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Wallner, Bengt
Publications (7 of 7) Show all publications
Zheng, J., Rutegård, M., Santoni, G., Wallner, B., Johansson, I., Sund, M., . . . Lagergren, J. (2019). Prediabetes and diabetes in relation to risk of gastric adenocarcinoma. British Journal of Cancer, 120(12), 1147-1152
Open this publication in new window or tab >>Prediabetes and diabetes in relation to risk of gastric adenocarcinoma
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2019 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 120, no 12, p. 1147-1152Article in journal (Refereed) Published
Abstract [en]

Background: Whether prediabetes or diabetes increases the risk of gastric adenocarcinoma is not clear.

Methods: This cohort study included 111,198 participants in the Northern Swedish Health and Disease Study. The participants were followed up from November 1985 to April 2017. The exposure to prediabetes or diabetes was assessed by oral glucose tolerance tests and self-reports. The incidence of the outcome gastric adenocarcinoma was identified from the Swedish Cancer Registry. Multivariable Cox regressions were used to analyse the associations between prediabetes or diabetes and the risk of gastric adenocarcinoma, providing hazard ratios (HR) with 95% confidence intervals (CI), with adjustment for sex, age, calendar year, body mass index, tobacco smoking and education level.

Results: Compared with normoglycaemic participants, the risk of gastric adenocarcinoma was not increased among participants with prediabetes (HR 1.07, 95% CI 0.79–1.44), diabetes (HR 0.77, 95% CI 0.46–1.29) or any of these exposures (HR 0.96, 95% CI 0.73–1.27). No associations were identified between prediabetes or diabetes and the risk of gastric adenocarcinoma in stratified analyses or in analyses separating cardia and non-cardia gastric adenocarcinoma.

Conclusions: This study does not support the hypothesis that prediabetes or diabetes increases the risk of gastric adenocarcinoma.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-161450 (URN)10.1038/s41416-019-0470-1 (DOI)000470973800009 ()31061455 (PubMedID)
Funder
Swedish Research Council, VR SIMSAM D0547801Swedish Cancer Society, CAN 2015/460
Available from: 2019-07-10 Created: 2019-07-10 Last updated: 2019-07-10Bibliographically approved
Wallner, B., Björ, O., Andreasson, A., Hellström, P. M., Forsberg, A. M., Talley, N. J. & Agreus, L. (2018). Identifying clinically relevant sliding hiatal hernias: a population-based endoscopy study. Scandinavian Journal of Gastroenterology, 53(6), 657-660
Open this publication in new window or tab >>Identifying clinically relevant sliding hiatal hernias: a population-based endoscopy study
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2018 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 53, no 6, p. 657-660Article in journal (Refereed) Published
Abstract [en]

Objectives: The clinical relevance of small to moderate sliding hiatal hernias is controversial. The aims of the present study were to (1) investigate which symptoms are associated with sliding hiatal hernias and (2) define the length of a sliding hiatal hernia at which gastrointestinal symptoms occur.

Methods: A study population representative of the general Swedish population answered a questionnaire regarding gastrointestinal symptoms and was investigated with an upper endoscopy. The length of any sliding hiatal hernia was measured.

Results: Only reflux-related symptoms were associated with length of the hiatal hernia (acid regurgitation OR 1.46, CI 1.19–1.79, heartburn OR 1.27, CI 1.05–1.54), and the association did not become significant until an axial hiatal hernia length of 2 cm.

Conclusions: Only reflux symptoms could be attributed to sliding hiatal hernias. Hiatal hernias less than 2 cm should be considered clinically insignificant.

Place, publisher, year, edition, pages
Taylor & Francis, 2018
Keywords
Endoscopy, sliding hiatal hernia, gastroesophageal reflux, gastroesophageal junction
National Category
Gastroenterology and Hepatology
Identifiers
urn:nbn:se:umu:diva-151197 (URN)10.1080/00365521.2018.1458896 (DOI)000438146900004 ()29616831 (PubMedID)2-s2.0-85044938707 (Scopus ID)
Available from: 2018-09-05 Created: 2018-09-05 Last updated: 2018-09-05Bibliographically approved
Agreus, L., Hellström, P. M., Talley, N. J., Wallner, B., Forsberg, A., Vieth, M., . . . Andreasson, A. (2016). Towards a healthy stomach? Helicobacter pylori prevalence has dramatically decreased over 23 years in adults in a Swedish community. United European Gastroenterology journal, 4(5), 686-696
Open this publication in new window or tab >>Towards a healthy stomach? Helicobacter pylori prevalence has dramatically decreased over 23 years in adults in a Swedish community
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2016 (English)In: United European Gastroenterology journal, ISSN 2050-6406, E-ISSN 2050-6414, Vol. 4, no 5, p. 686-696Article in journal (Refereed) Published
Abstract [en]

