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Jia, Xueen
Publications (10 of 10) Show all publications
Horvath, I., Jia, X., Johansson, P., Wang, C., Moskalenko, R., Steinau, A., . . . Morozova-Roche, L. A. (2016). Pro-inflammatory S100A9 Protein as a Robust Biomarker Differentiating Early Stages of Cognitive Impairment in Alzheimer's Disease [Letter to the editor]. ACS Chemical Neuroscience, 7(1), 34-39
Open this publication in new window or tab >>Pro-inflammatory S100A9 Protein as a Robust Biomarker Differentiating Early Stages of Cognitive Impairment in Alzheimer's Disease
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2016 (English)In: ACS Chemical Neuroscience, ISSN 1948-7193, E-ISSN 1948-7193, Vol. 7, no 1, p. 34-39Article in journal, Letter (Refereed) Published
Abstract [en]

Pro-inflammatory protein S100A9 was established as a biomarker of dementia progression and compared with others such as Aβ1-42 and tau-proteins. CSF samples from 104 stringently diagnosed individuals divided into five subgroups were analyzed, including nondemented controls, stable mild cognitive impairment (SMCI), mild cognitive impairment due to Alzheimer's disease (MCI-AD), Alzheimer's disease (AD), and vascular dementia (VaD) patients. ELISA, dot-blotting, and electrochemical impedance spectroscopy were used as research methods. The S100A9 and Aβ1-42 levels correlated with each other: their CSF content decreased already at the SMCI stage and declined further under MCI-AD, AD, and VaD conditions. Immunohistochemical analysis also revealed involvement of both Aβ1-42 and S100A9 in the amyloid-neuroinflammatory cascade already during SMCI. Tau proteins were not yet altered in SMCI; however their contents increased during MCI-AD and AD, diagnosing later dementia stages. Thus, four biomarkers together, reflecting different underlying pathological causes, can accurately differentiate dementia progression and also distinguish AD from VaD.

Keywords
Alzheimer’s disease, mild cognitive impairment, cerebrospinal fluid, S100A9, Aβ1−42, biomarkers, amyloid, inflammation
National Category
Neurosciences
Identifiers
urn:nbn:se:umu:diva-111351 (URN)10.1021/acschemneuro.5b00265 (DOI)000368567200006 ()26550994 (PubMedID)
Available from: 2015-11-13 Created: 2015-11-13 Last updated: 2018-06-07Bibliographically approved
Sharifi, T., Gracia-Espino, E., Jia, X., Sandström, R. & Wågberg, T. (2015). Comprehensive study of an earth-abundant bifunctional 3D electrode for efficient water electrolysis in alkaline medium. ACS Applied Materials and Interfaces, 7(51), 28148-28155
Open this publication in new window or tab >>Comprehensive study of an earth-abundant bifunctional 3D electrode for efficient water electrolysis in alkaline medium
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2015 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 7, no 51, p. 28148-28155Article in journal (Refereed) Published
Abstract [en]

We report efficient electrolysis of both water splitting half reactions in the same medium by a bifunctional 3D electrode comprising Co3O4 nanospheres nucleated on the surface of nitrogen-doped carbon nanotubes (NCNTs) that in turn are grown on conductive carbon paper (CP). The resulting electrode exhibits high stability and large electrochemical activity for both oxygen and hydrogen evolution reactions (OER and HER). We obtain a current density of 10 mA/cm(2) in 0.1 M KOH solution at overpotentials of only 0.47 and 0.38 V for OER and HER, respectively. Additionally, the experimental observations are understood and supported by analyzing the Co3O4:NCNT and NCNT:CP interfaces by ab initio calculations. Both the experimental and the theoretical studies indicate that firm and well-established interfaces along the electrode play a crucial role on the stability and electrochemical activity for both OER and HER.

