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Rydh, Anders
Publications (10 of 15) Show all publications
Wixner, J., Karling, P., Rydh, A., Hornsten, R., Wiklund, U., Anan, I. & Suhr, O. B. (2012). Gastric emptying in hereditary transthyretin amyloidosis: the impact of autonomic neuropathy. Neurogastroenterology and Motility, 24(12), 1111-e568
Open this publication in new window or tab >>Gastric emptying in hereditary transthyretin amyloidosis: the impact of autonomic neuropathy
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2012 (English)In: Neurogastroenterology and Motility, ISSN 1350-1925, E-ISSN 1365-2982, Vol. 24, no 12, p. 1111-e568Article in journal (Refereed) Published
Abstract [en]

Background: Gastrointestinal (GI) complications are common in hereditary transthyretin amyloidosis and an autonomic dysfunction has been considered to explain these symptoms. The aim of this study was to investigate the impact of autonomic neuropathy on gastric emptying in hereditary transthyretin amyloidosis and to relate these findings to nutritional status, GI symptoms, gender, and age at disease onset.

Methods: Gastric emptying was evaluated with gastric emptying scintigraphy. Spectral analysis of the heart rate variability and cardiovascular responses after tilt test were used to assess the autonomic function. The nutritional status was evaluated with the modified body mass index (s-albumine x BMI).

Key Results: Gastric retention was found in about one-third of the patients. A weak correlation was found between the scintigraphic gastric emptying rate and both the sympathetic (rs = -0.397, P < 0.001) and parasympathetic function (rs = -0.282, P = 0.002). The gastric emptying rate was slower in those with lower or both upper and lower GI symptoms compared with those without symptoms (median T50 123 vs 113 min, P = 0.042 and 192 vs 113 min, P = 0.003, respectively). Multiple logistic regression analysis showed that age of onset (OR 0.10, CI 0.020.52) and sympathetic dysfunction (OR 0.23, CI 0.100.51), but not gender (OR 0.76, CI 0.311.84) and parasympathetic dysfunction (OR 1.81, CI 0.724.56), contributed to gastric retention.

Conclusions and Inferences: Gastric retention is common in hereditary transthyretin amyloidosis early after onset. Autonomic neuropathy only weakly correlates with gastric retention and therefore additional factors must be involved.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2012
Keywords
amyloidosis, autonomic nervous system disorders, gastric emptying, hereditary, nutrition status, transthyretin
National Category
Gastroenterology and Hepatology Neurosciences
Identifiers
urn:nbn:se:umu:diva-63020 (URN)10.1111/j.1365-2982.2012.01991.x (DOI)000311565300014 ()
Available from: 2012-12-28 Created: 2012-12-27 Last updated: 2018-06-08Bibliographically approved
Gradmark, A. M., Rydh, A., Renström, F., De Lucia-Rolfe, E., Sleigh, A., Nordström, P., . . . Franks, P. W. (2010). Computed tomography-based validation of abdominal adiposity measurements from ultrasonography, dual-energy X-ray absorptiometry and anthropometry. British Journal of Nutrition, 104(4), 582-588
Open this publication in new window or tab >>Computed tomography-based validation of abdominal adiposity measurements from ultrasonography, dual-energy X-ray absorptiometry and anthropometry
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2010 (English)In: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 104, no 4, p. 582-588Article in journal (Refereed) Published
Abstract [en]

