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Sandberg, Susanne
Publications (10 of 13) Show all publications
Manousou, S., Stål, M., Larsson, C., Mellberg, C., Lindahl, B., Eggertsen, R., . . . Nyström, H. F. (2018). A Paleolithic-type diet results in iodine deficiency: a 2-year randomized trial in postmenopausal obese women.. European Journal of Clinical Nutrition, 72(1), 124-129
Open this publication in new window or tab >>A Paleolithic-type diet results in iodine deficiency: a 2-year randomized trial in postmenopausal obese women.
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2018 (English)In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 72, no 1, p. 124-129Article in journal (Refereed) Published
Abstract [en]

BACKGROUND/OBJECTIVES: Different diets are used for weight loss. A Paleolithic-type diet (PD) has beneficial metabolic effects, but two of the largest iodine sources, table salt and dairy products, are excluded. The objectives of this study were to compare 24-h urinary iodine concentration (24-UIC) in subjects on PD with 24-UIC in subjects on a diet according to the Nordic Nutrition Recommendations (NNR) and to study if PD results in a higher risk of developing iodine deficiency (ID), than NNR diet.

SUBJECTS/METHODS: A 2-year prospective randomized trial in a tertiary referral center where healthy postmenopausal overweight or obese women were randomized to either PD (n=35) or NNR diet (n=35). Dietary iodine intake, 24-UIC, 24-h urinary iodine excretion (24-UIE), free thyroxin (FT4), free triiodothyronine (FT3) and thyrotropin (TSH) were measured at baseline, 6 and 24 months. Completeness of urine sampling was monitored by para-aminobenzoic acid and salt intake by urinary sodium.

RESULTS: At baseline, median 24-UIC (71.0 μg/l) and 24-UIE (134.0 μg/d) were similar in the PD and NNR groups. After 6 months, 24-UIC had decreased to 36.0 μg/l (P=0.001) and 24-UIE to 77.0 μg/d (P=0.001) in the PD group; in the NNR group, levels were unaltered. FT4, TSH and FT3 were similar in both groups, except for FT3 at 6 months being lower in PD than in NNR group.

CONCLUSIONS: A PD results in a higher risk of developing ID, than a diet according to the NNR. Therefore, we suggest iodine supplementation should be considered when on a PD.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-140504 (URN)10.1038/ejcn.2017.134 (DOI)000419795000017 ()28901333 (PubMedID)
Available from: 2017-10-12 Created: 2017-10-12 Last updated: 2019-05-21Bibliographically approved
Jin, C., Barone, A., Boren, T. & Sandberg, S. (2018). Helicobacter pylori-binding nonacid glycosphingolipids in the human stomach. Journal of Biological Chemistry, 293(44), 17248-17266
Open this publication in new window or tab >>Helicobacter pylori-binding nonacid glycosphingolipids in the human stomach
2018 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 293, no 44, p. 17248-17266Article in journal (Refereed) Published
Abstract [en]

Helicobacter pylori has a number of well-characterized carbohydrate-binding adhesins (BabA, SabA, and LabA) that promote adhesion to the gastric mucosa. In contrast, information on the glycoconjugates present in the human stomach remains unavailable. Here, we used MS and binding of carbohydrate-recognizing ligands to characterize the glycosphingolipids of three human stomachs from individuals with different blood group phenotypes (O(Rh-)P, A(Rh+)P, and A(Rh+)p), focusing on compounds recognized by H. pylori. We observed a high degree of structural complexity, and the composition of glycosphingolipids differed among individuals with different blood groups. The type 2 chain was the dominating core chain of the complex glycosphingolipids in the human stomach, in contrast to the complex glycosphingolipids in the human small intestine, which have mainly a type 1 core. H. pylori did not bind to the O(Rh-)P stomach glycosphingolipids, whose major complex glycosphingolipids were neolactotetraosylceramide, the Lex, Lea, and H type 2 pentaosylceramides, and the Ley hexaosylceramide. Several H. pylori-binding compounds were present among the A(Rh+)P and A(Rh+)p stomach glycosphingolipids. Ligands for BabA-mediated binding of H. pylori were the Leb hexaosylceramide, the H type 1 pentaosylceramide, and the A type 1/ALeb heptaosylceramide. Additional H. pylori-binding glycosphingolipids recognized by BabA-deficient strains were lactosylceramide, lactotetraosylceramide, the x2 pentaosylceramide, and neolactohexaosylceramide. Our characterization of human gastric receptors required for H. pylori adhesion provides a basis for the development of specific compounds that inhibit the binding of this bacterium to the human gastric mucosa.

