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Publications (10 of 58) Show all publications
Wang, T., Li, M., Gu, Z., Qu, C., Segervald, J., Salh, R., . . . Kou, W. (2024). Fluoride releasing in polymerblends of poly(ethylene oxide) and poly(methyl methacrylate). Frontiers in Chemistry, 12, Article ID 1356029.
Open this publication in new window or tab >>Fluoride releasing in polymerblends of poly(ethylene oxide) and poly(methyl methacrylate)
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2024 (English)In: Frontiers in Chemistry, E-ISSN 2296-2646, Vol. 12, article id 1356029Article in journal (Refereed) Published
Abstract [en]

Introduction: Polymethyl methacrylate is a polymer commonly used in clinicaldentistry, including denture bases, occlusal splints and orthodontic retainers.

Methods: To augment the polymethyl methacrylate-based dental appliances incounteracting dental caries, we designed a polymer blend film composed ofpolymethyl methacrylate and polyethylene oxide by solution casting and addedsodium fluoride.

Results: Polyethylene oxide facilitated the dispersion of sodium fluoride,decreased the surface average roughness, and positively influenced thehydrophilicity of the films. The blend film made of polymethyl methacrylate,polyethylene oxide and NaF with a mass ratio of 10: 1: 0.3 showed sustainedrelease of fluoride ions and acceptable cytotoxicity. Antibacterial activity of all thefilms to Streptococcus mutans was negligible.

Discussion: This study demonstrated that the polymer blends of polyethyleneoxide and polymethyl methacrylate could realize the relatively steady release offluoride ions with high biocompatibility. This strategy has promising potential toendow dental appliances with anti-cariogenicity.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2024
Keywords
dental materials, polymethyl methacrylate, polyethylene oxide, fluoride ion release, polymer blend
National Category
Medical and Health Sciences Dentistry
Identifiers
urn:nbn:se:umu:diva-220718 (URN)10.3389/fchem.2024.1356029 (DOI)2-s2.0-85185521631 (Scopus ID)
Funder
Region Västerbotten, RV-937838The Kempe Foundations, JCSMK22-0122The Kempe Foundations, SMK-21-0015Swedish Research Council, 2021-04778Swedish Research Council, 2020-04437
Available from: 2024-02-09 Created: 2024-02-09 Last updated: 2024-02-29Bibliographically approved
Han, J., Deng, H., Li, Y., Qiao, L., Jia, H., Zhang, L., . . . Qu, C. (2023). Nano-elemental selenium particle developed via supramolecularself-assembly of chondroitin sulfate A and Na2SeO3 to repaircartilage lesions. Carbohydrate Polymers, 316, Article ID 121047.
Open this publication in new window or tab >>Nano-elemental selenium particle developed via supramolecularself-assembly of chondroitin sulfate A and Na2SeO3 to repaircartilage lesions
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2023 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 316, article id 121047Article in journal (Refereed) Published
Abstract [en]

Cartilage repair is a significant clinical issue due to its restricted ability to regenerate and self-heal after cartilage lesions or degenerative disease. Herein, a nano-elemental selenium particle (chondroitin sulfate A‑selenium nanoparticle, CSA-SeNP) is developed by the supramolecular self-assembly of Na2SeO3 and negatively charged chondroitin sulfate A (CSA) via electrostatic interactions or hydrogen bonds followed by in-situ reducing of l-ascorbic acid for cartilage lesions repair. The constructed micelle exhibits a hydrodynamic particle size of 171.50 ± 2.40 nm and an exceptionally high selenium loading capacity (9.05 ± 0.03 %) and can promote chondrocyte proliferation, increase cartilage thickness, and improve the ultrastructure of chondrocytes and organelles. It mainly enhances the sulfation modification of chondroitin sulfate by up-regulating the expression of chondroitin sulfate 4-O sulfotransferase-1, −2, −3, which in turn promotes the expression of aggrecan to repair articular and epiphyseal-plate cartilage lesions. The micelles combine the bio-activity of CSA with selenium nanoparticles (SeNPs), which are less toxic than Na2SeO3, and low doses of CSA-SeNP are even superior to inorganic selenium in repairing cartilage lesions in rats. Thus, the developed CSA-SeNP is anticipated to be a promising selenium supplementation preparation in clinical application to address the difficulty of healing cartilage lesions with outstanding repair effects.

