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Kovacs, A. H., Luyckx, K., Thomet, C., Budts, W., Enomoto, J., Sluman, M. A., . . . Moons, P. (2024). Anxiety and depression in adults with congenital heart disease. Journal of the American College of Cardiology, 83(3), 430-441
Open this publication in new window or tab >>Anxiety and depression in adults with congenital heart disease
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2024 (English)In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 83, no 3, p. 430-441Article in journal (Refereed) Published
Abstract [en]

Background: A comprehensive understanding of adult congenital heart disease outcomes must include psychological functioning. Our multisite study offered the opportunity to explore depression and anxiety symptoms within a global sample.

Objectives: In this substudy of the APPROACH-IS (Assessment of Patterns of Patient-Reported Outcomes in Adults With Congenital Heart Disease–International Study), the authors we investigated the prevalence of elevated depression and anxiety symptoms, explored associated sociodemographic and medical factors, and examined how quality of life (QOL) and health status (HS) differ according to the degree of psychological symptoms.

Methods: Participants completed the Hospital Anxiety and Depression Scale, which includes subscales for symptoms of anxiety (HADS-A) and depression (HADS-D). Subscale scores of 8 or higher indicate clinically elevated symptoms and can be further categorized as mild, moderate, or severe. Participants also completed analogue scales on a scale of 0 to 100 for QOL and HS. Analysis of variance was performed to investigate whether QOL and HS differed by symptom category.

Results: Of 3,815 participants from 15 countries (age 34.8 ± 12.9 years; 52.7% female), 1,148 (30.1%) had elevated symptoms in one or both subscales: elevated HADS-A only (18.3%), elevated HADS-D only (2.9%), or elevations on both subscales (8.9%). Percentages varied among countries. Both QOL and HS decreased in accordance with increasing HADS-A and HADS-D symptom categories (P < 0.001).

Conclusions: In this global sample of adults with congenital heart disease, almost one-third reported elevated symptoms of depression and/or anxiety, which in turn were associated with lower QOL and HS. We strongly advocate for the implementation of strategies to recognize and manage psychological distress in clinical settings. (Patient-Reported Outcomes in Adults With Congenital Heart Disease [APPROACH-IS]; NCT02150603)

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
adult congenital heart disease, anxiety, depression, quality of life
National Category
Nursing Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-219533 (URN)10.1016/j.jacc.2023.10.043 (DOI)2-s2.0-85181800376 (Scopus ID)
Funder
Swedish Heart Lung Foundation, 20130607University of Gothenburg
Available from: 2024-01-16 Created: 2024-01-16 Last updated: 2024-01-16Bibliographically approved
Frykholm, E., Simonsson, E., Levik Sandström, S., Hedlund, M., Holmberg, H., Johansson, B., . . . Rosendahl, E. (2024). Applicability of a supramaximal high-intensity interval training program for older adults previously not engaged in regular exercise: analyses of secondary outcomes from the Umeå HIT Study. Psychology of Sport And Exercise, 73, Article ID 102647.
Open this publication in new window or tab >>Applicability of a supramaximal high-intensity interval training program for older adults previously not engaged in regular exercise: analyses of secondary outcomes from the Umeå HIT Study
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2024 (English)In: Psychology of Sport And Exercise, ISSN 1469-0292, E-ISSN 1878-5476, Vol. 73, article id 102647Article in journal (Refereed) Published
Abstract [en]

