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Sandin, Anna
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Al-Tamprouri, C., Barman, M., Hesselmar, B., Bråbäck, L. & Sandin, A. (2019). Cat and dog ownership during/after the first year of life and risk for sensitization and reported allergy symptoms at age 13. Immunity, Inflammation and Disease
Öppna denna publikation i ny flik eller fönster >>Cat and dog ownership during/after the first year of life and risk for sensitization and reported allergy symptoms at age 13
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2019 (Engelska)Ingår i: Immunity, Inflammation and Disease, E-ISSN 2050-4527Artikel i tidskrift (Refereegranskat) Epub ahead of print
Abstract [en]

Background: Avoidance of pets as a strategy for preventing atopic diseases has been questioned. This study aimed to identify the risk of sensitization and allergic symptoms at age 13 in relation to dog‐ and cat‐keeping during and after the first year of life.

Methods: The study included all children born at Östersund Hospital in Northern Sweden between February 1996 and January 1997 (n = 1231). At inclusion, parents were asked to answer questionnaires about lifestyle, including cat‐ and dog‐keeping. Dog allergy, cat allergy, hay fever, and asthma were diagnosed based on parental reported allergic symptoms at 13 years of age (n = 834). The risks of sensitization or allergy in relation to dog‐ and cat‐keeping during and after the first year of life were analyzed with logistic regression. To adjust for reverse causation, all subjects that had reported avoidance of pets due to allergic symptoms of the child or allergy in the family (n = 177) were excluded.

Results: Dog‐ or cat‐keeping during the first year of life reduced the risk of sensitization to dog or cat allergens, respectively, and to birch and to at least one of the 10 allergens tested. Cat‐keeping, both during and after the first year of life, reduced the risk of cat allergy and hay fever. Having a dog at home during the first year of life reduced the risk of dog and cat allergy, whereas dog‐keeping after the first year of life did not affect allergic symptoms.

Conclusions: Cat ownership, either during or after the first year of life, may be a strategy for preventing the development of cat allergy and hay fever later in life. Dog ownership reduced the risk of sensitization to dog and birch allergen, and also the risk of cat and dog allergy, but had no effect on hay fever.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2019
Nyckelord
allergic symptoms, asthma, birth cohort, cat-keeping, dog-keeping, sensitization
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-164646 (URN)10.1002/iid3.267 (DOI)000484624700001 ()31464382 (PubMedID)2-s2.0-85071341963 (Scopus ID)
Tillgänglig från: 2019-11-08 Skapad: 2019-11-08 Senast uppdaterad: 2019-11-08
Stråvik, M., Jonsson, K., Hartvigsson, O., Sandin, A., Wold, A. E., Sandberg, A.-S. & Barman, M. (2019). Food and Nutrient Intake during Pregnancy in Relation to Maternal Characteristics: Results from the NICE Birth Cohort in Northern Sweden. Nutrients, 11(7), Article ID 1680.
Öppna denna publikation i ny flik eller fönster >>Food and Nutrient Intake during Pregnancy in Relation to Maternal Characteristics: Results from the NICE Birth Cohort in Northern Sweden
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2019 (Engelska)Ingår i: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 11, nr 7, artikel-id 1680Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Linkages between diet and other lifestyle factors may confound observational studies. We used cluster analysis to analyze how the intake of food and nutrients during pregnancy co-varies with lifestyle, clinical and demographic factors in 567 women who participated in the NICE (nutritional impact on immunological maturation during childhood in relation to the environment) birth-cohort in northern Sweden. A food frequency questionnaire, Meal-Q, was administered in pregnancy Week 34, and the reported food and nutrient intakes were related to maternal characteristics such as age, education, rural/town residence, parity, pre-pregnancy smoking, first-trimester BMI, allergy and hyperemesis. Two lifestyle-diet clusters were identified: (1) High level of education and higher age were related to one another, and associated with a diet rich in fruits, vegetables, whole grains and fish, and (2) smoking before pregnancy and higher BMI in early pregnancy were related to one another and associated with a diet that contained white bread, French fries, pizza, meat, soft drinks, candy and snacks. More than half of the women had lower-than-recommended daily intake levels of vitamin D, folate, selenium, and iodine. Complex lifestyle-diet interactions should be considered in observational studies that link diet and pregnancy outcome.

