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Andersson, Christer
Publications (10 of 29) Show all publications
Granlund, L., Norberg, M., Ramnemark, A., Andersson, C., Lindkvist, M. & Fhärm, E. (2018). Vitamin D is associated with lower limb muscle strength and grip strength in Middle Eastern- and African-born immigrants in Sweden. Nutrition Research, 59, 29-35
Open this publication in new window or tab >>Vitamin D is associated with lower limb muscle strength and grip strength in Middle Eastern- and African-born immigrants in Sweden
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2018 (English)In: Nutrition Research, ISSN 0271-5317, E-ISSN 1879-0739, Vol. 59, p. 29-35Article in journal (Refereed) Published
Abstract [en]

There is increasing evidence that vitamin D status is associated with muscle function. Vitamin D deficiency is common in immigrants. We hypothesized that there was a positive association between vitamin D status and muscle strength in immigrants. The aim of this study was to examine associations between vitamin D status and muscle strength in an immigrant population in Sweden. All immigrants aged 25-65 years, born in 9 African or Middle East countries, and living in a district in Umeå (n = 1306) were invited. A total of 111 men and 105 women (16.5%) completed the study. Lower limb muscle strength was examined using a standardized muscle function indices of muscle strength. Grip strength was examined using a JAMAR hand dynamometer. Serum 25-hydroxyvitamin D [25(OH)D] was measured using liquid chromatography–tandem mass spectrometry. The analyses were adjusted for sex, age, height, body mass index, years since immigration, 25(OH)D, vitamin D deficiency, physical activity, and medical and socioeconomic factors. Twelve percent of the immigrants had vitamin D deficiency [25(OH)D levels <25 nmol/L]. In multivariable analyses, reduced lower limb muscle strength remained linearly associated with lower 25(OH)D concentrations (P = .008) and weaker grip strength remained associated with vitamin D deficiency (P = .022) after adjustments. The association between vitamin D deficiency and reduced lower limb muscle strength did not reach statistical significance (P = .052). The results demonstrate that vitamin D deficiency and low 25(OH)D concentrations were associated with muscle weakness in immigrants.

Place, publisher, year, edition, pages
Elsevier, 2018
National Category
General Practice
Research subject
Family Medicine
Identifiers
urn:nbn:se:umu:diva-147571 (URN)10.1016/j.nutres.2018.07.009 (DOI)000451792500003 ()30442230 (PubMedID)
Note

First published in thesis in manuscript form.

Available from: 2018-05-08 Created: 2018-05-08 Last updated: 2018-12-19Bibliographically approved
Granlund, L., Ramnemark, A., Andersson, C., Lindkvist, M., Fhärm, E. & Norberg, M. (2016). Prevalence of vitamin D deficiency and its association with nutrition, travelling and clothing habits in an immigrant population in Northern Sweden. European Journal of Clinical Nutrition, 70(3), 373-379
Open this publication in new window or tab >>Prevalence of vitamin D deficiency and its association with nutrition, travelling and clothing habits in an immigrant population in Northern Sweden
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2016 (English)In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 70, no 3, p. 373-379Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To study prevalence and determinants of vitamin D deficiency in immigrants from Africa and the Middle East living in Umeå, Sweden.

DESIGN: Cross-sectional population based.

SETTING: Umeå, Sweden (63° N).

SUBJECTS/METHODS: Immigrants aged 25-65 years from nine countries in Africa or the Middle East (n=1306) were invited. A total of 111 men and 106 women (16.5%) completed the study. S-25-hydroxyvitamin D3 was measured with HPLC. Anthropometry, medical, socioeconomic and lifestyle data were registered.