Background In Western countries the prevalence of Helicobacter pylori (H. pylori) infection may be declining but there is a lack of recent longitudinal population studies. We evaluated the changing epidemiology over a 23-year period in Sweden. Materials and methods In 1989, the validated Abdominal Symptom Questionnaire (ASQ) was mailed to a random sample of inhabitants (ages 22-80 years) in a Swedish community, and 1097 (87%) responded. H. pylori serology was analysed in a representative subsample (n=145). Twenty-three years later, the ASQ was mailed again using similar selection criteria, and 388 out of 1036 responders had an upper endoscopy with assessment of H. pylori and corpus atrophy status. Results The prevalence of positive H. pylori serology decreased from 37.9% (1989) to 15.8% (2012), corresponding to a decrease in odds of 75% per decade (odds ratio (OR): 0.25; 95% confidence interval (CI): 0.11-0.59, p=0.001) independent of age, gender, body mass index (BMI) and level of education, with a pattern consistent with a birth cohort effect. The prevalence increased with increasing age (p=0.001). The prevalence of H. pylori on histology in 2012 was 11.4% (95% CI 8.6-15.0). The prevalence of corpus atrophy on serology and/or histology in 2012 was 3.2% (95% CI 1.8-5.5); all cases were 57 years old. Conclusion The stomach is healthier in 2012 compared with 1989. H. pylori prevalence in adults has decreased over the last two decades to a level where clinical management might be affected.

Keywords
Helicobacter pylori, corpus atrophy, epidemiology, population-based, longitudinal
National Category
Gastroenterology and Hepatology
Identifiers
urn:nbn:se:umu:diva-130068 (URN)10.1177/2050640615623369 (DOI)000384820800006 ()27733911 (PubMedID)
Available from: 2017-01-12 Created: 2017-01-11 Last updated: 2018-06-09Bibliographically approved
Steffen, A., Huerta, J.-M., Weiderpass, E., Bueno-de-Mesquita, H. B., May, A. M., Siersema, P. D., . . . Boeing, H. (2015). General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 137(3), 646-657
Open this publication in new window or tab >>General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition
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2015 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 137, no 3, p. 646-657Article in journal (Refereed) Published
Abstract [en]

General obesity, as reflected by BMI, is an established risk factor for esophageal adenocarcinoma (EAC), a suspected risk factor for gastric cardia adenocarcinoma (GCC) and appears unrelated to gastric non-cardia adenocarcinoma (GNCC). How abdominal obesity, as commonly measured by waist circumference (WC), relates to these cancers remains largely unexplored. Using measured anthropometric data from 391,456 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC) study and 11 years of follow-up, we comprehensively assessed the association of anthropometric measures with risk of EAC, GCC and GNCC using multivariable proportional hazards regression. One hundred twenty-four incident EAC, 193 GCC and 224 GNCC were accrued. After mutual adjustment, BMI was unrelated to EAC, while WC showed a strong positive association (highest vs. lowest quintile HR = 1.19; 95% CI, 0.63-2.22 and HR = 3.76; 1.72-8.22, respectively). Hip circumference (HC) was inversely related to EAC after controlling for WC, while WC remained positively associated (HR = 0.35; 0.18-0.68, and HR=4.10; 1.94-8.63, respectively). BMI was not associated with GCC or GNCC. WC was related to higher risks of GCC after adjustment for BMI and more strongly after adjustment for HC (highest vs. lowest quintile HR = 1.91; 1.09-3.37, and HR = 2.23; 1.28-3.90, respectively). Our study demonstrates that abdominal, rather than general, obesity is an indisputable risk factor for EAC and also provides evidence for a protective effect of gluteofemoral (subcutaneous) adipose tissue in EAC. Our study further shows that general obesity is not a risk factor for GCC and GNCC, while the role of abdominal obesity in GCC needs further investigation.

National Category
Other Basic Medicine
Identifiers
urn:nbn:se:umu:diva-103287 (URN)10.1002/ijc.29432 (DOI)000354639200017 ()25598323 (PubMedID)
Available from: 2015-05-19 Created: 2015-05-19 Last updated: 2018-06-07Bibliographically approved
Buckland, G., Travier, N., Huerta, J. M., Bueno-de-Mesquita, H. B., Siersema, P. D., Skeie, G., . . . Gonzalez, C. A. (2015). Healthy lifestyle index and risk of gastric adenocarcinoma in the EPIC cohort study. International Journal of Cancer, 137(3), 598-606
Open this publication in new window or tab >>Healthy lifestyle index and risk of gastric adenocarcinoma in the EPIC cohort study
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2015 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 137, no 3, p. 598-606Article in journal (Refereed) Published
Abstract [en]

