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Karlsson, Marcus
Publications (5 of 5) Show all publications
Lundström, A., Wiklund, U., Winbo, A., Eliasson, H., Karlsson, M. & Rydberg, A. (2023). Cardiac response to water activities in children with Long QT syndrome type 1. PLOS ONE, 18(12), Article ID e0295431.
Open this publication in new window or tab >>Cardiac response to water activities in children with Long QT syndrome type 1
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2023 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 18, no 12, article id e0295431Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Swimming is a genotype-specific trigger in long QT syndrome type 1 (LQT1).

OBJECTIVE: To examine the autonomic response to water activities in children and adolescents with LQT1.

METHODS: In this cross-sectional study, LQT1 patients were age and sex matched to one healthy control subject. Electrocardiograms (ECGs) were recorded during face immersion (FI), swimming, diving, and whole-body submersion (WBS). Heart rate (HR) and heart rate variability (HRV) was measured. The high frequency (HF) component of HRV was interpreted to reflect parasympathetic activity, while the low frequency (LF) component was interpreted as reflecting the combined influence of sympathetic and parasympathetic activity on autonomic nervous modulation of the heart.

RESULTS: Fifteen LQT1 patients (aged 7-19 years, all on beta-blocker therapy) and fifteen age and sex matched non-medicated controls were included. No significant ventricular arrhythmias were observed in the LQT1 population during the water activities. Out of these 15 matched pairs, 12 pairs managed to complete FI and WBS for more than 10 seconds and were subsequently included in HR and HRV analyses. In response to FI, the LQT1 group experienced a drop in HR of 48 bpm, compared to 67 bpm in the control group (p = 0.006). In response to WBS, HR decreased by 48 bpm in the LQT1 group and 70 bpm in the control group (p = 0.007). A significantly lower PTOT (p < 0.001) and HF (p = 0.011) component was observed before, during and after FI in LQT1 patients compared with the controls. Before, during and after WBS, a significantly lower total power (p < 0.001), LF (p = 0.002) and HF (p = 0.006) component was observed in the LQT1 patients.

CONCLUSION: A significantly lower HR decrease in response to water activities was observed in LQT1 subjects on beta-blocker therapy, compared to matched non-medicated controls. The data suggests an impaired parasympathetic response in LQT1 children and adolescents. An aberrant autonomic nervous system (ANS) response may cause an autonomic imbalance in this patient group.

Place, publisher, year, edition, pages
Public Library of Science (PLoS), 2023
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-218679 (URN)10.1371/journal.pone.0295431 (DOI)38060596 (PubMedID)2-s2.0-85179900660 (Scopus ID)
Available from: 2023-12-27 Created: 2023-12-27 Last updated: 2024-03-27Bibliographically approved
Liljegren, A. R., Brorsson, C., Karlsson, M., Koskinen, L.-O. D. & Sundström, N. (2023). Cerebrovascular pressure reactivity measures: index comparison and clinical outcome in patients with traumatic brain injury treated according to an intracranial pressure–focused management. Neurotrauma Reports, 4(1), 848-856
Open this publication in new window or tab >>Cerebrovascular pressure reactivity measures: index comparison and clinical outcome in patients with traumatic brain injury treated according to an intracranial pressure–focused management
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2023 (English)In: Neurotrauma Reports, E-ISSN 2689-288X, Vol. 4, no 1, p. 848-856Article in journal (Refereed) Published
Abstract [en]

The aim was to investigate whether the pressure reactivity indices PRx, long-PRx (L-PRx), and pressure reactivity (PR) are interchangeable as measures of vascular reactivity, and whether they correlate with clinical outcome when an intracranial pressure (ICP)-targeted treatment regimen is applied in patients with traumatic brain injury (TBI). Patients with TBI (n = 29) that arrived at the hospital within 24 h of injury were included. PRx and L-PRx were derived from Pearson correlations between mean arterial pressure (MAP) and ICP over a short- and long-time interval. PR was the regression coefficient between the hourly mean values of ICP and MAP. Indices were compared to each other, parameters at admission, and outcome assessed by the extended Glasgow Outcome Scale-Extended (GOSE) at 6 and 12 months. PRx and L-PRx had the strongest correlation with each other (R = 0.536, p < 0.01). A correlation was also noted between L-PRx and PR (R = 0.475, p < 0.01), but not between PRx and PR. A correlation was found between age and PRx (R = 0.482, p = 0.01). No association with outcome for any of the indices was found. PRx/L-PRx and L-PRx/PR were moderately correlated with each other. Age was associated with PRx. None of the indices correlated with outcome when our ICP treatment regime was applied. Part of our null hypothesis, that the three indices are associated with outcome, must be rejected. There was, however, an association between some of the indices. To further understand the relation of treatment regimes and pressure reactivity indices, a larger, randomized study is warranted.

