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Shayesteh, AlexanderORCID iD iconorcid.org/0000-0003-0700-7195
Alternative names
Publications (10 of 22) Show all publications
Alsterholm, M., af Klinteberg, M., Vrang, S., Sigurdardottir, G., Sandström Falk, M. & Shayesteh, A. (2025). Topical steroid withdrawal in atopic dermatitis: patient-reported characterization from a Swedish social media questionnaire. Acta Dermato-Venereologica, 105, Article ID adv40187.
Open this publication in new window or tab >>Topical steroid withdrawal in atopic dermatitis: patient-reported characterization from a Swedish social media questionnaire
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2025 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 105, article id adv40187Article in journal (Refereed) Published
Abstract [en]

Topical steroid withdrawal (TSW) is described as an adverse reaction to topical glucocorticoids (TGCs). A pathophysiological mechanism has not been identified. There are no diagnostic criteria. The aim was to describe patient-reported characteristics of TSW in atopic dermatitis (AD). An observational cross-sectional study was performed by posting a questionnaire for participants, aged ≥18 years, reporting both AD and TSW, in a Swedish TSW-themed Facebook group during 4 weeks in 2023. The questionnaire was accessed by 98 participants, with 82 completing it. Most were female (95%), 18-39 years old (74%), self-diagnosed with TSW (84%), and reported current symptoms of AD and TSW. They defined TSW as dependency on TGCs and adverse reactions to their use. Erythema, desquamation, dryness, and oozing affecting the face, neck, and upper extremities were the most reported signs. Pruritus, sleep disturbance, and signs of anxiety and depression were the most reported symptoms. Recurring episodes of manifestations attributed to TSW were reported by 60%. The personal trigger factor was believed to be TGCs by 93%, and 33% also identified oral glucocorticoids. TGCs were currently used by 21%. Self-reported manifestations of TSW are similar to those of AD but appeared to be distinguishable for the participants and caused considerable morbidity.

Place, publisher, year, edition, pages
Medical Journals Sweden, 2025
Keywords
atopic dermatitis, red skin syndrome, topical steroid addiction, topical steroid withdrawal, topical steroid withdrawal syndrome
National Category
Dermatology and Venereal Diseases
Identifiers
urn:nbn:se:umu:diva-234320 (URN)10.2340/actadv.v105.40187 (DOI)39749386 (PubMedID)2-s2.0-85214590123 (Scopus ID)
Available from: 2025-01-22 Created: 2025-01-22 Last updated: 2025-01-22Bibliographically approved
Stjernbrandt, A.-L., Burstedt, M., Holmbom, E. & Shayesteh, A. (2024). Acral peeling skin syndrome: two unusual cases and the therapeutic potential of botulinum toxin. Acta Dermato-Venereologica, 104, Article ID adv24305.
Open this publication in new window or tab >>Acral peeling skin syndrome: two unusual cases and the therapeutic potential of botulinum toxin
2024 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 104, article id adv24305Article in journal (Refereed) Published
Abstract [en]

No abstract available

Place, publisher, year, edition, pages
Uppsala: Medical Journals Sweden, 2024
Keywords
Acral Peeling Skin Syndrome, genetic counseling, botulinumtoxin, case-reports
National Category
Dermatology and Venereal Diseases
Research subject
Dermatology and Venerology; Clinical Genetics
Identifiers
urn:nbn:se:umu:diva-223205 (URN)10.2340/actadv.v104.24305 (DOI)2-s2.0-85190342839 (Scopus ID)
Available from: 2024-04-11 Created: 2024-04-11 Last updated: 2024-04-24Bibliographically approved
Dahlberg, J., Nylander, E., Persson, M. & Shayesteh, A. (2024). An uncertain uphill battle: experiences and consequences of living with lipedema. International Journal of Qualitative Studies on Health and Well-being, 19(1), Article ID 2300152.
Open this publication in new window or tab >>An uncertain uphill battle: experiences and consequences of living with lipedema
2024 (English)In: International Journal of Qualitative Studies on Health and Well-being, ISSN 1748-2623, E-ISSN 1748-2631, Vol. 19, no 1, article id 2300152Article in journal (Refereed) Published
Abstract [en]

Purpose: To describe and analyse experiences of living with lipedema. Methods: Individual, semi-structured interviews with a purposive sample of 12 women diagnosed with lipedema and analysed by qualitative content analysis utilizing an inductive approach.

