umu.sePublications
Change search
Link to record
Permanent link

Direct link
BETA
Lindh, Jack
Publications (10 of 35) Show all publications
Brandefors, L., Lindh, J., Preuss, K.-D., Fadle, N., Pfreundschuh, M. & Kimby, E. (2019). Incidence and inheritance of hyperphosphorylated paratarg-7 in patients with Waldenstrom's macroglobulinaemia in Sweden [Letter to the editor]. Acta Oncologica, 58(6), 824-827
Open this publication in new window or tab >>Incidence and inheritance of hyperphosphorylated paratarg-7 in patients with Waldenstrom's macroglobulinaemia in Sweden
Show others...
2019 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 58, no 6, p. 824-827Article in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
Taylor & Francis Group, 2019
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-158750 (URN)10.1080/0284186X.2019.1582798 (DOI)000463291800001 ()30888245 (PubMedID)
Available from: 2019-05-15 Created: 2019-05-15 Last updated: 2019-08-27Bibliographically approved
Ångström-Brännström, C., Lindh, V., Nyholm, T., Lindh, J. & Engvall, G. (2019). Staff's Experiences of Preparing and Caring for Children With Cancer and Their Families During the Child's Radiotherapy. Cancer Nursing, 42(5), E10-E18
Open this publication in new window or tab >>Staff's Experiences of Preparing and Caring for Children With Cancer and Their Families During the Child's Radiotherapy
Show others...
2019 (English)In: Cancer Nursing, ISSN 0162-220X, E-ISSN 1538-9804, Vol. 42, no 5, p. E10-E18Article in journal (Refereed) Published
Abstract [en]

Background: Approximately one-third of children diagnosed with cancer are treated with radiotherapy (RT). Staff experiences of preparing and distracting the children and their families during a child’s RT are sparsely described.

Objective: The aim of this study was to describe staff experiences of preparing and caring for children with cancer and their families during the child’s RT.

Intervention/Methods: Semistructured interviews with staff were performed at 3 Swedish RT centers. The interviews were analyzed using inductive qualitative content analysis.

Results: The analysis revealed 5 categories summarizing the staff members’ experiences. These include the following: experiences of various emotions; care for the child and the child’s family; commitments before, during, and after RT; organizational issues; and experiences of the intervention and suggestions for improvement.

Conclusions: The preparatory intervention facilitated the ability of staff members to conduct their work, although the intervention should be specifically tailored to each child. Meeting children and their families and providing care to both during RT were challenging. The staff strived to provide optimal care for each child and family. Interdisciplinary teamwork and organizational acceptance for the importance of preparation and distraction were essential.

Implications for Practice: A future challenge will be to provide opportunities for all staff involved in the treatment of children with cancer to develop their skills continuously in order to provide high-quality preparation and distraction to all children undergoing RT, regardless of the geographical location of the RT center.

Place, publisher, year, edition, pages
Wolters Kluwer, 2019
Keywords
Children, Distraction, Experiences, Families, Interviews, Preparation, Qualitative content analysis, Radiotherapy, Staff
National Category
Nursing
Identifiers
urn:nbn:se:umu:diva-151279 (URN)10.1097/NCC.0000000000000635 (DOI)000485022700002 ()30085946 (PubMedID)2-s2.0-85071541953 (Scopus ID)
Funder
Swedish Childhood Cancer Foundation
Available from: 2018-08-31 Created: 2018-08-31 Last updated: 2019-11-14Bibliographically approved
Engvall, G., Lindh, V., Mullaney, T., Nyholm, T., Lindh, J. & Ångström-Brännström, C. (2018). Children's experiences and responses towards an intervention for psychological preparation for radiotherapy. Radiation Oncology, 13, Article ID 9.
Open this publication in new window or tab >>Children's experiences and responses towards an intervention for psychological preparation for radiotherapy
Show others...
2018 (English)In: Radiation Oncology, ISSN 1748-717X, E-ISSN 1748-717X, Vol. 13, article id 9Article in journal (Refereed) Published
Abstract [en]

Background: Children can experience distress when undergoing radiotherapy as a reaction to being scared of and unfamiliar with the procedure. The aim was to evaluate children's experiences and responses towards an intervention for psychological preparation for radiotherapy.

