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van Guelpen, BethanyORCID iD iconorcid.org/0000-0002-9692-101X
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Publications (10 of 181) Show all publications
Lee, M. A., Hatcher, C. A., Hazelwood, E., Goudswaard, L. J., Tsilidis, K. K., Vincent, E. E., . . . Murphy, N. (2025). A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator. International Journal of Epidemiology, 54(1), Article ID dyae175.
Open this publication in new window or tab >>A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator
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2025 (English)In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 54, no 1, article id dyae175Article in journal (Refereed) Published
Abstract [en]

Background: Adiposity is an established risk factor for colorectal cancer (CRC). The pathways underlying this relationship, and specifically the role of circulating proteins, are unclear.

Methods: Utilizing two-sample univariable Mendelian randomization (UVMR), multivariable Mendelian randomization (MVMR), and colocalization, based on summary data from large sex-combined and sex-specific genetic studies, we estimated the univariable associations between: (i) body mass index (BMI) and waist–hip ratio (WHR) and overall and site-specific (colon, proximal colon, distal colon, and rectal) CRC risk, (ii) BMI and WHR and circulating proteins, and (iii) adiposity-associated circulating proteins and CRC risk. We used MVMR to investigate the potential mediating role of adiposity- and CRC-related circulating proteins in the adiposity–CRC association.

Results: BMI and WHR were positively associated with CRC risk, with similar associations by anatomical tumor site. In total, 6591 adiposity–protein (2628 unique circulating proteins) and 33 protein–CRC (7 unique circulating proteins) associations were identified using UVMR and colocalization. One circulating protein, GREM1, was associated with BMI (only) and CRC outcomes in a manner that was consistent with a potential mediating role in sex-combined and female-specific analyses. In MVMR, adjusting the BMI–CRC association for GREM1, effect estimates were attenuated—suggestive of a potential mediating role—most strongly for the BMI–overall CRC association in women.

Conclusion: Results highlight the impact of adiposity on the plasma proteome and of adiposity-associated circulating proteins on the risk of CRC. Supported by evidence from UVMR and colocalization analyses using cis-single-nucleotide polymorphisms, GREM1 was identified as a potential mediator of the BMI–CRC association, particularly in women.

Place, publisher, year, edition, pages
Oxford University Press, 2025
Keywords
adiposity, colocalization, colorectal cancer, Mendelian randomization, proteome
National Category
Public Health, Global Health and Social Medicine Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-236120 (URN)10.1093/ije/dyae175 (DOI)001402221300001 ()39846783 (PubMedID)2-s2.0-85216460770 (Scopus ID)
Funder
Swedish Cancer Society, 21 0467 FE 01 HSwedish Cancer Society, 20 1154 PjF
Available from: 2025-03-07 Created: 2025-03-07 Last updated: 2025-03-07Bibliographically approved
Alduhayh, S., Laskar, R. S., Jiang, X., Zhu, Z., Vincent, E. E., Constantinescu, A.-E., . . . Dimou, N. (2025). Association of genetic liability to allergic diseases with overall and early-onset colorectal cancer risk: a mendelian randomization study. Cancer Epidemiology, Biomarkers and Prevention, 34(5), 722-736
Open this publication in new window or tab >>Association of genetic liability to allergic diseases with overall and early-onset colorectal cancer risk: a mendelian randomization study
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2025 (English)In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 34, no 5, p. 722-736Article in journal (Refereed) Published
Abstract [en]

Background: The tumor immunosurveillance theory supports that allergic conditions could decrease cancer risk. However, observational evidence yielded inconsistent results for the association between allergic diseases and colorectal cancer risk. We used Mendelian randomization (MR) to examine potential causal associations of allergies with the risk of overall and early-onset colorectal cancer.

Methods: Genome-wide association study summary statistical data were used to identify genetic variants associated with allergic diseases (Nvariants = 65) and individual allergic conditions (asthma, hay fever/allergic rhinitis, and eczema). Using twosample MR, we examined these variants in relation to incident overall (Ncases = 52,775 cases) and early-onset colorectal cancer (Ncases = 6,176). The mediating role of white blood cells was examined using multivariable MR.