Results: The overarching theme, “An uncertain uphill battle against a divergent body and societal ignorance”, covers the experiences of living with lipedema and is based on five categories; “Captivated by a disintegrating body”, “Face the impairments of a chronic condi-tion”, “Experience social exclusion”, “Need emotional support to go on” and “Mull over an insecure future”. The women felt entrapped within their bodies and experienced social exclusion due to the chronic symptoms and the progressive body shape alteration caused by their illness. Having experienced deficient information on the illness, varying support from other people, and a deteriorating economic situation, the women face an uncertain future.

Conclusions: Symptoms and restrictions caused by lipedema affect women’s livelihood and future, as there are no indications for disease improvement. Preventive work aimed at reducing health deterioration should be a priority. More research is needed to raise health-care awareness regarding difficulties experienced by patients with lipedema.

Place, publisher, year, edition, pages
Taylor & Francis, 2024
Keywords
Lipedema, Women, Qualitative research, Content analysis, Body Image
National Category
Dermatology and Venereal Diseases
Research subject
Dermatology and Venerology
Identifiers
urn:nbn:se:umu:diva-218759 (URN)10.1080/17482631.2023.2300152 (DOI)001133286800001 ()38159285 (PubMedID)2-s2.0-85181414770 (Scopus ID)
Funder
Region Västerbotten
Available from: 2023-12-31 Created: 2023-12-31 Last updated: 2024-08-14Bibliographically approved
Pissa, M., Hashem, R., Shayesteh, A., Wrisley, S. & Micu, E. (2024). Evaluation of quality of life, anxiety, and depression in patients with primary axillary hyperhidrosis undergoing treatment with a microwave device: one-year follow-up. Acta Dermato-Venereologica, 104
Open this publication in new window or tab >>Evaluation of quality of life, anxiety, and depression in patients with primary axillary hyperhidrosis undergoing treatment with a microwave device: one-year follow-up
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2024 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 104Article in journal (Refereed) Published
Abstract [en]

Hyperhidrosis is associated with social and emotional stress, affecting quality of life. Microwave energy technology treats primary axillary hyperhidrosis by thermolysis of sweat glands. The successful reduction of sweating in patients with primary axillary hyperhidrosis after microwave treatment has been studied, but there is limited evidence on the psychological and long-term effects. This study examined patient- reported outcome measures including depression and anxiety in patients with primary axillary hyperhidrosis and the effect of microwave therapy on these parameters. Patients received 1 or 2 microwave-based treatments, within 3-month intervals. All patients were finally examined at approximately 1 year after the first treatment using the Hyperhidrosis Disease Severity Scale, Hyperhidrosis Quality of Life©, Dermatology Life Quality Index, and Hospital Anxiety and Depression Scale©. A total of 103 individuals with primary axillary hyperhidrosis were included in the study, with a Hyperhidrosis Disease Severity Scale score of 3 or 4. Statistically significant improvement in quality of life, anxiety, and depression scores were observed at 1-year follow-up. The primary endpoint, Hyperhidrosis Disease Severity Scale of 2 or less 1 year after the first treatment, was achieved by 88.2% of patients. No serious adverse side effects were observed.

Place, publisher, year, edition, pages
Uppsala: Medical Journals Sweden, 2024
Keywords
axillary, hyperhidrosis, microwave, quality of life, anxiety
National Category
Dermatology and Venereal Diseases
Research subject
Dermatology and Venerology
Identifiers
urn:nbn:se:umu:diva-229239 (URN)10.2340/actadv.v104.40543 (DOI)001314683800005 ()39235052 (PubMedID)2-s2.0-85203322221 (Scopus ID)
Funder
Medical Research Council of Southeast Sweden (FORSS), FORSS-932159, FORSS-969108
Available from: 2024-09-05 Created: 2024-09-05 Last updated: 2025-04-24Bibliographically approved
Shayesteh, A., Boman, J. & Nylander, E. (2024). Impostor phenomenon is a common feature among individuals with primary hyperhidrosis. SAGE Open Medicine, 12, Article ID 20503121231220828.
Open this publication in new window or tab >>Impostor phenomenon is a common feature among individuals with primary hyperhidrosis
2024 (English)In: SAGE Open Medicine, E-ISSN 2050-3121, Vol. 12, article id 20503121231220828Article in journal (Refereed) Published
Abstract [en]

