umu.sePublications
Change search
Link to record
Permanent link

Direct link
BETA
Gärskog, Ola
Publications (4 of 4) Show all publications
Lindblom, U., Nilsson, P., Gärskog, O., Kjellen, E., Laurell, G., Wahlberg, P., . . . Levring Jäghagen, E. (2016). Aspiration as a late complication after accelerated versus conventional radiotherapy in patients with head and neck cancer. Acta Oto-Laryngologica, 136(3), 304-311
Open this publication in new window or tab >>Aspiration as a late complication after accelerated versus conventional radiotherapy in patients with head and neck cancer
Show others...
2016 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 136, no 3, p. 304-311Article in journal (Refereed) Published
Abstract [en]

Conclusion Neck dissection after radiotherapy increased the risk of aspiration as a late effect in a sub-sample of patients treated for head and neck cancer in the ARTSCAN study. Patients treated with accelerated fractionation (AF) developed aspiration, with or without coughing, more frequently than patients treated with conventional fractionation (CF). Objectives A long-term follow-up study was conducted to determine the frequency of aspiration as a late effect in patients with head and neck cancer treated with AF or CF. Method One-hundred and eight patients were recruited from two centres of the Swedish multi-centre study, ARTSCAN, where AF and CF were compared. Patients with positive lymph nodes were treated with neck dissection after completing radiotherapy. The follow-up was performed at a median of 65 months after initiation of radiotherapy and included an ENT and a videofluoroscopic examination. Results Aspiration was found in 51/108 (47%) and silent aspiration in 34/96 (35%) patients. Neck dissection (n = 47 patients) was significantly associated with both aspiration and silent aspiration. Aspiration was more common among patients treated with AF (34/61; 56%) compared to CF (17/47; 36%; p = 0.053). Silent aspiration was also more common after AF (24/54; 44%) than after CF (10/42; 24%; p = 0.052).

Place, publisher, year, edition, pages
Taylor & Francis, 2016
Keywords
Late effect, dysphagia, follow-up, neck dissection, sequelae, swallowing disorders, videofluoroscopy
National Category
Cancer and Oncology Otorhinolaryngology
Research subject
Oncology; Odontology; Radiology; radiation physics; Oto-Rhino-Laryngology
Identifiers
urn:nbn:se:umu:diva-115781 (URN)10.3109/00016489.2015.1113439 (DOI)000375933300017 ()26838580 (PubMedID)
Projects
ARTSCAN
Available from: 2016-02-04 Created: 2016-02-04 Last updated: 2018-06-07Bibliographically approved
Gu, X., Boldrup, L., Coates, P. J., Fåhraeus, R., Nylander, E., Loizou, C., . . . Nylander, K. (2016). Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites. Scientific Reports, 6, Article ID 32579.
Open this publication in new window or tab >>Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites
Show others...
2016 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, article id 32579Article in journal (Refereed) Published
Abstract [en]

Epigenetic modifications are essential regulators of biological processes. Decreased DNA methylation of OAS2 (2'-5'-Oligoadenylate Synthetase 2), encoding an antiviral protein, has been seen in psoriasis. To provide further insight into the epigenetic regulation of OAS2, we performed pyrosequencing to detect OAS2 DNA methylation status at 11 promoter and first exon located CpG sites in psoriasis (n = 12) and two common subtypes of squamous cell carcinoma (SCC) of the head and neck: tongue (n = 12) and tonsillar (n = 11). Compared to corresponding controls, a general hypomethylation was seen in psoriasis. In tongue and tonsillar SCC, hypomethylation was found at only two CpG sites, the same two sites that were least demethylated in psoriasis. Despite differences in the specific residues targeted for methylation/demethylation, OAS2 expression was upregulated in all conditions and correlations between methylation and expression were seen in psoriasis and tongue SCC. Distinctive methylation status at four successively located CpG sites within a genomic area of 63 bp reveals a delicately integrated epigenetic program and indicates that detailed analysis of individual CpGs provides additional information into the mechanisms of epigenetic regulation in specific disease states. Methylation analyses as clinical biomarkers need to be tailored according to disease-specific sites.

