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Olofsson, Mona
Publications (10 of 22) Show all publications
Lindmark, K., Boman, K., Olofsson, M., Törnblom, M., Levine, A., Castelo-Branco, A., . . . Wikström, G. (2019). Epidemiology of heart failure and trends in diagnostic work-up: a retrospective, population-based cohort study in Sweden. Clinical Epidemiology, 11, 231-244
Open this publication in new window or tab >>Epidemiology of heart failure and trends in diagnostic work-up: a retrospective, population-based cohort study in Sweden
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2019 (English)In: Clinical Epidemiology, ISSN 1179-1349, E-ISSN 1179-1349, Vol. 11, p. 231-244Article in journal (Refereed) Published
Abstract [en]

Purpose: The purpose of this study was to examine the trends in heart failure (HF) epidemiology and diagnostic work-up in Sweden.

Methods: Adults with incident HF (>= 2 ICD-10 diagnostic codes) were identified from linked national health registers (cohort 1, 2005-2013) and electronic medical records (cohort 2, 2010-2015; primary/secondary care patients from Uppsala and Vasterbotten). Trends in annual HF incidence rate and prevalence, risk of all-cause and cardiovascular disease (CVD)-related 1-year mortality and use of diagnostic tests 6 months before and after first HF diagnosis (cohort 2) were assessed.

Results: Baseline demographic and clinical characteristics were similar for cohort 1 (N=174,537) and 2 (N=8,702), with mean ages of 77.4 and 76.6 years, respectively; almost 30% of patients were aged >= 85 years. From 2010 to 2014, age-adjusted annual incidence rate of HF/1,000 inhabitants decreased (from 3.20 to 2.91, cohort 1; from 4.34 to 3.33, cohort 2), while age-adjusted prevalence increased (from 1.61% to 1.72% and from 2.15% to 2.18%, respectively). Age-adjusted 1-year all-cause and CVD-related mortality was higher in men than in women among patients in cohort 1 (all-cause mortality hazard ratio [HR] men vs women 1.07 [95% CI 1.06-1.09] and CVD-related mortality subdistribution HR for men vs women 1.04 [95% CI 1.02-1.07], respectively). While 83.5% of patients underwent N-terminal pro-B-type natriuretic peptide testing, only 36.4% of patients had an echocardiogram at the time of diagnosis, although this increased overtime. In the national prevalent HF population (patients with a diagnosis in 1997-2004 who survived into the analysis period; N=273,999), death from ischemic heart disease and myocardial infarction declined between 2005 and 2013, while death from HF and atrial fibrillation/flutter increased (P<0.0001 for trends over time).

Conclusion: The annual incidence rate of HF declined over time, while prevalence of HF has increased, suggesting that patients with HF were surviving longer over time. Our study confirms that previously reported epidemiological trends persist and remain to ensure proper diagnostic evaluation and management of patients with HF.

Place, publisher, year, edition, pages
Dove medical press, 2019
Keywords
diagnosis, heart failure, incidence rate, mortality, prevalence, real-world
National Category
Cardiac and Cardiovascular Systems Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-158769 (URN)10.2147/CLEP.S170873 (DOI)000464038900001 ()30962724 (PubMedID)
Available from: 2019-05-08 Created: 2019-05-08 Last updated: 2019-05-08Bibliographically approved
Olofsson, M., Boman, K., Lindmark, K., Wikstrom, G., Bergman, G. J., Tornblom, M., . . . Stalhammar, J. (2017). A description of characteristics of very elderly patients newly diagnosed with heart failure: a retrospective population-based cohort study in Sweden. European Journal of Heart Failure, 19(Supplement: 1), 362-362, Article ID Meeting Abstract: 1519.
Open this publication in new window or tab >>A description of characteristics of very elderly patients newly diagnosed with heart failure: a retrospective population-based cohort study in Sweden
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2017 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 19, no Supplement: 1, p. 362-362, article id Meeting Abstract: 1519Article in journal, Meeting abstract (Refereed) Published
Place, publisher, year, edition, pages
WILEY, 2017
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-136995 (URN)000401005301176 ()
Available from: 2017-06-29 Created: 2017-06-29 Last updated: 2019-05-21Bibliographically approved
Boman, K., Olofsson, M., Bergman, A.-C. R. & Brännström, M. (2017). Anaemia, but not iron deficiency, is associated with clinical symptoms and quality of life in patients with severe heart failure and palliative home care: a substudy of the PREFER trial. European journal of internal medicine, 46, 35-40
Open this publication in new window or tab >>Anaemia, but not iron deficiency, is associated with clinical symptoms and quality of life in patients with severe heart failure and palliative home care: a substudy of the PREFER trial
2017 (English)In: European journal of internal medicine, ISSN 0953-6205, E-ISSN 1879-0828, Vol. 46, p. 35-40Article in journal (Refereed) Published
Abstract [en]

Background: To explore the relationships between anaemia or iron deficiency (ID) and symptoms, quality of life (QoL), morbidity, and mortality.