Large-scale aetiological studies of obesity and its pathological consequences require accurate measurements of adipose mass, distribution and subtype. Here, we compared the validity of three abdominal obesity assessment methods (dual-energy X-ray absorptiometry (DXA), ultrasound and anthropometry) against the gold-standard method of computed tomography (CT) in twenty-nine non-diseased middle-aged men (BMI 26.5 (sd 3.1) kg/m(2)) and women (BMI 25.5 (sd 3.2) kg/m(2)). Assessments of adipose mass (kg) and distribution (total subcutaneous (TSAT), superficial subcutaneous (SSAT), deep subcutaneous (DSAT) and visceral (VAT)) were obtained. Spearman's correlations were performed adjusted for age and sex. VAT area that was assessed using ultrasound (r 0.79; P < 0.0001) and waist circumference (r 0.85; P < 0.0001) correlated highly with VAT from CT, as did BMI (r 0.67; P < 0.0001) and DXA (r 0.70; P < 0.0001). DXA (r 0.72; P = 0.0004), BMI (r 0.71; P = 0.0003), waist circumference (r 0.86; P < 0.0001) and ultrasound (r 0.52; P = 0.015) were less strongly correlated with CT TSAT. None of the comparison measures of DSAT was strongly correlated with CT DSAT (all r approximately 0.50; P < 0.02). BMI (r 0.76; P < 0.0001), waist circumference (r 0.65; P = 0.002) and DXA (r 0.75; P < 0.0001) were all fairly strongly correlated with the CT measure of SSAT, whereas ultrasound yielded a weaker yet statistically significant correlation (r 0.48; P = 0.03). Compared with CT, visceral and subcutaneous adiposity can be assessed with reasonable validity using waist circumference and BMI, respectively. Ultrasound or DXA does not generally provide substantially better measures of these traits. Highly valid assessments of DSAT do not appear to be possible with surrogate measures. These findings may help guide the selection of measures for epidemiological studies of obesity.

Keywords
Computed tomography, Ultrasound, Waist circumference, Waist:height ratio, Dual-energy X-ray absorptiometry, Obesity, Adipose tissue, Validation
Identifiers
urn:nbn:se:umu:diva-35681 (URN)10.1017/S0007114510000796 (DOI)20370942 (PubMedID)
Available from: 2010-08-31 Created: 2010-08-31 Last updated: 2018-06-08Bibliographically approved
Blomberg, F., Brulin, C., Andertun, R. & Rydh, A. (2010). Patients' perception of quality of care in a radiology department: a medical-physical approach. Journal of Radiology Nursing, 29(1), 10-17
Open this publication in new window or tab >>Patients' perception of quality of care in a radiology department: a medical-physical approach
2010 (English)In: Journal of Radiology Nursing, ISSN 1546-0843, Vol. 29, no 1, p. 10-17Article in journal (Refereed) Published
Abstract [en]

The aim of our cross-sectional study was to identify patients' perception of quality of care (QoC), and further to evaluate the relation between QoC and demographic factors in patients who have been subject to a radiology examination or a radiology treatment. Good QoC is the primary aim of the public medical and health service, with the aim of same quality for the whole population. Few scientific studies have been carried out within radiology with the aim of investigating differences between varying demographic factors and patient's perceptions of QoC. The radiology department's version of the Quality from the Patient's Perspective questionnaire (QPP) was used for data collection. Six hundred and ninty-eight patients participated in the study. Low estimation of the QoC was associated with dissatisfaction with telephone contact, long waiting time, neither easy nor hard waiting time experience, not receiving an invitation in time, and age 56 to 75 years. Female patient responses for estimated QoC were higher, as were those from patients with less formal education. Our study shows that factors inducing dissatisfaction concerning QoC, above all long waiting times, can be tolerated if radiology personnel provide good routines for information. Telephone contact, and adequate, timely information, is especially important. The results of this study demonstrate that several factors play a role in a patient's perception of QoC in a radiology department. The further research on patient-focused quality improvement is needed to improve patient's perception of quality care in the radiology department.

