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Gouveia-Figueira, S. C., Karimpour, M., Bosson, J. A., Blomberg, A., Unosson, J., Sehlstedt, M., . . . Nording, M. L. (2018). Mass spectrometry profiling reveals altered plasma levels of monohydroxy fatty acids and related lipids in healthy humans after controlled exposure to biodiesel exhaust. Analytica Chimica Acta, 1018, 62-69
Öppna denna publikation i ny flik eller fönster >>Mass spectrometry profiling reveals altered plasma levels of monohydroxy fatty acids and related lipids in healthy humans after controlled exposure to biodiesel exhaust
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2018 (Engelska)Ingår i: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 1018, s. 62-69Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Experimental human exposure studies are an effective tool to study adverse health effects from acute inhalation of particulate matter and other constituents of air pollution. In this randomized and double-blinded crossover study, we investigated the systemic effect on bioactive lipid metabolite levels after controlled biodiesel exhaust exposure of healthy humans and compared it to filtered air at a separate exposure occasion. Eicosanoids and other oxylipins, as well as endocannabinoids and related lipids, were quantified in plasma from 14 healthy volunteers at baseline and at three subsequent time points (2, 6, and 24 h) after 1 h exposure sessions. Protocols based on liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS) methods were developed to detect temporal changes in circulating levels after biodiesel exhaust exposure. The exhaust was generated by a diesel engine fed with an undiluted rapeseed methyl ester fuel. Among the 51 analyzed lipid metabolites, PGF(2 alpha), 9,10-DiHOME, 9-HODE, 5-HETE, 11-HETE, 12-HETE, and DEA displayed significant responsiveness to the biodiesel exhaust exposure as opposed to filtered air. Of these, 9-HODE and 5-HETE at 24 h survived the 10% false discovery rate cutoff (p < 0.003). Hence, the majority of the responsive lipid metabolites were monohydroxy fatty acids. We conclude that it is possible to detect alterations in circulating bioactive lipid metabolites in response to biodiesel exhaust exposure using LC-MS/MS, with emphasis on metabolites with inflammation related properties and implications on cardiovascular health and disease. These observations aid future investigations on air pollution effects, especially with regard to cardiovascular outcomes.

Ort, förlag, år, upplaga, sidor
Elsevier, 2018
Nyckelord
Oxylipin, Endocannabinoid, Eicosanoid, Mass spectrometry, Rapeseed methyl ester, Inflammation
Nationell ämneskategori
Arbetsmedicin och miljömedicin Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-148622 (URN)10.1016/j.aca.2018.02.032 (DOI)000428798200008 ()29605135 (PubMedID)
Forskningsfinansiär
Vetenskapsrådet, 2010-303AFA Försäkring, 130320
Tillgänglig från: 2018-06-26 Skapad: 2018-06-26 Senast uppdaterad: 2018-06-26Bibliografiskt granskad
Gouveia-Figueira, S., Karimpour, M., Bosson, J. A., Blomberg, A., Unosson, J., Pourazar, J., . . . Nording, M. L. (2017). Mass spectrometry profiling of oxylipins, endocannabinoids, and N-acylethanolamines in human lung lavage fluids reveals responsiveness of prostaglandin E2 and associated lipid metabolites to biodiesel exhaust exposure. Analytical and Bioanalytical Chemistry, 409(11), 2967-2980
Öppna denna publikation i ny flik eller fönster >>Mass spectrometry profiling of oxylipins, endocannabinoids, and N-acylethanolamines in human lung lavage fluids reveals responsiveness of prostaglandin E2 and associated lipid metabolites to biodiesel exhaust exposure
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2017 (Engelska)Ingår i: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 409, nr 11, s. 2967-2980Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The adverse effects of petrodiesel exhaust exposure on the cardiovascular and respiratory systems are well recognized. While biofuels such as rapeseed methyl ester (RME) biodiesel may have ecological advantages, the exhaust generated may cause adverse health effects. In the current study, we investigated the responses of bioactive lipid mediators in human airways after biodiesel exhaust exposure using lipidomic profiling methods. Lipid mediator levels in lung lavage were assessed following 1-h biodiesel exhaust (average particulate matter concentration, 159 mu g/m(3)) or filtered air exposure in 15 healthy individuals in a double-blinded, randomized, controlled, crossover study design. Bronchoscopy was performed 6 h post exposure and lung lavage fluids, i.e., bronchial wash (BW) and bronchoalveolar lavage (BAL), were sequentially collected. Mass spectrometry methods were used to detect a wide array of oxylipins (including eicosanoids), endocannabinoids, Nacylethanolamines, and related lipid metabolites in the collected BWand BAL samples. Six lipids in the human lung lavage samples were altered following biodiesel exhaust exposure, three from BAL samples and three from BW samples. Of these, elevated levels of PGE2, 12,13-DiHOME, and 13-HODE, all of which were found in BAL samples, reached Bonferroni-corrected significance. This is the first study in humans reporting responses of bioactive lipids following biodiesel exhaust exposure and the most pronounced responses were seen in the more peripheral and alveolar lung compartments, reflected by BAL collection. Since the responsiveness and diagnostic value of a subset of the studied lipid metabolites were established in lavage fluids, we conclude that our mass spectrometry profiling method is useful to assess effects of human exposure to vehicle exhaust.