Background: Primary hyperhidrosis consists of excessive focal sweating. Affected individuals camouflage the sweating on their body, avoiding stigmatisation. Hence, misrepresentation in social interactions is a common feature in patients with hyperhidrosis. The aim of this study was to investigate impostor phenomenon, perfectionism, self-compassion, stress and anxiety among individuals with primary hyperhidrosis.

Methods: A cross-sectional study was conducted at our clinic among 100 participants with axillary and palmar primary hyperhidrosis. The questionnaire contained a hyperhidrosis part and Perceived Stress Scale-4, Generalised Anxiety Disorder Scale-2, Clinical Perfectionism Questionnaire-6, Self-Compassion Scale Short form and Clance Impostor Phenomenon Scale. Descriptive statistics was used for analyses of categorical variables. As data were normally distributed independent t-test and one-way analysis of variance with post hoc Tukey test were used to compare the mean values for the questionnaires with other variables. Pearson's correlation was used, and a forward multiple linear regression model was performed to predict presence of impostor phenomenon with gender, age and other scales in this study.

Results: Impostor phenomenon occurred in almost half of our patients (48%) with hyperhidrosis. While feelings of impostor phenomenon were more common in women, there was no difference between gender regarding its intensity levels (p = 0.07). In addition, we found a significant (p < 0.001) negative correlation between impostor phenomenon and self-compassion, while feelings of impostor phenomenon increased with stress, anxiety and perfectionism (p < 0.001).

Conclusions: Feelings of impostor phenomenon was found in 48% of individuals with hyperhidrosis which indicates that it is a common feature in this patient group. Future research is warranted regarding the prevalence of impostor phenomenon in hyperhidrosis and other medical conditions, among men and women, seeking medical healthcare. Psychological interventions in hyperhidrosis may be beneficial both for the individual and in public health, by facilitating management of patients' daily lives and saving considerable resources in healthcare regarding pharmacological interventions and medical consultations.

Place, publisher, year, edition, pages
Sage Publications, 2024
Keywords
Primary hyperhidrosis, impostor phenomenon, perfectionism, self-compassion, questionnaires, Hyperhidros, Impostor fenomen, Stress, Perfektionism, Ångest
National Category
Dermatology and Venereal Diseases
Research subject
Psychology; Dermatology and Venerology
Identifiers
urn:nbn:se:umu:diva-220178 (URN)10.1177/20503121231220828 (DOI)001152422600001 ()38283646 (PubMedID)2-s2.0-85183639679 (Scopus ID)
Available from: 2024-01-29 Created: 2024-01-29 Last updated: 2024-06-25Bibliographically approved
Alsterholm, M., Svedbom, A., Anderson, C. D., Holm Sommar, L., Ivert, L. U., Josefson, A., . . . Johansson, E. K. (2023). Establishment and utility of SwedAD: a nationwide Swedish registry for patients with atopic dermatitis receiving systemic pharmacotherapy. Acta Dermato-Venereologica, 103, Article ID adv7312.
Open this publication in new window or tab >>Establishment and utility of SwedAD: a nationwide Swedish registry for patients with atopic dermatitis receiving systemic pharmacotherapy
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2023 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 103, article id adv7312Article in journal (Refereed) Published
Abstract [en]

SwedAD, a Swedish nationwide registry for patients with atopic dermatitis receiving systemic pharmacotherapy, was launched on 1 September 2019. We describe here the establishment of a user-friendly registry to the benefit of patients with atopic dermatitis. By 5 November 2022, 38 clinics had recorded 931 treatment episodes in 850 patients with an approximate national coverage rate of 40%. Characteristics at enrolment included median Eczema Area and Severity Index (EASI) 10.2 (interquartile range 4.0, 19.4), Patient-Oriented Eczema Measure (POEM) 18.0 (10.0, 24.0), Dermatology Life Quality Index (DLQI) 11.0 (5.0, 19.0) and Peak Itch Numerical Rating Scale-11 (NRS-11) 6.0 (3.0, 8.0). At 3 months, median EASI was 3.2 (1.0, 7.3) and POEM, DLQI, and NRS-11 were improved. Regional coverage varied, reflecting the distribution of dermatologists, the ratio of public to private healthcare, and difficulties in recruiting certain clinics. This study highlights the importance of a nationwide registry when managing systemic pharmacotherapy of atopic dermatitis.

