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Domellöf, Magnus
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Publications (10 of 129) Show all publications
Berglund, S. K., Chmielewska, A., Starnberg, J., Westrup, B., Hägglöf, B., Norman, M. & Domellöf, M. (2018). Effects of iron supplementation of low-birth-weight infants on cognition and behavior at 7 years: a randomized controlled trial. Pediatric Research, 83, 111-118
Open this publication in new window or tab >>Effects of iron supplementation of low-birth-weight infants on cognition and behavior at 7 years: a randomized controlled trial
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2018 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 83, p. 111-118Article in journal (Refereed) Published
Abstract [en]

Background Low-birth-weight infants (LBW) are at an increased risk of iron deficiency that has been associated with impaired neurodevelopment. We hypothesized that iron supplementation of LBW infants improves cognitive scores and reduces behavioral problems until school age.

Methods We randomized 285 marginally LBW (2,000-2,500 g) infants to receive 0, 1, or 2 mg/kg/day of iron supplements from 6 weeks to 6 months of age. At 7 years of age, 205 participants were assessed regarding cognition using Wechsler Intelligence Scale for Children (WISC-IV) and behavior using the parental questionnaires Child Behavior Checklist (CBCL) and Five to Fifteen (FTF).

Results There were no significant differences between the intervention groups in WISC-IV or FTF. However, the CBCL scores for externalizing problems were significantly different, in favor of supplemented children (P=0.045). When combining the supplemented groups, they had significantly lower scores for externalizing behavior compared with placebo (median (interquartile range): 44 [34;51] vs. 48.5 [41;56] P=0.013), and their risk ratio (95% confidence interval) for a total behavioral score above the cutoff for clinical problems was 0.31 (0.09-1.0), P=0.054.

Conclusion Lower scores of externalizing behavior in supplemented children support our previous findings at 3 years, and suggest that iron supplementation may have long-lasting effects on behavioral functions.

Place, publisher, year, edition, pages
New York: Nature Publishing Group, 2018
Keywords
weeks gestational age, children born, late preterm, deficiency anemia, brain, growth, childhood, disorder, outcomes, risk
National Category
Pediatrics
Identifiers
urn:nbn:se:umu:diva-145099 (URN)10.1038/pr.2017.235 (DOI)000426175900019 ()28953856 (PubMedID)
Available from: 2018-02-21 Created: 2018-02-21 Last updated: 2018-11-13Bibliographically approved
Mihatsch, W. A., Braegger, C., Bronsky, J., Cai, W., Campoy, C., Carnielli, V., . . . Yan, W. (2018). ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition. Clinical Nutrition, 37(6), 2303-2305
Open this publication in new window or tab >>ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition
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2018 (English)In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 37, no 6, p. 2303-2305Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Churchill Livingstone, 2018
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-155227 (URN)10.1016/j.clnu.2018.05.029 (DOI)000454376500001 ()30471662 (PubMedID)
Note

Part: B

Available from: 2019-01-14 Created: 2019-01-14 Last updated: 2019-01-14Bibliographically approved
Domellöf, M., Szitanyi, P., Simchowitz, V., Franz, A. & Mimouni, F. (2018). ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Iron and trace minerals. Clinical Nutrition, 37(6), 2354-2359
Open this publication in new window or tab >>ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Iron and trace minerals
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2018 (English)In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 37, no 6, p. 2354-2359Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Churchill Livingstone, 2018
Keywords
Parenteral Nutrition, Infusions, Parenteral, Trace Elements, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Selenium, Zinc
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-155368 (URN)10.1016/j.clnu.2018.06.949 (DOI)000454376500008 ()30078716 (PubMedID)
Note

Part: B

Available from: 2019-01-14 Created: 2019-01-14 Last updated: 2019-01-14Bibliographically approved
Zamir, I., Tornevi, A., Abrahamsson, T., Ahlsson, F., Engström, E., Hallberg, B., . . . Domellöf, M. (2018). Hyperglycemia in extremely preterm infants: insulin treatment, mortality and nutrient intakes. Journal of Pediatrics, 200, 104-110
Open this publication in new window or tab >>Hyperglycemia in extremely preterm infants: insulin treatment, mortality and nutrient intakes
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2018 (English)In: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 200, p. 104-110Article in journal (Refereed) Published
Abstract [en]

Objective: To explore the prevalence of hyperglycemia and the associations between nutritional intakes, hyperglycemia, insulin treatment, and mortality in extremely preterm infants.

