Umeå University's logo

umu.sePublikasjoner
Endre søk
Link to record
Permanent link

Direct link
Alternativa namn
Publikasjoner (10 av 54) Visa alla publikasjoner
Kristiansen, M., Holmlund, P., Linden, C., Eklund, A. & Jóhannesson, G. (2024). Author response: deficient optic nerve sheath occlusion in ntg patients: optic nerve damage due to translaminar pressure imbalance, glymphatic failure, or both? [Letter to the editor]. Investigative Ophthalmology and Visual Science, 65(5), Article ID 19.
Åpne denne publikasjonen i ny fane eller vindu >>Author response: deficient optic nerve sheath occlusion in ntg patients: optic nerve damage due to translaminar pressure imbalance, glymphatic failure, or both?
Vise andre…
2024 (engelsk)Inngår i: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 65, nr 5, artikkel-id 19Artikkel i tidsskrift, Letter (Annet vitenskapelig) Published
sted, utgiver, år, opplag, sider
Association for Research in Vision and Ophthalmology (ARVO), 2024
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-224851 (URN)10.1167/iovs.65.5.19 (DOI)38717422 (PubMedID)2-s2.0-85192594501 (Scopus ID)
Tilgjengelig fra: 2024-06-11 Laget: 2024-06-11 Sist oppdatert: 2024-06-13bibliografisk kontrollert
Rasmuson, E., Linden, C., Lundberg, B. & Jóhannesson, G. (2024). Changes in intraocular pressure during the first 24 h after transscleral cyclophotocoagulation. Acta Ophthalmologica
Åpne denne publikasjonen i ny fane eller vindu >>Changes in intraocular pressure during the first 24 h after transscleral cyclophotocoagulation
2024 (engelsk)Inngår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768Artikkel i tidsskrift (Fagfellevurdert) Epub ahead of print
Abstract [en]

Aims: To estimate the changes in intraocular pressure (IOP) during the first 24 h after transscleral cyclophotocoagulation (TCP).

Methods: A prospective single-centre study, where patients with glaucoma destined for treatment with TCP were asked for participation. The IOP was measured prior to TCP and at 1, 2, 4, 6 and 24 h post-TCP. An IOP spike was defined as an elevation of IOP of ≥5 mmHg compared with baseline. The visual acuity (VA) was examined at baseline and after 24 h.

Results: The mean IOP prior to TCP in 58 eyes of 58 patients was 26.2 (±8.9 SD) mmHg. Twenty-three eyes (40%) experienced an IOP spike at some examination timepoint during the first 24 h. The mean value of the IOP spike was 12.1 (±6.9) mmHg. Fifty-six per cent of the eyes with pseudoexfoliation glaucoma (PEXG) experienced an IOP spike, and 16% had an IOP spike ≥20 mmHg. The IOP was significantly reduced at the 24 h examination by 8.1 (±7.8) mmHg (n = 58). The VA 24 h after TCP was unchanged compared with baseline.

Conclusion: Clinically significant IOP spikes were common in the first 24 h post-TCP. Almost one in five eyes had an increase of 10 mmHg and in almost one in 10 eyes, the IOP increase was 20 mmHg or higher. Eyes with PEXG had a higher occurrence of IOP spikes and displayed a greater magnitude of IOP elevation. Prophylactic post-operative IOP-lowering medication should be considered to prevent further glaucoma damage.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2024
Emneord
glaucoma, glaucoma treatment, intraocular pressure, laser treatment, prospective study, transscleral cyclophotocoagulation
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-221046 (URN)10.1111/aos.16652 (DOI)2-s2.0-85184467199 (Scopus ID)
Forskningsfinansiär
Knut and Alice Wallenberg FoundationRegion Västerbotten
Tilgjengelig fra: 2024-02-21 Laget: 2024-02-21 Sist oppdatert: 2024-02-21
Jóhannesson, G., Stille, U., Taube, A. B., Karlsson, M., Kalaboukhova, L., Bergström, A., . . . Lindén, C. (2024). Guidelines for the management of open-angle glaucoma: national program area eye diseases, national working group glaucoma. Acta Ophthalmologica, 102(2), 135-150
Åpne denne publikasjonen i ny fane eller vindu >>Guidelines for the management of open-angle glaucoma: national program area eye diseases, national working group glaucoma
Vise andre…
2024 (engelsk)Inngår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 102, nr 2, s. 135-150Artikkel i tidsskrift (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
John Wiley & Sons, 2024
Emneord
glaucoma, guidelines, management, Sweden
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-219315 (URN)10.1111/aos.16599 (DOI)001134659800001 ()38164112 (PubMedID)2-s2.0-85181192008 (Scopus ID)
Tilgjengelig fra: 2024-01-15 Laget: 2024-01-15 Sist oppdatert: 2024-04-30bibliografisk kontrollert
Barkander, A., Nolan, A. S., Jóhannesson, G. & Economou, M. A. (2024). Influence of laser trabeculoplasty on combined phacoemulsification/Kahook Dual Blade goniotomy. Clinical Ophthalmology, 18, 1811-1817
Åpne denne publikasjonen i ny fane eller vindu >>Influence of laser trabeculoplasty on combined phacoemulsification/Kahook Dual Blade goniotomy
2024 (engelsk)Inngår i: Clinical Ophthalmology, ISSN 1177-5467, E-ISSN 1177-5483, Vol. 18, s. 1811-1817Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: To investigate the influence of laser trabeculoplasty (LTP) on subsequent surgery with combined phacoemulsification/ Kahook Dual Blade goniotomy (phaco-KDB) in patients with open-angle glaucoma or intraocular hypertension.