Ort, förlag, år, upplaga, sidor
SPRINGER HEIDELBERG, 2017
Nyckelord
BAL, BW, Lipidome, Air pollution, Bronchoscopy, Eicosanoid
Nationell ämneskategori
Arbetsmedicin och miljömedicin
Identifikatorer
urn:nbn:se:umu:diva-134210 (URN)10.1007/s00216-017-0243-8 (DOI)000398515900019 ()28235994 (PubMedID)
Tillgänglig från: 2017-06-20 Skapad: 2017-06-20 Senast uppdaterad: 2018-06-09Bibliografiskt granskad
Pourazar, J., Rankin, G. D., Muala, A., Unosson, J., Sehlstedt, M., Behndig, A. F., . . . Sandstrom, T. (2016). Bronchoalveolar Eosinophilia In Human Subjects After Exposure To Biomass Smoke From Wood Pellet Combustion. In: : . Paper presented at International Conference of the American-Thoracic-Society (ATS), MAY 13-18, 2016, San Francisco, CA. , 193
Öppna denna publikation i ny flik eller fönster >>Bronchoalveolar Eosinophilia In Human Subjects After Exposure To Biomass Smoke From Wood Pellet Combustion
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2016 (Engelska)Konferensbidrag, Muntlig presentation med publicerat abstract (Refereegranskat)
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-131011 (URN)000390749607595 ()
Konferens
International Conference of the American-Thoracic-Society (ATS), MAY 13-18, 2016, San Francisco, CA
Tillgänglig från: 2017-02-09 Skapad: 2017-02-09 Senast uppdaterad: 2018-06-09Bibliografiskt granskad
Surowiec, I., Karimpour, M., Gouveia-Figueira, S., Wu, J., Unosson, J., Bosson, J. A., . . . Nording, M. L. (2016). Multi-platform metabolomics assays for human lung lavage fluids in an air pollution exposure study. Analytical and Bioanalytical Chemistry, 408(17), 4751-4764
Öppna denna publikation i ny flik eller fönster >>Multi-platform metabolomics assays for human lung lavage fluids in an air pollution exposure study
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2016 (Engelska)Ingår i: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 408, nr 17, s. 4751-4764Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Metabolomics protocols are used to comprehensively characterize the metabolite content of biological samples by exploiting cutting-edge analytical platforms, such as gas chromatography (GC) or liquid chromatography (LC) coupled to mass spectrometry (MS) assays, as well as nuclear magnetic resonance (NMR) assays. We have developed novel sample preparation procedures combined with GC-MS, LC-MS, and NMR metabolomics profiling for analyzing bronchial wash (BW) and bronchoalveolar lavage (BAL) fluid from 15 healthy volunteers following exposure to biodiesel exhaust and filtered air. Our aim was to investigate the responsiveness of metabolite profiles in the human lung to air pollution exposure derived from combustion of biofuels, such as rapeseed methyl ester biodiesel, which are increasingly being promoted as alternatives to conventional fossil fuels. Our multi-platform approach enabled us to detect the greatest number of unique metabolites yet reported in BW and BAL fluid (82 in total). All of the metabolomics assays indicated that the metabolite profiles of the BW and BAL fluids differed appreciably, with 46 metabolites showing significantly different levels in the corresponding lung compartments. Furthermore, the GC-MS assay revealed an effect of biodiesel exhaust exposure on the levels of 1-monostearylglycerol, sucrose, inosine, nonanoic acid, and ethanolamine (in BAL) and pentadecanoic acid (in BW), whereas the LC-MS assay indicated a shift in the levels of niacinamide (in BAL). The NMR assay only identified lactic acid (in BW) as being responsive to biodiesel exhaust exposure. Our findings demonstrate that the proposed multi-platform approach is useful for wide metabolomics screening of BW and BAL fluids and can facilitate elucidation of metabolites responsive to biodiesel exhaust exposure.

Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-121129 (URN)10.1007/s00216-016-9566-0 (DOI)000378725200024 ()
Tillgänglig från: 2016-05-26 Skapad: 2016-05-26 Senast uppdaterad: 2018-06-07Bibliografiskt granskad
Langrish, J. P., Unosson, J., Pourazar, J., Stannett, C., Mills, N. L., Newby, D. E., . . . Bosson, J. (2016). The use of a highly-efficient facemask to protect against the acute cardiovascular effects of dilute diesel exhaust exposure. Paper presented at Congress of the European-Society-of-Cardiology (ESC), AUG 27-31, 2016, Rome, ITALY. European Heart Journal, 37, 550-551
Öppna denna publikation i ny flik eller fönster >>The use of a highly-efficient facemask to protect against the acute cardiovascular effects of dilute diesel exhaust exposure
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2016 (Engelska)Ingår i: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 37, s. 550-551Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
Oxford University Press, 2016
Nationell ämneskategori
Kardiologi
Identifikatorer
urn:nbn:se:umu:diva-129755 (URN)000383869502498 ()
Konferens
Congress of the European-Society-of-Cardiology (ESC), AUG 27-31, 2016, Rome, ITALY
Anmärkning

Supplement: 1

Meeting Abstract: P2731

Tillgänglig från: 2017-01-10 Skapad: 2017-01-09 Senast uppdaterad: 2018-06-09Bibliografiskt granskad
Muala, A., Rankin, G., Sehlstedt, M., Unosson, J., Bosson, J. A., Behndig, A., . . . Sandström, T. (2015). Acute exposure to wood smoke from incomplete combustion - indications of cytotoxicity. Particle and Fibre Toxicology, 12, Article ID 33.
Öppna denna publikation i ny flik eller fönster >>Acute exposure to wood smoke from incomplete combustion - indications of cytotoxicity
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2015 (Engelska)Ingår i: Particle and Fibre Toxicology, ISSN 1743-8977, E-ISSN 1743-8977, Vol. 12, artikel-id 33Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Smoke from combustion of biomass fuels is a major risk factor for respiratory disease, but the underlying mechanisms are poorly understood. The aim of this study was to determine whether exposure to wood smoke from incomplete combustion would elicit airway inflammation in humans. Methods: Fourteen healthy subjects underwent controlled exposures on two separate occasions to filtered air and wood smoke from incomplete combustion with PM1 concentration at 314 mu g/m(3) for 3 h in a chamber. Bronchoscopy with bronchial wash (BW), bronchoalveolar lavage (BAL) and endobronchial mucosal biopsies was performed after 24 h. Differential cell counts and soluble components were analyzed, with biopsies stained for inflammatory markers using immunohistochemistry. In parallel experiments, the toxicity of the particulate matter (PM) generated during the chamber exposures was investigated in vitro using the RAW264.7 macrophage cell line. Results: Significant reductions in macrophage, neutrophil and lymphocyte numbers were observed in BW (p < 0.01, < 0.05, < 0.05, respectively) following the wood smoke exposure, with a reduction in lymphocytes numbers in BAL fluid (< 0.01. This unexpected cellular response was accompanied by decreased levels of sICAM-1, MPO and MMP-9 (p < 0.05, < 0.05 and < 0.01). In contrast, significant increases in submucosal and epithelial CD3+ cells, epithelial CD8+ cells and submucosal mast cells (p < 0.01, < 0.05, < 0.05 and < 0.05, respectively), were observed after wood smoke exposure. The in vitro data demonstrated that wood smoke particles generated under these incomplete combustion conditions induced cell death and DNA damage, with only minor inflammatory responses. Conclusions: Short-term exposure to sooty PAH rich wood smoke did not induce an acute neutrophilic inflammation, a classic hallmark of air pollution exposure in humans. While minor proinflammatory lymphocytic and mast cells effects were observed in the bronchial biopsies, significant reductions in BW and BAL cells and soluble components were noted. This unexpected observation, combined with the in vitro data, suggests that wood smoke particles from incomplete combustion could be potentially cytotoxic. Additional research is required to establish the mechanism of this dramatic reduction in airway leukocytes and to clarify how this acute response contributes to the adverse health effects attributed to wood smoke exposure.

