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Sjöberg, Rickard L.ORCID iD iconorcid.org/rlsjoberg
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Publications (10 of 95) Show all publications
Tabatabaei Shafiei, P., Åkerstedt, J., Awad, A., Sjöberg, R. L. & Wänman, J. (2025). A prospective study of the association between pain and catastrophizing after selective nerve root blockade. Pain Practice, 25(3), Article ID e70017.
Open this publication in new window or tab >>A prospective study of the association between pain and catastrophizing after selective nerve root blockade
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2025 (English)In: Pain Practice, ISSN 1530-7085, E-ISSN 1533-2500, Vol. 25, no 3, article id e70017Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Pain, comprising sensory and emotional elements, is influenced by pain catastrophizing, which magnifies pain and promotes helplessness and rumination. This study explores the relationship between pain catastrophizing and outcomes following selective nerve root blockade (SNRB) in patients with lumbar radicular pain (LRP).

METHODS: A prospective cohort study of 103 LRP patients, confirmed by MRI, was conducted. All participants underwent SNRB at Umeå University Hospital. Outcomes were measured using PROMIS-29 and the Pain Catastrophizing Scale (PCS) at baseline and several intervals up to 84 days post-intervention. Patients were categorized into responder (≥30% pain reduction) and non-responder groups and stratified into three groups based on baseline PCS scores. Changes in outcomes from baseline to 14 days post-SNRB were analyzed in relation to PCS groups. PCS changes over time were evaluated between responders and non-responders. Statistical analyses assessed PCS and outcome changes.

RESULTS: Baseline pain catastrophizing was not a significant predictor of pain response to SNRB. However, responders demonstrated significant reductions in pain catastrophizing following the intervention, suggesting that SNRB may influence cognitive coping mechanisms related to pain.

CONCLUSION: SNRB reduces pain catastrophizing in LRP patients, although baseline catastrophizing does not predict pain outcomes. Addressing catastrophizing remains important but may serve better as an outcome measure rather than a predictor of treatment response.

Place, publisher, year, edition, pages
John Wiley & Sons, 2025
Keywords
anesthesia, back pain with radiation, infiltration, nerve block
National Category
Anesthesiology and Intensive Care Surgery
Research subject
Surgery
Identifiers
urn:nbn:se:umu:diva-236107 (URN)10.1111/papr.70017 (DOI)001437020900001 ()40035355 (PubMedID)2-s2.0-86000044997 (Scopus ID)
Available from: 2025-03-05 Created: 2025-03-05 Last updated: 2025-04-10Bibliographically approved
Axelsson, J., Björkblom, B., Asklund, T., Brandel, J., Larhed, S., Ringmar, G. M., . . . Sandström, M. (2025). Characterizing long- and short-survival glioblastoma patients with FLT-PET/MRI and metabolomics. Neuro-Oncology Advances, 7(1), Article ID vdaf034.
Open this publication in new window or tab >>Characterizing long- and short-survival glioblastoma patients with FLT-PET/MRI and metabolomics
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2025 (English)In: Neuro-Oncology Advances, E-ISSN 2632-2498, Vol. 7, no 1, article id vdaf034Article in journal (Refereed) Published
Abstract [en]

Background: Glioblastoma is the most aggressive and malignant brain tumor, characterized by a high degree of heterogeneity, invasiveness, and resistance to treatment. Patients with glioblastoma have a very poor prognosis despite multimodal interventions. In this study, we investigated how 18F-fluorothymidine (18F-FLT) PET combined with contrast-enhanced MRI and blood metabolomics can contribute to evaluate prognosis and treatment response for patients with glioblastoma.

Methods: Patients, scheduled for surgery due to suspected high-grade glioma were included in this clinical study and underwent four 18F-FLT-PET/MRI examinations prior to surgery and during standard treatment. Blood samples were collected and analyzed by metabolomics. Patients were grouped according to survival as long-time survivors (>3 years) and short-time survivors (<500 days).

Results: Both 2 and 6 weeks into treatment, short-time survivors displayed a significantly larger tumor volume than long-time survivors. When comparing MRI findings during treatment, long-time survivors displayed a substantial tumor decrease, whereas the short-time survivors showed minor or no effect. Regarding 18F-FLT-PET the results were not as unambiguous. Furthermore, there was a clear and significant separation in the metabolomic pattern in blood between the survival groups and across treatment time points.

