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Johnson, Owe
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Publications (10 of 17) Show all publications
Lysell-Bergström, C., Johansson, B., Widman, L., Johnson, O. & Mörner, S. (2014). Progressive conduction disease late after adriamycin treatment of lymphoma, despite normalised ejection fraction [Letter to the editor]. International Cardiovascular Forum Journal, 1(3), 160-161
Open this publication in new window or tab >>Progressive conduction disease late after adriamycin treatment of lymphoma, despite normalised ejection fraction
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2014 (English)In: International Cardiovascular Forum Journal, ISSN 2410-2636, Vol. 1, no 3, p. 160-161Article in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
Barcaray International Publishing, 2014
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-107594 (URN)10.17987/icfj.v1i3.76 (DOI)
Available from: 2015-08-25 Created: 2015-08-25 Last updated: 2018-06-07Bibliographically approved
Söderström, E., Eliasson, M., Johnson, O., Hallmans, G., Weinehall, L., Jansson, J.-H. & Hultdin, J. (2013). Plasma folate, but not homocysteine, is associated with Apolipoprotein A1 levels in a non-fortified population. Lipids in Health and Disease, 12, 74
Open this publication in new window or tab >>Plasma folate, but not homocysteine, is associated with Apolipoprotein A1 levels in a non-fortified population
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2013 (English)In: Lipids in Health and Disease, ISSN 1476-511X, E-ISSN 1476-511X, Vol. 12, p. 74-Article in journal (Refereed) Published
Abstract [en]

Background: Elevated total plasma homocysteine (tHcy) in humans is associated with cardiovascular disease but prevention trials have failed to confirm causality. Reported reasons for this association have been that homocysteine and its major genetic determinant methylenetetrahydrofolate reductase (MTHFR) may have an effect on HDL and Apolipoprotein (Apo) A1 levels. We wanted to study if tHcy and its major determinants were correlated with Apo A1 levels in a large population without folate fortification. Methods: This study was a prospective incident nested case-referent study within the Northern Sweden Health and Disease Study Cohort (NSHDSC), including 545 cases with first myocardial infarction and 1054 matched referents, median age at inclusion was 59 years. Univariate and multiple regression analyzes was used to study the associations between apolipoproteins Apo A1 and B, tHcy, folate and vitamin B12 in plasma as well as MTHFR polymorphisms 677C>T and 1298A>C. Results: Apo A1 and Apo B were strongly associated with the risk of a first myocardial infarction. tHcy was not associated with Apo A1 levels. Instead, folate had an independent positive association with Apo A1 levels in univariate and multiple regression models. The associations were seen in all men and women, among referents but not among cases. MTHFR polymorphisms had no clear effect on Apo A1 levels. Conclusions: Analyzing over 1500 subjects we found an independent positive association between plasma folate (major dietary determinant of tHcy) and Apo A1 levels among those who later did not develop a first myocardial infarction. No association was seen between tHcy and Apo A1.

Keywords
Apolipoprotein, Homocysteine, Myocardial infarction, Folate, Epidemiology
National Category
Cell and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-76807 (URN)10.1186/1476-511X-12-74 (DOI)000320045300001 ()
Available from: 2013-07-16 Created: 2013-07-15 Last updated: 2018-06-08Bibliographically approved
Ng, N., Johnson, O., Lindahl, B. & Norberg, M. (2012). A reversal of decreasing trends in population cholesterol levels in Västerbotten County, Sweden. Global Health Action, 5, 10367
Open this publication in new window or tab >>A reversal of decreasing trends in population cholesterol levels in Västerbotten County, Sweden
2012 (English)In: Global Health Action, ISSN 1654-9716, E-ISSN 1654-9880, Vol. 5, p. 10367-Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: High cholesterol is identified as a major risk factor for chronic non-communicable diseases, especially cardiovascular and cerebrovascular diseases. Monitoring trends of cholesterol levels and comparing trends across population groups are important to assess population distribution and risks related to cholesterol change over time. Cholesterol surveillance data are lacking, even in high-income countries.

OBJECTIVES: To describe the trends in cholesterol and triglyceride levels in different population groups and to estimate the risk of developing hypercholesterolemia and hypertriglyceridemia in Västerbotten County, Sweden during 1990-2010.