Ort, förlag, år, upplaga, sidor
MDPI, 2019
Nyckelord
nutrition, pregnancy, micronutrients, macronutrients, food intake, lifestyle, NICE study
Nationell ämneskategori
Näringslära
Identifikatorer
urn:nbn:se:umu:diva-162682 (URN)10.3390/nu11071680 (DOI)000478885400236 ()31336625 (PubMedID)
Tillgänglig från: 2019-08-29 Skapad: 2019-08-29 Senast uppdaterad: 2019-08-29Bibliografiskt granskad
Barman, M., Murray, F., Bernardi, A. I., Broberg, K., Bölte, S., Hesselmar, B., . . . Sandin, A. (2018). Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden. BMJ Open, 8(10), Article ID e022013.
Öppna denna publikation i ny flik eller fönster >>Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden
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2018 (Engelska)Ingår i: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 8, nr 10, artikel-id e022013Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Introduction Prenatal and neonatal environmental factors, such as nutrition, microbes and toxicants, may affect health throughout life. Many diseases, such as allergy and impaired child development, may be programmed already in utero or during early infancy. Birth cohorts are important tools to study associations between early life exposure and disease risk. Here, we describe the study protocol of the prospective birth cohort, 'Nutritional impact on Immunological maturation during Childhood in relation to the Environment' (NICE). The primary aim of the NICE cohort is to clarify the effect of key environmental exposures-diet, microbes and environmental toxicants-during pregnancy and early childhood, on the maturation of the infant's immune system, including initiation of sensitisation and allergy as well as some secondary outcomes: infant growth, obesity, neurological development and oral health. Methods and analysis The NICE cohort will recruit about 650 families during mid-pregnancy. The principal inclusion criterion will be planned birth at the Sunderby Hospital in the north of Sweden, during 2015-2018. Questionnaires data and biological samples will be collected at 10 time-points, from pregnancy until the children reach 4 years of age. Samples will be collected primarily from mothers and children, and from fathers. Biological samples include blood, urine, placenta, breast milk, meconium, faeces, saliva and hair. Information regarding allergic heredity, diet, socioeconomic status, lifestyle including smoking, siblings, pet ownership, etc will be collected using questionnaires. Sensitisation to common allergens will be assessed by skin prick testing and allergic disease will be diagnosed by a paediatrician at 1 and 4 years of age. At 4 years of age, the children will also be examined regarding growth, neurobehavioural and neurophysiological status and oral health. Ethics and dissemination The NICE cohort has been approved by the Regional Ethical Review Board in Umea, Sweden (2013/18-31M). Results will be disseminated through peer-reviewed journals and communicated on scientific conferences.

Ort, förlag, år, upplaga, sidor
BMJ Publishing Group Ltd, 2018
Nationell ämneskategori
Pediatrik
Identifikatorer
urn:nbn:se:umu:diva-155656 (URN)10.1136/bmjopen-2018-022013 (DOI)000454739500070 ()30344169 (PubMedID)
Tillgänglig från: 2019-01-25 Skapad: 2019-01-25 Senast uppdaterad: 2019-01-25Bibliografiskt granskad
Barman, M., Jonsson, K., Hesselmar, B., Sandin, A., Sandberg, A.-S. & Wold, A. E. (2015). No association between allergy and current 25-hydroxy vitamin D in serum or vitamin D intake. Acta Paediatrica, 104(4), 405-413
Öppna denna publikation i ny flik eller fönster >>No association between allergy and current 25-hydroxy vitamin D in serum or vitamin D intake
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2015 (Engelska)Ingår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, nr 4, s. 405-413Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aim Vitamin D may be involved in allergy development, but there is conflicting evidence. We investigated if dietary intake of vitamin D and levels of 25OHD in serum differed between allergic and nonallergic adolescents and if serum 25OHD correlated with dietary intake of vitamin D or season of blood sampling.

Methods Serum 25-hydroxy vitamin D (25OHD) levels were analysed in 13-year-old subjects with atopic eczema (n=55), respiratory allergy (n=55) or no allergy (n=55). Intake of fat-containing foods was assessed by food-frequency questionnaires, and total daily vitamin D intake was calculated. Logistic regression was used to adjust for gender, parental allergy and time of blood sampling.

Results Subjects with atopic eczema or respiratory allergy did not differ from nonallergic controls regarding serum 25OHD levels or calculated vitamin D intake. Subjects sampled in the autumn had significantly higher levels of serum 25OHD than subjects sampled in the winter or spring. Serum 25OHD levels correlated to consumption of vitamin D-fortified lean milk (p=0.001).