RESULTS: Vitamin D status was insufficient or deficient in 73% of the participants. Specifically, 12% had vitamin D deficiency (25(OH)D3<25 nmol/l), and only 3.7% had optimal vitamin D status (25(OH)D3 75-125 nmol/l). Mean 25(OH)D3 level was 41.0 nmol/l (±16.6) with no difference between sexes. Levels of 25(OH)D3 were lower (P=0.030) and vitamin D deficiency was twice as common in immigrants from Africa compared with those from the Middle East. In the multiple regression analysis, vitamin D deficiency was significantly associated with low fatty fish intake (OR 4.31, 95% CI 1.61-11.55), not travelling abroad (OR 3.76, 95% CI 1.18-11.96) and wearing long-sleeved clothes in summer (OR 3.15, 95% CI 1.09-9.12).

CONCLUSIONS: The majority of immigrants from Africa and the Middle East who live in northern Sweden have vitamin D deficiency or insufficiency. Our results are consistent with sun exposure and a diet with high intake of fatty fish being most important in avoiding vitamin D deficiency.

National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-112102 (URN)10.1038/ejcn.2015.176 (DOI)000371667700014 ()26508457 (PubMedID)
Available from: 2015-12-02 Created: 2015-12-02 Last updated: 2018-06-07Bibliographically approved
Innala, E., Bäckström, T., Sundström Poromaa, I., Andersson, C. & Bixo, M. (2012). Women with acute intermittent porphyria have a defect in 5 alpha-steroid production during the menstrual cycle. Acta Obstetricia et Gynecologica Scandinavica, 91(12), 1445-1452
Open this publication in new window or tab >>Women with acute intermittent porphyria have a defect in 5 alpha-steroid production during the menstrual cycle
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2012 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 91, no 12, p. 1445-1452Article in journal (Refereed) Published
Abstract [en]

Objective. To measure serum concentrations of progesterone, estradiol and 5 alpha- and 5 beta-reduced progesterone metabolites in the follicular and luteal phases of the menstrual cycle in women with latent acute intermittent porphyria and manifest acute intermittent porphyria in comparison with healthy control women. Design. A descriptive study with repeated measurements during a complete, ovulatory menstrual cycle. Setting. University hospital out-patient clinic. Population. Thirty-two women with DNA-diagnosed acute intermittent porphyria and 20 healthy control women. Methods. Blood samples for serum progesterone, estradiol, allopregnanolone and pregnanolone were drawn on predefined menstrual cycle days, twice in the follicular phase and three times in the luteal phase. Serum levels of estradiol and progesterone were analysed with commercial kits. Allopregnanolone and pregnanolone levels were analysed with radioimmunoassay following diethylether extraction and celite column chromatography. Main outcome measures. Changes in serum levels of progesterone, estradiol, allopregnanolone and pregnanolone throughout the menstrual cycle. Results. Women with acute intermittent porphyria displayed lower serum concentrations of allopregnanolone in comparison with healthy control women, the difference being most prominent in the luteal phase (p < 0.001). Levels of pregnanolone did not differ significantly between groups. No significant difference was found between women with latent acute intermittent porphyria and manifest acute intermittent porphyria. Conclusions. Decreased levels of the 5 alpha-reduced progesterone metabolite allopregnanolone were found in the menstrual cycle of women with acute intermittent porphyria. This has not been reported previously and could indicate a reduced 5 alpha-reductase type 1 capacity in the ovary and liver among these women.