Study design: Prospectively collected data from the Extremely Preterm Infants in Sweden Study (EXPRESS) was used in this study and included 580 infants born <27 gestational weeks during 2004-2007. Available glucose measurements (n = 9850) as well as insulin treatment and nutritional data were obtained retrospectively from hospital records for the first 28 postnatal days as well as 28- and 70-day mortality data.

Results: Daily prevalence of hyperglycemia >180 mg/dL (10 mmol/L) of up to 30% was observed during the first 2 postnatal weeks, followed by a slow decrease in its occurrence thereafter. Generalized additive model analysis showed that increasing parenteral carbohydrate supply with 1 g/kg/day was associated with a 1.6% increase in glucose concentration (P < .001). Hyperglycemia was associated with more than double the 28-day mortality risk (P < .01). In a logistic regression model, insulin treatment was associated with lower 28- and 70-day mortality when given to infants with hyperglycemia irrespective of the duration of the hyperglycemic episode (P < .05).

Conclusions: Hyperglycemia is common in extremely preterm infants throughout the first postnatal month. Glucose infusions seem to have only a minimal impact on glucose concentrations. In the EXPRESS cohort, insulin treatment was associated with lower mortality in infants with hyperglycemia. Current practices of hyperglycemia treatment in extremely preterm infants should be reevaluated and assessed in randomized controlled clinical trials.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
neonatology, nutrition
National Category
Pediatrics
Research subject
Pediatrics
Identifiers
urn:nbn:se:umu:diva-146880 (URN)10.1016/j.jpeds.2018.03.049 (DOI)2-s2.0-85046719751 (Scopus ID)
Available from: 2018-04-20 Created: 2018-04-20 Last updated: 2018-10-10Bibliographically approved
Westin, V., Klevebro, S., Domellöf, M., Vanpée, M., Hallberg, B. & Stoltz Sjöström, E. (2018). Improved nutrition for extremely preterm infants: a population based observational study. Clinical Nutrition ESPEN, 23, 245-251
Open this publication in new window or tab >>Improved nutrition for extremely preterm infants: a population based observational study
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2018 (English)In: Clinical Nutrition ESPEN, ISSN 2405-4577, Vol. 23, p. 245-251Article in journal (Refereed) Published
Abstract [en]

Background and aims Extremely preterm (EPT) infants are at high risk for malnutrition due to immaturity and medical complications and they often accumulate nutritional deficits and experience growth faltering during treatment at neonatal intensive care units (NICUs). Enhanced intake of energy and protein during the first weeks of life improves weight gain and head circumference growth. The optimal nutritional strategy for these infants' health and long-term development remains unknown. Nutritional regiments have been identified as a potential area for improvement in Swedish NICUs. The aim of this study was to evaluate changes in nutritional intake over time during the first 56 postnatal days in EPT (<27 gestational weeks; n = 316) infants, who were treated in NICUs during 2004–2011 in Stockholm, using a population-based study approach.

Methods Several different nutritional interventions were implemented over the 8-year period. Nutrition and growth data were obtained retrospectively from hospital records. All intakes of enteral and parenteral nutrients were retrieved daily during the first 28 postnatal days and on days 35, 42, 49 and 56.

Results Energy intake (median) increased from 77 kcal/kg/d during the 2004–2005 period to 98 kcal/kg/d during the 2010–2011 period on days 4–6. Median protein intake increased from 2.4 g/kg/d during 2004–2005 to 3.6 g/kg/d during 2010–2011. Energy and protein intake during postnatal days 0–6 increased continuously over the 8 years and protein intake increased during all 56 postnatal days. Full enteral feeds were reached earlier and the proportion of enteral feeds during the first week was higher during 2008–2009 compared to all other years. A significant improvement in growth was primarily noted by comparing the 2004–2005 period to subsequent years.

