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Bygren, Lars Olov
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Publications (10 of 16) Show all publications
Bygren, L. O., Tinghög, P., Carstensen, J., Edvinsson, S., Kaati, G., Pembrey, M. E. & Sjöström, M. (2014). Change in paternal grandmothers' early food supply influenced cardiovascular mortality of the female grandchildren. BMC Genetics, 15, 12
Open this publication in new window or tab >>Change in paternal grandmothers' early food supply influenced cardiovascular mortality of the female grandchildren
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2014 (English)In: BMC Genetics, ISSN 1471-2156, E-ISSN 1471-2156, Vol. 15, p. 12-Article in journal (Refereed) Published
Abstract [en]

Background: This study investigated whether large fluctuations in food availability during grandparents' early development influenced grandchildren's cardiovascular mortality. We reported earlier that changes in availability of food - from good to poor or from poor to good - during intrauterine development was followed by a double risk of sudden death as an adult, and that mortality rate can be associated with ancestors' childhood availability of food. We have now studied transgenerational responses (TGR) to sharp differences of harvest between two consecutive years' for ancestors of 317 people in Overkalix, Sweden. Results: The confidence intervals were very wide but we found a striking TGR. There was no response in cardiovascular mortality in the grandchild from sharp changes of early exposure, experienced by three of the four grandparents (maternal grandparents and paternal grandfathers). If, however, the paternal grandmother up to puberty lived through a sharp change in food supply from one year to next, her sons' daughters had an excess risk for cardiovascular mortality (HR 2.69, 95% confidence interval 1.05-6.92). Selection or learning and imitation are unlikely explanations. X-linked epigenetic inheritance via spermatozoa seemed to be plausible, with the transmission, limited to being through the father, possibly explained by the sex differences in meiosis. Conclusion: The shock of change in food availability seems to give specific transgenerational responses.

Place, publisher, year, edition, pages
BioMed Central, 2014
Keywords
Epidemiology, Food change, Environmental shock, Human transgenerational response, Cardiovascular mortality, Overkalix
National Category
Health Sciences
Identifiers
urn:nbn:se:umu:diva-88969 (URN)10.1186/1471-2156-15-12 (DOI)000334611200001 ()
Available from: 2014-05-23 Created: 2014-05-19 Last updated: 2018-06-07Bibliographically approved
Pembrey, M., Saffery, R. & Bygren, L. O. (2014). Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research. Journal of Medical Genetics, 51(9), 563-572
Open this publication in new window or tab >>Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research
2014 (English)In: Journal of Medical Genetics, ISSN 0022-2593, E-ISSN 1468-6244, Journal of Medical Genetics, ISSN 0022-2593, Vol. 51, no 9, p. 563-572Article, review/survey (Refereed) Published
Abstract [en]

Mammalian experiments provide clear evidence of male line transgenerational effects on health and development from paternal or ancestral early-life exposures such as diet or stress. The few human observational studies to date suggest (male line) transgenerational effects exist that cannot easily be attributed to cultural and/or genetic inheritance. Here we summarise relevant studies, drawing attention to exposure sensitive periods in early life and sex differences in transmission and offspring outcomes. Thus, variation, or changes, in the parental/ancestral environment may influence phenotypic variation for better or worse in the next generation(s), and so contribute to common, non-communicable disease risk including sex differences. We argue that life-course epidemiology should be reframed to include exposures from previous generations, keeping an open mind as to the mechanisms that transmit this information to offspring. Finally, we discuss animal experiments, including the role of epigenetic inheritance and non-coding RNAs, in terms of what lessons can be learnt for designing and interpreting human studies. This review was developed initially as a position paper by the multidisciplinary Network in Epigenetic Epidemiology to encourage transgenerational research in human cohorts.

Place, publisher, year, edition, pages
BMJ Books, 2014
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-92902 (URN)10.1136/jmedgenet-2014-102577 (DOI)000340242400001 ()
Available from: 2014-09-18 Created: 2014-09-09 Last updated: 2018-06-07Bibliographically approved
Eriksson, A., Stenlund, H., Ahlm, K., Boman, K., Bygren, L. O., Johansson, L. A., . . . Weinehall, L. (2013). Accuracy of death certificates of cardiovascular disease in a community intervention in Sweden.. Scandinavian Journal of Public Health, 41(8), 883-889
Open this publication in new window or tab >>Accuracy of death certificates of cardiovascular disease in a community intervention in Sweden.
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2013 (English)In: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, Vol. 41, no 8, p. 883-889Article in journal (Refereed) Published
Abstract [en]

Aim: The aim was to investigate the possibility to evaluate the mortality pattern in a community intervention programme against cardiovascular disease by official death certificates.