Place, publisher, year, edition, pages
John Wiley & Sons, 2012
Keywords
Acute intermittent porphyria, menstrual cycle, progesterone, allopregnanolone, pregnanolone
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:umu:diva-63761 (URN)10.1111/j.1600-0412.2012.01536.x (DOI)000312032700015 ()
Available from: 2013-01-14 Created: 2013-01-07 Last updated: 2018-06-08Bibliographically approved
Innala, E. & Andersson, C. (2011). Reply to letter to the editor from prof Viroj Wiwanitkit, Bankok, Thailand. Journal of Internal Medicine, 270(4), 397-397
Open this publication in new window or tab >>Reply to letter to the editor from prof Viroj Wiwanitkit, Bankok, Thailand
2011 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 270, no 4, p. 397-397Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Oxford: Blackwell Scientific Publications, 2011
National Category
Basic Medicine
Identifiers
urn:nbn:se:umu:diva-48287 (URN)10.1111/j.1365-2796.2011.02421.x (DOI)000295096600013 ()
Available from: 2011-10-17 Created: 2011-10-14 Last updated: 2018-06-08Bibliographically approved
Innala, E. & Andersson, C. (2011). Screening for hepatocelular carcinoma in acute intermittent porphyria: A 15-year follow-up in northern Sweden. Journal of Internal Medicine, 269(5), 538-545
Open this publication in new window or tab >>Screening for hepatocelular carcinoma in acute intermittent porphyria: A 15-year follow-up in northern Sweden
2011 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 269, no 5, p. 538-545Article in journal (Other academic) Published
Abstract [en]

Objectives: To evaluate the benefit of screening for hepatocellular carcinoma (HCC) in gene carriers of acute intermittent porphyria (AIP) and estimate the annual incidence of HCC in this group.

Subjects: All AIP gene carriers aged ≥55 years from the northernmost county in Sweden, Norrbotten, were invited for screening in this prospective study every 1–1.5 years during the period 1994–2009. We registered all HCC cases amongst AIP gene carriers in the northern region of Sweden (four counties). We compared gene carriers with repeated screening intervals of <2 years (Group A) with controls (Group B; i.e. gene carriers who had never been screened, those screened for the first time or screened at intervals of >2 years, or dropouts). The screening included radiological examination of the liver and relevant laboratory tests.

Results, A total of 62 AIP subjects participated in the study, comprising 33% of the total AIP population aged >55 years in the northern region of Sweden. HCC was diagnosed in 22 AIP subjects (12 men and 10 women), mean age 69 (59–82) years. Amongst these subjects, 73% had experienced prior AIP attacks. The incidence rate ratio for HCC was 64 (52 in men and 93 in women). There were no cases of hepatitis B/C or alcohol abuse. Liver cirrhosis was rare. Liver resection could be performed in most subjects in Group A. Fourteen patients died of HCC, one in Group A and 13 in Group B. Compared with those who were not screened regularly, screening was associated with improved 3-year and 5-year survival (P = 0.005 and 0.038).

Conclusions, Screening for HCC in carriers of AIP enables early diagnosis and a choice of potentially curative treatments with improved prognosis. We recommend annual screening using liver imaging for AIP gene carriers >50 years of age.

Place, publisher, year, edition, pages
Wiley, 2011
Keywords
acute intermittent porphyria, hepatocellular carcinoma, screening, surveillance
National Category
General Practice
Research subject
Medicine
Identifiers
urn:nbn:se:umu:diva-36817 (URN)10.1111/j.1365-2796.2010.02335.x (DOI)
Available from: 2010-10-12 Created: 2010-10-12 Last updated: 2018-06-08Bibliographically approved
Wahlin, S., Harper, P., Sardh, E., Andersson, C., Andersson, D. E. & Ericzon, B.-G. (2010). Combined liver and kidney transplantation in acute intermittent porphyria. Transplant International, 23(6), e18-e21
Open this publication in new window or tab >>Combined liver and kidney transplantation in acute intermittent porphyria
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2010 (English)In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 23, no 6, p. e18-e21Article in journal (Refereed) Published
Abstract [en]

We report two patients with acute intermittent porphyria (AIP) who were successfully treated with combined liver and kidney transplantation. Both had a very poor quality of life as a result of years of frequent acute porphyria symptoms, chronic peripheral neuropathy and renal failure requiring dialysis. After transplantation, clinical and biochemical signs of porphyria disappeared. The excretion pattern of porphyrin precursors normalized within the first day and plasma porphyrins returned to normal within a week. These and other recent cases have clarified previous concerns and have helped to formulate the indications for and the timing of transplantation in AIP.