Place, publisher, year, edition, pages
Elsevier, 2023
Keywords
Nano-elemental selenium particle, Chondroitin sulfate A, Cartilage repair, Chondroitin sulfate 4-O sulfotransferase, Aggrecan
National Category
Cell and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-209020 (URN)10.1016/j.carbpol.2023.121047 (DOI)001013063000001 ()2-s2.0-85160736235 (Scopus ID)
Available from: 2023-06-02 Created: 2023-06-02 Last updated: 2023-09-05Bibliographically approved
Deng, H., Xiao, X., Chilufya, M. M., Qiao, L., Lv, Y., Guo, Z., . . . Qu, C. (2022). Altered Expression of the Hedgehog Pathway Proteins BMP2, BMP4, SHH, and IHH Involved in Knee Cartilage Damage of Patients With Osteoarthritis and Kashin-Beck Disease. Cartilage, 13(1), Article ID 19476035221087706.
Open this publication in new window or tab >>Altered Expression of the Hedgehog Pathway Proteins BMP2, BMP4, SHH, and IHH Involved in Knee Cartilage Damage of Patients With Osteoarthritis and Kashin-Beck Disease
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2022 (English)In: Cartilage, ISSN 1947-6035, E-ISSN 1947-6043, Vol. 13, no 1, article id 19476035221087706Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate the expression of Hedgehog (HH) signaling pathway proteins in knee articular cartilage from Kashin-Beck disease (KBD) and osteoarthritis (OA) patients.

METHODS: Knee articular cartilage samples were collected from normal (N), OA, and KBD adults (aged 38-60 years) and divided into 3 groups with 6 subjects in each group. The localization of the HH pathway proteins bone morphogenetic protein 2 (BMP2), bone morphogenetic protein 4 (BMP4), Sonic hedgehog (SHH), and Indian hedgehog (IHH) was observed with the microscope after immunohistochemical (IHC) staining. Positive staining cell rates of each proteins were compared.

RESULTS: The strongest stainings of all proteins were observed in the middle zones of all 3 groups. The positive staining rates of BMP4 and IHH were significantly lower in the OA and KBD groups than those in the N group in all 3 zones. The positive staining rates of BMP2 and SHH tend to be lower in the OA and KBD groups than those in the N group in the deep zone, while higher in the OA and KBD groups than those in the N group in superficial and middle zones.

CONCLUSIONS: Altered expression of the HH pathway proteins BMP2, BMP4, SHH, and IHH was found in OA and KBD articular cartilage. There seemed to be a compensatory effect between SHH and IHH in cartilage damage. Further studies on the pathogenesis of OA and KBD may be carried out from these aspects in the future.

Place, publisher, year, edition, pages
Sage Publications, 2022
Keywords
articular cartilage, Hedgehog pathway, immunohistochemistry, Kashin-Beck disease, osteoarthritis
National Category
Orthopaedics Cell and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-193591 (URN)10.1177/19476035221087706 (DOI)000773766000001 ()35313742 (PubMedID)2-s2.0-85126884872 (Scopus ID)
Available from: 2022-04-13 Created: 2022-04-13 Last updated: 2023-03-24Bibliographically approved
Koskinen Holm, C. & Qu, C. (2022). Engineering a 3D In Vitro Model of Human Gingival Tissue Equivalent with Genipin/Cytochalasin D. International Journal of Molecular Sciences, 23(13), Article ID 7401.
Open this publication in new window or tab >>Engineering a 3D In Vitro Model of Human Gingival Tissue Equivalent with Genipin/Cytochalasin D
2022 (English)In: International Journal of Molecular Sciences, ISSN 1661-6596, E-ISSN 1422-0067, Vol. 23, no 13, article id 7401Article in journal (Refereed) Published
Abstract [en]

