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Bordas, Pal
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Publications (9 of 9) Show all publications
Barton, M., Santucci-Pereira, J., de Cicco, R. L., Russo, I. H., Ross, E. A., Slifker, M., . . . Russo, J. (2014). Long noncoding RNAs in the postmenopausal breast and their role in cancer prevention. Paper presented at 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), APR 05-09, 2014, San Diego, CA. Cancer Research, 74(19)
Open this publication in new window or tab >>Long noncoding RNAs in the postmenopausal breast and their role in cancer prevention
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2014 (English)In: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 74, no 19Article in journal, Meeting abstract (Other academic) Published
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-106386 (URN)10.1158/1538-7445.AM2014-1480 (DOI)000349906901209 ()
Conference
105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), APR 05-09, 2014, San Diego, CA
Note

Supplement: S, Meeting Abstract: 1480

Available from: 2015-07-14 Created: 2015-07-14 Last updated: 2018-08-31Bibliographically approved
Peri, S., de Cicco, R. L., Santucci-Pereira, J., Slifker, M., Ross, E. A., Russo, I. H., . . . Russo, J. (2012). Defining the genomic signature of the parous breast. BMC Medical Genomics, 5, 46
Open this publication in new window or tab >>Defining the genomic signature of the parous breast
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2012 (English)In: BMC Medical Genomics, ISSN 1755-8794, E-ISSN 1755-8794, Vol. 5, p. 46-Article in journal (Refereed) Published
Abstract [en]

Background: It is accepted that a woman's lifetime risk of developing breast cancer after menopause is reduced by early full term pregnancy and multiparity. This phenomenon is thought to be associated with the development and differentiation of the breast during pregnancy.

Methods: In order to understand the underlying molecular mechanisms of pregnancy induced breast cancer protection, we profiled and compared the transcriptomes of normal breast tissue biopsies from 71 parous (P) and 42 nulliparous (NP) healthy postmenopausal women using Affymetrix Human Genome U133 Plus 2.0 arrays. To validate the results, we performed real time PCR and immunohistochemistry.

Results: We identified 305 differentially expressed probesets (208 distinct genes). Of these, 267 probesets were up- and 38 down-regulated in parous breast samples; bioinformatics analysis using gene ontology enrichment revealed that up-regulated genes in the parous breast represented biological processes involving differentiation and development, anchoring of epithelial cells to the basement membrane, hemidesmosome and cell-substrate junction assembly, mRNA and RNA metabolic processes and RNA splicing machinery. The down-regulated genes represented biological processes that comprised cell proliferation, regulation of IGF-like growth factor receptor signaling, somatic stem cell maintenance, muscle cell differentiation and apoptosis.

Conclusions: This study suggests that the differentiation of the breast imprints a genomic signature that is centered in the mRNA processing reactome. These findings indicate that pregnancy may induce a safeguard mechanism at post-transcriptional level that maintains the fidelity of the transcriptional process.

Keywords
Gene expression profiling, Pregnancy, Breast morphology, Breast differentiation, Parous and nulliparous breast transcriptome, Breast cancer risk, Normal breast transcriptome, Bioinformatics
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-62168 (URN)10.1186/1755-8794-5-46 (DOI)000310854800001 ()
Available from: 2012-12-11 Created: 2012-12-10 Last updated: 2018-06-08Bibliographically approved
Hellquist Numan, B., Duffy, S. W., Abdsaleh, S., Björneld, L., Bordás, P., Tabár, L., . . . Jonsson, H. (2011). Effectiveness of population-based service screening with mammography for women ages 40 to 49 years: evaluation of the Swedish Mammography Screening in Young Women (SCRY) cohort. Cancer, 117(4), 714-722
Open this publication in new window or tab >>Effectiveness of population-based service screening with mammography for women ages 40 to 49 years: evaluation of the Swedish Mammography Screening in Young Women (SCRY) cohort
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2011 (English)In: Cancer, ISSN 0008-543X, E-ISSN 1097-0142, Vol. 117, no 4, p. 714-722Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The effectiveness of mammography screening for women ages 40 to 49 years still is questioned, and few studies of the effectiveness of service screening for this age group have been conducted.

METHODS: Breast cancer mortality was compared between women who were invited to service screening at ages 40 to 49 years (study group) and women in the same age group who were not invited during 1986 to 2005 (control group). Together, these women comprise the Mammography Screening of Young Women (SCRY) cohort, which includes all Swedish counties. A prescreening period was defined to facilitate a comparison of mortality in the absence of screening. The outcome measure was refined mortality, ie, breast cancer death for women who were diagnosed during follow-up at ages 40 to 49 years. Relative risks (RRs) with 95% confidence intervals (CIs) were estimated.