Place, publisher, year, edition, pages
Washington: American Chemical Society (ACS), 2015
Keywords
water splitting, bifunctional catalyst, oxygen evolution reaction, hydrogen evolution reaction, transition metal oxides, nitrogen-doped carbon nanotubes
National Category
Condensed Matter Physics Nano Technology
Identifiers
urn:nbn:se:umu:diva-117855 (URN)10.1021/acsami.5b10118 (DOI)000369448200021 ()26629887 (PubMedID)
Available from: 2016-03-16 Created: 2016-03-04 Last updated: 2018-06-07Bibliographically approved
Gracia-Espino, E., Jia, X. & Wågberg, T. (2014). Improved oxygen reduction performance of Pt–Ni nanoparticles by adhesion on nitrogen-doped graphene. The Journal of Physical Chemistry C, 118(5), 2804-2811
Open this publication in new window or tab >>Improved oxygen reduction performance of Pt–Ni nanoparticles by adhesion on nitrogen-doped graphene
2014 (English)In: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455, Vol. 118, no 5, p. 2804-2811Article in journal (Refereed) Published
Abstract [en]

Graphene and its derivatives hold great potential as support for nanocatalyst in various energy applications, such as fuel cells, batteries, and capacitors. In this work, we used density functional theory to analyze substrate effect on the electrocatalytic activity of Pt–Ni bimetallic nanoparticles for oxygen reduction reaction (ORR). The dissociative mechanism is used to evaluate the ORR performance (energy barrier for O2 dissociation, free energy of intermediates, d-band center, overpotential, and electrochemical activity) for a Pt–Ni core–shell-like nanoparticle (PtNiCS) deposited on nondefective graphene (GS) or nitrogen-doped graphene (N-GS). The electronic and catalytic properties of PtNiCS on N-GS designate N-doped graphene as the best substrate to use for ORR, showing better interaction with the bimetallic cluster, improved charge transfer between constitutes, and a superior ORR performance when compared to PtNiCS on GS. The N-GS has a significant effect in reducing the energy barrier for O2 dissociation and decrease the energetic stability of HO* intermediates, resulting in enhanced ORR activity compared with the PtNiCS on GS. In addition, the strong interaction between PtNiCS cluster and N-GS substrate may lead to an improved long-term stability of the catalytic particle during ORR cycles.

National Category
Nano Technology
Research subject
Materials Science
Identifiers
urn:nbn:se:umu:diva-85455 (URN)10.1021/jp4101619 (DOI)000331153700064 ()
Available from: 2014-02-04 Created: 2014-02-04 Last updated: 2019-10-17Bibliographically approved
Barzegar, H. R., Hu, G., Larsen, C., Jia, X., Edman, L. & Wågberg, T. (2014). Palladium nanocrystals supported on photo-transformed C-60 nanorods: effect of crystal morphology and electron mobility on the electrocatalytic activity towards ethanol oxidation. Carbon, 73, 34-40
Open this publication in new window or tab >>Palladium nanocrystals supported on photo-transformed C-60 nanorods: effect of crystal morphology and electron mobility on the electrocatalytic activity towards ethanol oxidation
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2014 (English)In: Carbon, ISSN 0008-6223, E-ISSN 1873-3891, Vol. 73, p. 34-40Article in journal (Refereed) Published
Abstract [en]

We report on the synthesis and decoration of high-aspect-ratio crystalline C-60 nanorods (NRs) by functionalized palladium nanoparticles with an average size of 4.78 +/- 0.66 nm. In their pristine form, C-60 NRs suffer from partial damage in the solution-based decoration process resulting in poor crystallinity. However, by modifying the NR surface via in situ photochemical transformation in the liquid state, we are able to prepare highly stable NRs that retain their crystalline structure during the decoration process. Our method thus opens up for the synthesis of highly crystalline nanocomposite hybrids comprising Pd nanoparticles and C-60 NRs. Bys measuring the electron mobility of different C-60 NRs, we relate both the effect of electron mobility and crystallinity to the final electrocatalytic performance of the synthesized hybrid structures. We show that the photo-transformed C-60 NRs exhibit highly advantageous properties for ethanol oxidation based on both a better crystallinity and a higher bulk conductivity. These findings give important information in the search for efficient catalyst support.

