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Berger, E., Delpierre, C., Hosnijeh, F. S., Kelly-Irving, M., Portengen, L., Bergdahl, I., . . . Castagné, R. (2018). Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: findings from two prospective cohorts. Scientific Reports, 8, Article ID 10805.
Open this publication in new window or tab >>Association between low-grade inflammation and Breast cancer and B-cell Myeloma and Non-Hodgkin Lymphoma: findings from two prospective cohorts
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 10805Article in journal (Refereed) Published
Abstract [en]

Chronic inflammation may be involved in cancer development and progression. Using 28 inflammatory-related proteins collected from prospective blood samples from two case-control studies nested in the Italian component of the European Prospective Investigation into Cancer and nutrition (n = 261) and in the Northern Sweden Health and Disease Study (n = 402), we tested the hypothesis that an inflammatory score is associated with breast cancer (BC) and.-cell Non-Hodgkin Lymphoma (B-cell NHL, including 68 multiple myeloma cases) onset. We modelled the relationship between this inflammatory score and the two cancers studied: (BC and B-cell NHL) using generalised linear models, and assessed, through adjustments the role of behaviours and lifestyle factors. Analyses were performed by cancer types pooling both populations, and stratified by cohorts, and time to diagnosis. Our results suggested a lower inflammatory score in B-cell NHL cases (β = -1.28, p = 0.012), and, to lesser, extent with BC (β= -0.96, p = 0.33) compared to controls, mainly driven by cancer cases diagnosed less than 6 years after enrolment. These associations were not affected by subsequent adjustments for potential intermediate confounders, notably behaviours. Sensitivity analyses indicated that our findings were not affected by the way the inflammatory score was calculated. These observations call for further studies involving larger populations, larger variety of cancer types and repeated measures of larger panel of inflammatory markers.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-150362 (URN)10.1038/s41598-018-29041-1 (DOI)000438850900015 ()30018397 (PubMedID)2-s2.0-85050189913 (Scopus ID)
Available from: 2018-08-10 Created: 2018-08-10 Last updated: 2018-08-16Bibliographically approved
Gaudet, M. M., Deubler, E. L., Kelly, R. S., Diver, W. R., Teras, L. R., Hodge, J. M., . . . Kyrtopoulos, S. A. (2018). Blood Levels of Cadmium and Lead in Relation to Breast Cancer Risk in Three Prospective Cohorts.. International Journal of Cancer
Open this publication in new window or tab >>Blood Levels of Cadmium and Lead in Relation to Breast Cancer Risk in Three Prospective Cohorts.
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2018 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215Article in journal (Refereed) Epub ahead of print
Abstract [en]

Cadmium and lead have been classified as carcinogens by the International Agency for Research on Cancer. However, their associations with breast cancer risk are unknown despite their persistence in the environment and ubiquitous human exposure. We examined associations of circulating levels of cadmium and lead with breast cancer risk in three case-control studies nested within the Cancer Prevention Study-II (CPS-II) LifeLink Cohort, European Prospective Investigation into Cancer and Nutrition - Italy (EPIC-Italy), and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Metal levels were measured in stored erythrocytes from 1,435 cases and 1,433 controls using inductively coupled plasma-mass spectrometry. Summary relative risks (RR) and 95% confidence intervals (CI) were calculated using random-effects models with each study result weighted by the within- and between-study variances. I2 values were calculated to estimate proportion of between study variation. Using common cut-points, cadmium levels were not associated with breast cancer risk in the CPS-II cohort (continuous RR=1.01, 95% CI 0.76 - 1.34), but were inversely associated with risk in the EPIC- Italy (continuous RR=0.80, 95% CI 0.61 - 1.03) and NSHDS cohorts (continuous RR=0.73, 95% CI 0.54 - 0.97). The inverse association was also evident in the meta-analysis (continuous RR=0.84, 95% CI 0.69 - 1.01) with low between-study heterogeneity. Large differences in lead level distributions precluded a meta-analysis of their association with breast cancer risk; no associations were found in the three studies. Adult cadmium and lead levels were not associated with higher risk of breast cancer in our large meta-analysis. 

