Umeå University's logo

umu.sePublikasjoner
Endre søk
Link to record
Permanent link

Direct link
Riklund, Katrine, MD, PhD, ProfessorORCID iD iconorcid.org/0000-0001-5227-8117
Alternativa namn
Publikasjoner (10 av 187) Visa alla publikasjoner
Zarei, M., Wallstén, E., Grefve, J., Söderkvist, K., Gunnlaugsson, A., Sandgren, K., . . . Nyholm, T. (2024). Accuracy of gross tumour volume delineation with [68Ga]-PSMA-PET compared to histopathology for high-risk prostate cancer. Acta Oncologica, 63, 503-510
Åpne denne publikasjonen i ny fane eller vindu >>Accuracy of gross tumour volume delineation with [68Ga]-PSMA-PET compared to histopathology for high-risk prostate cancer
Vise andre…
2024 (engelsk)Inngår i: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 63, s. 503-510Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: The delineation of intraprostatic lesions is vital for correct delivery of focal radiotherapy boost in patients with prostate cancer (PC). Errors in the delineation could translate into reduced tumour control and potentially increase the side effects. The purpose of this study is to compare PET-based delineation methods with histopathology.

MATERIALS AND METHODS: The study population consisted of 15 patients with confirmed high-risk PC intended for prostatectomy. [68Ga]-PSMA-PET/MR was performed prior to surgery. Prostate lesions identified in histopathology were transferred to the in vivo [68Ga]-PSMA-PET/MR coordinate system. Four radiation oncologists manually delineated intraprostatic lesions based on PET data. Various semi-automatic segmentation methods were employed, including absolute and relative thresholds, adaptive threshold, and multi-level Otsu threshold.

RESULTS: The gross tumour volumes (GTVs) delineated by the oncologists showed a moderate level of interobserver agreement with Dice similarity coefficient (DSC) of 0.68. In comparison with histopathology, manual delineations exhibited the highest median DSC and the lowest false discovery rate (FDR) among all approaches. Among semi-automatic approaches, GTVs generated using standardized uptake value (SUV) thresholds above 4 (SUV > 4) demonstrated the highest median DSC (0.41), with 0.51 median lesion coverage ratio, FDR of 0.66 and the 95th percentile of the Hausdorff distance (HD95%) of 8.22 mm.

INTERPRETATION: Manual delineations showed a moderate level of interobserver agreement. Compared to histopathology, manual delineations and SUV > 4 exhibited the highest DSC and the lowest HD95% values. The methods that resulted in a high lesion coverage were associated with a large overestimation of the size of the lesions.

sted, utgiver, år, opplag, sider
MJS Publishing, Medical Journals Sweden, 2024
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-227761 (URN)10.2340/1651-226X.2024.39041 (DOI)001258458500005 ()38912830 (PubMedID)2-s2.0-85197008510 (Scopus ID)
Forskningsfinansiär
Cancerforskningsfonden i NorrlandSwedish Cancer SocietyRegion Västerbotten
Tilgjengelig fra: 2024-07-09 Laget: 2024-07-09 Sist oppdatert: 2024-07-09bibliografisk kontrollert
Grefve, J., Söderkvist, K., Gunnlaugsson, A., Sandgren, K., Jonsson, J., Keeratijarut Lindberg, A., . . . Nyholm, T. (2024). Histopathology-validated gross tumor volume delineations of intraprostatic lesions using PSMA-positron emission tomography/multiparametric magnetic resonance imaging. Physics and Imaging in Radiation Oncology, 31, Article ID 100633.
Åpne denne publikasjonen i ny fane eller vindu >>Histopathology-validated gross tumor volume delineations of intraprostatic lesions using PSMA-positron emission tomography/multiparametric magnetic resonance imaging
Vise andre…
2024 (engelsk)Inngår i: Physics and Imaging in Radiation Oncology, E-ISSN 2405-6316, Vol. 31, artikkel-id 100633Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background and purpose: Dose escalation in external radiotherapy of prostate cancer shows promising results in terms of biochemical disease-free survival. Boost volume delineation guidelines are sparse which may cause high interobserver variability. The aim of this research was to characterize gross tumor volume (GTV) delineations based on multiparametric magnetic resonance imaging (mpMRI) and prostate specific membrane antigen-positron emission tomography (PSMA-PET) in relation to histopathology-validated Gleason grade 4 and 5 regions.