Methods: For all deceased in the intervention area (Norsjö), the accuracy of the official death certificates were compared with matched controls in the rest of Västerbotten. The official causes of death were compared with new certificates, based on the last clinical record, issued by three of the authors, and coded by one of the authors, all four accordingly blinded.

Results: The degree of agreement between the official underlying causes of death in "cardiovascular disease" (CVD) and the re-evaluated certificates was not found to differ between Norsjö and the rest of Västerbotten. The agreement was 87% and 88% at chapter level, respectively, but only 55% and 55% at 4-digit level, respectively. The reclassification resulted in a 1% decrease of "cardiovascular deaths" in both Norsjö and the rest of Västerbotten.

Conclusions: The disagreements in the reclassification of cause of death were equal but large in both directions. The official death certificates should be used with caution to evaluate CVD in small community intervention programmes, and restricted to the chapter level and total populations.

Keywords
Accuracy, agreement, cardiovascular disease, cause of death, death certificate, re-classification
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-83346 (URN)10.1177/1403494813499653 (DOI)000330514500017 ()23982462 (PubMedID)
Available from: 2013-11-21 Created: 2013-11-21 Last updated: 2018-06-08Bibliographically approved
Bygren, L. O. (2013). Intergenerational health responses to adverse and enriched environments. Annual review of public health (Print), 34, 49-60
Open this publication in new window or tab >>Intergenerational health responses to adverse and enriched environments
2013 (English)In: Annual review of public health (Print), ISSN 0163-7525, E-ISSN 1545-2093, Vol. 34, p. 49-60Article in journal (Refereed) Published
Abstract [en]

Health consequences of relative or absolute poverty constitute a definitive area of study in social medicine. As demonstrated in the extreme example of the Dutch Hunger Winter from 1944 to 1945, prenatal hunger can lead to adult schizophrenia and depression. A Norwegian study showed how childhood poverty resulted in a heightened risk of myocardial infarction in adulthood. In England, a study of extended impaired prenatal nutrition indicated three different types of increased cardiovascular risk at older ages. Current animal and human studies link both adverse and enriched environmental exposures to intergenerational transmission. We do not fully understand the molecular mechanisms for it; however, studies that follow up epigenetic marks within a generation combined with exploration of gametic epigenetic inheritance may help explain the prevalence of certain conditions such as cardiovascular disease, schizophrenia, and alcoholism, which have complex etiologies. Insights from these studies will be of great public health importance.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-79392 (URN)10.1146/annurev-publhealth-031912-114419 (DOI)000321892700006 ()23297658 (PubMedID)
Available from: 2013-08-16 Created: 2013-08-16 Last updated: 2018-06-08Bibliographically approved
Cuypers, K., Krokstad, S., Holmen, T. L., Knudtsen, M. S., Bygren, L. O. & Holmen, J. (2012). Patterns of receptive and creative cultural activities and their association with perceived health, anxiety, depression and satisfaction with life among adults: the HUNT study, Norway. Journal of Epidemiology and Community Health, 66(8), 698-703
Open this publication in new window or tab >>Patterns of receptive and creative cultural activities and their association with perceived health, anxiety, depression and satisfaction with life among adults: the HUNT study, Norway
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2012 (English)In: Journal of Epidemiology and Community Health, ISSN 0143-005X, E-ISSN 1470-2738, Vol. 66, no 8, p. 698-703Article in journal (Refereed) Published
Abstract [en]

Background Cultural participation has been used both in governmental health policies and as medical therapy, based on the assumption that cultural activities will improve health. Previous population studies and a human intervention study have shown that religious, social and cultural activities predict increased survival rate. The aim of this study was to analyse the association between cultural activity and perceived health, anxiety, depression and satisfaction with life in both genders. Methods The study is based on the third population-based Nord-Trondelag Health Study (2006-2008), including 50 797 adult participants from Nord-Trondelag County, Norway. Data on cultural activities, both receptive and creative, perceived health, anxiety, depression and satisfaction with life were collected by comprehensive questionnaires. Results The logistic regression models, adjusted for relevant cofactors, show that participation in receptive and creative cultural activities was significantly associated with good health, good satisfaction with life, low anxiety and depression scores in both genders. Especially in men, attending receptive, rather than creative, cultural activities was more strongly associated with all health-related outcomes. Statistically significant associations between several single receptive, creative cultural activities and the health-related outcome variables were revealed. Conclusion This population-based study suggests gender-dependent associations between cultural participation and perceived health, anxiety, depression and satisfaction with life. The results support hypotheses on the effect of cultural activities in health promotion and healthcare, but further longitudinal and experimental studies are warranted to establish a reliable cause-effect relationship.