Keywords
acute intermittent porphyria;combined liver–kidney transplantation;dialysis;kidney transplantation;liver transplantation;porphobilinogen deaminase
National Category
Urology and Nephrology
Identifiers
urn:nbn:se:umu:diva-41292 (URN)10.1111/j.1432-2277.2009.01035.x (DOI)
Available from: 2011-03-22 Created: 2011-03-22 Last updated: 2018-06-08Bibliographically approved
Innala, E., Bäckström, T., Bixo, M. & Andersson, C. (2010). Evaluation of gonadotropin-releasing hormone agonist treatment for prevention of menstrual-related attacks in acute porphyria. Acta Obstetricia et Gynecologica Scandinavica, 89(1), 95-100
Open this publication in new window or tab >>Evaluation of gonadotropin-releasing hormone agonist treatment for prevention of menstrual-related attacks in acute porphyria
2010 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 89, no 1, p. 95-100Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To describe the benefits and adverse effects of gonadotropin-releasing hormone (GnRH) agonist treatment for prevention of recurrent menstrual attacks in women with acute intermittent porphyria and variegate porphyria. To describe concomitant add-back therapies with estradiol and progesterone and describe their benefits and adverse effects. DESIGN: A retrospective follow-up with questionnaires, interviews and medical records. SETTING: Out-patient care at the Umeå University Hospital in Sweden. POPULATION: Sixteen Caucasian women with DNA-diagnosed porphyria and menstrual-cycle-related porphyria attacks were treated with GnRH agonists during 1984-2000. Fourteen women participated. The mean age when treatment started was 33 years (17-48 years). The duration of treatment varied between 5 months and 9 years. METHODS: GnRH agonists were administered by the intranasal route or by injections. To reduce menopausal symptoms, add-back therapy with low doses of estradiol was administered, and for endometrial protection progesterone was usually administered. MAIN OUTCOME MEASURES: Treatment effects and adverse events as detected in questionnaires, interviews and medical records. RESULTS: Eleven women reported benefits from GnRH agonist treatment with less intense and/or less frequent porphyria attacks, and in four of them attacks almost disappeared. Two women reported no change. One woman had only temporary improvement. Porphyria attacks were triggered by solely estradiol add-back in two women and in five of nine women when progesterone was given. CONCLUSIONS: GnRH agonist treatment can ameliorate menstrual-cycle-related attacks of porphyria. Dose findings for GnRH agonists and add-back regimes especially for progesterone are intricate.

Keywords
Porphyria, menstrual, GnRH agonist therapy, add-back
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Obstetrics and Gynaecology
Identifiers
urn:nbn:se:umu:diva-36810 (URN)10.3109/00016340903390729 (DOI)000275251200016 ()20021268 (PubMedID)
Available from: 2010-10-12 Created: 2010-10-12 Last updated: 2018-06-08Bibliographically approved
Bylesjö, I., Wikberg, A. & Andersson, C. (2009). Clinical aspects of acute intermittent porphyria in northern Sweden: A population-based study.. Scandinavian Journal of Clinical and Laboratory Investigation, 69(5), 612-618
Open this publication in new window or tab >>Clinical aspects of acute intermittent porphyria in northern Sweden: A population-based study.
2009 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 69, no 5, p. 612-618Article in journal (Refereed) Published
Abstract [en]