Although three-dimensional (3D) co-culture of gingival keratinocytes and fibroblasts-populated collagen gel can mimic 3D structure of in vivo tissue, the uncontrolled contraction of collagen gel restricts its application in clinical and experimental practices. We here established a stable 3D gingival tissue equivalent (GTE) using hTERT-immortalized gingival fibroblasts (hGFBs)-populated collagen gel directly crosslinked with genipin/cytochalasin D and seeding hTERT-immortalized gingival keratinocytes (TIGKs) on the upper surface for a 2-week air–liquid interface co-culture. MTT assay was used to measure the cell viability of GTEs. GTE size was monitored following culture period, and the contraction was analyzed. Immunohistochemical assay was used to analyze GTE structure. qRT-PCR was conducted to examine the mRNA expression of keratinocyte-specific genes. Fifty µM genipin (G50) or combination (G + C) of G50 and 100 nM cytochalasin D significantly inhibited GTE contraction. Additionally, a higher cell viability appeared in GTEs crosslinked with G50 or G + C. GTEs crosslinked with genipin/cytochalasin D showed a distinct multilayered stratified epithelium that expressed keratinocyte-specific genes similar to native gingiva. Collagen directly crosslinked with G50 or G + C significantly reduced GTE contraction without damaging the epithelium. In summary, the TIGKs and hGFBs can successfully form organotypic multilayered cultures, which can be a valuable tool in the research regarding periodontal disease as well as oral mucosa disease. We conclude that genipin is a promising crosslinker with the ability to reduce collagen contraction while maintaining normal cell function in collagen-based oral tissue engineering.

Place, publisher, year, edition, pages
MDPI, 2022
Keywords
cytochalasin D, genipin, gingival tissue equivalent (GTE), hTERT-immortalized gingival fibroblasts (hGFBs), hTERT-immortalized gingival keratinocytes (TIGKs), three-dimensional (3D)
National Category
Dentistry
Research subject
Odontology
Identifiers
urn:nbn:se:umu:diva-197997 (URN)10.3390/ijms23137401 (DOI)000825599100001 ()35806407 (PubMedID)2-s2.0-85133195429 (Scopus ID)
Funder
Wallenberg Foundations, RV-812171 WCMMRegion Västerbotten, RV-937484
Available from: 2022-07-11 Created: 2022-07-11 Last updated: 2023-09-05Bibliographically approved
Lyu, Y., Deng, H., Qu, C., Qiao, L., Liu, X., Xiao, X., . . . Lammi, M. (2022). Identification of proteins and N-glycosylation sites of knee cartilage in Kashin-Beck Disease compared with osteoarthritis. International Journal of Biological Macromolecules, 210, 128-138
Open this publication in new window or tab >>Identification of proteins and N-glycosylation sites of knee cartilage in Kashin-Beck Disease compared with osteoarthritis
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2022 (English)In: International Journal of Biological Macromolecules, ISSN 0141-8130, E-ISSN 1879-0003, Vol. 210, p. 128-138Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to identify crucial proteins and N-glycosylated sites in the pathological mechanism of Kashin-Beck Disease (KBD) compared with osteoarthritis (OA). Nine KBD knee subjects and nine OA knee subjects were selected for the study. Quantitative proteomics and N-glycoproteomics data of KBD and OA were obtained by protein and N-glycoprotein enrichment and LC-MS/MS analysis. Differentially expressed proteins or N-glycosylation sites were examined with a comparative analysis between KBD and OA. Total 2205 proteins were identified in proteomic analysis, of which 375 were significantly different. Among these, 121 proteins were up-regulated and 254 were down-regulated. In N-glycoproteomic analysis, 278 different N-glycosylated sites that were related to 187 N-glycoproteins were identified. Proteins and their N-glycosylated sites are associated with KBD pathological process including ITGB1, LRP1, ANO6, COL1A1, MXRA5, DPP4, and CSPG4. CRLF1 and GLG1 are proposed to associate with both KBD and OA pathological processes. Key pathways in KBD vs. OA proteomic and N-glycoproteomic analysis contained extracellular matrix receptor interaction, focal adhesion, phagosome, protein digestion, and absorption. N-glycosylation may influence the pathological process by affecting the integrity of chondrocytes or cartilage. It regulated the intercellular signal transduction pathway, which contributes to cartilage destruction in KBD.

