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Thunberg, Johan
Publications (2 of 2) Show all publications
Törnell, S., Ekeus, C., Hultin, M., Håkansson, S., Thunberg, J. & Högberg, U. (2015). Low Apgar score, neonatal encephalopathy and epidural analgesia during labour: a Swedish registry-based study. Acta Anaesthesiologica Scandinavica, 59(4), 486-495
Open this publication in new window or tab >>Low Apgar score, neonatal encephalopathy and epidural analgesia during labour: a Swedish registry-based study
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2015 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 59, no 4, p. 486-495Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Maternal intrapartum fever (MF) is associated with neonatal sequelae, and women in labour who receive epidural analgesia (EA) are more likely to develop hyperthermia. The aims of this study were to investigate if EA and/or a diagnosis of MF were associated to adverse neonatal outcomes at a population level. METHODS: Population-based register study with data from the Swedish Birth Register and the Swedish National Patient Register, including all nulliparae (n = 294,329) with singleton pregnancies who gave birth at term in Sweden 1999-2008. Neonatal outcomes analysed were Apgar score (AS) < 7 at 5 min and ICD-10 diagnosis of neonatal encephalopathy (e.g. convulsions or neonatal cerebral ischaemia). Multivariate logistic regression was used to calculate adjusted odds ratios (AOR) with 95% confidence intervals (CI). RESULTS: EA was used in 44% of the deliveries. Low AS or encephalopathy was found in 1.26% and 0.39% of the children in the EA group compared with 0.80% and 0.29% in the control group. In multivariate analysis, EA was associated with increased risk with low AS, AOR 1.27 (95% CI 1.16-1.39), but not with diagnosis of encephalopathy, 1.11 (0.96-1.29). A diagnosis of MF was associated with increased risk for both low AS, 2.27 (1.71-3.02), and of neonatal encephalopathy, 1.97 (1.19-3.26). CONCLUSION: Diagnosis of MF was associated with low AS and neonatal encephalopathy, whereas EA was only associated with low AS and not with neonatal encephalopathy. The found associations might be a result of confounding by indication, which is difficult to assess in a registry-based population study.

National Category
Anesthesiology and Intensive Care Pediatrics
Identifiers
urn:nbn:se:umu:diva-100264 (URN)10.1111/aas.12477 (DOI)000351537900010 ()1399-6576 (Electronic) 0001-5172 (Linking) (ISBN)
Available from: 2015-02-27 Created: 2015-02-27 Last updated: 2018-06-07Bibliographically approved
Brorsson, C., Dahlqvist, P., Nilsson, L., Thunberg, J., Sylvan, A. & Naredi, S. (2014). Adrenal response after trauma is affected by time after trauma and sedative/analgesic drugs. Injury, 45(8), 1149-1155
Open this publication in new window or tab >>Adrenal response after trauma is affected by time after trauma and sedative/analgesic drugs
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2014 (English)In: Injury, ISSN 0020-1383, E-ISSN 1879-0267, Vol. 45, no 8, p. 1149-1155Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The adrenal response in critically ill patients, including trauma victims, has been debated over the last decade. The aim of this study was to assess the early adrenal response after trauma. METHODS: Prospective, observational study of 50 trauma patients admitted to a level-1-trauma centre. Serum and saliva cortisol were followed from the accident site up to five days after trauma. Corticosteroid binding globulin (CBG), dehydroepiandrosterone (DHEA) and sulphated dehydroepiandrosterone (DHEAS) were obtained twice during the first five days after trauma. The effect of time and associations between cortisol levels and; severity of trauma, infusion of sedative/analgesic drugs, cardiovascular dysfunction and other adrenocorticotropic hormone (ACTH) dependent hormones (DHEA/DHEAS) were studied. RESULTS: There was a significant decrease over time in serum cortisol both during the initial 24 h, and from the 2nd to the 5th morning after trauma. A significant decrease over time was also observed in calculated free cortisol, DHEA, and DHEAS. No significant association was found between an injury severity score >/= 16 (severe injury) and a low (< 200 nmol/L) serum cortisol at any time during the study period. The odds for a serum cortisol < 200 nmol/L was eight times higher in patients with continuous infusion of sedative/analgesic drugs compared to patients with no continuous infusion of sedative/analgesic drugs. CONCLUSION: Total serum cortisol, calculated free cortisol, DHEA and DHEAS decreased significantly over time after trauma. Continuous infusion of sedative/analgesic drugs was independently associated with serum cortisol < 200 nmol/L.

Place, publisher, year, edition, pages
Elsevier, 2014
Keywords
Multiple trauma, Adrenal insufficiency, Sedatives
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:umu:diva-91640 (URN)10.1016/j.injury.2014.02.001 (DOI)000340279500004 ()24975481 (PubMedID)1879-0267 (Electronic) 0020-1383 (Linking) (ISBN)
Available from: 2014-08-13 Created: 2014-08-13 Last updated: 2018-06-07Bibliographically approved
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