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Loutfi, Ghada
Publications (3 of 3) Show all publications
Loutfi, G., Linder, J., Hariz, G.-M., Hariz, M. & Blomstedt, P. (2014). Pallidal Deep Brain Stimulation in the Treatment of Huntington’s Chorea. Brain Disorders & Therapy, 3(4)
Open this publication in new window or tab >>Pallidal Deep Brain Stimulation in the Treatment of Huntington’s Chorea
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2014 (English)In: Brain Disorders & Therapy, ISSN 2168-975X, Vol. 3, no 4Article in journal (Refereed) Published
Abstract [en]

Despite the success of deep brain stimulation (DBS) in various movement disorders, its use in Huntington´s Disease (HD) has been limited. So far, promising results of pallidal DBS have been reported in 7 patients with HD. We performed bilateral pallidal DBS in a 59 year old woman with HD since 12 years and severe motor symptoms. At the evaluation after 12 months the effect was deemed satisfactory mainly concerning the patient’s choreatic symptoms. However, the improvement according to the unified Huntington’s disease rating scale was modest, with a score reduction from 92 to 81.

Keywords
DBS, Huntington's chorea, Pallidum
National Category
Neurology
Research subject
Neurosurgery
Identifiers
urn:nbn:se:umu:diva-105932 (URN)10.4172/2168-975X.1000136 (DOI)
Available from: 2015-07-01 Created: 2015-07-01 Last updated: 2018-06-07Bibliographically approved
Loutfi, G., Blomstedt, P., Linder, J. & Hariz, M. (2014). Pallidal deep brain stimulation in the treatment of Huntington's chorea. Paper presented at Joint Congress of European Neurology, MAY 31-JUN 03, 2014, Istanbul, TURKEY. European Journal of Neurology, 21, 125-125
Open this publication in new window or tab >>Pallidal deep brain stimulation in the treatment of Huntington's chorea
2014 (English)In: European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331, Vol. 21, p. 125-125Article in journal, Meeting abstract (Other academic) Published
National Category
Neurology
Identifiers
urn:nbn:se:umu:diva-91218 (URN)000337563600240 ()
Conference
Joint Congress of European Neurology, MAY 31-JUN 03, 2014, Istanbul, TURKEY
Available from: 2014-07-21 Created: 2014-07-21 Last updated: 2018-06-07Bibliographically approved
Lundin, A., Dietrichs, E., Haghighi, S., Göller, M.-L., Heiberg, A., Loutfi, G., . . . Tedroff, J. (2010). Efficacy and safety of the dopaminergic stabilizer Pridopidine (ACR16) in patients with Huntington's disease. Clinical neuropharmacology, 33(5), 260-264
Open this publication in new window or tab >>Efficacy and safety of the dopaminergic stabilizer Pridopidine (ACR16) in patients with Huntington's disease
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2010 (English)In: Clinical neuropharmacology, ISSN 0362-5664, E-ISSN 1537-162X, Vol. 33, no 5, p. 260-264Article in journal (Refereed) Published
Abstract [en]

Pridopidine shows promise as a treatment for some of the symptoms of HD. In this small-scale study, the most notable effect was improvement in voluntary motor symptoms. Larger, longer-term trials are warranted.

Keywords
ACR16, dopaminergic stabilizer, Huntington's disease, pridopidine, randomized clinical trial
Identifiers
urn:nbn:se:umu:diva-42294 (URN)10.1097/WNF.0b013e3181ebb285 (DOI)20616707 (PubMedID)
Available from: 2011-04-07 Created: 2011-04-07 Last updated: 2018-06-08Bibliographically approved
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