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Zhang, Jie-Xian
Publications (8 of 8) Show all publications
Isaksson, H., Landberg, R., Sundberg, B., Lundin, E., Hallmans, G., Zhang, J.-X., . . . Åman, P. (2013). High-fiber rye diet increases ileal excretion of energy and macronutrients compared with low-fiber wheat diet independent of meal frequency in ileostomy subjects. Food & Nutrition Research, 57, 18519
Open this publication in new window or tab >>High-fiber rye diet increases ileal excretion of energy and macronutrients compared with low-fiber wheat diet independent of meal frequency in ileostomy subjects
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2013 (English)In: Food & Nutrition Research, ISSN 1654-6628, E-ISSN 1654-661X, Vol. 57, p. 18519-Article in journal (Refereed) Published
Abstract [en]

Background: Whole-grain foods and cereal dietary fiber intake is associated with lower body weight. This may partly result from lower energy utilization of high-fiber diets. Objective: In the present study, the impact on ileal excretion of energy and macronutrients in response to a rye bread high-fiber diet compared to a refined wheat low-fiber diet was investigated. Furthermore, the effect of meal frequency on apparent absorption of nutrients was studied for the first time. Design: Ten participants that had undergone ileostomy consumed standardized iso-caloric diets, including low-fiber wheat bread (20 g dietary fiber per day) for 2 weeks followed by high-fiber rye bread (52 g dietary fiber per day) for 2 weeks. The diets were consumed in an ordinary (three meals per day) and a nibbling (seven meals per day) meal frequency in a cross-over design. Ileal effluents were collected during 24 h at the third day of each of the four dietary periods and analyzed for gross energy and nutrient contents. Results: The results showed that intake of rye bread high-fiber diet compared to the refined wheat low-fiber diet caused an increase in ileal excretion of energy and macronutrients. The effect was independent of meal frequency. This suggests that a high intake of rye may result in lower availability of macronutrients for small intestinal digestion and absorption. A regular intake of rye may therefore have implications for weight management.

Place, publisher, year, edition, pages
Järfälla: Co-Action Publishing, 2013
Keywords
rye bread, refined wheat, meal frequency, ileal excretion, ileostomy
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-84808 (URN)10.3402/fnr.v57i0.18519 (DOI)000328682200001 ()24358035 (PubMedID)
Available from: 2014-01-27 Created: 2014-01-20 Last updated: 2018-06-08Bibliographically approved
Moazzami, A. A., Zhang, J.-X., Kamal-Eldin, A., Aman, P., Hallmans, G., Johansson, J.-E. & Andersson, S.-O. (2011). Nuclear Magnetic Resonance-Based Metabolomics Enable Detection of the Effects of a Whole Grain Rye and Rye Bran Diet on the Metabolic Profile of Plasma in Prostate Cancer Patients. Journal of Nutrition, 141(12), 2126-2132
Open this publication in new window or tab >>Nuclear Magnetic Resonance-Based Metabolomics Enable Detection of the Effects of a Whole Grain Rye and Rye Bran Diet on the Metabolic Profile of Plasma in Prostate Cancer Patients
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2011 (English)In: Journal of Nutrition, ISSN 0022-3166, E-ISSN 1541-6100, Vol. 141, no 12, p. 2126-2132Article in journal (Refereed) Published
Abstract [en]

Prostate cancer (PC) is the most common cancer in the Western world and the second most important cancer causing male deaths, after lung cancer, in the United States and Britain. Lifestyle and dietary changes are recommended for men diagnosed with early-stage PC. It has been shown that a diet rich in whole grain (WG) rye reduces the progression of early-stage PC, but the underlying mechanism is not clear. This study sought to identify changes in the metabolic signature of plasma in patients with early-stage PC following intervention with a diet rich in WG rye and rye bran product (RP) compared with refined white wheat product (WP) as a tool for mechanistic investigation of the beneficial health effects of RP on PC progression. Seventeen PC patients received 485 g RP or WP in a randomized, controlled, crossover design during a period of 6 wk with a 2-wk washout period. At the end of each intervention period, plasma was collected after fasting and used for (1)H NMR-based metabolomics. Multilevel partial least squares discriminant analysis was used for paired comparisons of multivariate data. A metabolomics analysis of plasma showed an increase in 5 metabolites, including 3-hydroxybutyric acid, acetone, betaine, N,N-dimethylglycine, and dimethyl sulfone, after RP. To understand these metabolic changes, fasting plasma homocysteine, leptin, adiponectin, and glucagon were measured separately. The plasma homocysteine concentration was lower (P = 0.0171 and that of leptin tended to be lower (P = 0.07) after RP intake compared to WP intake. The increase in plasma 3-hydroxybutyric acid and acetone after RP suggests a shift in energy metabolism from anabolic to catabolic status, which could explain some of the beneficial health effects of WG rye, i.e., reduction in prostate-specific antigen and reduced 24-h insulin secretion. In addition, the increase in betaine and N,N-dimethylglycine and the decrease in homocysteine show a favorable shift in homocysteine metabolism after RP intake. J. Nutr. 141: 2126-2132, 2011.

