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Lundström, Nils-Göran
Alternative names
Publications (10 of 12) Show all publications
Rentschler, G., Rodushkin, I., Cerna, M., Chen, C., Harari, F., Harari, R., . . . Bergdahl, I. A. (2018). Platinum, palladium, rhodium, molybdenum and strontium in blood of urban women in nine countries. International journal of hygiene and environmental health (Print), 221(2), 223-230
Open this publication in new window or tab >>Platinum, palladium, rhodium, molybdenum and strontium in blood of urban women in nine countries
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2018 (English)In: International journal of hygiene and environmental health (Print), ISSN 1438-4639, E-ISSN 1618-131X, Vol. 221, no 2, p. 223-230Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: There is little reliable information on human exposure to the metals platinum (Pt), palladium (Pd) and rhodium (Rh), despite their use in enormous quantities in catalytic converters for automobile exhaust systems.

OBJECTIVES: To evaluate blood concentrations of Pt (B-Pt), Pd (B-Pd) and Rh (B-Rh) in women from six European and three non-European countries, and to identify potentially influential factors. In addition, molybdenum (Mo) and strontium (Sr) were analysed.

METHODS: Blood from 248 women aged 47-61 was analysed by high resolution inductively coupled plasma mass spectrometry under strict quality control.

RESULTS: The medians were: B-Pt 0.8 (range <0.6-5.2), B-Pd <5 (<5-9.3), B-Rh <0.4 (<0.4-3.6)ng/L and B-Mo 2.0 (0.2-16) and B-Sr 16.6 (3.5-49) μg/L. Two women with highly elevated B-Pt (242 and 60ng/L), previously cancer treated with cis-platinum, were not included in the data analysis. All elements varied geographically (2-3 times) (B-Pd P=0.05; all other elements P<0.001); variations within each area were generally 5-10 times. Traffic was not associated with increased concentrations.

CONCLUSIONS: General population blood concentrations of Pt, Pd and Rh are within or below the single digit ng/L range, much lower than in most previous reports. This is probably due to improved analytical performance, allowing for more reliable information at ultra-trace levels. In general, Mo and Sr agreed with previously reported concentrations. All elements showed geographical and inter-individual variations, but no convincing relationships with self-reported traffic intensity were found. Pt from the antineoplastic drug cis-platinum is retained in the body for years.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Biomarkers, Biomonitoring, Catalytic converters, Cis-platinum, High-resolution ICP-MS, Human, Metals, Traffic, Women
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-141952 (URN)10.1016/j.ijheh.2017.10.017 (DOI)000429397300008 ()29126886 (PubMedID)
Available from: 2017-11-16 Created: 2017-11-16 Last updated: 2018-06-09Bibliographically approved
Forsberg, B., Wahlgren, C., Lundström, N.-G. & Jonsson, L. (2014). Eldningsvanor inom några studieområden i Västerbotten.
Open this publication in new window or tab >>Eldningsvanor inom några studieområden i Västerbotten
2014 (Swedish)Report (Other academic)
Abstract [sv]

I syfte att få bättre underlag om vedeldningens omfattning och emissioner har en eldningsvaneundersökning genomförts i fyra områden inom Västerbotten. Undersökningen baseras på en besöksintervju genomförd av två personer vilka följt ett formulär med frågor och standardiserat sina klassificeringar av de intervjuades svar av mer öppen karaktär. Intervjuerna har genomförts i fyra områden med bebyggelse av olika ålder: Vännäs (kommuncentra), Vännäsby, Sävar och Tavleliden/Tomtebo (villaförort i Umeå). På dessa platser har partikelmätningar i en punkt genomförts inom ramen för ett annat projekt, och kortvariga sotmätningar genomförts på fler platser. Hushåll till intervjuerna utvaldes utifrån att de enligt sotarregistret har någon form av ved- , flis- eller pelletseldning. Totalt intervjuades 176 hushåll, endast ett två ytterligare var tillfrågade och avböjde. Studien visar anläggningarnas användningsgrad, bl.a. bränsleförbrukning per år, vilket kan användas för att beräkna utsläppsmängder. För pannor fanns dock inget samband mellan hög sotnings-frekvens enligt sotarregistren och hög vedförbrukning per år enligt intervjuerna. De som har fjärrvärme som huvudsakligt uppvärmningssätt använder sin kamin/lokaleldstad mindre än den som i huvudsak värmer bostaden med el. Utsläpps- och haltberäkningar kan ta hänsyn till denna kunskap.