Conclusions: MRI measures of tumor volume and growth during treatment appear to be prognostic clinical factors that affect outcome. Metabolomic patterns in blood differ significantly between the defined survival groups and may serve as support for an early forecast of prognosis. We also observe a clear separation in metabolite levels between different time points during treatment, which likely reflects treatment effects.

Place, publisher, year, edition, pages
Oxford University Press, 2025
Keywords
glioblastoma, metabolomics, prognosis, PET
National Category
Neurosciences
Research subject
Oncology
Identifiers
urn:nbn:se:umu:diva-238396 (URN)10.1093/noajnl/vdaf034 (DOI)2-s2.0-105004202543 (Scopus ID)
Funder
Sjöberg Foundation, 2020-01-07-08Swedish Cancer Society, CAN 2013/701Cancerforskningsfonden i Norrland, LP 18-2185Cancerforskningsfonden i Norrland, LP 20-2249
Available from: 2025-05-05 Created: 2025-05-05 Last updated: 2025-05-23Bibliographically approved
Sjöberg, R. L. (2025). [Förträngda minnen] Ett korthus som börjat rasa ...eller?. Seniora läkare (1), 12-15
Open this publication in new window or tab >>[Förträngda minnen] Ett korthus som börjat rasa ...eller?
2025 (Swedish)In: Seniora läkare, ISSN 2002-0538, no 1, p. 12-15Article in journal (Other (popular science, discussion, etc.)) Published
Place, publisher, year, edition, pages
Stockholm: Seniora läkare, 2025
National Category
Applied Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:umu:diva-238492 (URN)
Available from: 2025-05-06 Created: 2025-05-06 Last updated: 2025-05-06Bibliographically approved
Malmberg, C., Numan Hellquist, B., Sadanandan, S. A., Sandström, M., Wu, W.-Y. Y., Björkblom, B., . . . Sjöberg, R. L. (2024). Antidepressant drugs and risk of developing glioma: a national registry-based case control study and a meta-analysis. American Journal of Epidemiology, 193(11), 1592-1599
Open this publication in new window or tab >>Antidepressant drugs and risk of developing glioma: a national registry-based case control study and a meta-analysis
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2024 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 193, no 11, p. 1592-1599Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to investigate if use of antidepressants is related to the risk of developing lower (WHO grade 2-3) and higher grade (WHO grade 4) glioma. A registry based case-control study was performed using 1283 glioma cases and 6400 age-, sex- and geographically matched controls, diagnosed in Sweden 2009-2013. Conditional logistic regression was used to analyze whether Selective Serotonin Reuptake Inhibitors (SSRIs) or non-SSRIs were associated with the risk of developing lower- or higher-grade glioma in the study population. Our results show that use of antidepressant medication was not associated with the risk of developing glioma. We also performed a meta-analysis in which the dataset from the present study was combined with results from two previous epidemiological studies to answer the same questions. The meta-analysis showed a modest risk reduction of developing glioma in relation to antidepressant treatment (OR 0.90 [95% CI 0.83-0.97]), when all glioma subgroups and all forms of antidepressant medications were combined. In conclusion, it remains possible that antidepressants may have common monoaminergic mechanism(s) that reduce the risk of developing glioma.

Place, publisher, year, edition, pages
Oxford University Press, 2024
Keywords
Antidepressants, tricyclic antidepressant, selective serotonin reuptake inhibitor, glioma, incidence, risk, brain cancer
National Category
Neurosciences Cancer and Oncology
Research subject
Neurosurgery; Oncology
Identifiers
urn:nbn:se:umu:diva-225383 (URN)10.1093/aje/kwae100 (DOI)001319156400001 ()38825331 (PubMedID)2-s2.0-85208687943 (Scopus ID)
Funder
Swedish Research CouncilSwedish Cancer Society
Available from: 2024-05-30 Created: 2024-05-30 Last updated: 2024-11-19Bibliographically approved
Edström, S., Numan Hellquist, B., Sandström, M., Sadanandan, S. A., Björkblom, B., Melin, B. & Sjöberg, R. L. (2024). Antidepressants and survival in glioma: a registry-based retrospective cohort study. Neuro-Oncology Practice, 11(2), 125-131
Open this publication in new window or tab >>Antidepressants and survival in glioma: a registry-based retrospective cohort study
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2024 (English)In: Neuro-Oncology Practice, ISSN 2054-2577, E-ISSN 2054-2585, Vol. 11, no 2, p. 125-131Article in journal (Refereed) Published
Abstract [en]

Background: Depression and treatment with antidepressant medication is common in patients with malignant glioma. However, the extent to which antidepressants may affect the disease is not fully understood. Therefore, the purpose of the present study was to investigate possible associations between treatment with antidepressant medication and survival in glioma patients.