Conclusion The findings suggest no association between allergy and 25OHD levels in serum or vitamin D intake in adolescents. Serum 25OHD levels correlated to intake of vitamin D-fortified lean milk.

Nyckelord
25-hydroxy vitamin D, Allergy, Asthma, Atopic eczema, Vitamin D
Nationell ämneskategori
Pediatrik
Identifikatorer
urn:nbn:se:umu:diva-102352 (URN)10.1111/apa.12936 (DOI)000351744200022 ()25603834 (PubMedID)
Tillgänglig från: 2015-06-02 Skapad: 2015-04-23 Senast uppdaterad: 2018-06-07Bibliografiskt granskad
Barman, M., Nilsson, S., Naluai, T. A., Sandin, A., Wold, A. & Sandberg, A.-S. (2015). Single nucleotide polymorphisms in fatty acid desaturases is associated with cord blood long chain PUFA proportions and development of allergy. Paper presented at Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, JUN 06-10, 2015, Barcelona, SPAIN. Allergy. European Journal of Allergy and Clinical Immunology, 70, 402-402
Öppna denna publikation i ny flik eller fönster >>Single nucleotide polymorphisms in fatty acid desaturases is associated with cord blood long chain PUFA proportions and development of allergy
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2015 (Engelska)Ingår i: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 70, s. 402-402Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-118440 (URN)000369950702303 ()
Konferens
Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, JUN 06-10, 2015, Barcelona, SPAIN
Anmärkning

Special Issue

Tillgänglig från: 2016-03-30 Skapad: 2016-03-18 Senast uppdaterad: 2018-06-07Bibliografiskt granskad
Barman, M., Nilsson, S., Torinsson Naluai, Å., Sandin, A., Wold, A. E. & Sandberg, A.-S. (2015). Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort). Nutrients, 7(12), 10100-10115
Öppna denna publikation i ny flik eller fönster >>Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort)
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2015 (Engelska)Ingår i: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 7, nr 12, s. 10100-10115Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Exposure to polyunsaturated fatty acids (PUFA) influences immune function and may affect the risk of allergy development. Long chain PUFAs are produced from dietary precursors catalyzed by desaturases and elongases encoded by FADS and ELOVL genes. In 211 subjects, we investigated whether polymorphisms in the FADS gene cluster and the ELOVL2 gene were associated with allergy or PUFA composition in serum phospholipids in a Swedish birth-cohort sampled at birth and at 13 years of age; allergy was diagnosed at 13 years of age. Minor allele carriers of rs102275 and rs174448 (FADS gene cluster) had decreased proportions of 20:4 n-6 in cord and adolescent serum and increased proportions of 20:3 n-6 in cord serum as well as a nominally reduced risk of developing atopic eczema, but not respiratory allergy, at 13 years of age. Minor allele carriers of rs17606561 in the ELOVL2 gene had nominally decreased proportions of 20:4 n-6 in cord serum but ELOVL polymorphisms (rs2236212 and rs17606561) were not associated with allergy development. Thus, reduced capacity to desaturase n-6 PUFAs due to FADS polymorphisms was nominally associated with reduced risk for eczema development, which could indicate a pathogenic role for long-chain PUFAs in allergy development.

Ort, förlag, år, upplaga, sidor
MPDI, 2015
Nyckelord
long chain polyunsaturated fatty acids, arachidonic acid, phospholipids, umbilical cord serum, single nucleotide polymorphism, fatty acid desaturase, FADS, elongase, ELOVL2, nutrigenetics, allergy, atopic eczema, respiratory allergy, BAS birth cohort
Nationell ämneskategori
Näringslära
Identifikatorer
urn:nbn:se:umu:diva-114636 (URN)10.3390/nu7125521 (DOI)000367052200028 ()26633493 (PubMedID)
Tillgänglig från: 2016-02-03 Skapad: 2016-01-25 Senast uppdaterad: 2018-06-07Bibliografiskt granskad
Barman, M., Jonsson, K., Sandin, A., Wold, A. E. & Sandberg, A.-S. (2014). Serum fatty acid profile does not reflect seafood intake in adolescents with atopic eczema. Acta Paediatrica, 103(9), 968-976
Öppna denna publikation i ny flik eller fönster >>Serum fatty acid profile does not reflect seafood intake in adolescents with atopic eczema
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2014 (Engelska)Ingår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 103, nr 9, s. 968-976Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aim: Long-chain polyunsaturated fatty acids (LCPUFAs) are immunomodulatory, but their role in allergy development is controversial. We investigated whether proportions of LCPUFAs in serum phospholipids were related to allergic diagnosis, seafood intake and LCPUFA proportions in cord blood.