Material and methods: The study participants were examined with [68Ga]PSMA-PET/mpMRI prior to radical prostatectomy. Four radiation oncologists delineated GTVs in 15 study participants, on four different image types; T2-weighted (T2w), diffusion weighted imaging (DWI), dynamic contrast enhanced (DCE) and PSMA-PET scans separately. The simultaneous truth and performance level estimation (STAPLE) algorithm was used to generate combined GTVs. GTVs were subsequently compared to histopathology. We analysed how Dice similarity coefficient (DSC) and lesion coverage are affected by using single versus multiple image types as well as by adding a clinical target volume (CTV) margin.

Results: Median DSC (STAPLE) for different GTVs varied between 0.33 and 0.52. GTVPSMA-PET/mpMRI generated the highest median lesion coverage at 0.66. Combining different image types achieved similar lesion coverage as adding a CTV margin to contours from a single image type, while reducing non-malignant tissue inclusion within the target volume.

Conclusion: The combined use of mpMRI or PSMA-PET/mpMRI shows promise, achieving higher DSC and lesion coverage while minimizing non-malignant tissue inclusion, in comparison to the use of a single image type with an added CTV margin.

sted, utgiver, år, opplag, sider
Elsevier, 2024
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-229329 (URN)10.1016/j.phro.2024.100633 (DOI)2-s2.0-85202586079 (Scopus ID)
Forskningsfinansiär
Swedish Cancer SocietyCancerforskningsfonden i NorrlandProstatacancerförbundetRegion Västerbotten
Tilgjengelig fra: 2024-09-13 Laget: 2024-09-13 Sist oppdatert: 2024-09-13bibliografisk kontrollert
Karalija, N., Papenberg, G., Johansson, J., Wåhlin, A., Salami, A., Andersson, M., . . . Nyberg, L. (2024). Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline. Neurobiology of Aging, 136, 125-132
Åpne denne publikasjonen i ny fane eller vindu >>Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline
Vise andre…
2024 (engelsk)Inngår i: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 136, s. 125-132Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Dopamine decline is suggested to underlie aging-related cognitive decline, but longitudinal examinations of this link are currently missing. We analyzed 5-year longitudinal data for a sample of healthy, older adults (baseline: n = 181, age: 64–68 years; 5-year follow-up: n = 129) who underwent positron emission tomography with 11C-raclopride to assess dopamine D2-like receptor (DRD2) availability, magnetic resonance imaging to evaluate structural brain measures, and cognitive tests. Health, lifestyle, and genetic data were also collected. A data-driven approach (k-means cluster analysis) identified groups that differed maximally in DRD2 decline rates in age-sensitive brain regions. One group (n = 47) had DRD2 decline exclusively in the caudate and no cognitive decline. A second group (n = 72) had more wide-ranged DRD2 decline in putamen and nucleus accumbens and also in extrastriatal regions. The latter group showed significant 5-year working memory decline that correlated with putamen DRD2 decline, along with higher dementia and cardiovascular risk and a faster biological pace of aging. Taken together, for individuals with more extensive DRD2 decline, dopamine decline is associated with memory decline in aging.