RESULTS: There was no significant difference in breast cancer mortality during the prescreening period. During the study period, there were 803 breast cancer deaths in the study group (7.3 million person-years) and 1238 breast cancer deaths in the control group (8.8 million person-years). The average follow-up was 16 years. The estimated RR for women who were invited to screening was 0.74 (95% CI, 0.66-0.83), and the RR for women who attended screening was 0.71 (95% CI, 0.62-0.80).

CONCLUSIONS: In this comprehensive study, mammography screening for women ages 40 to 49 years was efficient for reducing breast cancer mortality.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2011
Keywords
mammography, screening, breast cancer, mortality
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
urn:nbn:se:umu:diva-39340 (URN)10.1002/cncr.25650 (DOI)20882563 (PubMedID)
Available from: 2011-01-24 Created: 2011-01-24 Last updated: 2018-06-08Bibliographically approved
Bordás, P. (2010). Evaluation of the effectiveness of mammography screening in Northern Sweden.. (Doctoral dissertation). Umeå: Umeå universitet
Open this publication in new window or tab >>Evaluation of the effectiveness of mammography screening in Northern Sweden.
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Service screening with mammography was implemented in Northern Sweden between 1989 and 1998, covering 190,000 women aged 40-74 years constituting the target population in the area.

The aim of this thesis was the evaluation of mammography screening in Northern Sweden with special focus on selected screening performance indicators and on the disease outcome.

We analysed interval cancer (IC) incidence and episode sensitivity in the Norrbotten Mammography Screening Programme (NMSP) for the period 1989-2002. An overall IC rate at 1.1/1000 and IC rate ratio at 38% was found and epsiode sensitivity was estimated at 62-73%, in concert with reference values of the European guidelines.

Radiological classification of the IC cases in three rounds of the NMSP showed that true, occult, missed and minimal signs IC, were present in 48%, 10%, 14% and 28% of the cases.

We analysed early death from breast cancer (n=342) in Northern Sweden during the first five years of mammography service screening. Most fatal cases were advanced and incurable on diagnosis. In a few screen-detected cases with favourable prognostic factors the fatal outcome was unexpected.

We estimated breast cancer survival by detection mode in 5120 women with breast cancer. We found a significantly favourable survival among IC cases compared to cases among uninvited.

We studied breast cancer mortality in relation to mammography screening. Our findings indicated a long-term reduction of breast cancer mortality by 26-30% among women invited to screening and by 31-35% among women screened compared to not screened.

We conclude from our evaluation of the mammography screening in Northern Sweden that women benefited from this public health intervention in form of improved survival and reduced mortality.

Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2010. p. 61
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 1364
Keywords
mammography, screening, sensitivity, interval cancer, survival, mortality
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
urn:nbn:se:umu:diva-36141 (URN)978-91-7459-048-7 (ISBN)
Public defence
2010-10-15, Aulan, Sunderby sjukhus, Luleå, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2010-09-24 Created: 2010-09-20 Last updated: 2018-06-08Bibliographically approved
Bordás, P., Jonsson, H., Nyström, L. & Lenner, P. (2009). Interval cancer incidence and episode sensitivity in the Norrbotten mammography screening programme, Sweden. Journal of Medical Screening, 16(1), 39-45
Open this publication in new window or tab >>Interval cancer incidence and episode sensitivity in the Norrbotten mammography screening programme, Sweden
2009 (English)In: Journal of Medical Screening, ISSN 0969-1413, E-ISSN 1475-5793, Vol. 16, no 1, p. 39-45Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To estimate the interval cancer incidence, its determinants and the episode sensitivity in the Norrbotten Mammography Screening Programme (NMSP).

SETTING: Since 1989, women aged 40-74 years (n = 55,000) have been invited to biennial screening by the NMSP, Norrbotten county, Sweden.

METHODS: Data on 1047 invasive breast cancers from six screening rounds of the NMSP (1989-2002) were collected. We estimated the invasive interval cancer rates, rate ratios and the episode sensitivity using the detection and incidence methods. A linear Poisson-model was used to analyse association between interval cancer incidence and sensitivity.

RESULTS: 768 screen-detected and 279 interval cancer cases were identified. The rate ratio of interval cancer decreased with age. The 50-59 year age group showed the highest rate ratio (RR = 0.52, 95% CI 0.41-0.65) and the 70-74 year age group the lowest (RR = 0.23, 95% CI 0.15-0.36). The rate ratios for the early (0-12 months) and late (13-24 months) interval cancers were similar (RR = 0.18, 95% CI 0.15-0.22 and 0.20, 95% CI 0.17-0.24). There was a significantly lower interval cancer incidence in the prevalence round as compared with the incidence rounds. According to the detection method the episode sensitivity increased with age from 57% in the age group 40-49 years to 84% in the age group 70-74 years. The corresponding figures for the incidence method were 50% and 77%, respectively.