Place, publisher, year, edition, pages
American Society for Biochemistry and Molecular Biology, 2018
Keywords
Helicobacter pylori, mass spectrometry (MS), glycolipid structure, adhesin, carbohydrate structure, ycoconjugate, virulence factor, gastric mucosa, glycosphingolipid characterization, H, pylori BabA hesin, Human gastric glycosphingolipids, microbial adhesion
National Category
Biochemistry and Molecular Biology Microbiology in the medical area
Identifiers
urn:nbn:se:umu:diva-153648 (URN)10.1074/jbc.RA118.004854 (DOI)000449466500024 ()30232154 (PubMedID)
Available from: 2018-11-27 Created: 2018-11-27 Last updated: 2018-11-27Bibliographically approved
Ahlgren, C., Hammarström, A., Sandberg, S., Lindahl, B., Olsson, T., Larsson, C. & Fjellman-Wiklund, A. (2016). Engagement in New Dietary Habits: Obese Women's Experiences from Participating in a 2-Year Diet Intervention. International Journal of Behavioral Medicine, 23(1), 84-93
Open this publication in new window or tab >>Engagement in New Dietary Habits: Obese Women's Experiences from Participating in a 2-Year Diet Intervention
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2016 (English)In: International Journal of Behavioral Medicine, ISSN 1070-5503, E-ISSN 1532-7558, Vol. 23, no 1, p. 84-93Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Dietary weight loss interventions most often result in weight loss, but weight maintenance on a long-term basis is the main problem in obesity treatment. There is a need for an increased understanding of the behaviour patterns involved in adopting a new dietary behavior and to maintain the behaviour over time.

PURPOSE: The purpose of this paper is to explore overweight and obese middle-aged women's experiences of the dietary change processes when participating in a 2-year-long diet intervention.

METHODS: Qualitative semi-structured interviews with 12 overweight and obese women (54-71 years) were made after their participation in a diet intervention programme. The programme was designed as a RCT study comparing a diet according to the Nordic nutrition recommendations (NNR diet) and a Palaeolithic diet (PD). Interviews were analysed according to Grounded Theory principles.

RESULTS: A core category "Engagement phases in the process of a diet intervention" concluded the analysis. Four categories included the informants' experiences during different stages of the process of dietary change: "Honeymoon phase", "Everyday life phase", "It's up to you phase" and "Crossroads phase". The early part of the intervention period was called "Honeymoon phase" and was characterised by positive experiences, including perceived weight loss and extensive support. The next phases, the "Everyday life phase" and "It's up to you phase", contained the largest obstacles to change. The home environment appeared as a crucial factor, which could be decisive for maintenance of the new dietary habits or relapse into old habits in the last phase called "Crossroads phase".

CONCLUSION: We identified various phases of engagement in the process of a long-term dietary intervention among middle-aged women. A clear personal goal and support from family and friends seem to be of major importance for long-term maintenance of new dietary habits. Gender relations within the household must be considered as a possible obstacle for women engaging in diet intervention.