Place, publisher, year, edition, pages
Medical Journals Sweden AB, 2023
Keywords
dupilumab, Janus kinase inhibitors, methotrexate, real-world data, registries
National Category
Dermatology and Venereal Diseases
Research subject
Dermatology and Venerology
Identifiers
urn:nbn:se:umu:diva-206800 (URN)10.2340/actadv.v103.7312 (DOI)000972092100013 ()37021597 (PubMedID)2-s2.0-85151799627 (Scopus ID)
Funder
Swedish Asthma and Allergy AssociationKarolinska Institute
Available from: 2023-04-17 Created: 2023-04-17 Last updated: 2023-09-05Bibliographically approved
Shayesteh, A., Fisher, H., Boman, J. & Nylander, E. (2023). High Risk Sexual Behaviour may be Identified by a Short Version of the Fisher Temperament Inventory. Acta Dermato-Venereologica, 103, adv18469, Article ID adv18469.
Open this publication in new window or tab >>High Risk Sexual Behaviour may be Identified by a Short Version of the Fisher Temperament Inventory
2023 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 103, p. adv18469-, article id adv18469Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Medical Journals Sweden AB, 2023
Keywords
Sexual risk-taking, Fishers Termperament Inventory, Questionnaire
National Category
Dermatology and Venereal Diseases
Research subject
Dermatology and Venerology
Identifiers
urn:nbn:se:umu:diva-218758 (URN)10.2340/actadv.v103.18469 (DOI)38112211 (PubMedID)2-s2.0-85180384974 (Scopus ID)
Funder
Region VästerbottenRegion Västerbotten
Available from: 2023-12-31 Created: 2023-12-31 Last updated: 2024-01-02Bibliographically approved
Shayesteh, A. (2023). Hyperhidros: Byt inte direkt till annat preparat [Letter to the editor]. Läkartidningen
Open this publication in new window or tab >>Hyperhidros: Byt inte direkt till annat preparat
2023 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518Article in journal, Letter (Other (popular science, discussion, etc.)) Published
Place, publisher, year, edition, pages
Stockholm: , 2023
National Category
Dermatology and Venereal Diseases
Research subject
Dermatology and Venerology
Identifiers
urn:nbn:se:umu:diva-216103 (URN)
Note

Publicerad på Lakartidningen.se 2023-01-02

Available from: 2023-11-01 Created: 2023-11-01 Last updated: 2023-11-02Bibliographically approved
Shayesteh, A., Boman, A., Hawas, E. & Carlberg, B. (2023). Reconstituted and frozen botulinum toxin A is as effective and safe as fresh for treating axillary hyperhidrosis: a retrospective study. PLOS ONE, 18(12), Article ID e0295393.
Open this publication in new window or tab >>Reconstituted and frozen botulinum toxin A is as effective and safe as fresh for treating axillary hyperhidrosis: a retrospective study
2023 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 18, no 12, article id e0295393Article in journal (Refereed) Published
Abstract [en]