Methods: A case control design with qualitative content analysis of semi-structured interviews and statistical analysis of anxiety ratings were used for evaluating a strategy for psychological preparation and distraction. Fifty-seven children aged 2 to 18 years and their parents participated - 30 children in the baseline group and 27 in the intervention group. Child interviews were performed and the child and their parents rated the child's anxiety.

Results: The intervention was most appropriate for the younger children, who enjoyed the digital story, the stuffed animal and training with their parents. There were some technical problems and the digital story was not detailed enough to fit exactly with various cancer diagnoses. Children described suggestions for improvement of the intervention. The ratings of the child's anxiety during radiation treatment showed no differences between the baseline group and the intervention group.

Conclusions: The children of all the age groups experienced their interventions as positive. The strength of the intervention was that it encouraged interaction within the family and provided an opportunity for siblings and peers to take part in what the child was going through. Future research on children's experiences to interventions should be encouraged. The intervention and the technical solutions could improve by further development.

Trial registration: The study design was structured as an un-matched case-control study, baseline group vs. intervention group. Trial registration: ClinicalTrials.gov NCT02993978 , Protocol Record 2012-113-31 M. Retrospectively registered - 21 November 2016.

Place, publisher, year, edition, pages
BioMed Central, 2018
Keywords
childhood cancer, children’s experiences, distraction, psychological preparation, radiotherapy
National Category
Nursing
Identifiers
urn:nbn:se:umu:diva-144573 (URN)10.1186/s13014-017-0942-5 (DOI)000423350200001 ()29357940 (PubMedID)
Available from: 2018-02-06 Created: 2018-02-06 Last updated: 2018-06-09Bibliographically approved
Brandefors, L., Melin, B. S., Lindh, J., Lundqvist, K. & Kimby, E. (2018). Prognostic factors and primary treatment for Waldenstrom macroglobulinemia: a Swedish Lymphoma Registry study. British Journal of Haematology, 183(4), 564-577
Open this publication in new window or tab >>Prognostic factors and primary treatment for Waldenstrom macroglobulinemia: a Swedish Lymphoma Registry study
Show others...
2018 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 183, no 4, p. 564-577Article in journal (Refereed) Published
Abstract [en]

We present a nationwide prospective Swedish registry-based study of Waldenstrom macroglobulinaemia (WM), that focuses on incidence and survival in relation to clinical prognostic factors and primary systemic therapies. A total of 1511 patients with WM and lymphoplasmocytic lymphoma (LPL) were registered in the Swedish Lymphoma Registry (SLR) between 1 January 2000 and 31 December 2014. The age-adjusted incidence of WM/LPL was 11.5 per million persons per year, three times higher than the reported incidence worldwide. Medical records were retrieved for 1135 patients (75%). A retrospective review showed that 981 (86.1%) of these patients fulfilled the World Health Organization diagnostic criteria for WM and these patients were analysed further. The overall survival (OS) improved between two periods - 2000-2006 and 2007-2014 - with a five-year OS of 61% and 70%, respectively. Significant prognostic factors for OS, evaluated at the time of diagnosis, were age, elevated lactate dehydrogenase level and haemoglobin <= 115 g/l for patients receiving therapy 0-3 months after diagnosis, and age, poor performance status, haemoglobin <= 115 g/l, and female sex in "watch and wait" patients (multivariable analysis). The level of the IgM monoclonal immunoglobulin had no significant prognostic value. Rituximab included in first-line therapy was associated with improved survival.