Publisher
p. 15
Series
Yrkes- och miljömedicin i Umeå rapporterar, ISSN 1654-7314 ; 2014:5
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-102916 (URN)
Available from: 2015-05-11 Created: 2015-05-11 Last updated: 2018-06-07Bibliographically approved
Pawlas, N., Strömberg, U., Carlberg, B., Cerna, M., Harari, F., Harari, R., . . . Bergdahl, I. A. (2013). Cadmium, mercury and lead in blood of urban women in Croatia, the Czech Republic, Poland, Slovakia, Slovenia, Sweden, China, Ecuador and Morocco. International Journal of Occupational Medicine and Environmental Health, 26(1), 58-72
Open this publication in new window or tab >>Cadmium, mercury and lead in blood of urban women in Croatia, the Czech Republic, Poland, Slovakia, Slovenia, Sweden, China, Ecuador and Morocco
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2013 (English)In: International Journal of Occupational Medicine and Environmental Health, ISSN 1232-1087, E-ISSN 1896-494X, Vol. 26, no 1, p. 58-72Article in journal (Refereed) Published
Abstract [en]

The aim of the study was to make an international comparison of blood levels of cadmium (B-Cd), lead (B-Pb) and mercury (B-Hg) of women in seven European, and three non-European cities, and to identify determinants. About 50 women (age: 46-62) from each city were recruited (totally 480) in 2006-2009. Interview and questionnaire data were obtained. Blood samples were analysed in one laboratory to avoid interlaboratory variation. Between the European cities, the B-Pb and B-Cd results vary little (range of geometric means: 13.5-27.0 mu g/l and 0.25-0.65 mu g/l, respectively); the variation of B-Hg was larger (0.40-1.38 mu g/l). Between the non-European cities the results for B-Pb, B-Cd and B-Hg were 19.2-68.0, 0.39-0.99 and 1.01-2.73 mu g/l, respectively. Smoking was a statistically significant determinant for B-Cd, while fish and shellfish intakes contributed to B-Hg and B-Pb, amalgam fillings also contributed to B-Hg. The present results confirm the previous results from children; the exposure to lead and cadmium varies only little between different European cities suggesting that other factors than the living area are more important. The study also confirms the previous findings of higher cadmium and lead levels in some non-European cities. The geographical variation for mercury is significant.

Keywords
Cadmium, Mercury, Lead, Blood, Urban Women, European cities, Non-European Cities
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-71115 (URN)10.2478/S13382-013-0071-9 (DOI)000317428800006 ()
Available from: 2013-05-21 Created: 2013-05-20 Last updated: 2018-06-08Bibliographically approved
Hruba, F., Stromberg, U., Cerna, M., Chen, C., Harari, F., Harari, R., . . . Bergdahl, I. A. (2012). Blood cadmium, mercury, and lead in children: An international comparison of cities in six European countries, and China, Ecuador, and Morocco. Environment International, 41, 29-34
Open this publication in new window or tab >>Blood cadmium, mercury, and lead in children: An international comparison of cities in six European countries, and China, Ecuador, and Morocco
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2012 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 41, p. 29-34Article in journal (Refereed) Published
Abstract [en]

