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Karlsson, Berndt
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Publications (10 of 23) Show all publications
Hermansson, J., Bøggild, H., Hallqvist, J., Karlsson, B., Knutsson, A., Nilsson, T., . . . Gillander Gådin, K. (2019). Interaction between Shift Work and Established Coronary Risk Factors. International Journal of Occupational and Environmental Medicine, 10(2), 57-65, Article ID 1466.
Open this publication in new window or tab >>Interaction between Shift Work and Established Coronary Risk Factors
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2019 (English)In: International Journal of Occupational and Environmental Medicine, ISSN 2008-6520, E-ISSN 2008-6814, Vol. 10, no 2, p. 57-65, article id 1466Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work.

OBJECTIVE: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction.

METHODS: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis.

RESULTS: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38).

CONCLUSION: Shift work and some established coronary risk factors have significant interactions.

Place, publisher, year, edition, pages
IJOEM, 2019
Keywords
Cardiovascular diseases, Epidemiology, Risk factors, Shift work schedule, Synergy
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-158677 (URN)10.15171/ijoem.2019.1466 (DOI)000466504000003 ()31041922 (PubMedID)
Available from: 2019-05-07 Created: 2019-05-07 Last updated: 2019-05-20Bibliographically approved
Hermansson, J., Hallqvist, J., Karlsson, B., Knutsson, A. & Gillander Gådin, K. (2018). Shift work, parental cardiovascular disease and myocardial infarction in males. Occupational Medicine, 68(2), 120-125
Open this publication in new window or tab >>Shift work, parental cardiovascular disease and myocardial infarction in males
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2018 (English)In: Occupational Medicine, ISSN 0962-7480, E-ISSN 1471-8405, Vol. 68, no 2, p. 120-125Article in journal (Refereed) Published
Abstract [en]

Background: Shift work has been associated with an increased risk of cardiovascular disease (CVD). However, there is a need for more studies to determine whether there is an interaction between shift work and other risk factors of CVD, thereby increasing the risk of CVD in shift workers. Aims: To discern whether shift work and parental mortality from myocardial infarction (MI) or sudden cardiac death (SCD) interact to increase the risk of MI in men. Methods: A case-control dataset was used to assess interaction between shift work and parental history of CVD, using death from MI or SCD, or death before age 65, on an additive scale. Results were reported as relative excess risk due to interaction, attributable proportion due to interaction (AP) and synergy index (SI). Results: There was an interaction between shift work and paternal mortality from MI or SCD, when both factors were present [SI = 2.39; 95% confidence interval (CI) 1.02. 5.6 and AP = 0.4; 95% CI 0.08. 0.73]. Conclusions: Paternal mortality from MI or SCD interacts with shift work to increase the risk of MI in men.

Place, publisher, year, edition, pages
Oxford University Press, 2018
Keywords
Cardiovascular disease, case-control study, heredity, interaction, risk factor
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-147358 (URN)10.1093/occmed/kqy008 (DOI)000429448800010 ()29444274 (PubMedID)
Available from: 2018-05-07 Created: 2018-05-07 Last updated: 2019-03-15Bibliographically approved
Mannelqvist, R., Karlsson, B. & Järvholm, B. (2016). Arbete och arbetsmarknad i sjukförsäkringen. Uppsala: Institutet för arbetsmarknads- och utbildningspolitisk utvärdering (IFAU)
Open this publication in new window or tab >>Arbete och arbetsmarknad i sjukförsäkringen
2016 (Swedish)Report (Refereed)
Place, publisher, year, edition, pages
Uppsala: Institutet för arbetsmarknads- och utbildningspolitisk utvärdering (IFAU), 2016. p. 60
Series
Institutet för arbetsmarknads- och utbildningspolitisk utvärdering (IFAU), Rapport, ISSN 1651-1158 ; 2016:6
Keywords
Sjukförsäkring, arbetsförmåga, arbetsmarknad, arbete
National Category
Law (excluding Law and Society)
Research subject
Law; Occupational and Environmental Medicine
Identifiers
urn:nbn:se:umu:diva-118516 (URN)
Projects
Arbete och arbetsmarknad i sjukförsäkringen
Funder
Institute for Evaluation of Labour Market and Education Policy (IFAU), 171/2012
Available from: 2016-03-22 Created: 2016-03-22 Last updated: 2018-06-07Bibliographically approved
Hermansson, J., Gillander Gådin, K., Karlsson, B., Reuterwall, C., Hallqvist, J. & Knutsson, A. (2015). Case fatality of myocardial infarction among shift workers. International Archives of Occupational and Environmental Health, 88(5), 599-605
Open this publication in new window or tab >>Case fatality of myocardial infarction among shift workers
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2015 (English)In: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 88, no 5, p. 599-605Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Shift work has been associated with an excess risk of cardiovascular disease (CVD) and more specifically myocardial infarction (MI). The majority of the studies that found a positive association between shift work and CVD have been based on incidence data. The results from studies on cardiovascular-related mortality among shift workers have shown little or no elevated mortality associated with shift work. None of the previous studies have analysed short-term mortality (case fatality) after MI. Therefore, we investigated whether shift work is associated with increased case fatality after MI compared with day workers.