Place, publisher, year, edition, pages
Bethesda: American Society for Nutrition, 2011
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:umu:diva-50861 (URN)10.3945/jn.111.148239 (DOI)000297387200005 ()
Available from: 2012-01-02 Created: 2011-12-29 Last updated: 2018-06-08Bibliographically approved
Landberg, R., Andersson, S.-O., Zhang, J.-X., Johansson, J.-E., Stenman, U.-H., Adlercreutz, H., . . . Hallmans, G. (2010). Rye whole grain and bran intake compared with refined wheat decreases urinary C-peptide, plasma insulin, and prostate specific antigen in men with prostate cancer. Journal of Nutrition, 140(12), 2180-2186
Open this publication in new window or tab >>Rye whole grain and bran intake compared with refined wheat decreases urinary C-peptide, plasma insulin, and prostate specific antigen in men with prostate cancer
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2010 (English)In: Journal of Nutrition, ISSN 0022-3166, E-ISSN 1541-6100, Vol. 140, no 12, p. 2180-2186Article in journal (Refereed) Published
Abstract [en]

Rye whole grain and bran intake has shown beneficial effects on prostate cancer progression in animal models, including lower tumor take rates, smaller tumor volumes, and reduced prostate specific antigen (PSA) concentrations. A human pilot study showed increased apoptosis after consumption of rye bran bread. In this study, we investigated the effect of high intake of rye whole grain and bran on prostate cancer progression as assessed by PSA concentration in men diagnosed with prostate cancer. Seventeen participants were provided with 485 g rye whole grain and bran products (RP) or refined wheat products with added cellulose (WP), corresponding to ~50% of daily energy intake, in a randomized controlled, crossover design. Blood samples were taken from fasting men before and after 2, 4, and 6 wk of treatment and 24-h urine samples were collected before the first intervention period and after treatment. Plasma total PSA concentrations were lower after treatment with RP compared with WP, with a mean treatment effect of -14% (P = 0.04). Additionally, fasting plasma insulin and 24-h urinary C-peptide excretion were lower after treatment with RP compared with WP (P < 0.01 and P = 0.01, respectively). Daily excretion of 5 lignans was higher after the RP treatment than after the WP treatment (P < 0.001). We conclude that whole grain and bran from rye resulted in significantly lower plasma PSA compared with a cellulose-supplemented refined wheat diet in patients with prostate cancer. The effect may be related to inhibition of prostate cancer progression caused by decreased exposure to insulin, as indicated by plasma insulin and urinary C-peptide excretion.

Identifiers
urn:nbn:se:umu:diva-38285 (URN)10.3945/jn.110.127688 (DOI)000285123300013 ()20980650 (PubMedID)
Available from: 2010-12-03 Created: 2010-12-03 Last updated: 2018-06-08Bibliographically approved
Witthöft, C. M., Arkbåge, K., Johansson, M., Lundin, E., Berglund, G., Zhang, J.-X., . . . Dainty, J. R. (2006). Folate absorption from folate-fortified and processed foods using a human ileostomy model.. British Journal of Nutrition, 95(1), 181-7
Open this publication in new window or tab >>Folate absorption from folate-fortified and processed foods using a human ileostomy model.
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2006 (English)In: British Journal of Nutrition, ISSN 0007-1145, Vol. 95, no 1, p. 181-7Article in journal (Refereed) Published
Keywords
Absorption, Aged, Area Under Curve, Bread, Dairy Products, Diet, Dietary Proteins/metabolism, Female, Folic Acid/blood/*pharmacokinetics/urine, Food Handling/*methods, Food; Fortified, Humans, Ileostomy, Male, Middle Aged, Models; Biological, Pteroylpolyglutamic Acids/metabolism, Tetrahydrofolates/administration & dosage/pharmacokinetics
Identifiers
urn:nbn:se:umu:diva-18043 (URN)16441932 (PubMedID)
Available from: 2007-11-26 Created: 2007-11-26 Last updated: 2018-06-09Bibliographically approved
Bylund, A., Saarinen, N., Zhang, J.-X., Bergh, A., Widmark, A., Johansson, A., . . . Mäkelä, S. (2005). Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivo.. Experimental biology and medicine (Maywood, N.J.: Print), 230(3), 217-223
Open this publication in new window or tab >>Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivo.
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2005 (English)In: Experimental biology and medicine (Maywood, N.J.: Print), ISSN 1535-3702, E-ISSN 1535-3699, Vol. 230, no 3, p. 217-223Article in journal (Refereed) Published
Abstract [en]

Clinical intervention studies and experimental studies with lignan-rich diets suggest that lignans may have inhibitory effects on prostate cancer, but no clinical or experimental studies with purified lignans have been published. The purpose of this study was to investigate the effect of a plant lignan 7-hydroxymatairesinol (HMR) on LNCaP human prostate cancer xenografts in athymic mice. Athymic nude male mice were injected subcutaneously with LNCaP cells. Starting 3 days after tumor cell injections, a control diet or a control diet supplemented with 0.15% or 0.30% of HMR was administered to mice and the tumor take rate and growth was observed for 9 weeks. HMR diet inhibited the growth of LNCaP tumors. Mice treated with HMR had smaller tumor volume, lower tumor take rate, increased proportion of nongrowing tumors, and higher tumor cell apoptotic index compared with controls. Furthermore, the cell proliferation index was reduced in mice receiving the 0.30% HMR diet compared with mice receiving the control diet. Our results suggest that dietary HMR started at the early phase of the tumor development inhibits the growth of the LNCaP human prostate cancer xenografts in athymic male mice.