Keywords
breast cancer, cadmium, lead
National Category
Occupational Health and Environmental Health Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-152113 (URN)10.1002/ijc.31805 (DOI)30117163 (PubMedID)
Funder
Swedish Research CouncilVästerbotten County Council
Available from: 2018-09-27 Created: 2018-09-27 Last updated: 2018-12-20
Shirdel, M., Sommar, J. N., Andersson, B. M., Bergdahl, I. A., Wingfors, H. & Liljelind, I. E. (2018). Choosing the number of images and image position when analysing the UNC Passive Aerosol Sampler for occupational exposure assessment. Journal of Occupational and Environmental Hygiene, 15(11), 767-772
Open this publication in new window or tab >>Choosing the number of images and image position when analysing the UNC Passive Aerosol Sampler for occupational exposure assessment
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2018 (English)In: Journal of Occupational and Environmental Hygiene, ISSN 1545-9624, E-ISSN 1545-9632, Vol. 15, no 11, p. 767-772Article in journal (Refereed) Published
Abstract [en]

The University of North Carolina passive aerosol sampler (UNC sampler) could be an alternative when measuring occupational dust exposure, but the time required for microscopic imaging of the sampler needs to be reduced to make it more attractive. The aims of this study were to 1) characterise the effect on precision when reducing imaging, in order to shorten analysis time and 2) assess if the position of the images makes a difference. Eighty-eight samplers were deployed in different locations of an open pit mine. Sixty images were captured for each UNC sampler, covering 51% of its collection surface, using scanning electron microscopy. Bootstrapped samples were generated with different image combinations, to assess the within-sampler coefficient of variation (CVws) for different numbers of images. In addition, the particle concentration relative to the distance from the centre of the sampler was studied. Reducing the number of images collected from the UNC sampler led to up to 8.3% CVws for ten images when calculating respirable fraction. As the overall CV has previously been assessed to 36%, the additional contribution becomes minimal, increasing the overall CV to 37%. The mean concentrations of the images were modestly related to distance from the centre of the sampler. The CVws changed from 8.26% to 8.13% for ten images when applying rules for the image collection based on distance. Thus, the benefit of these rules on the precision is small and the images can therefore be chosen at random. In conclusion, reducing the number of images analysed from 60 to 10, corresponding to a reduction of the imaged sampling area from 51% to 8.5%, results in a negligible loss in precision for respirable fraction dust measurements in occupational environments.

Place, publisher, year, edition, pages
Taylor & Francis, 2018
Keywords
Dust particles, PM10, PM2.5, occupational hygienist, passive sampling, respirable fraction
National Category
Public Health, Global Health, Social Medicine and Epidemiology Environmental Sciences
Identifiers
urn:nbn:se:umu:diva-152114 (URN)10.1080/15459624.2018.1508875 (DOI)000451621900002 ()30111275 (PubMedID)
Available from: 2018-09-27 Created: 2018-09-27 Last updated: 2018-12-19Bibliographically approved
Campanella, G., Gunter, M. J., Polidoro, S., Krogh, V., Palli, D., Panico, S., . . . Chadeau-Hyam, M. (2018). Epigenome-wide association study of adiposity and future risk of obesity-related diseases. International Journal of Obesity, 42(12), 2022-2035
Open this publication in new window or tab >>Epigenome-wide association study of adiposity and future risk of obesity-related diseases
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2018 (English)In: International Journal of Obesity, ISSN 0307-0565, E-ISSN 1476-5497, Vol. 42, no 12, p. 2022-2035Article in journal (Refereed) Published
Abstract [en]

Background Obesity is an established risk factor for several common chronic diseases such as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the biological basis for these relationships is not fully understood. To explore the association of obesity with these conditions, we investigated peripheral blood leucocyte (PBL) DNA methylation markers for adiposity and their contribution to risk of incident breast and colorectal cancer and myocardial infarction. Methods DNA methylation profiles (Illumina Infinium® HumanMethylation450 BeadChip) from 1941 individuals from four population-based European cohorts were analysed in relation to body mass index, waist circumference, waist-hip and waistheight ratio within a meta-analytical framework. In a subset of these individuals, data on genome-wide gene expression level, biomarkers of glucose and lipid metabolism were also available. Validation of methylation markers associated with all adiposity measures was performed in 358 individuals. Finally, we investigated the association of obesity-related methylation marks with breast, colorectal cancer and myocardial infarction within relevant subsets of the discovery population. Results We identified 40 CpG loci with methylation levels associated with at least one adiposity measure. Of these, one CpG locus (cg06500161) in ABCG1 was associated with all four adiposity measures (P=9.07×10−8 to 3.27×10−18) and lower transcriptional activity of the full-length isoform of ABCG1 (P=6.00×10−7), higher triglyceride levels (P=5.37×10−9) and higher triglycerides-to-HDL cholesterol ratio (P=1.03×10−10). Of the 40 informative and obesity-related CpG loci, two (in IL2RB and FGF18) were significantly associated with colorectal cancer (inversely, P<1.6×10−3) and one intergenic locus on chromosome 1 was inversely associated with myocardial infarction (P<1.25×10−3), independently of obesity and established risk factors. Conclusion Our results suggest that epigenetic changes, in particular altered DNA methylation patterns, may be an intermediate biomarker at the intersection of obesity and obesity-related diseases, and could offer clues as to underlying biological mechanisms.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-154848 (URN)10.1038/s41366-018-0064-7 (DOI)000452830800009 ()29713043 (PubMedID)2-s2.0-85046105580 (Scopus ID)
Funder
EU, European Research Council, 232997
Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-01-07Bibliographically approved
Campanella, G., Gunter, M. J., Polidoro, S., Krogh, V., Palli, D., Panico, S., . . . Chadeau-Hyam, M. (2018). Epigenome-wide association study of adiposity and future risk of obesity-related diseases. International Journal of Obesity, 42(12), 2022-2035
Open this publication in new window or tab >>Epigenome-wide association study of adiposity and future risk of obesity-related diseases
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2018 (English)In: International Journal of Obesity, ISSN 0307-0565, E-ISSN 1476-5497, Vol. 42, no 12, p. 2022-2035Article in journal (Refereed) Published
Abstract [en]