Results: In inverse-variance-weighted models, genetic liability to allergic diseases was inversely associated with overall {OR per log (odds) = 0.90 [95% confidence interval (CI), 0.85-0.96]; P < 0.01} and early-onset colorectal cancer [OR = 0.83 (95% CI, 0.73-0.95); P = 0.01]. Similar inverse associations were found for hay fever/allergic rhinitis or eczema, whereas no evidence of association was found between liability to asthma-related phenotypes and colorectal cancer risk. Multivariable MR adjustment for eosinophils weakened the inverse associations for liability to allergic diseases for overall [OR = 0.96 (95% CI, 0.89-1.03); P = 0.26] and early-onset colorectal cancer [OR = 0.86 (95% CI, 0.73-1.01); P = 0.06].

Conclusions: Our study supports a potential causal association between liability to allergic diseases, specifically hay fever/allergic rhinitis or eczema, and colorectal cancer, possibly at least in part mediated via eosinophil counts.

Impact: Our results provide evidence that allergic responses may also have a role in immunosurveillance against colorectal cancer.

Place, publisher, year, edition, pages
American Association For Cancer Research (AACR), 2025
National Category
Medical Genetics and Genomics
Identifiers
urn:nbn:se:umu:diva-238730 (URN)10.1158/1055-9965.EPI-24-0970 (DOI)39982694 (PubMedID)2-s2.0-105004370569 (Scopus ID)
Funder
Region VästerbottenGerman Research Foundation (DFG)Region SkåneSwedish Cancer SocietySwedish Research CouncilUmeå University
Available from: 2025-05-13 Created: 2025-05-13 Last updated: 2025-05-13Bibliographically approved
Späth, F., Wennberg, P., Johansson, R., Weinehall, L., Norberg, M., Rosén, A., . . . van Guelpen, B. (2025). Cohort profile: the Northern Sweden health and disease study (NSHDS). International Journal of Epidemiology, 54(1), Article ID dyaf004.
Open this publication in new window or tab >>Cohort profile: the Northern Sweden health and disease study (NSHDS)
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2025 (English)In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 54, no 1, article id dyaf004Article in journal (Refereed) Published
Abstract [en]

Key features: 

