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Chmielewska, Anna
Publications (5 of 5) Show all publications
Berglund, S. K., Chmielewska, A., Starnberg, J., Westrup, B., Hägglöf, B., Norman, M. & Domellöf, M. (2018). Effects of iron supplementation of low-birth-weight infants on cognition and behavior at 7 years: a randomized controlled trial. Pediatric Research, 83, 111-118
Open this publication in new window or tab >>Effects of iron supplementation of low-birth-weight infants on cognition and behavior at 7 years: a randomized controlled trial
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2018 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 83, p. 111-118Article in journal (Refereed) Published
Abstract [en]

Background Low-birth-weight infants (LBW) are at an increased risk of iron deficiency that has been associated with impaired neurodevelopment. We hypothesized that iron supplementation of LBW infants improves cognitive scores and reduces behavioral problems until school age.

Methods We randomized 285 marginally LBW (2,000-2,500 g) infants to receive 0, 1, or 2 mg/kg/day of iron supplements from 6 weeks to 6 months of age. At 7 years of age, 205 participants were assessed regarding cognition using Wechsler Intelligence Scale for Children (WISC-IV) and behavior using the parental questionnaires Child Behavior Checklist (CBCL) and Five to Fifteen (FTF).

Results There were no significant differences between the intervention groups in WISC-IV or FTF. However, the CBCL scores for externalizing problems were significantly different, in favor of supplemented children (P=0.045). When combining the supplemented groups, they had significantly lower scores for externalizing behavior compared with placebo (median (interquartile range): 44 [34;51] vs. 48.5 [41;56] P=0.013), and their risk ratio (95% confidence interval) for a total behavioral score above the cutoff for clinical problems was 0.31 (0.09-1.0), P=0.054.

Conclusion Lower scores of externalizing behavior in supplemented children support our previous findings at 3 years, and suggest that iron supplementation may have long-lasting effects on behavioral functions.

Place, publisher, year, edition, pages
New York: Nature Publishing Group, 2018
Keywords
weeks gestational age, children born, late preterm, deficiency anemia, brain, growth, childhood, disorder, outcomes, risk
National Category
Pediatrics
Identifiers
urn:nbn:se:umu:diva-145099 (URN)10.1038/pr.2017.235 (DOI)000426175900019 ()28953856 (PubMedID)
Available from: 2018-02-21 Created: 2018-02-21 Last updated: 2018-11-13Bibliographically approved
Manousou, S., Johansson, B., Chmielewska, A., Eriksson, J., Gutefeldt, K., Tornhage, C.-J., . . . Nyström Filipsson, H. (2018). Role of iodine-containing multivitamins during pregnancy for children’s brain function: protocol of an ongoing randomised controlled trial: the SWIDDICH study. BMJ Open, 8(4), Article ID e019945.
Open this publication in new window or tab >>Role of iodine-containing multivitamins during pregnancy for children’s brain function: protocol of an ongoing randomised controlled trial: the SWIDDICH study
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2018 (English)In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 8, no 4, article id e019945Article in journal (Refereed) Published
Abstract [en]

Introduction: Iodine is essential for normal brain development. Moderate and severe fetal iodine deficiency results in substantial to serious developmental delay in children. Mild iodine deficiency in pregnancy is associated with neurodevelopmental deficits in the offspring, but evidence from randomised trials is lacking. The aim of the Swedish Iodine in Pregnancy and Development in Children study is to determine the effect of daily supplementation with 150 µg iodine during pregnancy on the offspring’s neuropsychological development up to 14 years of age.

Methods and analysis: Thyroid healthy pregnant women (n=1275: age range 18–40 years) at ≤12 weeks gestation will be randomly assigned to receive multivitamin supplements containing 150 µg iodine or non-iodine-containing multivitamin daily throughout pregnancy. As a primary outcome, IQ will be measured in the offspring at 7 years (Wechsler Intelligence Scale for Children-V). As secondary outcomes, IQ will be measured at 3.5 and 14 years, psychomotor development at 18 months and 7 years, and behaviour at 3.5, 7 and 14 years. Iodine status (urinary iodine concentration) will be measured during pregnancy and in the offspring at 3.5, 7 and 14 years. Thyroid function (thyroid hormones, thyroglobulin), and deiodinase type 2 polymorphisms will be measured during pregnancy and in the offspring at 7 and 14 years. Structural MRI or other relevant structural or functional brain imaging procedures will be performed in a subgroup of children at 7 and 14 years. Background and socioeconomic information will be collected at all follow-up times.

Ethics and dissemination: This study is approved by the Ethics Committee in Göteborg, Sweden (Diary numbers: 431-12 approved 18 June 2012 (pregnancy part) and 1089-16 approved 8 February 2017 (children follow-up)). According to Swedish regulations, dietary supplements are governed by the National Food Agency and not by the Medical Product Agency. Therefore, there is no requirement for a monitoring committee and the National Food Agency does not perform any audits of trial conduct. The trial will be conducted in accordance with the Declaration of Helsinki. The participating sites will be contacted regarding important protocol changes, both orally and in writing, and the trial registry database will be updated accordingly. Study results will be presented at relevant conferences, and submitted to peer-reviewed journals with open access in the fields of endocrinology, paediatrics and nutrition. After the appropriate embargo period, the results will be communicated to participants, healthcare professionals at the maternal healthcare centres, the public and other relevant groups, such as the national guideline group for thyroid and pregnancy and the National Food Agency.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2018
National Category
Pediatrics
Identifiers
urn:nbn:se:umu:diva-151179 (URN)10.1136/bmjopen-2017-019945 (DOI)000435176700117 ()29643159 (PubMedID)
Available from: 2018-09-05 Created: 2018-09-05 Last updated: 2018-09-05Bibliographically approved
Chmielewska, A., Piescik-Lech, M., Shamir, R. & Szajewska, H. (2017). Systematic review: Early infant feeding practices and the risk of wheat allergy. Journal of Paediatrics and Child Health, 53(9), 889-896
Open this publication in new window or tab >>Systematic review: Early infant feeding practices and the risk of wheat allergy
2017 (English)In: Journal of Paediatrics and Child Health, ISSN 1034-4810, E-ISSN 1440-1754, Vol. 53, no 9, p. 889-896Article, review/survey (Refereed) Published
Abstract [en]

