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BETA
Lundskog, Bertil
Alternative names
Publications (9 of 9) Show all publications
Fallah, M., Shen, Y., Brodén, J., Bäckman, A., Lundskog, B., Johansson, M., . . . Ny, T. (2018). Plasminogen activation is required for the development of radiation-induced dermatitis. Cell Death and Disease, 9(11), Article ID 1051.
Open this publication in new window or tab >>Plasminogen activation is required for the development of radiation-induced dermatitis
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2018 (English)In: Cell Death and Disease, ISSN 2041-4889, E-ISSN 2041-4889, Vol. 9, no 11, article id 1051Article in journal (Refereed) Published
Abstract [en]

Skin damage caused by radiation therapy (radiodermatitis) is a severe side effect of radiotherapy in cancer patients, and there is currently a lack of effective strategies to prevent or treat such skin damage. In this work, we show with several lines of evidence that plasminogen, a pro-inflammatory factor, is key for the development of radiodermatitis. After skin irradiation in wild type (plg+/+) mice, the plasminogen level increased in the radiated area, leading to severe skin damage such as ulcer formation. However, plasminogen-deficient (plg−/−) mice and mice lacking plasminogen activators were mostly resistant to radiodermatitis. Moreover, treatment with a plasminogen inhibitor, tranexamic acid, decreased radiodermatitis in plg+/+ mice and prevented radiodermatitis in plg+/ mice. Together with studies at the molecular level, we report that plasmin is required for the induction of inflammation after irradiation that leads to radiodermatitis, and we propose that inhibition of plasminogen activation can be a novel treatment strategy to reduce and prevent the occurrence of radiodermatitis in patients.

 

 

Place, publisher, year, edition, pages
Springer, 2018
Keywords
Inflammation, plasminogen, radiation-induced dermatitis
National Category
Cell and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-152950 (URN)10.1038/s41419-018-1106-8 (DOI)000447324600005 ()30323258 (PubMedID)
Available from: 2018-10-31 Created: 2018-10-31 Last updated: 2018-11-01Bibliographically approved
Jahns, A. C., Lundskog, B., Nosek, D., Killasli, H., Emtestam, L. & Alexeyev, O. A. (2015). Microbiology of folliculitis decalvans: a histological study of 37 patients [Letter to the editor]. Journal of the European Academy of Dermatology and Venereology, 29(5), 1025-1026
Open this publication in new window or tab >>Microbiology of folliculitis decalvans: a histological study of 37 patients
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2015 (English)In: Journal of the European Academy of Dermatology and Venereology, ISSN 0926-9959, E-ISSN 1468-3083, Vol. 29, no 5, p. 1025-1026Article in journal, Letter (Other academic) Published
National Category
Dermatology and Venereal Diseases
Identifiers
urn:nbn:se:umu:diva-103187 (URN)10.1111/jdv.12448 (DOI)000353457100033 ()24629101 (PubMedID)
Available from: 2015-05-29 Created: 2015-05-18 Last updated: 2018-06-07Bibliographically approved
Jahns, A., Killasli, H., Nosek, D., Lundskog, B., Lenngren, A., Muratova, Z., . . . Alexeyev, O. (2014). Microbiology of hidradenitis suppurativa (acne inversa): a histological study of 27 patients. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 122(9), 804-809
Open this publication in new window or tab >>Microbiology of hidradenitis suppurativa (acne inversa): a histological study of 27 patients
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2014 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 122, no 9, p. 804-809Article in journal (Refereed) Published
Abstract [en]

Hidradenitis suppurativa (acne inverse) (HS) is a chronic skin disease primarily affecting hair follicles. The aetiology of HS is unknown, but infection is believed to play some role. This retrospective study investigated the microbial colonization directly in skin appendices in HS skin samples. Archival samples from 27 patients with HS were screened by immunofluorescence labelling with monoclonal and polyclonal antibodies against Gram-positive bacteria, Propionibacterium acnes and Propionibacterium granulosum. Fluorescence in situ hybridization was used for further species identification of Staphylococcus spp. Overall, 17 patients (63%) were found positive for bacterial colonization. Of these, 15 showed colonization in hair follicles and/or sinus tracts. The most commonly identified bacteria were DAPI labelled coccoids that were seen in 71% of the positive patients in the form of biofilms and microcolonies. P. acnes was found as biofilms in hair follicles of two patients. Staphylococcus aureus and coagulase-negative staphylococci were not detected in any sample. The results of this study indicate a common bacterial presence in HS skin lesions. Bacterial biofilms are not uncommon and their pathogenic role needs further evaluation.