Keywords
quality of care, patients' experience, quantitative approaches, patient's perspective questionnaire (QPP)
Identifiers
urn:nbn:se:umu:diva-34643 (URN)10.1016/j.jradnu.2009.09.001 (DOI)
Available from: 2010-06-10 Created: 2010-06-10 Last updated: 2018-06-08Bibliographically approved
Kriström, B., Zdunek, A.-M., Rydh, A., Jonsson, H., Sehlin, P. & Andersson Escher, S. (2009). A novel mutation in the LIM homeobox 3 gene is responsible for combined pituitary hormone deficiency, hearing impairment, and vertebral malformations.. Journal of Clinical Endocrinology and Metabolism, 94(4), 1154-1161
Open this publication in new window or tab >>A novel mutation in the LIM homeobox 3 gene is responsible for combined pituitary hormone deficiency, hearing impairment, and vertebral malformations.
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2009 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 94, no 4, p. 1154-1161Article in journal (Refereed) Published
Abstract [en]

CONTEXT: The LIM homeobox 3 (LHX3) LIM-homeodomain transcription factor gene, found in both man and mouse, is required for development of the pituitary and motor neurons, and is also expressed in the auditory system. OBJECTIVE: The objective of this study was to determine the cause of, and further explore, the phenotype in six patients (aged 6 months to 22 yr) with combined pituitary hormone deficiency (CPHD), restricted neck rotation, scoliosis, and congenital hearing impairment. Three of the patients also have mild autistic-like behavior. DESIGN: Because patients with CPHD and restricted neck rotation have previously been shown to have mutations in the LHX3 gene, a candidate gene approach was applied, and the gene was sequenced. Neck anatomy was explored by computed tomography and magnetic resonance imaging, including three-dimensional reformatting. RESULTS: A novel, recessive, splice-acceptor site mutation was found. The predicted protein encoded by the mutated gene lacks the homeodomain and carboxyl terminus of the normal, functional protein. Genealogical studies revealed a common gene source for all six families dating back to the 17th century. Anatomical abnormalities in the occipito-atlantoaxial joints in combination with a basilar impression of the dens axis were found in all patients assessed. CONCLUSIONS: This study extends both the mutations known to be responsible for LHX3-associated syndromes and their possible phenotypical consequences. Previously reported traits include CPHD and restricted neck rotation; patients examined in the present study also show a severe hearing defect. In addition, the existence of cervical vertebral malformations are revealed, responsible for the rigid neck and the development of scoliosis.

Keywords
Hormone Deficiency, Hearing Impairment, Vertebral Malformations
National Category
Medical and Health Sciences
Research subject
Pediatrics
Identifiers
urn:nbn:se:umu:diva-34983 (URN)10.1210/jc.2008-0325 (DOI)19126629 (PubMedID)
Available from: 2010-06-29 Created: 2010-06-29 Last updated: 2019-04-01Bibliographically approved
Stensdotter, A.-K., Andersson, P.-I., Rydh, A. & Häger-Ross, C. (2009). Q-angle variations in standing and supine positions and for different measurement methods in women with and without patellofemoral pain. Advances in Physiotherapy, 11(2), 88-96
Open this publication in new window or tab >>Q-angle variations in standing and supine positions and for different measurement methods in women with and without patellofemoral pain
2009 (English)In: Advances in Physiotherapy, ISSN 1403-8196, E-ISSN 1651-1948, Vol. 11, no 2, p. 88-96Article in journal (Refereed) Published
Keywords
Goniometry, kinematics, positions, quadriceps angle, radiography
National Category
Physiotherapy
Research subject
Physiotherapy
Identifiers
urn:nbn:se:umu:diva-23334 (URN)10.1080/14038190802585485 (DOI)
Available from: 2009-06-11 Created: 2009-06-11 Last updated: 2018-06-08Bibliographically approved
Johansson, E., Rydh, A. & Åhlström Riklund, K. (2007). Ultrasound, Computed Tomography, and Laboratory Findings in the Diagnosis of Appendicitis. Acta Radiologica, 48(3), 267-273
Open this publication in new window or tab >>Ultrasound, Computed Tomography, and Laboratory Findings in the Diagnosis of Appendicitis
2007 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 48, no 3, p. 267-273Article in journal (Refereed) Published
Abstract [en]

Purpose: To determine the diagnostic accuracy and the clinical impact of ultrasound (US) and computed tomography (CT) in diagnosing appendicitis, and to evaluate the impact of laboratory tests on the treatment of acute appendicitis.