Children's blood-lead concentration (B-Pb) is well studied, but little is known about cadmium (B-Cd) and mercury (B-Hg), in particular for central Europe. Such information is necessary for risk assessment and management. Therefore, we here describe and compare B-Pb, B-Cd and B-Hg in children in six European, and three non-European cities, and identify determinants of these exposures. About 50 school children (7-14 years) from each city were recruited (totally 433) in 2007-2008. Interview and questionnaire data were obtained. A blood sample was analyzed: only two laboratories with strict quality control were used. The European cities showed only minor differences for B-Cd (geometric means 0.11-0.17 mu g/L) and B-Pb (14-20 mu g/L), but larger for B-Hg (0.12-0.94 mu g/L). Corresponding means for the non-European countries were 0.21-0.26, 32-71, and 0.3-3.2 mu g/L, respectively. For B-Cd in European samples, traffic intensity close to home was a statistically significant determinant, for B-Hg fish consumption and amalgam fillings, and for B-Pb sex (boys higher). This study shows that European city children's B-Cd and B-Pb vary only little between countries; B-Hg differs considerably, due to varying tooth restoration practices and fish intake. Traffic intensity seemed to be a determinant for B-Cd. The metal concentrations were low from a risk perspective but the chosen non-European cities showed higher concentrations than the cities in Europe. (C) 2011 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
Oxford: Elsevier, 2012
Keywords
Cadmium, Mercury, Lead, Children, Exposure, Biomonitoring
National Category
Environmental Sciences Ecology
Identifiers
urn:nbn:se:umu:diva-53922 (URN)10.1016/j.envint.2011.12.001 (DOI)000301684700004 ()
Available from: 2012-04-12 Created: 2012-04-10 Last updated: 2018-06-08Bibliographically approved
Nordberg, G. F., Lundström, N.-G., Forsberg, B., Hagenbjörk-Gustafsson, A., Lagerkvist, B.-S. J., Nilsson, J., . . . Eriksson, K. (2012). Lung function in volunteers before and after exposure to trichloramine in indoor pool environments and asthma in a cohort of pool workers. BMJ Open, 2(5), e000973
Open this publication in new window or tab >>Lung function in volunteers before and after exposure to trichloramine in indoor pool environments and asthma in a cohort of pool workers
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2012 (English)In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 2, no 5, p. e000973-Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Exposure to trichloramine (NCl(3)) in indoor swimming-pool environments is known to cause mucous membrane irritation, but if it gives rise to changes in lung function or asthma in adults is not known. (1) We determined lung function in volunteers before and after exposure to indoor pool environments. (2) We studied the occurrence of respiratory symptoms and asthma in a cohort of pool workers.

DESIGN/METHODS/PARTICIPANTS: (1) We studied two groups of volunteers, 37 previously non-exposed healthy persons and 14 pool workers, who performed exercise for 2 h in an indoor pool environment. NCl(3) in air was measured during pool exposures and in 10 other pool environments. Filtered air exposures were used as controls. Lung function and biomarkers of pulmonary epithelial integrity were measured before and after exposure. (2) We mailed a questionnaire to 1741 persons who indicated in the Swedish census 1990 that they worked at indoor swimming-pools.

RESULTS: (1) In previously non-exposed volunteers, statistically significant decreases in FEV(1) (forced expiratory volume) and FEV(%) (p=0.01 and 0.05, respectively) were found after exposure to pool air (0.23 mg/m(3) of NCl(3)). In pool workers, a statistically significant decrease in FEV(%) (p=0.003) was seen (but no significant change of FEV(1))(.) In the 10 other pool environments the median NCl(3) concentration was 0.18 mg/m(3). (2) Our nested case/control study in pool workers found an OR for asthma of 2.31 (95% CI 0.79 to 6.74) among those with the highest exposure. Exposure-related acute mucous membrane and respiratory symptoms were also found.

CONCLUSIONS: This is the first study in adults showing statistically significant decreases in lung function after exposure to NCl(3). An increased OR for asthma among highly exposed pool workers did not reach statistical significance, but the combined evidence supports the notion that current workroom exposures may contribute to asthma development. Further research on sensitive groups is warranted.