  • The Northern Sweden Health and Disease Study (NSHDS) was initiated in the mid-1980s. The NSHDS is a population-based prospective longitudinal cohort comprising >140 000 participants in the two northernmost regions in Sweden, Norrbotten and Västerbotten, with >240 000 blood samples and 1.5 million person-years of follow-up.
  • The NSHDS includes three sub-cohorts: the Västerbotten Intervention Programme (VIP), the expanded Northern Sweden Monitoring of Trends and Determinants of Cardiovascular Disease (MONICA) Study, and the Mammography Screening Project (MSP). The VIP is both a community-based cardiometabolic intervention programme encouraging healthy lifestyle (targeting individuals 40, 50, and 60 years of age), and a corresponding research cohort. The MONICA is an observational study focusing on cardiovascular disease and its associated risk factors, recruiting individuals aged 25–74 years. The MSP recruited women attending mammography during 1995–2006. The NSHDS median participation age is 50 years (53% women).
  • Most participants contribute data on health, lifestyle, anthropometric measures, blood pressure, blood lipids, and glucose tolerance, along with research blood samples that are fractionated, frozen within an hour of collection, and stored at –80°C. Linkage to registries, clinical cohorts, and biological tissue archives facilitates studies of well-characterized participants (often combined with intervention studies).
  • Collaborations are encouraged. Additional information can be found at: info.brs@umu.se; https://www.umu.se/en/biobank
Place, publisher, year, edition, pages
Oxford University Press, 2025
Keywords
biobank, biomarkers, disease risk, lifestyle intervention, longitudinal cohort, NSHDS, population-based study, prospective blood samples, prospective cohort, risk factor
National Category
Epidemiology Public Health, Global Health and Social Medicine
Identifiers
urn:nbn:se:umu:diva-235871 (URN)10.1093/ije/dyaf004 (DOI)001413338400001 ()39899988 (PubMedID)2-s2.0-85217499001 (Scopus ID)
Funder
Region VästerbottenNorrbotten County CouncilSwedish Research Council, 2017-00650Cancerforskningsfonden i Norrland, AMP 24-1152 FSSwedish Society of MedicineBlodcancerförbundetThe Kempe FoundationsSwedish Cancer Society, 22 2206 FKSwedish Society for Medical Research (SSMF), SG-23-0168-B
Available from: 2025-02-24 Created: 2025-02-24 Last updated: 2025-02-24Bibliographically approved
Ugai, T., van Guelpen, B., Mucci, L. A. & Ogino, S. (2025). Enhancing existing tumour biobanks in European prospective cohort studies. The Lancet Regional Health: Europe, 53, Article ID 101293.
Open this publication in new window or tab >>Enhancing existing tumour biobanks in European prospective cohort studies
2025 (English)In: The Lancet Regional Health: Europe, E-ISSN 2666-7762, Vol. 53, article id 101293Article in journal, Editorial material (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2025
National Category
Medical Genetics and Genomics Basic Cancer Research Medical Bioinformatics and Systems Biology
Identifiers
urn:nbn:se:umu:diva-238448 (URN)10.1016/j.lanepe.2025.101293 (DOI)001466389800001 ()40255932 (PubMedID)2-s2.0-105001803340 (Scopus ID)
Available from: 2025-05-09 Created: 2025-05-09 Last updated: 2025-05-09Bibliographically approved
Prizment, A., Standafer, A., Qu, C., Beutel, K. M., Wang, S., Huang, W.-Y., . . . Pankratz, N. (2025). Functional variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are associated with increased risk of colorectal cancer. Human Molecular Genetics, 34(7), 617-625
Open this publication in new window or tab >>Functional variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are associated with increased risk of colorectal cancer
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2025 (English)In: Human Molecular Genetics, ISSN 0964-6906, E-ISSN 1460-2083, Vol. 34, no 7, p. 617-625Article in journal (Refereed) Published
Abstract [en]

Background: Individuals with cystic fibrosis (CF; a recessive disorder) have an increased risk of colorectal cancer (CRC). Evidence suggests individuals with a single CFTR variant may also have increased CRC risk.

Methods: Using population-based studies (GECCO, CORECT, CCFR, and ARIC; 53 785 CRC cases and 58 010 controls), we tested for an association between the most common CFTR variant (Phe508del) and CRC risk. For replication, we used whole exome sequencing data from UK Biobank (UKB; 5126 cases and 20 504 controls matched 4:1 based on genetic distance, age, and sex), and extended our analyses to all other heterozygous CFTR variants annotated as CF-causing.

Results: In our meta-analysis of GECCO-CORECT-CCFR-ARIC, the odds ratio (OR) for CRC risk associated with Phe508del was 1.11 (P = 0.010). In our UKB replication, the OR for CRC risk associated with Phe508del was 1.28 (P = 0.002). The sequencing data from UKB also revealed an association between the presence of any other single CF-causing variant (excluding Phe508del) and CRC risk (OR = 1.33; P = 0.030). When stratifying CFTR variants by functional class, class I variants (no protein produced) had a stronger association (OR = 1.77; p = 0.002), while class II variants (misfolding and retention of the protein in the endoplasmic reticulum) other than Phe508del (OR = 1.75; p = 0.107) had similar effect size as Phe508del, and variants in classes III-VI had non-significant ORs less than 1.0 and/or were not present in cases.

Conclusions: CF-causing heterozygous variants, especially class I variants, are associated with a modest but statistically significant increased CRC risk. More research is needed to explain the biology underlying these associations.