The objective of this study was to update the clinical issues of acute intermittent porphyria (AIP), as they have not been in focus for years, and to be aware of potentially associated disorders and social consequences. A total of 356 gene carriers of AIP from northern Sweden participated in this retrospective population-based study. Eight mutations were found with a predominance of W198X (89%). Clinical manifestations of AIP (manifest AIP) were identified in 42%, 65% were women. Women were more severely stricken by AIP attacks concerning number and duration, hospital admission and early onset. Men reporting most attacks were > 40 years of age. In addition to traditional symptoms during attacks, fatigue was commonly described. Chronic AIP symptoms and disability pension due to AIP were reported in about 20% of subjects. Precipitating factors were reported with evident sex differences. Half of the gene carriers who were on medications used drugs considered not safe (in 1999), mainly antihypertensive drugs. Smoking was associated with high AIP attack frequency. Elevated levels of ALT, bile acids, creatinine, U-ALA and U-PBG and decreased levels of creatinine clearance were associated with manifest AIP. The same was true for hypertension and myalgia in the legs. Hepatoma was strikingly overrepresented. The high prevalence of manifest AIP in this study could be explained by a mutation-dependent penetrance. Our results emphasize the importance of early diagnosis, counselling and treatment of attacks, screening and treatment of associated disorders.

Place, publisher, year, edition, pages
Informa Healthcare, 2009
Keywords
Acute intermittent porphyria, precipitating factor, signs and symptoms, associated disease, prognosis
Identifiers
urn:nbn:se:umu:diva-36249 (URN)10.1080/00365510902935979 (DOI)
Available from: 2010-09-23 Created: 2010-09-23 Last updated: 2018-06-08Bibliographically approved
Norberg, M., Stenlund, H., Lindahl, B., Andersson, C., Weinehall, L., Hallmans, G. & Eriksson, J. (2007). Components of metabolic syndrome predicting diabetes: no role of inflammation or dyslipidemia.. Obesity (Silver Spring), 15(7), 1875-1885
Open this publication in new window or tab >>Components of metabolic syndrome predicting diabetes: no role of inflammation or dyslipidemia.
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2007 (English)In: Obesity (Silver Spring), ISSN 1930-7381, Vol. 15, no 7, p. 1875-1885Article in journal (Refereed) Published
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-16214 (URN)10.1038/oby.2007.222 (DOI)17636107 (PubMedID)
Available from: 2007-11-30 Created: 2007-11-30 Last updated: 2018-06-09Bibliographically approved
Norberg, M., Stenlund, H., Lindahl, B., Andersson, C., Eriksson, J. & Weinehall, L. (2007). Work stress and low emotional support is associated with increased risk of future type 2 diabetes in women. Diabetes Research and Clinical Practice, 76(3), 368-377
Open this publication in new window or tab >>Work stress and low emotional support is associated with increased risk of future type 2 diabetes in women
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2007 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 76, no 3, p. 368-377Article in journal (Refereed) Published
Abstract [en]

A case-referent study nested within a population-based health survey investigated the associations between psychosocial stress, such as work stress and low emotional support, and future development of type 2 diabetes among occupationally working middle-aged men and women. All participants in a health survey conducted during 1989-2000 (n=33,336) in Umeå in northern Sweden, were included. We identified 191 cases, who were not diabetic initially but were diagnosed with type 2 diabetes after 5.4+/-2.6 years. Two age- and sex-matched referents were selected for each case. Multivariate logistic regression analyses and interaction effects between variables were evaluated.

In women, passive or tense working situations were associated with future type 2 diabetes with odds ratios 3.6 (95% confidence interval 1.1-11.7) and 3.6 (1.0-13.3), respectively, and also low emotional support 3.0 (1.3-7.0). These associations were not seen in men. In women, they remained after adjustment for BMI, civil status and educational level, and there were also tendencies for interactions between work stress and low emotional support.

In conclusion, work stress and low emotional support may increase the risk of type 2 diabetes in women, but not in men. These findings contribute to our understanding of psychosocial stress as potential risk factors for type 2 diabetes in a Swedish population.

National Category
General Practice
Identifiers
urn:nbn:se:umu:diva-14584 (URN)10.1016/j.diabres.2006.09.002 (DOI)17034894 (PubMedID)
Available from: 2007-09-12 Created: 2007-09-12 Last updated: 2018-06-09Bibliographically approved
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