Patients and Methods: Patients undergoing phaco-KDB between 2019 and 2021 were divided into previously LTP treated and previously non-LTP treated, and LTP-treatment included argon laser trabeculoplasty (ALT) and selective laser trabeculoplasty (SLT). The primary goal was to investigate if previous LTP influenced later surgical outcome of phaco-KDB. The secondary goal was to investigate if the outcome of LTP could be predictive of the outcome of subsequent phaco-KDB. We also compared IOP-and medication reductions between LTP and non-LTP treated patients.

Results: A total of 111 LTP treated patients were compared to 139 non-LTP treated patients. In LTP treated patients, surgical success of phaco-KDB was 82.9%, compared to 88.5% in non-LTP treated patients (P=0.20). Reductions in IOP and medications were similar between groups. Furthermore, within the LTP group, patients with successful LTP-treatment had a subsequent surgical success of phaco-KDB in 80.7%, compared to 83.0% in patients with unsuccessful LTP-treatment (P=0.765).

Conclusion: Previous LTP treatment does not predict the outcome of phaco-KDB. Furthermore, no correlation was found between the LTP effect and a later surgical success of phaco-KDB.

sted, utgiver, år, opplag, sider
Dove Medical Press, 2024
Emneord
glaucoma, goniotomy, Kahook Dual Blade, laser trabeculoplasty, phacoemulsification
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-227830 (URN)10.2147/OPTH.S468809 (DOI)001253260900001 ()38948342 (PubMedID)2-s2.0-85197387170 (Scopus ID)
Forskningsfinansiär
Region Jämtland HärjedalenRegion VästerbottenKnut and Alice Wallenberg Foundation
Tilgjengelig fra: 2024-07-12 Laget: 2024-07-12 Sist oppdatert: 2024-07-12bibliografisk kontrollert
Rasmuson, E., Bengtsson, B., Linden, C., Heijl, A., Aspberg, J., Andersson-Geimer, S. & Jóhannesson, G. (2024). Long-term follow-up of laser trabeculoplasty in multi-treated glaucoma patients. Acta Ophthalmologica, 102(2), 179-185
Åpne denne publikasjonen i ny fane eller vindu >>Long-term follow-up of laser trabeculoplasty in multi-treated glaucoma patients
Vise andre…
2024 (engelsk)Inngår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 102, nr 2, s. 179-185Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: To evaluate the long-term effect of laser trabeculoplasty (LTP) in patients randomized to multi-treatment in the Glaucoma Intensive Treatment Study (GITS).

Methods: Patients with untreated newly diagnosed open-angle glaucoma were treated with three intraocular pressure (IOP)-lowering substances for 1 week and then 360 degrees argon or selective LTP was performed. IOP was measured just before LTP and repeatedly during the 60-month study period. Our previous report on 12 months follow-up data revealed no effect of LTP in eyes having an IOP <15 mmHg before the laser treatment.