Background: Obesity is an established risk factor for several common chronic diseases such as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the biological basis for these relationships is not fully understood. To explore the association of obesity with these conditions, we investigated peripheral blood leucocyte (PBL) DNA methylation markers for adiposity and their contribution to risk of incident breast and colorectal cancer and myocardial infarction.

Methods: DNA methylation profiles (Illumina Infinium® HumanMethylation450 BeadChip) from 1941 individuals from four population-based European cohorts were analysed in relation to body mass index, waist circumference, waist-hip and waist-height ratio within a meta-analytical framework. In a subset of these individuals, data on genome-wide gene expression level, biomarkers of glucose and lipid metabolism were also available. Validation of methylation markers associated with all adiposity measures was performed in 358 individuals. Finally, we investigated the association of obesity-related methylation marks with breast, colorectal cancer and myocardial infarction within relevant subsets of the discovery population.

Results: We identified 40 CpG loci with methylation levels associated with at least one adiposity measure. Of these, one CpG locus (cg06500161) in ABCG1 was associated with all four adiposity measures (P = 9.07×10−8 to 3.27×10−18) and lower transcriptional activity of the full-length isoform of ABCG1 (P = 6.00×10−7), higher triglyceride levels (P = 5.37×10−9) and higher triglycerides-to-HDL cholesterol ratio (P = 1.03×10−10). Of the 40 informative and obesity-related CpG loci, two (in IL2RB and FGF18) were significantly associated with colorectal cancer (inversely, P < 1.6×10−3) and one intergenic locus on chromosome 1 was inversely associated with myocardial infarction (P < 1.25×10−3), independently of obesity and established risk factors.

Conclusion: Our results suggest that epigenetic changes, in particular altered DNA methylation patterns, may be an intermediate biomarker at the intersection of obesity and obesity-related diseases, and could offer clues as to underlying biological mechanisms.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018
National Category
Endocrinology and Diabetes Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-154895 (URN)10.1038/s41366-018-0064-7 (DOI)000452830800009 ()29713043 (PubMedID)
Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-01-07Bibliographically approved
Adlard, B., Donaldson, S. G., Odland, J. O., Weihe, P., Berner, J., Carlsen, A., . . . Mulvad, G. (2018). Future directions for monitoring and human health research for the Arctic Monitoring and Assessment Programme. Global Health Action, 11(1), Article ID 1480084.
Open this publication in new window or tab >>Future directions for monitoring and human health research for the Arctic Monitoring and Assessment Programme
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2018 (English)In: Global Health Action, ISSN 1654-9716, E-ISSN 1654-9880, Vol. 11, no 1, article id 1480084Article in journal (Refereed) Published
Abstract [en]

For the last two and a half decades, a network of human health experts under the Arctic Monitoring and Assessment Program (AMAP) has produced several human health assessment reports. These reports have provided a base of scientific knowledge regarding environmental contaminants and their impact on human health in the Arctic. These reports provide scientific information and policy-relevant recommendations to Arctic governments. They also support international agreements such as the Stockholm Convention on Persistent Organic Pollutants (POPs) and the Minamata Convention on Mercury. Key topics discussed in this paper regarding future human health research in the circumpolar Arctic are continued contaminant biomonitoring, health effects research and risk communication. The objective of this paper is to describe knowledge gaps and future priorities for these fields.