Place, publisher, year, edition, pages
Oxford University Press, 2025
Keywords
colorectal cancer, haploinsufficiency, heterozygous CFTR variants, rare variant burden test, whole exome sequencing data
National Category
Medical Genetics and Genomics
Identifiers
urn:nbn:se:umu:diva-237135 (URN)10.1093/hmg/ddaf007 (DOI)001397859600001 ()39825500 (PubMedID)2-s2.0-105001204478 (Scopus ID)
Available from: 2025-04-15 Created: 2025-04-15 Last updated: 2025-04-15Bibliographically approved
Bovinder Ylitalo, E., Vidman, L., Harlid, S. & van Guelpen, B. (2025). mRNA extracted from frozen buffy coat samples stored long term in tubes with no RNA preservative shows promise for downstream sequencing analyses. PLOS ONE, 20(3), Article ID e0318834.
Open this publication in new window or tab >>mRNA extracted from frozen buffy coat samples stored long term in tubes with no RNA preservative shows promise for downstream sequencing analyses
2025 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 20, no 3, article id e0318834Article in journal (Refereed) Published
Abstract [en]

Transcriptomics is an important OMICs method that is often unavailable in biobank research. Frozen blood samples are routinely collected and stored in medical biobanks, but transcriptional studies have been limited due to technical difficulties of extracting high-quality RNA from blood frozen in standard tubes (without RNA preservatives). We aimed to determine whether biobanked buffy coat samples stored at -80°C for up to 23 years could be successfully used for mRNA sequencing. We used a CryoXtract CXT 350 to remove frozen sample cores, which were immersed in RNA preservative during thawing prior to RNA extraction. RNA sequencing was then performed on extractions from pooled samples as well as from 23 buffy coat samples from prospective colorectal cancer cases and 23 matched controls included in the population-based, prospective Northern Sweden Health and Disease Study (NSHDS). For all samples, two library preparation methods were used (Illumina TruSeq Stranded mRNA poly-A selection and Illumina Stranded Total RNA with Ribo-Zero Globin). RNA yields of over 1 µg were obtained from the majority of NSHDS samples (mean = 2.57 µg), and over 92% of samples had RIN values of ≥ 6, indicating suitability for downstream analyses. In conclusion, we developed a method for successfully extracting and sequencing high-quality mRNA from frozen buffy coat samples stored long term in tubes with no RNA preservative.

Place, publisher, year, edition, pages
Public Library of Science (PLoS), 2025
National Category
Biochemistry Molecular Biology
Identifiers
urn:nbn:se:umu:diva-237153 (URN)10.1371/journal.pone.0318834 (DOI)001449696700013 ()40106499 (PubMedID)2-s2.0-105000259333 (Scopus ID)
Funder
Swedish Cancer Society, 20 1154 PjFCancerforskningsfonden i NorrlandKnut and Alice Wallenberg FoundationRegion Västerbotten, VLL-833291
Available from: 2025-04-15 Created: 2025-04-15 Last updated: 2025-04-15Bibliographically approved
Kämpe, A., Gudmundsson, S., Walsh, C. P., Lindblad-Toh, K., Johansson, Å., Clareborn, A., . . . Lappalainen, T. (2025). Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare. Nature Medicine, 31, 1730-1732
Open this publication in new window or tab >>Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare
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2025 (English)In: Nature Medicine, ISSN 1078-8956, E-ISSN 1546-170X, Vol. 31, p. 1730-1732Article in journal, Editorial material (Refereed) Published
Place, publisher, year, edition, pages
Springer Nature, 2025
National Category
Medical Genetics and Genomics Medical Bioinformatics and Systems Biology
Identifiers
urn:nbn:se:umu:diva-237578 (URN)10.1038/s41591-025-03631-9 (DOI)001459758800001 ()40186080 (PubMedID)2-s2.0-105001976929 (Scopus ID)
Funder
Swedish Research CouncilSwedish Society for Medical Research (SSMF)Knut and Alice Wallenberg FoundationVinnovaMedical Research Council of Southeast Sweden (FORSS)Region ÖstergötlandSwedish Cancer SocietyThe Swedish Brain FoundationSwedish Heart Lung FoundationRegion SkåneEU, European Research CouncilRegion StockholmSjöberg FoundationThe Cancer Research Funds of RadiumhemmetScience for Life Laboratory, SciLifeLabNIH (National Institutes of Health)Familjen Erling-Perssons StiftelseUppsala UniversityMrs. Berta Kamprad's Cancer FoundationGöran Gustafsson Foundation for Research in Natural Sciences and Medicine
Available from: 2025-04-25 Created: 2025-04-25 Last updated: 2025-07-11Bibliographically approved
Lu, S. S., Rutegård, M., Häggström, C., Gylfe, Å., Harlid, S. & van Guelpen, B. (2025). Prior antibiotics exposure is associated with an elevated risk of surgical site infections, including anastomotic leakage, after colon cancer but not rectal cancer surgery: A register-based study of 38,839 patients. International Journal of Cancer, 156(9), 1703-1715
Open this publication in new window or tab >>Prior antibiotics exposure is associated with an elevated risk of surgical site infections, including anastomotic leakage, after colon cancer but not rectal cancer surgery: A register-based study of 38,839 patients
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2025 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 156, no 9, p. 1703-1715Article in journal (Refereed) Published
Abstract [en]