Keywords
Hidradenitis, Propionibacterium acnes, Staphylococcus, biofilm, in situ hybridization
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-93822 (URN)10.1111/apm.12220 (DOI)000341151300012 ()24475943 (PubMedID)
Available from: 2014-10-08 Created: 2014-10-01 Last updated: 2018-06-07Bibliographically approved
Bodén, I., Nyström, J., Lundskog, B., Zazo, V., Geladi, P., Lindholm-Sethson, B. & Naredi, P. (2013). Non-invasive identification of melanoma with near-infrared and skin impedance spectroscopy. Skin research and technology, 19(1), e473-e478
Open this publication in new window or tab >>Non-invasive identification of melanoma with near-infrared and skin impedance spectroscopy
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2013 (English)In: Skin research and technology, ISSN 0909-752X, E-ISSN 1600-0846, Vol. 19, no 1, p. e473-e478Article in journal (Refereed) Published
Abstract [en]

Background/purpose: An early diagnosis of cutaneous malignant melanoma is of high importance for good prognosis. An objective, non-invasive instrument could improve the diagnostic accuracy of melanoma and decrease unnecessary biopsies. The aim of this study was to investigate the use of Near infrared and skin impedance spectroscopy in combination as a tool to distinguish between malignant and benign skin tumours.

Methods: Near infrared and skin impedance spectra were collected in vivo on 50 naevi or suspect melanomas prior to excision. Received data was analysed with multivariate techniques and the results were compared to histopathology analyses of the tumours. A total of 12 cutaneous malignant melanomas, 19 dysplastic naevi and 19 benign naevi were included in the study.

Results: The observed sensitivity and specificity of the proposed method were 83% and 95%, respectively, for malignant melanoma.

Conclusions: The results indicate that the combination of near infrared and skin impedance spectroscopy is a promising tool for non-invasive diagnosis of suspect cutaneous malignant melanomas. 

Place, publisher, year, edition, pages
John Wiley & Sons, 2013
Keywords
NIR, PLS-DA classification, combination probe, skin cancer, in vivo
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:umu:diva-50452 (URN)10.1111/j.1600-0846.2012.00668.x (DOI)000313258100061 ()22958059 (PubMedID)
Available from: 2011-12-09 Created: 2011-12-09 Last updated: 2018-06-08Bibliographically approved
Jahns, A. C., Lundskog, B., Ganceviciene, R., Palmer, R. H., Golovleva, I., Zouboulis, C. C., . . . Alexeyev, O. A. (2012). An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study. British Journal of Dermatology, 167(1), 50-58
Open this publication in new window or tab >>An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study
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2012 (English)In: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133, Vol. 167, no 1, p. 50-58Article in journal (Refereed) Published
Abstract [en]

Summary Background  Acne vulgaris is a disorder of the sebaceous follicles. Propionibacterium acnes can be involved in inflammatory acne. Objectives  This case-control study aimed at investigating the occurrence and localization of P. acnes in facial biopsies in acne and to characterize the P. acnes phylotype in skin compartments. Methods  Specific monoclonal and polyclonal antibodies were applied to skin biopsies of 38 patients with acne and matching controls to localize and characterize P. acnes and to determine expression of co-haemolysin CAMP factor, a putative virulence determinant. Results  Follicular P. acnes was demonstrated in 18 (47%) samples from patients with acne and eight (21%) control samples [odds ratio (OR) 3·37, 95% confidence interval (CI) 1·23-9·23; P = 0·017]. In 14 (37%) samples from patients with acne, P. acnes was visualized in large macrocolonies/biofilms in sebaceous follicles compared with only five (13%) control samples (OR 3·85, 95% CI 1·22-12·14; P = 0·021). Macrocolonies/biofilms consisting of mixed P. acnes phylotypes expressing CAMP1 were detected in both case and control samples. Only four samples tested positive for the presence of Staphylococcus spp. and fungi were not observed. Conclusions  We have for the first time visualized different P. acnes phylotypes in macrocolonies/biofilms in sebaceous follicles of skin biopsies. Our results support the hypothesis that P. acnes can play a role in the pathogenesis of acne as acne samples showed a higher prevalence of follicular P. acnes colonization, both in terms of follicles containing P. acnes and the greater numbers of bacteria in macrocolonies/biofilms than in control samples.