Place, publisher, year, edition, pages
Mary Ann Liebert, 2023
Keywords
neurointensive care, neurosurgery, pressure reactivity indices, traumatic brain injury
National Category
Neurology
Identifiers
urn:nbn:se:umu:diva-219526 (URN)10.1089/neur.2023.0074 (DOI)2-s2.0-85181575401 (Scopus ID)
Available from: 2024-01-22 Created: 2024-01-22 Last updated: 2024-01-22Bibliographically approved
Surano, S., Grip, H., Öhberg, F., Karlsson, M., Faergemann, E., Bjurman, M., . . . Salzer, J. (2022). Internet-based vestibular rehabilitation versus standard care after acute onset vertigo: a study protocol for a randomized controlled trial. Trials, 23(1), Article ID 496.
Open this publication in new window or tab >>Internet-based vestibular rehabilitation versus standard care after acute onset vertigo: a study protocol for a randomized controlled trial
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2022 (English)In: Trials, E-ISSN 1745-6215, Vol. 23, no 1, article id 496Article in journal (Refereed) Published
Abstract [en]

Background: Dizziness and vertigo affect around 15% of adults annually and represent common reasons for contacting health services, accounting for around 3% of all emergency department visits worldwide. Vertigo is also associated with excessive use of diagnostic imaging and emergency care and decreased productivity, primarily because of work absenteeism. Vestibular rehabilitation is an evidence-based treatment for chronic dizziness and supervised group exercise therapy has recently been shown to be effective after vestibular neuritis, a common cause of acute onset vertigo. However, such interventions are not readily available and there is a need for more easily accessible tools. The purpose of this study is to investigate the effects on vestibular symptoms of a 6-week online vestibular rehabilitation tool after acute onset vertigo, with the aim of aiding vestibular rehabilitation by presenting a more accessible tool that can help to reduce recovery time. Methods: Three hundred twenty individuals diagnosed with acute vestibular syndrome (AVS) will be recruited from multiple hospitals in Sweden and the effects of an online vestibular rehabilitation tool, YrselTräning, on vestibular symptoms after acute onset vertigo will be compared to standard care (written instructions leaflet) in a two-armed, evaluator-blinded, multicenter randomized controlled trial. The primary outcome will be the Vertigo Symptom Scale Short Form (VSS-SF) score at 6 weeks after symptom onset. Secondary outcomes include effects of the intervention on activities of daily living, mood and anxiety, vestibular function recovery, mobility measures, health economic effects, and the reliability of the Swedish VSS-SF translation. Discussion: Participants using the online vestibular rehabilitation tool are expected to recover earlier and to a greater extent from their symptoms as compared to standard care. Since up to 50% of people with AVS without treatment develop persistent symptoms, effective treatment of AVS will likely lead to a higher quality of life and help reduce the societal costs associated with dizziness and vertigo. Trial registration: Clinicaltrials.gov NCT05056324. Registered on September 24, 2021.

Place, publisher, year, edition, pages
Springer Nature, 2022
Keywords
Acute onset vertigo, AVS, Gait function, Internet-based rehabilitation, Multicenter, Online tool, Portable motion sensors, Randomized controlled trial, RCT, Vestibular rehabilitation
National Category
Otorhinolaryngology
Identifiers
urn:nbn:se:umu:diva-203605 (URN)10.1186/s13063-022-06460-0 (DOI)000812260200013 ()35710448 (PubMedID)2-s2.0-85132078781 (Scopus ID)
Available from: 2023-01-19 Created: 2023-01-19 Last updated: 2024-01-17Bibliographically approved
Lundström, A., Karlsson, M., Wiklund, U. & Rydberg, A.Assessment of arrhythmias and heart rate response in healthy adolescents performing face immersion and body submersion in ice-cold water.
Open this publication in new window or tab >>Assessment of arrhythmias and heart rate response in healthy adolescents performing face immersion and body submersion in ice-cold water
(English)Manuscript (preprint) (Other academic)
National Category
Physiology Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-222716 (URN)
Available from: 2024-03-26 Created: 2024-03-26 Last updated: 2024-03-27
Lundström, A., Eliasson, H., Karlsson, M., Wiklund, U. & Rydberg, A.Holter study of heart rate variability in children and adolescents with long QT syndrome.
Open this publication in new window or tab >>Holter study of heart rate variability in children and adolescents with long QT syndrome
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(English)Manuscript (preprint) (Other academic)
National Category
Pediatrics Cardiac and Cardiovascular Systems Physiology
Identifiers
urn:nbn:se:umu:diva-222715 (URN)
Available from: 2024-03-26 Created: 2024-03-26 Last updated: 2024-03-27
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