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Domellöf, Erik
Publications (10 of 54) Show all publications
Lenfeldt, N., Johansson, A.-M., Domellöf, E., Riklund, K. & Rönnqvist, L. (2017). Alterations in white matter microstructure are associated with goal-directed upper-limb movement segmentation in children born extremely preterm. Human Brain Mapping, 38, 5051-5068
Open this publication in new window or tab >>Alterations in white matter microstructure are associated with goal-directed upper-limb movement segmentation in children born extremely preterm
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2017 (English)In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 38, p. 5051-5068Article in journal (Refereed) Published
Abstract [en]

Altered white matter microstructure is commonly found in children born preterm (PT), especially those born at an extremely low gestational age (GA). These children also commonly show disturbed motor function. This study explores the relation between white matter alterations and upperlimb movement segmentation in 41 children born PT (19 girls), and 41 children born at term (18 girls) at 8 years. The PT group was subdivided into extremely PT (E-PT; GA = 25–27 weeks, N = 10), very PT (V-PT; GA = 28–32 weeks, N = 13), and moderately PT (M-PT; GA = 33–35 weeks, N = 18). Arm/hand preference (preferred/non-preferred) was determined through object interactions and the brain hemispheres were designated accordingly. White matter alterations were assessed using diffusion tensor imaging in nine areas, and movement segmentation of the body-parts head, shoulder, elbow, and wrist were registered during a unimanual goal-directed task. Increased movement segmentation was demonstrated consistently on the preferred side in the E-PT group compared with the term born group. Also compared with the term born peers, the E-PT group demonstrated reduced fractional anisotropy (FA) in the cerebral peduncle (targeting the corticospinal tract) in the hemisphere on the non-preferred side and in the splenium of corpus callosum. In contrast, in the anterior internal capsule on the preferred side, the E-PT group had increased FA. Lower FA in the cerebral peduncle, but higher FA in the anterior internal capsule, was associated with increased movement segmentation across body-parts in a contralateral manner. The results suggest that impaired development of sensorimotor tracts in E-PT children could explain a sub-optimal spatiotemporal organization of upper-limb movements.

Place, publisher, year, edition, pages
Hoboken: Wiley-Blackwell, 2017
Keywords
diffusion tensor imaging, anisotropy, sensorimotor, corticospinal, internal capsule, laterality;
National Category
Psychology
Research subject
Radiology; Psychology; Pediatrics
Identifiers
urn:nbn:se:umu:diva-139528 (URN)10.1002/hbm.23714 (DOI)000417002000017 ()28685893 (PubMedID)
Funder
Swedish Research Council, 2011-179
Available from: 2017-09-15 Created: 2017-09-15 Last updated: 2018-06-09Bibliographically approved
Johansson, A.-M., Domellöf, E. & Rönnqvist, L. (2016). Associations between manual dexterity scores from the M-ABC 2 and kinematic properties of goal-directed upper-limb movements and in school-aged children born preterm. In: Challenge the Boundaries: . Paper presented at International Conference on Cerebral Palsy and other Childhood-onset Disabilities Stockholm 1–4 June 2016 (pp. P-Fr-135).
Open this publication in new window or tab >>Associations between manual dexterity scores from the M-ABC 2 and kinematic properties of goal-directed upper-limb movements and in school-aged children born preterm
2016 (English)In: Challenge the Boundaries, 2016, p. P-Fr-135-Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Background

Children born preterm (PT; <38 gestational weeks, GW) are frequently reported to have deviations in motor proficiency. Most studies use standardized test batteries to determine motor function in these children. Few studies have however examined the relations between test battery outcomes and outcomes from more detailed movement analysis.

Aim

To investigate associations between outcomes on the manual dexterity subtests from the Movement-ABC 2 with detailed 3D kinematic registrations during performance of a sensorimotor task with demands on fine motor skills and precision in school-aged children born PT and a comparison group born at full-term (FT).

Methods

As part of an ongoing quasi-longitudinal study, 7-8 year old children born PT (< 36 GW; n = 17) and an aged matched typically developing comparison group (n = 19) performed the M-ABC 2 and a fine motor task where 3D kinematic registration technique was applied. M-ABC 2 scaled scores from the manual dexterity index (MDI) were correlated with kinematic parameters sensitive to planning and on-line control (movement units, distance and speed). Differences between the PT and FT group were also analyzed.

Results

Preliminary analyses show no group differences on the outcomes from the 3D kinematic analyses but differences were evident on two (peg-board and follow-track) of the subtests constituting the MDI and the MDI where children born PT have lower scores than FT. For both groups but in different ways, within-group correlations show some associations between extracted kinematic properties and dexterity outcomes.