DESIGNS AND METHODS: Since 1990, 133,082 individuals living in Västerbotten County, Northern Sweden, invited on their 30th, 40th, 50th and 60th birthdays, participated in the Västerbotten Intervention Program. Ten years after baseline data collection, 34,868 individuals were surveyed for a second time. In addition to a self-administered health questionnaire (that included information on socioeconomic status, demographics, self-reported health and lifestyle behaviours), blood cholesterol and triglyceride were examined.

RESULTS: The level and prevalence of hypercholesterolemia decreased significantly from 1990 to 2007, but the trends began to increase during 2008-2010 in men, women, and in all educational groups. Men had significantly higher serum triglyceride levels than women and their cholesterol levels were similar to those of the women. This study shows that those with basic education and who live in rural inlands had consistently higher triglyceride level than those who live in the city and have higher educational attainments. People with basic education are also at higher risk of developing hypercholesterolemia and hypertriglyceridemia at 10-year follow-up; the risk is much higher among the older cohorts, particularly women. During 1990-2010, the proportion of participants who reported treatment with lipid-lowering agents increased from 1.1% to 9.6% among men and 0.5% to 5.3% among women. About 60% of those treated achieved treatment goals for cholesterol or triglycerides.

CONCLUSIONS: The increasing trend in cholesterol level in the Västerbotten population during 2008-2010 needs to be closely monitored. Addressing the unequal distribution of cholesterol, as well as other risk factors such as obesity, physical inactivity, high blood glucose, among those with basic education, and particularly among populations in rural areas are important to prevent higher burdens of chronic non-communicable diseases in this population.

Place, publisher, year, edition, pages
Co-Action Publishing, 2012
Keywords
cholesterol, hypercholesterolemia, triglyceride, dyslipidaemia, trends, education, longitudinal studies, Sweden
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-53955 (URN)10.3402/gha.v5i0.10367 (DOI)22468143 (PubMedID)
Available from: 2012-04-10 Created: 2012-04-10 Last updated: 2018-06-08Bibliographically approved
Fjellström, M., Naredi, S., Sawert, B. & Johnson, O. (2012). En bro mellan högre utbildning och profession: Utbildning för kliniska handledare i läkarutbildning. In: Nu 2012 Göteborg 17-19 oktober 2012: Gränslöst lärande. Paper presented at Nu 2012 Göteborg 17-19 oktober 2012 (pp. 131-132). Göteborg
Open this publication in new window or tab >>En bro mellan högre utbildning och profession: Utbildning för kliniska handledare i läkarutbildning
2012 (Swedish)In: Nu 2012 Göteborg 17-19 oktober 2012: Gränslöst lärande, Göteborg, 2012, p. 131-132Conference paper, Oral presentation with published abstract (Refereed)
Abstract [sv]

I samband med att läkarutbildningen vid Umeå universitet skulle regionaliseras togs beslut om att samtliga kliniska handledare, varav flertalet är landstingsanställda läkare, i regionen (Västerbotten, Norrbotten, Jämtland och Västernorrland) skulle erbjudas handledarutbildning. Utbildningen skulle stärka kopplingen mellan de högskoleförlagda och de verksamhetsförlagda delarna av utbildningen samt stödja en handledarroll starkt utmanad av sjukvårdens verksamhetskrav.  Läkarutbildningen har utökats kraftigt de senaste femton åren samtidigt som kraven ökat på produktivitet inom hälso- och sjukvården. Resultatet har blivit många studenter ute i klinisk verksamhet med kliniska handledare som ofta varken har en tydlig rolldefinition som handledare, aktuell kunskap om vilka mål som skall uppnås eller redskap för hur handledning skall genomföras i en splittrad och tidspressad vardag. För studenterna har problemen yttrat sig i form av brist på tid med, eller avsaknad av, handledare och sämre möjligheter att fullfölja praktiska utbildningsmoment (Läkartidningen, 2008:38; MSF Handledningsenkät 2011). Socialstyrelsen har också uppmärksammat behovet av handledarutbildning genom att ställa krav på handledarutbildning för handledare i specialiseringstjänstgöring (ST) för läkare (SOSFS 2008:17, 3 kap).