METHODS: Data on incident cases with first MI were obtained from case-control study conducted in two geographical sites in Sweden (Stockholm Heart Epidemiology Program and Västernorrland Heart Epidemiology Program), including 1,542 cases (1,147 men and 395 women) of MI with complete working time information and 65 years or younger. Case fatality was defined as death within 28 days of onset of MI. Risk estimates were calculated using logistic regression.

RESULTS: The crude odds ratios for case fatality among male shift workers were 1.63 [95 % confidence interval (CI) 1.12, 2.38] and 0.56 (95 % CI 0.26, 1.18) for female shift workers compared with day workers. Adjustments for established cardiovascular risk factors such as diabetes type II and socio-economic status did not alter the results.

CONCLUSION: Shift work was associated with increased risk of case fatality among male shift workers after the first MI.

Place, publisher, year, edition, pages
Berlin Heidelberg: Springer Berlin/Heidelberg, 2015
Keywords
Cardiovascular disease, Case-control, Shift work, Risk estimation, Epidemiology
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-94352 (URN)10.1007/s00420-014-0984-z (DOI)000354624400007 ()25261317 (PubMedID)
Available from: 2014-10-08 Created: 2014-10-08 Last updated: 2018-06-07Bibliographically approved
Järvholm, B., Stattin, M., Robroek, S. J., Janlert, U., Karlsson, B. & Burdorf, A. (2014). Heavy work and disability pension: a long term follow-up of Swedish construction workers. Scandinavian Journal of Work, Environment and Health, 40(4), 335-342
Open this publication in new window or tab >>Heavy work and disability pension: a long term follow-up of Swedish construction workers
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2014 (English)In: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 40, no 4, p. 335-342Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: The objective of this study was to investigate the occurrence of disability pensions over time among workers with physically demanding jobs.

METHODS: The occurrence of disability pension was prospectively studied between 1980-2008 among 325 549 Swedish construction workers. The risks for disability pension and years lost of working life were compared among 22 occupational groups, adjusting for age, body mass index, height, and smoking habits.

RESULTS: The risk varied considerably among blue-collar workers. For example, rock workers had double the risk of disability pension [relative risk (RR) 2.16, 95% confidence interval (95% CI) 1.96-2.39] compared to electricians. Most working years lost due to disability pensions (about 75%) were found among men >50 years, mainly due to musculoskeletal and cardiovascular diseases. The years of working life lost due to disability pension varied from 0.7 (salaried employees) to 3.2 years (rock workers) among occupational groups.

CONCLUSION: Work environment is an important predictor for disability pension among construction workers with those in physically heavy jobs having the highest burden of disability. If the purpose is to increase labor force participation for workers with heavy jobs, strategies to reduce physical demands at work among elderly workers are important.

Place, publisher, year, edition, pages
Nordic Association of Occupational Safety and Health, 2014
Keywords
attributable risk, employability, epidemiology, insurance medicine, public health. Sweden
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-84978 (URN)10.5271/sjweh.3413 (DOI)000338614100002 ()24385007 (PubMedID)
Available from: 2014-01-24 Created: 2014-01-24 Last updated: 2018-06-08Bibliographically approved
Knutsson, A., Alfredsson, L., Karlsson, B., Åkerstedt, T., Fransson, E. I., Westerholm, P. & Westerlund, H. (2013). Breast cancer among shift workers: results of the WOLF longitudinal cohort study. Scandinavian Journal of Work, Environment and Health, 39(2), 170-177
Open this publication in new window or tab >>Breast cancer among shift workers: results of the WOLF longitudinal cohort study
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2013 (English)In: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 39, no 2, p. 170-177Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The aim of this study was to investigate whether shift work (with or without night work) is associated with increased risk of breast cancer.

