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Eriksson, Jan
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Publications (10 of 32) Show all publications
Sun, C., Sedimbi, S. K., Ashok, A. K. & Sanjeevi, C. B. (2012). CRYAB-650 C>G (rs2234702) affects susceptibility to type 1 diabetes and IAA-positivity in Swedish population. Human Immunology, 73(7), 759-766
Open this publication in new window or tab >>CRYAB-650 C>G (rs2234702) affects susceptibility to type 1 diabetes and IAA-positivity in Swedish population
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2012 (English)In: Human Immunology, ISSN 0198-8859, E-ISSN 1879-1166, Vol. 73, no 7, p. 759-766Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. CRYAB gene, which encodes alpha B-crystallin (a member of small heat shock protein), was reported as a potential autoimmune target. In this study we investigated whether SNPs in the promoter region of CRYAB gene were also important in the etiology of Type 1 diabetes (T1D).

METHODS: Genotyping of SNPs in the promoter region of CRYAB gene was performed in a Swedish cohort containing 444 T1D patients and 350 healthy controls. Three SNPs were included in this study: CRYAB-652 A>G (rs762550), -650 C>G (rs2234702) and -249 C > G (rs14133). Two SNPs (CRYAB-652 and -650) were not included in previous genome wide association studies.

RESULTS: CRYAB-650 (rs2234702)*C allele was significantly more frequent in patients than in controls (OR = 1.48, Pc = 0.03). CRYAB-650*C allele was associated with IAA positivity (OR = 8.17, Pc < 0.0001) and IA-2A positivity (OR = 2.14, Pc = 0.005) in T1D patients. This association with IAA was amplified by high-risk HLA carrier state (OR = 10.6, P < 0.0001). No association was found between CRYAB-650 and other autoantibody positivity (GADA and ICA). CRYAB haplotypes were also associated with IAA and IA-2A positivity (highest OR = 2.07 and 2.11, respectively), these associations remain in high HLA-risk T1D patients.

CONCLUSIONS: CRYAB-650 was associated with T1D in the Swedish cohort we studied. CRYAB-650*C allele might confers susceptibility to the development of T1D. CRYAB-650 was also associated with the development of IAA-positivity in T1D patients, especially in those carrying T1D high-risk HLA haplotypes.

