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Jalkanen, Ville
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Publications (10 of 38) Show all publications
Åstrand, A., Andersson, B., Jalkanen, V., Börje, L., Anders, B. & Lindahl, O. (2017). Prostate cancer detection with a tactile resonance sensor: measurement considerations and clinical setup. Sensors, 17(11), Article ID 2453.
Open this publication in new window or tab >>Prostate cancer detection with a tactile resonance sensor: measurement considerations and clinical setup
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2017 (English)In: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 17, no 11, article id 2453Article in journal (Refereed) Published
Abstract [en]

Tumors in the human prostate are usually stiffer compared to surrounding non-malignant glandular tissue, and tactile resonance sensors measuring stiffness can be used to detect prostate cancer. To explore this further, we used a tactile resonance sensor system combined with a rotatable sample holder where whole surgically removed prostates could be attached to detect tumors on, and beneath, the surface ex vivo. Model studies on tissue phantoms made of silicone and porcine tissue were performed. Finally, two resected human prostate glands were studied. Embedded stiff silicone inclusions placed 4 mm under the surface could be detected in both the silicone and biological tissue models, with a sensor indentation of 0.6 mm. Areas with different amounts of prostate cancer (PCa) could be distinguished from normal tissue (p < 0.05), when the tumor was located in the anterior part, whereas small tumors located in the dorsal aspect were undetected. The study indicates that PCa may be detected in a whole resected prostate with an uneven surface and through its capsule. This is promising for the development of a clinically useful instrument to detect prostate cancer during surgery.

Place, publisher, year, edition, pages
Switzerland: MDPI AG, 2017
Keywords
tissue stiffness, resonance sensor, tactile sensor, prostate cancer, piezoelectric sensor
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:umu:diva-141158 (URN)10.3390/s17112453 (DOI)000416790500015 ()
Available from: 2017-10-26 Created: 2017-10-26 Last updated: 2018-06-09Bibliographically approved
Nyberg, M., Jalkanen, V., Ramser, K., Ljungberg, B., Bergh, A. & Lindahl, O. A. (2015). Dual-modality probe intended for prostate cancer detection combining Raman spectroscopy and tactile resonance technology—discrimination of normal human prostate tissues ex vivo. Journal of Medical Engineering & Technology, 39(3), 198-207
Open this publication in new window or tab >>Dual-modality probe intended for prostate cancer detection combining Raman spectroscopy and tactile resonance technology—discrimination of normal human prostate tissues ex vivo
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2015 (English)In: Journal of Medical Engineering & Technology, ISSN 0309-1902, E-ISSN 1464-522X, Vol. 39, no 3, p. 198-207Article in journal (Refereed) Published
Abstract [en]

Prostate cancer is the most common cancer for men in the western world. For the first time, a dual-modality probe, combining Raman spectroscopy and tactile resonance technology, has been used for assessment of fresh human prostate tissue. The study investigates the potential of the dual-modality probe by testing its ability to differentiate prostate tissue types ex vivo. Measurements on four prostates show that the tactile resonance modality was able to discriminate soft epithelial tissue and stiff stroma (p<0.05). The Raman spectra exhibited a strong fluorescent background at the current experimental settings. However, stroma could be discerned from epithelia by integrating the value of the spectral background. Combining both parameters by a stepwise analysis resulted in 100% sensitivity and 91% specificity. Although no cancer tissue was analysed, the results are promising for further development of the instrument and method for discriminating prostate tissues and cancer.

Place, publisher, year, edition, pages
Taylor & Francis, 2015
Keywords
Prostate cancer, radical prostatectomy, raman spectroscopy, tactile resonance technology, tissue autofluorescence
National Category
Medical Engineering Medical Laboratory and Measurements Technologies Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-103285 (URN)10.3109/03091902.2015.1021430 (DOI)
Available from: 2015-05-19 Created: 2015-05-19 Last updated: 2018-06-07Bibliographically approved
Åstrand, A. P., Andersson, B. M., Jalkanen, V. & Lindahl, O. A. (2015). Initial Measurements on Whole Human Prostate ex vivo with a Tactile Resonance Sensor in Order to Detect Prostate Cancer. In: Henrik Mindedal, Mikael Persson (Ed.), 16th Nordic-Baltic Conference on Biomedical Engineering: 16. NBC & 10. MTD 2014 joint conferences. October 14-16, 2014, Gothenburg, Sweden. Paper presented at 16th Nordic-Baltic Conference on Biomedical Engineering October 14-16, 2014, Gothenburg, Sweden (pp. 120-123). Springer International Publishing
Open this publication in new window or tab >>Initial Measurements on Whole Human Prostate ex vivo with a Tactile Resonance Sensor in Order to Detect Prostate Cancer
2015 (English)In: 16th Nordic-Baltic Conference on Biomedical Engineering: 16. NBC & 10. MTD 2014 joint conferences. October 14-16, 2014, Gothenburg, Sweden / [ed] Henrik Mindedal, Mikael Persson, Springer International Publishing , 2015, p. 120-123Conference paper, Published paper (Refereed)
Abstract [en]

