associations between alcohol consumption and risk of first-time VTE. Women who performed leisure time physical activity at least once a week had a lower risk of first-time VTE (HR 0.83; 95% CI 0.71–0.98 after adjustments) compared to women with less or no physical activity. Women with high occupational physical activity also had a lower risk of first-time VTE (HR 0.85; 95% CI 0.74–0.98 after adjustments). In men, there were no consistent association between either measure of physical activity and risk of first-time VTE. 

Conclusions: VTE is a common vascular disease. Registry data on diagnoses of pulmonary embolism, but not deep vein thrombosis, is of acceptable quality and can be considered for use in registry-based studies. Glucose levels and diabetes are not associated with risk of first-time VTE. Alcohol intake and alcohol dependence are associated with an increased risk of first-time VTE in men, whereas high leisure time physical activity and occupational physical activity are associated with a decreased risk of first-time VTE in women.

Abstract [sv]

Bakgrund: Venös trombos är en vanlig och allvarlig kärlsjukdom. De vanligaste formerna av venös trombos är djup ventrombos och lungemboli. Förekomsten av venös trombos har ökat under de senaste decennierna. Mer än en av fem personer som drabbas av venös trombos dör under det första året efter diagnos. Hos ungefär en tredjedel av dem som insjuknar i venös trombos hittar man ingen uppenbar förklaring till att de får sjukdomen. För att minska insjuknandet i venös trombos är det viktigt att identifiera påverkbara riskfaktorer för tillståndet.

Syfte: Syftet med denna avhandling var att studera frekvensen av nyinsjuknande i venös trombos i befolkningen och förekomsten av bidragande faktorer till venös trombos vid insjuknandet. Vi ville också undersöka i vilken utsträckning personer med en diagnoskod för venös trombos i sjukvårdsregister faktiskt haft en venös trombos. Slutligen ville vi studera om det finns ett samband mellan blodsockernivåer, diabetes, alkoholintag, fysisk aktivitet och risken för att senare i livet få en första venös trombos.

Metod: För att undersöka antalet personer som nyinsjuknar i venös trombos och förekomsten av riskmarkörer för venös trombos vid insjuknandet genomförde vi en retrospektiv (tillbakablickande) befolkningsbaserad studie. Vi registrerade alla vuxna i Västerbottens Län som fick venös trombos under år 2006 och vilka bidragande faktorer till venös trombos de hade vid insjuknandet. För att studera i vilken utsträckning diagnoser för venös trombos i sjukvårdsregister var korrekta gjorde vi en sökning för att hitta diagnoskoder för lungemboli och djup ventrombos i Nationella Patientregistret och Dödsorsaksregistret. Vi gjorde ytterligare en sökning, efter ännu fler diagnoskoder, för att hitta insjuknanden i venös trombos som felklassificerats som andra sjukdomar. Sambandet mellan blodsockernivåer, diabetes, alkoholintag, fysisk aktivitet och risken för att senare i livet få en första venös trombos undersökte vi i en prospektiv (framåtblickande), befolkningsbaserad studie som vi kallat Venous thromboEmbolism In Northern Sweden (VEINS)-studien. I VEINS-studien deltog de 108 025 invånare i Västerbottens Län som inte haft någon tidigare venös trombos och som genomgått en hälsoundersökning inom ramen för Västerbottens Hälsoundersökningar under åren 1985 till 2014. I hälsoundersökningen ingick kontroll av vikt, längd, blodtryck och blodsockernivåer. Deltagarna svarade på en enkät om rökning, utbildningsnivå, medicinering, förekomst av diabetes, alkoholintag och fysisk aktivitet. Deltagarna var 30 till 60 år gamla vid studien start. Studiedeltagarna följdes inom ramen för studien från hälsoundersökningen tills de insjuknade i venös trombos, dog, flyttade från området eller fram tills studiens slut 5:e september 2014. Personer i studiegruppen som fått en venös trombos identifierades genom sökning efter diagnoskoder för venös trombos i diagnosregister. Riktigheten i diagnoserna kontrollerades genom granskning av svar på röntgenundersökningar och medicinska journaler.