Place, publisher, year, edition, pages
London: BMJ Publishing Group, 2012
National Category
Health Sciences
Identifiers
urn:nbn:se:umu:diva-58156 (URN)10.1136/jech.2010.113571 (DOI)000306526400007 ()
Available from: 2012-08-29 Created: 2012-08-27 Last updated: 2018-06-08Bibliographically approved
Håglin, L., Lundström, S., Kaati, G., Bäckman, L. & Bygren, L. O. (2011). All-cause mortality of patients with dyslipidemia up to 19 years after a multidisciplinary lifestyle modification programme: a randomized trial. European Journal of Cardiovascular Prevention & Rehabilitation, 18(1), 79-85
Open this publication in new window or tab >>All-cause mortality of patients with dyslipidemia up to 19 years after a multidisciplinary lifestyle modification programme: a randomized trial
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2011 (English)In: European Journal of Cardiovascular Prevention & Rehabilitation, ISSN 1741-8267, E-ISSN 1741-8275, Vol. 18, no 1, p. 79-85Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Many studies have shown that individual lifestyle factors are associated with cardiovascular mortality and all-cause mortality. Observational studies of comprehensive programmes have reported risk reductions. The objectives were to assess the long-term all-cause mortality by diagnosis in patients referred to a lifestyle modification programme, aimed at combating coronary heart disease and stroke.

METHODS: A randomized trial with 325 patients referred to the centre between 1988 and 1989 for dyslipidemia, hypertension, type 2 diabetes and coronary heart disease; 239 patients were randomized to the programme, 86 randomized to usual care. Cases were admitted to the centre in groups of 30 for a 4-week residential comprehensive activity, in total 114 full-time hours, focusing on food preferences and selections, and physical exercise. The activities were repeated during a 4-day revisit to the centre 1 year and 5 years after the 4-week intervention. Controls were referred back to their doctors, mainly in primary care, for usual care. Main outcome measure was all-cause mortality during 11-12 and 18-19 years after intervention.

RESULTS: At follow-up 11-12 years after referral, the relative risk reduction (RRR) was 76% with the intention-to-treat analysis among cases admitted for dyslipidemia (hazards ratio 0.24, confidence interval 0.06-0.89, P=0.033). After 18-19 years, the RRR was 66% (hazards ratio 0.34, confidence interval 0.13-0.88, P=0.026). No RRR was found for the other three diagnoses.

CONCLUSION: Patients admitted for dyslipidemia reached a real long-term RRR of all-cause mortality. They had by definition a need for this programme.

Keywords
All-cause mortality, dyslipidemia, intervention, secondary prevention
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-42844 (URN)10.1097/HJR.0b013e32833a65cc (DOI)20700054 (PubMedID)
Available from: 2011-04-14 Created: 2011-04-14 Last updated: 2018-06-08Bibliographically approved
Tinghög, P., Carstensen, J., Kaati, G., Edvinsson, S., Sjöström, M. & Bygren, L. O. (2011). Migration and mortality trajectories: a study of individuals born in the rural community of Överkalix, Sweden. Social Science and Medicine, 73(5), 744-751
Open this publication in new window or tab >>Migration and mortality trajectories: a study of individuals born in the rural community of Överkalix, Sweden
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2011 (English)In: Social Science and Medicine, ISSN 0277-9536, E-ISSN 1873-5347, Vol. 73, no 5, p. 744-751Article in journal (Refereed) Published
Abstract [en]

Migration may result in exposure to factors that are both beneficial and harmful for good health. How the act of migration is associated with mortality, or whether the socio-economic condition of migrants prior to migration influences their mortality trajectory, is not well understood. In the present study, a cohort of 413 randomly selected individuals born in the rural community of Överkalix, Sweden, between 1890 and 1935 were followed from birth to either death or old age. Around 50% of the study-population moved away from Överkalix at one time or another. To adjust for a potential bias resulting from self-selection among the migrants, the father’s occupational status was used together with parents’ and grandparents’ longevity. Overall, migration could not be shown to predict mortality when the backgrounds of the migrants were taken into account. Nonetheless, socio-economic background conditions appeared to moderate the association, decreasing the mortality rates for migrants with relatively good pre-migratory socio-economic conditions, while increasing it for migrants with poorer pre-migratory conditions. However, further scrutiny revealed that this effect modification mainly affected the female migrants’ mortality. In conclusion, the study suggests that there is no general association between migration and mortality, but that migrants with better socio-economic resources are more likely to improve their mortality trajectories than migrants with poorer resources. Better pre-migratory conditions hence appear to be important for avoiding health-adverse circumstances and gaining access to health beneficial living conditions when moving to foreign environments – especially for women.

