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Burén, Jonas
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Publications (10 of 30) Show all publications
Blomquist, C., Alvehus, M., Burén, J., Ryberg, M., Larsson, C., Lindahl, B., . . . Olsson, T. (2017). Attenuated Low-Grade Inflammation Following Long-Term Dietary Intervention in Postmenopausal Women with Obesity. Obesity, 25(5), 892-900
Open this publication in new window or tab >>Attenuated Low-Grade Inflammation Following Long-Term Dietary Intervention in Postmenopausal Women with Obesity
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2017 (English)In: Obesity, ISSN 1930-7381, E-ISSN 1930-739X, Vol. 25, no 5, p. 892-900Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Abdominal fat accumulation after menopause is associated with low-grade inflammation and increased risk of metabolic disorders. Effective long-term lifestyle treatment is therefore needed.

METHODS: Seventy healthy postmenopausal women (age 60 ± 5.6 years) with BMI 32.5 ± 5.5 were randomized to a Paleolithic-type diet (PD) or a prudent control diet (CD) for 24 months. Blood samples and fat biopsies were collected at baseline, 6 months, and 24 months to analyze inflammation-related parameters.

RESULTS: Android fat decreased significantly more in the PD group (P = 0.009) during the first 6 months with weight maintenance at 24 months in both groups. Long-term significant effects (P < 0.001) on adipose gene expression were found for toll-like receptor 4 (decreased at 24 months) and macrophage migration inhibitory factor (increased at 24 months) in both groups. Serum interleukin 6 (IL-6) and tumor necrosis factor α levels were decreased at 24 months in both groups (P < 0.001) with a significant diet-by-time interaction for serum IL-6 (P = 0.022). High-sensitivity C-reactive protein was decreased in the PD group at 24 months (P = 0.001).

CONCLUSIONS: A reduction of abdominal obesity in postmenopausal women is linked to specific changes in inflammation-related adipose gene expression.

National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-134986 (URN)10.1002/oby.21815 (DOI)000400045000013 ()28440046 (PubMedID)
Funder
Swedish Research Council, K2011-12237-15-6
Available from: 2017-05-15 Created: 2017-05-15 Last updated: 2018-06-09Bibliographically approved
Boman, N., Burén, J., Antti, H. & Svensson, M. B. (2015). Gene expression and fiber type variations in repeated vastus lateralis biopsies. Muscle and Nerve, 52(2), 812-817
Open this publication in new window or tab >>Gene expression and fiber type variations in repeated vastus lateralis biopsies
2015 (English)In: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 52, no 2, p. 812-817Article in journal (Refereed) Published
Abstract [en]

Introduction: Muscle sample collection can introduce variation in any measured variable due to inter- and intramuscle variation. We investigated the variation in gene expression and fiber type composition after repeated biopsy sampling from the vastus lateralis muscle. Methods: Six subjects donated 3 tissue samples each. One hour after baseline sampling from 1 vastus lateralis muscle, samples from both vastus lateralis muscles were obtained. Results: The fiber type composition differed between biopsies taken from the same leg. There were no within-subject differences in gene expression between the 3 biopsies. Multivariate analysis supports a model in which gene expression differs significantly between individuals but is not affected by repeated muscle biopsy sampling from the same subject. Conclusion: One vastus lateralis muscle sample per subject is sufficient to establish a reliable baseline for comparing gene expression representing selected pathways over time within the same individual.

Keywords
fiber type, gene expression, human, muscle, repeated sampling
National Category
Physiology
Identifiers
urn:nbn:se:umu:diva-103248 (URN)10.1002/mus.24616 (DOI)000362549500017 ()25703336 (PubMedID)
Available from: 2015-05-19 Created: 2015-05-19 Last updated: 2018-06-07Bibliographically approved
Alvehus, M., Boman, N., Söderlund, K., Svensson, M. B. & Buren, J. (2014). Metabolic adaptations in skeletal muscle, adipose tissue, and whole-body oxidative capacity in response to resistance training. European Journal of Applied Physiology, 114(7), 1463-1471
Open this publication in new window or tab >>Metabolic adaptations in skeletal muscle, adipose tissue, and whole-body oxidative capacity in response to resistance training
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2014 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 114, no 7, p. 1463-1471Article in journal (Refereed) Published
Abstract [en]

