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Publications (10 of 37) Show all publications
Abdelrahman, K. N., Abdel Ghany, A. G., Saber, R. A., Osman, A., Sitohy, B. & Sitohy, M. (2024). Anthocyanins from pomegranate peel (Punica granatum), chili pepper fruit (Capsicum annuum), and bougainvillea flowers (Bougainvillea spectabilis) with multiple biofunctions: antibacterial, antioxidant, and anticancer. Heliyon, 10(11), Article ID e32222.
Open this publication in new window or tab >>Anthocyanins from pomegranate peel (Punica granatum), chili pepper fruit (Capsicum annuum), and bougainvillea flowers (Bougainvillea spectabilis) with multiple biofunctions: antibacterial, antioxidant, and anticancer
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2024 (English)In: Heliyon, E-ISSN 2405-8440, Vol. 10, no 11, article id e32222Article in journal (Refereed) Published
Abstract [en]

Background: Natural colorants, including natural pigments, e.g., anthocyanins, carotenoids, and chlorophylls, in novel and attractive food matrixes have become a popular trend. They impart favorite colors to food products and provide significant therapeutic effects. This study is aimed at extracting and identifying some natural pigments from different plant sources and evaluating their ability as antibacterial, antioxidant, and anticancer activities.

Methods: The anthocyanin-rich extract (ARE) is derived from three natural plant sources: pomegranate peel (Punica granatum), chili pepper fruit (Capsicum annuum), and Bougainvillea flowers. Bougainvillea spectabilis are analyzed for biochemical composition, as well as antioxidant, antibacterial, and anticancer activity, HPLC, DPPH, FRAP, disc diffusion assay, MIC, MTT, VEGFR‐2, and caspase-9 assays.

Results: All three extracts had varying total phenolic contents, ranging from 14 to 466 mg GAE/g extract, where Punica granatum was the highest (466 mg GAE/g extract), followed by Bougainvillea spectabilis (180 mg GAE/g extract), and then Capsicum annuum (14 mg GAE/g extract). The antioxidant activity rose steadily with raising concentration. The ARE of pomegranate peels recorded highest value, followed by Bougainvillea flowers and chili pepper fruit. The MTT assay revealed an inhibitory action of the tested extracts on the proliferation of HCT-116, MCF-7, and HepG2 in a concentration-based manner. Gene expression of caspase-9 transcripts was considerably multiplied by the application of ARE of pomegranate peels. All the tested extracts inhibited VEGFR-2, and the inhibition (%) expanded gradually with increasing concentrations, achieving the highest value (80 %) at 10 μg/mL. The ARE of pomegranate peels scored highest antibacterial activity, followed by ARE of chili pepper fruit and Bougainvillea flowers. The inhibition zone diameter escalated gradually with rising concentrations of the tested samples.

Conclusion: The AREs of the three studied plant sources can be used as multifunctional products with antioxidant, anticancer, and antibacterial activities that are natural, safe, and cheap.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
Anthocyanin, Bougainvillea spectabilis, Capsicum annuum, DPPH-Assay, MTT-Assay, Phenolics, Punica granatum
National Category
Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-225849 (URN)10.1016/j.heliyon.2024.e32222 (DOI)2-s2.0-85194583004 (Scopus ID)
Funder
Region VästerbottenThe Kempe Foundations
Available from: 2024-06-14 Created: 2024-06-14 Last updated: 2024-06-14Bibliographically approved
Shindia, A., Abdel-Shafi, S., Atef, A., Osman, A., Sitohy, B. & Sitohy, M. (2024). Antibacterial activity of carrot peel HCl-ethanol extracts and its potential application in meat preservation. Lebensmittel-Wissenschaft + Technologie, 207, Article ID 116638.
Open this publication in new window or tab >>Antibacterial activity of carrot peel HCl-ethanol extracts and its potential application in meat preservation
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2024 (English)In: Lebensmittel-Wissenschaft + Technologie, ISSN 0023-6438, E-ISSN 1096-1127, Vol. 207, article id 116638Article, review/survey (Refereed) Published
Abstract [en]