Gut microbiota composition has been implicated in surgical site complications after colorectal cancer surgery. Antibiotics affect gut microbiota, but evidence for a role in surgical site complications is inconclusive. We aimed to investigate use of prescription antibiotics during the years before surgery in relation to the risk of surgical site infections, including anastomotic leakage, within 30 days after surgery. Cardiovascular/neurological complications and the urinary antiseptic methenamine hippurate, for which there is no clear link with the microbiota, were used as negative controls. We conducted a patient cohort study using complete population data from Swedish national registers between 2005 and 2020. The final study population comprised 26,527 colon cancer and 12,312 rectal cancer cases with a 4.5 year exposure window. In colon cancer patients, antibiotics use was associated with a higher risk of surgical site infections (adjusted odds ratio (aOR) for any versus no use = 1.20, 95% confidence interval (CI) 1.10–1.33) and anastomotic leakage in particular (aOR =1.19, 95% CI 1.03–1.36), both with dose–response relationships for increasing cumulative antibiotics use (Ptrend = <0.001 and Ptrend = 0.047, respectively). Conversely, associations in rectal cancer patients, as well as for the negative controls cardiovascular/neurological complications and methenamine hippurate, were null. In conclusion, prescription antibiotics use up to 4.5 years before colorectal cancer surgery is associated with a higher risk of surgical site infections, including anastomotic leakage, after colon cancer but not rectal cancer surgery. These findings support a role for antibiotics-induced intestinal dysbiosis in surgical site infections.

Place, publisher, year, edition, pages
John Wiley & Sons, 2025
Keywords
anastomotic leakage, antimicrobials, colorectal cancer surgery, gut microbiome, postoperative complications, surgical site infections
National Category
Surgery Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-232763 (URN)10.1002/ijc.35269 (DOI)001364450300001 ()39600222 (PubMedID)2-s2.0-85210363197 (Scopus ID)
Funder
Region Västerbotten, RV-932777Lions Cancerforskningsfond i Norr, LP 17-2154Knut and Alice Wallenberg Foundation
Available from: 2024-12-19 Created: 2024-12-19 Last updated: 2025-05-28Bibliographically approved
Hadrévi, J., Lu, S. S., Slunga-Järvholm, L., Palmqvist, R., Olsson, T., Harlid, S. & van Guelpen, B. (2025). Sick leave due to stress and subsequent cancer risk: a Swedish national registry study of 516,678 cancer cases. Cancer Medicine, 14(8), Article ID e70888.
Open this publication in new window or tab >>Sick leave due to stress and subsequent cancer risk: a Swedish national registry study of 516,678 cancer cases
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2025 (English)In: Cancer Medicine, E-ISSN 2045-7634, Vol. 14, no 8, article id e70888Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: This study examined whether sick leave due to severe stress (stress leave) and duration of leave are associated with future cancer risk.

METHODS: We conducted a matched case-control study using complete-population data from Swedish national registers (2005 to 2018), including 516,678 primary cancer cases and 2,357,433 matched controls. Odds ratios (OR) were calculated by conditional logistic regression and adjusted for pre-specified confounders.

