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Eliasson, Mats
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Lieber, I., Ott, M., Öhlund, L., Lundqvist, R., Eliasson, M., Sandlund, M. & Werneke, U. (2019). Lithium-associated hypothyroidism and potential for reversibility after lithium discontinuation: Findings from the LiSIE retrospective cohort study. Journal of Psychopharmacology, Article ID UNSP 0269881119882858.
Öppna denna publikation i ny flik eller fönster >>Lithium-associated hypothyroidism and potential for reversibility after lithium discontinuation: Findings from the LiSIE retrospective cohort study
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2019 (Engelska)Ingår i: Journal of Psychopharmacology, ISSN 0269-8811, E-ISSN 1461-7285, artikel-id UNSP 0269881119882858Artikel i tidskrift (Refereegranskat) Epub ahead of print
Abstract [en]

Background: The association between lithium and thyroid dysfunction has long been known. However, it remains unknown if lithium-associated hypothyroidism is reversible once lithium treatment has been stopped.

Aims: To determine whether lithium-associated hypothyroidism was reversible in patients who subsequently discontinued lithium.

Methods: A retrospective cohort study in the Swedish region of Norrbotten into the effects and side- effects of lithium treatment and other drugs for relapse prevention (Lithium – Study into Effects and Side Effects). For this particular study, we reviewed medical records between 1997 and 2015 of patients with lithium-associated hypothyroidism who had discontinued lithium.

Results: Of 1340 patients screened, 90 were included. Of these, 27% had overt hypothyroidism at the start of thyroid replacement therapy. The mean delay from starting lithium to starting thyroid replacement therapy was 2.3 years (SD 4.7). In total, 50% of patients received thyroid replacement therapy within 10 months of starting lithium. Of 85 patients available for follow-up, 41% stopped thyroid replacement therapy after lithium discontinuation. Only six patients reinstated thyroid replacement therapy subsequently. Of these, only one had overt hypothyroidism.

Conclusions: Lithium-associated hypothyroidism seems reversible in most patients once lithium has been discontinued. In such cases, thyroid replacement therapy discontinuation could be attempted much more often than currently done. Based on the limited evidence of our study, we can expect hypothyroidism to recur early after thyroid replacement therapy discontinuation, if at all.

Ort, förlag, år, upplaga, sidor
Sage Publications, 2019
Nyckelord
Bipolar disorder, lithium, hypothyroidism, thyroxine, adverse effect
Nationell ämneskategori
Farmakologi och toxikologi
Identifikatorer
urn:nbn:se:umu:diva-165328 (URN)10.1177/0269881119882858 (DOI)000495170900001 ()31670617 (PubMedID)
Forskningsfinansiär
Region NorrbottenAstraZeneca
Tillgänglig från: 2019-12-02 Skapad: 2019-12-02 Senast uppdaterad: 2019-12-02
Crawford, A. A., Söderberg, S., Kirschbaum, C., Murphy, L., Eliasson, M., Ebrahim, S., . . . Walker, B. R. (2019). Morning plasma cortisol as a cardiovascular risk factor: findings from prospective cohort and Mendelian randomization studies. European Journal of Endocrinology, 181(4), 429-438
Öppna denna publikation i ny flik eller fönster >>Morning plasma cortisol as a cardiovascular risk factor: findings from prospective cohort and Mendelian randomization studies
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2019 (Engelska)Ingår i: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 181, nr 4, s. 429-438Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: The identification of new causal risk factors has the potential to improve cardiovascular disease (CVD) risk prediction and the development of new treatments to reduce CVD deaths. In the general population, we sought to determine whether cortisol is a causal risk factor for CVD and coronary heart disease (CHD).

Design and methods: Three approaches were adopted to investigate the association between cortisol and CVD/CHD. First, we used multivariable regression in two prospective nested case-control studies (total 798 participants, 313 incident CVD/CHD with complete data). Second, a random-effects meta-analysis of these data and previously published prospective associations was performed (total 6680 controls, 696 incident CVD/CHD). Finally, one- and two-sample Mendelian randomization analyses were performed (122,737 CHD cases, 547,261 controls for two-sample analyses).

