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Gu, Weigang
Publications (5 of 5) Show all publications
Gu, W. (2016). Thrombectomy versus intravenous thrombolysis for treating acute anterior and posterior circulation stroke. Paper presented at European Stroke Conference. 25th Conference, Venice, Italy, April 13-15, 2016. Cerebrovascular Diseases, 41, 145-145
Open this publication in new window or tab >>Thrombectomy versus intravenous thrombolysis for treating acute anterior and posterior circulation stroke
2016 (English)In: Cerebrovascular Diseases, ISSN 1015-9770, E-ISSN 1421-9786, Vol. 41, p. 145-145Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
S. Karger, 2016
National Category
Neurology Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-124272 (URN)000376023700183 ()
Conference
European Stroke Conference. 25th Conference, Venice, Italy, April 13-15, 2016
Note

E-book: 978-3-318-05885-7

Available from: 2016-08-01 Created: 2016-07-29 Last updated: 2018-06-07Bibliographically approved
Gu, W. & Jonasson, P. (2014). Trombektomi gav gott resultat vid basilaris­trombos: Förlängt tidsfönster för ingreppet föreslås. Läkartidningen, 111(27-28), 1188-1190
Open this publication in new window or tab >>Trombektomi gav gott resultat vid basilaris­trombos: Förlängt tidsfönster för ingreppet föreslås
2014 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 111, no 27-28, p. 1188-1190Article in journal (Refereed) Published
Abstract [sv]

Basilaristrombos är ett akut och livshotande tillstånd. Intravenös trombolys är förstahandsbehandling, men ibland kan det vara en fördel att kombinera eller ersätta behandlingen med trombektomi. 

Lyckade behandlingsresultat med trombektomi finns beskrivna ända upp till 12–24 timmar efter insjuknandet. 

I fallbeskrivningarna diskuteras basilaristrombos hos två patienter som insjuknat med oklar medvetandesänkning. 

DT-angiografi gav diagnosen, och trombektomi kunde utföras 10 respektive 13 timmar efter insjuknandet. Långtidsresultatet var gott. 

Slutsatsen är att DT alltid ska kompletteras med DT-angiografi vid utredning av en akut medvetandepåverkad patient. 

Trombektomi bör övervägas om basilaristrombos påvisas.

Abstract [en]

[Thrombectomy gave good results in basilar thrombosis. Prolonged time window for the intervention is proposed].

Basilar stroke is one of the most devastating acute cerebral vascular events. Intravascular thrombectomy may be performed beyond the 4.5 hours intravenous thrombolysis time window. However, the time window for thrombectomy in basilar stroke remains unclear. In our clinics, two cases of coma of unknown origin were diagnosed through CT angiography as distal basilar occlusion and treated with thromb­ectomy. Recanalization was achieved at 10 hours after stroke onset in case 1 and at 13 hours in case 2. The first patient regained consciousness shortly after operation and walked unlimited at 2 months after stroke. The second patient woke up slowly with cortical blindness, cerebellar ataxia, and unilateral weakness. At 10 months post stroke, he moved unlimited with mRS 2. Therefore, acute brain CT scan should always be accompanied with CT angiography in cases of coma of unknown origin for the differential diagnosis of basilar stroke where thrombectomy may be considered up to 13 hours after stroke onset.

Place, publisher, year, edition, pages
Läkartidningen förlag AB, 2014
National Category
Neurology
Identifiers
urn:nbn:se:umu:diva-98389 (URN)25162109 (PubMedID)
Available from: 2015-01-21 Created: 2015-01-21 Last updated: 2018-06-07Bibliographically approved
Gu, W., Gu, C., Jiang, W. & Wester, P. (2010). Neurotransmitter synthesis in poststroke cortical neurogenesis in adult rats.. Stem cell research, 4(2), 148-154
Open this publication in new window or tab >>Neurotransmitter synthesis in poststroke cortical neurogenesis in adult rats.
2010 (English)In: Stem cell research, ISSN 1876-7753, Vol. 4, no 2, p. 148-154Article in journal (Refereed) Published
Abstract [en]

Neurogenesis occurs in the cerebral cortex of adult rats after focal cerebral ischemia. Whether or not the newborn neurons could synthesize neurotransmitters is unknown. To elucidate such a possibility, a photothrombotic ring stroke model with spontaneous reperfusion was induced in adult male Wistar rats. The DNA duplication marker BrdU was repeatedly injected, and the rats were sacrificed at various times after stroke. To detect BrdU nuclear incorporation and various neurotransmitters, brain sections were processed for single/double immunocytochemistry and single/double/triple immunofluorescence. Stereological cell counting was performed to assess the final cell populations. At 48 h, 5 days, 7 days, 30 days, 60 days and 90 days after stroke, numerous cells were BrdU-immunolabeled in the penumbral cortex. Some of these were doubly immunopositive to the cholinergic neuron-specific marker ChAT or GABAergic neuron-specific marker GAD. As analyzed by 3-D confocal microscopy, the neurotransmitters acetylcholine and GABA were colocalized with BrdU in the same cortical cells. In addition, GABA was colocalized with the neuron-specific marker Neu N in the BrdU triple-immunolabeled cortical cells. This study suggests that the newborn neurons are capable of synthesizing the neurotransmitters acetylcholine and GABA in the penumbral cortex, which is one of the fundamental requisites for these neurons to function in the poststroke recovery.