Results: Before LTP, the mean IOP +/- standard deviation in all 152 study-eyes of 122 multi-treated patients was 14.0 +/- 3.5 mmHg. Three eyes of three deceased patients were lost to follow-up during the 60 months. After exclusion of eyes that received increased therapy during follow-up, the IOP was significantly reduced at all visits up to 48 months in eyes with pre-LTP IOP >= 15 mmHg; 2.6 +/- 3.1 mmHg at 1 month and 1.7 +/- 2.8 mmHg at 48 months, n = 56 and 48, respectively. No significant IOP reduction was seen in eyes with pre-LTP IOP <15 mmHg. Seven eyes, i.e., <13%, with pre-LTP IOP >= 15 mmHg at baseline had required increased IOP-lowering therapy at 48 months.

Conclusion: LTP performed in multi-treated patients may provide a useful IOP reduction that is maintained over several years. This was true on a group level when the initial IOP was >= 15 mmHg, but if the pre-laser IOP was lower than that, chances of LTP success were small.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2024
Emneord
ALT, intraocular pressure, laser trabeculoplasty, long-term follow-up, multi-therapy, open-angle glaucoma, pseudoexfoliation glaucoma, SLT
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-206002 (URN)10.1111/aos.15718 (DOI)001001069900001 ()37278271 (PubMedID)2-s2.0-85161487517 (Scopus ID)
Forskningsfinansiär
Kronprinsessan Margaretas MinnesfondUmeå UniversityLund UniversityEye FoundationKonung Gustaf V:s och Drottning Victorias FrimurarestiftelseThe Swedish Medical AssociationSwedish Society for Medical Research (SSMF)Västerbotten County Council
Merknad

Originally included in thesis in manuscript form.

Tilgjengelig fra: 2023-03-27 Laget: 2023-03-27 Sist oppdatert: 2024-05-06bibliografisk kontrollert
Huang, L., Fallahzadeh, F. & Jóhannesson, G. (2024). Occult GCA: a rare variant of giant cell arteritis. Acta Ophthalmologica
Åpne denne publikasjonen i ny fane eller vindu >>Occult GCA: a rare variant of giant cell arteritis
2024 (engelsk)Inngår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768Artikkel i tidsskrift (Fagfellevurdert) Epub ahead of print
sted, utgiver, år, opplag, sider
John Wiley & Sons, 2024
Emneord
AION, arteritis, bilateral, cell, Giant, occult, temporal, visual
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-227589 (URN)10.1111/aos.16731 (DOI)001252773400001 ()2-s2.0-85196669855 (Scopus ID)
Tilgjengelig fra: 2024-07-01 Laget: 2024-07-01 Sist oppdatert: 2024-07-01
Otmani, A., Jóhannesson, G., Brautaset, R., Tribble, J. R. & Williams, P. A. (2024). Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume. Acta neuropathologica communications, 12(1), Article ID 37.
Åpne denne publikasjonen i ny fane eller vindu >>Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume
Vise andre…
2024 (engelsk)Inngår i: Acta neuropathologica communications, E-ISSN 2051-5960, Vol. 12, nr 1, artikkel-id 37Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Leber’s hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressive retinal ganglion cell dysfunction usually in the absence of extra-ophthalmic symptoms. There are no long-term neuroprotective agents for LHON. Oral nicotinamide provides a robust neuroprotective effect against mitochondrial and metabolic dysfunction in other retinal injuries. We explored the potential for nicotinamide to protect mitochondria in LHON by modelling the disease in mice through intravitreal injection of the Complex I inhibitor rotenone. Using MitoV mice expressing a mitochondrial-tagged YFP in retinal ganglion cells we assessed mitochondrial morphology through super-resolution imaging and digital reconstruction. Rotenone induced Complex I inhibition resulted in retinal ganglion cell wide mitochondrial loss and fragmentation. This was prevented by oral nicotinamide treatment. Mitochondrial ultrastructure was quantified by transition electron microscopy, demonstrating a loss of cristae density following rotenone injection, which was also prevented by nicotinamide treatment. These results demonstrate that nicotinamide protects mitochondria during Complex I dysfunction. Nicotinamide has the potential to be a useful treatment strategy for LHON to limit retinal ganglion cell degeneration.

