Open this publication in new window or tab >>International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Institute of Health Research, University of Health and Allied Sciences, Ho, Ghana.
Kintampo Health Research Centre, Kintampo, Ghana.
Manhiça Health Research Centre, Manhiça, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
MRC–Wits Rural Public Health and Health Transitions Research Unit (Agincourt), University of the Witwatersrand, Johannesburg, South Africa.
School of Applied Human Sciences, University of Kwazulu-Natal, Durban, South Africa.
Department of Family Medicine, Hanoi Medical University, Hanoi, Viet Nam.
Institute for Population and Social Research, Mahidol University, Nakhonpathom, Thailand.
Manhiça Health Research Centre, Manhiça, Mozambique; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Department of Family Medicine, Hanoi Medical University, Hanoi, Viet Nam.
Institute of Mathematics, Vietnam Academy of Science and Technology, Hanoi, Viet Nam.
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Manhiça Health Research Centre, Manhiça, Mozambique.
Kintampo Health Research Centre, Kintampo, Ghana.
Kintampo Health Research Centre, Kintampo, Ghana.
Kintampo Health Research Centre, Kintampo, Ghana.
Dodowa Health Research Centre, Dodowa, Ghana.
Dodowa Health Research Centre, Dodowa, Ghana.
Dodowa Health Research Centre, Dodowa, Ghana.
Dodowa Health Research Centre, Dodowa, Ghana.
MRC–Wits Rural Public Health and Health Transitions Research Unit (Agincourt), University of the Witwatersrand, Johannesburg, South Africa.
Nuffied Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Manhiça Health Research Centre, Manhiça, Mozambique.
MRC–Wits Rural Public Health and Health Transitions Research Unit (Agincourt), University of the Witwatersrand, Johannesburg, South Africa.
Oxford University Clinical Research Unit, Hanoi, Viet Nam; Nuffied Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
School of Public Health, University of the Witwatersrand, Johannesburg, South Africa; Statistics Sierra Leone, Freetown, Sierra Leone; University Secretariat, Njala University, Njala, Sierra Leone; Heidelberg Institute for Global Health, University of Heidelberg Medical School, Heidelberg, Germany.
Umeå University, Faculty of Medicine, Department of Epidemiology and Global Health.
Oxford University Clinical Research Unit, Hanoi, Viet Nam.
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2021 (English)In: The Lancet Global Health, E-ISSN 2214-109X, Vol. 9, no 5, p. e610-e619Article in journal (Refereed) Published
Abstract [en]
Background: Antimicrobial misuse is common in low-income and middle-income countries (LMICs), and this practice is a driver of antibiotic resistance. We compared community-based antibiotic access and use practices across communities in LMICs to identify contextually specific targets for interventions to improve antibiotic use practices.
Methods: We did quantitative and qualitative assessments of antibiotic access and use in six LMICs across Africa (Mozambique, Ghana, and South Africa) and Asia (Bangladesh, Vietnam, and Thailand) over a 2·5-year study period (July 1, 2016–Dec 31, 2018). We did quantitative assessments of community antibiotic access and use through supplier mapping, customer exit interviews, and household surveys. These quantitative assessments were triangulated with qualitative drug supplier and consumer interviews and discussions.
Findings: Vietnam and Bangladesh had the largest proportions of non-licensed antibiotic dispensing points. For mild illness, drug stores were the most common point of contact when seeking antibiotics in most countries, except South Africa and Mozambique, where public facilities were most common. Self-medication with antibiotics was found to be widespread in Vietnam (55·2% of antibiotics dispensed without prescription), Bangladesh (45·7%), and Ghana (36·1%), but less so in Mozambique (8·0%), South Africa (1·2%), and Thailand (3·9%). Self-medication was considered to be less time consuming, cheaper, and overall, more convenient than accessing them through health-care facilities. Factors determining where treatment was sought often involved relevant policies, trust in the supplier and the drug, disease severity, and whether the antibiotic was intended for a child. Confusion regarding how to identify oral antibiotics was revealed in both Africa and Asia.
Interpretation: Contextual complexities and differences between countries with different incomes, policy frameworks, and cultural norms were revealed. These contextual differences render a single strategy inadequate and instead necessitate context-tailored, integrated intervention packages to improve antibiotic use in LMICs as part of global efforts to combat antibiotic resistance.
Place, publisher, year, edition, pages
Elsevier, 2021
National Category
Public Health, Global Health, Social Medicine and Epidemiology Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:umu:diva-182479 (URN)10.1016/S2214-109X(21)00024-3 (DOI)000642463300026 ()2-s2.0-85104108687 (Scopus ID)
Funder
Wellcome trust
2021-04-292021-04-292023-09-05Bibliographically approved