Resultat: I Västerbottens Län fick varje år 137 av 100 000 vuxna venös trombos för första gången. De vanligaste bidragande faktorerna till att personer fick venös trombos var att de nyligen legat på sjukhus eller hade en cancersjukdom. Av alla personer med en diagnoskod för lungemboli i ett sjukvårdsregister var diagnosen korrekt hos 81%. För djup ventrombos var motsvarande siffra 59%. En av hundra personer med lungemboli hade inte en diagnoskod för lungemboli i ett sjukvårdsregister. För djup ventrombos var motsvarande siffra sexton av hundra. I VEINS-studien insjuknade 2054 studiedeltagare i venös trombos för första gången. Totalt följdes studiedeltagarna i 1,5 miljoner personår. Deltagare med högre fasteblodsocker, högre blodsockervärde taget två timmar efter intag av en sockerlösning och deltagare med diabetes hade högre risk för venös trombos än andra deltagare. Efter att dessa analyser korrigerats för andra faktorer som har samband med blodsockervärden och diabetes och som kan ge ökad risk för venös trombos (störfaktorer), till exempel ålder och övervikt, fanns det inte längre något samband mellan blodsockervärden, diabetes och risk att drabbas av venös trombos. Det fanns ett samband mellan alkoholintag, mätt som antal standardglas alkohol en studiedeltagare drack per vecka, och ökad risk för venös trombos hos män. Det fanns också ett samband mellan alkoholberoende och ökad risk för venös trombos hos män. Dessa fynd kvarstod efter korrigering för möjliga störfaktorer. Vi såg inget samband mellan alkoholintag eller alkoholberoende och ökad risk för venös trombos hos kvinnor. Kvinnor som idrottade på fritiden minst en gång i veckan hade en lägre risk för att få en venös trombos jämfört med kvinnor som mer sällan eller inte alls idrottade på fritiden. Kvinnor med ett fysiskt aktivt arbete hade också lägre risk för venös trombos jämfört med kvinnor med ett mer stillasittande arbete. Hos män såg vi inget tydligt samband mellan fysisk aktivitet på fritiden eller i arbetet och risk för venös trombos.

Slutsatser: Venös trombos är en vanlig kärlsjukdom som drabbar kring 280 vuxna i Västerbotten varje år. Lungembolidiagnoser i sjukvårdsregister håller acceptabel kvalitet och skulle kunna användas i registerstudier. Diagnoser avseende djup ventrombos i sjukvårdsregister håller lägre kvalitet. Det finns inget samband mellan blodsockernivåer, diabetes och risk för venös trombos. Män med högt alkoholintag eller alkoholberoende har högre risk för venös trombos. Kvinnor med hög fysisk aktivitet på fritiden eller i arbetet har lägre risk för venös trombos.

sted, utgiver, år, opplag, sider
Umeå: Umeå University, 2019. s. 107
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 2024
Emneord
Venous thromboembolism, venous thrombosis, deep vein thrombosis, pulmonary embolism, incidence, risk markers, diabetes, glucose, alcohol consumption, alcohol dependence, physical activity
HSV kategori
Forskningsprogram
medicin
Identifikatorer
urn:nbn:se:umu:diva-158474 (URN)978-91-7855-041-8 (ISBN)
Disputas
2019-05-24, Forumsalen, Campus Skellefteå, Skellefteå, 13:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2019-05-03 Laget: 2019-04-28 Sist oppdatert: 2019-08-20bibliografisk kontrollert
Johansson, M., Johansson, L., Wennberg, P. & Lind, M. (2019). Physical activity and risk of first-time venous thromboembolism. European Journal of Preventive Cardiology, 26(11), 1181-1187
Åpne denne publikasjonen i ny fane eller vindu >>Physical activity and risk of first-time venous thromboembolism
2019 (engelsk)Inngår i: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 26, nr 11, s. 1181-1187Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Physical activity may have a protective effect against venous thromboembolism (VTE). The aim of this study was to investigate the association between leisure time physical activity, occupational physical activity, and the risk of VTE in men and women separately.

Methods: The population-based, prospective Venous thromboEmbolism In Northern Sweden (VEINS) cohort study included 108,025 participants of health examinations between 1985 and 2014. Physical activity data were collected by questionnaire. Participants were followed from health examination to first-time VTE event, death, emigration or the end of the study. All VTE events were validated by reviewing medical records and radiology reports.

Results: During 1,496,669 person-years, 2054 participants experienced VTE. Women who performed leisure time physical activity at least once a week had a lower risk of first-time VTE (hazard ratio (HR) 0.83; 95% confidence interval (CI) 0.71–0.98 after adjustments) compared with women with less or no physical activity. Furthermore, women with high occupational physical activity also had a lower risk of VTE (HR 0.85; 95% CI 0.74–0.98). In men, there was no consistent association between either measure of physical activity and the risk of VTE.