Place, publisher, year, edition, pages
Taylor & Francis, 2018
Keywords
Arctic, human health, biomonitoring, environmental contaminants
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-150770 (URN)10.1080/16549716.2018.1480084 (DOI)000436336300001 ()29943674 (PubMedID)
Available from: 2018-08-31 Created: 2018-08-31 Last updated: 2018-08-31Bibliographically approved
Bohler, S., Espín-Pérez, A., Gebel, S., Bergdahl, I., Palli, D., Rantakokko, P., . . . Kleinjans, J. C. (2018). Genes associated with Parkinson's disease respond to increasing polychlorinated biphenyl levels in the blood of healthy females. Paper presented at 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box, SEP 02-05, 2018, Brussels, BELGIUM. Toxicology Letters, 295, S159-S160
Open this publication in new window or tab >>Genes associated with Parkinson's disease respond to increasing polychlorinated biphenyl levels in the blood of healthy females
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2018 (English)In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 295, p. S159-S160Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Elsevier, 2018
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:umu:diva-155247 (URN)10.1016/j.toxlet.2018.06.774 (DOI)000454045100440 ()
Conference
54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box, SEP 02-05, 2018, Brussels, BELGIUM
Note

Supplement: 1

Meeting Abstract: P12-03

Available from: 2019-01-14 Created: 2019-01-14 Last updated: 2019-01-14Bibliographically approved
Shirdel, M., Andersson, B. M., Bergdahl, I., Sommar, J. N., Wingfors, H. & Liljelind, I. E. (2018). Improving the UNC passive aerosol sampler model based on comparison with commonly used aerosol sampling methods. Annals of Work Exposures and Health, 62(3), 328-338
Open this publication in new window or tab >>Improving the UNC passive aerosol sampler model based on comparison with commonly used aerosol sampling methods
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2018 (English)In: Annals of Work Exposures and Health, ISSN 2398-7308, Vol. 62, no 3, p. 328-338Article in journal (Refereed) Published
Abstract [en]

Objectives: In an occupational environment, passive sampling could be an alternative to active sampling with pumps for sampling of dust. One passive sampler is the University of North Carolina passive aerosol sampler (UNC sampler). It is often analysed by microscopic imaging. Promising results have been shown for particles above 2.5 µm, but indicate large underestimations for PM2.5. The aim of this study was to evaluate, and possibly improve, the UNC sampler for stationary sampling in a working environment.

Methods: Sampling was carried out at 8-h intervals during 24 h in four locations in an open pit mine with UNC samplers, respirable cyclones, PM10 and PM2.5 impactors, and an aerodynamic particle sizer (APS). The wind was minimal. For quantification, two modifications of the UNC sampler analysis model, UNC sampler with hybrid model and UNC sampler with area factor, were compared with the original one, UNC sampler with mesh factor derived from wind tunnel experiments. The effect of increased resolution for the microscopic imaging was examined.

Results: Use of the area factor and a higher resolution eliminated the underestimation for PM10 and PM2.5. The model with area factor had the overall lowest deviation versus the impactor and the cyclone. The intraclass correlation (ICC) showed that the UNC sampler had a higher precision and better ability to distinguish between different exposure levels compared to the cyclone (ICC: 0.51 versus 0.24), but lower precision compared to the impactor (PM10: 0.79 versus 0.99; PM2.5: 0.30 versus 0.45). The particle size distributions as calculated from the different UNC sampler analysis models were visually compared with the distributions determined by APS. The distributions were obviously different when the UNC sampler with mesh factor was used but came to a reasonable agreement when the area factor was used.

Conclusions: High resolution combined with a factor based on area only, results in no underestimation of small particles compared to impactors and cyclones and a better agreement with the APS’s particle size distributions. The UNC sampler had lower precision than the impactors, but higher than the respirable cyclone. The UNC sampler with area factor could be used for PM2.5, PM10 and respirable fraction measurements in this working environment without wind.

Place, publisher, year, edition, pages
Oxford University Press, 2018
Keywords
inorganic dust, mesh factor, PM10, PM2.5, respirable fraction, UNC passive aerosol sampler, working environment
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-145698 (URN)10.1093/annweh/wxx110 (DOI)000432804600008 ()29300818 (PubMedID)
Available from: 2018-03-14 Created: 2018-03-14 Last updated: 2018-06-26Bibliographically approved
Wennberg, M., Ruuth, A., Andersson, L. & Bergdahl, I. A. (2018). Mercury concentrations in pregnant women in circumpolar Sweden (Kiruna). Umeå: Umeå universitet
Open this publication in new window or tab >>Mercury concentrations in pregnant women in circumpolar Sweden (Kiruna)
2018 (English)Report (Other academic)
Abstract [en]

High exposure to mercury have been found in populations living in circumpolar areas, due to high consumption of sea food and accumulation of mercury closer to the north pole. The developing fetus is especially sensitive to effects of mercury. Exposure to mercury has previously been examined in pregnant women in Sweden, but not in pregnant women residing in Sweden north of the polar circle.