Place, publisher, year, edition, pages
Springer, 2016
Keywords
Dietary habits, Engagement, Experience, Intervention, Obese, Qualitative study
National Category
Applied Psychology Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-111592 (URN)10.1007/s12529-015-9495-x (DOI)000370243400009 ()26041583 (PubMedID)
Available from: 2015-11-17 Created: 2015-11-17 Last updated: 2018-06-07Bibliographically approved
Chorell, E., Ryberg, M., Larsson, C., Sandberg, S., Mellberg, C., Lindahl, B., . . . Olsson, T. (2016). Plasma metabolomic response to postmenopausal weight loss induced by different diets. Metabolomics, 12(5), Article ID 85.
Open this publication in new window or tab >>Plasma metabolomic response to postmenopausal weight loss induced by different diets
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2016 (English)In: Metabolomics, ISSN 1573-3882, E-ISSN 1573-3890, Vol. 12, no 5, article id 85Article in journal (Refereed) Published
Abstract [en]

Background Menopause is associated with increased abdominal fat and increased risk of developing diabetes and cardiovascular disease. Objectives The present study evaluated the plasma metabolic response in relation to insulin sensitivity after weight loss via diet intervention. Methods This work includes two studies; i) Ten women on a 5 weeks Paleolithic-type diet (PD, 30 energy percent (E%) protein, 40 E% fat, 30 E% carbohydrates), ii) 55 women on 6 months of either PD or Nordic Nutrition Recommendations diet (NNR, 15 E% protein, 30 E% fat, and 55 E% carbohydrates). Plasma metabolic profiles were acquired at baseline and post diet using gas chromatography time-of-flight/mass spectrometry and investigated in relation to insulin sensitivity using multivariate bioinformatics. Results Both the PD and NNR diet resulted in significant weight loss, reduced waist circumference, improved serum lipid profiles, and improved insulin sensitivity. We detected a baseline metabolic profile that correlated significantly with insulin sensitivity, and of which components increased significantly in the PD group compared to NNR. Specifically, a significant increase in myo-inositol (MI), a second messenger of insulin action, and beta-hydroxybutyric acid (beta-HB)increased while dihomogamma-linoleic acid (DGLA) decreased in PD compared to NNR, which correlated with improved insulin sensitivity. We also detected a significant decrease in tyrosine and tryptophan, potential markers of insulin resistance when elevated in the circulation, with the PD but not the NNR. Conclusions Using metabolomics, we detected changes in the plasma metabolite profiles associated with weight loss in postmenopausal women by different diets. The metabolic profiles following 6 months of PD were linked to beneficial effects on insulin sensitivity compared to NNR.

Place, publisher, year, edition, pages
Springer, 2016
Keywords
Metabolomics, Mass spectrometry, Multivariate analysis, Paleolithic-type diet (PD), Nordic Nutrition commendation (NNR), Type 2 diabetes mellitus (T2DM), Insulin sensitivity, Weight loss, Myoinositol I), 1, 5-anhydroglucitol (1, 5-AG)
National Category
General Practice
Identifiers
urn:nbn:se:umu:diva-119058 (URN)10.1007/s11306-016-1013-x (DOI)000372157700008 ()
Available from: 2016-04-20 Created: 2016-04-11 Last updated: 2018-06-07Bibliographically approved
Otten, J., Mellberg, C., Ryberg, M., Sandberg, S., Kullberg, J., Lindahl, B., . . . Olsson, T. (2016). Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention. International Journal of Obesity, 40(5), 747-753
Open this publication in new window or tab >>Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention
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2016 (English)In: International Journal of Obesity, ISSN 0307-0565, E-ISSN 1476-5497, Vol. 40, no 5, p. 747-753Article in journal (Refereed) Published
Abstract [en]

BACKGROUND/OBJECTIVES: Our objective was to investigate changes in liver fat and insulin sensitivity during a 2-year diet intervention. An ad libitum Paleolithic diet (PD) was compared with a conventional low-fat diet (LFD).