Place, publisher, year, edition, pages
Oxford: Elsevier, 2011
Keywords
Sweden, migration, mortality, trajectory, pre-migration conditions, self-selection, industrialisation, urbanisation
National Category
Public Health, Global Health, Social Medicine and Epidemiology Occupational Health and Environmental Health
Research subject
Social Medicine; Epidemiology
Identifiers
urn:nbn:se:umu:diva-45750 (URN)10.1016/j.socscimed.2011.06.055 (DOI)
Available from: 2011-08-16 Created: 2011-08-16 Last updated: 2018-06-08Bibliographically approved
Bygren, L. O., Weissglass, G., Wikström, B.-M., Benson Konlaan, B., Grjibovski, A., Karlsson, A.-B., . . . Sjöström, M. (2009). Cultural participation and health: a randomized controlled trial among medical care staff.. Psychosomatic Medicine, 71(May), 469-473
Open this publication in new window or tab >>Cultural participation and health: a randomized controlled trial among medical care staff.
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2009 (English)In: Psychosomatic Medicine, ISSN 0033-3174, E-ISSN 1534-7796, Vol. 71, no May, p. 469-473Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Wolters Kluwer, 2009
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-22840 (URN)10.1097/PSY.0b013e31819e47d4 (DOI)881251 (Local ID)881251 (Archive number)881251 (OAI)
Available from: 2009-05-19 Created: 2009-05-19 Last updated: 2019-02-15Bibliographically approved
Kaati, G., Bygren, L. O., Pembrey, M. & Sjöstrom, M. (2007). Transgenerational response to nutrition, early life circumstances and longevity. European Journal of Human Genetics, 15(7), 784-790
Open this publication in new window or tab >>Transgenerational response to nutrition, early life circumstances and longevity
2007 (English)In: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 15, no 7, p. 784-790Article in journal (Refereed) Published
Abstract [en]

Nutrition might induce, at some loci, epigenetic or other changes that could be transmitted to the next generation impacting on health. The slow growth period (SGP) before the prepubertal peak in growth velocity has emerged as a sensitive period where different food availability is followed by different transgenerational response (TGR). The aim of this study is to investigate to what extent the probands own childhood circumstances are in fact the determinants of the findings. In the analysis, data from three random samples, comprising 271 probands and their 1626 parents and grandparents, left after exclusions because of missing data, were utilized. The availability of food during any given year was classified based on regional statistics. The ancestors' SGP was set at the ages of 8-12 years and the availability of food during these years classified as good, intermediate or poor. The probands' childhood circumstances were defined by the father's ownership of land, the number of siblings and order in the sibship, the death of parents and the parents' level of literacy. An earlier finding of a sex-specific influence from the ancestors' nutrition during the SGP, going from the paternal grandmother to the female proband and from the paternal grandfather to the male proband, was confirmed. In addition, a response from father to son emerged when childhood social circumstances of the son were accounted for. Early social circumstances influenced longevity for the male proband. TGRs to ancestors' nutrition prevailed as the main influence on longevity.

Place, publisher, year, edition, pages
London: Nature Publishing Group, 2007
Keywords
early life, social environment, food availability, sex-specific transgenerational responses, mortality
National Category
Biochemistry and Molecular Biology Medical Genetics
Identifiers
urn:nbn:se:umu:diva-118203 (URN)10.1038/sj.ejhg.5201832 (DOI)000247436300012 ()17457370 (PubMedID)
Available from: 2016-04-11 Created: 2016-03-14 Last updated: 2018-06-07Bibliographically approved
Bygren, L. O., Kaati, G., Edvinsson, S. & Pembrey, M. E. (2006). Epigenetics or ephemeral genetics?: Reply to Senn. Nature publishing group, 14(11)
Open this publication in new window or tab >>Epigenetics or ephemeral genetics?: Reply to Senn
2006 (English)Other (Other academic)
Place, publisher, year, pages
Nature publishing group, 2006
Identifiers
urn:nbn:se:umu:diva-36039 (URN)10.1038/sj.ejhg.5201685 (DOI)
Note
Letter, European Journal of Human Genetics (2006) 14, 1149–1150. Published online 12 July 2006.Available from: 2010-09-15 Created: 2010-09-15 Last updated: 2018-06-08Bibliographically approved
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