The effects of resistance training on mitochondrial biogenesis and oxidative capacity in skeletal muscle are not fully characterized, and even less is known about alterations in adipose tissue. We aimed to investigate adaptations in oxidative metabolism in skeletal muscle and adipose tissue after 8 weeks of heavy resistance training in apparently healthy young men. Expression of genes linked to oxidative metabolism in the skeletal muscle and adipose tissue was assessed before and after the training program. Body composition, peak oxygen uptake (VO2 peak), fat oxidation, activity of mitochondrial enzyme in muscle, and serum adiponectin levels were also determined before and after resistance training. In muscle, the expression of the genes AdipoR1 and COX4 increased after resistance training (9 and 13 %, respectively), whereas the expression levels of the genes PGC-1 alpha, SIRT1, TFAM, CPT1b, and FNDC5 did not change. In adipose tissue, the expression of the genes SIRT1 and CPT1b decreased after training (20 and 23 %, respectively). There was an increase in lean mass (from 59.7 +/- A 6.1 to 61.9 +/- A 6.2 kg), VO2 peak (from 49.7 +/- A 5.5 to 56.3 +/- A 5.0 ml/kg/min), and fat oxidation (from 6.8 +/- A 2.1 to 9.1 +/- A 2.7 mg/kg fat-free mass/min) after training, whereas serum adiponectin levels decreased significantly and enzyme activity of citrate synthase and 3-hydroxyacyl-CoA dehydrogenase did not change. Despite significant increases in VO2 peak, fat oxidation, and lean mass following resistance training, the total effect on gene expression and enzyme activity linked to oxidative metabolism was moderate.

Keywords
Resistance training, Oxidative capacity, Skeletal muscle, Adipose tissue, Gene expression, Enzyme activity
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:umu:diva-91051 (URN)10.1007/s00421-014-2879-9 (DOI)000337052300013 ()
Available from: 2014-07-11 Created: 2014-07-10 Last updated: 2018-06-07Bibliographically approved
Ji, C., Dai, Y., Jiang, W., Liu, J., Hou, M., Wang, J., . . . Li, X. (2014). Postnatal overfeeding promotes early onset and exaggeration of high-fat diet-induced nonalcoholic fatty liver disease through disordered hepatic lipid metabolism in rats. Journal of Nutritional Biochemistry, 25(11), 1108-1116
Open this publication in new window or tab >>Postnatal overfeeding promotes early onset and exaggeration of high-fat diet-induced nonalcoholic fatty liver disease through disordered hepatic lipid metabolism in rats
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2014 (English)In: Journal of Nutritional Biochemistry, ISSN 0955-2863, E-ISSN 1873-4847, Vol. 25, no 11, p. 1108-1116Article in journal (Refereed) Published
Abstract [en]

Exposure to overnutrition in critical or sensitive developmental periods may increase the risk of developing obesity and metabolic syndrome in adults. Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome, but the relationship among postnatal nutrition, lipid metabolism, and NAFLD progression during development remains poorly understood. Here we investigated in a rat model whether postnatal overfeeding increases susceptibility to NAFLD in response to a high-fat diet. Litters from Sprague-Dawley dams were culled to three (small litters) or ten (normal litters) pups and then weaned onto a standard or high-fat diet at postnatal day 21 to generate normal-litter, small-litter, normal-litter/high-fat, and small-litter/high-fat groups. At age 16 weeks, the small-litter and both high-fat groups showed obesity, dyslipidemia, and insulin resistance. Hepatic disorders appeared earlier in the small-litter/high-fat rats with greater liver mass gain and higher hepatic triglycerides and steatosis score versus normal-litter/high-fat rats. Hepatic acetyl-CoA carboxylase activity and mRNA expression were increased in small-litter rats and aggravated in small-litter/high-fat rats but not in normal-litter/high-fat rats. The high expression in small-litter/high-fat rats coincided with high sterol regulatory element-binding protein-1c mRNA and protein expression. However, mRNA expression of enzymes involved in hepatic fatty acid oxidation (carnitine palmitoyltransferase 1) and output (microsomal triglyceride transfer protein) was decreased under a high-fat diet regardless of litter size. In conclusion, overfeeding related to small-litter rearing during lactation contributes to the NAFLD phenotype when combined with a high-fat diet, possibly through up-regulated hepatic lipogenesis. (C) 2014 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2014
Keywords
Early overfeeding, Liver, High-fat diet, Lipid metabolism, Nonalcoholic fatty liver disease, Rat
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-96948 (URN)10.1016/j.jnutbio.2014.06.010 (DOI)000344205600002 ()
Available from: 2015-01-12 Created: 2014-12-05 Last updated: 2018-06-07Bibliographically approved
Sjödin, A., Persson, S., Stigsson Claesson, M. & Burén, J. (2013). Motionärer och elit har samma koll på kosten. Svensk Idrottsforskning: Organ för Centrum för Idrottsforskning (4), 35-37
Open this publication in new window or tab >>Motionärer och elit har samma koll på kosten
2013 (Swedish)In: Svensk Idrottsforskning: Organ för Centrum för Idrottsforskning, ISSN 1103-4629, no 4, p. 35-37Article in journal (Other (popular science, discussion, etc.)) Published
Abstract [sv]