National Category
Physical Chemistry Nano Technology
Identifiers
urn:nbn:se:umu:diva-97292 (URN)10.1016/j.carbon.2014.02.028 (DOI)000335096300004 ()
Available from: 2014-12-12 Created: 2014-12-12 Last updated: 2018-06-07Bibliographically approved
Hu, G., Nitze, F., Jia, X., Sharifi, T., Barzegar, H. R., Gracia-Espino, E. & Wågberg, T. (2014). Reduction free room temperature synthesis of a durable and efficient Pd/ordered mesoporous carbon composite electrocatalyst for alkaline direct alcohols fuel cell. RSC Advances, 4(2), 676-682
Open this publication in new window or tab >>Reduction free room temperature synthesis of a durable and efficient Pd/ordered mesoporous carbon composite electrocatalyst for alkaline direct alcohols fuel cell
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2014 (English)In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 4, no 2, p. 676-682Article in journal (Refereed) Published
Abstract [en]

The development of easy and environmentally benign synthesis methods of efficient electrocatalysts for use in energy conversion applications motivates researchers all over the world. Here we report a novel and versatile method to synthesize well-dispersed palladium-functionalized ordered mesoporous carbons (Pd/OMCs) at room temperature without any reducing agent by one-pot mixing of tri(dibenzylideneacetone)palladium(0) (Pd2DBA3) and OMCs together in a common N,N-dimethylformamide (DMF) solution. The formation of Pd nanoparticles and their crystallization on the OMC is catalyzed by protons in the solution and can thus be controlled by the solution pH. The complete process and the as-prepared nanocomposite was characterized by UV-spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (HTEM), X-ray photoelectron spectrum (XPS), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The electrocatalytic property of the as-decorated material was examined with cyclic voltammetry (CV). The Pd/OMC composite shows up to two times higher electrocatalytic ability with a significantly better durability towards ethanol and methanol oxidation in alkaline media compared to commercial high surface area conductive carbon black Vulcan XC-72 decorated with equivalent Pd nanoparticles. Our described method provides new insight for the development of highly efficient carbon based nanocatalysts by simple and environmentally sound methods.

Place, publisher, year, edition, pages
RSC Publishing, 2014
National Category
Nano Technology
Identifiers
urn:nbn:se:umu:diva-81571 (URN)10.1039/C3RA42652A (DOI)000327849700024 ()
Available from: 2013-11-01 Created: 2013-10-16 Last updated: 2019-10-17Bibliographically approved
Wang, C., Klechikov, A. G., Gharibyan, A. L., Wärmländer, S. K. T., Jarvet, J., Zhao, L., . . . Morozova-Roche, L. A. (2014). The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade. Acta Neuropathologica, 127(4), 507-522
Open this publication in new window or tab >>The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade
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2014 (English)In: Acta Neuropathologica, ISSN 0001-6322, E-ISSN 1432-0533, Vol. 127, no 4, p. 507-522Article in journal (Refereed) Published
Abstract [en]

Pro-inflammatory S100A9 protein is increasingly recognized as an important contributor to inflammation-related neurodegeneration. Here, we provide insights into S100A9 specific mechanisms of action in Alzheimer's disease (AD). Due to its inherent amyloidogenicity S100A9 contributes to amyloid plaque formation together with A beta. In traumatic brain injury (TBI) S100A9 itself rapidly forms amyloid plaques, which were reactive with oligomer-specific antibodies, but not with A beta and amyloid fibrillar antibodies. They may serve as precursor-plaques for AD, implicating TBI as an AD risk factor. S100A9 was observed in some hippocampal and cortical neurons in TBI, AD and non-demented aging. In vitro S100A9 forms neurotoxic linear and annular amyloids resembling A beta protofilaments. S100A9 amyloid cytotoxicity and native S100A9 pro-inflammatory signaling can be mitigated by its co-aggregation with A beta, which results in a variety of micron-scale amyloid complexes. NMR and molecular docking demonstrated transient interactions between native S100A9 and A beta. Thus, abundantly present in AD brain pro-inflammatory S100A9, possessing also intrinsic amyloidogenic properties and ability to modulate A beta aggregation, can serve as a link between the AD amyloid and neuroinflammatory cascades and as a prospective therapeutic target.

