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Sjöberg, Rickard LORCID iD iconorcid.org/rlsjoberg
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Publications (10 of 62) Show all publications
Sjöberg, R. L., Wu, W.-Y. Y., Dahlin, A. M., Tsavachidis, S., Bondy, M. L. & Melin, B. S. (2019). Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study. Journal of Neuro-Oncology, 145(2), 287-294
Open this publication in new window or tab >>Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study
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2019 (English)In: Journal of Neuro-Oncology, ISSN 0167-594X, E-ISSN 1573-7373, Vol. 145, no 2, p. 287-294Article in journal (Refereed) Published
Abstract [en]

Background: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine. Preclinical studies suggest that this enzyme may contribute to an environment favorable for growth of malignant glioma. The MAO-A gene is located on the X-chromosome and has at least one functional genetic polymorphism. The aim of the present study was to explore possible effects of MAO-A genotype on development of glioblastoma in males.

Methods: Genotypes for 437 glioma cases and 876 population-based controls from the Swedish Glioma International Case–Control study (GICC) were compared. We analyzed the germline DNA using the Illumina Oncoarray. We selected seven single nucleotide polymorphisms (SNPs) located in the MAO-A gene, and imputed genotypes based on data from the 1000 genomes project. We used 1579 male glioblastoma cases and 1875 controls comprising the whole GICC cohort for subsequent validation of findings.

Results: The rs144551722 SNP was a significant predictor of development of glioblastoma in males (p-value = 0.0056) but not in females even after correction for multiple testing. We conducted haplotype analysis to confirm an association between MAO-A gene and risk of glioblastoma (p-value = 0.016). We found similar results in the validation sample.

Conclusions: These results suggest the possibility of a role for the MAO-A enzyme and the MAO-A gene in the development of glioblastoma in males.

Place, publisher, year, edition, pages
Springer, 2019
Keywords
MAOA genetics glioblastoma males
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-166478 (URN)10.1007/s11060-019-03294-w (DOI)000496571900010 ()31556016 (PubMedID)
Funder
NIH (National Institute of Health), R01CA139020NIH (National Institute of Health), R01 CA139020
Available from: 2020-01-02 Created: 2020-01-02 Last updated: 2020-01-02Bibliographically approved
Sjöberg, R. L., Stålnacke, M., Andersson, M. & Eriksson, J. (2019). The supplementary motor area syndrome and cognitive control. Neuropsychologia, 129, 141-145
Open this publication in new window or tab >>The supplementary motor area syndrome and cognitive control
2019 (English)In: Neuropsychologia, ISSN 0028-3932, E-ISSN 1873-3514, Vol. 129, p. 141-145Article in journal (Refereed) Published
Abstract [en]

The Supplementary Motor Area (SMA)-syndrome is a transient disturbance of the ability to initiate voluntary motor and speech actions that will often occur immediately after neurosurgical resections in the dorsal superior frontal gyrus but will typically have disappeared after 3 months. The purpose of the present study was to investigate the extent to which this syndrome is associated with alterations in cognitive control. Five patients who were to different extents affected by the SMA-syndrome after surgery for WHO grade II gliomas in the left hemisphere, were tested with the color word interference (Stroop) test; the Bergen dichotic listening test and for letter and category verbal fluency before surgery, 1–2 days after surgery and approximately 3 months after surgery. Results suggest that the motor symptoms known as the SMA syndrome co-occur with pronounced deficits in cognitive control.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Cognitive control, Executive function, SMA-syndrome, Supplementary motor area, Stroop test, Dichotic listening
National Category
Neurosciences
Identifiers
urn:nbn:se:umu:diva-164009 (URN)10.1016/j.neuropsychologia.2019.03.013 (DOI)000493911900014 ()30930302 (PubMedID)
Funder
Västerbotten County Council
Available from: 2019-10-12 Created: 2019-10-12 Last updated: 2019-12-03Bibliographically approved
Philipsson, J., Sjöberg, R. L., Yelnik, J. & Blomstedt, P. (2017). Acute severe depression induced by stimulation of the right globus pallidus internus. Neurocase, 23(1), 84-87
Open this publication in new window or tab >>Acute severe depression induced by stimulation of the right globus pallidus internus
2017 (English)In: Neurocase, ISSN 1355-4794, E-ISSN 1465-3656, Vol. 23, no 1, p. 84-87Article in journal (Refereed) Published
Abstract [en]

Depressive symptoms may occur after Deep Brain Stimulation (DBS) in the subthalamic nucleus. This is often explained by reduced pharmacological treatment after surgery, and not as a direct effect of DBS. Pallidal DBS seems not to be associated with such side effects and have not, to our knowledge, previously been reported. We present a patient with acute depressive symptoms induced by pallidal DBS. We believe this case strengthen the hypothesis that the basal ganglia and structures involved in the functional connectome of these nucleuses play a role not only in regulation of movement but also in regulation of mood.