Results: In the two prospective nested case-control studies, logistic regression adjusting for sex, age, BMI, smoking and time of sampling, demonstrated a positive association between morning plasma cortisol and incident CVD (OR: 1.28 per 1 SD higher cortisol, 95% CI: 1.06-1.54). In the meta-analysis of prospective studies, the equivalent result was OR: 1.18, 95% CI: 1.06-1.31. Results from the two-sample Mendelian randomization were consistent with these positive associations: OR: 1.06, 95% Cl: 0.98-1.15.

Conclusions: All three approaches demonstrated a positive association between morning plasma cortisol and incident CVD. Together, these findings suggest that elevated morning cortisol is a causal risk factor for CVD. The current data suggest strategies targeted at lowering cortisol action should be evaluated for their effects on CVD.

Ort, förlag, år, upplaga, sidor
Bioscientifica, 2019
Nationell ämneskategori
Endokrinologi och diabetes
Identifikatorer
urn:nbn:se:umu:diva-164387 (URN)10.1530/EJE-19-0161 (DOI)000486546800012 ()31325907 (PubMedID)
Tillgänglig från: 2019-11-12 Skapad: 2019-11-12 Senast uppdaterad: 2019-11-12Bibliografiskt granskad
Özgümüs, T., Falhammar, H., Nyström, T., Catrina, S.-B. -., Jörneskog, G., Groop, L., . . . Lyssenko, V. (2019). Reduced oxidative phosphorylation can be protective against complications in patients with long-standing type 1 diabetes. Paper presented at 55th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SEP 16-20, 2019, Barcelona, SPAIN. Diabetologia, 62, S545-S545
Öppna denna publikation i ny flik eller fönster >>Reduced oxidative phosphorylation can be protective against complications in patients with long-standing type 1 diabetes
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2019 (Engelska)Ingår i: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 62, s. S545-S545Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
Springer, 2019
Nationell ämneskategori
Endokrinologi och diabetes
Identifikatorer
urn:nbn:se:umu:diva-164069 (URN)000485303804228 ()
Konferens
55th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SEP 16-20, 2019, Barcelona, SPAIN
Anmärkning

Supplement: 1 

Special Issue: SI 

Meeting Abstract: 1130

Tillgänglig från: 2019-10-14 Skapad: 2019-10-14 Senast uppdaterad: 2019-10-14Bibliografiskt granskad
Keindl, M., Fedotkina, A., du Plessis, E., Jain, R., Bergum, B., Falhammar, H., . . . Lyssenko, V. (2019). sIL-2R plasma levels as a potential marker for progression to vascular complications in patients with type 1 diabetes. Paper presented at 55th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SEP 16-20, 2019, Barcelona, SPAIN. Diabetologia, 62, S36-S36
Öppna denna publikation i ny flik eller fönster >>sIL-2R plasma levels as a potential marker for progression to vascular complications in patients with type 1 diabetes
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2019 (Engelska)Ingår i: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 62, s. S36-S36Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
Springer, 2019
Nationell ämneskategori
Endokrinologi och diabetes
Identifikatorer
urn:nbn:se:umu:diva-164068 (URN)000485303800069 ()
Konferens
55th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SEP 16-20, 2019, Barcelona, SPAIN
Anmärkning

Supplement: 1 

Special Issue: SI 

Meeting Abstract: 68

Tillgänglig från: 2019-10-14 Skapad: 2019-10-14 Senast uppdaterad: 2019-10-14Bibliografiskt granskad
Summerhays, E., Eliasson, M., Lundqvist, R., Söderberg, S., Zeller, T. & Oskarsson, V. (2019). Time trends of vitamin D concentrations in northern Sweden between 1986 and 2014: a population-based cross-sectional study. European Journal of Nutrition
Öppna denna publikation i ny flik eller fönster >>Time trends of vitamin D concentrations in northern Sweden between 1986 and 2014: a population-based cross-sectional study
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2019 (Engelska)Ingår i: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215Artikel i tidskrift (Refereegranskat) Epub ahead of print
Abstract [en]