Keywords
A beta, Alzheimer's disease, Amyloid, Cytotoxicity, Neuroinflammation, S100A9, Traumatic brain injury
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
urn:nbn:se:umu:diva-88313 (URN)10.1007/s00401-013-1208-4 (DOI)000332957400004 ()
External cooperation:
Note

Erratum available at http://dx.doi.org/10.1007/s00401-014-1316-9

Available from: 2014-06-17 Created: 2014-04-30 Last updated: 2018-06-07Bibliographically approved
Sharifi, T., Gracia-Espino, E., Barzegar, H. R., Jia, X., Nitze, F., Hu, G., . . . Wågberg, T. (2013). Formation of nitrogen-doped graphene nanoscrolls by adsorption of magnetic gamma-Fe2O3 nanoparticles. Nature Communications, 4, 2319
Open this publication in new window or tab >>Formation of nitrogen-doped graphene nanoscrolls by adsorption of magnetic gamma-Fe2O3 nanoparticles
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2013 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 4, p. 2319-Article in journal (Refereed) Published
Abstract [en]

Graphene nanoscrolls are Archimedean-type spirals formed by rolling single-layer graphene sheets. Their unique structure makes them conceptually interesting and understanding their formation gives important information on the manipulation and characteristics of various carbon nanostructures. Here we report a 100% efficient process to transform nitrogen-doped reduced graphene oxide sheets into homogeneous nanoscrolls by decoration with magnetic gamma-Fe2O3 nanoparticles. Through a large number of control experiments, magnetic characterization of the decorated nanoparticles, and ab initio calculations, we conclude that the rolling is initiated by the strong adsorption of maghemite nanoparticles at nitrogen defects in the graphene lattice and their mutual magnetic interaction. The nanoscroll formation is fully reversible and upon removal of the maghemite nanoparticles, the nanoscrolls return to open sheets. Besides supplying information on the rolling mechanism of graphene nanoscrolls, our results also provide important information on the stabilization of iron oxide nanoparticles.

Place, publisher, year, edition, pages
Nature Publishing Group, 2013
National Category
Physical Sciences Chemical Sciences
Identifiers
urn:nbn:se:umu:diva-80760 (URN)10.1038/ncomms3319 (DOI)000323752300004 ()
Available from: 2013-10-03 Created: 2013-09-25 Last updated: 2018-06-08Bibliographically approved
Jia, X., Hu, G., Nitze, F., Barzegar, H. R., Sharifi, T., Tai, C.-W. & Wågberg, T. (2013). Synthesis of Palladium/Helical Carbon Nanofiber Hybrid Nanostructures and Their Application for Hydrogen Peroxide and Glucose Detection. ACS Applied Materials and Interfaces, 5(22), 12017-12022
Open this publication in new window or tab >>Synthesis of Palladium/Helical Carbon Nanofiber Hybrid Nanostructures and Their Application for Hydrogen Peroxide and Glucose Detection
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2013 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 5, no 22, p. 12017-12022Article in journal (Refereed) Published
Abstract [en]

We report on a novel sensing platform for H2O2 and glucose based on immobilization of palladium-helical carbon nanofiber (Pd-HCNF) hybrid nanostnictures and glucose oxidase (GOx) with Nafion on a glassy carbon electrode (GCE). HCNFs were synthesized by a chemical vapor deposition process on a C-60-supported Pd catalyst. Pd-HCNF nanocomposites were prepared by a one-step reduction free method in dimethylformamide (DMF). The prepared materials were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Raman spectroscopy. The Nafion/Pd-HCNF/GCE sensor exhibits excellent electrocatalytic sensitivity toward H2O2 (315 mA M-1 cm(-2)) as probed by cyclic voltammetry (CV) and chronoamperometry. We show that Pd-HCNF-modified electrodes significantly reduce the overpotential and enhance the electron transfer rate. A linear range from 5.0 mu M to 2.1 mM with a detection limit of 3.0 mu M (based on the S/N = 3) and good reproducibility were obtained. Furthermore, a sensing platform for glucose was prepared by immobilizing the Pd-HCNFs and glucose oxidase (GOx) with Nafion on a glassy carbon electrode. The resulting biosensor exhibits a good response to glucose with a wide linear range (0.06-6.0 mM) with a detection limit of 0.03 mM and a sensitivity of 13 mA M-1 cm(-2). We show that small size and homogeneous distribution of the Pd nanoparticles in combination with good conductivity and large surface area of the HCNFs lead to a H2O2 and glucose sensing platform that performs in the top range of the herein reported sensor platforms.