Conclusions

As the groups differed on the MDI outcomes it is surprising that none were found on the kinematic properties examined. Further, relatively few associations were found between the kinematic and M-ABC 2 outcomes. Investigation of the influence cognitive and executive functions have on these performances may offer explanations for this inconsistency

National Category
Psychology Medical and Health Sciences
Research subject
Psychology; Pediatrics
Identifiers
urn:nbn:se:umu:diva-125483 (URN)
External cooperation:
Conference
International Conference on Cerebral Palsy and other Childhood-onset Disabilities Stockholm 1–4 June 2016
Funder
Swedish Research Council, Dnr:2011-179
Available from: 2016-09-13 Created: 2016-09-13 Last updated: 2018-06-07
Rönnqvist, L., Domellöf, E., Johansson, A.-M., Faroogi, A., Domellöf, M., Riklund, K., . . . Birgander, R. (2016). Effects of twin-births on IQ, handedness, and brain volumes in 8-years-old preterm born twins and matched singletons: a pilot study. Paper presented at International Conference on Cerebral Palsy and other Childhood-onset Disabilities, Stockholm 1–4 June 2016. Developmental Medicine & Child Neurology, 58(S6), 57
Open this publication in new window or tab >>Effects of twin-births on IQ, handedness, and brain volumes in 8-years-old preterm born twins and matched singletons: a pilot study
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2016 (English)In: Developmental Medicine & Child Neurology, ISSN 0012-1622, E-ISSN 1469-8749, Vol. 58, no S6, p. 57-Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Background: Children born preterm have a high prevalence of long-term cognitive and behavioral disturbances. Still, studies of how preterm-twin-births may effect brain maturation and thus, contribute to long-term effects on brain-behavioral development and functions are rare.

Aim: To investigate whether brain volumes differ between twin (TPB) and singleton preterm born (SPB) and full-term born children (FTB) and associate to long-term cognitive and behavioral outcomes as well as to gestational age (GA), birth weight (BW) and head circumference (BHC) at birth.

Method: A sample of 22 twin born preterm (Mean GA=32.1, BW=1781), 23 matched singletons preterm (Mean GA=31.8, BW=1751), and 22 full-term singletons were included. All children were investigated by means of their cognition functions (WISC-IV), handedness performance index and brain volumes (3 Tesla MRI) at early school ages (M=7.8y) in 40 children (9 TPB, 10 SPB, 21 FTB).

Results: The FTB-children performed better than both TPB and SPB on cognitive performance, and showed higher IQ. Brain volumes, especially Gray matter were stronger associated with IQ in the twins. Furthermore it was found that the SPB singletons had smaller Total Brain volume and less Grey Matter than FTB. The twins showed a higher prevalence of non-right handedness associated to GA, than both SPB and FTB. Independently of birth status, GA, BW and BHC were found to correlate positively with IQ, Total Brain volume, and Gray-and White matter volumes.

Conclusion: Discordant handedness in TPB children and associations to lower GA indicate effect of twin-births on early functional laterality. The overall associations found between low GA/BW and smaller BHC at birth in preterm born and associations with lower IQ and smaller brain volumes at 8-y indicate that a very preterm birth are a higher predictor for long-term effects on brain development and cognitive performance than twin-birth per se.

National Category
Pediatrics Psychology Radiology, Nuclear Medicine and Medical Imaging
Research subject
Psychology
Identifiers
urn:nbn:se:umu:diva-126397 (URN)10.1111/dmcn.126_13241 (DOI)
Conference
International Conference on Cerebral Palsy and other Childhood-onset Disabilities, Stockholm 1–4 June 2016
Funder
Swedish Research Council, 2011-179
Available from: 2016-10-04 Created: 2016-10-04 Last updated: 2018-06-09Bibliographically approved
Hansson, A., Hansson, L., Danielsson, I. & Domellöf, E. (2016). Short- and Long-Term Effects of Child Neuropsychological Assessment With a Collaborative and Therapeutic Approach: A Preliminary Study. Applied neuropsychology. Child, 5(2), 97-106
Open this publication in new window or tab >>Short- and Long-Term Effects of Child Neuropsychological Assessment With a Collaborative and Therapeutic Approach: A Preliminary Study
2016 (English)In: Applied neuropsychology. Child, ISSN 2162-2965, Vol. 5, no 2, p. 97-106Article in journal (Refereed) Published
Abstract [en]

This preliminary study explored if a collaborative and therapeutic approach (CTA) could reduce self-reported psychiatric symptoms (Beck Youth Inventories [BYI]) in children referred for neuropsychological assessment. Participants included 11 children (M-age=12.4 years) receiving CTA, 11 (M-age=12.6 years) receiving parent support, and 9 (M-age=12.3 years) remaining on a waiting list. Contrary to both comparison groups, the CTA group reported fewer psychiatric symptoms on most BYI subscales after intervention, and this decrease was sustained for the Anger and Anxiety subscales at 6-month follow-up. Findings support a potential effectiveness of CTA in the neuropsychological assessment of children in a child psychiatric setting.