Methods: Serum was obtained from 148 birth cohort children at 13 years of age. Forty had atopic eczema, 53 had respiratory allergy, and 55 were nonallergic. Proportions of LCPUFAs were determined in serum phospholipids; cord blood from 128 of the individuals was previously analysed. Seafood intake was estimated using questionnaires.

Results: Allergic and nonallergic individuals did not differ significantly regarding individual LCPUFAs. However, arachidonic acid over docosahexaenoic acid (DHA) ratio was higher in allergic, compared with nonallergic, adolescents. In nonallergic individuals, LCPUFA proportions in cord serum and adolescent serum correlated weakly. In individuals with atopic eczema and respiratory allergy, these correlations were weak or absent. A moderate correlation between seafood intake and serum DHA was seen in nonallergic individuals and those with respiratory allergy, but not in those with atopic eczema.

Conclusion: Serum LCPUFA pattern was similar in allergic and nonallergic adolescents. Fatty acid metabolism may be altered in atopic eczema subjects, suggested by poor correlations between fatty acid intake and serum levels.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2014
Nyckelord
Allergy, Asthma, Atopic eczema, Fatty acids, Polyunsaturated fatty acids
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:umu:diva-93817 (URN)10.1111/apa.12690 (DOI)000341136400022 ()24837739 (PubMedID)
Tillgänglig från: 2014-10-09 Skapad: 2014-10-01 Senast uppdaterad: 2018-06-07Bibliografiskt granskad
Barman, M., Johansson, S., Hesselmar, B., Wold, A. E., Sandberg, A.-S. & Sandin, A. (2013). High Levels of Both n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids in Cord Serum Phospholipids Predict Allergy Development. PLoS ONE, 8(7), e67920
Öppna denna publikation i ny flik eller fönster >>High Levels of Both n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids in Cord Serum Phospholipids Predict Allergy Development
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2013 (Engelska)Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, nr 7, s. e67920-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Long-chain polyunsaturated fatty acids (LCPUFAs) reduce T-cell activation and dampen inflammation. They might thereby counteract the neonatal immune activation and hamper normal tolerance development to harmless environmental antigens. We investigated whether fatty acid composition of cord serum phospholipids affects allergy development up to age 13 years. Methods: From a population-based birth-cohort born in 1996/7 and followed until 13 years of age (n = 794), we selected cases with atopic eczema (n = 37) or respiratory allergy (n = 44), as well as non-allergic non-sensitized controls (n = 48) based on diagnosis at 13 years of age. Cord and maternal sera obtained at delivery from cases and controls were analysed for proportions of saturated, monounsaturated and polyunsaturated fatty acids among serum phospholipids. Results: The cord serum phospholipids from subject who later developed either respiratory allergy or atopic eczema had significantly higher proportions of 5/8 LCPUFA species, as well as total n-3 LCPUFA, total n-6 LCPUFA and total LCPUFA compared to cord serum phospholipids from controls who did not develop allergy (P < 0.001 for all comparisons). Conversely, individuals later developing allergy had lower proportion of the monounsaturated fatty acid 18:1n-9 as well as total MUFA (p < 0.001) among cord serum phospholipids. The risk of respiratory allergy at age 13 increased linearly with the proportion of n-3 LCPUFA (P-trend < 0.001), n-6 LCPUFA (P-trend = 0.001), and total LCPUFA (P-trend < 0.001) and decreased linearly with the proportions of total MUFA (P-trend = 0.025) in cord serum phospholipids. Furthermore, Kaplan-Meier estimates of allergy development demonstrated that total LCPUFA proportion in cord serum phospholipids was significantly associated with respiratory allergy (P = 0.008) and sensitization (P = 0.002), after control for sex and parental allergy. Conclusion: A high proportion of long-chain PUFAs among cord serum phospholipids may predispose to allergy development. The mechanism is unknown, but may involve dampening of the physiologic immune activation in infancy needed for proper maturation of the infant's immune system.

Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-79607 (URN)10.1371/journal.pone.0067920 (DOI)000321765300016 ()
Tillgänglig från: 2013-12-03 Skapad: 2013-08-26 Senast uppdaterad: 2018-06-08Bibliografiskt granskad
Sandin, A., Björkstén, B., Böttcher, M., Jenmalm, M. & Bråbäck, L. (2011). High salivary secretory IgA antibody levels are associated with less late-onset wheezing in IgE-sensitized infants. Pediatric Allergy and Immunology, 22(5), 477-481
Öppna denna publikation i ny flik eller fönster >>High salivary secretory IgA antibody levels are associated with less late-onset wheezing in IgE-sensitized infants
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2011 (Engelska)Ingår i: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 22, nr 5, s. 477-481Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Low levels of secretory IgA (SIgA) and transient IgA deficiency have been associated with an increased risk for allergy, but data are conflicting. The aim was to assess the relationship between salivary SIgA antibody levels at 1 yr and wheezing at age four in a birth cohort, in particular the possible protective role of salivary SIgA in sensitized children. Saliva samples were obtained from all children (n = 67) with a positive skin prick test (SPT) at 1 yr and 212 children with a negative SPT. In all, 200 of these children responded to questionnaires at 4 yrs and 183 were skin prick tested at that age. The levels of salivary SIgA and salivary IgA antibodies to the most common food allergen egg and inhalant allergen cat were analyzed by ELISA. Serum was analyzed for IgE antibodies to egg and cat. Development of late-onset wheezing was associated with low SIgA levels in children with positive SPT to at least one allergen both at 1 and 4 yrs of age (p = 0.04), as well as in children with circulating IgE antibodies to egg or cat at 1 yr (p = 0.02). None of nine persistently sensitized children with SIgA levels in the upper quartile developed wheezing, when compared to 10/20 children with lower levels (p = 0.01). Older siblings, more than three infections during infancy, at least one smoking parent, and male gender, were all associated with SIgA in the upper quartile. In conclusion, high levels of SIgA antibodies in sensitized infants were associated with significantly less late-onset wheezing, supporting a protective role against development of asthmatic symptoms. Recurrent infections and other factors supporting an increased microbial pressure during infancy were associated with high levels of salivary SIgA.

Ort, förlag, år, upplaga, sidor
Copenhagen: Munksgaard International Publ., 2011
Nyckelord
secretory IgA; saliva; sensitization; late-onset wheezing; children
Nationell ämneskategori
Pediatrik
Identifikatorer
urn:nbn:se:umu:diva-3119 (URN)10.1111/j.1399-3038.2010.01106.x (DOI)
Tillgänglig från: 2008-04-29 Skapad: 2008-04-29 Senast uppdaterad: 2019-01-25Bibliografiskt granskad
Sandin, A., Bråbäck, L., Norin, E. & Björkstén, B. (2009). Faecal short chain fatty acid pattern and allergy in early childhood. Acta Paediatrica, 98(5), 823-827
Öppna denna publikation i ny flik eller fönster >>Faecal short chain fatty acid pattern and allergy in early childhood
2009 (Engelska)Ingår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 98, nr 5, s. 823-827Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aim: To investigate whether functional changes of the gut flora over time were related to sensitization and allergic symptoms at four years of age.

Methods: The levels of short chain fatty acids (SCFAs) in faecal samples at one (n = 139) and four (n = 53) years of age were related to the development of positive skin prick tests (SPT) and allergic symptoms during the first four years of life.

Results: Faecal acetic (p < 0.01) and propionic (p < 0.01) acids decreased from one to four years of age, while valeric acid (p < 0.001) increased. Low levels of i-butyric (p = 0.01), i-valeric (p = 0.03) and valeric acids (p = 0.02) at one year were associated with questionnaire-reported symptoms of food allergy at four years. Positive SPTs and allergic symptoms at four years were associated with low faecal levels of i-butyric, i-valeric and valeric acids. At one year of age, infants with, as compared to without older siblings had higher median levels of valeric acid.

Conclusion: A slow functional maturation of the gut microflora, as measured by faecal levels of SCFAs is associated with allergy both at one and four years. The findings lend further support to an association between allergy and the development of microbial diversity.

Nyckelord
Allergic children; Intestinal flora; Short chain fatty acids; Sensitization
Nationell ämneskategori
Pediatrik
Identifikatorer
urn:nbn:se:umu:diva-3118 (URN)10.1111/j.1651-2227.2008.01215.x (DOI)
Tillgänglig från: 2008-04-29 Skapad: 2008-04-29 Senast uppdaterad: 2019-01-25Bibliografiskt granskad
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