This analysis of secondary outcomes investigated the applicability of supramaximal high-intensity interval training (HIT) with individually prescribed external intensity performed on stationary bicycles. Sixty-eight participants with a median (min; max) age of 69 (66; 79), at the time not engaged in regular exercise were randomized to 25 twice-weekly sessions of supramaximal HIT (20-min session with 10 × 6-s intervals) or moderate-intensity training (MIT, 40-min session with 3 × 8-min intervals). The primary aim was outcomes on applicability regarding; adherence to prescribed external interval intensity, participant reported positive and negative events, ratings of perceived exertion (RPE 6–20), and affective state (Feeling Scale, FS -5–5). A secondary aim was to investigate change in exercise-related self-efficacy (Exercise Self-Efficacy Scale) and motivation (Behavioural Regulations in Exercise Questionnaire-2). Total adherence to the prescribed external interval intensity was [median (min; max)] 89 % (56; 100 %) in supramaximal HIT, and 100 % (95; 100 %) in MIT. The supramaximal HIT group reported 60 % of the positive (112 of 186) and 36 % of the negative (52 of 146) events. At the end of the training period, the median (min; max) session RPE was 15 (12; 17) for supramaximal HIT and 14 (9; 15) for MIT. As for FS, the median last within-session rating was 3 (−1; 5) for supramaximal HIT and 3 (1; 5) for MIT. Exercise-related motivation increased (mean difference in Relative Autonomy Index score = 1.54, 95 % CI [0.69; 2.40]), while self-efficacy did not change (mean difference = 0.55, 95 % CI [-0.75; 1.82]), regardless of group. This study provide support for supramaximal HIT in supervised group settings for older adults.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
Feasibility, HIIT, Randomized controlled trial, SIT, Sprint interval training
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:umu:diva-223607 (URN)10.1016/j.psychsport.2024.102647 (DOI)38604572 (PubMedID)2-s2.0-85190305065 (Scopus ID)
Funder
Swedish Research Council, 2017–00912Forte, Swedish Research Council for Health, Working Life and Welfare, 2020–00159The Kamprad Family FoundationThe Dementia Association - The National Association for the Rights of the DementedFoundation for the Memory of Ragnhild and Einar LundströmThe Kempe Foundations
Available from: 2024-05-02 Created: 2024-05-02 Last updated: 2024-05-02Bibliographically approved
Holstad, Y., Johansson, B., Lindqvist, M., Westergren, A., Sundström Poromaa, I., Christersson, C., . . . Bay, A. (2024). Breastfeeding in primiparous women with congenital heart disease: a register study. International Breastfeeding Journal, 19(1), Article ID 19.
Open this publication in new window or tab >>Breastfeeding in primiparous women with congenital heart disease: a register study
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2024 (English)In: International Breastfeeding Journal, E-ISSN 1746-4358, Vol. 19, no 1, article id 19Article in journal (Refereed) Published
Abstract [en]

Background: The number of pregnant women with congenital heart disease (CHD) is rising, and the disease poses increased risks of cardiovascular and obstetric complications during pregnancy, potentially impacting breastfeeding success. This study aimed to investigate breastfeeding in primiparous women with CHD compared to primiparous women without CHD, and to examine potential hindering factors for breastfeeding in women with CHD.

Methods: The data were gathered between 2014 and 2019 and obtained by merging the Swedish Congenital Heart Disease Register (SWEDCON) with the Swedish Pregnancy Register. Primiparous women ≥ 18 years of age with CHD (n = 578) were matched by age and municipality to 3049 women without CHD, giving birth after 22 gestational weeks. Multivariable logistic regression analysis was used to identify factors associated with non-breastfeeding in women with CHD.

Results: Fewer women with CHD breastfed than women without CHD two days (94% vs. 97%, p = 0.001) and four weeks after birth (84% vs. 89%, p = 0.006). When all women were analysed, having CHD was associated with non-breastfeeding at both two days and four weeks after birth. For women with CHD, body mass index (BMI) ≥ 30 (OR 3.1; 95% CI 1.4, 7.3), preterm birth (OR 6.4; 95% CI 2.1, 19.0), self-reported history of psychiatric illness (OR 2.4; 95% CI 1.2, 5.1), small for gestational age (OR 4.2; 95% CI 1.4, 12.2), and New York Heart Association Stages of Heart Failure class II − III (OR 6.0; 95% CI 1.4, 26.7) were associated with non-breastfeeding two days after birth. Four weeks after birth, factors associated with non-breastfeeding were BMI ≥ 30 (OR 4.3; 95% CI 2.1, 9.0), self-reported history of psychiatric illness (OR 2.2; 95% CI 1.2, 4.2), and preterm birth (OR 8.9; 95% CI 2.8, 27.9).