Emneord
11C-raclopride, Aging, Dopamine D2-like receptor, Longitudinal, Magnetic resonance imaging, Positron emission tomography, Working memory
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-221540 (URN)10.1016/j.neurobiolaging.2024.02.001 (DOI)38359585 (PubMedID)2-s2.0-85185304249 (Scopus ID)
Forskningsfinansiär
Swedish Research Council, 421-2012-648Swedish Research Council, 2017-02217Swedish Research Council, 2022-01804Umeå UniversityKnut and Alice Wallenberg Foundation, 2015.0277Jonas and Christina af Jochnick FoundationAlzheimerfonden, AF-967710Riksbankens Jubileumsfond, P20-0779Region Västerbotten
Tilgjengelig fra: 2024-03-15 Laget: 2024-03-15 Sist oppdatert: 2024-03-15bibliografisk kontrollert
Papenberg, G., Karalija, N., Johansson, J., Andersson, M., Axelsson, J., Riklund, K., . . . Bäckman, L. (2024). The influence of hippocampal dopamine D2 receptor losses on episodic-memory decline across 5 years is moderated by BDNF and KIBRA polymorphisms. Cortex, 176, 53-61
Åpne denne publikasjonen i ny fane eller vindu >>The influence of hippocampal dopamine D2 receptor losses on episodic-memory decline across 5 years is moderated by BDNF and KIBRA polymorphisms
Vise andre…
2024 (engelsk)Inngår i: Cortex, ISSN 0010-9452, E-ISSN 1973-8102, Vol. 176, s. 53-61Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Losses in dopamine (DA) functioning may contribute to aging-related decline in cognition. Hippocampal DA is necessary for successful episodic memory formation. Previously, we reported that higher DA D2 receptor (D2DR) availability in hippocampus is beneficial for episodic memory only in older carriers of more advantageous genotypes of well-established plasticity-related genetic variations, the brain-derived neurotrophic factor (BDNF, rs6265) and the kidney and brain expressed protein (KIBRA, rs17070145) polymorphisms. Extending our observations to the longitudinal level, the current data show that individuals with one or no beneficial BDNF and KIBRA genotype (n = 80) decline more in episodic memory across five years, without any contribution of losses in hippocampal D2DR availability to memory decline. Although carriers of two beneficial genotypes (n = 39) did not decline overall in episodic memory, losses of hippocampal D2DR availability were predictive of episodic-memory decline among these individuals. Our findings have implications for interventions targeting DA modulation to enhance episodic memory in aging, which may not benefit all older individuals.

sted, utgiver, år, opplag, sider
Elsevier, 2024
Emneord
BNDF, Dopamine D2 receptors, Episodic memory, Inter-individual differences, KIBRA, Longitudinal, [11C]raclopride
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-224932 (URN)10.1016/j.cortex.2024.01.014 (DOI)38749085 (PubMedID)2-s2.0-85192831317 (Scopus ID)
Forskningsfinansiär
Swedish Research CouncilRegion VästerbottenKnut and Alice Wallenberg FoundationTorsten Söderbergs stiftelseRagnar Söderbergs stiftelseJonas and Christina af Jochnick FoundationThe Swedish Brain FoundationRegion VästerbottenMax Planck SocietyGerman Research Foundation (DFG)
Tilgjengelig fra: 2024-05-30 Laget: 2024-05-30 Sist oppdatert: 2024-05-30bibliografisk kontrollert
Renman, D., van Guelpen, B., Anderson, F., Axelsson, J., Riklund, K., Strigård, K., . . . Gylling, B. (2023). Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer. International Journal of Colorectal Disease, 38(1), Article ID 239.
Åpne denne publikasjonen i ny fane eller vindu >>Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer
Vise andre…
2023 (engelsk)Inngår i: International Journal of Colorectal Disease, ISSN 0179-1958, E-ISSN 1432-1262, Vol. 38, nr 1, artikkel-id 239Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: Sarcopenia and myosteatosis, quantified via computed tomography (CT), are associated with poor colorectal cancer outcomes. These body composition estimates can be influenced by physical exercise. We explored the correlation between pre-diagnostic physical exercise, body composition close to diagnosis, and the combined prognosis impact of these factors.

Methods: We studied 519 stage I–III colorectal cancer (CRC) cases diagnosed 2000–2016 with pre-diagnostic self-reported recreational physical exercise data collected in the prospective, population-based Northern Sweden Health and Disease Study, and CT-estimated skeletal muscle index (SMI) or skeletal muscle density (SMD). Risk estimates were calculated by multivariable logistic regression and Cox proportional hazards models.

Results: No association was seen between low pre-diagnostic physical exercise and sarcopenia/myosteatosis in the multivariable model adjusted for age, sex, educational level, tumor stage, and tumor location. In multivariable Cox regression models, the combination of low pre-diagnostic physical exercise and either sarcopenia or myosteatosis at the time of diagnosis was associated with cancer-specific mortality compared to the reference group of high physical exercise combined with no sarcopenia/myosteatosis (adjusted HR 1.94 95% CI 1.00–3.76 for sarcopenia and adjusted HR 2.39 95% CI 1.16–4.94 for myosteatosis).