Fokus för handledarutbildningen blev att utveckla de kliniska handledarnas kunskaper om och förmåga att handleda i kliniska situationer samt att stimulera ett reflekterande och prövande förhållningssätt till studenternas lärande och den egna handledarrollen. Teman som ingår är: Mål och regelverk för läkarprogrammet, planering av klinisk handledning, att stödja ett reflekterat och handlingsinriktat lärande, att handleda, samtal, feedback och bedömning samt den professionella handledaren. Utbildningen, som genomförs som ett samarbete mellan universitetet och de fyra landstingen, omfattar tre dagar med ett eget arbete som genomförs av deltagarna mellan kursdag 2 och 3. Sedan 2009 har 177 kliniska handledare utbildats. Utvärderingar genomförda i samband med kursens genomförande har visat att de kliniska handledarna genomgående är mycket positiva till utbildningen. Det som särskilt lyfts fram är möjligheten till egen reflektion, praktisk problemlösning tillsammans med andra handledare samt en starkare koppling till utbildningsuppdraget genom den ökade kunskapen om lärande och högskolans regelverk.

Under den period som handledarutbildningen genomförts har intresset väckts för att handledarutbildning för kliniska handledare skall genomföras i två steg. Ett inledande steg fokuserat på grundläggande handledarkunskap och handledning inom läkarprogrammet som skulle genomföras under läkares specialiseringstjänstgöring. Dessutom ett senare steg, riktat till färdiga specialistkompetenta läkare, som fokuserar på den mer långsiktiga och individnära handledning som genomförs under specialisttjänstgöringen. Idag för läkarprogrammet vid Umeå universitet samtal med två landsting i regionen om möjligheten att bedriva den grundläggande handledarutbildningen.

Place, publisher, year, edition, pages
Göteborg: , 2012
Keywords
Klinisk handledning; Handledarutbildning; Läkarutbildning
National Category
Pedagogy
Research subject
Education
Identifiers
urn:nbn:se:umu:diva-66303 (URN)
Conference
Nu 2012 Göteborg 17-19 oktober 2012
Available from: 2013-02-18 Created: 2013-02-18 Last updated: 2018-06-08Bibliographically approved
Lindahl, B., Nilssön, T. K., Borch-Johnsen, K., Røder, M. E., Söderberg, S., Widman, L., . . . Jansson, J.-H. (2009). A randomized lifestyle intervention with 5-year follow-up in subjects with impaired glucose tolerance: pronounced short-term impact but long-term adherence problems. Scandinavian Journal of Public Health, 37(4), 434-442
Open this publication in new window or tab >>A randomized lifestyle intervention with 5-year follow-up in subjects with impaired glucose tolerance: pronounced short-term impact but long-term adherence problems
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2009 (English)In: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, Vol. 37, no 4, p. 434-442Article in journal (Refereed) Published
Abstract [en]

AIMS: To compare data on cardiovascular risk factor changes in lipids, insulin, proinsulin, fibrinolysis, leptin and C-reactive protein, and on diabetes incidence, in relation to changes in lifestyle.

METHODS: The study was a randomized lifestyle intervention trial conducted in northern Sweden between 1995 and 2000, in 168 individuals with impaired glucose tolerance (IGT) and body mass index above 27 at start. The intensive intervention group (n = 83) was subjected to a 1-month residential lifestyle programme. The usual care group (n = 85) participated in a health examination ending with a single counselling session. Follow-up was conducted at 1, 3 and 5 years.

RESULTS: At 1-year follow-up, an extensive cardio-metabolic risk factor reduction was demonstrated in the intensive intervention group, along with a 70% decrease of progress to type 2 diabetes. At 5-year follow-up, most of these beneficial effects had disappeared. Reported physical activity and fibre intake as well as high-density lipoprotein cholesterol were still increased, and fasting insulin and proinsulin were lower.

CONCLUSIONS: The intervention affected several important cardio-metabolic risk variables beneficially, and reduced the risk for type 2 diabetes, but the effects persisted only as long as the new lifestyle was maintained. Increased physical activity seemed to be the behaviour that was most easy to preserve.

National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-23461 (URN)10.1177/1403494808101373 (DOI)19181821 (PubMedID)
Available from: 2009-06-18 Created: 2009-06-18 Last updated: 2018-08-31Bibliographically approved
Eriksson, M., Johnson, O., Boman, K., Hallmans, G., Hellsten, G., Nilsson, T. K. & Söderberg, S. (2008). Improved fibrinolytic activity during exercise may be an effect of the adipocyte-derived hormones leptin and adiponectin. Thrombosis Research, 122(5), 701-708
Open this publication in new window or tab >>Improved fibrinolytic activity during exercise may be an effect of the adipocyte-derived hormones leptin and adiponectin
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2008 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 122, no 5, p. 701-708Article in journal (Refereed) Published
Abstract [en]
Introduction

Physical activity is associated with improved fibrinolytic activity and reduced risk for cardiovascular disease. High levels of leptin and low levels of adiponectin, both adipocyte-derived hormones, or adipokines, are related to dysfibrinolysis and risk for cardiovascular disease. In this study, we explored if improved fibrinolytic activity during exercise could be linked to changes in leptin and adiponectin levels.