Material and Methods: All patients who, during 2005, underwent an acute ultrasound or CT investigation due to suspected appendicitis, or were diagnosed and/or surgically treated for appendicitis at Umeå University Hospital, Umeå, were included. The type of radiological investigation, its findings, the choice of treatment, final diagnosis, C-reactive protein (CRP), leukocyte particle count (LPC), body temperature, age, and sex were recorded for each patient. The histological result from surgery was considered the gold standard.

Results: The material included 305 cases with an overall appendicitis prevalence of 58%. Fifty-two percent of the patients were female. The mean age was 29 years, with a total range of 2–94 years. Twenty percent (60/305) underwent a CT investigation, 40% (123/305) underwent an US investigation, 5% (14/305) underwent both a CT and an US investigation, and 35% (108/305) of patients did not undergo any radiological investigation at all. The sensitivities and specificities were 91% and 94% for CT, and 83% and 98% for US, respectively. The positive likelihood ratio was 15.1 and 45.5 for CT and US, and the negative likelihood ratio was 0.09 and 0.18 for CT and US, respectively. It was not possible to visualize the appendix in 31% of patients examined with US. The prevalence of appendicitis in this group was the same as the prevalence among patients where it was possible to see the appendix, i.e., 35%. The mean CRP for all patients with appendicitis was 59 (95% CI 10–491) mg/l, and the mean LPC was 11.1 (95% CI 2.6–28.1) ×10−9/l. The mean LPC level was significantly higher for the appendicitis patients. Body temperature could not significantly verify or exclude appendicitis. The overall negative appendectomy rate was 9% (16/176), and it was higher in women, i.e., 11% (9/79). The negative appendectomy rate was slightly higher in the group that was examined by CT and/or US, i.e., 12% (8/69) compared to 7% (8/107) in the group not examined radiologically.

Conclusion: Diagnostic accuracy was high for US as well as for CT. US was better for diagnosing positive findings, while CT was better for excluding diagnosis of appendicitis. The diagnostic accuracy of LPC, CRP, and body temperature was low. By combining findings from the radiological examination with the results from the clinical examination and laboratory values, a low negative appendectomy rate can be achieved.

Keywords
Abdomen/GI, appendix, CT, inflammation, surgery, ultrasound
National Category
Clinical Medicine
Identifiers
urn:nbn:se:umu:diva-106084 (URN)10.1080/02841850601182162 (DOI)
Available from: 2015-07-07 Created: 2015-07-07 Last updated: 2018-06-07Bibliographically approved
Arheden, H., Aspelin, P., Bajc, M., Damm, S., Flodmark, O., Friberg, P., . . . Rydh, A. (2006). Functional imaging medicine: a new specialty with great prospects. Läkartidningen, 103(39), 2883-2884
Open this publication in new window or tab >>Functional imaging medicine: a new specialty with great prospects
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2006 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 103, no 39, p. 2883-2884Article in journal (Refereed) Published
Identifiers
urn:nbn:se:umu:diva-30088 (URN)17128923 (PubMedID)
Available from: 2009-12-03 Created: 2009-12-03 Last updated: 2018-06-08
Suhr, O. B., Anan, I., Åhlström Riklund, K. & Rydh, A. (2003). Gastric emptying before and after liver transplantation for familial amyloidotic polyneuropathy, Portuguese type (Val30Met).. Amyloid: Journal of Protein Folding Disorders, 10(2), 121-6
Open this publication in new window or tab >>Gastric emptying before and after liver transplantation for familial amyloidotic polyneuropathy, Portuguese type (Val30Met).
2003 (English)In: Amyloid: Journal of Protein Folding Disorders, ISSN 1350-6129, E-ISSN 1744-2818, Vol. 10, no 2, p. 121-6Article in journal (Refereed) Published
Abstract [en]