Keywords
hydrogen peroxide, glucose, helical carbon nanofibers, palladium, Nafion, nanoparticles, biosensors
National Category
Nano Technology Physical Sciences
Identifiers
urn:nbn:se:umu:diva-85100 (URN)10.1021/am4037383 (DOI)000327812300072 ()
Funder
Swedish Research Council, dnr-2010 3973
Available from: 2014-01-28 Created: 2014-01-28 Last updated: 2018-06-08Bibliographically approved
Sharifi, T., Hu, G., Jia, X. & Wågberg, T. (2012). Formation of active sites for Oxygen reduction reactions by transformation of Nitrogen functionalities in Nitrogen-doped Carbon nanotubes. ACS Nano, 6(10), 8904-8912
Open this publication in new window or tab >>Formation of active sites for Oxygen reduction reactions by transformation of Nitrogen functionalities in Nitrogen-doped Carbon nanotubes
2012 (English)In: ACS Nano, ISSN 1936-0851, E-ISSN 1936-086X, Vol. 6, no 10, p. 8904-8912Article in journal (Refereed) Published
Abstract [en]

Heat treating nitrogen-doped multiwalled carbon nanotubes containing up to six different types of nitrogen functionalities transforms particular nitrogen functionalities into other types which are more catalytically active toward oxygen reduction reactions (ORR). In the first stage, the unstable pyrrolic functionalities transform into pyridinic functionalities followed by an immediate transition into quaternary center and valley nitrogen functionalities. By measuring the electrocatalytic oxidation reduction current for the different samples, we achieve information on the catalytic activity connected to each type of nitrogen functionality. Through this, we conclude that quaternary nitrogen valley sites, N-Q(valley), are the most active sites for ORR in N-CNTs. The number of electrons transferred in the ORR is determined from ring disk electrode and rotating ring disk electrode measurements. Our measurements indicate that the ORR processes proceed by a direct four-electron pathway for the N-Q(valley) and the pyridinic sites while it proceeds by an indirect two-electron pathway via hydrogen peroxide at the N-Q(center) sites. Our study gives both insights on the mechanism of ORR on different nitrogen functionalities in nitrogen-doped carbon nanostructures and it proposes how to treat samples to maximize the catalytic efficiency of such samples.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2012
Keywords
nitrogen-doped carbon nanotubes, nitrogen functionalities, X-ray photoelectron spectroscopy, electrochemistry, cyclic voltammetry, oxygen reduction reactions
National Category
Physical Sciences Chemical Sciences Nano Technology
Identifiers
urn:nbn:se:umu:diva-61776 (URN)10.1021/nn302906r (DOI)000310096100049 ()
Available from: 2012-11-27 Created: 2012-11-26 Last updated: 2018-06-08Bibliographically approved
Jia, X., Gharibyan, A., Öhman, A., Liu, Y., Olofsson, A. & Morozova-Roche, L. A. (2011). Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity. Journal of Molecular Biology, 414(5), 699-712
Open this publication in new window or tab >>Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity
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2011 (English)In: Journal of Molecular Biology, ISSN 0022-2836, E-ISSN 1089-8638, Vol. 414, no 5, p. 699-712Article in journal (Refereed) Published
Abstract [en]

Parkinson's disease is a common neurodegenerative disorder characterized by α-synuclein (α-Syn)-containing Lewy body formation and selective loss of dopaminergic neurons in the substantia nigra. We have demonstrated the modulating effect of noopept, a novel proline-containing dipeptide drug with nootropic and neuroprotective properties, on α-Syn oligomerization and fibrillation by using thioflavin T fluorescence, far-UV CD, and atomic force microscopy techniques. Noopept does not bind to a sterically specific site in the α-Syn molecule as revealed by heteronuclear two-dimensional NMR analysis, but due to hydrophobic interactions with toxic amyloid oligomers, it prompts their rapid sequestration into larger fibrillar amyloid aggregates. Consequently, this process rescues the cytotoxic effect of amyloid oligomers on neuroblastoma SH-SY5Y cells as demonstrated by using cell viability assays and fluorescent staining of apoptotic and necrotic cells and by assessing the level of intracellular oxidative stress. The mitigating effect of noopept against amyloid oligomeric cytotoxicity may offer additional benefits to the already well-established therapeutic functions of this new pharmaceutical.

Keywords
α-synuclein, noopept, amyloid, cytotoxicity, Parkinson's disease
National Category
Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-50073 (URN)10.1016/j.jmb.2011.09.044 (DOI)000298526800005 ()21986202 (PubMedID)
Available from: 2011-11-24 Created: 2011-11-24 Last updated: 2018-06-08Bibliographically approved
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