Place, publisher, year, edition, pages
Elsevier, 2010
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-35682 (URN)10.1016/j.scr.2009.12.001 (DOI)000276297600007 ()20089468 (PubMedID)
Available from: 2010-08-31 Created: 2010-08-31 Last updated: 2018-06-08Bibliographically approved
Gu, W., Brännström, T., Rosqvist, R. & Wester, P. (2009). Cell division in the cerebral cortex of adult rats after photothrombotic ring stroke.. Stem Cell Research, 2(1), 68-77
Open this publication in new window or tab >>Cell division in the cerebral cortex of adult rats after photothrombotic ring stroke.
2009 (English)In: Stem Cell Research, ISSN 1876-7753, Vol. 2, no 1, p. 68-77Article in journal (Refereed) Published
Abstract [en]

Neurogenesis has been shown to occur in the cerebral cortex in adult rats after ischemic stroke. The origin of the newborn neurons is largely unknown. This study aimed to explore cell division in the poststroke penumbral cortex. Adult male Wistar rats were subjected to photothrombotic ring stroke. After repeated delivery of the DNA duplication marker BrdU, the animals were sacrificed at various times poststroke. BrdU was detected by immunohistochemistry/immunofluorescence labeling, as was the M-phase marker Phos H3 and the spindle components alpha-tubulin/gamma-tubulin. DNA damage was examined by TUNEL staining. Cell type was ascertained by double immunolabeling with the neuronal markers Map-2ab/beta-tubulin III and NeuN/Hu or the astrocyte marker GFAP. From 16h poststroke, BrdU-immunolabeled cells appeared in the penumbral cortex. From 24h, Phos H3 was colocalized with BrdU in the nuclei. Mitotic spindles immunolabeled by alpha-tubulin/gamma-tubulin appeared inside the cortical cells containing BrdU-immunopositive nuclei. Unexpectedly, the markers of neuronal differentiation, Map-2ab/beta-tubulin III/NeuN/Hu, were expressed in the Phos H3-immunolabeled cells, and NeuN was detected in some cells containing spindles. This study suggests that in response to a sublethal ischemic insult, endogenous cells with neuronal immunolabeling may duplicate their nuclear DNA and commit cell mitosis to generate daughter neurons in the penumbral cortex in adult rats.

Place, publisher, year, edition, pages
Elsevier, 2009
Keywords
apoptosis, cisplatin, malignant pleural mesothelioma (MPM), phase-contrast microscopy (PCM), scanning electron microscopy (SEM)
National Category
Cell and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-24706 (URN)10.1016/j.scr.2008.07.003 (DOI)19383410 (PubMedID)
Available from: 2009-07-10 Created: 2009-07-10 Last updated: 2018-06-08Bibliographically approved
Hu, X., Brännström, T., Gu, W. & Wester, P. (1999). A photothrombotic ring stroke model in rats with or without late spontaneous reperfusion in the region at risk. Brain Research, 849(1-2), 175-186
Open this publication in new window or tab >>A photothrombotic ring stroke model in rats with or without late spontaneous reperfusion in the region at risk
1999 (English)In: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 849, no 1-2, p. 175-186Article in journal (Refereed) Published
Abstract [en]

This study aimed at developing a dual setup of the photothrombotic ring stroke model with or without late spontaneous reperfusion in the region at risk and to explore the morphological consequences. The exposed crania of adult male Wistar rats were subjected to a ring-shaped laser-irradiation beam (o.d. 5.0 mm, 0.35 mm thick) for 2 min simultaneously with intravenous erythrosin B (17 mg/kg) infusion. Transcardial carbon-black perfusion revealed that a laser intensity of 0.90 W/cm(2) resulted in late, that is, starting at 72 h, spontaneous reperfusion, whereas the lowest laser intensity that produced lack of reperfusion at 7 days post-irradiation was 1.84 W/cm(2). Laser-Doppler flowmetry showed prompt cortical cerebral blood flow (cCBF) reduction both in the ring lesion and region at risk (12% and 25% of control values) after high-intensity irradiation; these reduced flow values were more rapid and pronounced than in the low-intensity irradiation setup as previously shown. The high- compared with low-intensity irradiation setup produced more frequent occurrence of thrombi in the ring-lesion region and a larger ischemic cortical lesion with a more rapid pace of ischemic cellular changes in the ring-lesion region and the region at risk. The region at risk transformed into pannecrosis in the high-intensity, but recovered morphologically in the low-intensity irradiation setup. This dual photothrombotic setup with or without spontaneous reperfusion enables the study of events related to ischemic cell survival or death in an anatomically predefined region at risk.

National Category
Neurosciences
Identifiers
urn:nbn:se:umu:diva-133949 (URN)10.1016/S0006-8993(99)02152-6 (DOI)000084486900019 ()10592300 (PubMedID)2-s2.0-0345008870 (Scopus ID)
Available from: 2017-04-22 Created: 2017-04-22 Last updated: 2019-03-19Bibliographically approved
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