Elitspelare i innebandyns superliga har inte bättre kunskap än motionärer om vilka kostrekommendationer som gäller vid träning. Lägst kunskap har spelarna om kostens betydelse för uppladdningen. För att kunna prestera maximalt är det viktigt att kunna anpassa energi-, närings- och vätskeintag till sin idrott.

Place, publisher, year, edition, pages
Centrum för Idrottsforskning, 2013
Keywords
Idrottsnutrition, kost, uppladdning, innebandy, kunskap
National Category
Nutrition and Dietetics Sport and Fitness Sciences
Research subject
Food and Nutrition
Identifiers
urn:nbn:se:umu:diva-86508 (URN)
Available from: 2014-02-28 Created: 2014-02-28 Last updated: 2018-06-08Bibliographically approved
Alvehus, M., Simonyte, K., Andersson, T., Söderström, I., Burén, J., Rask, E., . . . Olsson, T. (2012). Adipose tissue IL-8 is increased in normal weight women after menopause and reduced after gastric bypass surgery in obese women. Clinical Endocrinology, 77(5), 684-690
Open this publication in new window or tab >>Adipose tissue IL-8 is increased in normal weight women after menopause and reduced after gastric bypass surgery in obese women
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2012 (English)In: Clinical Endocrinology, ISSN 0300-0664, E-ISSN 1365-2265, Vol. 77, no 5, p. 684-690Article in journal (Refereed) Published
Abstract [en]

Objective:  The menopausal transition is characterized by increased body fat accumulation, including redistribution from peripheral to central fat depots. This distribution is associated with an increased risk of type 2 diabetes and cardiovascular disease which are linked to low-grade inflammation. We determined whether postmenopausal women have higher levels of inflammatory markers, compared to premenopausal women. We also wanted to determine if these markers are reduced by stable weight loss in obese women. Design and methods:  Anthropometric data, blood samples, and subcutaneous adipose tissue biopsies were collected from normal weight premenopausal and postmenopausal women and obese women before and 2 years after gastric bypass surgery. Serum protein levels and adipose tissue gene expression of inflammatory markers were investigated. Results:  IL-8 expression in adipose tissue and circulating levels were higher in postmenopausal versus premenopausal women. IL-8 expression was associated with waist circumference, independent of menopausal status. IL-6 expression and serum levels of monocyte chemoattractant protein (MCP)-1 were higher in postmenopausal versus premenopausal women. Two years after gastric bypass surgery, adipose expression of IL-8, tumor necrosis factor-α, and MCP-1 decreased significantly. Serum insulin levels were associated with inflammation-related gene expression before gastric bypass surgery, but these associations disappeared after surgery. Conclusion:  Postmenopausal women have an increased inflammatory response in the subcutaneous fat and circulation. Inflammatory markers in adipose tissue decreased significantly after surgery-induced weight loss. This effect may be beneficial for metabolic control and reduced cardiovascular risk after weight loss. © 2011 Blackwell Publishing Ltd.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2012
Keywords
IL-8, menopause, gastric bypass surgery
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-51103 (URN)10.1111/j.1365-2265.2011.04322.x (DOI)22168600 (PubMedID)
Available from: 2012-01-10 Created: 2012-01-10 Last updated: 2018-06-08Bibliographically approved
Hou, M., Ji, C., Wang, J., Liu, Y., Sun, B., Guo, M., . . . Li, X. (2012). The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood: can omega 3 polyunsaturated fatty acids prevent adverse programming outcomes?. Journal of Endocrinology, 215(1), 119-127
Open this publication in new window or tab >>The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood: can omega 3 polyunsaturated fatty acids prevent adverse programming outcomes?
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2012 (English)In: Journal of Endocrinology, ISSN 0022-0795, E-ISSN 1479-6805, Vol. 215, no 1, p. 119-127Article in journal (Refereed) Published
Abstract [en]