Conclusions: The study shows that most women with CHD breastfeed, however, at a slightly lower proportion compared to women without CHD. In addition, factors related to the heart disease were not associated with non-breastfeeding four weeks after birth. Since preterm birth, BMI ≥ 30, and psychiatric illness are associated with non-breastfeeding, healthcare professionals should provide greater support to women with CHD having these conditions.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2024
National Category
Cardiac and Cardiovascular Systems Nursing
Identifiers
urn:nbn:se:umu:diva-222559 (URN)10.1186/s13006-024-00627-y (DOI)38509505 (PubMedID)2-s2.0-85188251664 (Scopus ID)
Funder
Umeå UniversityNorrländska HjärtfondenSwedish Heart Lung FoundationThe Swedish Heart and Lung Association
Available from: 2024-03-21 Created: 2024-03-21 Last updated: 2024-04-11Bibliographically approved
Daelman, B., Van Bulck, L., Luyckx, K., Kovacs, A. H., Van De Bruaene, A., Ladouceur, M., . . . Wijayarathne, P. M. (2024). Frailty and cognitive function in middle-aged and older adults with congenital heart disease. Journal of the American College of Cardiology, 83(12), 1149-1159
Open this publication in new window or tab >>Frailty and cognitive function in middle-aged and older adults with congenital heart disease
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2024 (English)In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 83, no 12, p. 1149-1159Article in journal (Refereed) Published
Abstract [en]

Background: Life expectancy of patients with congenital heart disease (CHD) has increased rapidly, resulting in a growing and aging population. Recent studies have shown that older people with CHD have higher morbidity, health care use, and mortality. To maintain longevity and quality of life, understanding their evolving medical and psychosocial challenges is essential.

Objectives: The authors describe the frailty and cognitive profile of middle-aged and older adults with CHD to identify predictor variables and to explore the relationship with hospital admissions and outpatient visits.

Methods: Using a cross-sectional, multicentric design, we included 814 patients aged ≥40 years from 11 countries. Frailty phenotype was determined using the Fried method. Cognitive function was assessed by the Montreal Cognitive Assessment.

Results: In this sample, 52.3% of patients were assessed as robust, 41.9% as prefrail, and 5.8% as frail; 38.8% had cognitive dysfunction. Multinomial regression showed that frailty was associated with older age, female sex, higher physiologic class, and comorbidities. Counterintuitively, patients with mild heart defects were more likely than those with complex lesions to be prefrail. Patients from middle-income countries displayed more prefrailty than those from higher-income countries. Logistic regression demonstrated that cognitive dysfunction was related to older age, comorbidities, and lower country-level income.

Conclusions: Approximately one-half of included patients were (pre-)frail, and more than one-third experienced cognitive impairment. Frailty and cognitive dysfunction were identified in patients with mild CHD, indicating that these concerns extend beyond severe CHD. Assessing frailty and cognition routinely could offer valuable insights into this aging population.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
aging, cognition, congenital heart defects, frailty, frailty phenotype
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-222575 (URN)10.1016/j.jacc.2024.01.021 (DOI)38508848 (PubMedID)2-s2.0-85187024075 (Scopus ID)
Funder
Swedish Heart Lung Foundation, 20190525
Available from: 2024-04-08 Created: 2024-04-08 Last updated: 2024-04-08Bibliographically approved
Rinnström, D. & Johansson, B. (2024). New findings on ascending aortic dilation in coarctation of the aorta: expanding perspectives. Journal of the American College of Cardiology, 83(12), 1147-1148
Open this publication in new window or tab >>New findings on ascending aortic dilation in coarctation of the aorta: expanding perspectives
2024 (English)In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 83, no 12, p. 1147-1148Article in journal, Editorial material (Other academic) Published
Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
bicuspid aortic valve, coarctation of aorta, thoracic aorta aneurysms
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-222432 (URN)10.1016/j.jacc.2024.02.011 (DOI)2-s2.0-85187014332 (Scopus ID)
Available from: 2024-03-19 Created: 2024-03-19 Last updated: 2024-03-19Bibliographically approved
Bay, A., Berghammer, M., Burström, Å., Holstad, Y., Christersson, C., Dellborg, M., . . . Johansson, B. (2024). Symptoms during pregnancy in primiparous women with congenital heart disease. Scandinavian Cardiovascular Journal, 58(1), Article ID 2302135.
Open this publication in new window or tab >>Symptoms during pregnancy in primiparous women with congenital heart disease
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2024 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 58, no 1, article id 2302135Article in journal (Refereed) Published
Abstract [en]

Background: As more women with congenital heart disease (CHD) are reaching childbearing age, it becomes more common for their symptoms to be evaluated during pregnancy. However, pregnancy-related symptoms are similar to those caused by heart disease. This study investigated the prevalence of factors associated with symptoms during pregnancy in women with CHD.

