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Eriksson Ström, Jonas
Publikationer (3 of 3) Visa alla publikationer
Eriksson Ström, J., Pourazar, J., Linder, R., Blomberg, A., Lindberg, A., Bucht, A. & Behndig, A. F. (2019). Rapid decline in lung function in COPD is associated with decreased CD25brightFoxP3 regulatory T cells in BAL. Paper presented at European-Respiratory-Society (ERS) International Congress, Madrid, SPAIN, SEP 28-OCT 02, 2019.. European Respiratory Journal, 54
Öppna denna publikation i ny flik eller fönster >>Rapid decline in lung function in COPD is associated with decreased CD25brightFoxP3 regulatory T cells in BAL
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2019 (Engelska)Ingår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 54Artikel i tidskrift, Meeting abstract (Övrigt vetenskapligt) Published
Ort, förlag, år, upplaga, sidor
Sheffield: European Respiratory Society Journals, 2019
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-168194 (URN)10.1183/13993003.congress-2019.PA4383 (DOI)000507372405397 ()
Konferens
European-Respiratory-Society (ERS) International Congress, Madrid, SPAIN, SEP 28-OCT 02, 2019.
Anmärkning

Supplement: 63. Meeting Abstract: PA4383.

Tillgänglig från: 2020-03-11 Skapad: 2020-03-11 Senast uppdaterad: 2020-03-11Bibliografiskt granskad
Eriksson Ström, J., Pourazar, J., Linder, R., Blomberg, A., Lindberg, A., Bucht, A. & Behndig, A. F. (2018). Cytotoxic lymphocytes in COPD airways: increased NK cells associated with disease, iNKT and NKT-like cells with current smoking. Respiratory Research, 19, Article ID 244.
Öppna denna publikation i ny flik eller fönster >>Cytotoxic lymphocytes in COPD airways: increased NK cells associated with disease, iNKT and NKT-like cells with current smoking
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2018 (Engelska)Ingår i: Respiratory Research, ISSN 1465-9921, E-ISSN 1465-993X, Vol. 19, artikel-id 244Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Cytotoxic lymphocytes are increased in the airways of COPD patients. Whether this increase is driven primarily by the disease or by smoking is not clear, nor whether it correlates with the rate of decline in lung function.

Methods: Bronchoscopy with BAL was performed in 52 subjects recruited from the longitudinal OLIN COPD study according to pre-determined criteria; 12 with COPD and a rapid decline in lung function (loss of FEV1 ≥ 60 ml/year), 10 with COPD and a non-rapid decline in lung function (loss of FEV1 ≤ 30 ml/year), 15 current and ex-smokers and 15 non-smokers with normal lung function. BAL lymphocyte subsets were determined using flow cytometry.

Results: In BAL fluid, the proportions of NK, iNKT and NKT-like cells all increased with pack-years. Within the COPD group, NK cells – but not iNKT or NKT-like cells – were significantly elevated also in subjects that had quit smoking. In contrast, current smoking was associated with a marked increase in iNKT and NKT-like cells but not in NK cells. Rate of lung function decline did not significantly affect any of the results.

Conclusions: In summary, increased proportions of NK cells in BAL fluid were associated with COPD; iNKT and NKT-like cells with current smoking but not with COPD. Interestingly, NK cell percentages did not normalize in COPD subjects that had quit smoking, indicating that these cells might play a role in the continued disease progression seen in COPD even after smoking cessation.

Trial registration: Clinicaltrials.gov identifier NCT02729220.

Ort, förlag, år, upplaga, sidor
BMC, 2018
Nyckelord
Chronic obstructive pulmonary disease, Disease mechanisms, Lung function decline, Smoking habits, Bronchoalveolar lavage
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
urn:nbn:se:umu:diva-154873 (URN)10.1186/s12931-018-0940-7 (DOI)000452747200001 ()30526599 (PubMedID)2-s2.0-85058092775 (Scopus ID)
Tillgänglig från: 2019-01-04 Skapad: 2019-01-04 Senast uppdaterad: 2020-05-11Bibliografiskt granskad
Lindberg, A., Linder, R., Backman, H., Eriksson Ström, J., Frølich, A., Nilsson, U., . . . Blomberg, A. (2017). From COPD epidemiology to studies of pathophysiological disease mechanisms: challenges with regard to study design and recruitment process. European Clinical Respiratory Journal, 4, Article ID 1415095.
Öppna denna publikation i ny flik eller fönster >>From COPD epidemiology to studies of pathophysiological disease mechanisms: challenges with regard to study design and recruitment process
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2017 (Engelska)Ingår i: European Clinical Respiratory Journal, ISSN 2001-8525, Vol. 4, artikel-id 1415095Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Chronic obstructive pulmonary disease (COPD) is a largely underdiagnosed disease including several phenotypes. In this report, the design of a study intending to evaluate the pathophysiological mechanism in COPD in relation to the specific phenotypes non-rapid and rapid decline in lung function is described together with the recruitment process of the study population derived from a population based study.

Method: The OLIN COPD study includes a population-based COPD cohort and referents without COPD identified in 2002–04 (n = 1986), and thereafter followed annually since 2005. Lung function decline was estimated from baseline in 2002–2004 to 2010 (first recruitment phase) or to 2012/2013 (second recruitment phase). Individuals who met the predefined criteria for the following four groups were identified; group A) COPD grade 2–3 with rapid decline in FEV1 and group B) COPD grade 2–3 without rapid decline in FEV1 (≥60 and ≤30 ml/year, respectively), group C) ever-smokers, and group D) non-smokers with normal lung function. Groups A–C included ever-smokers with >10 pack years. The intention was to recruit 15 subjects in each of the groups A-D.

Results: From the database groups A–D were identified; group A n = 37, group B n = 29, group C n = 41, and group D n = 55. Fifteen subjects were recruited from groups C and D, while this goal was not reached in the groups A (n = 12) and B (n = 10). The most common reasons for excluding individuals identified as A or B were comorbidities contraindicating bronchoscopy, or inflammatory diseases/immune suppressive medication expected to affect the outcome.

Conclusion: The study is expected to generate important results regarding pathophysiological mechanisms associated with rate of decline in lung function among subjects with COPD and the in-detail described recruitment process, including reasons for non-participation, is a strength when interpreting the results in forthcoming studies.

Ort, förlag, år, upplaga, sidor
Taylor & Francis, 2017
Nyckelord
Chronic obstructive pulmonary disease, disease mechanisms, lung function decline, smoking habits
Nationell ämneskategori
Lungmedicin och allergi
Forskningsämne
lungmedicin; epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-143251 (URN)10.1080/20018525.2017.1415095 (DOI)000418831000001 ()
Projekt
OLIN-studierna
Tillgänglig från: 2017-12-19 Skapad: 2017-12-19 Senast uppdaterad: 2020-01-29Bibliografiskt granskad
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