Early life nutrition is important in the regulation of metabolism in adulthood. We studied the effects of different fatty acid composition diets on adiposity measures, glucose tolerance, and peripheral glucocorticoid (GC) metabolism in overfed neonatal rats. Rat litters were adjusted to a litter size of three (small litters (SLs)) or ten (normal litters (NLs)) on postnatal day 3 to induce overfeeding or normal feeding respectively. After weaning, SL and NL rats were fed a omega 6 polyunsaturated fatty acid (PUFA) diet (14% calories as fat, soybean oil) or high-saturated fatty acid (high-fat; 31% calories as fat, lard) diet until postnatal week 16 respectively. SL rats were also divided into the third group fed a omega 3 PUFA diet (14% calories as fat, fish oil). A high-fat diet induced earlier and/or more pronounced weight gain, hyperphagia, glucose intolerance, and hyperlipidemia in SL rats compared with NL rats. In addition, a high-fat diet increased 11 beta-hsd1 (Hsd11b1) mRNA expression and activity in the retroperitoneal adipose tissue of both litter groups compared with standard chow counterparts, whereas high-fat feeding increased hepatic 11 beta-hsd1 mRNA expression and activity only in SL rats. SL and a high-fat diet exhibited significant interactions in both retroperitoneal adipose tissue and hepatic 11 beta-HSD1 activity. Dietary omega 3 PUFA offered protection against glucose intolerance and elevated GC exposure in the retroperitoneal adipose tissue and liver of SL rats. Taken together, the results suggest that dietary fatty acid composition in the post-sucking period may interact with neonatal feeding and codetermine metabolic alterations in adulthood. Journal of Endocrinology (2012) 215, 119-127

National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-61179 (URN)10.1530/JOE-12-0191 (DOI)000309000000013 ()
Available from: 2012-11-09 Created: 2012-11-07 Last updated: 2018-06-08Bibliographically approved
Evans, J., Goedecke, J. H., Söderström, I., Burén, J., Alvehus, M., Blomquist, C., . . . Olsson, T. (2011). Depot- and ethnic-specific differences in the relationship between adipose tissue inflammation and insulin sensitivity. Clinical Endocrinology, 74(1), 51-59
Open this publication in new window or tab >>Depot- and ethnic-specific differences in the relationship between adipose tissue inflammation and insulin sensitivity
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2011 (English)In: Clinical Endocrinology, ISSN 0300-0664, E-ISSN 1365-2265, Vol. 74, no 1, p. 51-59Article in journal (Refereed) Published
Abstract [en]

Objective  It is unclear whether there are differences in inflammatory gene expression between abdominal and gluteal subcutaneous adipose tissue (SAT), and between black and white women. We therefore tested the hypotheses that SAT inflammatory gene expression is greater in the abdominal compared to the gluteal depot, and SAT inflammatory gene expression is associated with differential insulin sensitivity (S(I) ) in black and white women.

Design and methods  S(I) (frequently sampled intravenous glucose tolerance test) and abdominal SAT and gluteal SAT gene expression levels of 13 inflammatory genes were measured in normal-weight (BMI 18-25 kg/m(2) ) and obese (BMI >30 kg/m(2) ) black (n = 30) and white (n = 26) South African women.

Results  Black women had higher abdominal and gluteal SAT expression of CCL2, CD68, TNF-α and CSF-1 compared to white women (P < 0·01). Multivariate analysis showed that inflammatory gene expression in the white women explained 56·8% of the variance in S(I) (P < 0·005), compared to 20·9% in black women (P = 0·30). Gluteal SAT had lower expression of adiponectin, but higher expression of inflammatory cytokines, macrophage markers and leptin than abdominal SAT depots (P < 0·05).

Conclusions  Black South African women had higher inflammatory gene expression levels than white women; however, the relationship between AT inflammation and S(I) was stronger in white compared to black women. Further research is required to explore other factors affecting S(I) in black populations. Contrary to our original hypothesis, gluteal SAT had a greater inflammatory gene expression profile than abdominal SAT depots. The protective nature of gluteo-femoral fat therefore requires further investigation.

Identifiers
urn:nbn:se:umu:diva-38726 (URN)10.1111/j.1365-2265.2010.03883.x (DOI)20874774 (PubMedID)
Available from: 2010-12-23 Created: 2010-12-23 Last updated: 2018-06-08Bibliographically approved
Hou, M., Liu, Y., Zhu, L., Sun, B., Guo, M., Burén, J. & Li, X. (2011). Neonatal overfeeding induced by small litter rearing causes altered glucocorticoid metabolism in rats. PLoS ONE, 6(11), e25726
Open this publication in new window or tab >>Neonatal overfeeding induced by small litter rearing causes altered glucocorticoid metabolism in rats
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2011 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 6, no 11, p. e25726-Article in journal (Refereed) Published
Abstract [en]