Prostate cancer (PCa) is the most common form of cancer among the male population in Europe and the USA. PCa can be suspected by a blood test for a specific prostate antigen, a PSA-test, followed by a digital rectal examination (DRE). The objective with the DRE is to investigate the presence of stiff nodules on the prostate. Stiff nodules can indicate PCa and biopsies are taken from the suspicious parts of the prostate using guidance of a transrectal ultrasound. Microscopic evaluation of the biopsies is used for final diagnosis. Superficial tumor growth on, and beneath the surface of the gland is of special interest as it suggests that the cancer has spread to other parts of the body.

Tactile resonance sensors can be used to distinguish between areas of different stiffness in soft tissue. The aim was to detect tumors on, and beneath the surface of a whole human prostate ex vivo.

A tactile resonance sensor system (TRSS) based on a piezoelectric resonance sensor and a force sensor has been used to detect areas with increased stiffness in soft tissue. The TRSS has a rotatable sample holder for measurements on spherical shaped samples. Stiffness measurements were made on samples of porcine muscle tissue with embedded stiff silicone nodules placed under the surface. Further measurements were made on a resected whole human prostate with PCa.

The results showed that through the measured stiffness parameter, the stiff silicone nodules placed down to 4 mm under the surface could be detected. The measurements on the prostate showed that elevated values of the stiffness parameter correlated (p < 0.05) with areas in the anterior of the prostate where cancer tumors were detected by histopathological evaluation. The tumors were significantly stiffer than the healthy tissue in the dorsal region.

The results are promising for further development of a clinically useful instrument to detect superficial PCa.

Place, publisher, year, edition, pages
Springer International Publishing, 2015
Series
IFMBE Proceedings, ISSN 1680-0737 ; 48
Keywords
Prostate cancer, Tissue stiffness, Resonance sensors
National Category
Medical Engineering Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:umu:diva-97279 (URN)10.1007/978-3-319-12967-9_33 (DOI)000347893000033 ()978-3-319-12966-2 (ISBN)978-3-319-12967-9 (ISBN)
Conference
16th Nordic-Baltic Conference on Biomedical Engineering October 14-16, 2014, Gothenburg, Sweden
Available from: 2014-12-12 Created: 2014-12-12 Last updated: 2018-06-07Bibliographically approved
Lindahl, O. A., Nyberg, M., Jalkanen, V. & Ramser, K. (2015). Prostate cancer detection using a combination of Raman spectroscopy and stiffness sensing. In: Fong-Chin Su, Shyh-Hau Wang, Ming-Long Yeh (Ed.), 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering: October 9-12, 2014, Tainan, Taiwan. Paper presented at 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering, October 9-12, 2014, Tainan, Taiwan (pp. 267-270). Springer International Publishing
Open this publication in new window or tab >>Prostate cancer detection using a combination of Raman spectroscopy and stiffness sensing
2015 (English)In: 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering: October 9-12, 2014, Tainan, Taiwan / [ed] Fong-Chin Su, Shyh-Hau Wang, Ming-Long Yeh, Springer International Publishing , 2015, p. 267-270Conference paper, Published paper (Refereed)
Abstract [en]

Prostate cancer (PCa) is the most common cancer form for men in Europe. A sensor system combining Raman spectroscopy and stiffness sensing with a resonance sensor has recently been developed by us for prostate cancer detection. In this study the sensor system has been used for measurements on two slices of fresh human prostate tissue. The stiffness sensor could detect locations slices with significantly different stiffness contrasts (p < 0.05). Raman spectroscopic measurements could be performed with the dual-modality probe for tissue classification. The findings are important for the continued development of a combination probe for prostate cancer detection.