Nyckelord
Air pollution, Biomass, Bronchoscopy, Cytotoxicity, Neutrophils, Lymphocytes, Mast cells
Nationell ämneskategori
Miljövetenskap
Identifikatorer
urn:nbn:se:umu:diva-111761 (URN)10.1186/s12989-015-0111-7 (DOI)000363833500001 ()26511835 (PubMedID)2-s2.0-84945908415 (Scopus ID)
Tillgänglig från: 2015-11-25 Skapad: 2015-11-23 Senast uppdaterad: 2018-06-07Bibliografiskt granskad
Pourazar, J., Behndig, A. F., Helleday, R., Muala, A., Rankin, G., Sehlstedt, M., . . . Bosson, J. A. (2015). Airway Inflammatory Response In Healthy Subjects Following Chamber Exposure To 100% Rme Biodiesel. Paper presented at International Conference of the American-Thoracic-Society (ATS), MAY 15-20, 2015, Denver, CO. American Journal of Respiratory and Critical Care Medicine, 191, Article ID A5252.
Öppna denna publikation i ny flik eller fönster >>Airway Inflammatory Response In Healthy Subjects Following Chamber Exposure To 100% Rme Biodiesel
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2015 (Engelska)Ingår i: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 191, artikel-id A5252Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-123483 (URN)000377582807072 ()
Konferens
International Conference of the American-Thoracic-Society (ATS), MAY 15-20, 2015, Denver, CO
Tillgänglig från: 2016-07-06 Skapad: 2016-07-04 Senast uppdaterad: 2018-06-07Bibliografiskt granskad
Gouveia-Figueira, S., Bosson, J. A., Unosson, J., Behndig, A. F., Nording, M. & Fowler, C. (2015). Relative and absolute reliability of measures of linoleic acid-derived oxylipins in human plasma. Prostaglandins & other lipid mediators, 121(Part B), 227-233
Öppna denna publikation i ny flik eller fönster >>Relative and absolute reliability of measures of linoleic acid-derived oxylipins in human plasma
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2015 (Engelska)Ingår i: Prostaglandins & other lipid mediators, ISSN 1098-8823, E-ISSN 2212-196X, Vol. 121, nr Part B, s. 227-233Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Modern analytical techniques allow for the measurement of oxylipins derived from linoleic acid in biological samples. Most validatory work has concerned extraction techniques, repeated analysis of aliquots from the same biological sample, and the influence of external factors such as diet and heparin treatment upon their levels, whereas less is known about the relative and absolute reliability of measurements undertaken on different days. A cohort of nineteen healthy males were used, where samples were taken at the same time of day on two occasions, at least 7 days apart. Relative reliability was assessed using Lin's concordance correlation coefficients (CCC) and intraclass correlation coefficients (ICC). Absolute reliability was assessed by Bland-Altman analyses. Nine linoleic acid oxylipins were investigated. ICC and CCC values ranged from acceptable (0.56 [13-HODE]) to poor (near zero [9(10)- and 12(13)-EpOME]). Bland-Altman limits of agreement were in general quite wide, ranging from ±0.5 (12,13-DiHOME) to ±2 (9(10)-EpOME; log10 scale). It is concluded that relative reliability of linoleic acid-derived oxylipins varies between lipids with compounds such as the HODEs showing better relative reliability than compounds such as the EpOMEs. These differences should be kept in mind when designing and interpreting experiments correlating plasma levels of these lipids with factors such as age, body mass index, rating scales etc.