Place, publisher, year, edition, pages
Elsevier, 2022
Keywords
Kashin-Beck disease, N-glycoproteomics, N-glycosylated sites, Osteoarthritis, Proteomics
National Category
Biochemistry and Molecular Biology Cell and Molecular Biology Orthopaedics
Research subject
Biochemistry; rheumatology; Orthopaedics
Identifiers
urn:nbn:se:umu:diva-194606 (URN)10.1016/j.ijbiomac.2022.05.014 (DOI)000806361400005 ()35526762 (PubMedID)2-s2.0-85129751455 (Scopus ID)
Available from: 2022-05-11 Created: 2022-05-11 Last updated: 2023-09-05Bibliographically approved
Zhao, Y., Sheng, Y., Zhou, J., Wang, H., Chilufya, M. M., Liu, X., . . . Qu, C. (2022). Influencing factors of residents’ environmental health literacy in Shaanxi province, China: a cross‑sectional study. BMC Public Health, 22(1), Article ID 114.
Open this publication in new window or tab >>Influencing factors of residents’ environmental health literacy in Shaanxi province, China: a cross‑sectional study
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2022 (English)In: BMC Public Health, E-ISSN 1471-2458, Vol. 22, no 1, article id 114Article in journal (Refereed) Published
Abstract [en]

Background: This study comprehensively analyzed the basic conditions and influencing factors of the residents' environmental health literacy (EHL) level in Shaanxi Province, China in 2020, and provided a scientific basis for exploring new ideas and new methods to improve the EHL level of the whole people.

Methods: In the cross-sectional study with a multi-stage random sampling method, 1320 participants were recruited in 6 neighborhood committees (administrative villages) from the Shaanxi province of China between 15-69 years old. The Core Questions for Assessment of EHL of Chinese Citizens (Trial Implementation) was adopted to measure the EHL of the respondents.

Results: The survey showed the level of EHL of residents is 17.6% in Shaanxi in 2020. Among them, the basic concepts, basic knowledge, and basic skills classification literacy levels are 34.7%, 6.89%, and 37.95% respectively. The EHL ratio of rural residents is significantly lower than that of urban residents (12.38 vs. 29.02%). A noticeable difference was shown in various aspects and environmental health issues of EHL between urban and rural populations.

Conclusions: Many factors are affecting the level of EHL. Education and science popularization of basic environmental and health knowledge in key areas and populations should be strengthened, and behavioral interventions should be carried out according to the characteristics of the population.

Place, publisher, year, edition, pages
BioMed Central, 2022
Keywords
Environmental health literacy, Influencing factor, Urban, Rural, Health promotion
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-191684 (URN)10.1186/s12889-022-12561-x (DOI)000744348300006 ()35039043 (PubMedID)2-s2.0-85123119136 (Scopus ID)
Available from: 2022-01-21 Created: 2022-01-21 Last updated: 2023-09-05Bibliographically approved
Deng, H., Liu, H., Yang, Z., Bao, M., Lin, X., Han, J. & Qu, C. (2022). Progress of selenium deficiency in the pathogenesis of arthropathies and selenium supplement for their treatment. Biological Trace Element Research, 200, 4238-4249
Open this publication in new window or tab >>Progress of selenium deficiency in the pathogenesis of arthropathies and selenium supplement for their treatment
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2022 (English)In: Biological Trace Element Research, ISSN 0163-4984, E-ISSN 1559-0720, Vol. 200, p. 4238-4249Article, review/survey (Refereed) Published
Abstract [en]

Selenium, an essential trace element for human health, exerts an indispensable effect in maintaining physiological homeostasis and functions in the body. Selenium deficiency is associated with arthropathies, such as Kashin-Beck disease, rheumatoid arthritis, osteoarthritis, and osteoporosis. Selenium deficiency mainly affects the normal physiological state of bone and cartilage through oxidative stress reaction and immune reaction. This review aims to explore the role of selenium deficiency and its mechanisms existed in the pathogenesis of arthropathies. Meanwhile, this review also summarized various experiments to highlight the crucial functions of selenium in maintaining the homeostasis of bone and cartilage.