Natural plant extracts have been employed extensively in food products due to their antioxidant and antimicrobial activity. Ethanolic extracts of four selected vegetable peels, (kiwi, carrot, sweet potato and eggplant) in addition to red pepper fruit were evaluated for their polyphenolic contents, showing carrot peel extract (CPE) having the highest levels of phenolics and flavonoids. CPE exhibited a strong antioxidant activity (88.81% oxidation inhibition at 500 μg/mL), via scavenging 2, 2-Diphenyl-1-picrylhydrazyl (DPPH). The five extracts showed antibacterial activities against two Gram-positive (Staphylococcus aureus, Bacillus cereus) and two Gram-negative (Salmonella typhi, Escherichia coli) bacteria, where CPE proved the most effective antibacterial, with a minimal inhibitory concentration of 20 μg/mL, without any bacterial resistance. Adding CPE to ciprofloxacin (CIP) (1:1) showed a combination effect. HPLC of CPE revealed its inclusion of β-carotene pigment (1.5 mg/g) and a great number of flavonoid and phenolic compounds, capable to act as antimicrobial agents. Ground meatsamples supplemented with 40 and 100 μg/g of CPE reduced their total viable, coliforms and Psychrotrophs count and extended their shelf life at 4 °C to 12 days. So, CPE can be safely used as a natural preservative that can also maintain the sensory properties of stored meat product.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
Antibacterial, Antioxidant, Carrot, Extract, Meat
National Category
Organic Chemistry
Identifiers
urn:nbn:se:umu:diva-228803 (URN)10.1016/j.lwt.2024.116638 (DOI)2-s2.0-85201257587 (Scopus ID)
Funder
Lions Cancerforskningsfond i NorrThe Kempe Foundations
Available from: 2024-08-26 Created: 2024-08-26 Last updated: 2024-08-26Bibliographically approved
Eltorky, H., AbdelMageed, M., Ismail, H., Zahran, F., Guirgis, A., Ohlsson, L., . . . Sitohy, B. (2024). LGR6 is a prognostic biomarker for less differentiated tumors in lymph nodes of colon cancer patients. Frontiers in Oncology, 14, Article ID 1393075.
Open this publication in new window or tab >>LGR6 is a prognostic biomarker for less differentiated tumors in lymph nodes of colon cancer patients
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2024 (English)In: Frontiers in Oncology, E-ISSN 2234-943X, Vol. 14, article id 1393075Article in journal (Refereed) Published
Abstract [en]

Introduction: The aim was to investigate whether the stem cell marker LGR6 has prognostic value in colon cancer, alone or in combination with the prognostic biomarkers CEA and CXCL16.

Methods: LGR6 mRNA levels were determined in 370 half lymph nodes of 121 colon cancer patients. Ability to predict relapse after curative surgery was estimated by Kaplan-Meier survival model and Cox regression analyses.

Results: Patients with high LGR6 levels [LGR6(+)] had a decreased mean survival time of 11 months at 5-year follow-up and 47 months at 12-year follow-up, respectively, with hazard ratios of 3.2 and 2.8. LGR6 mRNA analysis added prognostic value to CEA and CXCL16 mRNA analysis. In the poor prognosis groups CEA(+) and CXCL16(+), further division was achieved by LGR6 analysis. LGR6(+) patients had a very poor prognosis. LGR6 also identified a small number of CEA(-), TNM stage I patients who relapsed suggesting stem cell origin of these tumors. LGR6 and LGR5 levels correlated strongly in lymph nodes of stage I and IV patients but not in stage II patients, suggesting that these stem cell markers are differentially regulated.

Conclusion: This study highlights LGR6 as a useful prognostic biomarker independently and in combination with CEA, CXCL16 or LGR5 identifying different risk groups.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2024
Keywords
cancer stem cells, CEA, colon cancer, CXCL16, LGR5, LGR6, qRT-PCR, regional lymph nodes
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-224262 (URN)10.3389/fonc.2024.1393075 (DOI)2-s2.0-85192206246 (Scopus ID)
Funder
Swedish Research Council, 2008-7042Swedish Research Council, 2010-05669Swedish Research Council, 2013-04522Region Västerbotten, RV-995803The Kempe Foundations, JCK22-0003
Available from: 2024-05-14 Created: 2024-05-14 Last updated: 2024-05-14Bibliographically approved
Sitohy, M., Enan, G., Abdel-Shafi, S., El-Wafa, N. A., El-Gazzar, N., Osman, A. & Sitohy, B. (2024). Mapping pathogenic bacteria resistance against common antibiotics and their potential susceptibility to methylated white kidney bean protein. BMC Microbiology, 24(1), Article ID 49.
Open this publication in new window or tab >>Mapping pathogenic bacteria resistance against common antibiotics and their potential susceptibility to methylated white kidney bean protein
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2024 (English)In: BMC Microbiology, E-ISSN 1471-2180, Vol. 24, no 1, article id 49Article in journal (Refereed) Published
Abstract [en]