Conclusions: The combined presence of low pre-diagnostic physical exercise and sarcopenia or myosteatosis was associated with increased CRC-specific mortality. Despite the positive effect on prognosis, physical exercise did not alter body composition estimates at diagnosis, which could indicate attenuation from other factors.

sted, utgiver, år, opplag, sider
Springer Nature, 2023
Emneord
Colorectal cancer, Exercise, Myosteatosis, Physical activity, Sarcopenia
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-215081 (URN)10.1007/s00384-023-04536-0 (DOI)37755537 (PubMedID)2-s2.0-85172659066 (Scopus ID)
Forskningsfinansiär
Cancerforskningsfonden i Norrland, AMP 20-999Visare Norr, 967732Region Västerbotten, ALF RV-968855Region Västerbotten, ALF RV-982739
Tilgjengelig fra: 2023-10-13 Laget: 2023-10-13 Sist oppdatert: 2024-02-08bibliografisk kontrollert
Johansson, J., Nordin, K., Pedersen, R., Karalija, N., Papenberg, G., Andersson, M., . . . Salami, A. (2023). Biphasic patterns of age-related differences in dopamine D1 receptors across the adult lifespan. Cell Reports, 42(9), Article ID 113107.
Åpne denne publikasjonen i ny fane eller vindu >>Biphasic patterns of age-related differences in dopamine D1 receptors across the adult lifespan
Vise andre…
2023 (engelsk)Inngår i: Cell Reports, E-ISSN 2211-1247, Vol. 42, nr 9, artikkel-id 113107Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Age-related alterations in D1-like dopamine receptor (D1DR) have distinct implications for human cognition and behavior during development and aging, but the timing of these periods remains undefined. Enabled by a large sample of in vivo assessments (n = 180, age 20 to 80 years of age, 50% female), we discover that age-related D1DR differences pivot at approximately 40 years of age in several brain regions. Focusing on the most age-sensitive dopamine-rich region, we observe opposing pre- and post-forties interrelations among caudate D1DR, cortico-striatal functional connectivity, and memory. Finally, particularly caudate D1DR differences in midlife and beyond, but not in early adulthood, associate with manifestation of white matter lesions. The present results support a model by which excessive dopamine modulation in early adulthood and insufficient modulation in aging are deleterious to brain function and cognition, thus challenging a prevailing view of monotonic D1DR function across the adult lifespan.

Emneord
aging, cognition, CP: Neuroscience, dopamine D1, functional connectivity, neuromodulation, protracted development
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-214414 (URN)10.1016/j.celrep.2023.113107 (DOI)2-s2.0-85169884676 (Scopus ID)
Forskningsfinansiär
Swedish Research Council, 2016-01936Knut and Alice Wallenberg FoundationRiksbankens Jubileumsfond
Tilgjengelig fra: 2023-09-18 Laget: 2023-09-18 Sist oppdatert: 2024-07-02bibliografisk kontrollert
Santos, J., Foley, S., Andersson, J., Figueiredo, J. P., Hoeschen, C., Damilakis, J., . . . Paulo, G. (2023). Education and training in radiation protection in Europe: results from the EURAMED Rocc-n-Roll project survey. Insights into Imaging, 14(1), Article ID 55.
Åpne denne publikasjonen i ny fane eller vindu >>Education and training in radiation protection in Europe: results from the EURAMED Rocc-n-Roll project survey
Vise andre…
2023 (engelsk)Inngår i: Insights into Imaging, E-ISSN 1869-4101, Vol. 14, nr 1, artikkel-id 55Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: To analyse the existing radiation protection (RP) education and training (E&T) capabilities in the European Union and identify associated needs, problems and challenges.

Method: An online survey was disseminated via the EURAMED Rocc-n-Roll consortium network and prominent medical societies in the field of radiological research. The survey sections analyse the RP E&T during undergraduate, residency/internship and continuous professional development; RP E&T problems and legal implementation. Differences were analysed by European geographic regions, profession, years of professional experience and main area of practice/research.

Results: The majority of the 550 respondents indicated that RP topics are part of undergraduate curricula in all courses for their profession and country (55%); however, hands-on practical training is not included according to 30% of the respondents. The lack of E&T, practical aspects in current E&T, and mandatory continuing E&T were considered the major problems. The legal requirement that obtained higher implementation score was the inclusion of the practical aspects of medical radiological procedures on education (86%), and lower score was obtained for the inclusion of RP E&T on medical and dental school curriculums (61%).

