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Nyqvist, Johanna
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Nyqvist, J., Fransson, P., Laurell, G., Hammerlid, E., Kjellén, E., Franzén, L., . . . Zackrisson, B. (2016). Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer: A five year follow up. Radiotherapy and Oncology, 118(2), 335-341
Open this publication in new window or tab >>Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer: A five year follow up
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2016 (English)In: Radiotherapy and Oncology, ISSN 0167-8140, E-ISSN 1879-0887, Vol. 118, no 2, p. 335-341Article in journal (Refereed) Published
Abstract [en]

Background and purpose: Health related quality of life (HRQoL) was assessed in the randomised, prospective ARTSCAN study comparing conventional radiotherapy (CF) with accelerated radiotherapy (AF) for head and neck cancer.

Material and methods: 750 patients with squamous cell carcinoma (of any grade and stage) in the oral cavity, oro-, or hypopharynx or larynx (except T1-2, NO glottic carcinoma) without distant metastases were randomised to either conventional fractionation (2 Gy/day, 5 days/week in 49 days, total dose 68 Gy) or accelerated fractionation (1.1 + 2.0 Gy/day, 5 days/week in 35 days, total dose 68 Gy). HRQoL was assessed with EORTC QLQ-C30, QLQ-H&N35 and HADS at baseline, at end of radiotherapy (eRT) and at 3 and 6 months and 1, 2 and 5 years after start of treatment.

Results: The AF group reported HRQoL was significantly lower at eRT and at 3 months for most symptoms, scales and functions. Few significant differences were noted between the groups at 6 months and 5 years. Scores related to functional oral intake never reached baseline.

Conclusion: In comparison to CF, AF has a stronger adverse effect on HRQoL in the acute phase.

Keywords
Health related quality of life, Accelerated radiotherapy, Head and neck cancer, Quality of life, Accelerated fractionation
National Category
Cancer and Oncology Nursing
Identifiers
urn:nbn:se:umu:diva-120668 (URN)10.1016/j.radonc.2015.12.024 (DOI)000373420000019 ()26777124 (PubMedID)
Available from: 2016-06-16 Created: 2016-05-18 Last updated: 2019-06-27Bibliographically approved
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