Methods: A post-hoc, non-prespecified, explorative substudy of the prospective randomized PREFER trial. One centre study of outpatients with severe HF and palliative need managed with advanced home care. Associations between anaemia, ID, and the Edmonton Symptom Assessment Scale (ESAS), Euro QoL (EQ-5D), Kansas City Cardiomyopathy Questions (KCCQ) were examined only at baseline but at 6months for morbidity and mortality.

Results: Seventy-two patients (51 males, 21 females), aged 79.2±9.1years. Thirty-nine patients (54%) had anaemia and 34 had ID (47%). Anaemia was correlated to depression (r=0.37; p=0.001), anxiety (r=0.25; p=0.04), and reduced well-being (r=0.26; p=0.03) in the ESAS; mobility (r=0.33; p=0.005), pain/discomfort (r=0.27; p=0.02), and visual analogue scale of health state (r=-0.28; p=0.02) in the EQ-5D; and physical limitation (r=-0.27; p=0.02), symptom stability; (r=-0.43; p<0.001); (r=-0.25; p=0.033), social limitation;(r=-0.26; p=0.03), overall summary score; (r=-0.24, p=0.046) and clinical summary score; (r=-0.27; p=0.02) in the KCCQ. ID did not correlate to any assessment item. Anaemia was univariably associated with any hospitalization (OR: 3.0; CI: 1.05-8.50, p=0.04), but not to mortality. ID was not significantly associated with any hospitalization or mortality.

Conclusion: Anaemia, but not ID, was associated although weakly with symptoms and QoL in patients with advanced HF and palliative home care.

Place, publisher, year, edition, pages
Amsterdam: Elsevier, 2017
Keywords
Anaemia, Heart failure, Iron deficiency, Palliative care
National Category
Nursing
Identifiers
urn:nbn:se:umu:diva-139876 (URN)10.1016/j.ejim.2017.08.027 (DOI)000417096400027 ()28899603 (PubMedID)
Available from: 2017-09-25 Created: 2017-09-25 Last updated: 2018-06-09Bibliographically approved
Boman, K., Lindmark, K., Stalhammar, J., Wikstrom, G., Bergman, G. J., Tornblom, M., . . . Olofsson, M. (2017). Costs associated with heart failure with preserved versus reduced ejection fraction: a retrospective population-based cohort study in Sweden. European Journal of Heart Failure, 19(Supplement: 1), 346-347, Article ID Meeting Abstract: 1383.
Open this publication in new window or tab >>Costs associated with heart failure with preserved versus reduced ejection fraction: a retrospective population-based cohort study in Sweden
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2017 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 19, no Supplement: 1, p. 346-347, article id Meeting Abstract: 1383Article in journal (Refereed) Published
Place, publisher, year, edition, pages
WILEY, 2017
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-136994 (URN)000401005301142 ()
Available from: 2017-06-29 Created: 2017-06-29 Last updated: 2019-05-21Bibliographically approved
Lindmark, K., Boman, K., Olofsson, M., Wikstrom, G., Bergman, G. J., Tornblom, M., . . . Stalhammar, J. (2017). Epidemiology of heart failure in Sweden: a retrospective population-based cohort study. European Journal of Heart Failure, 19, 364-364
Open this publication in new window or tab >>Epidemiology of heart failure in Sweden: a retrospective population-based cohort study
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2017 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 19, p. 364-364Article in journal (Refereed) Published
Place, publisher, year, edition, pages
WILEY, 2017
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-136993 (URN)000401005301181 ()
Available from: 2017-06-29 Created: 2017-06-29 Last updated: 2019-05-21Bibliographically approved
Stalhammar, J., Boman, K., Olofsson, M., Wikstrom, G., Bergman, G. J., Tornblom, M., . . . Lindmark, K. (2017). Management of patients with heart failure with preserved versus reduced ejection fraction: a retrospective population-based cohort study in Sweden. European Journal of Heart Failure, 19(Suppl: 1), 54-55
Open this publication in new window or tab >>Management of patients with heart failure with preserved versus reduced ejection fraction: a retrospective population-based cohort study in Sweden
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2017 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 19, no Suppl: 1, p. 54-55Article in journal, Meeting abstract (Refereed) Published
Place, publisher, year, edition, pages
WILEY, 2017
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-137002 (URN)000401005300129 ()
Available from: 2017-06-29 Created: 2017-06-29 Last updated: 2019-05-21Bibliographically approved
Wikstrom, G., Boman, K., Olofsson, M., Stalhammar, J., Bergman, G. J., Tornblom, M., . . . Lindmark, K. (2017). Suboptimal dosing of common heart failure treatments in newly diagnosed patients with heart failure: a retrospective population-based cohort study in Sweden. European Journal of Heart Failure, 19(Suppl: 1), 54-54
Open this publication in new window or tab >>Suboptimal dosing of common heart failure treatments in newly diagnosed patients with heart failure: a retrospective population-based cohort study in Sweden
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2017 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 19, no Suppl: 1, p. 54-54Article in journal, Meeting abstract (Refereed) Published
Place, publisher, year, edition, pages
WILEY, 2017
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-137003 (URN)000401005300128 ()
Available from: 2017-06-29 Created: 2017-06-29 Last updated: 2019-05-21Bibliographically approved
Rautio, A., Boman, K., Gerstein, H. C., Hernestål-Boman, J., Lee, S. F., Olofsson, M. & Garcia Mellbin, L. (2017). The effect of basal insulin glargine on the fibrinolytic system and von Willebrand factor in people with dysglycaemia and high risk for cardiovascular events: Swedish substudy of the Outcome Reduction with an Initial Glargine Intervention trial. Diabetes & Vascular Disease Research, 14(4), 345-352
Open this publication in new window or tab >>The effect of basal insulin glargine on the fibrinolytic system and von Willebrand factor in people with dysglycaemia and high risk for cardiovascular events: Swedish substudy of the Outcome Reduction with an Initial Glargine Intervention trial
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2017 (English)In: Diabetes & Vascular Disease Research, ISSN 1479-1641, E-ISSN 1752-8984, Vol. 14, no 4, p. 345-352Article in journal (Refereed) Published
Abstract [en]