The use of reconstituted and frozen left-over botulinum toxin A, for treatment of patients with axillary hyperhidrosis seems to be common practice in healthcare. Thus, the objective of this study was to investigate the efficacy and safety of frozen and thawed versus fresh reconstituted abobotulinum toxin (Dysport®) and onabotulinum toxin (Botox®) in the treatment of axillary hyperhidrosis. A retrospective study was conducted analysing efficacy and data from pre- and 24 weeks post-treatment questionnaires together with medical records of individuals with moderate to severe axillary hyperhidrosis. The patients had received fresh prepared botulinum toxin A in their right axilla while frozen and thawed botulinum toxin A had been administered in their left axilla. Treatment was conducted at our Hyperhidrosis Clinic, Umeå University Hospital, Sweden 2019-2021. Pre- and post-treatment questionnaires from 106 patients were analysed. The patients were 18 to 55 years old, with a mean age of 30.7 ± 9.9 years. No significant differences in patient-reported variables, Hyperhidrosis Disease Severity Scale and VAS 10-point scale, were found between the different preparations (frozen compared to fresh) for abobotulinum toxin and onabotulinum toxin, before treatment and at 6 months follow-up. Multivariable regression analysis resulted in no significant difference regarding side-effects between the preparations or brands of botulinum toxin. The findings of this study support our clinical experience that both abobotulinum toxin and onabotulinum toxin, reconstituted, frozen and thawed, seem to be as effective and safe as fresh prepared botulinum toxin when treating axillary hyperhidrosis. Our findings indicate that left-over preparations of abo- and onabotulinum toxins, stored and frozen for up to 6 months, is a cost-and time-effective way of handling botulinum toxin for treatment of axillary hyperhidrosis.

Keywords
Hyperhidros, botulinumtoxin, retrospektiv studie, klinisk effect
National Category
Dermatology and Venereal Diseases
Research subject
Dermatology and Venerology; drug formulation and drug delivery
Identifiers
urn:nbn:se:umu:diva-217954 (URN)10.1371/journal.pone.0295393 (DOI)001123190300005 ()38048338 (PubMedID)2-s2.0-85178569557 (Scopus ID)
Available from: 2023-12-13 Created: 2023-12-13 Last updated: 2025-04-24Bibliographically approved
Rosendahl, K., Shayesteh, A. & Nylander, E. (2022). Characteristics of women seeking care at a vulvar clinic: a study of 600 patients during a 17‐year period. JEADV Clinical Practice, 2(1), 73-79
Open this publication in new window or tab >>Characteristics of women seeking care at a vulvar clinic: a study of 600 patients during a 17‐year period
2022 (English)In: JEADV Clinical Practice, ISSN 2768-6566, Vol. 2, no 1, p. 73-79Article in journal (Refereed) Published
Abstract [en]

Background: Symptoms from the vulva and vagina affect about one-third of all women and have a negative influence both on sexual health and psychosocial well-being. Research regarding vulvar diseases is sparse and there is a need for a better understanding of women seeking care for vulvar diseases.

Objectives: The objectives of this descriptive study were to investigate symptoms, signs, and background characteristics of women attending our multidisciplinary vulvar clinic at the University Hospital, Umeå, Sweden between 2005 and 2021.

Methods: We conducted a prospective study by using a vulvar-specific questionnaire and reviewed the medical records to collect supplementary data.

Results: A total of 600 women participated. The most common symptom among all participants was dyspareunia (67.6%). Pain diagnoses dominated in the younger population while inflammatory diseases were most common among patients 40 years of age or more. We found a significant association between dyspareunia and negative experiences of gynaecological examination (p < 0.001) as well as between pruritus and not having a regular contact with a psychologist (p < 0.05).

Conclusions: Women seeking care at our vulvar clinic exhibit a complicated and complex set of symptoms intertwined with many aspects of life. Increasing awareness among healthcare professionals, an experienced team at the clinic, and a multidisciplinary approach regarding the symptoms and needs of women with vulvar conditions are important to optimise care and treatment. Clinicians must be aware that vulvar diseases may have different symptomatology due to age. It is also important to highlight that the symptomatology presented by patients attending for vulvar diseases, has changed during the past decade.

Place, publisher, year, edition, pages
John Wiley & Sons, 2022
Keywords
dyspareunia, inflammatory diseases, multidisciplinary, pain, vulvar diseases
National Category
Dermatology and Venereal Diseases
Research subject
Dermatology and Venerology
Identifiers
urn:nbn:se:umu:diva-216101 (URN)10.1002/jvc2.76 (DOI)001332699200003 ()2-s2.0-85181448311 (Scopus ID)
Funder
Region Västerbotten
Available from: 2023-11-01 Created: 2023-11-01 Last updated: 2025-04-24Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-0700-7195

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