Aim: Wheat is a common allergen. Early feeding practices (breastfeeding, potentially allergenic foods) might affect the risk of allergy. To systematically evaluate the association between early feeding practices and the risk of wheat allergy and sensitisation. Methods: Five databases were searched for studies of any design up to July 2015. Results: We included seven studies (five observational, low to moderate quality, two randomised controlled trials (RCTs), high quality). The results come from observational studies unless stated otherwise. Longer breastfeeding was associated with wheat allergy (two studies,n = 1847) and sensitisation (one study, n = 3781). Evidence for exclusive breastfeeding was contradictory; longer exclusive breastfeeding wasassociated with either lower (one study, n = 408) or higher (one study, n = 3781) risk of wheat sensitisation. Breastfeeding at gluten introductiondid not affect the risk of wheat allergy (two studies, n = 2581). Introducing cereal ≥7 months of age increased the risk of wheat allergy (onestudy, n = 1612), but results from an RCT (n = 1303) showed no effect. Early introduction of gluten was associated with a reduced risk of wheat sensitisation up to 5 years in one observational study (n = 3781) but not in RCTs (n = 1303). Conclusions: Based on limited evidence, the influence of breastfeeding and an early exposure to gluten on the risk of wheat allergy remain uncertain. There is no evidence supporting breastfeeding at gluten introduction as modifying the risk. Early introduction of gluten might reducethe risk of sensitisation, but currently, no evidence exists that it affects the risk of wheat allergy.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017
Keywords
allergens, breastfeeding, child, glutens, infant, wheat hypersensitivity
National Category
Pediatrics
Identifiers
urn:nbn:se:umu:diva-139801 (URN)10.1111/jpc.13562 (DOI)000409042600011 ()
Available from: 2017-09-25 Created: 2017-09-25 Last updated: 2018-06-09Bibliographically approved
Chmielewska, A., Berglund, S., Lindberg, J., Mikael, N., Westrup, B. & Domellöf, M. (2016). HEAD GROWTH AND NEURODEVELOPMENT UNTIL 7 YEARS OF AGE: A STUDY IN LOW BIRTH WEIGHT INFANTS. Paper presented at The 6th Congress of the European Academy of Paediatric Societies, October 21-25, 2016, Geneva, Switzerland. EUROPEAN JOURNAL OF PEDIATRICS, 175(11), 1485-1485
Open this publication in new window or tab >>HEAD GROWTH AND NEURODEVELOPMENT UNTIL 7 YEARS OF AGE: A STUDY IN LOW BIRTH WEIGHT INFANTS
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2016 (English)In: EUROPEAN JOURNAL OF PEDIATRICS, ISSN 0340-6199, Vol. 175, no 11, p. 1485-1485Article in journal, Meeting abstract (Refereed) Published
Place, publisher, year, edition, pages
New York: Springer, 2016
National Category
Pediatrics
Identifiers
urn:nbn:se:umu:diva-130470 (URN)10.1007/s00431-016-2785-8 (DOI)000390040700279 ()
Conference
The 6th Congress of the European Academy of Paediatric Societies, October 21-25, 2016, Geneva, Switzerland
Available from: 2017-01-23 Created: 2017-01-20 Last updated: 2018-06-09Bibliographically approved
Chmielewska, A., Chmielewski, G., Domellöf, M., Lewandowski, Z. & Szajewska, H. (2015). Effect of iron supplementation on psychomotor development of non-anaemic, exclusively or predominantly breastfed infants: a randomised, controlled trial. BMJ Open, 5(11), Article ID e009441.
Open this publication in new window or tab >>Effect of iron supplementation on psychomotor development of non-anaemic, exclusively or predominantly breastfed infants: a randomised, controlled trial
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2015 (English)In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 5, no 11, article id e009441Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Uncertainty exists regarding the effects of iron supplementation during infancy on neurodevelopmental outcomes in the absence of anaemia. The aim of the study is to establish whether psychomotor and mental development is influenced by early iron supplementation in healthy, non-anaemic, exclusively or predominantly breastfed infants.

METHODS AND ANALYSIS: Healthy term infants will be recruited. If exclusively or predominantly breast fed (>50% of daily feedings) and not anaemic at 4 months, they will be randomised to receive either iron pyrophosphate (approximately 1 mg/kg) or placebo daily until 9 months of age. The primary outcome measure is neurodevelopment assessed with the Bayley Scales of Infant and Toddler Development (Bayley-III) at 12 months, and repeated at 24 and 36 months of age. Haematological parameters of iron metabolism also will be measured.

ETHICS AND DISSEMINATION: The Bioethics Committee of the Medical University of Warsaw approved the study protocol before recruitment started. Study results will be submitted to peer-reviewed journals in the fields of paediatrics and nutrition, and presented at relevant conferences.

TRIAL REGISTRATION NUMBER: NCT02242188.

National Category
Pediatrics
Identifiers
urn:nbn:se:umu:diva-118652 (URN)10.1136/bmjopen-2015-009441 (DOI)000368840100021 ()26603252 (PubMedID)
Available from: 2016-03-29 Created: 2016-03-29 Last updated: 2018-06-07Bibliographically approved
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