CONCLUSION: Our study showed an interval cancer incidence of 38% and the episode sensitivity of 62-73%, depending on the method of calculation. Our results are of clinically acceptable level and concert with the reference values of the European guidelines.

National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
urn:nbn:se:umu:diva-21722 (URN)10.1258/jms.2009.008098 (DOI)19349530 (PubMedID)
Available from: 2009-04-17 Created: 2009-04-17 Last updated: 2018-06-08Bibliographically approved
Jonsson, H., Bordás, P., Wallin, H., Nyström, L. & Lenner, P. (2007). Service screening with mammography in Northern Sweden: effects on breast cancer mortality - an update.. Journal of Medical Screening, 14(2), 87-93
Open this publication in new window or tab >>Service screening with mammography in Northern Sweden: effects on breast cancer mortality - an update.
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2007 (English)In: Journal of Medical Screening, ISSN 0969-1413, E-ISSN 1475-5793, Vol. 14, no 2, p. 87-93Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To study the effectiveness of service screening with mammography in Northern Sweden.

SETTING: Two counties which invited women aged 40-74 years to service screening with mammography were compared with two counties where service screening started 5-7 years later. There were 109,000 and 77,000 women in the study and control counties, respectively.

METHODS: Cohorts in the study group were defined to include only breast cancer cases diagnosed after their first invitation to screening. Two outcome measures for breast cancer mortality were used; excess mortality and underlying cause of death (UCD). Detection mode was used to estimate the efficacy of screening for those women who actually attended screening. The cohorts were followed for 11 years.

RESULTS: The relative rate (RR) of breast cancer death as excess mortality and UCD for women aged 40-74 years invited to screening, compared with women not yet invited, was 0.70 (95% confidence interval [CI] 0.56-0.87) and 0.74 (95% CI 0.62-0.88), respectively. The largest effect was seen in women aged 40-49 years (RR = 0.64 and RR = 0.62 for excess mortality and UCD, respectively). RR in age 40-74 years for women actually screened was 0.65 (95% CI 0.51-0.84) and 0.70 (95% CI 0.57-0.86) for excess mortality and UCD, respectively. The number of women needed to screen to save one life was 912 after 11 years of follow-up.

CONCLUSIONS: This study confirms previous findings in the earlier follow-up and indicates a long-term reduction of breast cancer mortality by 26-30%. The efficacy among those who actually attended screening was about 5% larger.

National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
urn:nbn:se:umu:diva-16185 (URN)10.1258/096914107781261918 (DOI)17626708 (PubMedID)
Available from: 2007-10-04 Created: 2007-10-04 Last updated: 2018-06-09Bibliographically approved
Bordás, P., Jonsson, H., Nyström, L. & Lenner, P. (2007). Survival from invasive breast cancer among interval cases in the mammography screening programmes of northern Sweden. Breast, 16(1), 47-54
Open this publication in new window or tab >>Survival from invasive breast cancer among interval cases in the mammography screening programmes of northern Sweden
2007 (English)In: Breast, ISSN 0960-9776, E-ISSN 1532-3080, Vol. 16, no 1, p. 47-54Article in journal (Refereed) Published
Keywords
mammography screening, invasive breast cancer, breast cancer survival, interval cases, uninvited cases, detection mode
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
urn:nbn:se:umu:diva-12232 (URN)10.1016/j.breast/2006.05.006 (DOI)16875820 (PubMedID)
Available from: 2007-08-28 Created: 2007-08-28 Last updated: 2018-06-09Bibliographically approved
Bordás, P., Jonsson, H., Nyström, L., Cajander, S. & Lenner, P. (2004). Early breast cancer deaths in women aged 40-74 years diagnosed during the first 5 years of organised mammography service screening in north Sweden. Breast, 13(4), 276-283
Open this publication in new window or tab >>Early breast cancer deaths in women aged 40-74 years diagnosed during the first 5 years of organised mammography service screening in north Sweden
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2004 (English)In: Breast, ISSN 0960-9776, E-ISSN 1532-3080, Vol. 13, no 4, p. 276-283Article in journal (Refereed) Published
Keywords
Breast cancer deaths, mammography, organised service screening
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
urn:nbn:se:umu:diva-14999 (URN)10.106/j.breast.2004.04.002 (DOI)15325661 (PubMedID)
Available from: 2007-05-08 Created: 2007-05-08 Last updated: 2018-06-09Bibliographically approved
Bordás, P., Jonsson, H., Nyström, L., Péntek, Z. & Lenner, P.Radiological review of interval cancer in the Norrbotten mammography screening program, Sweden.
Open this publication in new window or tab >>Radiological review of interval cancer in the Norrbotten mammography screening program, Sweden
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(English)Manuscript (preprint) (Other academic)
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
urn:nbn:se:umu:diva-35305 (URN)
Available from: 2010-08-12 Created: 2010-08-12 Last updated: 2018-06-08Bibliographically approved
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