In the years 2015-2016, mercury was measured in whole blood from 51 pregnant women living in the city of Kiruna in circumpolar Sweden, taking part in an international comparison between eight circumpolar countries. This report presents the Swedish results on mercury concentrations and associations with some exposure determinants. Also, compliance to dietary advice on fish consumption, appointed to fertile women, was examined.

The median concentration of total-Hg in whole blood was 0.40 μg/L (min, max; <0.40, 1.88) among the 51 pregnant women in Kiruna. This is similar or lower compared to concentrations of mercury in pregnant women in other parts of Sweden. None of the women in the study had concentrations of mercury that are considered as dangerous.

Mercury concentrations were associated with total fish consumption but not to consumption of predatory fish, known to be higher in mercury. All of the women in the study had knowledge about dietary advice on fish consumption. One woman exceeded the recommended consumption of predatory fish, limited due to risk of high mercury content, but this woman did not have high concentrations of mercury. While the vast majority of women thus followed the recommendations of not eating too much polluted fish, only 15 % of the women reported sufficient fish consumption to comply with the dietary advice (2-3 times/week).

In conclusion, pregnant women in circumpolar Sweden have low exposure to mercury, and do not deviant from pregnant women in other parts of Sweden. Knowledge about dietary advice on fish consumption appointed to fertile women is very good. The public health concern though, is that pregnant women in circumpolar Sweden do not eat enough fish.

Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2018. p. 16
Series
Yrkes- och miljömedicin i umeå rapporterar, ISSN 1654-7314 ; 2018:3
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-147733 (URN)
Available from: 2018-05-16 Created: 2018-05-16 Last updated: 2018-08-21Bibliographically approved
Wennberg, M., Lindh, C. & Bergdahl, I. (2018). Organiska miljöföroreningar i urin hos unga i norra och södra Sverige. Umeå: Umeå universitet
Open this publication in new window or tab >>Organiska miljöföroreningar i urin hos unga i norra och södra Sverige
2018 (Swedish)Report (Other academic)
Abstract [sv]

Det är viktigt att följa halter av miljöföroreningar hos människor, för riskvärdering och för att få kunskap om hur exponeringen kan minskas.

Organiska miljöföroreningar (ftalat-metaboliter, bisfenol A, bisfenol F, triklosan, pesticiderna 3-PBA och TCP samt PAH-metaboliten 1-HP) analyserades i urin hos 204 unga i Skåne (gymnasieelever, år 2013) och hos 143 unga i MONICA-studien i norra Sverige (25-35 år, år 2014). Koncentrationer jämfördes statistiskt mellan studierna och kopplingar till levnadsvanor som efterfrågades i båda studierna undersöktes (rökning, fiskintag, intag av mat från konserver och typ av golv i sovrum). En kompletterande enkätstudie gjordes på deltagarna i MONICA-studien som uppgav att de hade plastgolv i sovrummet (n=65), för att utröna om golvvärme under plastgolv i sovrummet kan öka exponering av "plast-ftalaten" MBzP.

De statistiskt säkerställda skillnader som uppdagades var att de unga i norr hade högre koncentration av de flesta ftalat-metaboliter och av pesticiden 3-PBA medan de unga i söder hade högre koncentration av triklosan.

Ftalat-metaboliten MBzP kunde kopplas till att ha plastgolv i sovrummet i båda studiepopulationerna. Då endast fyra personer i MONICA-studien uppgav golvvärme under plastgolv och den gruppen inte hade anmärkningsvärt hög MBzP-koncentration i urin kan inte högre användning av golvvärme i norr vara förklaringen till högre koncentration av MBzP i norra Sverige.

Skillnader i levnadsförhållanden av betydelse för exponering av miljöföroreningarna som beror på den åldersskillnad som fanns mellan studiepopulationerna i norr och söder, och inte undersöktes i den här studien, kan inte uteslutas. Framtida geografiska jämförelser av miljöföroreningar hos människor bör om möjligt göras på människor i samma åldersintervall.

Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2018. p. 20
Series
Yrkes- och miljömedicin i Umeå rapporterar, ISSN 1654-7314 ; 2018:4
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-148119 (URN)
Available from: 2018-05-29 Created: 2018-05-29 Last updated: 2018-08-22
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-1227-6859

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