National Category
Dermatology and Venereal Diseases
Identifiers
urn:nbn:se:umu:diva-56937 (URN)10.1111/j.1365-2133.2012.10897.x (DOI)000305791500011 ()22356121 (PubMedID)
Available from: 2012-07-02 Created: 2012-06-29 Last updated: 2018-06-08Bibliographically approved
Jahns, A. C., Lundskog, B., Dahlberg, I., Tamayo, N. C., Mcdowell, A., Patrick, S. & Alexeyev, O. A. (2012). No link between rosacea and Propionibacterium acnes. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 120(11), 922-925
Open this publication in new window or tab >>No link between rosacea and Propionibacterium acnes
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2012 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 120, no 11, p. 922-925Article in journal (Refereed) Published
Abstract [en]

Rosacea is a common skin disease in adults affecting mainly the facial skin. Although inflammation appears to play a pathogenic role in rosacea, initiating factors are largely unknown. Microbial involvement in the development of rosacea has been suggested previously. We aimed to visualize Propionibacterium acnes in the skin compartments of rosacea patients. Facial skin biopsies from 82 rosacea patients and 25 controls were stained with a P. acnes-specific monoclonal antibody (QUBPa3). Seven of 82 patients (8.5%) tested positive for P. acnes which was present either as a biofilm (57% of positive) or a microcolony (43%) in colonized patients. Our results suggest that P. acnes does not play a major role in the pathogenesis of rosacea.

Keywords
Propionibacterium acnes, rosacea, immunofluorescence, biofilm, granuloma
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-61150 (URN)10.1111/j.1600-0463.2012.02920.x (DOI)000309182900007 ()
Available from: 2012-11-15 Created: 2012-11-07 Last updated: 2018-06-08Bibliographically approved
Alexeyev, O. A., Lundskog, B., Ganceviciene, R., Palmer, R. H., McDowell, A., Patrick, S., . . . Golovleva, I. (2012). Pattern of tissue invasion by Propionibacterium acnes in acne vulgaris [Letter to the editor]. Journal of dermatological science (Amsterdam), 67(1), 63-66
Open this publication in new window or tab >>Pattern of tissue invasion by Propionibacterium acnes in acne vulgaris
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2012 (English)In: Journal of dermatological science (Amsterdam), ISSN 0923-1811, E-ISSN 1873-569X, Vol. 67, no 1, p. 63-66Article in journal, Letter (Refereed) Published
National Category
Dermatology and Venereal Diseases
Identifiers
urn:nbn:se:umu:diva-56936 (URN)10.1016/j.jdermsci.2012.03.004 (DOI)000306047700010 ()22510385 (PubMedID)
Available from: 2012-07-02 Created: 2012-06-29 Last updated: 2018-06-08Bibliographically approved
Mahdavi, J., Sondén, B., Hurtig, M., Olfat, F. O., Forsberg, L., Roche, N., . . . Borén, T. (2002). Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science, 297(5581), 573-578
Open this publication in new window or tab >>Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation
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2002 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 297, no 5581, p. 573-578Article in journal (Refereed) Published
Abstract [en]

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.

Place, publisher, year, edition, pages
American Association for the Advancement of Science, 2002
National Category
Medical and Health Sciences Microbiology in the medical area Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
urn:nbn:se:umu:diva-4319 (URN)10.1126/science.1069076 (DOI)000177054200042 ()12142529 (PubMedID)
Available from: 2004-12-21 Created: 2004-12-21 Last updated: 2019-01-23Bibliographically approved
Fallah, M., Viklund, E., Shen, Y., Bäckman, A., Lundskog, B., Johansson, M., . . . Ny, T.Plasminogen enhances the healing of radiation-induced wounds via decreased expression of pro-inflammatory and pro-fibrotic factors.
Open this publication in new window or tab >>Plasminogen enhances the healing of radiation-induced wounds via decreased expression of pro-inflammatory and pro-fibrotic factors
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(English)Manuscript (preprint) (Other academic)
National Category
Cancer and Oncology Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-152951 (URN)
Available from: 2018-10-31 Created: 2018-10-31 Last updated: 2018-11-01
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