Methods: We performed a registry-based cohort study including 1231 patients with malignant glioma (WHO grade 2, 3 and 4) having undergone surgery, and 6400 matched controls without glioma. All data was extracted from the RISK North database, which contains information from multiple national population-based registries in Sweden.

Results: Treatment with antidepressants is more common in patients with malignant glioma (27%), compared to controls (16%), p<.001. Treatment with antidepressants after surgery for glioma was significantly associated with poorer survival. These effects were observed both for selective serotonin reuptake inhibitors (SSRIs) and non-SSRIs. In grade 4 glioma, SSRI treatment was associated with a HR of 3.32 (95% CI 2.69–4.10, p<.001), and non-SSRI treatment a HR of 3.54 (95% CI 2.52–4.99, p<.001), compared to glioma patients without antidepressants. In grade 2-3 glioma, the HR for SSRI treatment was 3.26 (95% CI 2.19–4.85, p<.001), and for non-SSRI treatment 7.71 (95% CI 4.22-14.12, p<.001).

Conclusions: Our results demonstrate a negative association between antidepressant medication and survival in glioma. Further research will be needed to clarify causation.

Place, publisher, year, edition, pages
Oxford University Press, 2024
National Category
Neurosciences
Research subject
Neurosurgery
Identifiers
urn:nbn:se:umu:diva-213864 (URN)10.1093/nop/npad057 (DOI)001068482000001 ()38496917 (PubMedID)2-s2.0-85187989046 (Scopus ID)
Funder
Cancerforskningsfonden i NorrlandSwedish Research CouncilSwedish Cancer SocietyRegion Västerbotten
Note

First published online: 30 August 2023

Available from: 2023-08-30 Created: 2023-08-30 Last updated: 2024-04-15Bibliographically approved
Löding, S., Antti, H., Sjöberg, R. L., Melin, B. S. & Björkblom, B. (2024). Blood based metabolic markers of glioma from pre-diagnosis to surgery. Scientific Reports, 14, Article ID 20680.
Open this publication in new window or tab >>Blood based metabolic markers of glioma from pre-diagnosis to surgery
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2024 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 14, article id 20680Article in journal (Refereed) Published
Abstract [en]

Gliomas are highly complex and metabolically active brain tumors associated with poor prognosis. Recent reports have found altered levels of blood metabolites during early tumor development, suggesting that tumor development could be detected several years before clinical manifestation. In this study, we performed metabolite analyses of blood samples collected from healthy controls and future glioma patients, up to eight years before glioma diagnosis, and on the day of glioma surgery. We discovered that metabolites related to early glioma development were associated with an increased energy turnover, as highlighted by elevated levels of TCA-related metabolites such as fumarate, malate, lactate and pyruvate in pre-diagnostic cases. We also found that metabolites related to glioma progression at surgery were primarily high levels of amino acids and metabolites of amino acid catabolism, with elevated levels of 11 amino acids and two branched-chain alpha-ketoacids, ketoleucine and ketoisoleucine. High amino acid turnover in glioma tumor tissue is currently utilized for PET imaging, diagnosis and delineation of tumor margins. By examining blood-based metabolic progression patterns towards disease onset, we demonstrate that this high amino acid turnover is also detectable in a simple blood sample. These findings provide additional insight of metabolic alterations during glioma development and progression.

Place, publisher, year, edition, pages
Springer Nature, 2024
Keywords
Glioma, Glioblastoma, Blood metabolites, Early detection, Surgery, Liquid biopsy
National Category
Biochemistry Molecular Biology
Identifiers
urn:nbn:se:umu:diva-229233 (URN)10.1038/s41598-024-71375-6 (DOI)001457725800044 ()39237693 (PubMedID)2-s2.0-85203420003 (Scopus ID)
Funder
Swedish Cancer Society, 19 0370PJSwedish Cancer Society, 22 31PJ01HSwedish Cancer Society, 21 1384Pj01HCancerforskningsfonden i Norrland, AMP 18-907Cancerforskningsfonden i Norrland, AMP 21-1045Cancerforskningsfonden i Norrland, AMP 22-1084Cancerforskningsfonden i Norrland, AMP 23-1131Lions Cancerforskningsfond i Norr, LP21-2259Swedish Research Council, 2019-01566Sjöberg Foundation, 2020-01-07-08Familjen Erling-Perssons Stiftelse, 2021 0046
Available from: 2024-09-05 Created: 2024-09-05 Last updated: 2025-04-24Bibliographically approved
Stålnacke, M., Eriksson, J., Salami, A., Andersson, M., Nyberg, L. & Sjöberg, R. L. (2024). Functional connectivity of the sensorimotor network before and after surgery in the supplementary motor area. Neuropsychologia, 204, Article ID 109004.
Open this publication in new window or tab >>Functional connectivity of the sensorimotor network before and after surgery in the supplementary motor area
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2024 (English)In: Neuropsychologia, ISSN 0028-3932, E-ISSN 1873-3514, Vol. 204, article id 109004Article in journal (Refereed) Published
Abstract [en]