Purpose Vitamin D, produced through cutaneous photosynthesis or ingested via foods or supplements, has generated considerable research interest due to its potential health effects. However, epidemiological data on the time trends of vitamin D status are sparse, especially from northern Europe. We examined the time trend of vitamin D concentrations in northern Sweden between 1986 and 2014. Methods We used data on 11,129 men and women (aged 25-74 years) from seven population-based surveys (the Northern Sweden MONICA study), recruited between 1986 and 2014. Serum vitamin D (25-hydroxyvitamin D) status was measured using a one-step immunoassay (Abbott Architect). Multivariable linear regression models, adjusted for age, sex, and a number of other variables, were used to estimate the time trend of vitamin D concentrations. Results The mean value of vitamin D in the entire study population was 19.9 ng/mL [standard deviation (SD) 7.9], with lower values in men (19.4 ng/mL; SD 7.5) than in women (20.5 ng/mL; SD 8.2). Using the survey in 1986 as reference category, the multivariable-adjusted mean difference [95% confidence interval (CI)] in ng/mL was 2.7 (2.2, 3.3) in 1990, 3.2 (2.7, 3.7) in 1994, 1.6 (1.0, 2.1) in 1999, - 2.0 (- 2.5, - 1.4) in 2004, 1.0 (0.4, 1.5) in 2009, and 3.1 (2.5, 3.6) in 2014. Conclusion In this large cross-sectional study, we observed no clear upward or downward trend of vitamin D concentrations in northern Sweden between 1986 and 2014.

Nyckelord
Vitamin D, Trend, Cross-sectional study, MONICA, Sweden
Nationell ämneskategori
Näringslära
Identifikatorer
urn:nbn:se:umu:diva-166576 (URN)10.1007/s00394-019-02142-x (DOI)000497816400001 ()31754783 (PubMedID)
Tillgänglig från: 2019-12-19 Skapad: 2019-12-19 Senast uppdaterad: 2019-12-19
Eliasson, M., Eriksson, M., Lundqvist, R., Wennberg, P. & Söderberg, S. (2018). Comparison of trends in cardiovascular risk factors between two regions with and without a community and primary care prevention programme. Paper presented at European-Society-of-Cardiology Congress, AUG 25-29, 2018, Munich, GERMANY. European Heart Journal, 39, 76-76
Öppna denna publikation i ny flik eller fönster >>Comparison of trends in cardiovascular risk factors between two regions with and without a community and primary care prevention programme
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2018 (Engelska)Ingår i: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 39, s. 76-76Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
Oxford University Press, 2018
Nationell ämneskategori
Kardiologi Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-157619 (URN)10.1093/eurheartj/ehy564.P608 (DOI)000459824000219 ()
Konferens
European-Society-of-Cardiology Congress, AUG 25-29, 2018, Munich, GERMANY
Anmärkning

Supplement: 1

Meeting Abstract: P608

Tillgänglig från: 2019-03-26 Skapad: 2019-03-26 Senast uppdaterad: 2019-03-26Bibliografiskt granskad
Eliasson, M., Eriksson, M., Lundqvist, R., Wennberg, P. & Söderberg, S. (2018). Comparison of trends in cardiovascular risk factors between two regions with and without a community and primary care prevention programme. European Journal of Preventive Cardiology, 25(6), 1765-1772
Öppna denna publikation i ny flik eller fönster >>Comparison of trends in cardiovascular risk factors between two regions with and without a community and primary care prevention programme
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2018 (Engelska)Ingår i: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 25, nr 6, s. 1765-1772Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background The effect of primary prevention of cardiovascular disease is debated. The Västerbotten Intervention Programme (VIP) is an individual and community-based public health programme that comprises the whole county of Västerbotten (VB). In the neighbouring county of Norrbotten (NB), no programmes have been implemented.

Method Between 1994 and 2014, five surveys were performed in the two counties on persons aged 40 to 75 years within the Northern Sweden MONICA Study. The number of subjects participating was 6600 (75.4%). We compared time trends in risk factors between the two counties using regression models including age, county and year of survey. To test whether time trends differed between counties, the interaction between county and year was included in the models.

Results Systolic blood pressure declined in both counties, and the decline was faster in Västerbotten than in Norrbotten ( p = 0.043 for interaction county*year). Diastolic blood pressure declined in VB but increased in NB ( p < 0.001). Cholesterol levels declined at a similar rate in both counties whereas body mass index increased in both counties. Fasting glucose decreased in VB ( p = 0.003) and increased in NB. The prevalence of regular smokers decreased faster in VB than in NB ( p = 0.01). Trend in waist and hip circumference, known diabetes, having an academic degree, being physically inactive or 10 year cardiovascular mortality according to SCORE did not differ.

Conclusion Blood pressure, glucose and smoking improved at a faster rate in the county with a community and primary care-based intervention than in the county without such an intervention.