Introduction: Fibrinolytic factors, plasminogen activator inhibitor-1, tissue plasminogen activator, tissue plasminogen activator/plasminogen activator-complex and the haemostatic factor von Willebrand factor are known markers of cardiovascular disease. Their plasma levels are adversely affected in patients with dysglycaemia, and glucose normalization with insulin glargine might improve the levels of these factors. Methods: Prespecified Swedish substudy of the Outcome Reduction with an Initial Glargine Intervention trial (ClinicalTrials.gov number, NCT00069784). Tissue plasminogen activator activity, tissue plasminogen activator antigen, plasminogen activator inhibitor-1 antigen, tissue plasminogen activator/plasminogen activator inhibitor-1 complex and von Willebrand factor were analysed at study start, after 2 years and at the end of the study (median follow-up of 6.2 years). Results: Of 129 patients (mean age of 64 ± 7 years, females: 19%), 68 (53%) and 61 (47%) were randomized to the insulin glargine and standard care group, respectively. Allocation to insulin glargine did not significantly affect the studied fibrinolytic markers or von Willebrand factor compared to standard care. Likewise, there were no significant differences in plasminogen activator inhibitor-1, tissue plasminogen activator antigen and von Willebrand factor. During the whole study period, the within-group analysis revealed a curvilinear pattern and significant changes for tissue plasminogen activator/plasminogen activator inhibitor-1 complex, tissue plasminogen activator antigen and von Willebrand factor in the insulin glargine but not in the standard care group. Conclusion: In people with dysglycaemia and other cardiovascular risk factors, basal insulin does not improve the levels of markers of fibrinolysis or von Willebrand factor compared to standard glucose-lowering treatments.

Place, publisher, year, edition, pages
Sage Publications, 2017
Keywords
Diabetes, insulin glargine, glucose-lowering treatment, fibrinolysis
National Category
Endocrinology and Diabetes Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-113823 (URN)10.1177/1479164117703034 (DOI)000403606900010 ()28403644 (PubMedID)
Note

Originally included in thesis in manuscript form with title: "The effect of basal insulin glargine on the fibrinolytic system and von Willebrand factor in people with dysglycaemia and high risk for cardiovascular events : Swedish substudy of the ORIGIN trial" and authors: Aslak Rautio, Hertzel C Gerstein, Jenny Hernestål-Boman, Shun Fu Lee, Linda Garcia Mellbin, Mona Olofsson, Lars Rydén and Kurt Boman

Available from: 2016-01-04 Created: 2016-01-04 Last updated: 2018-06-25Bibliographically approved
Stalhammar, J., Boman, K., Olofsson, M., Lindmark, K., Lahoz, R., Corda, S., . . . Wikstrom, G. (2016). A description of unselected patients with heart failure: a swedish population-based study. European Journal of Heart Failure, 18, 195-195
Open this publication in new window or tab >>A description of unselected patients with heart failure: a swedish population-based study
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2016 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 18, p. 195-195Article in journal, Meeting abstract (Other academic) Published
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-123460 (URN)10.1002/ejhf.539 (DOI)000377107501269 ()
Available from: 2016-07-12 Created: 2016-07-04 Last updated: 2018-06-07Bibliographically approved
Wikstrom, G., Boman, K., Olofsson, M., Lindmark, K., Lahoz, R., Corda, S., . . . Stalhammar, J. (2016). Dosing of heart failure treatments in newly diagnosed unselected patients in sweden: compliance with european society of cardiology guidelines. European Journal of Heart Failure, 18, 341-341
Open this publication in new window or tab >>Dosing of heart failure treatments in newly diagnosed unselected patients in sweden: compliance with european society of cardiology guidelines
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2016 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 18, p. 341-341Article in journal, Meeting abstract (Other academic) Published
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-123463 (URN)10.1002/ejhf.539 (DOI)000377107503108 ()
Available from: 2016-07-07 Created: 2016-07-04 Last updated: 2018-06-07Bibliographically approved
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