Several modifiable lifestyle factors, including smoking, alcohol, certain dietary factors and weight are independently associated with gastric cancer (GC); however, their combined impact on GC risk is unknown. We constructed a healthy lifestyle index to investigate the joint influence of these behaviors on GC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The analysis included 461,550 participants (662 first incident GC cases) with a mean follow-up of 11.4 years. A healthy lifestyle index was constructed, assigning 1 point for each healthy behavior related to smoking status, alcohol consumption and diet quality (represented by the Mediterranean diet) for assessing overall GC and also body mass index for cardia GC and 0 points otherwise. Risk of GC was calculated using Cox proportional hazards regression models while adjusting for relevant confounders. The highest versus lowest score in the healthy lifestyle index was associated with a significant lower risk of GC, by 51% overall (HR 0.49 95% CI 0.35, 0.70), by 77% for cardia GC (HR 0.23 95% CI 0.08, 0.68) and by 47% for noncardia GC (HR 0.53 (95% CI 0.32, 0.87), p-trends<0.001. Population attributable risk calculations showed that 18.8% of all GC and 62.4% of cardia GC cases could have been prevented if participants in this population had followed the healthy lifestyle behaviors of this index. Adopting several healthy lifestyle behaviors including not smoking, limiting alcohol consumption, eating a healthy diet and maintaining a normal weight is associated with a large decreased risk of GC. What's new? Several modifiable lifestyle factors, including smoking status, alcohol consumption, diet quality and weight, have been independently associated with gastric cancer. Behavioral patterns often cluster, however, lifestyle scores can be used to analyse overlapping risk factors. In this study, the authors used a healthy-lifestyle index to evaluate the combined effects of all of the above factors on the risk of developing gastric cancer (GC). They found that following a healthy lifestyle dramatically decreases the burden of gastric cancer.

Keywords
healthy lifestyle score, gastric cancer, cohort, EPIC
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-106111 (URN)10.1002/ijc.29411 (DOI)000354639200012 ()25557932 (PubMedID)
Available from: 2015-07-14 Created: 2015-07-09 Last updated: 2018-06-07Bibliographically approved
Zamora-Ros, R., Luján-Barroso, L., Bueno-de-Mesquita, H. B., Dik, V. K., Boeing, H., Steffen, A., . . . González, C. A. (2014). Tea and coffee consumption and risk of esophageal cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC) study. International Journal of Cancer, 135(6), 1470-1479
Open this publication in new window or tab >>Tea and coffee consumption and risk of esophageal cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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2014 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 135, no 6, p. 1470-1479Article in journal (Refereed) Published
Abstract [en]

Epidemiological data regarding tea and coffee consumption and risk of esophageal cancer (EC) is still inconclusive. We examined the association of tea and coffee consumption with EC risk among 442,143 men and women without cancer at baseline from 9 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). Tea and coffee intakes were recorded using country-specific validated dietary questionnaires. Cox regression models were used to analyze the relationships between tea and coffee intake and EC risk. During a mean follow-up of 11.1 years, 339 participants developed EC, of which 142 were esophageal adenocarcinoma (EAC) and 174 were esophageal squamous cell carcinoma (ESCC). In the multivariable models, no significant associations between tea (mostly black tea), and coffee intake and risk of EC, EAC and ESCC were observed. In stratified analyses, among men coffee consumption was inversely related to ESCC (HR for comparison of extreme tertiles 0.42, 95% CI 0.20-0.88; P-trend=0.022), but not among women. In current smokers, a significant and inverse association was observed between ESCC risk and tea (HR 0.46, 95% CI 0.23-0.93; P-trend=0.053) and coffee consumption (HR 0.37, 95% CI 0.19-0.73; P-trend=0.011). However, no statistically significant findings were observed using the continuous variable (per 100mL/d). These data did not show a significant association between tea and coffee consumption and EC, EAC and ESCC, although a decreased risk of ESCC among men and current smokers is suggested, but need to be confirmed in further prospective studies including more cases.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2014
Keywords
tea, coffee, esophageal cancer, smoking status, EPIC
National Category
Public Health, Global Health, Social Medicine and Epidemiology Nutrition and Dietetics Cancer and Oncology
Research subject
Nutrition; Public health
Identifiers
urn:nbn:se:umu:diva-86431 (URN)10.1002/ijc.28789 (DOI)000339269100020 ()24535727 (PubMedID)
Available from: 2014-02-26 Created: 2014-02-26 Last updated: 2018-06-08Bibliographically approved
Wallner, O. & Wallner, B. (2013). Balloon dilation of benign esophageal rings or strictures: a randomized clinical trial comparing two different inflation times. Diseases of the esophagus, 27(2), 109-111
Open this publication in new window or tab >>Balloon dilation of benign esophageal rings or strictures: a randomized clinical trial comparing two different inflation times
2013 (English)In: Diseases of the esophagus, ISSN 1120-8694, E-ISSN 1442-2050, Vol. 27, no 2, p. 109-111Article in journal (Refereed) Published
Abstract [en]

Although balloon dilatation is the primary treatment for benign dysphagia, information about the optimal inflation time is lacking. The aim of the current pilot study was to compare 10 seconds inflation time with 2 minutes inflation time, regarding the efficacy. Twenty patients with symptomatic strictures were prospectively studied in a randomized fashion. The 10-second group required an average of 1.4 dilations per patient; the 2-minute group required an average of 1.5 dilations per patient. This pilot study indicates that 10 seconds inflation time is as effective as 2 minutes. Because the treatment is both painful and unpleasant, this is an important finding.

Keywords
balloon dilation, benign esophageal stricture, esophagus
National Category
Surgery
Identifiers
urn:nbn:se:umu:diva-83659 (URN)10.1111/dote.12080 (DOI)000331129500002 ()23621385 (PubMedID)
Available from: 2013-12-03 Created: 2013-12-03 Last updated: 2018-06-08Bibliographically approved
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