Place, publisher, year, edition, pages
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2017
Keywords
Deep brain stimulation (DBS), Parkinson's disease, pallidum, basal ganglia, depression
National Category
Neurology
Identifiers
urn:nbn:se:umu:diva-134830 (URN)10.1080/13554794.2017.1284243 (DOI)000399644200015 ()28165911 (PubMedID)
Available from: 2017-05-24 Created: 2017-05-24 Last updated: 2018-06-09Bibliographically approved
Sjöberg, R. L. (2017). Witch persecutions and torture: Comment on Alison and Alison (2017). American Psychologist, 72(7), 703-704
Open this publication in new window or tab >>Witch persecutions and torture: Comment on Alison and Alison (2017)
2017 (English)In: American Psychologist, ISSN 0003-066X, E-ISSN 1935-990X, Vol. 72, no 7, p. 703-704Article in journal, Editorial material (Refereed) Published
Abstract [en]

In their article Alison and Alison (2017) argue that historical experiences speak against the efficacy of torture. In this comment experiences from the witch persecutions in Europe during the 15th to 17th centuries that support this notion are discussed. Converging data suggests that torture was often instrumental in making large numbers of suspects confess to flying children through the air to nocturnal satanic meetings, during this period. A comparison of the number of false self incriminating confessions given during the Swedish witch trial in the parish of Rättvik 1671 (before royal sanction of torture was given) and the parish of Ockelbo 1675 (after royal sanction of torture was given) is used to illustrate this point.

Keywords
torture, enhanced interrogations, witch persecutions, false confessions
National Category
Applied Psychology
Identifiers
urn:nbn:se:umu:diva-141451 (URN)10.1037/amp0000200 (DOI)000412440500010 ()29016176 (PubMedID)
Available from: 2017-11-04 Created: 2017-11-04 Last updated: 2018-06-09Bibliographically approved
Tikkanen, R., Saukkonen, T., Fex, M., Bennet, H., Rautiainen, M.-R. -., Paunio, T., . . . Virkkunen, M. (2016). Influence of a HTR2B Stop Codon on Glucagon Homeostasis and Glucose Excursion in Non-Diabetic Men. Experimental and clinical endocrinology & diabetes, 124(9), 529-534
Open this publication in new window or tab >>Influence of a HTR2B Stop Codon on Glucagon Homeostasis and Glucose Excursion in Non-Diabetic Men
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2016 (English)In: Experimental and clinical endocrinology & diabetes, ISSN 0947-7349, E-ISSN 1439-3646, Vol. 124, no 9, p. 529-534Article in journal (Refereed) Published
Abstract [en]

Limited data are available about the role of the serotonin 2B (5-HT2B) receptor in the function of human islets. This study aimed to test whether the 5-HT2B receptor contributes to glucose, insulin, and glucagon homeostasis in humans, utilizing a hereditary loss-of-function gene mutation in the receptor, which causes a 50% reduction in the production of the receptor protein in heterozygotes. This clinical study enrolled participants recruited by newspaper advertisements and from mental status examinations. A cohort of participants from a young Finnish founder population composed of 68 non-diabetic males with a mean age of 30 was divided into groups for comparison based on being a 5-HT2B receptor loss-of-function gene mutation (HTR2B Q20*) heterozygote carrier (n=11) or not (n=57). Serum levels of glucose, insulin, and glucagon were measured in a 5h oral glucose tolerance test using a 75g glucose challenge. Insulin resistance, insulin sensitivity, and beta cell activity were calculated using the homeostasis model assessment (HOMA2) and whole body insulin sensitivity index (WBISI), as well as the ratio of glucagon to insulin was noted. The areas under the curves (AUCs) were also determined. Concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) were measured in cerebrospinal fluid (CSF). Covariate adjusted mean score comparisons were applied. Lower glucagon secretion and decreased glucose excursion were observed among HTR2B Q20* carriers as compared with individuals who were homozygotes for the wild-type Q20 allele (controls). No differences in insulin secretion, beta cell activity, insulin resistance, or insulin sensitivity were observed. The glucagon to insulin ratio differed between the HTR2B Q20* carriers and controls. CSF levels of 5-HIAA were similar between groups. Our findings indicate that the 5-HT2B receptor may contribute to the regulation of human glucagon and glucose homeostasis and the interplay between glucagon and insulin secretion.