SUBJECTS/METHODS: Seventy healthy, obese, postmenopausal women were randomized to either a PD or a conventional LFD. Diet intakes were ad libitum. Liver fat was measured with proton magnetic resonance spectroscopy. Insulin sensitivity was evaluated with oral glucose tolerance tests and calculated as homeostasis model assessment-insulin resistance (HOMA-IR)/liver insulin resistance (Liver IR) index for hepatic insulin sensitivity and oral glucose insulin sensitivity (OGIS)/Matsuda for peripheral insulin sensitivity. All measurements were performed at 0, 6 and 24 months. Forty-one women completed the examinations for liver fat and were included.

RESULTS: Liver fat decreased after 6 months by 64% (95% confidence interval: 54-74%) in the PD group and by 43% (27-59%) in the LFD group (P<0.01 for difference between groups). After 24 months, liver fat decreased 50% (25-75%) in the PD group and 49% (27-71%) in the LFD group. Weight reduction between baseline and 6 months was correlated to liver fat improvement in the LFD group (rs=0.66, P<0.01) but not in the PD group (rs=0.07, P=0.75). Hepatic insulin sensitivity improved during the first 6 months in the PD group (P<0.001 for Liver IR index and HOMA-IR), but deteriorated between 6 and 24 months without association with liver fat changes.

CONCLUSIONS: A PD with ad libitum intake had a significant and persistent effect on liver fat and differed significantly from a conventional LFD at 6 months. This difference may be due to food quality, for example, a higher content of mono- and polyunsaturated fatty acids in the PD. Changes in liver fat did not associate with alterations in insulin sensitivity.International Journal of Obesity advance online publication, 16 February 2016; doi:10.1038/ijo.2016.4.

National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-117538 (URN)10.1038/ijo.2016.4 (DOI)000377616500003 ()26786351 (PubMedID)
Funder
Swedish Research Council, K2011-12237-15-6
Available from: 2016-03-01 Created: 2016-03-01 Last updated: 2019-05-22Bibliographically approved
Mellberg, C., Sandberg, S., Ryberg, M., Eriksson, M., Brage, S., Larsson, C., . . . Lindahl, B. (2014). Long-term effects of a Palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial. European Journal of Clinical Nutrition, 68(3), 350-7
Open this publication in new window or tab >>Long-term effects of a Palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial
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2014 (English)In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 68, no 3, p. 350-7Article in journal (Refereed) Published
Abstract [en]

Background/Objectives: Short-term studies have suggested beneficial effects of a Palaeolithic-type diet (PD) on body weight and metabolic balance. We now report the long-term effects of a PD on anthropometric measurements and metabolic balance in obese postmenopausal women, in comparison with a diet according to the Nordic Nutrition Recommendations (NNR).

Subjects/Methods: Seventy obese postmenopausal women (mean age 60 years, body mass index 33 kg/m(2)) were assigned to an ad libitum PD or NNR diet in a 2-year randomized controlled trial. The primary outcome was change in fat mass as measured by dual-energy X-ray absorptiometry.

Results: Both groups significantly decreased total fat mass at 6 months (-6.5 and-2.6 kg) and 24 months (-4.6 and-2.9 kg), with a more pronounced fat loss in the PD group at 6 months (P<0.001) but not at 24 months (P=0.095). Waist circumference and sagittal diameter also decreased in both the groups, with a more pronounced decrease in the PD group at 6 months (-11.1 vs-5.8 cm, P=0.001 and-3.7 vs-2.0 cm, P<0.001, respectively). Triglyceride levels decreased significantly more at 6 and 24 months in the PD group than in the NNR group (P<0.001 and P=0.004). Nitrogen excretion did not differ between the groups.

Conclusions: A PD has greater beneficial effects vs an NNR diet regarding fat mass, abdominal obesity and triglyceride levels in obese postmenopausal women; effects not sustained for anthropometric measurements at 24 months. Adherence to protein intake was poor in the PD group. The long-term consequences of these changes remain to be studied.