Ort, förlag, år, upplaga, sidor
London: Sage Publications, 2018
Nyckelord
Prevention, blood pressure, cardiovascular disease, cholesterol, cohort, diabetes, glucose, obesity, risk factor, smoking
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Kardiologi
Identifikatorer
urn:nbn:se:umu:diva-149620 (URN)10.1177/2047487318778349 (DOI)000448077100013 ()29846119 (PubMedID)
Tillgänglig från: 2018-06-25 Skapad: 2018-06-25 Senast uppdaterad: 2019-05-23Bibliografiskt granskad
Karjalainen, T., Adiels, M., Björck, L., Cooney, M.-T., Graham, I., Perk, J., . . . Eliasson, M. (2017). An evaluation of the performance of SCORE Sweden 2015 in estimating cardiovascular risk: The Northern Sweden MONICA Study 1999-2014. European Journal of Preventive Cardiology, 24(1), 103-110
Öppna denna publikation i ny flik eller fönster >>An evaluation of the performance of SCORE Sweden 2015 in estimating cardiovascular risk: The Northern Sweden MONICA Study 1999-2014
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2017 (Engelska)Ingår i: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 24, nr 1, s. 103-110Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Risk prediction models for cardiovascular death are important for providing advice on lifestyle and in decision-making regarding primary preventive drug treatment. The latest Swedish version of the Systematic COronary Risk Evaluation (SCORE 2015) has yet not been tested in the population.

OBJECTIVE: The objective of this study was to estimate the prevalence of high and very high risk of fatal cardiovascular disease (CVD) of the current population according to 2015 SCORE Sweden and to evaluate the predictive accuracy of the 2003 Swedish version of SCORE (2003 SCORE Sweden) and 2015 SCORE Sweden in a population with declining CVD mortality.

METHODS: We estimated the high and very high risk group for cardiovascular death for individuals 40-65 years of age in the 2014 Northern Sweden MONICA population survey excluding subjects with known diabetes or previous CVD (n = 813). Using the 1999 MONICA survey (n = 3347) followed up for 10 years for CVD mortality, we assessed the calibration of both 2003 and 2015 SCORE Sweden.

RESULTS: In 2014 2.6% of the population was considered at high or very high risk for fatal CVD, 95% were men and 76% were in the age group 60-65 years. Including subjects with a single markedly elevated risk factor, known diabetes or CVD, 12% of the population was at high or very high risk. During 10 years of follow-up of the 1999 cohort, 34 CVD deaths (24 men and 10 women) occurred. The 2003 SCORE overestimated the risk of death from CVD (ratio predicted/observed 2.3, P < 0.001) whereas the 2015 SCORE slightly overestimated the number of deaths (predicted/observed 1.3, P = 0.12). The 2015 SCORE predicted more accurately than the 2003 SCORE the number of deaths in the different risk and age categories.

CONCLUSION: The 2015 SCORE Sweden more adequately than 2003 SCORE Sweden predicts the number of deaths. In 2014, the proportion of high-risk individuals is small in northern Sweden. The main use of 2015 SCORE Sweden would therefore be as an educational tool between the physician and people without diabetes or CVD in a consultation regarding cardiovascular risk.

Nyckelord
Cardiovascular disease, cohort study, mortality, SCORE prediction
Nationell ämneskategori
Klinisk medicin
Identifikatorer
urn:nbn:se:umu:diva-127027 (URN)10.1177/2047487316673142 (DOI)000390556800009 ()27708071 (PubMedID)
Tillgänglig från: 2016-10-26 Skapad: 2016-10-26 Senast uppdaterad: 2018-06-09Bibliografiskt granskad
Brunström, M., Eliasson, M., Nilsson, P. M. & Carlberg, B. (2017). Blood pressure treatment levels and choice of antihypertensive agent in people with diabetes mellitus: an overview of systematic reviews. Journal of Hypertension, 35, 435-462
Öppna denna publikation i ny flik eller fönster >>Blood pressure treatment levels and choice of antihypertensive agent in people with diabetes mellitus: an overview of systematic reviews
2017 (Engelska)Ingår i: Journal of Hypertension, ISSN 0263-6352, E-ISSN 1473-5598, Vol. 35, s. 435-462Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

OBJECTIVE: Multiple systematic reviews address the effect of antihypertensive treatment in people with diabetes. Here, we summarize current systematic reviews concerning antihypertensive treatment effect at different blood pressure (BP) levels, and relative treatment effect of different antihypertensive agents.