Keywords
child psychiatry, child psychology, collaborative and therapeutic approach, neurodevelopmental disorder, neuropsychological assessment
National Category
Applied Psychology
Identifiers
urn:nbn:se:umu:diva-121580 (URN)10.1080/21622965.2014.996646 (DOI)000373937500002 ()25671288 (PubMedID)
External cooperation:
Available from: 2016-06-27 Created: 2016-06-03 Last updated: 2018-06-07Bibliographically approved
Rönnqvist, L., Domellöf, E., Johansson, A.-M., Domellöf, M. & Faroogi, A. (2015). Cognitive performance and behavioral functions in relation to gestational age (GA) at birth. Paper presented at Special Issue: Abstracts of the European Academy of Childhood Disability 27th Annual Meeting, 27–30 May 2015, Copenhagen, Denmark. Developmental Medicine & Child Neurology, 57(Suppl s4), 21
Open this publication in new window or tab >>Cognitive performance and behavioral functions in relation to gestational age (GA) at birth
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2015 (English)In: Developmental Medicine & Child Neurology, ISSN 0012-1622, E-ISSN 1469-8749, Vol. 57, no Suppl s4, p. 21-Article in journal (Refereed) Published
Abstract [en]

Introduction:

It is well established that a very preterm birth (PT) relates to increased behavioral problems. The aim of this study was to investigate effects and associations between different gestational ages (GA) at birth (term, late-to-extreme) and later functions. This study is part of an ongoing, longitudinal project.

Participants and Methods:

Test outcomes from WISC-IV and Achenbach’s Child-Behavior-Checklist (CBCL) in children tested at 7-8-years (M=7.7) were used to investigate group differences as effect of GA at birth. In total, 64 preterm born (PT), GA range 22-36, (divided into groups of 14 extremely-PT/EPT, 17 very-PT/VPT, and 33 moderately PT/MPT) and 64 term born (TB), were included. Additionally, associations between GA, birth weight (BW), and outcomes from WISC-IV and CBCL were investigated.

Results:

Multivariate analyses of variance (MANOVA) revealed significantly (p < .05) poorer WISC outcomes on Verbal Comprehension Index, Perceptual Reasoning Index, and on Full-Scale-IQ for children born EPT/VPT in comparison to MPT and TB born. Parents’ CBCL ratings reveled that EPT children had significantly higher prevalence of Attention problems, Thought problems, Aggressive and Somatic complaints. Including the PT-group only shown significant positive correlations between GA/BW respectively and full scale IQ. Higher GA/BW was related to increasing IQ scores.  Significant negative correlations were seen between GA/BW respectively and TotProblem/CBCL-scale. Additionally, CBCL/DSM-Oriented Scales; Adhd-, Opposite-, and Conduct-Problems correlated significantly negative with GA/BW in the PT-born children.

Conclusion:

Our study provides further support for associations between increased risk of cognitive and behavior problems with decreasing GA/BW at birth.

Place, publisher, year, edition, pages
John Wiley & Sons, 2015
National Category
Social Sciences
Research subject
Psychology; Pediatrics
Identifiers
urn:nbn:se:umu:diva-104222 (URN)10.1111/dmcn.12778_46 (DOI)
Conference
Special Issue: Abstracts of the European Academy of Childhood Disability 27th Annual Meeting, 27–30 May 2015, Copenhagen, Denmark
Funder
Swedish Research Council, Dnr:2011-179
Available from: 2015-06-08 Created: 2015-06-08 Last updated: 2018-06-07Bibliographically approved
Domellöf, E., Johansson, A.-M., Farooqi, A., Domellöf, M. & Rönnqvist, L. (2015). Improved fine motor performance in children born preterm: a longitudinal study of upper-limb kinematics from 4 to 8 years. In: : . Paper presented at The 27th annual meeting of the European Academy of Childhood Disability in Copenhagen, Denmark on May 27-30, 2015 (pp. 39). , 57
Open this publication in new window or tab >>Improved fine motor performance in children born preterm: a longitudinal study of upper-limb kinematics from 4 to 8 years
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2015 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Introduction:

Although children born preterm (PT) are at known risk for impaired neuromotor development, longitudinal studies using detailed measurements of motor performance are rare. This study investigated developmental changes in goal-directed upper-limb kinematics from 4-8 years old in a sample of children born fullterm (FT) and PT without known developmental disabilities.