Conclusion: We found an association between increased physical activity and a lower risk of first-time VTE in women.

sted, utgiver, år, opplag, sider
Sage Publications, 2019
Emneord
Venous thromboembolism, exercise, physical activity, venous thrombosis
HSV kategori
Forskningsprogram
medicin
Identifikatorer
urn:nbn:se:umu:diva-156241 (URN)10.1177/2047487319829310 (DOI)000472573700010 ()30727768 (PubMedID)2-s2.0-85061651499 (Scopus ID)
Forskningsfinansiär
Västerbotten County Council
Tilgjengelig fra: 2019-03-01 Laget: 2019-03-01 Sist oppdatert: 2019-08-20bibliografisk kontrollert
Johansson, M., Lind, M., Jansson, J.-H., Fhärm, E. & Johansson, L. (2018). Fasting plasma glucose, oral glucose tolerance test, and the risk of first-time venous thromboembolism. A report from the VEINS cohort study. Thrombosis Research, 165, 86-94
Åpne denne publikasjonen i ny fane eller vindu >>Fasting plasma glucose, oral glucose tolerance test, and the risk of first-time venous thromboembolism. A report from the VEINS cohort study
Vise andre…
2018 (engelsk)Inngår i: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 165, s. 86-94Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Introduction: It remains unclear whether high plasma glucose levels are associated with venous thromboembolism (VTE). This study investigated the association between fasting plasma glucose (FPG), oral glucose tolerance test (two-hour post-load plasma glucose (2HPG)), diabetes, and VTE. Materials and methods: The population-based, prospective Venous thromboEmbolism In Northern Sweden (VEINS) cohort study included 108,025 residents of Vasterbotten County in northern Sweden. The participants were aged 30 to 60 years and had no previous VTE events. They were included from 1985 onwards and were followed until a VTE event, death, emigration, or the study end on September 5, 2014. All underwent a health examination that measured weight, height, FPG, and 2HPG and included a questionnaire regarding smoking, education level, and history of diabetes. Potential VTE events were identified by an extensive diagnosis registry search and were validated by reviewing medical records and radiology reports. Results: An objectively verified first-time VTE event was experienced by 2054 participants during 1,496,669 person-years of follow-up. In univariable analysis, there were associations between FPG, 2HPG, diabetes, and the risk of VTE. These associations disappeared after adjustment for potential confounders (age, sex, body mass index, cancer at inclusion, education level, smoking, and hypertension). The adjusted hazard ratios were 1.01 (95% confidence interval 0.83-1.23) for diabetes, 1.01 for each standard deviation of FPG (95% confidence interval 0.97-1.05), and 0.96 for each standard deviation of 2HPG (95% confidence interval 0.91-1.00). Conclusions: There were no independent associations between FPG, 2HPG, diabetes, and future risk of VTE.

sted, utgiver, år, opplag, sider
Elsevier, 2018
Emneord
Venous thromboembolism, Venous thrombosis, Pulmonary embolism, Diabetes, Glucose, Glucose lerance test
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-148754 (URN)10.1016/j.thromres.2018.03.015 (DOI)000432891600015 ()29604434 (PubMedID)
Tilgjengelig fra: 2018-06-19 Laget: 2018-06-19 Sist oppdatert: 2019-08-20bibliografisk kontrollert
Öhman, L., Johansson, M., Jansson, J.-H., Lind, M. & Johansson, L. (2018). Positive predictive value and misclassification of diagnosis of pulmonary embolism and deep vein thrombosis in Swedish patient registries. Clinical Epidemiology, 10, 1215-1221
Åpne denne publikasjonen i ny fane eller vindu >>Positive predictive value and misclassification of diagnosis of pulmonary embolism and deep vein thrombosis in Swedish patient registries
Vise andre…
2018 (engelsk)Inngår i: Clinical Epidemiology, ISSN 1179-1349, E-ISSN 1179-1349, Vol. 10, s. 1215-1221Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: To validate diagnoses of pulmonary embolism (PE) and deep vein thrombosis (DVT) in administrative registries. We also estimated the frequency of misclassified PE and DVT events.

Patients and methods: A registry search for ICD codes representing PE and DVT was performed between 1985 and 2014 in a large population-based cohort in northern Sweden. An additional search using an extended set of ICD codes was performed to identify misclassified events. Diagnoses were validated manually by reviewing medical records and radiology reports.

Results: Searching ICD codes in the National Patient Registry and Cause of Death Registry identified 2,450 participants with a first-time diagnosis of PE or DVT. The positive predictive value (PPV) for a diagnosis of PE or DVT was 80.7% and 59.2%, respectively. For the period of 2009 to 2014, the PPV was higher for PE (85.8%) but lower for DVT (54.1%). Misclassification occurred in 16.4% of DVT events and 1.1% of PE events.