Place, publisher, year, edition, pages
Springer Nature, 2022
Keywords
Arthropathies, Kashin-Beck disease, Osteoarthritis, Osteoporosis, Rheumatoid arthritis, Selenium deficiency
National Category
Cell and Molecular Biology Orthopaedics Rheumatology and Autoimmunity
Identifiers
urn:nbn:se:umu:diva-189829 (URN)10.1007/s12011-021-03022-4 (DOI)000718695100001 ()34779998 (PubMedID)2-s2.0-85119061363 (Scopus ID)
Available from: 2021-11-23 Created: 2021-11-23 Last updated: 2022-12-01Bibliographically approved
Liu, H., Wu, C., Zhao, H., Zhang, F., Zhao, G., Lin, X., . . . Guo, X. (2022). The first human induced pluripotent stem cell line of Kashin–Beck disease reveals involvement of heparan sulfate proteoglycan biosynthesis and PPAR pathway. The FEBS Journal, 289(1), 279-293
Open this publication in new window or tab >>The first human induced pluripotent stem cell line of Kashin–Beck disease reveals involvement of heparan sulfate proteoglycan biosynthesis and PPAR pathway
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2022 (English)In: The FEBS Journal, ISSN 1742-464X, E-ISSN 1742-4658, Vol. 289, no 1, p. 279-293Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Kashin-Beck disease (KBD) is an endemic osteochondropathy. Due to a lack of suitable animal or cellular disease models, the research progress on KBD has been limited. Our goal was to establish the first disease-specific human induced pluripotent stem cells (hiPSCs) cellular disease model of KBD, and to explore its etiology and pathogenesis exploiting transcriptome sequencing.

METHODS: HiPSCs were reprogrammed from dermal fibroblasts of two KBD and one healthy control donors via integration-free vectors. Subsequently, hiPSCs were differentiated into chondrocytes through three-week culture. Gene expression profiles in KBD, normal primary chondrocytes and hiPSC-derived chondrocytes were defined by RNA sequencing. A Venn diagram was constructed to show the number of shared differentially expressed genes (DEGs) between KBD and normal. Gene oncology and Kyoto Encyclopedia of Genes and Genomes annotations were performed, and six DEGs were further validated in other individuals by real-time quantitative reverse transcription PCR (RT-qPCR).

RESULTS: KBD cellular disease models were successfully established by generation of hiPSC lines. Seventeen consistent and significant DEGs present in all compared groups (KBD and normal) were identified. RT-qPCR validation gave consistent results with the sequencing data. Glycosaminoglycan biosynthesis-heparan sulfate/heparin, PPAR signaling pathway and cell adhesion molecules (CAMs) pathways were identified to be significantly altered in KBD.

CONCLUSION: Differentiated chondrocytes deriving from KBD-origin hiPSCs provide the first cellular disease model for etiological studies of KBD. This study also provides new sights into the pathogenesis and etiology of KBD and is likely to inform the development of targeted therapeutics for its treatment.

Place, publisher, year, edition, pages
John Wiley & Sons, 2022
Keywords
Chondrogenesis, Disease model, Heparan sulfate proteoglycans, Human induced pluripotent stem cells, Kashin-Beck disease
National Category
Orthopaedics Cell and Molecular Biology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Rheumatology and Autoimmunity
Research subject
cell research; Orthopaedics; rheumatology
Identifiers
urn:nbn:se:umu:diva-186450 (URN)10.1111/febs.16143 (DOI)000682366500001 ()34324261 (PubMedID)2-s2.0-85112624359 (Scopus ID)
Available from: 2021-08-02 Created: 2021-08-02 Last updated: 2022-01-25Bibliographically approved
Xiao, X., Deng, H., Chilufya, M. M., Lv, Y., Zhao, Y., Liu, J., . . . Qu, C. (2021). Chondroitin Sulfate and Hyaluronic Acid Perfusion for Interstitial Cystitis/Bladder Pain Syndrome: A Systematic Review and Meta-Analysis. Science Insights, 39(4), 361-373
Open this publication in new window or tab >>Chondroitin Sulfate and Hyaluronic Acid Perfusion for Interstitial Cystitis/Bladder Pain Syndrome: A Systematic Review and Meta-Analysis
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2021 (English)In: Science Insights, ISSN 2372-8191, Vol. 39, no 4, p. 361-373Article, review/survey (Refereed) Published
Abstract [en]