Methods: The national birth register was searched for primiparous women with CHD who were registered in the national quality register for patients with CHD.

Results: Symptoms during the third trimester were reported in 104 of 465 evaluated women. The most common symptom was palpitations followed by dyspnea. Factors associated with symptoms were tested in a univariable model; higher NYHA classification (>1) (OR 11.3, 95%CI 5.5–23.2), low physical activity (≤3 h/week) (OR 2.1 95%CI 1.3–3.6) and educational level ≤ 12 years (OR 1.9 95%CI 1.2–3.0) were associated with having symptoms. In multivariable analysis, low physical activity level (OR 2.4 95%CI 1.2–5.0) and higher NYHA class (OR 11.3 95%CI 5.0–25.6) remained associated with symptoms during pregnancy. There were no cases with new onset of impaired systemic ventricular function during pregnancy.

Conclusion: Symptoms during pregnancy are common in women with CHD but are often already present before pregnancy. Because ordinary symptoms during pregnancy often overlap with symptoms of heart disease, it is important to know if symptoms were present before pregnancy and if they became worse during pregnancy. These results should be included in pre-pregnancy counselling and considered in the monitoring during pregnancy.

Place, publisher, year, edition, pages
Taylor & Francis, 2024
Keywords
Congenital heart disease, pregnancy, pregnancy symptoms, reproductive health
National Category
Nursing
Identifiers
urn:nbn:se:umu:diva-219523 (URN)10.1080/14017431.2024.2302135 (DOI)2-s2.0-85181968010 (Scopus ID)
Funder
Swedish Heart Lung FoundationThe Swedish Heart and Lung Association
Available from: 2024-01-22 Created: 2024-01-22 Last updated: 2024-01-22Bibliographically approved
Jonsson, S., Sundström-Poromaa, I., Johansson, B., Alenius Dahlqvist, J., Christersson, C., Dellborg, M., . . . Bay, A. (2024). Time to childbirth and assisted reproductive treatment in women with congenital heart disease. Open heart, 11(1), Article ID e002591.
Open this publication in new window or tab >>Time to childbirth and assisted reproductive treatment in women with congenital heart disease
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2024 (English)In: Open heart, E-ISSN 2053-3624, Vol. 11, no 1, article id e002591Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate the time to first childbirth and to compare the prevalence of assisted reproductive treatment (ART) in women with congenital heart disease (CHD) compared with women without CHD.

Methods: All women in the national register for CHD who had a registered first childbirth in the Swedish Pregnancy Register between 2014 and 2019 were identified. These individuals (cases) were matched by birth year and municipality to women without CHD (controls) in a 1:5 ratio. The time from the 18th birthday to the first childbirth and the prevalence of ART was compared between cases and controls.

Results: 830 first childbirths in cases were identified and compared with 4137 controls. Cases were slightly older at the time for first childbirth (28.9 vs 28.5 years, p=0.04) and ART was more common (6.1% vs 4.0%, p<0.01) compared with controls. There were no differences in ART when stratifying for the complexity of CHD. For all women, higher age was associated with ART treatment (OR 1.24, 95% CI 1.20 to 1.28).

Conclusions: Women with and without CHD who gave birth to a first child did so at similar ages. ART was more common in women with CHD, but disease severity did not influence the need for ART. Age was an important risk factor for ART also in women with CHD and should be considered in consultations with these patients.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2024
National Category
Nursing Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:umu:diva-222406 (URN)10.1136/openhrt-2023-002591 (DOI)001186478600001 ()38485120 (PubMedID)2-s2.0-85188018449 (Scopus ID)
Funder
Swedish Heart Lung FoundationThe Swedish Heart and Lung Association
Available from: 2024-03-17 Created: 2024-03-17 Last updated: 2024-04-22Bibliographically approved
Hansén, N., Ljungberg, J., Bergdahl, I., Hultdin, J., Näslund, U., Johansson, B. & Söderberg, S. (2023). Adipokines are possible risk markers for aortic stenosis requiring surgery. Scandinavian Cardiovascular Journal, 57(1), Article ID 2247193.
Open this publication in new window or tab >>Adipokines are possible risk markers for aortic stenosis requiring surgery
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2023 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 57, no 1, article id 2247193Article in journal (Refereed) Published
Abstract [en]

Objectives: Aortic stenosis (AS) is the most prevalent valvular heart disease among adults. The adipocyte-derived hormones, leptin and adiponectin, have profound metabolic actions. We examined whether these adipokines are independently associated with future aortic valve replacement (AVR).