Liver transplantation is an accepted treatment of familial amyloidotic polyneuropathy (FAP), Portuguese type (Val30Met), and the outcome so far seems promising. Gastric retention with nausea and vomiting are common complications of the disease, and may interfere with immuno-suppression therapy and prolong recovery after liver transplantation. The aim of this study was to assess the frequency of gastric retention in FAP patients and to evaluate the impact liver transplantation has on gastric emptying. Twenty-two patients, who had undergone liver transplantation, and had been re-examined for gastric retention after the procedure, were included in the study. Gastric emptying was recorded by scintigraphy after the ingestion of a 99m-technetium (99mTc)-labelled meal (omelette). The half-time (T50) of the emptying phase was calculated. Gastrointestinal symptoms before and after transplantation were recorded, and the majority of patients were also subjected to an upper endoscopic examination, where the presence of solid residual in the stomach was regarded as consistent with gastric retention. A high frequency of gastric retention was noted among the patients both before and after transplantation, and no significant improvement for the group was noted, even though decreased gastric emptying was noted for patients with a duration of the disease for less that 4 years. Patients who improved their nutritional status after transplantation had a faster gastric emptying than those who deteriorated. From our findings it can be concluded that gastric retention is a common complication of FAP and that gastric emptying in patients with longstanding disease (> or = 4 years) is unchanged after liver transplantation.

Identifiers
urn:nbn:se:umu:diva-30097 (URN)12964420 (PubMedID)
Available from: 2009-12-04 Created: 2009-12-04 Last updated: 2018-06-08
Rydh, A., Åhlström Riklund, K., Sperens, U. & Boquist, S. (2003). [Internet-supported education in medical radiology at the university in Umea. Digital radiology has reached the students]. Läkartidningen, 100(42), 3320-1
Open this publication in new window or tab >>[Internet-supported education in medical radiology at the university in Umea. Digital radiology has reached the students]
2003 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 100, no 42, p. 3320-1Article in journal (Refereed) Published
Identifiers
urn:nbn:se:umu:diva-30095 (URN)14619043 (PubMedID)
Available from: 2009-12-04 Created: 2009-12-04 Last updated: 2018-06-08
Rydh, A., Lundblad, M., Åhlström Riklund, K., Tavelin, B. & Stattin, P. (2003). MRI of the skeleton in prostate cancer staging.. Scandinavian Journal of Urology and Nephrology, 37(3), 222-5
Open this publication in new window or tab >>MRI of the skeleton in prostate cancer staging.
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2003 (English)In: Scandinavian Journal of Urology and Nephrology, ISSN 0036-5599, E-ISSN 1651-2065, Vol. 37, no 3, p. 222-5Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To explore the value of MRI in the detection of bone metastases in newly diagnosed prostate cancer. MATERIAL AND METHODS: MRI examinations of the axial skeleton in 76 patients with newly diagnosed prostate cancer were reviewed, and the relation of these findings to the serum level of prostate specific antigen (PSA) was examined. RESULTS: MRI indicated bone metastases in 26/76 patients (34%) in the entire study group, in 4/24 (17%) with serum PSA <20 ng/ml and in 22/52 (42%) with serum PSA >20 ng/ml. CONCLUSIONS: These results suggest that MRI is a more sensitive indicator of suspected bone metastases than bone scintigraphy in the low range of serum PSA, but less sensitive in the high range. Further studies of MRI and bone scintigraphy in parallel in patients with serum PSA <20 ng/ml are needed to elucidate their relative value in the staging of patients with prostate cancer.

Identifiers
urn:nbn:se:umu:diva-30094 (URN)12775281 (PubMedID)
Available from: 2009-12-04 Created: 2009-12-04 Last updated: 2018-06-08
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