Conclusion: Registry-based data on PE, especially in recent years, are of acceptable quality and can be considered for use in registry-based studies. For DVT, we found that data were of low quality in regards to both PPV and misclassification and should not be used without validation.

sted, utgiver, år, opplag, sider
Dove Medical Press, 2018
Emneord
pulmonary embolism, deep vein thrombosis, positive predictive value, International Classification of diseases, validation
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-152428 (URN)10.2147/CLEP.S177058 (DOI)000445048000002 ()30271217 (PubMedID)
Forskningsfinansiär
Västerbotten County Council
Tilgjengelig fra: 2018-10-04 Laget: 2018-10-04 Sist oppdatert: 2019-08-20bibliografisk kontrollert
Johansson, M., Johansson, L. & Lind, M. (2014). Incidence of venous thromboembolism in northern Sweden (VEINS): a population-based study. Thrombosis Journal, 12, Article ID 6.
Åpne denne publikasjonen i ny fane eller vindu >>Incidence of venous thromboembolism in northern Sweden (VEINS): a population-based study
2014 (engelsk)Inngår i: Thrombosis Journal, ISSN 1477-9560, E-ISSN 1477-9560, Vol. 12, artikkel-id 6Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: The reported incidence of venous thromboembolism (VTE) varies considerably among studies. The primary aim of this study was to describe the incidence of VTE in relation to age and sex. The secondary aim was to describe the risk factor pattern at the time of diagnosis.

METHODS: This retrospective, population-based cohort study included all adult residents in the County of Västerbotten in northern Sweden during the year 2006 (n = 204,836). All potential VTE events were manually validated and classified according to location. The presence of risk factors for VTE at the time of diagnosis was recorded.

RESULTS: We identified 517 adult individuals with potential VTE. Among these, 343 individuals (158 men and 185 women) had a verified VTE event in 2006. The mean incidence was 167 individuals per 100,000 person years; 155 for men and 180 for women. The mean age at diagnosis was 67.6 years in men and 72.5 years in women. The incidence of VTE increased with age. The incidence was highest in women aged 85 years or more. Pulmonary embolism with or without concurrent deep vein thrombosis was diagnosed in 161 individuals (46.9%); lower extremity deep vein thrombosis without concurrent pulmonary embolism was diagnosed in 157 individuals (45.8%); and VTE in another location was diagnosed in 25 individuals (7.3%). The most common risk factors for VTE were recent hospitalization and concurrent malignancy.

CONCLUSION: The incidence of VTE was 167 per 100,000 person years and increased with age. The incidence was highest among older women. Pulmonary embolism was the most common form of VTE; it affected 47% of individuals with VTE. Malignancy and hospitalization were the most prevalent risk factors for VTE.

sted, utgiver, år, opplag, sider
BioMed Central, 2014
Emneord
Venous thromboembolism, Venous thrombosis, Pulmonary embolism, Deep vein thrombosis, Risk factors, Incidence, Epidemiology, Adults
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-120815 (URN)10.1186/1477-9560-12-6 (DOI)24593768 (PubMedID)
Tilgjengelig fra: 2016-05-23 Laget: 2016-05-23 Sist oppdatert: 2019-08-20bibliografisk kontrollert
Johansson, M., Lundberg, B. & Behndig, A. (2007). Optical coherence tomography evaluation of macular edema after phacoemulsification surgery with intracameral mydriatics.. Journal of cataract and refractive surgery, 33(8), 1436-41
Åpne denne publikasjonen i ny fane eller vindu >>Optical coherence tomography evaluation of macular edema after phacoemulsification surgery with intracameral mydriatics.
2007 (engelsk)Inngår i: Journal of cataract and refractive surgery, ISSN 0886-3350, E-ISSN 1873-4502, Vol. 33, nr 8, s. 1436-41Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

PURPOSE: To quantify the macular edema induced by intracameral mydriatics in phacoemulsification surgery. SETTING: University hospital eye clinic, Umeå, Sweden. METHODS: In a randomized study of 22 patients, 11 patients were given 150 muL of a mixture of phenylephrine 1.5% and lidocaine 1% intracamerally for mydriasis and anesthesia. In a control group (n = 11), conventional topical mydriatics and intracameral lidocaine were given. Multiple preoperative, intraoperative, and postoperative variables were recorded. RESULTS: There were no differences in macular edema between the 2 treatments. A correlation was seen between macular edema and impaired visual acuity 1 week postoperatively. On the first postoperative day, a similar correlation was seen between corneal edema and the degree of visual improvement. CONCLUSIONS: Intracameral lidocaine and phenylephrine for mydriasis and anesthesia did not induce more significant macular edema than the standard regimen of topical mydriatics plus intracameral lidocaine. Macular edema limited visual improvement 1 week after phacoemulsification, while corneal edema appeared to have a larger effect immediately after surgery.

HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-20984 (URN)10.1016/j.jcrs.2007.04.027 (DOI)17662438 (PubMedID)
Tilgjengelig fra: 2009-03-31 Laget: 2009-03-31 Sist oppdatert: 2019-01-31
Organisasjoner