Keywords
glucose, glucagon, serotonin 2B receptor, oral glucose tolerance test, insulin resistance, BMI
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-127723 (URN)10.1055/s-0042-109263 (DOI)000386313300002 ()27437919 (PubMedID)
Available from: 2016-12-15 Created: 2016-11-18 Last updated: 2018-06-09Bibliographically approved
Tikkanen, R., Saukkonen, T., Fex, M., Bennet, H., Rautiainen, M.-R., Paunio, T., . . . Virkkunen, M. (2016). The effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males. Journal of Psychiatric Research, 81, 79-86
Open this publication in new window or tab >>The effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males
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2016 (English)In: Journal of Psychiatric Research, ISSN 0022-3956, E-ISSN 1879-1379, Vol. 81, p. 79-86Article in journal (Refereed) Published
Abstract [en]

Herein, we examined insulin resistance (IR), insulin sensitivity (IS), beta cell activity, and glucose metabolism in subjects with antisocial personality disorder (ASPD), and whether the serotonin 2B (5-HT2B) receptor and testosterone have a role in energy metabolism. A cohort of subjects belonging to a founder population that included 98 ASPD males, aged 25-30, was divided into groups based on the presence of a heterozygous 5-HT2B receptor loss-of-function gene mutation (HTR2B Q20*; n = 9) or not (n = 89). Serum glucose and insulin levels were measured in a 5 h oral glucose tolerance test (75 g) and indices describing IR, IS, and beta cell activity were calculated. Body mass index (BMI) was also determined. Concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid were measured in cerebrospinal fluid, and testosterone levels from serum. An IR-like state comprising high IR, low IS, and high beta cell activity indices was observed among ASPD subjects without the HTR2B Q20* allele. By contrast, being an ASPD HTR2B Q20* carrier appeared to be preventive of these pathophysiologies. The HTR2B Q20* allele and testosterone predicted lower BMI independently, but an interaction between HTR2B Q20* and testosterone lead to increased insulin sensitivity among HTR2B Q20* carriers with low testosterone levels. The HTR2B Q20* allele also predicted reduced beta cell activity and enhanced glucose metabolism. Reduced 5-HT2B receptor function at low or normal testosterone levels may be protective of obesity. Results were observed among Finnish males having an antisocial personality disorder, which limits the generality.

Keywords
ASPD, 5-HT2B receptor, HTR2B, Testosterone, Insulin resistance, BMI
National Category
Psychiatry
Identifiers
urn:nbn:se:umu:diva-130067 (URN)10.1016/j.jpsychires.2016.06.019 (DOI)000384855400011 ()27420381 (PubMedID)
Available from: 2017-01-12 Created: 2017-01-11 Last updated: 2018-06-09Bibliographically approved
Sjöberg, R. L., Bergenheim, T., Mörén, L., Antti, H., Lindgren, C., Naredi, S. & Lindvall, P. (2015). Blood Metabolomic Predictors of 1-Year Outcome in Subarachnoid Hemorrhage. Neurocritical Care, 23(2), 225-232
Open this publication in new window or tab >>Blood Metabolomic Predictors of 1-Year Outcome in Subarachnoid Hemorrhage
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2015 (English)In: Neurocritical Care, ISSN 1541-6933, E-ISSN 1556-0961, Vol. 23, no 2, p. 225-232Article in journal (Refereed) Published
Abstract [en]

Delayed neurological deficit (DND) is the most important cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH) whose aneurysms have been secured. However, the methods currently used to predict the development of DND, such as trans-cranial Doppler or levels biochemical markers in blood and cerebrospinal fluid are not very accurate. Venous blood was drawn from 50 patients with SAH, admitted to the neurosurgical department UmeAyen University Hospital, at day 1-3 and day 7 after the bleed. The clinical status of the patients was followed up approximately 1 year after this episode and classified according to the Glasgow Outcome Score (GOS). Results showed considerable differences in blood metabolomic patterns between day 1-3 and 7 after the hemorrhage. Fifty-six out of 98 metabolites could be identified from our in-house library and 17 of these metabolites changed significantly from day 1-3 to 7 after the bleed. One of these, myo-inositol, was predictive of clinical outcome even after correction for multiple testing. An estimation of the diagnostic accuracy of high levels of this substance in predicting good outcome (GOS 4-5) yielded a sensitivity of .763 and a specificity of .5 at the optimal cut off point. SAH is an event with a profound effect on blood metabolomics profiles. Myo-inositol might be an interesting compound for future study to focus on in the search for metabolic markers in venous blood of delayed neurological deterioration in SAH patients.