Conclusions: A heterogeneity in RP E&T during undergraduate, residency/internship and continuous professional development is evident across Europe. Differences were noted per area of practice/research, profession, and European geographic region. A large variation in RP E&T problem rating was also obtained.

sted, utgiver, år, opplag, sider
Springer, 2023
Emneord
Education and training, European Basic Safety Standards, Medical exposure, Radiation protection
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-206948 (URN)10.1186/s13244-023-01398-6 (DOI)2-s2.0-85152565595 (Scopus ID)
Tilgjengelig fra: 2023-04-27 Laget: 2023-04-27 Sist oppdatert: 2024-04-05bibliografisk kontrollert
Sandgren, K., Strandberg, S., Jonsson, J., Grefve, J., Keeratijarut Lindberg, A., Nilsson, E., . . . Riklund, K. (2023). Histopathology-validated lesion detection rates of clinically significant prostate cancer with mpMRI, [68Ga]PSMA-11-PET and [11C]Acetate-PET. Nuclear medicine communications, 44(11), 997-1004
Åpne denne publikasjonen i ny fane eller vindu >>Histopathology-validated lesion detection rates of clinically significant prostate cancer with mpMRI, [68Ga]PSMA-11-PET and [11C]Acetate-PET
Vise andre…
2023 (engelsk)Inngår i: Nuclear medicine communications, ISSN 0143-3636, E-ISSN 1473-5628, Vol. 44, nr 11, s. 997-1004Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective: PET/CT and multiparametric MRI (mpMRI) are important diagnostic tools in clinically significant prostate cancer (csPC). The aim of this study was to compare csPC detection rates with [68Ga]PSMA-11-PET (PSMA)-PET, [11C] Acetate (ACE)-PET, and mpMRI with histopathology as reference, to identify the most suitable imaging modalities for subsequent hybrid imaging. An additional aim was to compare inter-reader variability to assess reproducibility.

Methods: During 2016–2019, all study participants were examined with PSMA-PET/mpMRI and ACE-PET/CT prior to radical prostatectomy. PSMA-PET, ACE-PET and mpMRI were evaluated separately by two observers, and were compared with histopathology-defined csPC. Statistical analyses included two-sided McNemar test and index of specific agreement.

Results: Fifty-five study participants were included, with 130 histopathological intraprostatic lesions >0.05 cc. Of these, 32% (42/130) were classified as csPC with ISUP grade ≥2 and volume >0.5 cc. PSMA-PET and mpMRI showed no difference in performance (P = 0.48), with mean csPC detection rate of 70% (29.5/42) and 74% (31/42), respectively, while with ACE-PET the mean csPC detection rate was 37% (15.5/42). Interobserver agreement was higher with PSMA-PET compared to mpMRI [79% (26/33) vs 67% (24/38)]. Including all detected lesions from each pair of observers, the detection rate increased to 90% (38/42) with mpMRI, and 79% (33/42) with PSMA-PET.

Conclusion: PSMA-PET and mpMRI showed high csPC detection rates and superior performance compared to ACE-PET. The interobserver agreement indicates higher reproducibility with PSMA-PET. The combined result of all observers in both PSMA-PET and mpMRI showed the highest detection rate, suggesting an added value of a hybrid imaging approach.

sted, utgiver, år, opplag, sider
Lippincott Williams & Wilkins, 2023
Emneord
acetate-PET, detection rate, intraprostatic lesion, multiparametric MRI, prostate cancer, PSMA-PET
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-216125 (URN)10.1097/MNM.0000000000001743 (DOI)001083841200009 ()37615497 (PubMedID)2-s2.0-85174936230 (Scopus ID)
Forskningsfinansiär
Swedish Cancer SocietyVästerbotten County Council
Tilgjengelig fra: 2023-11-06 Laget: 2023-11-06 Sist oppdatert: 2024-07-02bibliografisk kontrollert
Nilsson, E., Sandgren, K., Grefve, J., Jonsson, J., Axelsson, J., Keeratijarut Lindberg, A., . . . Nyholm, T. (2023). The grade of individual prostate cancer lesions predicted by magnetic resonance imaging and positron emission tomography. Communications Medicine, 3(1), Article ID 164.
Åpne denne publikasjonen i ny fane eller vindu >>The grade of individual prostate cancer lesions predicted by magnetic resonance imaging and positron emission tomography
Vise andre…
2023 (engelsk)Inngår i: Communications Medicine, E-ISSN 2730-664X, Vol. 3, nr 1, artikkel-id 164Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Multiparametric magnetic resonance imaging (mpMRI) and positron emission tomography (PET) are widely used for the management of prostate cancer (PCa). However, how these modalities complement each other in PCa risk stratification is still largely unknown. We aim to provide insights into the potential of mpMRI and PET for PCa risk stratification.