Conclusions Neonatal nutrition improved significantly in Stockholm from 2004 to 2011. Above all, parenteral nutrition was initiated more promptly during the first week and was provided at higher quantities. However, many of the EPT infants born during the later years still did not reach the recommended macronutrient intake levels. A significant weight gain improvement was observed between 2004–2005 and 2006–2011.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Enteral nutrition, energy, parenteral nutrition, preterm infant, protein
National Category
Pediatrics Nutrition and Dietetics
Research subject
Pediatrics
Identifiers
urn:nbn:se:umu:diva-140687 (URN)10.1016/j.clnesp.2017.09.004 (DOI)000444125800038 ()
Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2018-10-01Bibliographically approved
Thunqvist, P., Tufvesson, E., Bjermer, L., Winberg, A., Fellman, V., Domellöf, M., . . . Hallberg, J. (2018). Lung function after extremely preterm birthA population-based cohort study (EXPRESS). Pediatric Pulmonology, 53(1), 64-72
Open this publication in new window or tab >>Lung function after extremely preterm birthA population-based cohort study (EXPRESS)
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2018 (English)In: Pediatric Pulmonology, ISSN 8755-6863, E-ISSN 1099-0496, Vol. 53, no 1, p. 64-72Article in journal (Refereed) Published
Abstract [en]

Background and objectives: Follow-up studies of children and young adults born very-to-moderately preterm show persistent and significant lung function deficits. The aim of the study was to determine lung function and airway mechanics in school-aged children born in 2004 to 2007 and extremely preterm (after 22-26 weeks of gestation).

Methods: In a population-based cohort of children born extremely preterm and controls born at term (n=350), follow-up at 61/2-years-of-age was performed using spirometry and impulse oscillometry. Associations to gestational age, smallness for gestational age (SGA), and bronchopulmonary dysplasia (BPD) were assessed.

Results: Children born extremely preterm had lower forced vital capacity (FVC, z-score: -0.7, 95%CI: -1.0;-0.4), forced expiratory volume (FEV1, z-score: -1.1, 95%CI: -1.4; -0.8), higher frequency-dependence of resistance (R5-20, 0.09, 95%CI: 0.05; 0.12 kPaL(-1)s(-1)) and larger area under the reactance curve (AX, 0.78, 95%CI: 0.49; 1.07kPaL(-1)) than controls. In children born at 22-24 weeks of gestation, 24% had FVC and 44% had FEV1 below the lower limit of normal. SGA and severe BPD only marginally contributed to pulmonary outcomes. Asthma-like disease was reported in 40% of extremely preterm children and 15% of controls.

Conclusion: Many children born extremely preterm have altered airway mechanics and significant obstructive reduction in lung function. This warrants consideration for treatment and continued follow-up.

Place, publisher, year, edition, pages
WILEY, 2018
Keywords
lung function tests, preterm birth, respiratory mechanics
National Category
Respiratory Medicine and Allergy Pediatrics
Identifiers
urn:nbn:se:umu:diva-143630 (URN)10.1002/ppul.23919 (DOI)000418247800013 ()29152899 (PubMedID)
Available from: 2018-01-29 Created: 2018-01-29 Last updated: 2018-06-09Bibliographically approved
Lofving, A., Domellöf, M., Hellstrom-Westas, L. & Andersson, O. (2018). Reference intervals for reticulocyte hemoglobin content in healthy infants. Pediatric Research, 84(5), 657-661
Open this publication in new window or tab >>Reference intervals for reticulocyte hemoglobin content in healthy infants
2018 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 84, no 5, p. 657-661Article in journal (Refereed) Published
Abstract [en]

Objectives: Iron deficiency anemia in childhood is a serious public health problem worldwide. Reticulocyte hemoglobin content (Ret-He) is a novel biomarker of iron deficiency adopted for adults but there is a lack of reference intervals for Ret-He in infants. The aim of this study was to provide data from healthy infants.

Methods: Swedish infants (n = 456), born at term after normal pregnancies were included. Ret-He was measured at birth (umbilical cord sample), 48–72 h, 4 months, and 12 months. Reference intervals were calculated as ±2 standard deviations from the mean of Ret-He.