Participants and Methods:

3D kinematic recordings of performance with either arm/hand during a goal-directed unimanual precision task were carried out at 4 and 8 years in 37 children (13 very PT, V-PT, < 32 GW; 5 moderately PT, M-PT, 33-35 GW; 19 FT).

Results:

Repeated measures ANOVA revealed significant main effects for group and occasion, and interaction effects between group and occasion, for distal movement duration (p < .0001) and segmentation in terms of movement units (MUs, p < .0001). From initially having displayed less proficient movement organization at 4 years than both children born FT and M-PT, the children born V-PT showed a marked catch-up at 8 years, where no significant group differences remained. The mean between-occasion difference was substantial for both duration and segmentation in V-PT relative the other groups, although with noticeably higher within-group variability (MSD = 1.2 s/7.8 MUs) than M-PT (MSD = 0.5 s/2.5 MUs) and FT (MSD = 0.5 s/4.2 MUs).

Conclusion:

The children born PT, V-PT in particular, generally displayed a considerable gain in fine motor performance from preschool to school age. Compared with the FT and M-PT groups, however, the rate of improvement appears more heterogeneous in the V-PT group

Series
Developmental Medicine and Child Neurology, ISSN 1469-8749
National Category
Pediatrics
Research subject
Pediatrics; Psychology
Identifiers
urn:nbn:se:umu:diva-108323 (URN)10.1111/dmcn.12780_37 (DOI)
Conference
The 27th annual meeting of the European Academy of Childhood Disability in Copenhagen, Denmark on May 27-30, 2015
Funder
Swedish Research Council, Dnr:2011-179
Available from: 2015-09-08 Created: 2015-09-08 Last updated: 2018-06-07Bibliographically approved
Domellöf, E., Barbu-Roth, M., Rönnqvist, L., Jacquet, A.-Y. & Fagard, J. (2015). Infant manual performance during reaching and grasping for objects moving in depth. Frontiers in Psychology, 6, Article ID 1142.
Open this publication in new window or tab >>Infant manual performance during reaching and grasping for objects moving in depth
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2015 (English)In: Frontiers in Psychology, ISSN 1664-1078, E-ISSN 1664-1078, Vol. 6, article id 1142Article in journal (Refereed) Published
Abstract [en]

Few studies have investigated manual performance in infants when reaching and grasping for objects moving in directions other than across the fronto-parallel plane. The present preliminary study explored object-oriented behavioral strategies and side preference in 8- and 10-month-old infants during reaching and grasping for objects approaching in depth from three positions (midline, and 27° diagonally from the left and right). Effects of task constraint by using objects of three different types and two sizes were further examined for behavioral strategies and hand opening prior to grasping. Additionally, assessments of hand preference by a dedicated handedness test were performed. Regardless of object starting position, the 8-month-old infants predominantly displayed right-handed reaches for objects approaching in depth. In contrast, the older infants showed more varied strategies and performed more ipsilateral reaches in correspondence with the side of the approaching object. Conversely, 10-month-old infants were more successful than the younger infants in grasping the objects, independent of object starting position. The findings regarding infant hand use strategies when reaching and grasping for objects moving in depth are similar to those from earlier studies using objects moving along a horizontal path. Still, initiation times of reaching onset were generally long in the present study, indicating that the object motion paths seemingly affected how the infants perceived the intrinsic properties and spatial locations of the objects, possibly with an effect on motor planning. Findings are further discussed in relation to future investigations of infant reaching and grasping for objects approaching in depth.

Keywords
infants, reaching, grasping, handedness, moving objects
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:umu:diva-107937 (URN)10.3389/fpsyg.2015.01142 (DOI)000359794500001 ()
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2006-1577
Available from: 2015-08-31 Created: 2015-08-31 Last updated: 2018-06-07Bibliographically approved
Ferronato, P. A. M., Domellöf, E. & Rönnqvist, L. (2014). Early influence of auditory stimuli on upper-limb movements in young human infants: an overview. Frontiers in Psychology, 5(1043)
Open this publication in new window or tab >>Early influence of auditory stimuli on upper-limb movements in young human infants: an overview
2014 (English)In: Frontiers in Psychology, ISSN 1664-1078, E-ISSN 1664-1078, Vol. 5, no 1043Article, review/survey (Refereed) Published
Abstract [en]