Elevated glucocorticoid (GC) activity may be involved in the development of the metabolic syndrome. Tissue GC exposure is determined by the tissue-specific GC-activating enzyme 11 beta-hydroxysteriod dehydrogenase type 1 (11 beta-HSD1) and the GC-inactivating enzyme 5 alpha-reductase type 1 (5 alpha R1), as well as 5 beta-reductase (5 beta R). Our aim was to study the effects of neonatal overfeeding induced by small litter rearing on the expression of GC-regulating enzymes in adipose tissue and/or liver and on obesity-related metabolic disturbances during development. Male Sprague-Dawley rat pup litters were adjusted to litter sizes of three (small litters, SL) or ten (normal litters, NL) on postnatal day 3 and then given standard chow from postnatal week 3 onward (W3). Small litter rearing induced obesity, hyperinsulinemia, and higher circulating corticosterone in adults. 11 beta-HSD1 expression and enzyme activity in retroperitoneal, but not in epididymal, adipose tissue increased with postnatal time and peaked at W5/W6 in both groups before declining. From W8, 11 beta-HSD1 expression and enzyme activity levels in retroperitoneal fat persisted at significantly higher levels in SL compared to NL rats. Hepatic 11 beta-HSD1 enzyme activity in SL rats was elevated from W3 to W16 compared to NL rats. Hepatic 5 alpha R1 and 5 beta R expression was higher in SL compared to NL rats after weaning until W6, whereupon expression decreased in the SL rats and remained similar to that in NL rats. In conclusion, small litter rearing in rats induced peripheral tissue-specific alterations in 11 beta-HSD1 expression and activity and 5 alpha R1 and 5 beta R expression during puberty, which could contribute to elevated tissue-specific GC exposure and aggravate the development of metabolic dysregulation in adults.

Place, publisher, year, edition, pages
Public Library of Science, 2011
National Category
Biological Sciences
Identifiers
urn:nbn:se:umu:diva-50692 (URN)10.1371/journal.pone.0025726 (DOI)000297198200002 ()
Available from: 2011-12-20 Created: 2011-12-19 Last updated: 2018-06-08Bibliographically approved
Lindholm, Å., Blomquist, C., Bixo, M., Dahlbom, I., Hansson, T., Sundström Poromaa, I. & Burén, J. (2011). No difference in markers of adipose tissue inflammation between overweight women with polycystic ovary syndrome and weight-matched controls.. Human Reproduction, 26(6), 1478-85
Open this publication in new window or tab >>No difference in markers of adipose tissue inflammation between overweight women with polycystic ovary syndrome and weight-matched controls.
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2011 (English)In: Human Reproduction, ISSN 0268-1161, E-ISSN 1460-2350, Vol. 26, no 6, p. 1478-85Article in journal (Refereed) Published
Abstract [en]

UNLABELLED: BACKGROUND; Previous studies have indicated that peripheral circulating markers of inflammation are elevated in women with polycystic ovary syndrome (PCOS), but thus far no studies concerning markers of inflammation in adipose tissue have been published. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory markers in adipose tissue.

METHODS: Twenty overweight patients with PCOS, 10 lean patients with PCOS and 20 overweight controls had subcutaneous fat biopsies and blood samples taken. Adipose tissue levels of mRNA of inflammatory markers were determined by use of real-time PCR.

RESULTS: Overweight patients with PCOS had higher relative adipose tissue chemokine ligand 2 (P < 0.01), and its cognate receptor (P < 0.05), tumour necrosis factor-α (P < 0.001), interleukin (IL)-10 (P < 0.001) and IL-18 (P < 0.001) and the monocyte/macrophage markers CD14 (P < 0.01) and CD163 (P < 0.01) mRNA levels compared with lean women with PCOS. There were no differences between overweight patients with PCOS and overweight control subjects in this respect. Within the PCOS group, markers of adipose tissue inflammation correlated significantly with obesity-related metabolic disturbances, but when data were adjusted for age and BMI, most correlations were lost.

CONCLUSIONS: Overweight, rather than the PCOS diagnosis per se, appears to be the main explanatory variable for elevated adipose tissue inflammation in patients with PCOS.

Keywords
Cannabinoid; Middle cerebral artery occlusion; Ischaemia; Stroke; Receptor reserve; [35S]GTPγS autoradiography; CP55, 940
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:umu:diva-49386 (URN)10.1093/humrep/der096 (DOI)21478181 (PubMedID)
Available from: 2011-11-10 Created: 2011-11-10 Last updated: 2018-06-08Bibliographically approved
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