As antibiotics cannot inhibit multidrug-resistant bacteria (MDR), continuous research is mandatory to find other antibacterials from natural resources. Native legume proteins and their modified forms exhibited broad spectra of high antimicrobial activities. Sixteen bacterial isolates were mapped for antibiotic resistance, showing resistance in the range of (58-92%) and (42-92%) in the case of the Gram-negative and Gram-positive bacteria, respectively. White native Phaseolus vulgaris protein (NPP) was isolated from the seeds and methylated (MPP). The MIC range of MPP against 7 MDR bacteria was 10-25 times lower than NPP and could (1 MIC) considerably inhibit their 24 h liquid growth. MPP showed higher antibacterial effectiveness than Gentamycin, the most effective antibiotic against Gram-positive bacteria and the second most effective against Gram-negative bacteria. However, MPP recorded MICs against the seven studied MDR bacteria in the 1-20 µg/mL range, the same for Gentamycin. The combination of Gentamycin and MPP produced synergistic effects against the seven bacteria studied, as confirmed by the Transmission Electron Microscopic images. The antimicrobial activity of MPP against the seven MDR bacteria remained stable after two years of cold storage at 8-10 °C as contrasted to Gentamycin, which lost 20-72% of its antimicrobial effectiveness.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2024
Keywords
Antibiotic effectiveness, AST, FTIR, MDR, Methylated protein
National Category
Microbiology
Identifiers
urn:nbn:se:umu:diva-221117 (URN)10.1186/s12866-024-03202-x (DOI)001156907800001 ()38317090 (PubMedID)2-s2.0-85184421295 (Scopus ID)
Funder
Region VästerbottenThe Kempe FoundationsLions Cancerforskningsfond i Norr
Available from: 2024-02-23 Created: 2024-02-23 Last updated: 2024-02-23Bibliographically approved
El-Didamony, S. E., Kalaba, M. H., Sharaf, M. H., El-Fakharany, E. M., Khalil, A. O., Sitohy, M. & Sitohy, B. (2024). Melittin alcalase-hydrolysate: a novel chemically characterized multifunctional bioagent; antibacterial, anti-biofilm and anticancer. Frontiers in Microbiology, 15, Article ID 1419917.
Open this publication in new window or tab >>Melittin alcalase-hydrolysate: a novel chemically characterized multifunctional bioagent; antibacterial, anti-biofilm and anticancer
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2024 (English)In: Frontiers in Microbiology, E-ISSN 1664-302X, Vol. 15, article id 1419917Article in journal (Refereed) Published
Abstract [en]

The prevalent life-threatening microbial and cancer diseases and lack of effective pharmaceutical therapies created the need for new molecules with antimicrobial and anticancer potential. Bee venom (BV) was collected from honeybee workers, and melittin (NM) was extracted from BV and analyzed by urea-polyacrylamide gel electrophoresis (urea-PAGE). The isolated melittin was hydrolyzed with alcalase into new bioactive peptides and evaluated for their antimicrobial and anticancer activity. Gel filtration chromatography fractionated melittin hydrolysate (HM) into three significant fractions (F1, F2, and F3), that were characterized by electrospray ionization mass spectrometry (ESI-MS) and evaluated for their antimicrobial, anti-biofilm, antitumor, and anti-migration activities. All the tested peptides showed antimicrobial and anti-biofilm activities against Gram-positive and Gram-negative bacteria. Melittin and its fractions significantly inhibited the proliferation of two types of cancer cells (Huh-7 and HCT 116). Yet, melittin and its fractions did not affect the viability of normal human lung Wi-38 cells. The IC50 and selectivity index data evidenced the superiority of melittin peptide fractions over intact melittin. Melittin enzymatic hydrolysate is a promising novel product with high potential as an antibacterial and anticancer agent.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2024
Keywords
antibacterial activity, anticancer activity, Apis mellifera, bee venom, electro-spray ionization, enzymatic hydrolysis, melittin, wound healing assay
National Category
Biochemistry and Molecular Biology Physical Chemistry
Identifiers
urn:nbn:se:umu:diva-228425 (URN)10.3389/fmicb.2024.1419917 (DOI)001282524700001 ()39091304 (PubMedID)2-s2.0-85200235378 (Scopus ID)
Funder
Region VästerbottenLions Cancerforskningsfond i NorrThe Kempe Foundations
Available from: 2024-08-15 Created: 2024-08-15 Last updated: 2024-08-15Bibliographically approved
Lindmark, G., Olsson, L., Sitohy, B., Israelsson, A., Blomqvist, J., Kero, S., . . . Hammarström, M.-L. (2024). qRT-PCR analysis of CEACAM5, KLK6, SLC35D3, MUC2 and POSTN in colon cancer lymph nodes: An improved method for assessment of tumor stage and prognosis. International Journal of Cancer, 154(3), 573-584
Open this publication in new window or tab >>qRT-PCR analysis of CEACAM5, KLK6, SLC35D3, MUC2 and POSTN in colon cancer lymph nodes: An improved method for assessment of tumor stage and prognosis
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2024 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 154, no 3, p. 573-584Article in journal (Refereed) Published
Abstract [en]