Place, publisher, year, edition, pages
Springer, 2015
Keywords
Delayed neurological deficit, Myo-inositol, Metabolomics, Subarachnoid hemorrhage, Vasospasm, nous blood
National Category
Neurosciences
Identifiers
urn:nbn:se:umu:diva-109362 (URN)10.1007/s12028-014-0089-2 (DOI)000360700700012 ()25667130 (PubMedID)
Available from: 2015-09-30 Created: 2015-09-25 Last updated: 2018-06-07Bibliographically approved
Sjöberg, R. L. (2015). Charcots fotnot: svår för vetenskapen att förtränga. Läkartidningen, 112(18-19)
Open this publication in new window or tab >>Charcots fotnot: svår för vetenskapen att förtränga
2015 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 112, no 18-19Article in journal (Other academic) Published
Place, publisher, year, edition, pages
Stockholm: Sveriges läkarförbund, 2015
National Category
Neurosciences
Identifiers
urn:nbn:se:umu:diva-111311 (URN)25919671 (PubMedID)
Available from: 2015-11-13 Created: 2015-11-13 Last updated: 2018-06-07Bibliographically approved
Sjöberg, R. L., Häggström, B., Philipsson, J., Linder, J., Hariz, M. & Blomstedt, P. (2015). Laterality and deep brain stimulation of the subthalamic nucleus: applying a dichotic listening task to patients treated for Parkinson's disease. Neurocase, 21(5), 601-606
Open this publication in new window or tab >>Laterality and deep brain stimulation of the subthalamic nucleus: applying a dichotic listening task to patients treated for Parkinson's disease
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2015 (English)In: Neurocase, ISSN 1355-4794, E-ISSN 1465-3656, Vol. 21, no 5, p. 601-606Article in journal (Refereed) Published
Abstract [en]

Ear advantage during a dichotic listening task tends to mirror speech lateralization. Previous studies in stroke patients have shown that lesions in the dominant hemisphere often seem to produce changes in ear advantage. In this study six Parkinson's disease (PD) patients treated for motor symptoms with deep brain stimulation (DBS) of the left subthalamic nucleus (STN) were tested preoperatively and at approximately 6 and 18months postoperatively with a dichotic listening task. Results show a significant decline of the right ear advantage over time. In three of the patients a right ear advantage preoperativley changed to a left ear advantage 18months postoperatively. This suggests the possibility that additional longitudinal studies of this phenomenon could serve as a model for understanding changes in indirect measures of speech lateralization in stroke patients.

Keywords
hemispheric dominance, subthalamic nucleus, deep brain stimulation, dichotic listening, aphasia
National Category
Neurology Psychiatry Psychology
Identifiers
urn:nbn:se:umu:diva-105995 (URN)10.1080/13554794.2014.960427 (DOI)000356354500008 ()25254607 (PubMedID)
Available from: 2015-07-09 Created: 2015-07-03 Last updated: 2018-06-07Bibliographically approved
Lindholm, T., Sjöberg, R. & Memon, A. (2014). Misreporting signs of child abuse: The role of decision-making and outcome information. Scandinavian Journal of Psychology, 55(1), 1-9
Open this publication in new window or tab >>Misreporting signs of child abuse: The role of decision-making and outcome information
2014 (English)In: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 55, no 1, p. 1-9Article in journal (Refereed) Published
Abstract [en]

Two studies provided evidence that a decision to report an ambiguous case of child abuse affected subsequent memory of the case information, such that participants falsely recognized details that were not presented in the original information, but that are schematically associated with child abuse. Moreover, post-decision information that the child had later died from abuse influenced the memory reports of participants who had chosen not to report the case, increasing their reports of false schema-consistent details. This suggests that false decision-consistent memories are primarily due to sense-making, schematic processing rather than the motivation to justify the decision. The present findings points to an important mechanism by which decision information can become distorted in retrospect, and emphasize the difficulties of improving future decision-making by contemplating past decisions. The results also indicate that decisions may generate false memories in the apparent absence of external suggestion or misleading information. Implications for decision-making theory, and applied practices are discussed.

Keywords
False memory, decision-making, post-decision information, hindsight
National Category
General Practice
Identifiers
urn:nbn:se:umu:diva-86834 (URN)10.1111/sjop.12096 (DOI)000330726100001 ()
Available from: 2014-03-17 Created: 2014-03-11 Last updated: 2018-06-08Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/rlsjoberg

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