Place, publisher, year, edition, pages
Elsevier, 2012
Keywords
Autoimmunity, CRYAB, Haplotype, Type 1 diabetes, Swedish
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:umu:diva-101468 (URN)10.1016/j.humimm.2012.04.004 (DOI)000305775800013 ()22537749 (PubMedID)
Available from: 2015-03-31 Created: 2015-03-31 Last updated: 2018-06-07Bibliographically approved
Norberg, M., Stenlund, H., Lindahl, B., Andersson, C., Weinehall, L., Hallmans, G. & Eriksson, J. (2007). Components of metabolic syndrome predicting diabetes: no role of inflammation or dyslipidemia.. Obesity (Silver Spring), 15(7), 1875-1885
Open this publication in new window or tab >>Components of metabolic syndrome predicting diabetes: no role of inflammation or dyslipidemia.
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2007 (English)In: Obesity (Silver Spring), ISSN 1930-7381, Vol. 15, no 7, p. 1875-1885Article in journal (Refereed) Published
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-16214 (URN)10.1038/oby.2007.222 (DOI)17636107 (PubMedID)
Available from: 2007-11-30 Created: 2007-11-30 Last updated: 2018-06-09Bibliographically approved
Lundgren, M., Svensson, M., Lindmark, S., Renström, F., Ruge, T. & Eriksson, J. (2007). Fat cell enlargement is an independent marker of insulin resistance and 'hyperleptinaemia'.. Diabetologia, 50(3), 625-33
Open this publication in new window or tab >>Fat cell enlargement is an independent marker of insulin resistance and 'hyperleptinaemia'.
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2007 (English)In: Diabetologia, ISSN 0012-186X, Vol. 50, no 3, p. 625-33Article in journal (Refereed) Published
Keywords
Adipose Tissue/*cytology/pathology, Blood Pressure, Cell Size, Diabetes Mellitus; Type 2/*pathology/physiopathology, Female, Humans, Insulin Resistance/*physiology, Leptin/*blood, Male, Middle Aged, Obesity/epidemiology, Omentum/cytology/pathology, Reference Values
Identifiers
urn:nbn:se:umu:diva-18151 (URN)doi:10.1007/s00125-006-0572-1< (DOI)17216279 (PubMedID)
Available from: 2007-12-05 Created: 2007-12-05 Last updated: 2018-06-09Bibliographically approved
Renström, F., Buren, J., Svensson, M. & Eriksson, J. (2007). Insulin resistance induced by high glucose and high insulin precedes insulin receptor substrate 1 protein depletion in human adipocytes.. Metabolism: Clinical and Experimental, 56(2), 190-198
Open this publication in new window or tab >>Insulin resistance induced by high glucose and high insulin precedes insulin receptor substrate 1 protein depletion in human adipocytes.
2007 (English)In: Metabolism: Clinical and Experimental, ISSN 0026-0495, E-ISSN 1532-8600, Vol. 56, no 2, p. 190-198Article in journal (Refereed) Published
Keywords
Adipocytes/drug effects/*metabolism, Adult, Aged, Blotting; Western, Cells; Cultured, Female, Glucose/metabolism/*pharmacology, Glucose Transporter Type 4/metabolism, Humans, Hypoglycemic Agents/*pharmacology, Indicators and Reagents, Insulin/*pharmacology, Insulin Resistance/*physiology, Intracellular Signaling Peptides and Proteins/metabolism, Male, Middle Aged, Phosphoproteins/*metabolism, Signal Transduction/drug effects
Identifiers
urn:nbn:se:umu:diva-18201 (URN)doi:10.1016/j.metabol.2006.09.012< (DOI)17224332 (PubMedID)
Available from: 2007-11-29 Created: 2007-11-29 Last updated: 2018-06-09Bibliographically approved
Norberg, M., Stenlund, H., Lindahl, B., Andersson, C., Eriksson, J. & Weinehall, L. (2007). Work stress and low emotional support is associated with increased risk of future type 2 diabetes in women. Diabetes Research and Clinical Practice, 76(3), 368-377
Open this publication in new window or tab >>Work stress and low emotional support is associated with increased risk of future type 2 diabetes in women
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2007 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 76, no 3, p. 368-377Article in journal (Refereed) Published
Abstract [en]

A case-referent study nested within a population-based health survey investigated the associations between psychosocial stress, such as work stress and low emotional support, and future development of type 2 diabetes among occupationally working middle-aged men and women. All participants in a health survey conducted during 1989-2000 (n=33,336) in Umeå in northern Sweden, were included. We identified 191 cases, who were not diabetic initially but were diagnosed with type 2 diabetes after 5.4+/-2.6 years. Two age- and sex-matched referents were selected for each case. Multivariate logistic regression analyses and interaction effects between variables were evaluated.

In women, passive or tense working situations were associated with future type 2 diabetes with odds ratios 3.6 (95% confidence interval 1.1-11.7) and 3.6 (1.0-13.3), respectively, and also low emotional support 3.0 (1.3-7.0). These associations were not seen in men. In women, they remained after adjustment for BMI, civil status and educational level, and there were also tendencies for interactions between work stress and low emotional support.

In conclusion, work stress and low emotional support may increase the risk of type 2 diabetes in women, but not in men. These findings contribute to our understanding of psychosocial stress as potential risk factors for type 2 diabetes in a Swedish population.