Ort, förlag, år, upplaga, sidor
Elsevier, 2015
Nyckelord
Oxylipins, Arachidonic acid, HETE, Linoleic acid, HODE, DiHOME, Repeatability, Reliability, Bland–Altman analyses, Concordance correlation coefficients, Intraclass correlation coefficients, Human plasma
Nationell ämneskategori
Kemi Biokemi och molekylärbiologi Cellbiologi
Identifikatorer
urn:nbn:se:umu:diva-112032 (URN)10.1016/j.prostaglandins.2015.10.003 (DOI)000367636300011 ()26498702 (PubMedID)
Tillgänglig från: 2015-11-30 Skapad: 2015-11-30 Senast uppdaterad: 2018-06-07Bibliografiskt granskad
Unosson, J. (2014). Acute cardiovascular effects of biofuel exhaust exposure. (Doctoral dissertation). Umeå: Umeå Universitet
Öppna denna publikation i ny flik eller fönster >>Acute cardiovascular effects of biofuel exhaust exposure
2014 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Background

Anthropogenic air pollution is a global health problem estimated to contribute to millions of premature deaths. Exposure to biomass smoke is common due to varying sources, such as wildfires, indoor cooking over open fires, and residential heating from wood stoves. In urban environments transportation and industry rely heavily on the combustion of fossil fuels yet environmental policies increasingly support a shift to renewable fuels such as biodiesel. It has not been investigated how either wood smoke or biodiesel exhaust affect human health in general or the cardiovascular system in particular. We hypothesized that wood smoke exposure would induce acute cardiovascular impairment via similar underlying mechanisms as have been established for petrodiesel exhaust exposure. We also hypothesized that replacing petrodiesel with biodiesel, as a blend or pure biodiesel, would generate an exhaust profile with a less harmful effect on the cardiovascular system than petrodiesel exhaust.

Methods

In four separate studies healthy non-smoking subjects were exposed to different air pollutants in controlled exposure chambers followed by clinical investigations of the cardiovascular system. All studies were performed as randomized controlled trials in a crossover fashion with each individual acting as her own control. In study I healthy volunteers were exposed to wood smoke at a target concentration of particulate matter (PM) 300 µg/mfor three hours followed by measures of blood pressure, heart rate variability and central arterial stiffness. In study II subjects were exposed to wood smoke at a target concentration of PM 1000 µg/mfor one hour followed by measures of thrombus formation using the Badimon technique and vasomotor function using forearm venous occlusion plethysmography. In study III subjects were exposed to petrodiesel exhaust and a 30% rapeseed methyl ester (RME30) biodiesel blend for one hour at a target concentration of PM 300 µg/m3. Following exposure, thrombus formation and vasomotor function were assessed as in study II. In study IV subjects were exposed to petrodiesel exhaust at a target concentration of PM 300 μg/m3for one hour and pure rapeseed methyl ester (RME100) exhaust generated at identical running conditions of the engine. Following exposure, thrombus formation and vasomotor function were assessed as in study II and III.