sted, utgiver, år, opplag, sider
BioMed Central (BMC), 2024
Emneord
Mitochondria, Neurodegeneration, Nicotinamide, Optic nerve, Retina, Retina ganglion cells
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-222236 (URN)10.1186/s40478-024-01724-z (DOI)1176539900001 ()38429841 (PubMedID)2-s2.0-85186470382 (Scopus ID)
Forskningsfinansiär
Swedish Research Council, 2022–00799Karolinska InstituteStiftelsen Kronprinsessan Margaretas arbetsnämnd för synskadade
Tilgjengelig fra: 2024-03-18 Laget: 2024-03-18 Sist oppdatert: 2024-03-18bibliografisk kontrollert
Azuara-Blanco, A., McCorry, N., Tatham, A. J., Georgoulas, S., Founti, P., Schweitzer, C., . . . Topouzis, F. (2023). European Glaucoma Society research priorities for glaucoma care. British Journal of Ophthalmology
Åpne denne publikasjonen i ny fane eller vindu >>European Glaucoma Society research priorities for glaucoma care
Vise andre…
2023 (engelsk)Inngår i: British Journal of Ophthalmology, ISSN 0007-1161, E-ISSN 1468-2079Artikkel i tidsskrift (Fagfellevurdert) Epub ahead of print
Abstract [en]

Background/Aims: The goal of health research is to improve patients care and outcomes. Thus, it is essential that research addresses questions that are important to patients and clinicians. The aim of this study was to develop a list of priorities for glaucoma research involving stakeholders from different countries in Europe.

Methods: We used a three-phase method, including a two-round electronic Delphi survey and a workshop. The clinician and patient electronic surveys were conducted in parallel and independently. For phase I, the survey was distributed to patients from 27 European countries in 6 different languages, and to European Glaucoma Society members, ophthalmologists with expertise in glaucoma care, asking to name up to five research priorities. During phase II, participants were asked to rank the questions identified in phase I using a Likert scale. Phase III was a 1 day workshop with patients and clinicians. The purpose was to make decisions about the 10 most important research priorities using the top 20 priorities identified by patients and clinicians.

Results: In phase I, 308 patients and 150 clinicians were involved. In phase II, the highest-ranking priority for both patients and clinicians was € treatments to restore vision'. In phase III, eight patients and four clinicians were involved. The top three priorities were € treatments to stop sight loss', € treatments to restore vision' and € improved detection of worsening glaucoma'.

Conclusion: We have developed a list of priorities for glaucoma research involving clinicians and patients from different European countries that will help guide research efforts and investment.

sted, utgiver, år, opplag, sider
BMJ Publishing Group Ltd, 2023
Emneord
clinical trial, diagnostic tests/investigation, glaucoma, treatment medical, treatment surgery
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-217025 (URN)10.1136/bjo-2023-323648 (DOI)001094788800001 ()37923373 (PubMedID)2-s2.0-85176602136 (Scopus ID)
Tilgjengelig fra: 2023-11-23 Laget: 2023-11-23 Sist oppdatert: 2024-01-15
Barkander, A., Economou, M. A. & Jóhannesson, G. (2023). Kahook dual-blade goniotomy with and without phacoemulsification in medically uncontrolled glaucoma. Clinical Ophthalmology, 17, 1385-1394
Åpne denne publikasjonen i ny fane eller vindu >>Kahook dual-blade goniotomy with and without phacoemulsification in medically uncontrolled glaucoma
2023 (engelsk)Inngår i: Clinical Ophthalmology, ISSN 1177-5467, E-ISSN 1177-5483, Vol. 17, s. 1385-1394Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: To evaluate the 2-year efficacy and safety of Kahook dual-blade (KDB) goniotomy in patients with medically uncontrolled glaucoma.

Methods: This was a retrospective case-series study of 90 consecutive patients with primary open-angle glaucoma (POAG) or pseudoexfoliation glaucoma (PEXG) that underwent KDB goniotomy alone (KDB-alone group) or KDB goniotomy in combination with phacoemulsification (KDB-phaco group) during 2019–2020. All patients were uncontrolled on three or more medications. Surgical success was defined as an IOP reduction ≥20% and/or a reduction of one or more medications at 24 months. We also report IOP levels and number of medications from baseline to 24 months, as well as the need for further glaucoma interventions.

Results: At 24 months, mean IOP had reduced from 24.8±8.3 to 15.0±5.3 mmHg in the KDB-alone group (P<0.001) and from 22.3 ±5.8 to 13.9±3.0 mmHg in the KDB-phaco group (P<0.001). Medications had reduced from 3.5±0.6 to 3.1±0.9 in the KDB-alone group (P=0.047) and from 3.3±0.5 to 2.3±1.1 in the KDB-phaco group (P<0.001). An IOP reduction ≥20% and/or a reduction with one or more medications was achieved by 47% of eyes in the KDB-alone group and by 76% of eyes in the KDB-phaco group. Eyes with PEXG and POAG responded equally well to the success criteria. During the 24-month follow-up, additional glaucoma surgery or transscleral photocoagulation was performed in 28% of eyes in the KDB-alone group and in 12% of eyes in the KDB-phaco group.