One fourth of colorectal cancer patients having curative surgery will relapse of which the majority will die. Lymph node (LN) metastasis is the single most important prognostic factor and a key factor when deciding on postoperative treatment. Presently, LN metastases are identified by histopathological examination, a subjective method analyzing only a small LN volume and giving no information on tumor aggressiveness. To better identify patients at risk of relapse we constructed a qRT-PCR test, ColoNode, that determines levels of CEACAM5, KLK6, SLC35D3, MUC2 and POSTN mRNAs. Combined these biomarkers estimate the tumor cell load and aggressiveness allocating patients to risk categories with low (0, −1), medium (1), high (2) and very high (3) risk of recurrence. Here we present result of a prospective, national multicenter study including 196 colon cancer patients from 8 hospitals. On average, 21 LNs/patient, totally 4698 LNs, were examined by both histopathology and ColoNode. At 3-year follow-up, 36 patients had died from colon cancer or lived with recurrence. ColoNode identified all patients that were identified by histopathology and in addition 9 patients who were undetected by histopathology. Thus, 25% of the patients who recurred were identified by ColoNode only. Multivariate Cox regression analysis proved ColoNode (1, 2, 3 vs 0, −1) as a highly significant risk factor with HR 4.24 [95% confidence interval, 1.42-12.69, P =.01], while pTN-stage (III vs I/II) lost its univariate significance. In conclusion, ColoNode surpassed histopathology by identifying a significantly larger number of patients with future relapse and will be a valuable tool for decisions on postoperative treatment.

Place, publisher, year, edition, pages
John Wiley & Sons, 2024
Keywords
colon cancer, ColoNode, lymph nodes, prognosis, tumor markers
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-214620 (URN)10.1002/ijc.34718 (DOI)001067494700001 ()37700602 (PubMedID)2-s2.0-85170666995 (Scopus ID)
Funder
Region VästerbottenSwedish Cancer SocietySwedish Research Council, 2017-00675The Kempe FoundationsUmeå UniversityVinnova
Available from: 2023-09-27 Created: 2023-09-27 Last updated: 2024-01-12Bibliographically approved
Hussain, N., Ikram, N., Khan, K. u., Hussain, L., Alqahtani, A. M., Alqahtani, T., . . . Sitohy, B. (2023). Cichorium intybus L. significantly alleviates cigarette smoke-induced acute lung injury by lowering NF-κB pathway activation and inflammatory mediators. Heliyon, 9(11), Article ID e22055.
Open this publication in new window or tab >>Cichorium intybus L. significantly alleviates cigarette smoke-induced acute lung injury by lowering NF-κB pathway activation and inflammatory mediators
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2023 (English)In: Heliyon, E-ISSN 2405-8440, Vol. 9, no 11, article id e22055Article in journal (Refereed) Published
Abstract [en]

Background: Cigarette smoke (CS) is one of the primary causes of acute lung injury (ALI) via provoking pulmonary inflammation and oxidative stress. Despite substantial studies, no effective treatment for ALI is presently available.

Purpose: New prospective treatment options for ALI are required. Thus, this project was designed to investigate the in vivo and in vitro protective effects of 70 % methanolic-aqueous crude extract of whole plant of Cichorium intybus (Ci.Mce) against CS-induced ALI.

Study design: /methods: Initially, male Swiss albino mice were subjected to whole-body CS exposure for 10 continuous days to prepare CS-induced ALI models. Normal saline (10 mL/kg), Ci.Mce (100, 200, 300 mg/kg), and Dexamethasone (1 mg/kg) were orally administered to respective animal groups 1 h prior to CS-exposure. 24 hrs after the last CS-exposure, BALF and lungs were harvested to study the key characteristics of ALI. Next, HPLC analysis was done to explore the phytoconstituents.