Place, publisher, year, edition, pages
BMJ Publishing Group, 2012
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-60838 (URN)10.1136/bmjopen-2012-000973 (DOI)23048058 (PubMedID)
Available from: 2012-10-31 Created: 2012-10-31 Last updated: 2018-06-08Bibliographically approved
Nordberg, G. & Lundström, N.-G. (2009). Hälsoeffekter av svaveldioxid: en litteraturstudie med betoning på de senaste årens publikationer. Umeå: Umeå universitet
Open this publication in new window or tab >>Hälsoeffekter av svaveldioxid: en litteraturstudie med betoning på de senaste årens publikationer
2009 (Swedish)Report (Other academic)
Abstract [sv]

Föreliggande rapport sammanfattar WHO:s senaste riktlinjer (WHO 2006) för luftkvalitet.Vidare redovisas en litteraturstudie rörande publikationer under de senaste åren angåendeexponering för SO2 och olika hälsoeffekter särskilt astma.

Bakgrunden till rapporten är det beslut angående Boliden AB´s verksamhet vidRönnskärsverken som träffades i Koncessionsnämnden 1998 06 16. I det kontrollprogramsom föreskrevs av Koncessionsnämnden skall ingå undersökningar hur korttidsvärden avsvaveldioxid varierar samt en karaktärisering av stoftutsläpp från verksamheten.

Utförda mätningar av SO2 under slutet av 1990-talet och början av 2000-talet innebär intenågot överskridande av gällande miljökvalitetsnorm. Eftersom denna norm bygger på tidigarepublicerad vetenskaplig litteratur är det angeläget att undersöka om nyare studier geranledning till större restriktivitet angående utsläpp av SO2.

WHO har uppdaterat sina riktlinjer för luftkvalitet (WHO 2006). Enligt de nya riktlinjernarekommenderas gräns för luftföroreningar (SO2) till 20 μg/m3 som 24 timmars medelvärdeoch 500 μg/m3 som tio minuters medelvärde.

Det är väl känt sedan tidigare att det finns ett samband mellan astmasymtom och exponeringför SO2 i luftföroreningar. Det har dock rått oklarhet om SO2 kan förorsaka astma eller om detär så att astmaanfall utlöses av förhöjda SO2 nivåer i luften hos personer som fått astma avandra anledningar.

En rad epidemiologiska studier, som delvis omnämns i föreliggande rapport, har visat påsamband mellan korttidshalter av SO2 och andra luftföroreningar och sjukhusinläggningar.

Den genomförda litteraturgenomgången visar att ett avsevärt antal studier finns publiceradeunder de senaste åren angående luftföroreningar, särskilt SO2 och astma. Det framgår i mångaav dessa studier att en ökning av astmasymtom har relaterats till ökande halter avluftföroreningar i städer. Vilken roll olika luftföroreningskomponenter spelar för uppkomstenav symtom framgår dock inte klart i de publicerade studierna.

WHO 2006 rekommenderade en riktlinje på 20 μg/m3 som dygnsmedelvärde för SO2 och destudier som publicerats 2006-2009 ger ytterligare stöd för denna uppfattning.

Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2009. p. 9
Series
Yrkes- och miljömedicin i Umeå rapporterar, ISSN 1654-7314 ; 2009:2
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-102663 (URN)
Available from: 2015-04-29 Created: 2015-04-29 Last updated: 2018-06-07Bibliographically approved
Lundström, N.-G., Englyst, V., Gerhardsson, L., Jin, T. & Nordberg, G. (2006). Lung cancer development in primary smelter workers: a nested case-referent study.. Journal of Occupational and Environmental Medicine, 48(4), 376-380
Open this publication in new window or tab >>Lung cancer development in primary smelter workers: a nested case-referent study.
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2006 (English)In: Journal of Occupational and Environmental Medicine, ISSN 1076-2752, E-ISSN 1536-5948, Vol. 48, no 4, p. 376-380Article in journal (Refereed) Published
Keywords
Arsenic Poisoning/*epidemiology, Case-Control Studies, Causality, Cohort Studies, Comorbidity, Follow-Up Studies, Humans, Inhalation Exposure/analysis/statistics & numerical data, Lead Poisoning/blood/*epidemiology, Logistic Models, Lung Neoplasms/*epidemiology, Male, Metallurgy/*statistics & numerical data, Models; Statistical, Occupational Diseases/blood/*epidemiology, Occupational Exposure/analysis/statistics & numerical data, Smoking/epidemiology, Survival Analysis, Sweden/epidemiology
Identifiers
urn:nbn:se:umu:diva-5906 (URN)10.1097/01.jom.0000201556.95982.95 (DOI)16607191 (PubMedID)
Available from: 2007-12-07 Created: 2007-12-07 Last updated: 2018-06-09Bibliographically approved
Gerhardsson, L., Akantis, A., Lundström, N.-G., Nordberg, G. F., Schütz, A. & Skerfving, S. (2005). Lead concentrations in cortical and trabecular bones in deceased smelter workers.. J Trace Elem Med Biol, 19(2-3), 209-15
Open this publication in new window or tab >>Lead concentrations in cortical and trabecular bones in deceased smelter workers.
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2005 (English)In: J Trace Elem Med Biol, ISSN 0946-672X, Vol. 19, no 2-3, p. 209-15Article in journal (Refereed) Published
Keywords
Age Factors, Aged, Bone and Bones/*metabolism, Calcium/analysis, Case-Control Studies, Humans, Lead/*analysis/blood, Male, Metallurgy, Middle Aged, Models; Statistical, Occupational Exposure, Spectrophotometry; Atomic, Spine/metabolism, Sternum/metabolism, Time Factors
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-18079 (URN)16325538 (PubMedID)
Available from: 2007-11-27 Created: 2007-11-27 Last updated: 2018-06-09Bibliographically approved
Jin, T., Wu, X., Tang, Y., Nordberg, M., Bernard, A., Ye, T., . . . Nordberg, G. F. (2004). Environmental epidemiological study and estimation of benchmark dose for renal dysfunction in a cadmium-polluted area in China.. Biometals, 17(5), 525-30
Open this publication in new window or tab >>Environmental epidemiological study and estimation of benchmark dose for renal dysfunction in a cadmium-polluted area in China.
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2004 (English)In: Biometals, ISSN 0966-0844, Vol. 17, no 5, p. 525-30Article in journal (Refereed) Published
Keywords
Acetylglucosaminidase/urine, Albuminuria/urine, Cadmium/toxicity/*urine, Cadmium Poisoning/*complications, China/epidemiology, Confidence Intervals, Environmental Exposure/adverse effects, Female, Humans, Isoenzymes/urine, Kidney Failure/chemically induced/*epidemiology, Kidney Glomerulus/drug effects, Kidney Tubules/drug effects, Male, Prevalence, Retinol-Binding Proteins/urine, Risk, beta 2-Microglobulin/urine
Identifiers
urn:nbn:se:umu:diva-18021 (URN)15688857 (PubMedID)
Available from: 2007-11-26 Created: 2007-11-26 Last updated: 2018-06-09Bibliographically approved
Lagerkvist, B. J. & Lundström, N.-G. (2004). Lead- and cadmium levels in children living close to a copper and lead smelter in Sweden. Biometals, 17(5), 593-594
Open this publication in new window or tab >>Lead- and cadmium levels in children living close to a copper and lead smelter in Sweden
2004 (English)In: Biometals, ISSN 0966-0844, E-ISSN 1572-8773, Vol. 17, no 5, p. 593-594Article in journal (Other academic) Published
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
urn:nbn:se:umu:diva-20784 (URN)10.1023/B:BIOM.0000045836.08562.dd (DOI)000224701600024 ()
Available from: 2009-03-25 Created: 2009-03-25 Last updated: 2018-06-09Bibliographically approved
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