Materials and methods

Twenty healthy men (mean age 36 years) participated in a 14-day long skiing expedition in the Swedish mountains. They were randomly assigned to either a 40% or a 30% fat-based diet. Anthropometry, lipids, fibrinolytic activity (PAI-1 activity, tPA activity and mass) and adipokines (leptin and adiponectin) were measured before, during and six weeks after the expedition.

Results

PAI-1 activity and circulating levels of leptin decreased whereas levels of adiponectin increased during exercise. The fall in PAI-1 activity showed a strong linear association with changes in leptin and adiponectin levels (p = 0.001 and p < 0.001, respectively). Changes in leptin and adiponectin levels were independent of decreasing waist circumference. However, the association between anthropometric measures and adipokines changed considerably during the expedition. Adiponectin was weakly and negatively associated with BMI at baseline. In contrast, there was a strong positive association between adiponectin and BMI after two weeks of exercise, whereas the association between leptin and BMI became less pronounced. In addition, increasing leptin and decreasing adiponectin levels were associated with increasing PAI-1 activity during the six weeks following the expedition. After six weeks of normal activity, fibrinolytic activity and hormone levels returned towards baseline levels.

Conclusion

Heavy exercise induced improved fibrinolytic activity, which was associated independently with changes in circulating levels of the adipocyte-derived hormones leptin and adiponectin. Improved fibrinolytic activity (and reduced risk for cardiovascular disease) related to physical activity could possibly be mediated by leptin and adiponectin.

Keywords
Fibrinolytic activity; Adipocyte-derived hormones; Leptin; Adiponectin; Healthy men; Physical activity; Clinical experiment; Repeated measures
Identifiers
urn:nbn:se:umu:diva-10470 (URN)10.1016/j.thromres.2008.01.010 (DOI)18387655 (PubMedID)
Available from: 2008-09-15 Created: 2008-09-15 Last updated: 2018-08-31Bibliographically approved
Eriksson, M. A., Rask, E., Johnson, O., Carlström, K., Ahrén, B., Eliasson, M., . . . Söderberg, S. (2008). Sex-related differences in the associations between hyperleptinemia, insulin resistance and dysfibrinolysis. Blood Coagulation and Fibrinolysis, 19(7), 625-632
Open this publication in new window or tab >>Sex-related differences in the associations between hyperleptinemia, insulin resistance and dysfibrinolysis
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2008 (English)In: Blood Coagulation and Fibrinolysis, ISSN 0957-5235, E-ISSN 1473-5733, Vol. 19, no 7, p. 625-632Article in journal (Refereed) Published
Abstract [en]

The adipocyte-derived hormone leptin is associated with insulin resistance and reduced fibrinolytic status--or dysfibrinolysis--in humans. As leptin associates differentially to the development of cardiovascular disease and diabetes in men and women, we hypothesized that leptin and insulin sensitivity are related to dysfibrinolysis in a sex-dependent manner. Thirty-two men and 40 women were recruited from the Monitoring of trends and determinants in Cardiovascular disease (MONICA) population sample, representing the highest and lowest quartiles of fasting insulin levels. Lipids, fibrinolytic status [plasminogen activator inhibitor 1 (PAI-1) activity, tissue plasminogen activator (tPA) mass and activity, and tPA-PAI complex], leptin, testosterone and sex-hormone-binding globulin were measured. Insulin sensitivity was estimated using the euglycaemic clamp technique. Body composition was determined by bioimpedance. Determinants for circulating levels of fibrinolytic factors were explored in a multivariate linear regression analysis. Levels of fibrinolytic variables and estimated insulin sensitivity did not differ between men and women. Leptin was independently associated with reduced fibrinolytic status (high PAI-1 activity, low tPA activity, high tPA mass, and high tPA-PAI complex) in men (P < 0.001-0.002). In women, fat mass and/or insulin sensitivity were related to these factors (P < 0.001-0.03), and leptin only to reduced tPA activity (P = 0.002). Hyperleptinemia, dysfibrinolysis, insulin sensitivity and androgenicity associate differentially in men and women.