Place, publisher, year, edition, pages
Nature Publishing Group, 2014
Keywords
adipose tissue, diet, insulin resistance, postmenopausal, weight
National Category
Nutrition and Dietetics Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-86275 (URN)10.1038/ejcn.2013.290 (DOI)000332634300011 ()24473459 (PubMedID)
Note

C. Mellberg, S. Sandberg and M. Ryberg share first authorship.

T. Olsson and B. Lindahl share senior authorship.

Available from: 2014-02-21 Created: 2014-02-21 Last updated: 2018-06-08Bibliographically approved
Ryberg, M., Sandberg, S., Mellberg, C., Stegle, O., Lindahl, B., Larsson, C., . . . Olsson, T. (2013). A Palaeolithic-type diet causes strong tissue-specific effects on ectopic fat deposition in obese postmenopausal women. Journal of Internal Medicine, 274(1), 67-76
Open this publication in new window or tab >>A Palaeolithic-type diet causes strong tissue-specific effects on ectopic fat deposition in obese postmenopausal women
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2013 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 274, no 1, p. 67-76Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Ectopic fat accumulation in liver and skeletal muscle may be an essential link between abdominal obesity, insulin resistance and increased risk of cardiovascular disease after menopause. We hypothesized that a diet containing a relatively high content of protein and unsaturated fat [mainly monounsaturated fatty acids (MUFAs)] but limited carbohydrates and saturated fat would reduce lipid content in liver and muscle and increase insulin sensitivity in postmenopausal women.

SUBJECTS: Ten healthy, nonsmoking postmenopausal women with a body mass index (BMI) >27 (28-35) kg m-2 were included in the study.

INTERVENTIONS: Participants were instructed to consume an ad libitum Palaeolithic-type diet intended to provide approximately 30 energy percentage (E%) protein, 40 E% fat (mainly MUFAs) and 30 E% carbohydrate. Intramyocellular lipid (IMCL) levels in calf muscles and liver triglyceride levels were quantified using proton magnetic resonance spectroscopy (1 H-MRS) before and 5 weeks after dietary intervention. Insulin sensitivity was estimated by homoeostasis model assessment (HOMA) indices and the euglycaemic hyperinsulinaemic clamp technique.

RESULTS: Mean energy intake decreased by 25% with a weight loss of 4.5 kg. BMI, waist and hip circumference, waist/hip ratio and abdominal sagittal diameter also decreased significantly, as did diastolic blood pressure (mean -7 mmHg), levels of fasting serum glucose, cholesterol, triglycerides, LDL/HDL cholesterol, apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1), urinary C-peptide and HOMA indices. Whole-body insulin sensitivity did not change. Liver triglyceride levels decreased by 49%, whereas IMCL levels in skeletal muscle were not significantly altered.

CONCLUSIONS: A modified Palaeolithic-type diet has strong and tissue-specific effects on ectopic lipid deposition in postmenopausal women.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2013
Keywords
adipose tissue, diet, fatty liver, insulin resistance, postmenopausal, weight
National Category
Occupational Health and Environmental Health Nutrition and Dietetics
Research subject
Food and Nutrition
Identifiers
urn:nbn:se:umu:diva-67135 (URN)10.1111/joim.12048 (DOI)000320279000005 ()23414424 (PubMedID)
Available from: 2013-03-14 Created: 2013-03-14 Last updated: 2018-06-08Bibliographically approved
Ryberg, M., Sandberg, S., Mellberg, C., Stegle, O., Lindahl, B., Larsson, C., . . . Olsson, T. (2013). Tissue-specific effects on ectopic lipid deposition by a Palaeolithic-type diet in obese postmenopausal women. Journal of Internal Medicine, 274(1), 67-76
Open this publication in new window or tab >>Tissue-specific effects on ectopic lipid deposition by a Palaeolithic-type diet in obese postmenopausal women
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2013 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 274, no 1, p. 67-76Article in journal (Refereed) Published
Abstract [en]

Objectives Ectopic fat accumulation in liver and skeletal muscle may be an essential link between abdominal obesity, insulin resistance and increased risk of cardiovascular disease after menopause. We hypothesized that a diet containing a relatively high content of protein and unsaturated fat [mainly monounsaturated fatty acids (MUFAs)] but limited carbohydrates and saturated fat would reduce lipid content in liver and muscle and increase insulin sensitivity in postmenopausal women.