Results: Reference intervals for newborn Ret-He were 27.4 to 36.0 pg/L (N = 376) in the cord sample, 28.1–37.7 pg/L (N = 253) at 48–72 h, 25.6–33.4 pg/L (N = 341) at four months and 24.9–34.1 pg/L (N = 288) at 12 months. Ret-He was significantly lower among iron-deficient infants, at 4 months mean difference (95% CI) −4.2 pg/L (−6.1 to −2.4) and at 12 months mean difference (95% CI) −3.4 pg/L (−5.0 to −1.8).

Conclusions: This longitudinal study presents Ret-He reference intervals based on non-anemic and non-iron-deficient infants and constitutes a step towards standardizing Ret-He as a pre-anemia biomarker of iron deficiency in children.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018
National Category
Pediatrics
Identifiers
urn:nbn:se:umu:diva-155118 (URN)10.1038/s41390-018-0046-4 (DOI)000453019100021 ()30140071 (PubMedID)
Available from: 2019-01-08 Created: 2019-01-08 Last updated: 2019-01-08Bibliographically approved
Fidler Mis, N., Braegger, C., Bronsky, Z., Campoy, C., Domellöf, M., Embleton, N. D., . . . Fewtrell, M. (2018). Response to Letter: How Much Free Sugars Intake Should Be Recommended for Children Younger Than 2 Years Old? [Letter to the editor]. Journal of Pediatric Gastroenterology and Nutrition - JPGN, 66(3), E87-E88
Open this publication in new window or tab >>Response to Letter: How Much Free Sugars Intake Should Be Recommended for Children Younger Than 2 Years Old?
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2018 (English)In: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 66, no 3, p. E87-E88Article in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2018
National Category
Nutrition and Dietetics Gastroenterology and Hepatology Pediatrics
Identifiers
urn:nbn:se:umu:diva-147360 (URN)10.1097/MPG.0000000000001803 (DOI)000429814300011 ()29470324 (PubMedID)
Available from: 2018-05-07 Created: 2018-05-07 Last updated: 2018-06-09Bibliographically approved
Manousou, S., Johansson, B., Chmielewska, A., Eriksson, J., Gutefeldt, K., Tornhage, C.-J., . . . Nyström Filipsson, H. (2018). Role of iodine-containing multivitamins during pregnancy for children’s brain function: protocol of an ongoing randomised controlled trial: the SWIDDICH study. BMJ Open, 8(4), Article ID e019945.
Open this publication in new window or tab >>Role of iodine-containing multivitamins during pregnancy for children’s brain function: protocol of an ongoing randomised controlled trial: the SWIDDICH study
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2018 (English)In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 8, no 4, article id e019945Article in journal (Refereed) Published
Abstract [en]

Introduction: Iodine is essential for normal brain development. Moderate and severe fetal iodine deficiency results in substantial to serious developmental delay in children. Mild iodine deficiency in pregnancy is associated with neurodevelopmental deficits in the offspring, but evidence from randomised trials is lacking. The aim of the Swedish Iodine in Pregnancy and Development in Children study is to determine the effect of daily supplementation with 150 µg iodine during pregnancy on the offspring’s neuropsychological development up to 14 years of age.

Methods and analysis: Thyroid healthy pregnant women (n=1275: age range 18–40 years) at ≤12 weeks gestation will be randomly assigned to receive multivitamin supplements containing 150 µg iodine or non-iodine-containing multivitamin daily throughout pregnancy. As a primary outcome, IQ will be measured in the offspring at 7 years (Wechsler Intelligence Scale for Children-V). As secondary outcomes, IQ will be measured at 3.5 and 14 years, psychomotor development at 18 months and 7 years, and behaviour at 3.5, 7 and 14 years. Iodine status (urinary iodine concentration) will be measured during pregnancy and in the offspring at 3.5, 7 and 14 years. Thyroid function (thyroid hormones, thyroglobulin), and deiodinase type 2 polymorphisms will be measured during pregnancy and in the offspring at 7 and 14 years. Structural MRI or other relevant structural or functional brain imaging procedures will be performed in a subgroup of children at 7 and 14 years. Background and socioeconomic information will be collected at all follow-up times.