Keywords
Tympanic membrane, myringoplasty, perforation, Gelfoam®
National Category
Medical Genetics
Identifiers
urn:nbn:se:umu:diva-125822 (URN)10.1038/srep32579 (DOI)000391984400001 ()27572959 (PubMedID)
Available from: 2017-02-22 Created: 2017-02-22 Last updated: 2018-06-09Bibliographically approved
Lindblom, U., Gärskog, O., Kjellén, E., Laurell, G., Levring Jäghagen, E., Wahlberg, P., . . . Nilsson, P. (2014). Radiation-induced trismus in the ARTSCAN head and neck trial. Acta Oncologica, 53(5), 620-627
Open this publication in new window or tab >>Radiation-induced trismus in the ARTSCAN head and neck trial
Show others...
2014 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 53, no 5, p. 620-627Article in journal (Refereed) Published
Abstract [en]

Trismus, a well-known sequelae after treatment of head and neck cancer, decreases a patient's oral function and quality of life. The main objectives of this study were to: 1) investigate the long-term prevalence of radiation-induced trismus in patients treated for head and neck cancer according to two different fractionation schedules; and 2) model a dose-response relationship for trismus. MATERIAL AND METHODS: Patients were recruited from the Swedish ARTSCAN trial, a prospective randomised multicentre study comparing conventional and accelerated fractionation. A total of 124 patients agreed to a clinical ENT examination 21-127 months (median 66 months) after beginning radiation therapy. Trismus-related scores were assessed using the EORTC H&N35 Quality of Life questionnaire. The TheraBite(®) range of motion scale was used to measure maximal interincisal distance. The dose-response relationship for structures important for mastication and the temporomandibular joints was investigated by normal tissue complication probability modelling. RESULTS: No significant differences in patient-reported trismus or maximal interincisal distance were found between the two trial arms. Patient-reported moderate to high scores regarding trismus increased from 3% at the start of radiation therapy to 25% at the long-term follow-up. Maximal interincisal distance correlated significantly with patient-reported scores of trismus. The best dose-response fit to the endpoint data was found for the dose to the ipsilateral masseter. CONCLUSIONS: Trismus is a persistent complication after radiotherapy with 3D-conformal radiation therapy. We found no difference between the severity and prevalence of trismus between conventional and accelerated fractionation, but a significant correlation between the absorbed dose to the mastication structures and opening of the mouth. Further prospective studies may determine whether a reduced dose to structures important for mastication using intensity-modulated radiation therapy will reduce problems with trismus.

Place, publisher, year, edition, pages
Informa Healthcare, 2014
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-87737 (URN)10.3109/0284186X.2014.892209 (DOI)000334740000007 ()24669774 (PubMedID)
Available from: 2014-04-08 Created: 2014-04-08 Last updated: 2018-06-08Bibliographically approved
Borzacchiello, A., Mayol, L., Ambrosio, L., Gärskog, O. & Dahlqvist, Å. (2004). Rheological characterization of vocal folds after injection augmentation in a preliminary animal study. Journal of bioactive and compatible polymers (Print), 19(4), 331-341
Open this publication in new window or tab >>Rheological characterization of vocal folds after injection augmentation in a preliminary animal study
Show others...
2004 (English)In: Journal of bioactive and compatible polymers (Print), ISSN 0883-9115, E-ISSN 1530-8030, Vol. 19, no 4, p. 331-341Article in journal (Refereed) Published
Abstract [en]

The investigation of vocal folds viscoelastic properties in an animal model (rabbit) after injection of various augmentation substances, 6 months after injection, is reported. The injected materials were: hyaluronan-based materials (Hylan B gel and Deflux(R)), cross-linked collagen (Zyplast(R)) and polytetrafluoroethylene (Teflon(R)). Rheological properties of the augmentation substances were also evaluated. The results from these animal experiments indicate that the viscoelastic properties of the vocal folds injected with Deflux(R), Zyplast(R) and Hylan B gel are similar to the healthy vocal folds (non-injected samples) used as control, thus demonstrating that these materials are good candidates for further studies aimed at restoring/preserving the vibratory capacity of the vocal folds with injection treatment in glottal insufficiency.

Place, publisher, year, edition, pages
London: Sage Publications, 2004
Keywords
viscoelasticity, vocal folds, injection, augmentation, hyaluronan
National Category
Medical Biotechnology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
urn:nbn:se:umu:diva-122164 (URN)10.1177/0883911504045229 (DOI)000222856900006 ()
Available from: 2016-06-21 Created: 2016-06-15 Last updated: 2018-06-07Bibliographically approved
Organisations

Search in DiVA

Show all publications