Methods: We analyzed data from 55 consecutive patients with elevated prostate-specific antigen and biopsy-proven PCa enrolled in a prospective study between December 2016 and December 2019. [68Ga]PSMA-11 PET (PSMA-PET), [11C]Acetate PET (Acetate-PET) and mpMRI were co-registered with whole-mount histopathology. Lower- and higher-grade lesions were defined by International Society of Urological Pathology (ISUP) grade groups (IGG). We used PET and mpMRI data to differentiate between grades in two cases: IGG 3 vs. IGG 2 (case 1) and IGG ≥ 3 vs. IGG ≤ 2 (case 2). The performance was evaluated by receiver operating characteristic (ROC) analysis.

Results: We find that the maximum standardized uptake value (SUVmax) for PSMA-PET achieves the highest area under the ROC curve (AUC), with AUCs of 0.72 (case 1) and 0.79 (case 2). Combining the volume transfer constant, apparent diffusion coefficient and T2-weighted images (each normalized to non-malignant prostatic tissue) results in AUCs of 0.70 (case 1) and 0.70 (case 2). Adding PSMA-SUVmax increases the AUCs by 0.09 (p < 0.01) and 0.12 (p < 0.01), respectively.

Conclusions: By co-registering whole-mount histopathology and in-vivo imaging we show that mpMRI and PET can distinguish between lower- and higher-grade prostate cancer, using partially discriminative cut-off values.

sted, utgiver, år, opplag, sider
Springer Nature, 2023
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-224145 (URN)10.1038/s43856-023-00394-7 (DOI)001103117100002 ()37945817 (PubMedID)
Forskningsfinansiär
Swedish Cancer Society, 21 1594 Pj
Tilgjengelig fra: 2024-05-08 Laget: 2024-05-08 Sist oppdatert: 2024-05-13bibliografisk kontrollert
Farnsworth von Cederwald, B., Johansson, J., Riklund, K., Karalija, N. & Boraxbekk, C.-J. (2023). White matter lesion load determines exercise-induced dopaminergic plasticity and working memory gains in aging. Translational Psychiatry, 13(1), Article ID 28.
Åpne denne publikasjonen i ny fane eller vindu >>White matter lesion load determines exercise-induced dopaminergic plasticity and working memory gains in aging
Vise andre…
2023 (engelsk)Inngår i: Translational Psychiatry, E-ISSN 2158-3188, Vol. 13, nr 1, artikkel-id 28Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Age-related dopamine reductions have been suggested to contribute to maladaptive working memory (WM) function in older ages. One promising intervention approach is to increase physical activity, as this has been associated with plasticity of the striatal dopamine system and WM improvements, however with individual differences in efficacy. The present work focused on the impact of individual differences in white-matter lesion burden upon dopamine D2-like receptor (DRD2) availability and WM changes in response to a 6 months physical activity intervention. While the intervention altered striatal DRD2 availability and WM performance in individuals with no or only mild lesions (p < 0.05), no such effects were found in individuals with moderate-to-severe lesion severity (p > 0.05). Follow-up analyses revealed a similar pattern for processing speed, but not for episodic memory performance. Linear analyses further revealed that lesion volume (ml) at baseline was associated with reduced DRD2 availability (r = −0.41, p < 0.05), and level of DRD2 change (r = 0.40, p < 0.05). Taken together, this study underlines the necessity to consider cerebrovascular health in interventions with neurocognitive targets. Future work should assess whether these findings extend beyond measures of DRD2 availability and WM.

sted, utgiver, år, opplag, sider
Springer Nature, 2023
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-204468 (URN)10.1038/s41398-022-02270-9 (DOI)000924365700002 ()36720847 (PubMedID)2-s2.0-85147098951 (Scopus ID)
Forskningsfinansiär
Swedish Research Council, 2012-00530Region VästerbottenUmeå UniversityThe Kamprad Family FoundationThe Swedish Brain Foundation
Tilgjengelig fra: 2023-02-17 Laget: 2023-02-17 Sist oppdatert: 2024-01-17bibliografisk kontrollert
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0001-5227-8117