Subjects Ten healthy, nonsmoking postmenopausal women with a body mass index (BMI) >27 (28–35) kg m−2 were included in the study.

Interventions Participants were instructed to consume an ad libitum Palaeolithic-type diet intended to provide approximately 30 energy percentage (E%) protein, 40 E% fat (mainly MUFAs) and 30 E% carbohydrate. Intramyocellular lipid (IMCL) levels in calf muscles and liver triglyceride levels were quantified using proton magnetic resonance spectroscopy (1H-MRS) before and 5 weeks after dietary intervention. Insulin sensitivity was estimated by homoeostasis model assessment (HOMA) indices and the euglycaemic hyperinsulinaemic clamp technique.

Results Mean energy intake decreased by 25% with a weight loss of 4.5 kg. BMI, waist and hip circumference, waist/hip ratio and abdominal sagittal diameter also decreased significantly, as did diastolic blood pressure (mean −7 mmHg), levels of fasting serum glucose, cholesterol, triglycerides, LDL/HDL cholesterol, apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1), urinary C-peptide and HOMA indices. Whole-body insulin sensitivity did not change. Liver triglyceride levels decreased by 49%, whereas IMCL levels in skeletal muscle were not significantly altered.

Conclusions A modified Palaeolithic-type diet has strong and tissue-specific effects on ectopic lipid deposition in postmenopausal women.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2013
Keywords
adipose tissue, diet, fatty liver, insulin resistance, postmenopausal, weight
National Category
Occupational Health and Environmental Health General Practice
Identifiers
urn:nbn:se:umu:diva-62255 (URN)10.1111/joim.12048 (DOI)000320279000005 ()
Available from: 2012-12-13 Created: 2012-12-13 Last updated: 2018-06-08Bibliographically approved
Otten, J., Mellberg, C., Hauksson, J., Sandberg, S., Larsson, C., Lindahl, B., . . . Olsson, T. (2012). Diet influence on peripheral and hepatic insulin sensitivity.. In: : . Paper presented at Keystone symposium "Genetic and Molecular Basis of Obesity and Body Weight Regulation", Santa Fe, New Mexico, 29 Jan-3 Feb.
Open this publication in new window or tab >>Diet influence on peripheral and hepatic insulin sensitivity.
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2012 (English)Conference paper, Published paper (Refereed)
National Category
Clinical Medicine
Identifiers
urn:nbn:se:umu:diva-60623 (URN)
Conference
Keystone symposium "Genetic and Molecular Basis of Obesity and Body Weight Regulation", Santa Fe, New Mexico, 29 Jan-3 Feb
Available from: 2012-10-19 Created: 2012-10-19 Last updated: 2019-08-07Bibliographically approved
Sandberg, S., Mellberg, C., Ryberg, M., Olsson, T., Larsson, C. & Lindahl, B. (2012). Does a paleolithic-type diet have a better effect than a conventional low-fat diet in achieving long-term weight loss among obese post-menopausal women?. In: : . Paper presented at 12th International Congress of Behavioural Medicine, Budapest, Hungary, 29 August - 1 September 2012.
Open this publication in new window or tab >>Does a paleolithic-type diet have a better effect than a conventional low-fat diet in achieving long-term weight loss among obese post-menopausal women?
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2012 (English)Conference paper, Oral presentation only (Refereed)
National Category
Clinical Medicine Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-60629 (URN)
Conference
12th International Congress of Behavioural Medicine, Budapest, Hungary, 29 August - 1 September 2012
Available from: 2012-10-19 Created: 2012-10-19 Last updated: 2018-06-08Bibliographically approved
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