Design: In this longitudinal case-control study, we identified 336 cases who had undergone AVR due to AS, and who had previously participated in population-based health surveys. Two referents were matched to each case and leptin and adiponectin concentrations were analysed from stored baseline survey samples. Uni- and multivariable logistic regression analyses were used to estimate the risk of future AVR. An additional cohort was identified for validation including 106 cases with AVR and 212 matched referents.

Results: Median age (interquartile range (IQR)) in years at survey was 59.9 (10.4) and at surgery 68.3 (12.7), and 48% were women. An elevated concentration of leptin was not associated with future AVR (odds ratio [95% confidence interval]) (1.10 [0.92–1.32]), although leptin was associated with a higher risk in patients with coronary artery disease (CAD) having more than 5 years between survey and AVR (1.41 [1.08–1.84]). Adiponectin was not associated with higher risk for future AVR (0.95 [0.82–1.11]), although after stratification for age, higher levels were associated with reduced risk for AVR in persons aged ≥60 years at surgery (0.79 [0.64–0.98]). In the validation study, leptin was associated with future AVR whereas adiponectin was not. None of the associations remained significant after adjustment for body mass index (BMI).

Conclusions: The adipokine leptin may promote the development of AS.

Place, publisher, year, edition, pages
Taylor & Francis, 2023
Keywords
adiponectin, Aortic stenosis, fat mass, leptin, prospective study, risk markers
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-214075 (URN)10.1080/14017431.2023.2247193 (DOI)001050266400001 ()37592808 (PubMedID)2-s2.0-85168287214 (Scopus ID)
Funder
Swedish Heart Lung Foundation, 20100635Swedish Heart Lung Foundation, 20120631Swedish Heart Lung Foundation, 20140799Swedish Heart Lung Foundation, 20130630Region Västerbotten, RV-967561Umeå University, 964731
Available from: 2023-09-04 Created: 2023-09-04 Last updated: 2023-09-04Bibliographically approved
Yu Chen, H., Dina, C., Small, A. M., Shaffer, C. M., Levinson, R. T., Helgadóttir, A., . . . Thanassoulis, G. (2023). Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study. European Heart Journal, 44(21), 1927-1939
Open this publication in new window or tab >>Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study
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2023 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 44, no 21, p. 1927-1939Article in journal (Refereed) Published
Abstract [en]

AIMS: Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS. METHODS AND RESULTS: A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European ancestry participants (13 765 cases) was performed. Seventeen loci were associated with AS at P ≤ 5 × 10-8, of which 15 replicated in an independent cohort of 90 828 participants (7111 cases), including CELSR2-SORT1, NLRP6, and SMC2. A genetic risk score comprised of the index variants was associated with AS [odds ratio (OR) per standard deviation, 1.31; 95% confidence interval (CI), 1.26-1.35; P = 2.7 × 10-51] and aortic valve calcium (OR per standard deviation, 1.22; 95% CI, 1.08-1.37; P = 1.4 × 10-3), after adjustment for known risk factors. A phenome-wide association study indicated multiple associations with coronary artery disease, apolipoprotein B, and triglycerides. Mendelian randomization supported a causal role for apolipoprotein B-containing lipoprotein particles in AS (OR per g/L of apolipoprotein B, 3.85; 95% CI, 2.90-5.12; P = 2.1 × 10-20) and replicated previous findings of causality for lipoprotein(a) (OR per natural logarithm, 1.20; 95% CI, 1.17-1.23; P = 4.8 × 10-73) and body mass index (OR per kg/m2, 1.07; 95% CI, 1.05-1.9; P = 1.9 × 10-12). Colocalization analyses using the GTEx database identified a role for differential expression of the genes LPA, SORT1, ACTR2, NOTCH4, IL6R, and FADS. CONCLUSION: Dyslipidemia, inflammation, calcification, and adiposity play important roles in the etiology of AS, implicating novel treatments and prevention strategies.