Results: Ci.Mce exhibited significant reductions in lung macrophage and neutrophil infiltration, lung weight coefficient, and albumin exudation. Additionally, it effectively ameliorated lung histopathological alterations and hypoxemia. Notably, Ci.Mce exerted inhibitory effects on the excessive generation of IL-6, IL-1β, and KC in both CS-induced ALI murine models and CSE-stimulated RAW 264.7 macrophages. Noteworthy benefits included the attenuation of oxidative stress induced by CS, evidenced by decreased levels of MDA, TOS, and MPO, alongside enhanced TAC production. Furthermore, Ci.Mce demonstrated a marked reduction in CS-induced NF-κB expression, both in vivo and in vitro.

Conclusion: Consequently, Cichorium intybus could be a therapeutic option for CS-induced ALI due to its ability to suppress inflammatory reactions, mitigate oxidative stress, and quell NF-κB p65 activation.

Place, publisher, year, edition, pages
Elsevier, 2023
Keywords
ALI, IL-1β, IL-6, MPO, NF-κB p65, TOS
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:umu:diva-220858 (URN)10.1016/j.heliyon.2023.e22055 (DOI)001123642900001 ()38045213 (PubMedID)2-s2.0-85183786410 (Scopus ID)
Funder
Region VästerbottenCancerforskningsfonden i NorrlandLions Cancerforskningsfond i NorrThe Kempe Foundations
Available from: 2024-02-19 Created: 2024-02-19 Last updated: 2024-02-19Bibliographically approved
Enan, G., Abdel-Shafi, S., El-Nemr, M., Shehab, W., Osman, A., Sitohy, M. & Sitohy, B. (2023). Controlling bacterial biofilm formation by native and methylated lupine 11S globulins. Frontiers in Microbiology, 14, Article ID 1259334.
Open this publication in new window or tab >>Controlling bacterial biofilm formation by native and methylated lupine 11S globulins
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2023 (English)In: Frontiers in Microbiology, E-ISSN 1664-302X, Vol. 14, article id 1259334Article in journal (Refereed) Published
Abstract [en]

The antibacterial and anti-biofilm activities of the 11S globulins isolated from lupin seeds (Lupinus termis), and its methylated derivative (M11S), were investigated against seven pathogenic gram-positive and gram-negative bacteria. The MIC of 11S ranged from 0.1 to 4.0 μg/ml against 0.025 to 0.50 μg/ml for M11S, excelling some specific antibiotics. The MICs of M11S were 40–80 times lower than some specific antibiotics against gram-positive bacteria and 2–60 times lower than some specific antibiotics against gram-negative bacteria. One MIC of 11S and M11S highly reduced the liquid growth of all tested bacteria during 24 h at 37°C. They also inhibited biofilm formation by 80%−86% and 85%−94%, respectively (gram-positive), and 29%−44% and 43%−50%, respectively (gram-negative). M11S prevented biofilm formation by gram-positive bacteria at minimum biofilm inhibitory concentration (MBIC), 0.025–0.1 μg/ml against 0.1–0.5 μg/ml for gram-negative bacteria, i.e., 4–20 times and 4–7 times anti-biofilm inhibitory action compared with 11S, respectively. Biofilm formation of two bacteria revealed no adhered cells on glass slides for 24 h at 37°C, i.e., was entirely prevented by one MBIC of 11S and M11S. Scanning electron microscopy indicated microbial biofilm deformation under the action of 11S and M11S, indicating their broad specificity and cell membrane-targeted action.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2023
Keywords
11S globulin, antibiofilm activity, FTIR, methylated, pathogenic bacteria
National Category
Microbiology Microbiology in the medical area
Identifiers
urn:nbn:se:umu:diva-215733 (URN)10.3389/fmicb.2023.1259334 (DOI)001080608600001 ()37822740 (PubMedID)2-s2.0-85173759258 (Scopus ID)
Funder
Region VästerbottenThe Kempe Foundations
Available from: 2023-11-03 Created: 2023-11-03 Last updated: 2024-01-17Bibliographically approved
Ali, H., AbdelMageed, M., Ohlsson, L., Lindmark, G., Hammarström, M.-L., Hammarström, S. & Sitohy, B. (2023). Detection of lymph node metastasis in colon cancer by ectopically expressed fibroblast markers FOXQ1 and THBS2. Frontiers in Oncology, 13, Article ID 1297324.
Open this publication in new window or tab >>Detection of lymph node metastasis in colon cancer by ectopically expressed fibroblast markers FOXQ1 and THBS2
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2023 (English)In: Frontiers in Oncology, E-ISSN 2234-943X, Vol. 13, article id 1297324Article in journal (Refereed) Published
Abstract [en]

