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Bourke, Grainne
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Bourke, G., McGrath, A. M., Wiberg, M. & Novikov, L. N. (2018). Effects of early nerve repair on experimental brachial plexus injury in neonatal rats. Journal of Hand Surgery, European Volume, 43(3), 275-281
Öppna denna publikation i ny flik eller fönster >>Effects of early nerve repair on experimental brachial plexus injury in neonatal rats
2018 (Engelska)Ingår i: Journal of Hand Surgery, European Volume, ISSN 1753-1934, E-ISSN 2043-6289, Vol. 43, nr 3, s. 275-281Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Obstetrical brachial plexus injury refers to injury observed at the time of delivery, which may lead to major functional impairment in the upper limb. In this study, the neuroprotective effect of early nerve repair following complete brachial plexus injury in neonatal rats was examined. Brachial plexus injury induced 90% loss of spinal motoneurons and 70% decrease in biceps muscle weight at 28 days after injury. Retrograde degeneration in spinal cord was associated with decreased density of dendritic branches and presynaptic boutons and increased density of astrocytes and macrophages/microglial cells. Early repair of the injured brachial plexus significantly delayed retrograde degeneration of spinal motoneurons and reduced the degree of macrophage/microglial reaction but had no effect on muscle atrophy. The results demonstrate that early nerve repair of neonatal brachial plexus injury could promote survival of injured motoneurons and attenuate neuroinflammation in spinal cord.

Ort, förlag, år, upplaga, sidor
Sage Publications, 2018
Nyckelord
Brachial plexus injury, neonatal rat, spinal cord, motor neuron, cell death
Nationell ämneskategori
Ortopedi Kirurgi
Identifikatorer
urn:nbn:se:umu:diva-147362 (URN)10.1177/1753193417732696 (DOI)000429871600005 ()28950736 (PubMedID)
Tillgänglig från: 2018-05-03 Skapad: 2018-05-03 Senast uppdaterad: 2018-06-09Bibliografiskt granskad
Wade, R. G., Itte, V., Rankine, J. J., Ridgway, J. P. & Bourke, G. (2018). The diagnostic accuracy of 1.5T magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries. Journal of Hand Surgery, European Volume, 43(3), 250-258
Öppna denna publikation i ny flik eller fönster >>The diagnostic accuracy of 1.5T magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries
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2018 (Engelska)Ingår i: Journal of Hand Surgery, European Volume, ISSN 1753-1934, E-ISSN 2043-6289, Vol. 43, nr 3, s. 250-258Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Identification of root avulsions is of critical importance in traumatic brachial plexus injuries because it alters the reconstruction and prognosis. Pre-operative magnetic resonance imaging is gaining popularity, but there is limited and conflicting data on its diagnostic accuracy for root avulsion. This cohort study describes consecutive patients requiring brachial plexus exploration following trauma between 2008 and 2016. The index test was magnetic resonance imaging at 1.5 Tesla and the reference test was operative exploration of the supraclavicular plexus. Complete data from 29 males was available. The diagnostic accuracy of magnetic resonance imaging for root avulsion(s) of C5-T1 was 79%. The diagnostic accuracy of a pseudomeningocoele as a surrogate marker of root avulsion(s) of C5-T1 was 68%. We conclude that pseudomeningocoles were not a reliable sign of root avulsion and magnetic resonance imaging has modest diagnostic accuracy for root avulsions in the context of adult traumatic brachial plexus injuries. Level of evidence: III

Ort, förlag, år, upplaga, sidor
Sage Publications, 2018
Nyckelord
Root avulsion, pre-ganglionic, brachial plexus, magnetic resonance imaging, sensitivity, specificity, agnostic test accuracy
Nationell ämneskategori
Ortopedi Kirurgi
Identifikatorer
urn:nbn:se:umu:diva-147361 (URN)10.1177/1753193417729587 (DOI)000429871600002 ()28886666 (PubMedID)
Tillgänglig från: 2018-05-07 Skapad: 2018-05-07 Senast uppdaterad: 2018-06-09Bibliografiskt granskad
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