Place, publisher, year, edition, pages
Springer International Publishing, 2015
Series
IFMBE Proceedings, ISSN 1680-0737 ; 47
Keywords
Fiber optical Raman spectroscopy, tactile resonance sensor technology, histopathology, prostate cancer detection, radical
National Category
Medical Engineering Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:umu:diva-97278 (URN)10.1007/978-3-319-12262-5_74 (DOI)000349915800074 ()978-3-319-12261-8 (ISBN)978-3-319-12262-5 (ISBN)
Conference
1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering, October 9-12, 2014, Tainan, Taiwan
Available from: 2014-12-12 Created: 2014-12-12 Last updated: 2018-06-07Bibliographically approved
Nyberg, M., Jalkanen, V., Ramser, K., Ljungberg, B., Bergh, A. & Lindahl, O. A. (2014). First study on freshly operated prostate tissue using a combination of Raman spectroscopy and tactile resonance sensor technology. In: Medicinteknikdagarna 2014: Göteborg, 14-16 oktober, 2014. Paper presented at 16. NBC & 10. MTD 2014 joint conferences. October 14-16, 2014, Gothenburg, Sweden (pp. 26-26).
Open this publication in new window or tab >>First study on freshly operated prostate tissue using a combination of Raman spectroscopy and tactile resonance sensor technology
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2014 (English)In: Medicinteknikdagarna 2014: Göteborg, 14-16 oktober, 2014, 2014, p. 26-26Conference paper, Oral presentation with published abstract (Refereed)
National Category
Medical Engineering Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:umu:diva-97281 (URN)
Conference
16. NBC & 10. MTD 2014 joint conferences. October 14-16, 2014, Gothenburg, Sweden
Available from: 2014-12-12 Created: 2014-12-12 Last updated: 2018-06-07Bibliographically approved
Åstrand, A., Jalkanen, V., Andersson, B. M. & Lindahl, O. A. (2013). Contact angle and indentation velocity dependency for a resonance sensor: Evaluation on soft tissue silicone models. Journal of Medical Engineering & Technology, 37(3), 185-196
Open this publication in new window or tab >>Contact angle and indentation velocity dependency for a resonance sensor: Evaluation on soft tissue silicone models
2013 (English)In: Journal of Medical Engineering & Technology, ISSN 0309-1902, E-ISSN 1464-522X, Vol. 37, no 3, p. 185-196Article in journal (Refereed) Published
Abstract [en]

Human tissue stiffness can vary due to different tissue conditions such as cancer tumours. Earlier studies show that stiffness may be detected with a resonance sensor that measures frequency shift and contact force at application. Through the frequency shift and the contact force, a tissue stiffness parameter can be derived. This study evaluated how the probe application angle and indentation velocity affected the results and determined the maximum parameter errors. The evaluation was made on flat silicone discs with specified hardness. The frequency shift, the force and the stiffness parameter all varied with contact angle and indentation velocity. A contact angle of ≤10° was acceptable for reliable measurements. A low indentation velocity was recommended. The maximum errors for the system were <1.1% of the measured values. It was concluded that contact angle and indentation velocity have to be considered in the clinical setting. The angular dependency is especially important in clinical use for studying stiffness of human soft tissue, e.g. in prostate cancer diagnosis.

Place, publisher, year, edition, pages
Informa Healthcare, 2013
Keywords
Contact angle, Frequency shift, Indentation velocity, Resonance sensor, Tissue stiffness
National Category
Medical Engineering
Identifiers
urn:nbn:se:umu:diva-68970 (URN)10.3109/03091902.2013.773097 (DOI)
Available from: 2013-05-02 Created: 2013-05-02 Last updated: 2018-06-08Bibliographically approved
Nyberg, M., Ville, J., Bergh, A., Ramser, K. & Lindahl, O. A. (2013). First clinical study of prostate cancer detection with a dual sensor combining tactile resonance technique with fiber optical Raman spectroscopy. In: 9th Workshop on FT-IR Spectroscopy in Microbiological and Medical Diagnostics: . Paper presented at 9th Workshop on FT-IR Spectroscopy in Microbiological and Medical Diagnostics, Robert Koch-Institute, Berlin, October 24-25, 2013.
Open this publication in new window or tab >>First clinical study of prostate cancer detection with a dual sensor combining tactile resonance technique with fiber optical Raman spectroscopy
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2013 (English)In: 9th Workshop on FT-IR Spectroscopy in Microbiological and Medical Diagnostics, 2013Conference paper, Poster (with or without abstract) (Refereed)
National Category
Medical Engineering Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:umu:diva-82937 (URN)
Conference
9th Workshop on FT-IR Spectroscopy in Microbiological and Medical Diagnostics, Robert Koch-Institute, Berlin, October 24-25, 2013
Available from: 2013-11-13 Created: 2013-11-13 Last updated: 2018-06-08Bibliographically approved
Jalkanen, V., Andersson, B., Bergh, A., Ljungberg, B. & Lindahl, O. (2013). Indentation loading response of a resonance sensor: discriminating prostate cancer and normal tissue. Journal of Medical Engineering & Technology, 37(7), 416-423
Open this publication in new window or tab >>Indentation loading response of a resonance sensor: discriminating prostate cancer and normal tissue
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2013 (English)In: Journal of Medical Engineering & Technology, ISSN 0309-1902, E-ISSN 1464-522X, Vol. 37, no 7, p. 416-423Article in journal (Refereed) Published
Abstract [en]