Given that the auditory system is rather well developed at the end of the third trimester of pregnancy, it is likely that couplings between acoustics and motor activity can be integrated as early as at the beginning of postnatal life. The aim of the present mini-review was to summarize and discuss studies on earlyauditory-motor integration, focusing particularly on upper-limb movements (one of the most crucial means to interact with the environment) in association with auditory stimuli, to develop further understanding of their significance with regard to early infant development. Many studies have investigated the relationship between various infant behaviors (e.g., sucking, visual fixation,head turning) and auditory stimuli, and established that human infants can beobserved displaying couplings between action and environmental sensory stimulation already from just after birth, clearly indicating a propensity forintentional behavior. Surprisingly few studies, however, have investigated the associations between upper-limb movements and different auditory stimuli in newborns and young infants, infants born at risk for developmental disorders/delays in particular. Findings from studies of early auditory-motor interaction support that the developing integration of sensory and motor systems is a fundamental part of the process guiding the development of goal-directed action in infancy, of great importance for continued motor, perceptual, and cognitive development. At-risk infants (e.g., those bornpreterm) may display increasing central auditory processing disorders,negatively affecting early sensory-motor integration, and resulting inlong-term consequences on gesturing, language development, and social communication. Consequently, there is a need for more studies on such implications.

Place, publisher, year, edition, pages
Progressive Frontiers Press, 2014
Keywords
review, auditory-motorinteraction, upper-limb movements, newborns, infants, development, atypical development
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:umu:diva-93418 (URN)10.3389/fpsyg.2014.01043 (DOI)000341943600001 ()25278927 (PubMedID)
Funder
Swedish Research Council, 2011-179
Note

CAPES, Brazil (Process 1592412-2)

Available from: 2014-09-20 Created: 2014-09-20 Last updated: 2018-06-07Bibliographically approved
Domellöf, E., Hedlund, L. & Ödman, P. (2014). Health-related quality of life of children and adolescents with functional disabilities in a northern Swedish county. Quality of Life Research, 23(6), 1877-1882
Open this publication in new window or tab >>Health-related quality of life of children and adolescents with functional disabilities in a northern Swedish county
2014 (English)In: Quality of Life Research, ISSN 0962-9343, E-ISSN 1573-2649, Vol. 23, no 6, p. 1877-1882Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Health-related quality of life (HRQoL) studies in children and adolescents with disabilities tend to report lower self-reported health than in the typical population. However, reports are not always consistent and HRQoL appears to vary depending on diagnosis, cultural setting and clinical context. The aim of this study was to explore HRQoL in children and adolescents with various disabilities in Västerbotten County, Sweden.

METHODS: A total of 175 children and adolescents [57 girls, 118 boys; mean age 11.7 years (range 7-17 years)] divided into four different diagnostic groups (intellectual disabilities, autism spectrum disorders, movement disorders and hearing disabilities) participated in the study. The EuroQol Five Dimensions Health Questionnaire, Youth version (EQ-5D-Y) was used as HRQoL measure.

RESULTS: Significant differences in various EQ-5D-Y dimensions between the different diagnostic groups were found, but no differences in overall health status. HRQoL in children and adolescents with hearing disabilities was found similar to the typical child population in Sweden whereas children and adolescents with other diagnoses reported evidently more problems.

CONCLUSIONS: Findings suggest that there is an increased risk for children with functional disabilities other than hearing disabilities in northern Sweden to experience difficulties in various health domains and lowered general health.

Place, publisher, year, edition, pages
Springer Science+Business Media B.V., 2014
Keywords
children, disability, health-related quality of life, EQ-5D-Y
National Category
Psychology Public Health, Global Health, Social Medicine and Epidemiology Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-86313 (URN)10.1007/s11136-013-0613-4 (DOI)000339280700021 ()
Available from: 2014-02-22 Created: 2014-02-22 Last updated: 2018-06-08Bibliographically approved
Rönnqvist, L., Johansson, A.-M. & Domellöf, E. (2014). Kinematic analysis of sequential goal-directed movements in at-risk, preterm born children. Gait & Posture, 39(Suppl 1), 22
Open this publication in new window or tab >>Kinematic analysis of sequential goal-directed movements in at-risk, preterm born children
2014 (English)In: Gait & Posture, ISSN 0966-6362, E-ISSN 1879-2219, Vol. 39, no Suppl 1, p. 22-Article in journal, Meeting abstract (Other academic) Published
National Category
Psychology Pediatrics
Identifiers
urn:nbn:se:umu:diva-94523 (URN)10.1016/j.gaitpost.2014.04.032 (DOI)
Funder
Swedish Research Council, Dnr: 2011-179
Available from: 2014-10-10 Created: 2014-10-10 Last updated: 2018-06-07Bibliographically approved
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