Ethics and dissemination: This study is approved by the Ethics Committee in Göteborg, Sweden (Diary numbers: 431-12 approved 18 June 2012 (pregnancy part) and 1089-16 approved 8 February 2017 (children follow-up)). According to Swedish regulations, dietary supplements are governed by the National Food Agency and not by the Medical Product Agency. Therefore, there is no requirement for a monitoring committee and the National Food Agency does not perform any audits of trial conduct. The trial will be conducted in accordance with the Declaration of Helsinki. The participating sites will be contacted regarding important protocol changes, both orally and in writing, and the trial registry database will be updated accordingly. Study results will be presented at relevant conferences, and submitted to peer-reviewed journals with open access in the fields of endocrinology, paediatrics and nutrition. After the appropriate embargo period, the results will be communicated to participants, healthcare professionals at the maternal healthcare centres, the public and other relevant groups, such as the national guideline group for thyroid and pregnancy and the National Food Agency.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2018
National Category
Pediatrics
Identifiers
urn:nbn:se:umu:diva-151179 (URN)10.1136/bmjopen-2017-019945 (DOI)000435176700117 ()29643159 (PubMedID)
Available from: 2018-09-05 Created: 2018-09-05 Last updated: 2018-09-05Bibliographically approved
Bruun, S., Gouveia-Figueira, S., Domellöf, M., Husby, S., Jacobsen, L. N., Michaelsen, K. F., . . . Zachariassen, G. (2018). Satiety Factors Oleoylethanolamide, Stearoylethanolamide, and Palmitoylethanolamide in Mother's Milk Are Strongly Associated with Infant Weight at Four Months of Age: data from the Odense Child Cohort. Nutrients, 10(11), Article ID 1747.
Open this publication in new window or tab >>Satiety Factors Oleoylethanolamide, Stearoylethanolamide, and Palmitoylethanolamide in Mother's Milk Are Strongly Associated with Infant Weight at Four Months of Age: data from the Odense Child Cohort
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2018 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 10, no 11, article id 1747Article in journal (Refereed) Published
Abstract [en]

Regulation of appetite and food intake is partly regulated by N-acylethanolamine lipids oleoylethanolamide (OEA), stearoylethanolamide (SEA), and palmitoylethanolamide (PEA), which induce satiety through endogenous formation in the small intestine upon feeding, but also when orally or systemic administered. OEA, SEA, and PEA are present in human milk, and we hypothesized that the content of OEA, SEA, and PEA in mother's milk differed for infants being heavy (high weight-for-age Z-score (WAZ)) or light (low WAZ) at time of milk sample collection. Ultra-high performance liquid chromatography-mass spectrometry was used to determine the concentration of OEA, SEA, and PEA in milk samples collected four months postpartum from mothers to high (n = 50) or low (n = 50) WAZ infants. Associations between OEA, SEA, and PEA concentration and infant anthropometry at four months of age as well as growth from birth were investigated using linear and logistic regression analyses, adjusted for birth weight, early infant formula supplementation, and maternal pre-pregnancy body mass index. Mean OEA, SEA, and PEA concentrations were lower in the high compared to the low WAZ group (all p < 0.02), and a higher concentration of SEA was associated with lower anthropometric measures, e.g., triceps skinfold thickness (mm) (β = -2.235, 95% CI = -4.04, -0.43, p = 0.016), and weight gain per day since birth (g) (β = -8.169, 95% CI = -15.26, -1.08, p = 0.024). This raises the possibility, that the content of satiety factors OEA, SEA, and PEA in human milk may affect infant growth.

Place, publisher, year, edition, pages
MDPI, 2018
Keywords
infant growth, appetite regulation, N-acylethanolamines, OEA, SEA, PEA, breastfeeding, human milk composition, obesity
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-154357 (URN)10.3390/nu10111747 (DOI)000451547700185 ()30428553 (PubMedID)2-s2.0-85056620089 (Scopus ID)
Available from: 2018-12-17 Created: 2018-12-17 Last updated: 2018-12-18Bibliographically approved
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