Currently, no suitable delivery methods are available for the drugs to interstitial cystitis/ bladder pain syndrome (IC/BPS). Herein we systematically evaluated the therapeutic effects of intravesical infusion of hyaluronic acid (HA) and chondroitin sulfate (CS) in patients with IC/BPS. This study includes randomized controlled trials (RCT) and self-controlled studies of IC/BPS patients treated with HA, CS, or both. English databases like PubMed, Cochrane Library, Embase, and Medline were searched until up to January 31, 2021. Information was extracted based on the inclusion and exclusion criteria, and then meta-analysis was performed. Sixteen studies including 491 patients were included and analyzed. The responsive rate of treatment was 91.24%. In 3 RCTs, the analogue scale (VAS) for pain on fix-effect model was [mean difference, MD -0.57 (95%CI, -1.55, -0.41)]. A significant improvement on random-effect model was [MD -2.78 (95%CI, -3.48, -2.07)] in 13 self-controlled studies. Outcomes on O’Leary-Sant Interstitial Cystitis Symptom Index, Problem Index, frequency, urgency, and bladder capacity were also significantly improved. Subgroup analysis showed significant difference between HA, CS, and the combination, and the perfusion of HA was more effective (Z = 29.97, P < 0.01). Also, different follow-up times after last treatment showed significant difference (Z = 7.69, P < 0.01). It can be beneficial for IC/BPS patients who have not responded to conventional treatments.

Place, publisher, year, edition, pages
Insights Publisher, 2021
Keywords
Interstitial cystitis, Bladder pain syndrome, Chondroitin sulfate, Hyaluronic acid, Meta-analysis
National Category
Urology and Nephrology
Identifiers
urn:nbn:se:umu:diva-190565 (URN)10.15354/si.21.re266 (DOI)
Available from: 2021-12-19 Created: 2021-12-19 Last updated: 2021-12-21Bibliographically approved
Lu, X., Wu, J., Qin, Y., Liang, J., Qian, H., Song, J., . . . Liu, R. (2021). Identification of N-glycoproteins of hip cartilage in patients with osteonecrosis of femoral head using quantitative glycoproteomics. International Journal of Biological Macromolecules, 187, 892-902
Open this publication in new window or tab >>Identification of N-glycoproteins of hip cartilage in patients with osteonecrosis of femoral head using quantitative glycoproteomics
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2021 (English)In: International Journal of Biological Macromolecules, ISSN 0141-8130, E-ISSN 1879-0003, Vol. 187, p. 892-902Article in journal (Refereed) Published
Abstract [en]

N-glycosylation is a major post-translational modification of proteins and involved in many diseases, however, the state and role of N-glycosylation in cartilage degeneration of osteonecrosis of femoral head (ONFH) remain unclear. The aim of this study is to identify the glycoproteins of ONFH hip cartilage. Cartilage tissues were collected from nine patients with ONFH and nine individuals with traumatic femoral neck fracture. Cartilage glycoproteins were identified by glycoproteomics based on LC-MS/MS. The differentially N-glycoproteins including glycosites were identified in ONFH and controls. A total of 408 N-glycoproteins with 444 N-glycosites were identified in ONFH and control cartilage. Among them, 104 N-glycoproteins with 130 N-glycosites were significantly differential in ONFH and control cartilage, which including matrix-remodeling-associated protein 5, prolow-density lipoprotein receptor-related protein 1, clusterin and lysosome-associated membrane glycoprotein 2. Gene Ontology analysis revealed the significantly differential glycoproteins mainly belonged to protein metabolic process, single-multicellular organism process, proteolysis, biological adhesion and cell adhesion. KEGG pathway and protein-protein interaction analysis suggested that the significantly differential glycoproteins were associated with PI3K-Akt signalling pathway, ECM-receptor interaction, protein processing in the endoplasmic reticulum and N-glycan biosynthesis. This information provides substantial insight into the role of protein glycosylation in the development of cartilage degeneration of ONFH patients.

Place, publisher, year, edition, pages
Elsevier, 2021
Keywords
Osteonecrosis of femoral head, Cartilage degeneration, Glycoproteomics, LC-MS/MS, Protein glycosylation
National Category
Orthopaedics Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-186700 (URN)10.1016/j.ijbiomac.2021.07.159 (DOI)000691599600001 ()34331982 (PubMedID)2-s2.0-85112488977 (Scopus ID)
Available from: 2021-08-18 Created: 2021-08-18 Last updated: 2023-09-05Bibliographically approved
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Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-1710-7715

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