Place, publisher, year, edition, pages
WILEY, 2018
Keywords
Waldenstrom macroglobulinaemia, lymphoproliferative disease, prognostic factors, therapy, ldenstrom macroglobulinaemia survival
National Category
Hematology
Identifiers
urn:nbn:se:umu:diva-154355 (URN)10.1111/bjh.15558 (DOI)000451480400006 ()30198549 (PubMedID)
Available from: 2018-12-17 Created: 2018-12-17 Last updated: 2018-12-17Bibliographically approved
Pixberg, C., Koch, R., Eich, H. T., Martinsson, U., Kristensen, I., Matuschek, C., . . . Steinmann, D. (2016). Acute Toxicity Grade 3 and 4 After Irradiation in Children and Adolescents: Results From the IPPARCA Collaboration. International Journal of Radiation Oncology, Biology, Physics, 94(4), 792-799
Open this publication in new window or tab >>Acute Toxicity Grade 3 and 4 After Irradiation in Children and Adolescents: Results From the IPPARCA Collaboration
Show others...
2016 (English)In: International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, E-ISSN 1879-355X, Vol. 94, no 4, p. 792-799Article in journal (Refereed) Published
Abstract [en]

Purpose: In the context of oncologic therapy for children, radiation therapy is frequently indicated. This study identified the frequency of and reasons for the development of high-grade acute toxicity and possible sequelae.

Materials and Methods: Irradiated children have been prospectively documented since 2001 in the Registry for the Evaluation of Side Effects After Radiation in Childhood and Adolescence (RiSK) database in Germany and since 2008 in the registry for radiation therapy toxicity (RADTOX) in Sweden. Data were collected using standardized, published forms. Toxicity classification was based on Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria.

Results: As of June 2013, 1500 children have been recruited into the RiSK database and 485 into the RADTOX registry leading to an analysis population of 1359 patients (age range 0-18). A total of 18.9% (n=257) of all investigated patients developed high-grade acute toxicity (grades 3/4). High-grade toxicity of the bone marrow was documented for 63.8% (n=201) of those patients, oral mucositis for 7.6% (n=24), and dermatitis for 7.6% (n=24). Patients with high-grade acute toxicity received concomitant chemotherapy more frequently (56%) than patients with no or lower acute toxicity (31.5%). In multivariate analyses, concomitant chemotherapy, diagnosis of Ewing sarcoma, and total radiation dose showed a statistically noticeable effect (P <=.05) on acute toxicity, whereas age, concomitant chemotherapy, Hodgkin lymphoma, Ewing sarcoma, total radiation dose, and acute toxicity influenced the time until maximal late toxicity.

Conclusions: Generally, high-grade acute toxicity after irradiation in children and adolescence occurs in a moderate proportion of patients (18.9%). As anticipated, the probability of acute toxicity appeared to depend on the prescribed dose as well as concomitant chemotherapy. The occurrence of chronic toxicity correlates with the prior acute toxicity grade. Age seems to influence the time until maximal late toxicity but not the development of acute toxicity.

National Category
Cancer and Oncology Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:umu:diva-118962 (URN)10.1016/j.ijrobp.2015.12.353 (DOI)000371581900020 ()
Available from: 2016-04-19 Created: 2016-04-07 Last updated: 2018-06-07Bibliographically approved
Lindh, V., Engvall, G., Ångström-Brännström, C., Nilsson, K., Wickart-Johansson, G. & Lindh, J. (2016). Children's voices on experiencing radiotherapy. Paper presented at Oncology Nursing Society (ONS) 41st Annual Congress, April 28-May 1, 2016, San Antonio, TX. Oncology Nursing Forum, 43(2), 134-134
Open this publication in new window or tab >>Children's voices on experiencing radiotherapy
Show others...
2016 (English)In: Oncology Nursing Forum, ISSN 0190-535X, E-ISSN 1538-0688, Vol. 43, no 2, p. 134-134Article in journal, Meeting abstract (Other academic) Published
National Category
Cancer and Oncology Nursing
Identifiers
urn:nbn:se:umu:diva-120662 (URN)000373613900380 ()
Conference
Oncology Nursing Society (ONS) 41st Annual Congress, April 28-May 1, 2016, San Antonio, TX
Note