Keywords
androgens; dysfibrinolysis; hyperleptinemia; insulin resistance; sex
Identifiers
urn:nbn:se:umu:diva-18465 (URN)10.1097/MBC.0b013e3283099046 (DOI)18832901 (PubMedID)
Available from: 2009-02-10 Created: 2009-02-10 Last updated: 2018-06-09Bibliographically approved
Lindholm, A., Bixo, M., Björn, I., Wölner-Hanssen, P., Eliasson, M., Larsson, A., . . . Poromaa, I. S. (2007). Effect of sibutramine on weight reduction in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.. Fertil Steril
Open this publication in new window or tab >>Effect of sibutramine on weight reduction in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
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2007 (English)In: Fertil Steril, ISSN 1556-5653Article in journal (Refereed) Published
Identifiers
urn:nbn:se:umu:diva-16460 (URN)17603048 (PubMedID)
Available from: 2007-09-28 Created: 2007-09-28 Last updated: 2018-06-09Bibliographically approved
Rantapää-Dahlqvist, S., Engstrand, S., Berglin, E. & Johnson, O. (2006). Conversion towards an atherogenic lipid profile in rheumatoid arthritis patients during long-term infliximab therapy.. Scand J Rheumatol, 35(2), 107-11
Open this publication in new window or tab >>Conversion towards an atherogenic lipid profile in rheumatoid arthritis patients during long-term infliximab therapy.
2006 (English)In: Scand J Rheumatol, Vol. 35, no 2, p. 107-11Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To analyse the effects of infliximab infusions on serum levels of lipids in patients with rheumatoid arthritis (RA) treated for 2 years. METHODS: Fifty-two patients (41 females and 11 males) with RA undergoing infliximab treatment (3 mg/kg) were consecutively recruited into the study. The mean (+/-SD) age of the patients was 54.6+/-12.5 years and mean disease duration was 14.1+/-8.6 years. Blood was sampled before infusion at baseline, and at 3, 6, 12, 18 and 24 months. Forty-one of the patients were also treated with methotrexate, 13 with other disease-modifying anti-rheumatic drugs (DMARDs) and 28 with prednisolone (<10 mg daily). For comparison, lipid levels were followed for 2 years in 70 consecutively included patients with early RA during treatment with conventional DMARDs. RESULTS: There was an initial increase in plasma levels of cholesterol, high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, and LDL/HDL and total/HDL cholesterol ratios. However, after 3 months HDL-cholesterol decreased significantly, followed after 6 months by cholesterol and LDL-cholesterol. The LDL/HDL and total/HDL-cholesterol ratios remained significantly raised. HDL-cholesterol increased and the ratios improved in patients with early RA receiving conventional treatment. The changes over time differed significantly between the patient groups. CONCLUSION: During infliximab infusion a pro-atherogenic lipid profile developed despite reduced inflammatory activity. The long-term decrease in HDL-cholesterol was unexpected considering the known effects of tumour necrosis factor-alpha (TNFalpha).

Identifiers
urn:nbn:se:umu:diva-16124 (URN)doi:10.1080/03009740500474578 (DOI)16641043 (PubMedID)
Available from: 2007-08-17 Created: 2007-08-17 Last updated: 2018-06-09Bibliographically approved
Stegmayr, B., Lalau, J.-D. & Johnsson, O. (2004). In face of the increasing efficacy of lipid-lowering therapy, is there still a place for LDL-apheresis?. Transfusion and apheresis science, 30(3), 213-220
Open this publication in new window or tab >>In face of the increasing efficacy of lipid-lowering therapy, is there still a place for LDL-apheresis?
2004 (English)In: Transfusion and apheresis science, ISSN 1473-0502, E-ISSN 1878-1683, Vol. 30, no 3, p. 213-220Article in journal (Refereed) Published
Keywords
Anticholesteremic Agents/adverse effects/blood/*therapeutic use, Blood Component Removal/*trends, Coronary Disease/etiology/mortality/prevention & control, Humans, Hyperlipidemias/blood/*therapy, Lipoproteins; LDL/adverse effects/*blood, Randomized Controlled Trials, Risk Factors, Treatment Outcome
Identifiers
urn:nbn:se:umu:diva-13153 (URN)doi:10.1016/j.transci.2003.12.002 (DOI)15172626 (PubMedID)
Available from: 2007-05-03 Created: 2007-05-03 Last updated: 2018-06-09Bibliographically approved
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