After resective glioma surgery in the Supplementary Motor Area (SMA), patients often experience a transient disturbance of the ability to initiate speech and voluntary motor actions, known as the SMA syndrome (SMAS). It has been proposed that enhanced interhemispheric functional connectivity (FC) within the sensorimotor system may serve as a potential mechanism for recovery, enabling the non-resected SMA to assume the function of the resected region. The purpose of the present study was to investigate the extent to which changes in FC can be observed in patients after resolution of the SMAS.

Eight patients underwent resection of left SMA due to suspected gliomas, resulting in various levels of the SMA syndrome. Resting-state functional MR images were acquired prior to the surgery and after resolution of the syndrome.

At the group level we found an increased connectivity between the unaffected (right) SMA and the primary motor cortex on the same side following surgery. However, no significant increase in interhemispheric connectivity was observed.

These findings challenge the prevailing notion that increased interhemispheric FC serves as the only mechanism underlying recovery from SMA syndrome and suggest the presence of one or more alternative mechanisms.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
Glioma, Supplementary motor area, SMA, Interhemispheric connectivity, Functional imaging
National Category
Neurosciences
Research subject
Neurosurgery
Identifiers
urn:nbn:se:umu:diva-206849 (URN)10.1016/j.neuropsychologia.2024.109004 (DOI)001325130500001 ()39299453 (PubMedID)2-s2.0-85204550323 (Scopus ID)
Funder
Region VästerbottenSjöberg FoundationCancerforskningsfonden i Norrland
Available from: 2023-04-18 Created: 2023-04-18 Last updated: 2024-10-14Bibliographically approved
Sjöberg, R. L. (2024). Hjärnan och jaget: operationsberättelser från platsen mellan kropp och själ. Norstedts Förlag
Open this publication in new window or tab >>Hjärnan och jaget: operationsberättelser från platsen mellan kropp och själ
2024 (Swedish)Book (Other (popular science, discussion, etc.))
Place, publisher, year, edition, pages
Norstedts Förlag, 2024. p. 218
National Category
Neurosciences
Research subject
Neurosurgery
Identifiers
urn:nbn:se:umu:diva-225387 (URN)9789113133799 (ISBN)
Available from: 2024-05-30 Created: 2024-05-30 Last updated: 2024-09-30Bibliographically approved
Sjöberg, R. L. (2024). I huvudet på en neurokirurg. Modern Psykologi (5), 18-28
Open this publication in new window or tab >>I huvudet på en neurokirurg
2024 (Swedish)In: Modern Psykologi, ISSN 2000-4087, no 5, p. 18-28Article in journal (Other (popular science, discussion, etc.)) Published
Place, publisher, year, edition, pages
Vetenskapsmedia i Sverige AB, 2024
National Category
Neurosciences
Research subject
Neurosurgery
Identifiers
urn:nbn:se:umu:diva-229519 (URN)
Available from: 2024-09-11 Created: 2024-09-11 Last updated: 2024-09-12Bibliographically approved
Sjöberg, R. L. (2024). Kan minnen lockas fram ur våra hjärnor?. Svenska Dagbladet (2024-10-15)
Open this publication in new window or tab >>Kan minnen lockas fram ur våra hjärnor?
2024 (Swedish)In: Svenska Dagbladet, ISSN 1101-2412, no 2024-10-15Article in journal, News item (Other (popular science, discussion, etc.)) Published
Place, publisher, year, edition, pages
Stockholm: Hb Svenska dagbladets AB & Co, 2024
National Category
Neurosciences
Research subject
Neurosurgery
Identifiers
urn:nbn:se:umu:diva-230893 (URN)
Available from: 2024-10-15 Created: 2024-10-15 Last updated: 2024-10-16Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/rlsjoberg

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