Results

In study I fourteen subjects (8 males) were exposed to wood smoke at P M 294±36 μg/m3. Compared to filtered air exposure, measures of central arterial stiffness were increased and heart rate variability was decreased following wood smoke exposure. No effect was seen on blood pressure. In study II sixteen males were exposed to wood smoke at PM 899±100 μg/m3. We found no evidence of increased thrombus formation or impaired vasomotor function following wood smoke exposure. In study III sixteen subjects (14 males) were exposed to petrodiesel exhaust (PM 314±27 µg/m3) and RME30 exhaust (PM 309±30 µg/m3). Thrombus formation and vasomotor function were equal following either exposure. In study IV nineteen males were exposed to petrodiesel exhaust (PM 310±34 µg/m3, 1.7±0.3 x105 particles/cm3) and RME100 exhaust (PM 165±16 µg/m3, 2.2±0.1 x10particles/cm3). As in study III, thrombus formation and vasomotor function were identical following both exposures.

Conclusions

We have for the first time demonstrated that wood smoke exposure can increase central arterial stiffness and decrease heart rate variability in healthy subjects. We did not, however find evidence of increased thrombus formation and impaired vasomotor function following wood smoke exposure at a higher concentration for a shorter time period. We have, for the first time, demonstrated that exhaust from RME biodiesel induced acute adverse cardiovascular effects of increased thrombus formation and impaired vasomotor function in man. These effects are on par with those seen following exposure to petrodiesel exhaust, despite marked physicochemical differences of the exhaust characteristics.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå Universitet, 2014. s. 96
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 1690
Nyckelord
Cardiovascular, air pollution, endothelial dyssfunction, arterial stiffness, wood smoke, woodsmoke, biodiesel, RME, biofuel, diesel exhaust
Nationell ämneskategori
Kardiologi
Identifikatorer
urn:nbn:se:umu:diva-96449 (URN)978-91-7601-175-1 (ISBN)
Disputation
2014-12-12, Sal D, 9 trappor, byggnad 1D, Norrlands Universitetssjukhus, Universitetssjukhuset, Umeå, 12:56 (Engelska)
Opponent
Handledare
Forskningsfinansiär
Hjärt-LungfondenAFA Försäkring
Tillgänglig från: 2014-11-21 Skapad: 2014-11-20 Senast uppdaterad: 2018-06-07Bibliografiskt granskad
Langrish, J. P., Watts, S. J., Hunter, A. J., Shah, A. S. V., Bosson, J. A., Unosson, J., . . . Mills, N. L. (2014). Controlled exposures to air pollutants and risk of cardiac arrhythmia. Journal of Environmental Health Perspectives, 122(7), 747-753
Öppna denna publikation i ny flik eller fönster >>Controlled exposures to air pollutants and risk of cardiac arrhythmia
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2014 (Engelska)Ingår i: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 122, nr 7, s. 747-753Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Epidemiological studies have reported associations between air pollution exposure and increases in cardiovascular morbidity and mortality. Exposure to air pollutants can influence cardiac autonomic tone and reduce heart rate variability, and may increase the risk of cardiac arrhythmias, particularly in susceptible patient groups. OBJECTIVES: We investigated the incidence of cardiac arrhythmias during and after controlled exposure to air pollutants in healthy volunteers and patients with coronary heart disease. METHODS: We analyzed data from 13 double-blind randomized crossover studies including 282 participants (140 healthy volunteers and 142 patients with stable coronary heart disease) from whom continuous electrocardiograms were available. The incidence of cardiac arrhythmias was recorded for each exposure and study population. RESULTS: There were no increases in any cardiac arrhythmia during or after exposure to dilute diesel exhaust, wood smoke, ozone, concentrated ambient particles, engineered carbon nanoparticles, or high ambient levels of air pollution in either healthy volunteers or patients with coronary heart disease. CONCLUSIONS: Acute controlled exposure to air pollutants did not increase the short-term risk of arrhythmia in participants. Research employing these techniques remains crucial in identifying the important pathophysiological pathways involved in the adverse effects of air pollution, and is vital to inform environmental and public health policy decisions.

Nationell ämneskategori
Arbetsmedicin och miljömedicin Farmakologi och toxikologi Miljövetenskap
Identifikatorer
urn:nbn:se:umu:diva-91845 (URN)10.1289/ehp.1307337 (DOI)000338928000026 ()
Tillgänglig från: 2014-08-27 Skapad: 2014-08-18 Senast uppdaterad: 2018-06-07Bibliografiskt granskad
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