Conclusion: In patients with medically uncontrolled glaucoma, KDB had a significant IOP-lowering effect after 24 months, but success rates were higher when KDB was performed in combination with cataract surgery compared to stand-alone treatment.

sted, utgiver, år, opplag, sider
Dove press, 2023
Emneord
Kahook dual blade, medically uncontrolled glaucoma, phacoemulsification, primary open-angle glaucoma, pseudoexfoliation glaucoma
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-209192 (URN)10.2147/OPTH.S409375 (DOI)000992915500001 ()37204995 (PubMedID)2-s2.0-85160225264 (Scopus ID)
Forskningsfinansiär
Region Jämtland HärjedalenRegion VästerbottenKnut and Alice Wallenberg Foundation
Tilgjengelig fra: 2023-06-12 Laget: 2023-06-12 Sist oppdatert: 2024-01-15bibliografisk kontrollert
Gustavsson, S. T., Enz, T. J., Tribble, J. R., Nilsson, M., Lindqvist, A., Linden, C., . . . Jóhannesson, G. (2023). Nicotinamide prevents retinal vascular dropout in a rat model of ocular hypertension and supports ocular blood supply in glaucoma patients. Investigative Ophthalmology and Visual Science, 64, Article ID 34.
Åpne denne publikasjonen i ny fane eller vindu >>Nicotinamide prevents retinal vascular dropout in a rat model of ocular hypertension and supports ocular blood supply in glaucoma patients
Vise andre…
2023 (engelsk)Inngår i: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 64, artikkel-id 34Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

PURPOSE. To investigate whether nicotinamide (NAM) modulates retinal vasculature in glaucoma.

METHODS. This was a prospective controlled clinical trial investigating animal and human histopathology. Participants included normotensive and ocular hypertensive rats, postmortem human ocular tissue, glaucoma patients (n = 90), and healthy controls (n = 30). The study utilized histopathology, computer-assisted retinal vasculature analysis, optical coherence tomography angiography (OCTA), and NAM treatment. The main outcome measures included retinal vascular parameters in rats as assessed by AngioTool; retinal vasculature integrity in rats and humans as assessed by histopathology, antibody-staining, and ImageJ-based measurements; and retinal perfusion density (PD) and flux index in humans as assessed by OCTA.

RESULTS. A number of vessel parameters were altered in ocular hypertension/glaucoma compared to healthy controls. NAM treatment improved the retinal vasculature in ocular hypertensive rats, with an increase in mean vessel area, percentage area covered by vessels, total vessel length, total junctions, and junction density as assessed by AngioTool (all P < 0.05); vessel wall integrity as assessed by VE-cadherin antibody staining was also improved (P < 0.01). In humans, as assessed by OCTA, increases in PD in the optic nerve head and macula complete image (0.7%, P = 0.04 and 1.0%, P = 0.002, respectively) in healthy controls, and an increase in the temporal quadrant of the macula (0.7%, P = 0.02) in glaucoma patients was seen after NAM treatment.

CONCLUSIONS. NAM can prevent retinal vascular damage in an animal model of glaucoma. After NAM treatment, glaucoma patients and healthy controls demonstrated a small increase in retinal vessel parameters as assessed by OCTA.

sted, utgiver, år, opplag, sider
Association for Research in Vision and Ophthalmology (ARVO), 2023
Emneord
glaucoma, histopathology, nicotinamide, optical coherence tomography angiography, retinal vasculature
HSV kategori
Identifikatorer
urn:nbn:se:umu:diva-218131 (URN)10.1167/iovs.64.14.34 (DOI)38010699 (PubMedID)2-s2.0-85178055569 (Scopus ID)
Forskningsfinansiär
Swedish Research CouncilKarolinska Institute
Tilgjengelig fra: 2023-12-15 Laget: 2023-12-15 Sist oppdatert: 2024-07-02bibliografisk kontrollert
Prosjekter
Neuroprotektiv behandling av glaukom - En klinisk randomiserad studie för utvärdering av nikotinamid [2019-06076_VR]; Umeå universitet
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0003-0218-4563