Introduction: Approximately 25% of colon cancer (CC) patients having curative surgery will relapse. Therefore, it is crucial to identify patients with increased recurrence risk to offer them adjuvant chemotherapy. Three markers with prominent expression in fibroblasts: forkhead box Q1 (FOXQ1), matrix metalloproteinase-11 (MMP11), and thrombospondin-2 (THBS2), and the fibroblast expressed chemokine CXCL12 were selected for studies because of the critical role of fibroblasts in the microenvironment of the tumor.

Methods: The expression levels of the biomarkers were assessed in primary CC tumors, lymph nodes of CC patients and controls, and CC cell lines at mRNA and protein levels by real-time qRT-PCR and immunohistochemistry, respectively.

Results: FOXQ1, MMP11, and THBS2 mRNAs were expressed at significantly higher levels in primary tumors compared to normal colon (P=0.002, P<0.0001, and P<0.0001, respectively). In contrast, CXCL12 mRNA levels were higher in normal colon tissue. FOXQ1, MMP11, and THBS2 levels were also expressed at significantly higher levels in metastasis-positive lymph nodes compared to both metastasis-negative- and control nodes (P<0.0001/P=0.002, P<0.0001/P<0.0001, and P<0.0001/P<0.0001, respectively). Immuno-morphometry revealed that 30–40% of the tumor cells expressed FOXQ1, MMP11, and THBS2. FOXQ1 and THBS2 were barely detected in normal colon epithelium (P<0.0001), while MMP11 was expressed in normal colon epithelium at high levels.

Discussion: We conclude that CC tumor cells show ectopic expression of FOXQ1 and THBS2 possibly making these tumor cells independent of fibroblast cell support. The high expression levels of these two biomarkers in metastatic lymph nodes suggest that they are potential indicators of patients at risk for recurrence.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2023
Keywords
colon cancer, CXCL12, fibroblasts, FOXQ1, immunohistochemistry, MMP11, qRT-PCR, THBS2
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-219081 (URN)10.3389/fonc.2023.1297324 (DOI)2-s2.0-85180658536 (Scopus ID)
Funder
Swedish Research Council, 2010-05669Swedish Research Council, 2013-04522Umeå UniversityRegion VästerbottenThe Kempe Foundations
Available from: 2024-01-11 Created: 2024-01-11 Last updated: 2024-01-17Bibliographically approved
El-Saadony, M. T., Yang, T., Korma, S. A., Sitohy, M., Abd El-Mageed, T. A., Selim, S., . . . Saad, A. M. (2023). Impacts of turmeric and its principal bioactive curcumin on human health: pharmaceutical, medicinal, and food applications: a comprehensive review. Frontiers in Nutrition, 9, Article ID 1040259.
Open this publication in new window or tab >>Impacts of turmeric and its principal bioactive curcumin on human health: pharmaceutical, medicinal, and food applications: a comprehensive review
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2023 (English)In: Frontiers in Nutrition, E-ISSN 2296-861X, Vol. 9, article id 1040259Article, review/survey (Refereed) Published
Abstract [en]

The yellow polyphenolic pigment known as curcumin, originating from the rhizome of the turmeric plant Curcuma longa L., has been utilized for ages in ancient medicine, as well as in cooking and food coloring. Recently, the biological activities of turmeric and curcumin have been thoroughly investigated. The studies mainly focused on their antioxidant, antitumor, anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective impacts. This review seeks to provide an in-depth, detailed discussion of curcumin usage within the food processing industries and its effect on health support and disease prevention. Curcumin’s bioavailability, bio-efficacy, and bio-safety characteristics, as well as its side effects and quality standards, are also discussed. Finally, curcumin’s multifaceted uses, food appeal enhancement, agro-industrial techniques counteracting its instability and low bioavailability, nanotechnology and focused drug delivery systems to increase its bioavailability, and prospective clinical use tactics are all discussed.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2023
Keywords
bioavailability, cancer, curcumin, dietary additives, herbal treatment, metabolism, polyphenolic pigment
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:umu:diva-204672 (URN)10.3389/fnut.2022.1040259 (DOI)000920918600001 ()36712505 (PubMedID)2-s2.0-85147150012 (Scopus ID)
Available from: 2023-02-10 Created: 2023-02-10 Last updated: 2023-09-05Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0001-8803-4798

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