RESULTS: Stress leave of any duration, reported to the Swedish Social Insurance Register, was associated with a slightly increased cancer risk, with the highest risk estimate for 1-30 versus 0 days (adjusted OR 1.05, 95% CI 1.02-1.09). In men, a clear exposure-response trend was present. We observed increased risks of prostate cancer (adjusted OR for > 90 days: 1.10, 95% CI 1.01-1.20) and cervical cancer (adjusted OR for > 90 days: 1.11, 95% CI 1.05-1.17, including cancer in situ). In etiology-based analyses, a positive association was found for smoking-related cancers, and the risk relationship for non-cervical HPV-related cancers was similar to that for cervical cancer. Risk estimates were above one for several types of stress in relation to overall cancer risk, including an exposure-response trend for acute stress reactions (p-trend 4.0 × 10-4) but a null association for post-traumatic stress disorder.

CONCLUSIONS: Stress leave was associated with a modestly higher risk of cancer overall and prostate and cervical cancers specifically. Regardless of whether the link is biological or reflective of lifestyle mediators or for cervical cancer, lower participation in screening, these findings suggest a potential relevance of severe stress for cancer prevention.

Place, publisher, year, edition, pages
John Wiley & Sons, 2025
Keywords
cancer, cervix cancer, exhaustion disorder, post‐traumatic stress disorder (PTSD), prostate cancer, sick leave, stress
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-238624 (URN)10.1002/cam4.70888 (DOI)001470141600001 ()40247782 (PubMedID)2-s2.0-105003706083 (Scopus ID)
Funder
Cancerforskningsfonden i NorrlandThe Kempe FoundationsRegion Västerbotten
Available from: 2025-05-12 Created: 2025-05-12 Last updated: 2025-05-12Bibliographically approved
Chalitsios, C. V., Markozannes, G., Papagiannopoulos, C., Aglago, E. K., Berndt, S. I., Buchanan, D. D., . . . Tsilidis, K. K. (2025). Waist circumference, a body shape index, and molecular subtypes of colorectal cancer: a pooled analysis of four cohort studies. Cancer Epidemiology, Biomarkers and Prevention, 34(4), 568-577
Open this publication in new window or tab >>Waist circumference, a body shape index, and molecular subtypes of colorectal cancer: a pooled analysis of four cohort studies
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2025 (English)In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 34, no 4, p. 568-577Article in journal (Refereed) Published
Abstract [en]

Background: Waist circumference (WC) and its allometric counterpart, “a body shape index” (ABSI), are risk factors for colorectal cancer; however, it is uncertain whether associations with these body measurements are limited to specific molecular subtypes of the disease.

Methods: Data from 2,772 colorectal cancer cases and 3,521 controls were pooled from four cohort studies within the Genetics and Epidemiology of Colorectal Cancer Consortium. Four molecular markers (BRAF mutation, KRAS mutation, CpG island methylator phenotype, and microsatellite instability) were analyzed individually and in combination (Jass types). Multivariable logistic and multinomial logistic models were used to assess the associations of WC and ABSI with overall colorectal cancer risk and, in case-only analyses, to evaluate heterogeneity by molecular subtype, respectively.

Results: Higher WC (ORper 5 cm ¼ 1.06, 95% confidence interval, 1.04–1.09) and ABSI (ORper 1-SD ¼ 1.07, 95% confidence interval, 1.00–1.14) were associated with elevated colorectal cancer risk. There was no evidence of heterogeneity between the molecular subtypes. No difference was observed regarding the influence of WC and ABSI on the four major molecular markers in proximal colon, distal colon, and rectal cancers, as well as in early- and late-onset colorectal cancers. Associations did not differ in the Jass-type analysis.

Conclusions: Higher WC and ABSI were associated with elevated colorectal cancer risk; however, they do not differentially influence all four major molecular mutations involved in colorectal carcinogenesis but underscore the importance of maintaining a healthy body weight in colorectal cancer prevention. Impact: The proposed results have potential utility in colorectal cancer prevention.

Place, publisher, year, edition, pages
American Association For Cancer Research (AACR), 2025
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-237785 (URN)10.1158/1055-9965.EPI-24-1534 (DOI)001459780500002 ()39898780 (PubMedID)2-s2.0-105002325823 (Scopus ID)
Funder
NIH (National Institutes of Health)
Available from: 2025-04-21 Created: 2025-04-21 Last updated: 2025-04-21Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0002-9692-101X

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