METHODS: The population consisted of 4036 women. Data were obtained from WOLF (Work, Lipids, and Fibrinogen), a longitudinal cohort study. Information about baseline characteristics was based on questionnaire responses and medical examination. Cancer incidence from baseline to follow-up was obtained from the national cancer registry. Two exposure groups were identified: shift work with and without night work. The group with day work only was used as the reference group in the analysis. Cox regression analysis was used to calculate relative risk.

RESULTS: In total, 94 women developed breast cancer during follow-up. The average follow-up time was 12.4 years. The hazard ratio for breast cancer was 1.23 [95% confidence interval (95% CI) 0.70-2.17] for shifts without night work and 2.02 (95% CI 1.03-3.95) for shifts with night work. When including only women >60 years of age, the risk estimates were 1.18 (95% CI 0.67-2.07) for shifts without night work, and 2.15 (95% CI 1.10-4.21) for shifts with night work.

CONCLUSIONS: Our results indicate an increased risk for breast cancer among women who work shifts that includes night work.

Keywords
chronodisruption; circadian rhythm; Cox regression; melatonin; neoplasm; night work; shift work
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-60048 (URN)10.5271/sjweh.3323 (DOI)000332916000007 ()23007867 (PubMedID)
Available from: 2012-10-01 Created: 2012-10-01 Last updated: 2018-06-08Bibliographically approved
Andersson, E., Murgia, N., Nilsson, T., Karlsson, B. & Torén, K. (2013). Incidence of chronic bronchitis in a cohort of pulp mill workers with repeated gassings to sulphur dioxide and other irritant gases. Environmental health, 12, Article ID 113.
Open this publication in new window or tab >>Incidence of chronic bronchitis in a cohort of pulp mill workers with repeated gassings to sulphur dioxide and other irritant gases
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2013 (English)In: Environmental health, ISSN 1476-069X, E-ISSN 1476-069X, Vol. 12, article id 113Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Occupational exposure to irritants is associated with chronic bronchitis. The aim of this study was to elucidate whether repeated peak exposures with respiratory symptoms, gassings, to sulphur dioxide (SO2) and other irritant gases could increase the risk of chronic bronchitis.

METHODS: The study population comprised 3,060 Swedish pulp mill workers (84% males) from a cohort study, who completed a comprehensive questionnaire with items on chronic bronchitis symptoms, smoking habit, occupational history, and specific exposures, including gassings. 2,037 have worked in sulphite mills. Incidence rates and hazard ratios (HRs) for the observation period, 1970-2000, in relation to exposure and the frequency of repeated gassings to SO2 and other irritant gases were calculated.

RESULTS: The incidence rate for chronic bronchitis among workers with repeated gassings was 3.5/1,000 person-years compared with 1.5/1,000 person-years among unexposed workers (HR 2.1, 95% confidence interval (CI) 1.4-3.1). The risk was even higher in the subgroup with frequent gassings (HR 3.2, 95% CI 2.0-5.2), particularly among never-smokers (HR 8.7, 95% CI 3.5-22).

CONCLUSIONS: Repeated gassings to irritant gases increased the incidence of chronic bronchitis in our study population during and after work in pulp mills, supporting the hypothesis that occupational exposures to irritants negatively affect the airways. These results underscore the importance of preventive actions in this work environment.

Place, publisher, year, edition, pages
BioMed Central, 2013
Keywords
(MeSH), Bronchitis, Chronic, Irritants, Sulphur dioxide, Paper
National Category
Occupational Health and Environmental Health Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-84977 (URN)10.1186/1476-069X-12-113 (DOI)000330285600001 ()24354705 (PubMedID)
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare
Available from: 2014-01-24 Created: 2014-01-24 Last updated: 2018-06-08Bibliographically approved
Garde, A. H., Karlsson, B., Hansen, Å. M., Persson, R. & Åkerstedt, T. (2012). Sleep and Salivary Cortisol. In: Margareta Kristenson, Peter Garvin, Ulf Lundberg (Ed.), The Role of Saliva Cortisol Measurement in Health and Disease (pp. 116-128). Bentham eBooks
Open this publication in new window or tab >>Sleep and Salivary Cortisol
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2012 (English)In: The Role of Saliva Cortisol Measurement in Health and Disease / [ed] Margareta Kristenson, Peter Garvin, Ulf Lundberg, Bentham eBooks, 2012, p. 116-128Chapter in book (Other academic)
Abstract [en]