Meeting Abstract: 201

Available from: 2016-12-14 Created: 2016-05-18 Last updated: 2018-06-09Bibliographically approved
Ångstrom-Brännström, C., Engvall, G., Mullaney, T., Nilsson, K., Wickart-Johansson, G., Svärd, A. M., . . . Lindh, V. (2016). Facilitating Radiotherapy for Children: Technique, Design and Professional Care in Synergy, a Multicenter Intervention Study. Paper presented at 48th Congress of the International Society of Paediatric Oncology (SIOP) Dublin, Ireland October 19–22, 2016. Pediatric Blood & Cancer, 63, S213-S213
Open this publication in new window or tab >>Facilitating Radiotherapy for Children: Technique, Design and Professional Care in Synergy, a Multicenter Intervention Study
Show others...
2016 (English)In: Pediatric Blood & Cancer, ISSN 1545-5009, E-ISSN 1545-5017, Vol. 63, p. S213-S213Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Wiley-Blackwell, 2016
National Category
Cancer and Oncology Pediatrics
Identifiers
urn:nbn:se:umu:diva-129743 (URN)000384818801290 ()
Conference
48th Congress of the International Society of Paediatric Oncology (SIOP) Dublin, Ireland October 19–22, 2016
Note

Supplement: 3

Meeting Abstract: P-0582

Available from: 2017-01-10 Created: 2017-01-09 Last updated: 2018-06-09Bibliographically approved
Brandefors, L., Kimby, E., Lundqvist, K., Melin, B. & Lindh, J. (2016). Familial Waldenstrom's macroglobulinemia and relation to immune defects, autoimmune diseases, and haematological malignancies: a population-based study from northern Sweden. Acta Oncologica, 55(1), 91-98
Open this publication in new window or tab >>Familial Waldenstrom's macroglobulinemia and relation to immune defects, autoimmune diseases, and haematological malignancies: a population-based study from northern Sweden
Show others...
2016 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 55, no 1, p. 91-98Article in journal (Refereed) Published
Abstract [en]

Background: Waldenstrom's macroglobulinemia (WM) is a rare lymphoprolipherative disorder with geographic and ethnic disparities in incidence. The cause of WM remains mostly unknown although a role for genetic, immune-related, and environmental factors has been suggested. Most cases of WM are sporadic although familial cases occur. Aim: This study estimated the incidence of WM in northern Sweden and identified and described patients with familial WM in this area. Patients and methods: The Swedish and Northern Lymphoma Registry, the Swedish Cancer Registry (1997-2011), and medical records were used to identify patients with WM in two counties (Norrbotten and Västerbotten) in northern Sweden and to calculate the overall age-adjusted incidence (2000-2012). We identified 12 families with a family history of WM, IgM monoclonal gammophathy (MGUS), and/or multiple myeloma (MM). Results: In Norrbotten and Västerbotten, the age-adjusted incidence of WM/LPL is 1.75 and 1.48 per 100 000 persons per year, respectively (2000-2012), rates that are higher than the overall incidence of WM/LPL in Sweden (1.05 per 100 000 persons per year; 2000-2012). Autoimmune diseases and other haematological malignancies in the medical history (their own or in relatives) were reported in 9/12 and 5/12 families, respectively. A high proportion of abnormal serum protein electrophoresis was found in the relatives; 12/56 (21%) had a MGUS and 13/56 (25%) showed abnormalities in the immunoglobulin levels (i.e. subnormal levels and poly/oligoclonality). Conclusion: The incidence of WM in Norrbotten and Västerbotten counties was higher than expected. We found a strong correlation between autoimmune/inflammatory diseases, other haematological malignancies, and familial WM and a high frequency of serum immunoglobulin abnormalities in the relatives of the WM patients, findings that strengthen the hypothesis that the aetiology of WM depends on both immune-related and genetic factors.