National Category
General Practice
Identifiers
urn:nbn:se:umu:diva-14584 (URN)10.1016/j.diabres.2006.09.002 (DOI)17034894 (PubMedID)
Available from: 2007-09-12 Created: 2007-09-12 Last updated: 2018-06-09Bibliographically approved
Norberg, M., Eriksson, J., Lindahl, B., Andersson, C., Rolandsson, O., Stenlund, H. & Weinehall, L. (2006). A combination of HbA1c, fasting glucose and BMI is effective in screening for individuals at risk of future type 2 diabetes: OGTT is not needed.. Journal of Internal Medicine, 260(3), 263-71
Open this publication in new window or tab >>A combination of HbA1c, fasting glucose and BMI is effective in screening for individuals at risk of future type 2 diabetes: OGTT is not needed.
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2006 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 260, no 3, p. 263-71Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To identify a screening model that predicts high risk of future type 2 diabetes and is useful in clinical practice. DESIGN AND METHODS: Incident case-referent study nested within a population-based health survey. We compared screening models with three risk criteria and calculated sensitivity, specificity, positive (PPV) and negative (NPV) predictive values and attributable proportion. We used fasting plasma glucose (FPG) alone or with an oral glucose tolerance test (OGTT), glycosylated haemoglobin A (HbA1c) (normal range 3.6-5.3%), body mass index (BMI), triglycerides and family history of diabetes (FHD). SETTING: Participants in a health survey at all primary care centres (n=33,336) and subjects with diagnosed type 2 diabetes in primary and hospital care (n=6088) in Umeå during 1989-2001. SUBJECTS: Each of the 164 subjects who developed clinically diagnosed type 2 diabetes (median time to diagnosis of 5.4 years) and 304 sex- and age-matched referents without diabetes diagnosis. RESULTS: Screening models with at least one criterion present had sensitivities of 0.90-0.96, specificities of 0.43-0.57 and PPVs of 8-9%. Combinations of the criteria, FPG>or=6.1 mmol L-1 (capillary plasma), HbA1c>or=4.7% and BMI>or=27 in men and BMI>or=30 in women, had sensitivities, specificities and PPVs of 0.66%, 0.93% and 32%, and 0.52%, 0.97% and 46% respectively. Using FHD as one of three risk criteria showed comparable results. Addition of triglycerides or OGTT did not improve the prediction. CONCLUSIONS: The combination of HbA1c, FPG and BMI are effective in screening for individuals at risk of future clinical diagnosis of type 2 diabetes. OGTT or FHD is not necessary.

Keywords
Adult, Biological Markers/blood, Blood Glucose/*analysis, Body Mass Index, Case-Control Studies, Diabetes Mellitus; Type 2/*blood/diagnosis, Fasting/blood, Female, Glucose Tolerance Test, Health Surveys, Hemoglobin A; Glycosylated/*analysis, Humans, Logistic Models, Male, Middle Aged, Risk Assessment/methods, Sensitivity and Specificity, Sweden, Unnecessary Procedures
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:umu:diva-14580 (URN)10.1111/j.1365-2796.2006.01689.x (DOI)16918824 (PubMedID)
Available from: 2008-06-25 Created: 2008-06-25 Last updated: 2018-06-09Bibliographically approved
Bakhtadze, E., Borg, H., Stenström, G., Fernlund, P., Arnqvist, H. J., Ekbom-Schnell, A., . . . Sundkvist, G. (2006). HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.. Diabetologia, 49(8), 1785-1794
Open this publication in new window or tab >>HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.
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2006 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 49, no 8, p. 1785-1794Article in journal (Refereed) Published
Keywords
Adolescent, Adult, Autoantibodies/*analysis, C-Peptide/blood, DNA Primers, Diabetes Mellitus/*epidemiology/*genetics/pathology, Female, Genotype, Glutamate Decarboxylase/analysis, HLA-DQ Antigens/*genetics, Humans, Insulin-Secreting Cells/*physiology, Isoenzymes/analysis, Male, Sweden/epidemiology
Identifiers
urn:nbn:se:umu:diva-14116 (URN)10.1007/s00125-006-0293-5 (DOI)16783473 (PubMedID)
Available from: 2007-08-28 Created: 2007-08-28 Last updated: 2018-06-09Bibliographically approved
Lindmark, S., Burén, J. & Eriksson, J. W. (2006). Insulin resistance, endocrine function and adipokines in type 2 diabetes patients at different glycaemic levels: potential impact for glucotoxicity in vivo. Clinical Endocrinology, 65(3), 301-309
Open this publication in new window or tab >>Insulin resistance, endocrine function and adipokines in type 2 diabetes patients at different glycaemic levels: potential impact for glucotoxicity in vivo
2006 (English)In: Clinical Endocrinology, ISSN 0300-0664, E-ISSN 1365-2265, Vol. 65, no 3, p. 301-309Article in journal (Refereed) Published
Abstract [en]