The aim of the present chapter was to analyze whether measures of cortisol in saliva were associated with measures of sleep and to explore if divergent results were related to underlying differences in theoretic assumptions and methods. Measures of sleep quality included sleep duration, overall sleep quality, difficulty falling asleep, disturbed sleep, and sleep deprivation. Twenty-three papers were found to fulfil the inclusion criteria. Cortisol measures were grouped into single time points at different times during the day, deviations at different time periods during the day, reactivity and recovery after a standardized laboratory test, area under the curve and response to dexamethasone test. A large proportion of the studies included showed nonsignificant findings, which, in several cases, may be a result of low power. The most consistent results were a positive association between sleep duration and single measures of salivary cortisol at awakening, which was observed in 3 studies. In these studies, sleep duration was also associated with low evening cortisol levels, steep diurnal deviation of cortisol and/or high area under the curve. Together these findings suggest that longer sleep duration is related to a more dynamic cortisol secretion. Two of the 6 studies on disturbed or restless sleep showed relations to flat diurnal deviation and low laboratory stress test reactivity. This to some extent corroborates the findings on sleep duration. However, the many nonsignificant findings as well as the theoretical and methodological differences (e.g., heterogeneity in measures) complicate comparisons. Conflicting results may be at least partially due to differences in methods and underlying assumptions.

Place, publisher, year, edition, pages
Bentham eBooks, 2012
Keywords
Salivary cortisol, sleep, sleep quality, sleep duration, sleep deprivation, difficulty falling asleep, single time point measures, deviations measures, area under the curve, dexamethasone
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-55544 (URN)10.2174/978160805342111201010116 (DOI)978-1-60805-342-1 (ISBN)
Available from: 2012-05-29 Created: 2012-05-21 Last updated: 2018-06-08Bibliographically approved
Mannelqvist, R., Karlsson, B. & Järvholm, B. (2010). Läkarintyg om bedömning av arbetsförmåga klarar inte alltid rättslig prövning.. Läkartidningen, 107(49), 3125-3127
Open this publication in new window or tab >>Läkarintyg om bedömning av arbetsförmåga klarar inte alltid rättslig prövning.
2010 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 107, no 49, p. 3125-3127Article in journal (Refereed) Published
Keywords
arbetsförmåga, läkarintyg, sjukförsäkring
National Category
Law (excluding Law and Society) Occupational Health and Environmental Health
Research subject
Law; Medicine
Identifiers
urn:nbn:se:umu:diva-38345 (URN)
Projects
Arbetsförmåga ur rättsligt och medicinskt perspektiv
Available from: 2010-12-08 Created: 2010-12-08 Last updated: 2018-06-08Bibliographically approved
Mannelqvist, R., Karlsson, B. & Järvholm, B. (2010). Sickness certificates as a basis for decisions regarding work capacity not always sufficient for legal trials: Difficult for the physician to understand law--and for the lawyer to understand medicine. Läkartidningen, 107(49), 3125-3127
Open this publication in new window or tab >>Sickness certificates as a basis for decisions regarding work capacity not always sufficient for legal trials: Difficult for the physician to understand law--and for the lawyer to understand medicine
2010 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 107, no 49, p. 3125-3127Article in journal (Refereed) Published
Abstract [sv]

I en studie av arbetsförmågebegreppet i sjukförsäkringen har medicinska intyg som använts i förvaltningsdomstol granskats.

Intygens kvalitet och hur de använts och tolkats i domstolarna har kartlagts. Huvudsakligen beskrevs patientens funktionsförmåga i intygen, och kvaliteten på dessa uppgifter var i allmänhet god.

I fyra av fem intyg saknades där­emot beskrivning av arbetets krav och bedömning av sambandet mellan funktionsförmåga och arbetets krav.

I domstolen hänvisades ofta till en samlad bedömning av den medicinska utredningen, och det framgick i mycket få fall om och hur domstolen valt att värdera olika intyg.

Vidare saknades koppling mellan intyg av god kvalitet och domstolens bedömning; intyg av dålig kvalitet behövde inte innebära att patienten förlorade sin rätt till ersättning i domstolen och intyg av god kvalitet övertygade inte alltid domstolen.

Detta kan bero på att läkaren inte alltid förstår de rättsliga kraven på intygen eller att juristen inte förstår den medi­cinska informationen.

Keywords
Adolescent, Adult, Age Distribution, Cerebrovascular Accident/*mortality, Child, Cohort Studies, Coronary Disease/*mortality, Diabetes Mellitus/*mortality, Humans, Male, Middle Aged, Occupational Health, Paper, Sweden/epidemiology, Work Schedule Tolerance
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-65901 (URN)21280342 (PubMedID)
Available from: 2013-02-13 Created: 2013-02-13 Last updated: 2018-06-08Bibliographically approved
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