Place, publisher, year, edition, pages
Taylor & Francis, 2016
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-114606 (URN)10.3109/0284186X.2015.1096019 (DOI)000367007700013 ()26559865 (PubMedID)
Note

Published online: 11 Nov 2015

Available from: 2016-02-11 Created: 2016-01-25 Last updated: 2018-06-07Bibliographically approved
Engvall, G., Ångström-Brännström, C., Mullaney, T., Nilsson, K., Wickart-Johansson, G., Svärd, A.-M., . . . Lindh, V. (2016). It Is Tough and Tiring but It Works - Children's Experiences of Undergoing Radiotherapy. PLoS ONE, 11(4), Article ID e0153029.
Open this publication in new window or tab >>It Is Tough and Tiring but It Works - Children's Experiences of Undergoing Radiotherapy
Show others...
2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 4, article id e0153029Article in journal (Refereed) Published
Abstract [en]

Approximately 300 children ages 0 to 18 are diagnosed with cancer in Sweden every year, and 80 to 90 of them undergo radiotherapy treatment. The aim was to describe children's experiences of preparing for and undergoing radiotherapy, and furthermore to describe children's suggestions for improvement. Thirteen children between the ages of 5 and 15 with various cancer diagnoses were interviewed. Data was analyzed using qualitative content analysis. The findings revealed five categories: positive and negative experiences with hospital stays and practical arrangements; age-appropriate information, communication, and guidance to various degrees; struggle with emotions; use of distraction and other suitable coping strategies; and children's suggestions for improvement during radiotherapy. An overarching theme emerged: "It is tough and tiring but it works". Some key areas were: explanatory visits, the need for information and communication, being afraid, discomfort and suffering, the need for media distraction, dealing with emotions, and the need for support. A systematic, family-centered preparation program could possible help families prepare and individualized distraction during radiotherapy could contribute to reducing distress. Further studies with interventions could clarify successful programs.

Keywords
Children, cancer, radiotherapy, interviews, experiences
National Category
Nursing Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:umu:diva-119076 (URN)10.1371/journal.pone.0153029 (DOI)000373608000066 ()27055258 (PubMedID)
Available from: 2016-04-11 Created: 2016-04-11 Last updated: 2018-06-07Bibliographically approved
Norberg, M., Magnusson, E., Thyme, K. E., Åström, S., Lindh, J. & Öster, I. (2015). Breast Cancer Survivorship: Intersecting Gendered Discourses in a 5-Year Follow-Up Study. Health Care for Women International, 36(5), 617-633
Open this publication in new window or tab >>Breast Cancer Survivorship: Intersecting Gendered Discourses in a 5-Year Follow-Up Study
Show others...
2015 (English)In: Health Care for Women International, ISSN 0739-9332, E-ISSN 1096-4665, Vol. 36, no 5, p. 617-633Article in journal (Refereed) Published
Abstract [en]

In this article we present a follow-up study of women's interview narratives about life five to seven years after a breast cancer operation. The women had taken part in a study during the six-month post-operation period. Art therapy contributed to well-being, including strengthening personal boundaries. In the new study, interview analysis informed by critical discursive psychology indicated three problematic discourses that the women still struggled with several years after the operation: the female survivor, the "good woman", individual responsibility. We concluded that many women with a history of breast cancer need support several years after their medical treatment is finished.

Keywords
breast cancer, art therapy, gender, follow-up, critical disursive psycology
National Category
Nursing
Identifiers
urn:nbn:se:umu:diva-101160 (URN)10.1080/07399332.2015.1017640 (DOI)000353712900004 ()25692802 (PubMedID)
External cooperation:
Available from: 2015-03-26 Created: 2015-03-23 Last updated: 2018-06-07Bibliographically approved
Organisations

Search in DiVA

Show all publications