Objective To evaluate the interplay between hyperglycaemia, insulin resistance, hormones and adipokines in patients with type 2 diabetes mellitus (T2DM). Design and methods Ten patients with T2DM with good glycaemic control (G), 10 with poor control (P) and 10 nondiabetic control subjects (C) were matched for sex (M/F 6/4), age and body mass index. A hyperinsulinaemic, euglycaemic clamp was performed and cytokines and endocrine functions, including cortisol axis activity were assessed. Results Patients with diabetes were more insulin resistant than group C, and group P exhibited the highest degree of insulin resistance ( P = 0·01, P vs C). Tumour necrosis factor (TNF)-alpha levels were elevated in patients with diabetes ( P = 0·05) and group P had the highest levels of fasting serum cortisol ( P = 0·05), nonesterified fatty acids (NEFA; P = 0·06) and C-reactive protein (CRP; P = 0·01). Adiponectin levels were lower in the P group. In partial correlation analyses, significant associations were found: glycaemic level (HbA1c) with insulin resistance, TNF-alpha, CRP and basal and ACTH-stimulated cortisol levels, insulin resistance with plasma NEFA, TNF-alpha and stimulated cortisol levels. Conclusion Poor glycaemic control in patients with T2DM was associated with insulin resistance and with elevated TNF-alpha, CRP and basal as well as stimulated cortisol levels. Inflammatory mediators, e.g. TNF-alpha, may contribute to insulin resistance in hyperglycaemic patients with T2DM and this might be a partial explanation for glucotoxicity.

Keywords
adipose tissue/*metabolism, adrenocorticotropic hormone/diagnostic use, analysis of variance, blood glucose/analysis, c-reactive protein/analysis, case-control studies, dexamethasone/diagnostic use, diabetes mellitus; type 2/*metabolism, fatty acids, nonesterified/blood, glucocorticoids/diagnostic use, glucose clamp technique, humans, hydrocortisone/blood, insulin resistance, interleukin-6/*metabolism, linear models, stimulation, chemical, tumor necrosis factor-alpha/*metabolism
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-15370 (URN)10.1111/j.1365-2265.2006.02593.x (DOI)16918948 (PubMedID)
Available from: 2007-07-05 Created: 2007-07-05 Last updated: 2018-06-09Bibliographically approved
Svensson, M. & Eriksson, J. (2006). Insulin resistance in diabetic nephropathy--cause or consequence?. Diabetes Metab Res Rev, 22(5), 401-10
Open this publication in new window or tab >>Insulin resistance in diabetic nephropathy--cause or consequence?
2006 (English)In: Diabetes Metab Res Rev, ISSN 1520-7552, Vol. 22, no 5, p. 401-10Article in journal (Refereed) Published
Keywords
Albuminuria, Diabetic Nephropathies/etiology/*physiopathology, Humans, Insulin Resistance, Renal Insufficiency; Chronic/etiology/physiopathology, Risk Factors
Identifiers
urn:nbn:se:umu:diva-15395 (URN)doi:10.1002/dmrr.648 (DOI)16703644 (PubMedID)
Available from: 2007-07-05 Created: 2007-07-05 Last updated: 2018-06-09Bibliographically approved
Ruge, T., Sukonina, V., Myrnäs, T., Lundgren, M., Eriksson, J. & Olivecrona, G. (2006). Lipoprotein lipase activity/mass ratio is higher in omental than in subcutaneous adipose tissue.. European Journal of Clinical Investigation, 36(1), 16-21
Open this publication in new window or tab >>Lipoprotein lipase activity/mass ratio is higher in omental than in subcutaneous adipose tissue.
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2006 (English)In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 36, no 1, p. 16-21Article in journal (Refereed) Published
Keywords
Abdomen/surgery, Adipose Tissue/*enzymology, Anthropometry, Biopsy, Female, Gene Expression, Humans, Lipids/blood, Lipoprotein Lipase/biosynthesis/genetics/*metabolism, Male, Middle Aged, Omentum/*enzymology, RNA; Messenger/genetics, Subcutaneous Fat/enzymology
Identifiers
urn:nbn:se:umu:diva-15287 (URN)10.1111/j.1365-2362.2006.01584.x (DOI)16403005 (PubMedID)
Available from: 2008-01-11 Created: 2008-01-11 Last updated: 2018-06-09Bibliographically approved
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