METHODS: We searched MEDLINE, BIOSIS, DARE and CDSR during years 2005-2016. Eligibility criteria, number of trials and participants, outcomes analysed, statistical methods used for data synthesis, and principal results were extracted for each review. Review quality was assessed using the assessment of multiple systematic reviews tool.

RESULTS: We found four reviews concerning BP treatment level. These consistently showed that the effect of antihypertensive treatment on mortality, cardiovascular disease and coronary heart disease was attenuated at lower BP levels. If SBP was more than 140 mmHg, treatment reduced all-cause and cardiovascular mortality, cardiovascular disease, stroke, myocardial infarction and heart failure. If SBP was less than 140 mmHg, treatment increased the risk of cardiovascular death. We found eight reviews concerning choice of agent. We found no difference between angiotensin-converting enzyme inhibitors, angotensin receptor blockers, beta-blockers, calcium channel blockers and diuretics in preventing all-cause or cardiovascular mortality, combined cardiovascular disease, coronary heart disease and end-stage renal disease. Minor differences exist for stroke and heart failure. Data were limited on people with type 1 diabetes and very elderly patients with type 2 diabetes. None of the reviews concerning choice of agent included all relevant trials.

CONCLUSION: The available evidence supports treatment in people with type 2 diabetes and SBP more than 140 mmHg, using any of the major antihypertensive drug classes.

Nyckelord
Quality improvement, Stroke registries, Stroke risk factors, Time trends
Nationell ämneskategori
Endokrinologi och diabetes
Identifikatorer
urn:nbn:se:umu:diva-128528 (URN)10.1097/HJH.0000000000001183 (DOI)000393822200004 ()27870655 (PubMedID)
Tillgänglig från: 2016-12-06 Skapad: 2016-12-06 Senast uppdaterad: 2018-06-09Bibliografiskt granskad
Lee, C. M., Woodward, M., Pandeya, N., Adams, R., Barrett-Connor, E., Boyko, E. J., . . . Huxley, R. R. (2017). Comparison of relationships between four common anthropometric measures and incident diabetes. Diabetes Research and Clinical Practice, 132, 36-44
Öppna denna publikation i ny flik eller fönster >>Comparison of relationships between four common anthropometric measures and incident diabetes
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2017 (Engelska)Ingår i: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 132, s. 36-44Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aims: First, to conduct a detailed exploration of the prospective relations between four commonly used anthropometric measures with incident diabetes and to examine their consistency across different population subgroups. Second, to compare the ability of each of the measures to predict five-year risk of diabetes. Methods: We conducted a meta- analysis of individual participant data on body mass index (BMI), waist circumference (WC), waist- hip and waist- height ratio (WHtR) from the Obesity, Diabetes and Cardiovascular Disease Collaboration. Cox proportional hazard models were used to estimate the association between a one standard deviation increment in each anthropometric measure and incident diabetes. Harrell's concordance statistic was used to test the predictive accuracy of each measure for diabetes risk at five years. Results: Twenty- one studies with 154,998 participants and 9342 cases of incident diabetes were available. Each of the measures had a positive association with incident diabetes. A one standard deviation increment in each of the measures was associated with 64- 80% higher diabetes risk. WC and WHtR more strongly associated with risk than BMI (ratio of hazard ratios: 0.95 [0.92,0.99] - 0.97 [0.95,0.98]) but there was no appreciable difference between the four measures in the predictive accuracy for diabetes at five years. Conclusions: Despite suggestions that abdominal measures of obesity have stronger associations with incident diabetes and better predictive accuracy than BMI, we found no overall advantage in any one measure at discriminating the risk of developing diabetes. Any of these measures would suffice to assist in primary diabetes prevention efforts.

Ort, förlag, år, upplaga, sidor
Elsevier, 2017
Nyckelord
Diabetes, Body mass index, Waist circumference
Nationell ämneskategori
Endokrinologi och diabetes
Identifikatorer
urn:nbn:se:umu:diva-142476 (URN)10.1016/j.diabres.2017.07.022 (DOI)000415202800005 ()28783531 (PubMedID)
Tillgänglig från: 2017-12-04 Skapad: 2017-12-04 Senast uppdaterad: 2018-06-09Bibliografiskt granskad
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