Keywords
Phytoestrogens, 7-hydroxymatairesinol, diet, LNCaP human prostate adenocarcinoma, athymic nude mice
Identifiers
urn:nbn:se:umu:diva-14291 (URN)15734725 (PubMedID)
Available from: 2008-01-16 Created: 2008-01-16 Last updated: 2018-06-09Bibliographically approved
Wikström, P., Bylund, A., Zhang, J.-X., Hallmans, G., Stattin, P. & Bergh, A. (2005). Rye bran diet increases epithelial cell apoptosis and decreases epithelial cell volume in TRAMP (transgenic adenocarcinoma of the mouse prostate) tumors.. Nutrition Cancer, 53(1), 111-6
Open this publication in new window or tab >>Rye bran diet increases epithelial cell apoptosis and decreases epithelial cell volume in TRAMP (transgenic adenocarcinoma of the mouse prostate) tumors.
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2005 (English)In: Nutrition Cancer, ISSN 0163-5581, Vol. 53, no 1, p. 111-6Article in journal (Refereed) Published
Keywords
Adenocarcinoma/*diet therapy/pathology, Animals, Antineoplastic Agents; Phytogenic/*pharmacology, Apoptosis/*drug effects, Cell Division/drug effects, Epithelial Cells, Immunohistochemistry, Male, Mice, Mice; Inbred C57BL, Mice; Transgenic, Prostatic Neoplasms/*diet therapy/pathology, Random Allocation, Secale cereale
Identifiers
urn:nbn:se:umu:diva-14255 (URN)16351513 (PubMedID)
Available from: 2008-01-16 Created: 2008-01-16 Last updated: 2018-06-09Bibliographically approved
Lundin, E., Zhang, J.-X., Lairon, D., Tidehag, P., Aman, P., Adlercreutz, H. & Hallmans, G. (2004). Effects of meal frequency and high-fibre rye-bread diet on glucose and lipid metabolism and ileal excretion of energy and sterols in ileostomy subjects.. European Journal of Clinical Nutrition, 58(10), 1410-9
Open this publication in new window or tab >>Effects of meal frequency and high-fibre rye-bread diet on glucose and lipid metabolism and ileal excretion of energy and sterols in ileostomy subjects.
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2004 (English)In: European Journal of Clinical Nutrition, ISSN 0954-3007, Vol. 58, no 10, p. 1410-9Article in journal (Refereed) Published
Keywords
Adult, Aged, Bile Acids and Salts/metabolism, Blood Glucose/drug effects/*metabolism, Bread, C-Peptide/urine, Colitis; Ulcerative/surgery, Cross-Over Studies, Dietary Fiber/*administration & dosage/metabolism, Energy Metabolism/physiology, Feeding Behavior/*physiology, Female, Humans, Ileostomy, Ileum/*metabolism, Insulin/blood/secretion, Lipid Metabolism, Male, Middle Aged, Secale cereale, Sterols/metabolism
Identifiers
urn:nbn:se:umu:diva-17984 (URN)15100716 (PubMedID)
Available from: 2007-11-26 Created: 2007-11-26 Last updated: 2018-06-09Bibliographically approved
Bylund, A., Lundin, E., Zhang, J.-X., Nordin, A., Kaaks, R., Stenman, U.-H., . . . Stattin, P. (2003). Randomised controlled short-term intervention pilot study on rye bran bread in prostate cancer.. European Journal of Cancer Prevention, 12(5), 407-415
Open this publication in new window or tab >>Randomised controlled short-term intervention pilot study on rye bran bread in prostate cancer.
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2003 (English)In: European Journal of Cancer Prevention, ISSN 0959-8278, E-ISSN 1473-5709, Vol. 12, no 5, p. 407-415Article in journal (Refereed) Published
Keywords
Aged, Apoptosis, Bread, Cell Division, Dietary Fiber, Estrogens/pharmacokinetics, Gonadal Steroid Hormones/blood, Humans, Male, Middle Aged, Prostate-Specific Antigen/analysis, Prostatic Neoplasms/blood supply/*physiopathology/therapy, Secale cereale, Somatomedins/analysis, Weight Loss
Identifiers
urn:nbn:se:umu:diva-15175 (URN)14512806 (PubMedID)
Available from: 2007-11-23 Created: 2007-11-23 Last updated: 2018-06-09Bibliographically approved
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