Prostate cancer is the most common type of cancer among men worldwide. Mechanical properties of prostate tissue are promising for distinguishing prostate cancer from healthy prostate tissue. The aim was to investigate the indentation loading response of a resonance sensor for discriminating prostate cancer tissue from normal tissue. Indentation measurements were done on prostate tissue specimens ex vivo from 10 patients from radical prostatectomy. The measurement areas were analysed using standard histological methods. The stiffness parameter was linearly dependent on the loading force (average R2 = 0.90) and an increased loading force caused a greater stiffness contrast of prostate cancer vs normal tissue. The accuracy of the stiffness contrast was assessed by the ROC curve with the area under the curve being 0.941 for a loading force of 12.8 mN. The results are promising for the development of a resonance sensor instrument for detecting prostate cancer.

Place, publisher, year, edition, pages
Taylor & Francis, 2013
Keywords
Indentation, loading, prostate cancer, resonance sensor, stiffness
National Category
Medical Engineering Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:umu:diva-79947 (URN)10.3109/03091902.2013.824510 (DOI)
Available from: 2013-09-04 Created: 2013-09-04 Last updated: 2018-06-08Bibliographically approved
Pålsson, J., Jalkanen, V., Holmgren, U. & Bränberg, A. (2013). PBL för att stötta professionsfärdigheter. In: : . Paper presented at Den 11:e Universitetspedagogiska konferensen vid Umeå universitet 13-14 mars 2013. Umeå: Umeå universitet
Open this publication in new window or tab >>PBL för att stötta professionsfärdigheter
2013 (Swedish)Conference paper, Oral presentation with published abstract (Refereed)
Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2013
National Category
Pedagogy Other Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
urn:nbn:se:umu:diva-67495 (URN)
Conference
Den 11:e Universitetspedagogiska konferensen vid Umeå universitet 13-14 mars 2013
Available from: 2013-03-21 Created: 2013-03-21 Last updated: 2018-06-08Bibliographically approved
Åstrand, A., Jalkanen, V., Andersson, B. & Lindahl, O. A. (2013). Stiffness measurements on spherical surfaces of prostate models using a resonance sensor. In: Mian Long (Ed.), World Congress on Medical Physics and Biomedical Engineering May 26-31, 2012, Beijing, China: . Paper presented at WC2012 World Congress on Medical Physics and Biomedical Engineering, Beijing, China, May 26-31, 2012 (pp. 1401-1404). Springer Berlin/Heidelberg
Open this publication in new window or tab >>Stiffness measurements on spherical surfaces of prostate models using a resonance sensor
2013 (English)In: World Congress on Medical Physics and Biomedical Engineering May 26-31, 2012, Beijing, China / [ed] Mian Long, Springer Berlin/Heidelberg, 2013, p. 1401-1404Conference paper, Published paper (Refereed)
Abstract [en]

Prostate cancer is one of the most common formsof cancer among men in Europe and the United States.Piezoelectric resonance sensors can be used in medicalresearch for measurements of stiffness of human tissue.Cancer tissue is usually stiffer and has different biomechanicalproperties compared to healthy tissue. The frequency shiftobserved when a piezoelectric resonance sensor comes intocontact with a tissue surface has been suggested to correlatewith the stiffness variations, e.g. due to cancer. An instrumenthas been developed, with which it is possible to scan flat andspherical objects and where the sensor can be tilted fordifferent contact angles. Measurements performed in thisstudy on spherical tissue models made of silicone, showed theimportance of keeping the contact angle perpendicular to thesurface of the sphere. The results are promising for futurestudies on prostate tissue to complete the evaluation of theinstrument.

Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2013
Series
IFMBE Proceedings, ISSN 1680-0737 ; 39
Keywords
Resonance sensor, Piezoelectric, Prostate cancer, Detection, Frequency shift
National Category
Medical Engineering
Research subject
Electronics
Identifiers
urn:nbn:se:umu:diva-55888 (URN)10.1007/978-3-642-29305-4_368 (DOI)978-3-642-29304-7 (ISBN)978-3-642-29305-4 (ISBN)
Conference
WC2012 World Congress on Medical Physics and Biomedical Engineering, Beijing, China, May 26-31, 2012
Available from: 2012-06-08 Created: 2012-06-08 Last updated: 2018-06-08Bibliographically approved
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