Place, publisher, year, edition, pages
Oxford University Press, 2023
Keywords
Aortic stenosis, Gene expression, Genetic risk score, Genome-wide association study, Mendelian randomization, Phenome-wide association study
National Category
Cardiac and Cardiovascular Systems Medical Genetics
Identifiers
urn:nbn:se:umu:diva-209555 (URN)10.1093/eurheartj/ehad142 (DOI)000989753300001 ()37038246 (PubMedID)2-s2.0-85160838840 (Scopus ID)
Funder
Swedish Heart Lung Foundation, 20140799Swedish Heart Lung Foundation, 20120631Swedish Heart Lung Foundation, 20100635Region Västerbotten, VLL-548791Swedish Heart Lung Foundation, 2016-0134Swedish Heart Lung Foundation, 2016-0315Swedish Heart Lung Foundation, 2019-0526Swedish Research Council, 2017-02554Knut and Alice Wallenberg FoundationSwedish Research Council, 349-2006-237Swedish Foundation for Strategic Research, IRC15-0067NIH (National Institutes of Health), R01 HL128550NordForsk, 90580
Available from: 2023-06-12 Created: 2023-06-12 Last updated: 2023-09-05Bibliographically approved
Simonsson, E., Levik Sandström, S., Hedlund, M., Holmberg, H., Johansson, B., Lindelöf, N., . . . Rosendahl, E. (2023). Effects of controlled supramaximal high-intensity interval training on cardiorespiratory fitness and global cognitive function in older adults: the Umeå hit study-a randomized controlled trial. The journals of gerontology. Series A, Biological sciences and medical sciences, 78(9), 1581-1590
Open this publication in new window or tab >>Effects of controlled supramaximal high-intensity interval training on cardiorespiratory fitness and global cognitive function in older adults: the Umeå hit study-a randomized controlled trial
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2023 (English)In: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 78, no 9, p. 1581-1590Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: This study examined the effects of regulated and controlled supramaximal high-intensity interval training (HIT) adapted for older adults, compared to moderate-intensity training (MIT), on cardiorespiratory fitness; cognitive, cardiovascular, and muscular function; and quality of life.

METHODS: Sixty-eight nonexercising older adults (66-79 years, 44% males) were randomized to 3 months of twice-weekly HIT (20-minute session including 10 × 6-second intervals) or MIT (40-minute session including 3 × 8-minute intervals) on stationary bicycles in an ordinary gym setting. Individualized target intensity was watt controlled with a standardized pedaling cadence and individual adjustment of the resistance load. Primary outcomes were cardiorespiratory fitness (V̇o2peak) and global cognitive function (unit-weighted composite).

RESULTS: V̇o2peak increased significantly (mean 1.38 mL/kg/min, 95% CI [0.77, 1.98]), with no between-group difference (mean difference 0.05 [-1.17, 1.25]). Global cognition did not improve (0.02 [-0.05, 0.09]), nor differed between groups (0.11 [-0.03, 0.24]). Significant between-group differences in change were observed for working memory (0.32 [0.01, 0.64]), and maximal isometric knee extensor muscle strength (0.07 N·m/kg [0.003, 0.137]), both in favor of HIT. Irrespective of the group, there was a negative change in episodic memory (-0.15 [-0.28, -0.02]), a positive change in visuospatial ability (0.26 [0.08, 0.44]), and a decrease in systolic (-2.09 mmHg [-3.54, -0.64]) and diastolic (-1.27 mmHg [-2.31, -0.25]) blood pressure.

CONCLUSIONS: In nonexercising older adults, 3 months of watt-controlled supramaximal HIT improved cardiorespiratory fitness and cardiovascular function to a similar extent as MIT, despite half the training time. In favor of HIT, there was an improvement in muscular function and a potential domain-specific effect on working memory.

CLINICAL TRIAL REGISTRATION: NCT03765385.

Place, publisher, year, edition, pages
Oxford University Press, 2023
Keywords
Aerobic capacity, HIIT, Moderate-intensity training, SIT, Sprint interval training
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:umu:diva-214207 (URN)10.1093/gerona/glad070 (DOI)000959356800001 ()36972981 (PubMedID)2-s2.0-85169177109 (Scopus ID)
Funder
Swedish Research Council, 2017-00912Forte, Swedish Research Council for Health, Working Life and Welfare, 2020-00159The Kamprad Family FoundationThe Dementia Association - The National Association for the Rights of the DementedFoundation for the Memory of Ragnhild and Einar LundströmThe Kempe FoundationsUmeå University
Available from: 2023-09-08 Created: 2023-09-08 Last updated: 2023-09-08Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0003-0976-6910

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